Archives of gerontology and geriatrics最新文献

{"title":"Benefit of home-based virtual reality aerobic exercise combined with resistance training for reversing sarcopenia and reducing depression in community-dwelling older adults with sarcopenia: a randomized control trial","authors":"Kornanong Yuenyongchaiwat ,&nbsp;Chanakan Chitjamnogchai ,&nbsp;Natsinee Sermsinsaithong ,&nbsp;Wararat Tavonudomgit ,&nbsp;Lucksanaporn Mahawong ,&nbsp;Sasipa Buranapuntalug ,&nbsp;Preeyaphorn Songsorn ,&nbsp;Chusak Thanawattano","doi":"10.1016/j.archger.2025.106108","DOIUrl":"10.1016/j.archger.2025.106108","url":null,"abstract":"<div><h3>Background</h3><div>Sarcopenia is a growing concern owing to an aging global population. Older people with depression are at risk for sarcopenia and vice versa. Although physical exercise is key in preventing and managing sarcopenia, virtual reality (VR)-based exercises have emerged as an engaging alternative that may also alleviate depressive symptoms and enhance quality of life in older adults. However, the effects of VR exercise on depression in individuals with sarcopenia who are at higher risk of both physical decline and psychological distress remain underexplored.</div></div><div><h3>Objective</h3><div>This study aimed to explore the benefits of home-based VR aerobic exercise combined with resistance training for reversing sarcopenia and depression in community-dwelling older adults with sarcopenia.</div></div><div><h3>Methods</h3><div>This blinded randomized controlled trial enrolled 46 community-dwelling older adults with sarcopenia (37 females and 9 males); they were categorized into the home-based VR (<em>n</em> = 23) group receiving non-immersive VR aerobic exercise combined with a resistance program and the control group (CG) receiving self-care education (CG; <em>n</em> = 23). The VR program combined aerobic and resistance exercises, performed three times weekly for 12 weeks. Sarcopenia risk indicators, including gait speed, handgrip strength, skeletal muscle mass index (SMI), and depression scores, were examined before and after the intervention. A two-way mixed repeated-measures analysis of variance was performed.</div></div><div><h3>Results</h3><div>The VR group showed significant improvements in depressive symptoms (F(1,44)=51.80, <em>p</em>&lt; 0.001), SMI (F(1,44) =28.07, <em>p</em>&lt; 0.001), handgrip strength (F(1,44) = 66.74, <em>p</em>&lt; 0.001, np²=0.599), and gait speed (F(1,44)=0.67, <em>p</em>&lt; 0.001), whereas the CG showed reduced SMI (F(1,44) =7.55, <em>p</em>= 0.009) and handgrip strength F(1,44) =14.99, <em>p</em>&lt; 0.001).</div></div><div><h3>Conclusions</h3><div>Home-based VR aerobic exercise combined with resistance training improves muscle mass, muscle strength, and physical performance and reduces depression in older adults with sarcopenia. Thus, it may be applied to effectively prevent or reverse sarcopenia and decrease depression among older adults.</div></div><div><h3>Trial registration</h3><div>The Thai Clinical Trials Registry is TCTR20231005004.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"142 ","pages":"Article 106108"},"PeriodicalIF":3.8,"publicationDate":"2025-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145673039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes of multidimensional frailty among older adults during 2010–2023: A systematic review and cross-temporal meta-analysis","authors":"Huanle Liu ,&nbsp;Bin Chen ,&nbsp;Xianying Lu ,&nbsp;Shi Chen ,&nbsp;Huan Chen ,&nbsp;Xinyu Chen ,&nbsp;Dingxi Bai ,&nbsp;Xiaohui Dong ,&nbsp;Shirui Tang ,&nbsp;Jingyang Wang ,&nbsp;Chaoming Hou ,&nbsp;Jing Gao","doi":"10.1016/j.archger.2025.106092","DOIUrl":"10.1016/j.archger.2025.106092","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to explore the changing trend of multidimensional frailty among the elderly from 2010 to 2023 and its relationship with social changes.</div></div><div><h3>Study design</h3><div>This is a cross-temporal meta-analysis study.</div></div><div><h3>Methods</h3><div>From the establishment of each database to October 2024, eight databases were systematically searched, including PubMed, Web of Science, Embase, CINAHL, China National Knowledge Infrastructure (CNKI), China Science and Technology Journal Database (VIP), Wanfang Database, and SinoMed Database. Two researchers independently screened the studies and extracted the data. Data analysis was conducted using SPSS version 26.0 through correlation analysis and linear regression.</div></div><div><h3>Results</h3><div>96 studies involving 79,810 individuals were ultimately included. The results showed an increasing trend in multidimensional frailty in older adults over time (<em>β</em>= 0.088 to 0.225, all <em>p</em>-values &lt;0.05), and the effect size <em>d</em> varied between 0.23 and 0.7. The predicted mean TFI total score increased from 5.49 in 2010 to 7.21 in 2023. Subgroup analyses showed a more pronounced increasing trend in the levels of multidimensional frailty in older adults in females (<em>β</em>=0.135), and that levels of multidimensional frailty in older adults in community-based (d = 0.55) and institutionalized settings (<em>d</em>=-0.53) were more strongly affected by the year, whereas hospital-sourced older adults (d = 0.39) were less affected. The level of multidimensional frailty among older adults in Asia has declined (<em>β</em>=-0.015), while Europe showed an upward trend (<em>β</em>=0.077). Meanwhile, lagged analyses showed that the correlations between multidimensional frailty scores and the three types of social indicators (economic status, social support, and health care) were mostly significantly positive.</div></div><div><h3>Conclusions</h3><div>Between 2010 and 2023, multidimensional frailty in the elderly showed an upward trend, as well as economic status, social support, and medical care were associated with the rising level of multidimensional frailty in the elderly. Future research should integrate individual-level health management with macro-level social and economic policies, considering factors such as gender, region, and sample source, to develop personalized intervention programs that effectively enhance the overall health and well-being of older adults.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"142 ","pages":"Article 106092"},"PeriodicalIF":3.8,"publicationDate":"2025-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145673005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Latent transition of social participation and its relationship with frailty among older adults with chronic non-communicable diseases in China: A national longitudinal study","authors":"Zitong Gao ,&nbsp;Haihong Qin ,&nbsp;Tong Yue ,&nbsp;Ye Li ,&nbsp;Miao Huo","doi":"10.1016/j.archger.2025.106091","DOIUrl":"10.1016/j.archger.2025.106091","url":null,"abstract":"<div><h3>Objective</h3><div>Older adults’ social participation is associated with frailty, but the transition patterns and their relationship with frailty remain unclear. This longitudinal study aims to explore the latent classes and transition patterns of social participation in older adults with chronic non-communicable diseases and to assess their relationship with subsequent frailty.</div></div><div><h3>Method</h3><div>The data set from the China Health and Retirement Longitudinal Study (CHARLS) in 2018 (T1) and 2020 (T2) was analyzed, including 4793 older adults. Latent profile analyses (LPA) and latent transition analyses (LTA) were employed to identify latent classes and the transition probabilities of social participation at T1 and T2. The ANCOVA was employed to examine the frailty index at T2 was compared across transition patterns.</div></div><div><h3>Results</h3><div>The LPA results supported a 4-class model labeled as inactive group, voluntary group, social interaction group, and omni-engaged group. The probability of transition from the other groups to the inactive group was significant (33.3 %, 53.8 %, 54.4 %). Age, residence, marital status, and other demographic characteristics can significantly impact transition patterns. However, after controlling for baseline frailty and other covariates, transition patterns were not significantly associated with T2 frailty levels.</div></div><div><h3>Conclusion</h3><div>The short-term (two-year) effect of qualitative shifts in social participation on frailty may be limited when pre-existing health status is accounted for. Future interventions should prioritize sustained engagement and investigate the longer-term effects of both qualitative and quantitative changes in social participation.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"142 ","pages":"Article 106091"},"PeriodicalIF":3.8,"publicationDate":"2025-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145622201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mortality prediction among older people in primary care: a comparison of predictive performance of the frailty index with regression-based and machine learning models","authors":"Collin JC Exmann ,&nbsp;Karlijn J Joling ,&nbsp;Robert Verheij ,&nbsp;Iris van der Heide ,&nbsp;Hein PJ van Hout ,&nbsp;Emiel O Hoogendijk","doi":"10.1016/j.archger.2025.106096","DOIUrl":"10.1016/j.archger.2025.106096","url":null,"abstract":"<div><h3>Introduction</h3><div>The frailty index is widely used to identify vulnerable individuals at risk of adverse outcomes like mortality. However, its predictive performance compared to other mortality prediction models, especially in subpopulations like people with dementia, is not well known. This study aimed to compare frailty index’s performance with regression-based and machine learning models for predicting mortality among community-dwelling older adults, and to test performance in a dementia subgroup.</div></div><div><h3>Methods</h3><div>We selected 355,958 community-dwelling adults aged 60 years and older from primary care with electronic health records (EHR) linked to mortality registrations. We developed one- and five-year mortality prediction models using a 36-item frailty index and compared discrimination and calibration of a regression model including the frailty index with two types of regression models and two types of machine learning models using single health deficits as predictors. Lastly, we evaluated the models’ performance in 6394 persons with dementia.</div></div><div><h3>Results</h3><div>The frailty index model showed moderate performance with an AUC-ROC of 0.793 and 0.804 for one- and five-year mortality. The other models, using the single deficits as predictors, reached higher AUC-ROCs up to 0.828 and 0.824, with good calibration. Overall, the models performed worse in the dementia subgroup, with AUC-ROCs between 0.678 and 0.704.</div></div><div><h3>Discussion</h3><div>Regression-based and machine learning prediction models using single frailty deficits outperform the frailty index in predicting one- and five-year mortality. However, these models can be more complex and less interpretable. We found lower performance for people with dementia, suggesting the models are less applicable in this subpopulation.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"142 ","pages":"Article 106096"},"PeriodicalIF":3.8,"publicationDate":"2025-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145622345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Timing of daily physical activity and onset of depressive symptoms: A longitudinal cohort study of community-dwelling older adults","authors":"Masanori Morikawa ,&nbsp;Kenji Harada ,&nbsp;Chiharu Nishijima ,&nbsp;Kazuya Fujii ,&nbsp;Daisuke Kakita ,&nbsp;Takuto Okuya ,&nbsp;Kazuki Soma ,&nbsp;Yukari Yamashiro ,&nbsp;Naoto Takayanagi ,&nbsp;Motoki Sudo ,&nbsp;Hiroyuki Shimada","doi":"10.1016/j.archger.2025.106095","DOIUrl":"10.1016/j.archger.2025.106095","url":null,"abstract":"<div><h3>Background</h3><div>Late-life depression is a major public-health concern. Although physical activity is protective, the longitudinal association of physical-activity timing on depressive-symptom onset in older adults remains unclear. We examined the association of physical activity timing with depressive symptoms in older adults.</div></div><div><h3>Methods</h3><div>This study included 2542 community-dwelling adults aged ≥60 years from the NCGG-SGS cohort who were free of depressive symptoms at baseline. Physical activity was measured using an accelerometer and summarized in three-hour intervals. Functional principal component analysis classified participants into early and late active groups. Depressive symptoms (GDS score ≥5) were assessed after 26.4 months. Risk differences were estimated using inverse probability and overlap weighting, adjusting for demographic, health, and lifestyle factors.</div></div><div><h3>Results</h3><div>Depressive symptoms developed in 14.7% of participants. The late active group (activity peak in the afternoon) had a lower incidence (10.1%) than the early active group (16.1%). After inverse probability weighting, the risk difference was −3.9% (95% CI: −7.0% to −0.8%, <em>P</em>= 0.009). After overlap weighting, the risk difference was −3.5% (95% CI: −6.6% to −0.4%, <em>P</em>= 0.011). Subgroup analyses showed consistent results across age, sex, and activity levels.</div></div><div><h3>Conclusions</h3><div>A late active pattern was associated with a reduced risk of depressive symptoms in older adults. Timing of daily activity should be considered in depression-prevention strategies.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"142 ","pages":"Article 106095"},"PeriodicalIF":3.8,"publicationDate":"2025-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145622346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trajectory of depressive symptom before and after incident hearing loss: A 24-year population-based longitudinal cohort study","authors":"Qin Li ,&nbsp;Haohong Lai ,&nbsp;Juntao Wu ,&nbsp;Haidi Yang","doi":"10.1016/j.archger.2025.106090","DOIUrl":"10.1016/j.archger.2025.106090","url":null,"abstract":"<div><h3>Background</h3><div>Although hearing loss (HL) is a known risk factor for depressive symptoms, how depressive symptoms progress after its onset remains insufficiently explored. This study aimed to explore whether incident HL is associated with an acute increase and a sustained progress in depressive symptoms, after accounting for pre-HL depressive trajectories.</div></div><div><h3>Methods</h3><div>Using longitudinal data from the Health and Retirement Study (1998–2022), depressive symptoms were assessed biennially using the 8-item Center for Epidemiologic Studies Depression Scale (CES-D). Linear mixed-effects models were employed to estimate acute changes at the time of HL onset and the annual rate of change in depressive symptoms post-HL, while adjusting for pre-HL trajectories and baseline covariates.</div></div><div><h3>Results</h3><div>Among 11,099 participants (mean age 64.8 years), 3024 developed incident HL over a mean follow-up of 15.7 years. Prior to HL onset, the annual increase in depressive symptoms did not differ significantly between those who developed HL and those who remained free of HL. Following HL onset, a significant acute increase in depressive symptoms was observed (β = 0.234; 95 % CI: 0.184 to 0.283). Additionally, there was a sustained acceleration in the annual rate of increase in depressive symptoms post-HL (β = 0.013/year; 95 % CI: 0.005 to 0.022).</div></div><div><h3>Conclusions</h3><div>Incident HL is associated with an immediate increase and a long-term progress in depressive symptoms, independent of pre-onset trajectories. These findings highlight HL as a preventable risk factor for late-life depressive symptoms and underscore the importance of early detection and intervention for hearing to mitigate depressive symptom risk in aging populations.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"142 ","pages":"Article 106090"},"PeriodicalIF":3.8,"publicationDate":"2025-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145622344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of vitamin D intake alone on elderly body composition: A systematic review and meta-analysis of RCTs","authors":"Tomoyuki Matsuyama,&nbsp;Hiroshi Okada,&nbsp;Yuto Saijo,&nbsp;Yuka Hasegawa,&nbsp;Hanako Nakajima,&nbsp;Takuro Okamura,&nbsp;Rieko Nakatani,&nbsp;Emi Ushigome,&nbsp;Naoko Nakanishi,&nbsp;Masahide Hamaguchi,&nbsp;Michiaki Fukui","doi":"10.1016/j.archger.2025.106093","DOIUrl":"10.1016/j.archger.2025.106093","url":null,"abstract":"<div><h3>Background</h3><div>This study investigated the effect of vitamin D on body composition in individuals aged 60 years and older.</div></div><div><h3>Methods</h3><div>PubMed, Embase, and Cochrane databases were searched from inception to April 22, 2024, for randomized controlled trials reporting skeletal muscle mass index (SMI), lean mass (LM), handgrip strength, and fat mass (FM) as primary or secondary outcomes in elderly individuals with a mean age of 60 years or older were included. The primary outcome was the change in SMI between vitamin D and control groups; secondary outcomes were changes in LM, FM, and handgrip strength.</div></div><div><h3>Results</h3><div>Seven randomized controlled trials met eligibility criteria. Mean age ranged from 60 to 74 years, participants ranged from 50 to 1094, and study durations ranged from 3 to 36 months. The mean baseline 25(OH)D concentration ranged from 15.1 to 33.0 ng/mL. The vitamin D intake group was not associated with an increase in SMI, LM, or handgrip strength compared to the control group, although a decrease in FM was observed. In the meta-analysis excluding studies that used active vitamin D, the vitamin D intake group was not associated with increases in SMI, LM, or handgrip strength, nor with a decrease in FM compared to the control group.</div></div><div><h3>Conclusion</h3><div>In the present study, vitamin D intake did not increase SMI, LM, or handgrip strength in the elderly individuals, although a possible decrease in FM was observed. Further studies are needed to better elucidate the effects of vitamin D on body composition in the elderly.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"142 ","pages":"Article 106093"},"PeriodicalIF":3.8,"publicationDate":"2025-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145622202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of gut microbiota and arginine-agmatine metabolism with postoperative delirium in elderly patients following lower limb fracture surgery: a prospective nested case-control study","authors":"Xinyu Cao,&nbsp;Jing Wang,&nbsp;Yv Zhang,&nbsp;Jing Zhang,&nbsp;Jianli Li","doi":"10.1016/j.archger.2025.106094","DOIUrl":"10.1016/j.archger.2025.106094","url":null,"abstract":"<div><h3>Objective</h3><div><strong>:</strong> This study aimed to investigate the role of gut microbiota and arginine-agmatine metabolic levels in the pathogenesis of postoperative delirium (POD) in elderly patients following lower limb fracture surgery.</div></div><div><h3>Methods</h3><div><strong>:</strong> This prospective nested case-control study enrolled 111 patients aged ≥65 years who were scheduled for elective lower limb orthopedic surgery. POD was assessed twice daily (08:00–10:00 and 18:00–20:00) using the Confusion Assessment Method-Chinese Reversion (CAM-CR). Thirty patients who developed POD were matched to thirty non-POD patients via propensity score matching (PSM). Fecal samples collected one day preoperatively underwent gut microbiota analysis using 16S rRNA gene sequencing, with α-diversity, β-diversity, and linear discriminant analysis effect size (LEfSe) analyses performed. Additionally, fasting venous blood samples collected one day preoperatively were analyzed by ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) to quantify plasma levels of arginine, agmatine, putrescine, spermidine, and spermine. Spearman correlation analysis was performed to explore associations between differential bacterial genus abundance, arginine-agmatine metabolite levels, and CAM-CR scores.</div></div><div><h3>Results</h3><div><strong>:</strong> Compared to controls, the POD group showed significantly altered gut microbiota β-diversity (P &lt; 0.001) but no change in α-diversity. At the genus level, LEfSe analysis revealed increased abundance of <em>Megasphaera</em> and <em>Clostridium innocuum group</em>, and decreased abundance of <em>Paraprevotella</em> and <em>Akkermansia</em> in the POD group. Additionally, the POD group exhibited significantly elevated arginine levels (P = 0.044) and reduced agmatine (P = 0.016) and spermine (P = 0.005) levels. Correlation analysis demonstrated that arginine levels were positively correlated with <em>Megasphaera</em> abundance and CAM-CR score, but negatively correlated with <em>Paraprevotella</em> and <em>Akkermansia</em> abundance; agmatine concentrations were positively correlated with <em>Akkermansia</em> abundance but negatively correlated with CAM-CR score; putrescine levels were negatively correlated with <em>Clostridium innocuum group</em> abundance; spermine levels were positively correlated with <em>Paraprevotella</em> abundance but negatively correlated with CAM-CR score. CAM-CR score was negatively associated with <em>Akkermansia</em> abundance and positively associated with <em>Megasphaera</em> abundance (all P &lt; 0.05).</div></div><div><h3>Conclusions</h3><div><strong>:</strong> Gut microbiota and arginine-agmatine metabolism are associated with the pathogenesis of POD in elderly lower limb fracture patients, though their precise mechanistic roles require further investigation.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"142 ","pages":"Article 106094"},"PeriodicalIF":3.8,"publicationDate":"2025-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145622200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single-cell transcriptomic analysis reveals the molecular alterations of endothelial cells during ageing","authors":"Yongle Sun ,&nbsp;Yini Dai ,&nbsp;Yehu Yin","doi":"10.1016/j.archger.2025.106088","DOIUrl":"10.1016/j.archger.2025.106088","url":null,"abstract":"<div><div>Ageing of the vasculature is the fundamental cause for the development of cardiovascular diseases. Endothelial cells play an important role in ageing of the cardiovascular system, but the potential mechanisms of vascular ageing and the molecular changes of endothelial cells during ageing remain unclear. Here, we analyzed the cellular and molecular alterations of endothelial cells in young and aged aortas using single-cell transcriptome analysis. We identified 191 up-regulated genes and 282 down-regulated genes between old and young group. We found that most of the down-regulated genes were mainly enriched in normal biological pathways and some stress response pathways. Protein–protein interaction and transcription factor analysis revealed that AP-1 and Egr1 might be the key transcription factors related to vascular ageing. We proposed that ageing is resulted from the gradual loss of normal functional genes. Our research provides new ideas for further understanding the mechanism of ageing.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"142 ","pages":"Article 106088"},"PeriodicalIF":3.8,"publicationDate":"2025-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145650373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between frailty and white matter hyperintensities: A systematic review and meta-analysis","authors":"Xuzi Li,&nbsp;Anling Luo,&nbsp;Yiting Deng,&nbsp;Yujia Yang,&nbsp;Qin Yang,&nbsp;Yujie Chen,&nbsp;Li He,&nbsp;Muke Zhou","doi":"10.1016/j.archger.2025.106089","DOIUrl":"10.1016/j.archger.2025.106089","url":null,"abstract":"<div><h3>Background</h3><div>Frailty, common in aging, contributes to cognitive and motor decline. White matter hyperintensity (WMH), markers of cerebral small vessel disease, show similar effects. Although studies suggest an association between frailty and WMH, the evidence is inconsistent, and their relationship remains uncertain.</div></div><div><h3>Objective</h3><div>This research aimed to examine the relationship between frailty and WMH.</div></div><div><h3>Methods</h3><div>Systematic literature search and meta-analytic methods were employed. Study screening and data extraction were conducted, and quality assessment was performed using the Newcastle-Ottawa Scale and American Agency for Healthcare Research and Quality evaluation tools. StataSE 15.0 software was utilized to carry out statistical analyses.</div></div><div><h3>Results</h3><div>Nine articles, including 10 studies, were included. The meta-analysis results demonstrated a significant positive relationship between WMH and frailty (odds ratio [OR] = 1.38, 95 % confidence interval [CI]: 1.17–1.64, <em>P</em> &lt; 0.001). Subgroup analysis showed a consistent association between WMH and frailty, which was stronger in hospitalized patients, Asian populations, and studies using the Fried or Fazekas criteria. Sensitivity analyses validated the robustness of the results. After adjustment for publication bias via the trim-and-fill method, the association was still significant (OR = 1.25, 95 % CI: 1.05–1.50, <em>P</em> = 0.012), though limitations of this method and other potential biases should be considered.</div></div><div><h3>Conclusions</h3><div>WMH is significantly associated with frailty, offering new insights into its potential role in frailty. This meta-analysis suggests that WMH is worth exploring in future longitudinal studies to understand its relevance to frailty mechanisms.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"142 ","pages":"Article 106089"},"PeriodicalIF":3.8,"publicationDate":"2025-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145584311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}