Pub Date : 2021-01-01DOI: 10.36648/2386-5180.21.9.346
A. Malik, Fatima Hamid, Mohammed Sir Alkhatim Mohammed Ahmed Fateh Elrahman Abshr, Mazin Mustafa Alkhair Abozaid, Mohammed Fadelmoula Sabahelkhair Idris, M. Hamad, Omar Abdalla Osman Ahmed, Safa Abu Eella Merghani Mohammed, Salma Yaha Algack Alnasry, Yomo Dino Yor Lual
Background: Human Cytomegalovirus (HCMV) is a microbe capable to establish lifetime tenacious infections. Schizophrenia is a mental malady described by atypical social behavior and failure to comprehend what is actual. Objectives: To recognize the seroprevalence of cytomegalovirus between schizophrenic patients in Khartoum state. Methods: Hospital based, descriptive cross sectional study, eighty schizophrenic patients participated in the study. Results: The CMV seropositive detected in 31 patients with the percentage 38.75%. 18 of seropositive patients were males with the percentage 58.06%, while 13 of them were female with the percentage 41.9%. Conclusion: Our study revealed that Males are more affected with both schizophrenia and cytomegalovirus. Further studies are required with large sample size and other laboratory diagnostic methods to detect CMV such as Polymerase chain reaction technique.
{"title":"Seroprevalence of Cytomegalovirus among Schizophrenic Patients in Khartoum State","authors":"A. Malik, Fatima Hamid, Mohammed Sir Alkhatim Mohammed Ahmed Fateh Elrahman Abshr, Mazin Mustafa Alkhair Abozaid, Mohammed Fadelmoula Sabahelkhair Idris, M. Hamad, Omar Abdalla Osman Ahmed, Safa Abu Eella Merghani Mohammed, Salma Yaha Algack Alnasry, Yomo Dino Yor Lual","doi":"10.36648/2386-5180.21.9.346","DOIUrl":"https://doi.org/10.36648/2386-5180.21.9.346","url":null,"abstract":"Background: Human Cytomegalovirus (HCMV) is a microbe capable to establish lifetime tenacious infections. Schizophrenia is a mental malady described by atypical social behavior and failure to comprehend what is actual. Objectives: To recognize the seroprevalence of cytomegalovirus between schizophrenic patients in Khartoum state. Methods: Hospital based, descriptive cross sectional study, eighty schizophrenic patients participated in the study. Results: The CMV seropositive detected in 31 patients with the percentage 38.75%. 18 of seropositive patients were males with the percentage 58.06%, while 13 of them were female with the percentage 41.9%. Conclusion: Our study revealed that Males are more affected with both schizophrenia and cytomegalovirus. Further studies are required with large sample size and other laboratory diagnostic methods to detect CMV such as Polymerase chain reaction technique.","PeriodicalId":8195,"journal":{"name":"Annals of Clinical and Laboratory Research","volume":"66 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74073381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.36648/2386-5180.21.9.350
A. Bansal, J. Prasad, H. Garg
Background: Sickle-cell anaemia is an inherited disease in which genes for sickle-cell haemoglobin comes from both parents. Electrolytes such as sodium (Na+), potassium (K+), chloride (Cl-) are essential for the normal functioning of the cells and organs. The present study was carried out to evaluate and determine the relationship between electrolytes values in Sickle cell anaemia patients. Aim: To compare serum electrolytes levels between Sickle cell and control group. Materials and Methods: Meta-analysis was carried out on the findings of ten published studies that were related to serum electrolytes levels of sickle cell anaemia patients. The pooled mean for serum electrolytes was estimated by using a random-effects model. Results: Pooled mean for serum sodium was lower in sickle cell anaemia with p value 0.04. However, potassium levels were higher in patients than controls with p value 0.01. Conclusion: Pooled mean reported in this study can be useful in working out the management of sickle cell anaemia.
{"title":"Comparison of Serum Electrolytes between Sickle Cell and Control Group: A Meta-Analysis","authors":"A. Bansal, J. Prasad, H. Garg","doi":"10.36648/2386-5180.21.9.350","DOIUrl":"https://doi.org/10.36648/2386-5180.21.9.350","url":null,"abstract":"Background: Sickle-cell anaemia is an inherited disease in which genes for sickle-cell haemoglobin comes from both parents. Electrolytes such as sodium (Na+), potassium (K+), chloride (Cl-) are essential for the normal functioning of the cells and organs. The present study was carried out to evaluate and determine the relationship between electrolytes values in Sickle cell anaemia patients. Aim: To compare serum electrolytes levels between Sickle cell and control group. Materials and Methods: Meta-analysis was carried out on the findings of ten published studies that were related to serum electrolytes levels of sickle cell anaemia patients. The pooled mean for serum electrolytes was estimated by using a random-effects model. Results: Pooled mean for serum sodium was lower in sickle cell anaemia with p value 0.04. However, potassium levels were higher in patients than controls with p value 0.01. Conclusion: Pooled mean reported in this study can be useful in working out the management of sickle cell anaemia.","PeriodicalId":8195,"journal":{"name":"Annals of Clinical and Laboratory Research","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83301357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.36648/2386-5180.21.9.351
S. Kharb, S. Gaur, Aparna, Rajni
Background: Polycystic Ovary Syndrome (PCOS), common cause of ovarian dysfunction. Vitamin D plays a physiologic role in reproduction including ovarian follicular development and luteinisation and its role in PCOS is not very clear. Aim and Objective: To analyse the serum levels of vitamin D among patients with PCOS and healthy controls. Materials and Methods: This cross-sectional study recruited 120 participants with PCOS and 120 healthy controls. After assessing the socio-demographic characteristics of the patients and their control, blood samples were drawn to carry out routine biochemical investigations and serum vitamin D. Results: Mean serum vitamin D levels in study group were lower as compared to controls. Vitamin D deficiency was present in 95.8% of women in study group and 85% of women in control group. Conclusion: Finding of lower vitamin D levels in PCOS women lends support to possible role of vitamin D in pathogenesis of PCOS. Screening for vitamin D deficiency in women with PCOS may provide better insight of its role in PCOS.
{"title":"Role of Vitamin D in Polycystic Ovarian Syndrome Patients","authors":"S. Kharb, S. Gaur, Aparna, Rajni","doi":"10.36648/2386-5180.21.9.351","DOIUrl":"https://doi.org/10.36648/2386-5180.21.9.351","url":null,"abstract":"Background: Polycystic Ovary Syndrome (PCOS), common cause of ovarian dysfunction. Vitamin D plays a physiologic role in reproduction including ovarian follicular development and luteinisation and its role in PCOS is not very clear. Aim and Objective: To analyse the serum levels of vitamin D among patients with PCOS and healthy controls. Materials and Methods: This cross-sectional study recruited 120 participants with PCOS and 120 healthy controls. After assessing the socio-demographic characteristics of the patients and their control, blood samples were drawn to carry out routine biochemical investigations and serum vitamin D. Results: Mean serum vitamin D levels in study group were lower as compared to controls. Vitamin D deficiency was present in 95.8% of women in study group and 85% of women in control group. Conclusion: Finding of lower vitamin D levels in PCOS women lends support to possible role of vitamin D in pathogenesis of PCOS. Screening for vitamin D deficiency in women with PCOS may provide better insight of its role in PCOS.","PeriodicalId":8195,"journal":{"name":"Annals of Clinical and Laboratory Research","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87517839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.36648/2386-5180.21.9.370
P. Nitheash, Bastian T.S., M. B. Cyriac, M. Selvamani, P. Malini
Introduction: Oral Submucous Fibrosis (OSF) is a common oral health problem in the Indian subcontinent. It was first reported by Schwartz and defined by Pindborg. OSF is within a group of conditions that are classified under potentially malignant disorders of the oral cavity. Current evidence suggests that are coline in the areca nut is the key factor in initiating the disease process. Objective: The purpose of this study is to conduct the morphometric analysis of the epithelial and selected connective tissue changes related to capillaries and to determine mast cell density in different grades of OSF. Method: The study comprises 25 cases of OSF in varying grades (according to Pindborg and Sirsat classification) retrieved from the archives of department of oral pathology. The slides were prepared and stained in Hematoxylin and Eosin stain and 1% toluidine blue. All the slides are being studied under Trinocular research microscope Olympus BX-53 and further quantified in image capture software for morphometric analysis. Result: Morphometrical analysis of epithelial thickness and connective tissue changes highlightening the parameters of capillary density, luminal diameter and circumferences of the capillaries have shown that varying degree of alterations in different grades of OSF when the severity of the disease increases. This study also included the mast cell density analysis which have proven to undergo changes as the severity of the disease progress.
{"title":"Epithelial and Connective Tissue Changes in Oral Submucous Fibrosis ?? A Morphometric Analysis","authors":"P. Nitheash, Bastian T.S., M. B. Cyriac, M. Selvamani, P. Malini","doi":"10.36648/2386-5180.21.9.370","DOIUrl":"https://doi.org/10.36648/2386-5180.21.9.370","url":null,"abstract":"Introduction: Oral Submucous Fibrosis (OSF) is a common oral health problem in the Indian subcontinent. It was first reported by Schwartz and defined by Pindborg. OSF is within a group of conditions that are classified under potentially malignant disorders of the oral cavity. Current evidence suggests that are coline in the areca nut is the key factor in initiating the disease process. Objective: The purpose of this study is to conduct the morphometric analysis of the epithelial and selected connective tissue changes related to capillaries and to determine mast cell density in different grades of OSF. Method: The study comprises 25 cases of OSF in varying grades (according to Pindborg and Sirsat classification) retrieved from the archives of department of oral pathology. The slides were prepared and stained in Hematoxylin and Eosin stain and 1% toluidine blue. All the slides are being studied under Trinocular research microscope Olympus BX-53 and further quantified in image capture software for morphometric analysis. Result: Morphometrical analysis of epithelial thickness and connective tissue changes highlightening the parameters of capillary density, luminal diameter and circumferences of the capillaries have shown that varying degree of alterations in different grades of OSF when the severity of the disease increases. This study also included the mast cell density analysis which have proven to undergo changes as the severity of the disease progress.","PeriodicalId":8195,"journal":{"name":"Annals of Clinical and Laboratory Research","volume":"112 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85859877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.36648/2386-5180.21.9.349
Lakshmi Vasudha.Y
{"title":"Clinical and laboratory parameters related to lysis neonatal jaundice","authors":"Lakshmi Vasudha.Y","doi":"10.36648/2386-5180.21.9.349","DOIUrl":"https://doi.org/10.36648/2386-5180.21.9.349","url":null,"abstract":"","PeriodicalId":8195,"journal":{"name":"Annals of Clinical and Laboratory Research","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85961952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.36648/2386-5180.21.9.371
A. Eftekhari, Dariush Shanehb, Sirus Hoseinnejhad, Zaker Ceferov, Z. Asefy
Studies revealed that neuroinflammation is main factor in Alzheimer's disease pathogenesis (AD). Synaptic dysfunction and neuronal death are caused by neuroinflammation. Proinflammatory mediators over expression directed nerve cells to Aβ peptide synthesis, hyper phosphorylated tau protein and up regulated inflammatory metabolites and cytokines. These inflammatory factors interrupt blood-brain barrier integrity and provide Aβ42 oligomers fabrication. Retinoids and carotenoids are effective antioxidants and anti-inflammatory mediators having neuroprotective effects. They suppress cognitive performance imperfection via several mechanisms such as repression of Aβ peptide synthesis, oxidative stress, and pro-inflammatory mediator’s. Retinoids, have significant consequences on central nervous system (CNS) development. Through this review we consider retinoids biology, underlining on their neuroprotective mechanisms that will beneficial to clarify their effect in AD pathology. Consequently, Retinoids is considered as a potent approach for AD prevention.
{"title":"Retinoids as Potential Therapeutic Approach in Prevention of Alzheimer's Disease","authors":"A. Eftekhari, Dariush Shanehb, Sirus Hoseinnejhad, Zaker Ceferov, Z. Asefy","doi":"10.36648/2386-5180.21.9.371","DOIUrl":"https://doi.org/10.36648/2386-5180.21.9.371","url":null,"abstract":"Studies revealed that neuroinflammation is main factor in Alzheimer's disease pathogenesis (AD). Synaptic dysfunction and neuronal death are caused by neuroinflammation. Proinflammatory mediators over expression directed nerve cells to Aβ peptide synthesis, hyper phosphorylated tau protein and up regulated inflammatory metabolites and cytokines. These inflammatory factors interrupt blood-brain barrier integrity and provide Aβ42 oligomers fabrication. Retinoids and carotenoids are effective antioxidants and anti-inflammatory mediators having neuroprotective effects. They suppress cognitive performance imperfection via several mechanisms such as repression of Aβ peptide synthesis, oxidative stress, and pro-inflammatory mediator’s. Retinoids, have significant consequences on central nervous system (CNS) development. Through this review we consider retinoids biology, underlining on their neuroprotective mechanisms that will beneficial to clarify their effect in AD pathology. Consequently, Retinoids is considered as a potent approach for AD prevention.","PeriodicalId":8195,"journal":{"name":"Annals of Clinical and Laboratory Research","volume":"48 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81151511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.36648/2386-5180.21.9.366
M. Witman
{"title":"The Important Role of Sunscreens in Minimizing the Occurrence of Skin Cancers in Dermatology","authors":"M. Witman","doi":"10.36648/2386-5180.21.9.366","DOIUrl":"https://doi.org/10.36648/2386-5180.21.9.366","url":null,"abstract":"","PeriodicalId":8195,"journal":{"name":"Annals of Clinical and Laboratory Research","volume":"62 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86803006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.36648/2386-5180.21.9.360
N. T. Traykovich, D. Nikolova, A. Argirov
Buschke-Lowenstein Tumor (BLT) is a very rare sexually- transmitted disease associated with human papillomavirus type 6 and 11, but rare cases of oncogenic HPV types including HPV 16 and HPV 18 were also reported. BLT is located in the genital, anorectal and perianal regions. It is regarded as a type of verrucous carcinoma occurring on anogenital mucosal surfaces where it is locally invasive but displays a benign cytology. Buschke-Lowenstein tumor can be associated with a high rate of recurrence and a risk of malignant transformation to invasive SCC, especially in patients with oncogenic types of HPV. We report the case of a 59-year-old female patient who addressed our clinic for a large, exophytic, cauliflower-like tumor involving the vulva, perineum and perianal regions with 20 years duration. The first lesions had been appeared on vulva and after 3 years period they grown slowly and covered perineum and perianal area. They had cauliflower like surface, with different sizes. In some points erosions and yellowish secretion with odor are observed. Histologic examination of a biopsy specimen of large tumor presented nets of well- differentiated squamous cell carcinoma, as well as a marked mononuclear cell infiltrate and conspicuous koilocytosis. HPV DNA for 6 and 11 types was detected with PCR. The patient was sent to the gynecology surgery department for excision and remains under the supervision of the dermatology and oncology department for rapid treatment of relapses and early detection of malignant transformation.
{"title":"Gaint Condylomata Acuminate of Buschke-Lowenstein in Woman with HPV Infection: Clinical Presentation and Treatment","authors":"N. T. Traykovich, D. Nikolova, A. Argirov","doi":"10.36648/2386-5180.21.9.360","DOIUrl":"https://doi.org/10.36648/2386-5180.21.9.360","url":null,"abstract":"Buschke-Lowenstein Tumor (BLT) is a very rare sexually- transmitted disease associated with human papillomavirus type 6 and 11, but rare cases of oncogenic HPV types including HPV 16 and HPV 18 were also reported. BLT is located in the genital, anorectal and perianal regions. It is regarded as a type of verrucous carcinoma occurring on anogenital mucosal surfaces where it is locally invasive but displays a benign cytology. Buschke-Lowenstein tumor can be associated with a high rate of recurrence and a risk of malignant transformation to invasive SCC, especially in patients with oncogenic types of HPV. We report the case of a 59-year-old female patient who addressed our clinic for a large, exophytic, cauliflower-like tumor involving the vulva, perineum and perianal regions with 20 years duration. The first lesions had been appeared on vulva and after 3 years period they grown slowly and covered perineum and perianal area. They had cauliflower like surface, with different sizes. In some points erosions and yellowish secretion with odor are observed. Histologic examination of a biopsy specimen of large tumor presented nets of well- differentiated squamous cell carcinoma, as well as a marked mononuclear cell infiltrate and conspicuous koilocytosis. HPV DNA for 6 and 11 types was detected with PCR. The patient was sent to the gynecology surgery department for excision and remains under the supervision of the dermatology and oncology department for rapid treatment of relapses and early detection of malignant transformation.","PeriodicalId":8195,"journal":{"name":"Annals of Clinical and Laboratory Research","volume":"174 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75711580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.36648/2386-5180.21.9.355
Lakshmi Vasudha
Arterial high vital sign (AH) is taken into consideration as a public condition owing to its high prevalence and difficult management and it’s in addition depicted joined of the foremost very important risk factors for vas diseases. Thisstudy aimed to figure out the prevalence of AH, nevertheless as characteristics related to the presence of its hereditary facet among individuals aging between twenty four and seventy years from the urban region of town city in Democratic and well-liked Republic of African nation. Pulmonary high vital sign could also be a heavy condition that gets worse over time, but treatments can facilitate your symptoms so you will be able to live higher with the ill health. It ought to take some coming up with, but immeasurable people that have it notice ways that during which to undertake to all or any the things they love, as they did before they were diagnosed. Having internal organ vessel high vital sign (PAH) means that you have high level inside the arteries that go from your heart to your lungs. It’s very completely different from having regular high level. With PAH, the little arteriesin your lungs become slim or blocked. It's a lot ofsturdy for blood to flow through them that raises the pressure in your lungs. Your heart ought to work a lot of sturdy to pump blood through those arteries, and once a brief whereas the center muscle gets weak. Eventually, it'll lead to cardiovascular disease. Transversal study from January 2010 to January 2011, population- primarily based study, of 620 participants with sampling. For classification of AH, criteria enclosed vitalsign (BP) ≥ 140/90 mmHg or current use of medication medicine. People were interviewed with standardized questionnaires antecedently tested.
{"title":"A Short Note on Arterial cardiovascular disease","authors":"Lakshmi Vasudha","doi":"10.36648/2386-5180.21.9.355","DOIUrl":"https://doi.org/10.36648/2386-5180.21.9.355","url":null,"abstract":"Arterial high vital sign (AH) is taken into consideration as a public condition owing to its high prevalence and difficult management and it’s in addition depicted joined of the foremost very important risk factors for vas diseases. Thisstudy aimed to figure out the prevalence of AH, nevertheless as characteristics related to the presence of its hereditary facet among individuals aging between twenty four and seventy years from the urban region of town city in Democratic and well-liked Republic of African nation. Pulmonary high vital sign could also be a heavy condition that gets worse over time, but treatments can facilitate your symptoms so you will be able to live higher with the ill health. It ought to take some coming up with, but immeasurable people that have it notice ways that during which to undertake to all or any the things they love, as they did before they were diagnosed. Having internal organ vessel high vital sign (PAH) means that you have high level inside the arteries that go from your heart to your lungs. It’s very completely different from having regular high level. With PAH, the little arteriesin your lungs become slim or blocked. It's a lot ofsturdy for blood to flow through them that raises the pressure in your lungs. Your heart ought to work a lot of sturdy to pump blood through those arteries, and once a brief whereas the center muscle gets weak. Eventually, it'll lead to cardiovascular disease. Transversal study from January 2010 to January 2011, population- primarily based study, of 620 participants with sampling. For classification of AH, criteria enclosed vitalsign (BP) ≥ 140/90 mmHg or current use of medication medicine. People were interviewed with standardized questionnaires antecedently tested.","PeriodicalId":8195,"journal":{"name":"Annals of Clinical and Laboratory Research","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81911581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.36648/2386-5180.21.9.365
Gowthami Bainaboina
Dermatitis herpetiformis (DH) is an autoimmune bullous disease characterized by intensely pruritic, chronic, and recurrent vesicles on extensor surfaces such as the elbows, knees, and buttocks. The assortment of neutrophils at the papillary tips is the commonplace histopathological finding, and a trademark analytic element is granular immunoglobulin A statement in the papillary dermis by direct immunofluorescence. DH is firmly connected with gluten touchy enteropathy and is viewed as a cutaneous indication of gluten affectability; i.e., an extra-intestinal show of celiac illness. Gluten free eating routine is the primary line treatment for patients with DH and dispone is likewise compelling. DH specially influences Caucasians who convey human leukocyte antigen (HLA)- DQ2 or HLA-DQ8. The major autoantigen is epidermal transglutaminase. This survey centers around the affirmed highlights of DH and our new discoveries explicit to DH in Japanese patients.
{"title":"Dermatitis Herpetiformis: an Autoimmune Bullous Disease","authors":"Gowthami Bainaboina","doi":"10.36648/2386-5180.21.9.365","DOIUrl":"https://doi.org/10.36648/2386-5180.21.9.365","url":null,"abstract":"Dermatitis herpetiformis (DH) is an autoimmune bullous disease characterized by intensely pruritic, chronic, and recurrent vesicles on extensor surfaces such as the elbows, knees, and buttocks. The assortment of neutrophils at the papillary tips is the commonplace histopathological finding, and a trademark analytic element is granular immunoglobulin A statement in the papillary dermis by direct immunofluorescence. DH is firmly connected with gluten touchy enteropathy and is viewed as a cutaneous indication of gluten affectability; i.e., an extra-intestinal show of celiac illness. Gluten free eating routine is the primary line treatment for patients with DH and dispone is likewise compelling. DH specially influences Caucasians who convey human leukocyte antigen (HLA)- DQ2 or HLA-DQ8. The major autoantigen is epidermal transglutaminase. This survey centers around the affirmed highlights of DH and our new discoveries explicit to DH in Japanese patients.","PeriodicalId":8195,"journal":{"name":"Annals of Clinical and Laboratory Research","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76945445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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