While revascularization is acknowledged as a critical process in wound healing, the scenario becomes more complex when considering diabetic wounds. In such cases, oxidative stress introduces two primary challenges that impede the healing process: ensuring the directional movement of functional cells to the wound site and combating the heightened risk of infection. These challenges underscore the need for innovative therapeutic strategies that can effectively address these restrictions in the context of diabetic wound healing. Hydrogen sulfide (HS) acts as a signaling gas and shows significant therapeutic potential in biomedical research. In this study, we encapsulate Allicin, a natural HS donor, in selenium micelles that specifically respond to oxidative stress. To create the GMA (Allicin@Micelle-GelMA) Composite hydrogel system, we utilize Methacrylic anhydride gelatin (GelMA) hydrogel as a matrix and form it through in-situ light curing. This composite system effectively addresses the problem of healing deep, narrow, and lengthy wounds that pose a challenge, as well as preventing nonspecific sudden release of HS. Additionally, the composite hydrogel system promotes angiogenesis, anti-inflammatory, antibacterial, and antioxidant properties. It also facilitates the directional movement of stem cells and macrophages, as demonstrated through the chicken embryo chorioallantoic membrane vascular test and the establishment of a diabetes wound model that is difficult to heal. Consequently, we conclude that the GMA composite hydrogel has the potential to serve as a versatile skin wound dressing that can effectively respond to oxidative stress.
{"title":"Oxidative stress-responsive hydrogen sulfide-releasing composite hydrogel for refractory diabetic wounds repair","authors":"Jingyue Wang, Yilei Ding, Jianan Liu, Yian Chen, Yuanfeng Wang, Ansha Zhao","doi":"10.1016/j.apmt.2024.102387","DOIUrl":"https://doi.org/10.1016/j.apmt.2024.102387","url":null,"abstract":"While revascularization is acknowledged as a critical process in wound healing, the scenario becomes more complex when considering diabetic wounds. In such cases, oxidative stress introduces two primary challenges that impede the healing process: ensuring the directional movement of functional cells to the wound site and combating the heightened risk of infection. These challenges underscore the need for innovative therapeutic strategies that can effectively address these restrictions in the context of diabetic wound healing. Hydrogen sulfide (HS) acts as a signaling gas and shows significant therapeutic potential in biomedical research. In this study, we encapsulate Allicin, a natural HS donor, in selenium micelles that specifically respond to oxidative stress. To create the GMA (Allicin@Micelle-GelMA) Composite hydrogel system, we utilize Methacrylic anhydride gelatin (GelMA) hydrogel as a matrix and form it through in-situ light curing. This composite system effectively addresses the problem of healing deep, narrow, and lengthy wounds that pose a challenge, as well as preventing nonspecific sudden release of HS. Additionally, the composite hydrogel system promotes angiogenesis, anti-inflammatory, antibacterial, and antioxidant properties. It also facilitates the directional movement of stem cells and macrophages, as demonstrated through the chicken embryo chorioallantoic membrane vascular test and the establishment of a diabetes wound model that is difficult to heal. Consequently, we conclude that the GMA composite hydrogel has the potential to serve as a versatile skin wound dressing that can effectively respond to oxidative stress.","PeriodicalId":8066,"journal":{"name":"Applied Materials Today","volume":"2 1","pages":""},"PeriodicalIF":8.3,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142178317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-14DOI: 10.1016/j.apmt.2024.102389
G.G. Goviazin, D.A. Goldstein, B. Ratzker, O. Messer, M. Sokol, D. Rittel
This study reveals that MAX phase materials can exhibit extraordinary reactivity when subjected to impact loading. This previously unknown behavior was discovered and examined in a case study of TiSiC subjected to Split Hopkinson pressure bar (SHPB) testing. The employed methodology integrated SHPB coupled with thermal measurements and ex-situ spectroscopic analysis, yielding crucial quantitative insights into MAX phase reactivity and mechanical impact response. We observed a substantial release of high energy in the form of elevated temperatures upon impact and disintegration of the MAX phase. Surprisingly, it was found that oxidation, usually the prominent contributor to reactivity, only plays a secondary role. Instead, microstructural transformation emerges as the primary source of energy release. It is postulated that the transformative kinetic mechanism involves rapid kinking, delamination, and bond breakage within the bulk material. These findings shed light on the fundamental energetics of MAX phases and highlight their potential as versatile reactive structural materials.
本研究揭示了 MAX 相材料在受到冲击载荷时会表现出非凡的反应性。在对 TiSiC 进行分体式霍普金森压力棒（SHPB）测试的案例研究中，发现并检验了这一之前未知的行为。所采用的方法将 SHPB 与热测量和原位光谱分析结合在一起，对 MAX 相反应性和机械冲击响应产生了重要的定量洞察。我们观察到 MAX 相在受到冲击和解体时以升温的形式释放出大量高能量。令人惊讶的是，我们发现通常对反应性起主要作用的氧化作用只起次要作用。相反，微结构转变成为能量释放的主要来源。据推测，转化动力学机制涉及块体材料内部的快速扭结、分层和断键。这些发现揭示了 MAX 相的基本能量学，并凸显了它们作为多功能活性结构材料的潜力。
{"title":"MAX phases: Unexpected reactivity under impact","authors":"G.G. Goviazin, D.A. Goldstein, B. Ratzker, O. Messer, M. Sokol, D. Rittel","doi":"10.1016/j.apmt.2024.102389","DOIUrl":"https://doi.org/10.1016/j.apmt.2024.102389","url":null,"abstract":"This study reveals that MAX phase materials can exhibit extraordinary reactivity when subjected to impact loading. This previously unknown behavior was discovered and examined in a case study of TiSiC subjected to Split Hopkinson pressure bar (SHPB) testing. The employed methodology integrated SHPB coupled with thermal measurements and ex-situ spectroscopic analysis, yielding crucial quantitative insights into MAX phase reactivity and mechanical impact response. We observed a substantial release of high energy in the form of elevated temperatures upon impact and disintegration of the MAX phase. Surprisingly, it was found that oxidation, usually the prominent contributor to reactivity, only plays a secondary role. Instead, microstructural transformation emerges as the primary source of energy release. It is postulated that the transformative kinetic mechanism involves rapid kinking, delamination, and bond breakage within the bulk material. These findings shed light on the fundamental energetics of MAX phases and highlight their potential as versatile reactive structural materials.","PeriodicalId":8066,"journal":{"name":"Applied Materials Today","volume":"131 1","pages":""},"PeriodicalIF":8.3,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142178316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-13DOI: 10.1016/j.apmt.2024.102392
Junshan Hu, Bin Duan, Jiancheng Yao, Tian Luo, Yuxiang Wu, Fengyi Wang, Tong Liu, Changchun Ding, Qunchao Fan, Hao Fu
Reversible upconversion luminescence (RUCL) modification based on photochromism has received considerable interest due to its potential applications in optical storage and invisible optical anti-counterfeiting. Herein, white β-BaScAlO: Yb, Er (β-BSAO-YE) phosphor was irradiated with 254 nm light, which caused the phosphor to turn blue due to the increase of oxygen vacancy. The blue β-BSAO-YE phosphor returns to its original color upon stimulation with 808 nm laser light or 125 °C, exhibiting a double photo-induced reversible photochromic change. The green and red upconversion luminescence (UCL) of the β-BSAO-YE were reversibly modified according to their photochromic properties. The UCL modification changes the luminescence color of the pattern, indicating that β-BSAO-YE phosphor is an ideal compound anti-counterfeit agent. The light information recorded on the β-BSAO-YE binary photochromic dot matrix can be read under ultraviolet (UV) and near-infrared (NIR) excitation, demonstrating the potential application of β-BSAO-YE phosphors as optical data storage media. In addition, the cyclic experiment showed good photochromic and UCL modulation repeatability. The new luminescent β-BSAO-YE not only proposes a new way to exploring upconversion red light materials, but also provides new materials for optical storage, optical information and optical anti-counterfeiting.
{"title":"Multimodal anti-counterfeiting and optical storage application based on luminescence reversible modification and color change of photochromic phosphor","authors":"Junshan Hu, Bin Duan, Jiancheng Yao, Tian Luo, Yuxiang Wu, Fengyi Wang, Tong Liu, Changchun Ding, Qunchao Fan, Hao Fu","doi":"10.1016/j.apmt.2024.102392","DOIUrl":"https://doi.org/10.1016/j.apmt.2024.102392","url":null,"abstract":"Reversible upconversion luminescence (RUCL) modification based on photochromism has received considerable interest due to its potential applications in optical storage and invisible optical anti-counterfeiting. Herein, white β-BaScAlO: Yb, Er (β-BSAO-YE) phosphor was irradiated with 254 nm light, which caused the phosphor to turn blue due to the increase of oxygen vacancy. The blue β-BSAO-YE phosphor returns to its original color upon stimulation with 808 nm laser light or 125 °C, exhibiting a double photo-induced reversible photochromic change. The green and red upconversion luminescence (UCL) of the β-BSAO-YE were reversibly modified according to their photochromic properties. The UCL modification changes the luminescence color of the pattern, indicating that β-BSAO-YE phosphor is an ideal compound anti-counterfeit agent. The light information recorded on the β-BSAO-YE binary photochromic dot matrix can be read under ultraviolet (UV) and near-infrared (NIR) excitation, demonstrating the potential application of β-BSAO-YE phosphors as optical data storage media. In addition, the cyclic experiment showed good photochromic and UCL modulation repeatability. The new luminescent β-BSAO-YE not only proposes a new way to exploring upconversion red light materials, but also provides new materials for optical storage, optical information and optical anti-counterfeiting.","PeriodicalId":8066,"journal":{"name":"Applied Materials Today","volume":"13 1","pages":""},"PeriodicalIF":8.3,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142178318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-13DOI: 10.1016/j.apmt.2024.102365
Roberto Bernasconi, Anna Nova, Buse Aktas, Salvador Pané, Luca Magagnin
Microrobotic swarms, with their intrinsic ability to multiply the properties of a single device by hundreds or thousands of times, demonstrate great potential for advanced microsurgery, targeted drug delivery or manipulation at the microscale. This is especially true in the case of magnetically actuated swarms, which can be remotely manipulated with high precision also in-vivo. The manufacturing and the collective actuation of a large number of devices, however, is a challenging task and it requires the development of highly tailored, adaptable and low cost strategies. In the present work, we demonstrate that a combination of inkjet assisted lithography (IAL) and electroforming can be a high-throughput, scalable and low-cost fabrication method for the production of disk-shaped ferromagnetic micromotors. Thanks to the versatility of the hybrid manufacturing technique developed, the diameter and the thickness of the devices can be easily controlled and tailored according to the target application. In addition, the use of electroforming makes possible the manufacturing of soft or hard magnetic devices, whose magnetization direction can be programmed. In the specific case, Ni and CoNiP devices were produced, characterized and actuated in swarms composed of hundreds of individuals. According to their magnetic properties, the devices exhibited highly controllable actuation patterns with multiple degrees of freedom. In order to provide an applicative perspective, the ferromagnetic micromotors were coated with polypyrrole and employed for drug delivery, evidencing thus their capability to load and release the model molecule Rhodamine B.
微型机器人群具有将单个设备的性能提高数百或数千倍的内在能力，在先进的显微外科手术、靶向药物输送或微观操作方面具有巨大潜力。尤其是磁驱动蜂群，可以在体内进行高精度的远程操控。然而，制造和集体驱动大量设备是一项具有挑战性的任务，需要开发高度定制、适应性强和低成本的策略。在本研究中，我们证明了喷墨辅助光刻（IAL）和电铸相结合是一种高通量、可扩展和低成本的制造方法，可用于生产盘状铁磁微电机。由于所开发的混合制造技术具有多功能性，因此可以根据目标应用轻松控制和定制器件的直径和厚度。此外，利用电铸技术还可以制造磁化方向可编程的软磁或硬磁器件。在这个具体案例中，镍和钴镍珀器件被生产出来，并在由数百个个体组成的群中进行表征和驱动。根据其磁性能，这些装置表现出高度可控的多自由度致动模式。为了提供一个应用角度，铁磁微电机涂覆了聚吡咯，并被用于药物输送，从而证明了它们装载和释放模型分子罗丹明 B 的能力。
{"title":"Inkjet assisted electroforming and collective actuation of disk-shaped magnetic micromotors","authors":"Roberto Bernasconi, Anna Nova, Buse Aktas, Salvador Pané, Luca Magagnin","doi":"10.1016/j.apmt.2024.102365","DOIUrl":"https://doi.org/10.1016/j.apmt.2024.102365","url":null,"abstract":"Microrobotic swarms, with their intrinsic ability to multiply the properties of a single device by hundreds or thousands of times, demonstrate great potential for advanced microsurgery, targeted drug delivery or manipulation at the microscale. This is especially true in the case of magnetically actuated swarms, which can be remotely manipulated with high precision also in-vivo. The manufacturing and the collective actuation of a large number of devices, however, is a challenging task and it requires the development of highly tailored, adaptable and low cost strategies. In the present work, we demonstrate that a combination of inkjet assisted lithography (IAL) and electroforming can be a high-throughput, scalable and low-cost fabrication method for the production of disk-shaped ferromagnetic micromotors. Thanks to the versatility of the hybrid manufacturing technique developed, the diameter and the thickness of the devices can be easily controlled and tailored according to the target application. In addition, the use of electroforming makes possible the manufacturing of soft or hard magnetic devices, whose magnetization direction can be programmed. In the specific case, Ni and CoNiP devices were produced, characterized and actuated in swarms composed of hundreds of individuals. According to their magnetic properties, the devices exhibited highly controllable actuation patterns with multiple degrees of freedom. In order to provide an applicative perspective, the ferromagnetic micromotors were coated with polypyrrole and employed for drug delivery, evidencing thus their capability to load and release the model molecule Rhodamine B.","PeriodicalId":8066,"journal":{"name":"Applied Materials Today","volume":"19 1","pages":""},"PeriodicalIF":8.3,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142178319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
High-intensity electric pulse treatment (EPT) can induce electric wind effect in materials, which facilitates the grain rearrangement and reorientation in polycrystalline samples. For the first time, this study employed the EPT technique to construct texture in MgAgSb bulk compounds, and a highly conductive channel was produced to promote the charge carrier transport. This leads to a 53 % improvement in carrier mobility of the EPT sample (4#20) over the pristine one at room temperature. Additionally, EPT does not affect the carrier concentration of the material, making the EPT samples possess significantly improved electrical conductivities and untouched Seebeck coefficients. Consequently, a 36 % improvement in value is achieved for the EPT sample (4#20) at 723 K, compared to the pristine one. This work demonstrates that EPT technique is an effective approach for constructing textured MgSb-based materials, offering a valuable avenue for high thermoelectric performance in other potential materials manipulating properties-related texture.
{"title":"Electric wind induced texturing for enhanced thermoelectric performance of p-type Mg3Sb2-based materials","authors":"Qiang Zhang, Yingpeng Gao, Hongyao Xie, Peifeng Ren, Zhaohui Shan, Jianfeng Fan","doi":"10.1016/j.apmt.2024.102391","DOIUrl":"https://doi.org/10.1016/j.apmt.2024.102391","url":null,"abstract":"High-intensity electric pulse treatment (EPT) can induce electric wind effect in materials, which facilitates the grain rearrangement and reorientation in polycrystalline samples. For the first time, this study employed the EPT technique to construct texture in MgAgSb bulk compounds, and a highly conductive channel was produced to promote the charge carrier transport. This leads to a 53 % improvement in carrier mobility of the EPT sample (4#20) over the pristine one at room temperature. Additionally, EPT does not affect the carrier concentration of the material, making the EPT samples possess significantly improved electrical conductivities and untouched Seebeck coefficients. Consequently, a 36 % improvement in value is achieved for the EPT sample (4#20) at 723 K, compared to the pristine one. This work demonstrates that EPT technique is an effective approach for constructing textured MgSb-based materials, offering a valuable avenue for high thermoelectric performance in other potential materials manipulating properties-related texture.","PeriodicalId":8066,"journal":{"name":"Applied Materials Today","volume":"80 1","pages":""},"PeriodicalIF":8.3,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142178321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Neonicotinoids as one of the newest major class of insecticides is a kind of persistent pollutants. Herein, copper-substituted zinc ferrites (CuZnFeO) prepared in subcritical aqueous solution has a nanosize of ∼2 nm with high crystallinity and strong magnetic property. At low catalyst dosage of 0.05 g L, peroxymonosulfate (PMS) can be effectively converted into sulfate radicals in CuZnFeO/PMS system. Thiamethoxam (THIA) degradation rate is in the order of CuZnFeO > CuFeO > ZnFeO (124, 84, 21 × 10 min, respectively). At pH ∼7.0, THIA degradation efficiency can be over 99 % in 40 min. The radical species (, HO, SO and O) were demonstrated by EPR spectra using probe molecules. The majority effects in CuZnFeO/PMS system with kinetics modelling were comprehensively investigated as well. This work provides that multi-metal coupling, , Cu(Ⅰ)/Cu(Ⅱ) & Fe(Ⅱ)/Fe(Ⅲ), in spinel structure by polyhedral design is an effective strategy for enhancing the catalytic activity. The CuZnFeO/PMS system has promising for water treatment of neonicotinoid insecticide with ease of recycling catalysts by magnetic separation.
{"title":"ZnFe2O4 substituted with Cu atoms for ultra-efficient formation of sulfate radicals: Extremely low catalyst dosage for thiamethoxam degradation","authors":"Yuan Gao, Lian-Peng Li, Si-Yan Gong, Jia-Hui Huang, Shuo Xiang, Gan He, Qiong-Yu Wang, Mian Hu, Junliang Wang, Zhiyan Pan, Zhong-Ting Hu","doi":"10.1016/j.apmt.2024.102390","DOIUrl":"https://doi.org/10.1016/j.apmt.2024.102390","url":null,"abstract":"Neonicotinoids as one of the newest major class of insecticides is a kind of persistent pollutants. Herein, copper-substituted zinc ferrites (CuZnFeO) prepared in subcritical aqueous solution has a nanosize of ∼2 nm with high crystallinity and strong magnetic property. At low catalyst dosage of 0.05 g L, peroxymonosulfate (PMS) can be effectively converted into sulfate radicals in CuZnFeO/PMS system. Thiamethoxam (THIA) degradation rate is in the order of CuZnFeO > CuFeO > ZnFeO (124, 84, 21 × 10 min, respectively). At pH ∼7.0, THIA degradation efficiency can be over 99 % in 40 min. The radical species (, HO, SO and O) were demonstrated by EPR spectra using probe molecules. The majority effects in CuZnFeO/PMS system with kinetics modelling were comprehensively investigated as well. This work provides that multi-metal coupling, , Cu(Ⅰ)/Cu(Ⅱ) & Fe(Ⅱ)/Fe(Ⅲ), in spinel structure by polyhedral design is an effective strategy for enhancing the catalytic activity. The CuZnFeO/PMS system has promising for water treatment of neonicotinoid insecticide with ease of recycling catalysts by magnetic separation.","PeriodicalId":8066,"journal":{"name":"Applied Materials Today","volume":"10 1","pages":""},"PeriodicalIF":8.3,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142178322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The tumor therapeutic efficacy of cisplatin as a chemotherapy drug and nanomaterial as a chemodynamic inducer are inhibited by the high levels of glutathione (GSH) and hypoxia within the tumor microenvironment. Herein, an injectable nanocomposite hydrogel platform is designed via encapsulating calcined MgMnFe-layered double hydroxide (LDH250) nanosheets and cisplatin into gelatin/hyaluronic acid double-crosslinked hydrogel. As an inducer of Fenton/Fenton-like reactions, LDH250 nanosheets exhibit multiple redox cycling pairs (Mn/Mn/Mn, Fe/Fe) capable of generating abundant reactive oxygen species (ROS), which synergizes with cisplatin to kill tumor cells effectively. Apart from this, the converse reaction of Mn into Mn allows LDH250 to consume GSH and produce O, thereby avoiding the deactivation of ROS and cisplatin, as well as alleviating hypoxia. These characteristics of LDH250 boost the anti-tumor effect of cisplatin and can be enhanced by modulating the calcination temperature. Furthermore, the hydrogels can reduce the transportation distance of ROS in chemodynamic therapy (CDT) and regulate the release of cisplatin. Based on these tactics, the nanocomposite hydrogel platform exhibits effective antitumor efficacy and . This work provides a platform for enhancing the therapeutic efficiency of chemotherapy/CDT by simultaneously depleting GSH and alleviating hypoxia.
{"title":"Cisplatin and ionic redox pairs co-delivery gelatin/hyaluronic acid hydrogels with amplified chemotherapy/chemodynamic tumor therapy","authors":"Shuhan Chen, Ru Xu, Panpan Huo, Junyu Liu, Dongdong Zhang, Jiajun Qiu, Xuanyong Liu","doi":"10.1016/j.apmt.2024.102388","DOIUrl":"https://doi.org/10.1016/j.apmt.2024.102388","url":null,"abstract":"The tumor therapeutic efficacy of cisplatin as a chemotherapy drug and nanomaterial as a chemodynamic inducer are inhibited by the high levels of glutathione (GSH) and hypoxia within the tumor microenvironment. Herein, an injectable nanocomposite hydrogel platform is designed via encapsulating calcined MgMnFe-layered double hydroxide (LDH250) nanosheets and cisplatin into gelatin/hyaluronic acid double-crosslinked hydrogel. As an inducer of Fenton/Fenton-like reactions, LDH250 nanosheets exhibit multiple redox cycling pairs (Mn/Mn/Mn, Fe/Fe) capable of generating abundant reactive oxygen species (ROS), which synergizes with cisplatin to kill tumor cells effectively. Apart from this, the converse reaction of Mn into Mn allows LDH250 to consume GSH and produce O, thereby avoiding the deactivation of ROS and cisplatin, as well as alleviating hypoxia. These characteristics of LDH250 boost the anti-tumor effect of cisplatin and can be enhanced by modulating the calcination temperature. Furthermore, the hydrogels can reduce the transportation distance of ROS in chemodynamic therapy (CDT) and regulate the release of cisplatin. Based on these tactics, the nanocomposite hydrogel platform exhibits effective antitumor efficacy and . This work provides a platform for enhancing the therapeutic efficiency of chemotherapy/CDT by simultaneously depleting GSH and alleviating hypoxia.","PeriodicalId":8066,"journal":{"name":"Applied Materials Today","volume":"59 1","pages":""},"PeriodicalIF":8.3,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142178323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-12DOI: 10.1016/j.apmt.2024.102385
Gulshan Verma, Anisha Gokarna, Hind Kadiri, Gilles Lerondel, Ankur Gupta
The growth of zinc oxide nanowires (ZnO NWs) on metal-seeded substrates is crucial for photonics, electronics, and sensing applications. Traditionally, NWs are grown using seed sintering on rigid substrates at high-temperature. However, the rise of flexible electronics, which use substrates unable to withstand high temperatures, has shifted focus to metal-assisted synthesis methods that do not require high-temperature sintering. This method has gained increasing attention due to its compatibility with flexible substrates. This article focuses on understanding the underlying growth mechanisms and achieving controlled growth of ZnO NWs on metal seeded flexible substrates. Furthermore, a parametric analysis is carried out to elucidate the correlation among different growth conditions in the chemical bath deposition (CBD) technique. Through a meticulously planned experimental design, the study investigates the influence of different growth conditions on synthesis outcomes. This leads to the formulation of predictive models using advanced machine learning (ML) methods particularly, artificial neural network (ANN). Following validation and training, the ANN model exhibits a remarkable ability to predict synthesis outcomes, yielding R values of 0.92 for diameter and 0.96 for length of NWs. Notably, the highest aspect ratio (AR) of ∼24 is attained following the growth conditions: 25 mM precursor concentration, 60 min growth time, and a growth temperature of 95 °C. Additionally, this method of growing ZnO NWs on a metal-seeded substrate offers an alternative approach for fabricating nanodevices for various emerging applications.
在金属种子基底上生长氧化锌纳米线（ZnO NWs）对于光子学、电子学和传感应用至关重要。传统上，纳米线是在刚性基底上通过高温烧结种子生长出来的。然而，由于柔性电子产品的兴起，其使用的基底无法承受高温，因此人们开始关注无需高温烧结的金属辅助合成方法。这种方法因其与柔性基底的兼容性而受到越来越多的关注。本文的重点是了解潜在的生长机制，并在金属种子柔性衬底上实现氧化锌纳米线的可控生长。此外，本文还进行了参数分析，以阐明化学浴沉积（CBD）技术中不同生长条件之间的相关性。通过精心策划的实验设计，该研究调查了不同生长条件对合成结果的影响。由此，利用先进的机器学习（ML）方法，特别是人工神经网络（ANN），建立了预测模型。经过验证和训练后，人工神经网络模型在预测合成结果方面表现出了卓越的能力，NWs 直径的 R 值为 0.92，长度的 R 值为 0.96。值得注意的是，在以下生长条件下，可获得 24 ∼ 24 的最高长宽比 (AR)：前驱体浓度为 25 mM，生长时间为 60 分钟，生长温度为 95 °C。此外，这种在金属衬底上生长氧化锌纳米线的方法为制造各种新兴应用的纳米器件提供了另一种方法。
{"title":"Flexible ZnO nanowire platform by metal-seeded chemical bath deposition: Parametric analysis and predictive modeling","authors":"Gulshan Verma, Anisha Gokarna, Hind Kadiri, Gilles Lerondel, Ankur Gupta","doi":"10.1016/j.apmt.2024.102385","DOIUrl":"https://doi.org/10.1016/j.apmt.2024.102385","url":null,"abstract":"The growth of zinc oxide nanowires (ZnO NWs) on metal-seeded substrates is crucial for photonics, electronics, and sensing applications. Traditionally, NWs are grown using seed sintering on rigid substrates at high-temperature. However, the rise of flexible electronics, which use substrates unable to withstand high temperatures, has shifted focus to metal-assisted synthesis methods that do not require high-temperature sintering. This method has gained increasing attention due to its compatibility with flexible substrates. This article focuses on understanding the underlying growth mechanisms and achieving controlled growth of ZnO NWs on metal seeded flexible substrates. Furthermore, a parametric analysis is carried out to elucidate the correlation among different growth conditions in the chemical bath deposition (CBD) technique. Through a meticulously planned experimental design, the study investigates the influence of different growth conditions on synthesis outcomes. This leads to the formulation of predictive models using advanced machine learning (ML) methods particularly, artificial neural network (ANN). Following validation and training, the ANN model exhibits a remarkable ability to predict synthesis outcomes, yielding R values of 0.92 for diameter and 0.96 for length of NWs. Notably, the highest aspect ratio (AR) of ∼24 is attained following the growth conditions: 25 mM precursor concentration, 60 min growth time, and a growth temperature of 95 °C. Additionally, this method of growing ZnO NWs on a metal-seeded substrate offers an alternative approach for fabricating nanodevices for various emerging applications.","PeriodicalId":8066,"journal":{"name":"Applied Materials Today","volume":"14 1","pages":""},"PeriodicalIF":8.3,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142178324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-10DOI: 10.1016/j.apmt.2024.102372
Giulia Scalet
Research into programmable materials has attracted extraordinary interest since the nineties, when the term “programmable” was introduced for the first time. In its widest definition, the term is used to denote materials that are designed to be highly dynamic, either in shape and/or physical/functional properties, on-demand and in a precise, sequential predetermined way. Such unique feature allows them to adapt to various needs and offers new opportunities in several application fields, enabling them to overcome the limitations of traditional materials. The present paper aims to introduce readers to the world of programmable materials, enhance their interest, knowledge, and skills in the field, and provide useful insights and new ideas on how to approach their development and implementation. Accordingly, this paper offers an overview and discussion of current state-of-the-art and recent progress up to future perspectives. First, the historical evolution and definition of these materials as well as the types of programmable properties achievable are presented. Then, the different programming strategies that could be used to tune material properties are covered, with an emphasis on the constituent materials, applied stimuli, and geometrical arrangements. Finally, real-world applications, ongoing challenges, and future directions for this exciting class of materials are discussed.
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Pub Date : 2024-08-10DOI: 10.1016/j.apmt.2024.102362
Erick Gabriel Ribeiro dos Anjos, Fabio Roberto Passador, André Balogh de Carvalho, Mirabel Cerqueira Rezende, Uttandaraman Sundararaj, Luiz Antonio Pessan
This study explores the processing and performance of acrylonitrile butadiene styrene (ABS)-based carbon ternary hybrid nanocomposites, incorporating carbon nanotubes (CNT), graphene nanoplatelets (GNP), and carbon black (CB), for applications in electromagnetic compatibility (EMC). The effect of nanocomposite processing on electromagnetic properties was evaluated by varying the mixing protocol, either through direct extrusion with simultaneous addition of all constituents or by preparing a master batch followed by dilution. The impact of nanofiller morphology and processing techniques on the behavior of nanocomposites was systematically investigated. Filaments of these nanocomposites were Additive Manufactured via Material Extrusion, and the resulting parts were evaluated for EMI shielding effectiveness (SE) in the X-band frequency range. The study reveals that the morphology, influenced by the processing strategy, significantly impacts the EMI SE properties of the printed samples. Particularly, ternary hybrids 3/3/3 wt% (CNT/GNP/CB) nanocomposites demonstrate promising electrical (0.003 S/cm), electromagnetic (29 dB of total attenuation), and mechanical performance (elastic modulus of 3080 MPa), with a clear advantage observed in those processed via direct extrusion. These nanocomposites were validated as feedstock filaments for 3D printing, and the printed sample exceeds the injection molded behavior for the composition 3/3/3 wt% (CNT/GNP/CB), achieving 40 dB of total attenuation at 11.8 GHz. The findings contribute valuable knowledge into tailoring nanocomposite formulations for additive manufacturing applications in EMI shielding, providing a nuanced understanding of the interplay between processing strategies, nanocomposite morphology, and resulting material properties.
本研究探讨了丙烯腈-丁二烯-苯乙烯（ABS）基碳三元混合纳米复合材料的加工和性能，其中包含碳纳米管（CNT）、石墨烯纳米片（GNP）和炭黑（CB），可用于电磁兼容（EMC）领域。通过改变混合方案，或者直接挤出并同时添加所有成分，或者先制备一批母料再进行稀释，评估了纳米复合材料加工对电磁特性的影响。系统研究了纳米填料形态和加工技术对纳米复合材料行为的影响。通过材料挤压对这些纳米复合材料的丝进行了添加制造，并评估了所得部件在 X 波段频率范围内的 EMI 屏蔽效果 (SE)。研究表明，受加工策略影响的形态对打印样品的 EMI SE 特性有显著影响。特别是，3/3/3 wt%（CNT/GNP/CB）三元混合纳米复合材料表现出良好的电气性能（0.003 S/cm）、电磁性能（29 dB 的总衰减）和机械性能（3080 MPa 的弹性模量），通过直接挤压加工的纳米复合材料具有明显的优势。这些纳米复合材料经验证可作为三维打印的原料长丝，打印样品的性能超过了成分为 3/3/3 wt%（CNT/GNP/CB）的注塑成型样品，在 11.8 GHz 频率下实现了 40 dB 的总衰减。这些研究结果为定制用于 EMI 屏蔽增材制造应用的纳米复合材料配方提供了宝贵的知识，使人们对加工策略、纳米复合材料形态和由此产生的材料特性之间的相互作用有了细致入微的了解。
{"title":"Advanced ternary carbon-based hybrid nanocomposites for electromagnetic functional behavior in additive manufacturing","authors":"Erick Gabriel Ribeiro dos Anjos, Fabio Roberto Passador, André Balogh de Carvalho, Mirabel Cerqueira Rezende, Uttandaraman Sundararaj, Luiz Antonio Pessan","doi":"10.1016/j.apmt.2024.102362","DOIUrl":"https://doi.org/10.1016/j.apmt.2024.102362","url":null,"abstract":"This study explores the processing and performance of acrylonitrile butadiene styrene (ABS)-based carbon ternary hybrid nanocomposites, incorporating carbon nanotubes (CNT), graphene nanoplatelets (GNP), and carbon black (CB), for applications in electromagnetic compatibility (EMC). The effect of nanocomposite processing on electromagnetic properties was evaluated by varying the mixing protocol, either through direct extrusion with simultaneous addition of all constituents or by preparing a master batch followed by dilution. The impact of nanofiller morphology and processing techniques on the behavior of nanocomposites was systematically investigated. Filaments of these nanocomposites were Additive Manufactured via Material Extrusion, and the resulting parts were evaluated for EMI shielding effectiveness (SE) in the X-band frequency range. The study reveals that the morphology, influenced by the processing strategy, significantly impacts the EMI SE properties of the printed samples. Particularly, ternary hybrids 3/3/3 wt% (CNT/GNP/CB) nanocomposites demonstrate promising electrical (0.003 S/cm), electromagnetic (29 dB of total attenuation), and mechanical performance (elastic modulus of 3080 MPa), with a clear advantage observed in those processed via direct extrusion. These nanocomposites were validated as feedstock filaments for 3D printing, and the printed sample exceeds the injection molded behavior for the composition 3/3/3 wt% (CNT/GNP/CB), achieving 40 dB of total attenuation at 11.8 GHz. The findings contribute valuable knowledge into tailoring nanocomposite formulations for additive manufacturing applications in EMI shielding, providing a nuanced understanding of the interplay between processing strategies, nanocomposite morphology, and resulting material properties.","PeriodicalId":8066,"journal":{"name":"Applied Materials Today","volume":"133 1","pages":""},"PeriodicalIF":8.3,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142178396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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