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Correction to: Research on the selfefficacy and resilience of female graduate students in the era of artificial intelligence: analysis of the mechanism of mobile phone dependence, anxiety and mentoring relationship.
IF 3.2 3区 医学 Q2 PSYCHIATRY Pub Date : 2025-01-23 DOI: 10.1007/s00737-025-01556-3
Xianjie Peng, Ruwei Nie, Sihan Tong
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引用次数: 0
The pregnant moms' empowerment program - Mexico enhances mental health for women exposed to intimate partner violence: a pilot randomized controlled trial. 墨西哥孕妇赋权项目提高遭受亲密伴侣暴力的妇女的心理健康:一项随机对照试验试点。
IF 3.2 3区 医学 Q2 PSYCHIATRY Pub Date : 2025-01-21 DOI: 10.1007/s00737-024-01549-8
Cecilia Martinez-Torteya, Laura E Miller-Graff, Jessica R Carney, Sandra P Esparza-Dávila, Jessica C Acuapa-Juárez, Kathryn H Howell

Purpose: Given the lack of available and effective interventions to address the detrimental consequences of perinatal exposure to intimate partner violence (IPV) on maternal mental health, and reported very low access to IPV-related mental health services in Mexico, we examined the feasibility and efficacy of a culturally adapted, virtual, brief group psychosocial intervention designed to improve maternal mental and physical health and reduce IPV revictimization for pregnant women exposed to IPV. In this pilot randomized controlled trial, we evaluated maternal outcomes after participation in the Pregnant Moms' Empowerment Program (PMEP) in Mexico.

Methods: Women were recruited from social service agencies and health centers in the community, as well as social media advertisements that targeted pregnant women living in Mexico. Women were randomized to receive the intervention (n = 43) or a control condition (i.e., referrals to local services; n = 47). Women completed questionnaires at baseline, post-intervention, and 3-months postpartum that assessed their exposure to IPV, depression, posttraumatic stress symptoms (PTSS), physical health symptoms, and resilience, as these were our primary outcomes of interest. Women in the intervention condition participated in ten, 60-minute virtual group sessions. Multilevel models were used to evaluate effects of treatment over time.

Results: On average, women in the intervention condition participated in six treatment sessions. Compared to the control group, intervention participants reported significantly fewer symptoms of depression at both the post-intervention and 3-month postpartum assessments (d = 0.64, d = 0.59, respectively) and fewer physical health symptoms at the post-intervention assessment (d = 0.77). Trend-level improvements in PTSS scores for post-intervention (d = 0.56) and 3-months postpartum (d = 0.56), as well as physical health at 3-months postpartum (d = 0.59), were also observed. There were no group differences in exposure to IPV over time.

Conclusion: The current study adds to the evidence base for the PMEP intervention while also expanding it to a new cultural context by suggesting promise of its clinical utility in targeting Mexican women's perinatal depression, PTSS, and physical health symptoms.

目的:鉴于缺乏可用和有效的干预措施来解决围产期暴露于亲密伴侣暴力(IPV)对孕产妇心理健康的有害影响,并且据报道,墨西哥获得与亲密伴侣暴力相关的心理健康服务的机会非常低,我们研究了一种文化适应的、虚拟的、简短的群体心理社会干预的可行性和有效性,该干预旨在改善孕产妇身心健康,减少暴露于亲密伴侣暴力的孕妇再次受害。在这项随机对照试验中,我们评估了参加墨西哥孕妇赋权计划(PMEP)后的产妇结局。方法:从社区的社会服务机构和卫生中心以及针对居住在墨西哥的孕妇的社交媒体广告中招募妇女。妇女被随机分为干预组(n = 43)或对照组(即转介到当地服务机构;n = 47)。妇女在基线、干预后和产后3个月完成问卷调查,评估她们暴露于IPV、抑郁、创伤后应激症状(PTSS)、身体健康症状和恢复力,因为这些是我们感兴趣的主要结果。干预组的女性参加了10次60分钟的虚拟小组会议。多水平模型用于评估治疗的长期效果。结果:干预组的女性平均参加了6次治疗。与对照组相比,干预组在干预后和产后3个月评估中报告的抑郁症状明显减少(d = 0.64, d = 0.59),干预后评估中身体健康症状明显减少(d = 0.77)。还观察到干预后(d = 0.56)和产后3个月(d = 0.56) ptsd评分的趋势水平改善,以及产后3个月的身体健康状况(d = 0.59)。随着时间的推移,暴露于IPV的情况没有组间差异。结论:目前的研究增加了PMEP干预的证据基础,同时也通过表明其在针对墨西哥妇女围产期抑郁症、创伤后应激障碍和身体健康症状的临床应用前景,将其扩展到新的文化背景。
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引用次数: 0
Integrated care for multi-domain vulnerability during pregnancy: a retrospective cohort study. 孕期多领域脆弱性的综合护理:一项回顾性队列研究。
IF 3.2 3区 医学 Q2 PSYCHIATRY Pub Date : 2025-01-17 DOI: 10.1007/s00737-024-01554-x
Sushma C Munshi, Eline C I Hoex, Anne Marie Weggelaar-Jansen, Esther M Knijff, Eline C van der Wilk, Eric A P Steegers, Hilmar H Bijma

Purpose: Psychosocial risk factors are frequently present in pregnant women and are associated with adverse maternal and neonatal outcomes. Professional guidelines recommend early detection of vulnerability and provision of multidisciplinary care, including an integrated care plan for pregnant women with social factors, such as residing in deprived areas, teenage pregnancy, and psychiatric illness. However, to date, such approach is impeded by lack of data on co-occurrence of vulnerability. Therefore, we aim to describe co-occurrence of psychiatric illness, social factors or substance use during pregnancy.

Methods: A retrospective cohort study of 1002 pregnant women referred for evaluation by a multidisciplinary team because of psychiatric illness, social factors or substance use in a university hospital in a large city in the Netherlands. Data from medical charts between January 2017 and May 2022 were extracted and analyzed by univariate and bivariate analysis.

Results: Multi-domain vulnerability was present in 83% of women and most frequently involved the following patterns: psychiatric illness with social factors and chronic physical illness (24%), psychiatric illness with social factors (14%), social factors with chronic physical illness (13%) and psychiatric illness with chronic physical illness (12%). Single-domain vulnerability was present in 17% of women, involving most frequently social factors (9%) and psychiatric illness (8%).

Conclusion: The majority of women with psychiatric illness, social factors or substance use have multi-domain vulnerability. There is a need for a novel approach to care to address vulnerability in pregnant women.

目的:心理社会风险因素经常存在于孕妇中,并与不良的孕产妇和新生儿结局相关。专业指南建议及早发现脆弱性并提供多学科护理,包括为有社会因素的孕妇制定综合护理计划,如居住在贫困地区、少女怀孕和精神疾病。然而,迄今为止,由于缺乏关于脆弱性同时发生的数据,这种办法受到阻碍。因此,我们的目的是描述在怀孕期间精神疾病,社会因素或物质使用的共同发生。方法:对荷兰某大城市大学医院1002名因精神疾病、社会因素或药物使用而被多学科小组转诊评估的孕妇进行回顾性队列研究。从2017年1月至2022年5月的医学图表中提取数据,并通过单因素和双因素分析进行分析。结果:83%的女性存在多领域脆弱性,最常见的脆弱性模式为精神疾病伴社会因素和慢性身体疾病(24%)、精神疾病伴社会因素(14%)、社会因素伴慢性身体疾病(13%)和精神疾病伴慢性身体疾病(12%)。17%的妇女存在单一领域的脆弱性,最常见的是社会因素(9%)和精神疾病(8%)。结论:大多数患有精神疾病、社会因素或物质使用的女性存在多领域脆弱性。需要一种新的护理方法来解决孕妇的脆弱性问题。
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引用次数: 0
Gestational diabetes and mental health: longitudinal analysis of data from the GEMS randomized trial. 妊娠期糖尿病与心理健康:GEMS随机试验数据的纵向分析
IF 3.2 3区 医学 Q2 PSYCHIATRY Pub Date : 2025-01-15 DOI: 10.1007/s00737-024-01551-0
Phyllis Ohene-Agyei, Greg D Gamble, Thach Tran, Jane E Harding, Caroline A Crowther

Purpose: There is limited high-quality evidence about perinatal mental health among women with gestational diabetes. We aimed to assess the risks and longitudinal changes in anxiety, depression, and health-related quality of life comparing women with gestational diabetes and those without among a contemporary cohort of pregnant women.

Methods: Prospective cohort study of participants in the GEMS Trial. Women with a singleton pregnancy were eligible if they had a 75-g diagnostic oral glucose-tolerance test between 24 and 32 weeks' gestation, provided written informed consent, and completed questionnaires about anxiety, depression, and health-related quality of life at the study time points.

Results: There were no differences in risk for anxiety (RR 1.13, 95% CI 0.86, 1.49; p = 0.39) or depression (RR 1.08, 95% CI 0.78, 1.50; p = 0.64) between the two groups at 36 weeks' gestation or 6 months postpartum [anxiety: (RR 1.21, 95% CI 0.90, 1.63; p = 0.21); depression: (RR 0.84, 95% CI 0.55, 1.28; p = 0.43]. However, at 36 weeks' gestation participants with gestational diabetes reported better physical functioning, and at 6 months postpartum, better mental functioning (mean difference (MD) in scores 1.28, 95% CI 0.25, 2.30; p = 0.01) although worse physical functioning (MD -2.99, 95% CI -3.90, -2.07; p = < 0.001) compared to participants without.

Conclusion: The risk for poor mental health during the perinatal period does not differ importantly among women diagnosed and treated for gestational diabetes compared to the general pregnant population.

目的:关于妊娠糖尿病妇女围产期心理健康的高质量证据有限。我们的目的是评估在当代孕妇队列中,比较妊娠期糖尿病妇女和无妊娠糖尿病妇女在焦虑、抑郁和健康相关生活质量方面的风险和纵向变化。方法:对GEMS试验参与者进行前瞻性队列研究。单胎妊娠妇女如果在妊娠24至32周期间进行75克诊断性口服葡萄糖耐量试验,提供书面知情同意,并在研究时间点完成关于焦虑、抑郁和健康相关生活质量的问卷调查,则符合条件。结果:两组患者焦虑风险无差异(RR 1.13, 95% CI 0.86, 1.49;p = 0.39)或抑郁(RR 1.08, 95% CI 0.78, 1.50;p = 0.64),两组在妊娠36周或产后6个月的焦虑差异(RR 1.21, 95% CI 0.90, 1.63;p = 0.21);抑郁:(RR 0.84, 95% CI 0.55, 1.28;p = 0.43]。然而,在妊娠36周时,患有妊娠糖尿病的参与者报告了更好的身体功能,在产后6个月时,报告了更好的心理功能(平均差异(MD)评分1.28,95% CI 0.25, 2.30;p = 0.01),但身体功能较差(MD -2.99, 95% CI -3.90, -2.07;p =结论:在诊断和治疗过妊娠糖尿病的妇女中,围产期心理健康状况不佳的风险与一般妊娠人群相比没有显著差异。
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引用次数: 0
Research on the self-efficacy and resilience of female graduate students in the era of artificial intelligence: analysis of the mechanism of mobile phone dependence, anxiety and mentoring relationship.
IF 3.2 3区 医学 Q2 PSYCHIATRY Pub Date : 2025-01-07 DOI: 10.1007/s00737-024-01547-w
Xianjie Peng, Ruwei Nie, Sihan Tong

Purpose: The purpose of this study is to investigate the impact of the employment situation on the anxiety levels and research self-efficacy of graduate students, with a particular focus on female graduate students. The study aims to understand how the use of AIGC tools, which has become more frequent among those with lower research self-efficacy, affects anxiety and research resilience. Additionally, the research explores the role of the mentoring relationship in influencing the psychological and academic experiences of female graduate students.

Method: The research involved 1164 female master's and doctoral students and employed a moderated chain mediation model. This model was constructed based on social cognitive theory and Habermas interaction theory to analyze the relationships between research self-efficacy, mobile phone dependence, anxiety, and research resilience. Data was collected and empirically analyzed using SPSS 26.0, a statistical software, to examine the proposed relationships and the moderating effect of the mentoring relationship.

Result: The findings revealed that scientific research self-efficacy positively influences research resilience among female graduate students. Additionally, mobile phone dependence and anxiety were found to play a chain mediating role between self-efficacy and research resilience. The study also discovered that the mentoring relationship negatively moderated the effects of mobile phone dependence and anxiety on these students.

Conclusion: Based on the results, the study concludes that mentors and academic administrators should consider the research capabilities and interests of students when assigning research tasks. It is recommended to establish a flight instructor mentorship system that maximizes the strengths of each mentor to support students, especially those with suboptimal mentor-mentee relationships. This approach could help in providing positive guidance and improving the research resilience of female graduate students who are more susceptible to anxiety and mobile phone dependence.

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引用次数: 0
Links among maternal antenatal attachment, postnatal depressive symptoms and infant crying: a prospective cohort study. 母亲产前依恋、产后抑郁症状和婴儿哭闹之间的联系:一项前瞻性队列研究
IF 3.2 3区 医学 Q2 PSYCHIATRY Pub Date : 2025-01-06 DOI: 10.1007/s00737-024-01550-1
Laura Lærkegård Støve, Ruth Kirk Ertmann, Volkert Dirk Siersma, Sarah Strøyer de Voss, Johanne Smith-Nielsen

Purpose: This study investigated whether maternal antenatal attachment (MAA) in the third trimester was associated with self-reported problematic infant crying at eight weeks postnatally and explored links with postnatal depressive symptoms.

Methods: A prospective cohort study was conducted with 1287 pregnant participants in Danish general practice. MAA was measured using the Maternal Antenatal Attachment Scale (MAAS) in the third trimester. Both postnatal depressive symptoms and infant crying problems were assessed eight weeks postnatally, using the Edinburgh Postnatal Depression Scale (EPDS) and maternal reports, respectively.

Results: Low MAAS quality scores in the third trimester were initially associated with a 51% increased risk of reporting problematic infant crying at eight weeks, but this effect disappeared after adjusting for physical and mental health variables (e.g., chronic disease, anxiety, and depression symptoms) during pregnancy. No significant effects were found for MAAS intensity or total score. Low MAAS quality and overall MAAS scores were associated with an increased risk of scoring above cutoff on the EPDS. High levels of postnatal depressive symptoms at eight weeks significantly increased the likelihood of reporting problematic infant crying. Low MAAS scores combined with high levels of postnatal depressive symptoms did not increase the risk of problematic infant crying compared to low levels of depressive symptoms with low MAAS scores.

Conclusions: Our findings highlight the importance of considering maternal mental health when parents report infant crying problems postnatally. Furthermore, our results demonstrate that poor MAA in pregnancy is not necessarily linked with parental report of problematic infant crying after birth.

目的:本研究探讨了孕晚期母亲产前依恋(MAA)是否与产后8周自我报告的问题婴儿哭闹有关,并探讨了其与产后抑郁症状的联系。方法:对丹麦全科医院1287名孕妇进行前瞻性队列研究。在妊娠晚期采用母体产前依恋量表(MAAS)测量MAA。产后8周后,分别使用爱丁堡产后抑郁量表(EPDS)和产妇报告对产后抑郁症状和婴儿哭闹问题进行评估。结果:低MAAS质量评分在妊娠晚期最初与8周报告问题婴儿哭闹的风险增加51%相关,但在调整了怀孕期间的身心健康变量(如慢性疾病、焦虑和抑郁症状)后,这种影响消失了。未发现MAAS强度或总分有显著影响。低MAAS质量和总体MAAS评分与EPDS评分高于临界值的风险增加有关。高水平的产后抑郁症状在八周显著增加报告问题婴儿哭闹的可能性。与低MAAS评分的低抑郁症状相比,低MAAS评分合并高水平的产后抑郁症状并不会增加问题婴儿哭闹的风险。结论:我们的研究结果强调了在父母报告婴儿产后哭闹问题时考虑母亲心理健康的重要性。此外,我们的研究结果表明,怀孕期间不良的MAA与父母报告的婴儿出生后有问题的哭泣并不一定相关。
{"title":"Links among maternal antenatal attachment, postnatal depressive symptoms and infant crying: a prospective cohort study.","authors":"Laura Lærkegård Støve, Ruth Kirk Ertmann, Volkert Dirk Siersma, Sarah Strøyer de Voss, Johanne Smith-Nielsen","doi":"10.1007/s00737-024-01550-1","DOIUrl":"https://doi.org/10.1007/s00737-024-01550-1","url":null,"abstract":"<p><strong>Purpose: </strong>This study investigated whether maternal antenatal attachment (MAA) in the third trimester was associated with self-reported problematic infant crying at eight weeks postnatally and explored links with postnatal depressive symptoms.</p><p><strong>Methods: </strong>A prospective cohort study was conducted with 1287 pregnant participants in Danish general practice. MAA was measured using the Maternal Antenatal Attachment Scale (MAAS) in the third trimester. Both postnatal depressive symptoms and infant crying problems were assessed eight weeks postnatally, using the Edinburgh Postnatal Depression Scale (EPDS) and maternal reports, respectively.</p><p><strong>Results: </strong>Low MAAS quality scores in the third trimester were initially associated with a 51% increased risk of reporting problematic infant crying at eight weeks, but this effect disappeared after adjusting for physical and mental health variables (e.g., chronic disease, anxiety, and depression symptoms) during pregnancy. No significant effects were found for MAAS intensity or total score. Low MAAS quality and overall MAAS scores were associated with an increased risk of scoring above cutoff on the EPDS. High levels of postnatal depressive symptoms at eight weeks significantly increased the likelihood of reporting problematic infant crying. Low MAAS scores combined with high levels of postnatal depressive symptoms did not increase the risk of problematic infant crying compared to low levels of depressive symptoms with low MAAS scores.</p><p><strong>Conclusions: </strong>Our findings highlight the importance of considering maternal mental health when parents report infant crying problems postnatally. Furthermore, our results demonstrate that poor MAA in pregnancy is not necessarily linked with parental report of problematic infant crying after birth.</p>","PeriodicalId":8369,"journal":{"name":"Archives of Women's Mental Health","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142930487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Psychometric evaluation of the Yale-Brown Obsessive-Compulsive Scale in pregnant women. 孕妇耶鲁-布朗强迫症量表的心理测量评估。
IF 3.2 3区 医学 Q2 PSYCHIATRY Pub Date : 2025-01-02 DOI: 10.1007/s00737-024-01548-9
Catherine E Rast, Rashelle Musci, Jonathan S Abramowitz, Gerald Nestadt, Mary C Kimmel, Tracey Dibbs, Lauren M Osborne, Jack Samuels, Janice Krasnow, Eric A Storch

Purpose: Although many women experience obsessive-compulsive symptoms during the perinatal period, the Yale-Brown Obsessive Compulsive Scale (YBOCS) has not yet been psychometrically evaluated in this population. This study examined the internal consistency, convergent and divergent validity, and factor structure of the YBOCS among pregnant women.

Methods: 256 Women who were 20 to 24 weeks pregnant completed the clinician-administered YBOCS and Mini International Neuropsychiatric Interview (MINI) along with a series of self-report questionnaires including the Edinburgh Postnatal Depression Scale (EPDS), Perinatal Anxiety Screening Scale (PASS) and Obsessive-Compulsive Inventory-Revised (OCI-R).

Results: Internal consistency of the YBOCS was excellent, and there were strong inter-scale correlations between the YBOCS Total Score, YBOCS Obsessions and Compulsions Severity Scales. The YBOCS demonstrated good known-groups validity differentiating women with and without OCD. Convergent validity with the OCI-R was demonstrated while relations with divergent validity were more mixed.

Conclusion: The YBOCS possesses strong psychometric properties in pregnant women.

目的:尽管许多妇女在围产期经历了强迫症症状,但耶鲁-布朗强迫症量表(YBOCS)尚未在这一人群中进行心理测量学评估。本研究检验了孕妇YBOCS的内部一致性、收敛效度和发散效度,以及因子结构。方法:256名怀孕20 ~ 24周的孕妇完成了临床管理的YBOCS和Mini国际神经精神病学访谈(Mini),并完成了包括爱丁堡产后抑郁量表(EPDS)、围产期焦虑筛查量表(PASS)和强迫症量表(OCI-R)在内的一系列自我报告问卷。结果:YBOCS量表的内部一致性较好,且YBOCS总分、YBOCS强迫和强迫严重程度量表之间存在较强的量表间相关性。YBOCS在区分女性强迫症患者和非强迫症患者方面表现出良好的已知组效度。OCI-R具有收敛效度,而与发散效度的关系则较为复杂。结论:YBOCS在孕妇中具有较强的心理测量特性。
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引用次数: 0
Risk of congenital anomalies associated with psychotropic medications: a review of neonatal reports in the FDA adverse event reporting System (FAERS). 与精神药物相关的先天性异常风险:FDA不良事件报告系统(FAERS)新生儿报告综述
IF 3.2 3区 医学 Q2 PSYCHIATRY Pub Date : 2024-12-23 DOI: 10.1007/s00737-024-01540-3
Jingping Zheng, Zhenpo Zhang, Yankun Liang, Qimin Wu, Chufeng Din, Yuting Wang, Lin Ma, Ling Su
<p><strong>Purpose: </strong>This study investigates the potential association between commonly prescribed psychotropic medications, such as Atypical Antipsychotics (AAs), Selective Serotonin Reuptake Inhibitors (SSRIs), and Serotonin Norepinephrine Reuptake Inhibitors (SNRIs), and congenital anomalies in newborns. The analysis uses data from the Food and Drug Administration Adverse Event Reporting System (FAERS).</p><p><strong>Methods: </strong>Spontaneously reported cases of congenital anomalies in newborns (under 28 days old) were extracted from the FAERS database, covering January 2004 to June 2023. Four signal detection methods-Reporting Odds Ratio (ROR), Medicines and Healthcare products Regulatory Agency (MHRA), Bayesian Confidence Propagation Neural Network (BCPNN), and Multi-item Gamma Poisson Shrinker (MGPS)-were employed to identify signals associated with neonatal deformities caused by specific drugs, ensuring signal stability and reliability.</p><p><strong>Results: </strong>The FAERS database contains 21,605 reports involving neonates, with 6,208 cases reporting congenital anomalies. Of these, 6,164 cases (99.29%) attributed the adverse events to drugs. The top ten psychotropic drugs associated with neonatal congenital anomalies were venlafaxine, quetiapine, olanzapine, sertraline, citalopram, mirtazapine, duloxetine, paroxetine, aripiprazole, and fluoxetine. Different drug classes showed varying risks of congenital anomalies, with higher signal frequencies observed for cardiac, nervous system, respiratory-thoracic-mediastinal, and musculoskeletal-connective tissue disorders.</p><p><strong>Conclusions: </strong>Our study suggests that commonly used psychotropic drugs may increase the risk of congenital abnormalities in newborns, necessitating caution for pregnant women. Compared to other psychotropic drugs, the teratogenic effects of aripiprazole and fluoxetine are relatively minor.</p><p><strong>Article highlights: </strong>Overcoming the Limitations of Clinical Trials in Special Populations: Due to ethical considerations involving pregnant women and newborns, conducting clinical trials is often challenging. Real-world studies are currently one of the most important sources of evidence for evaluating the safety of medication use during pregnancy. Addressing Challenges in International Signal Detection: There is no established gold standard for signal detection, and different countries use varying methods. To minimize the impact of false-positive signals on the results, this study employs a combination of four different methods for signal mining. Advancing Beyond Small Retrospective Cohort Studies and Case Reports: Most current research on the safety of medication use during pregnancy relies on small retrospective cohort studies or case reports. Studies based on large pharmacovigilance databases overcome these limitations. This approach not only captures information on all drugs that may lead to congenital anomalies in newborns but a
目的:本研究探讨非典型抗精神病药(AAs)、选择性5 -羟色胺再摄取抑制剂(SSRIs)和5 -羟色胺去甲肾上腺素再摄取抑制剂(SNRIs)等常用精神药物与新生儿先天性异常之间的潜在关联。该分析使用了来自美国食品和药物管理局不良事件报告系统(FAERS)的数据。方法:从FAERS数据库中提取2004年1月至2023年6月期间自发报告的28天以下新生儿先天性异常病例。采用报告优势比(ROR)、药品和保健产品监管机构(MHRA)、贝叶斯置信传播神经网络(BCPNN)和多条目伽玛泊松收缩器(MGPS)四种信号检测方法识别特定药物引起的新生儿畸形相关信号,确保信号的稳定性和可靠性。结果:FAERS数据库包含21605例涉及新生儿的报告,其中6208例报告先天性异常。其中6164例(99.29%)将不良事件归因于药物。与新生儿先天性异常相关的前十大精神药物为文拉法辛、喹硫平、奥氮平、舍曲林、西酞普兰、米氮平、度洛西汀、帕罗西汀、阿立哌唑和氟西汀。不同的药物类别显示出不同的先天性异常风险,在心脏、神经系统、呼吸-胸-纵隔和肌肉-骨骼-结缔组织疾病中观察到更高的信号频率。结论:本研究提示,常用精神药物可能增加新生儿先天性异常的风险,孕妇应谨慎使用。与其他精神药物相比,阿立哌唑和氟西汀的致畸作用相对较小。文章重点:克服特殊人群临床试验的局限性:由于涉及孕妇和新生儿的伦理考虑,进行临床试验往往具有挑战性。现实世界的研究是目前评估怀孕期间用药安全性的最重要的证据来源之一。应对国际信号检测中的挑战:信号检测没有既定的黄金标准,不同的国家使用不同的方法。为了最大限度地减少假阳性信号对结果的影响,本研究采用了四种不同的信号挖掘方法的组合。超越小型回顾性队列研究和病例报告:目前大多数关于妊娠期间药物使用安全性的研究依赖于小型回顾性队列研究或病例报告。基于大型药物警戒数据库的研究克服了这些限制。这种方法不仅可以获取所有可能导致新生儿先天性异常的药物信息,还可以监测罕见但重要的安全性信息,为评估妊娠期间药物使用的安全性提供更全面的数据支持。
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引用次数: 0
Commentary on "Intimate partner violence among ever-married Afghan women: patterns, associations and attitudinal acceptance". 评论“阿富汗已婚妇女的亲密伴侣暴力:模式、联系和态度接受”。
IF 3.2 3区 医学 Q2 PSYCHIATRY Pub Date : 2024-12-21 DOI: 10.1007/s00737-024-01546-x
Yingyu Zhong
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引用次数: 0
A narrative review on emerging issues about war-related trauma in perinatal women: good practice for assessment, prevention, and treatment. 关于围产期妇女战争相关创伤新问题的叙述性回顾:评估、预防和治疗的良好做法。
IF 3.2 3区 医学 Q2 PSYCHIATRY Pub Date : 2024-12-06 DOI: 10.1007/s00737-024-01537-y
M F Rodriguez-Muñoz, M Chrzan-Dętkoś, A Uka, H S Garcia-López, R Bina, H N Le

Background: Wars, in addition to causing death and destruction, have a negative impact on mental health, especially on perinatal women. The literature has identified psychological trauma as one of the most prevalent mental health issues associated with wars, but few studies have summarized how to assess, prevent, or treat this problem in perinatal women. To address this gap, the purpose of this study is to provide a narrative review of the current state of assessment, prevention, and treatment interventions of trauma among perinatal women living in war conditions or displaced as a result of a war.

Method: A literature search was performed in different research databases (e.g., Medline, PsycInfo). The search terms include a combination of trauma and stressor-related disorders and focused on diagnosis, prevention, and treatment.

Results: Most of the results were related to post traumatic stress disorder (PTSD) more than acute stress disorder, although there are not many assessments, and interventions (prevention or treatment) dedicated specifically to perinatal women affected by war conditions.

Conclusion: Research in this area is still scarce. Recommendations for evidence-based practices in assessment and prevention and treatment interventions and future directions in research and clinical practice are provided.

Highlights: • The literature on trauma in perinatal women is sparse, and especially among perinatal women living in conditions of war. • This paper presents a narrative review of evidence-based assessment and treatment for perinatal women victims of war who experience trauma.

背景:战争除了造成死亡和破坏外,还对心理健康产生负面影响,特别是对围产期妇女。文献已经确定心理创伤是与战争相关的最普遍的心理健康问题之一,但很少有研究总结了如何评估、预防或治疗围产期妇女的这一问题。为了解决这一差距,本研究的目的是对生活在战争条件下或因战争而流离失所的围产期妇女的创伤评估、预防和治疗干预的现状进行叙述回顾。方法:在不同的研究数据库(如Medline, PsycInfo)中进行文献检索。搜索词包括创伤和压力相关疾病的组合,并侧重于诊断、预防和治疗。结果:大多数结果与创伤后应激障碍(PTSD)有关,而不是急性应激障碍,尽管没有很多评估和干预措施(预防或治疗)专门针对受战争条件影响的围产期妇女。结论:这方面的研究还比较少。提出了评估、预防和治疗干预措施的循证实践建议以及未来研究和临床实践的方向。•关于围产期妇女创伤的文献很少,尤其是生活在战争条件下的围产期妇女。•本文介绍了对经历创伤的围产期战争妇女受害者的循证评估和治疗的叙述审查。
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引用次数: 0
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Archives of Women's Mental Health
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