Archives of Women's Mental Health最新文献

{"title":"Antipsychotic drug use during pregnancy and neonatal outcomes: a systematic review and meta-analysis","authors":"Dervla Quinn,&nbsp;Michael Donnelly,&nbsp;Ciaran O’Neill","doi":"10.1007/s00737-025-01651-5","DOIUrl":"10.1007/s00737-025-01651-5","url":null,"abstract":"<div><h3>Purpose</h3><p>The use of antipsychotics during pregnancy has increased over the past two decades, primarily driven by an increase in the use of second-generation antipsychotic drugs. However, knowledge regarding the reproductive safety of antipsychotic drugs remains limited. This systematic review and meta-analysis investigated the associations between in utero antipsychotic drug exposure and congenital malformations and other neonatal outcomes.</p><h3>Methods</h3><p>A systematic search of MEDLINE, Embase, and PsycInfo was conducted from database inception to February 2024 for cohort and case-control (English language) studies that examined maternal antipsychotic exposure and reported risk estimates for one or more of the following outcomes: congenital malformation, preterm birth, low birth weight, stillbirth, or neonatal intensive care unit admission. Study quality was assessed using the Newcastle-Ottawa Scale, and reporting was guided by the PRISMA statement and MOOSE guidelines. Pooled estimates were calculated using a random-effects model.</p><h3>Results</h3><p>Twelve studies (comprising over 10 million pregnancies across 12 countries) met the inclusion criteria. A pooled meta-analysis of eight studies indicated borderline evidence of an association between the risk of congenital malformations and in utero antipsychotic drug exposure, with moderate heterogeneity (odds ratio [OR] 1.27; 95% confidence interval [CI] 0.996–1.624, <i>p</i> = 0.0535; I² = 53%). No association was observed when limited to second-generation antipsychotics (OR 1.16; 95% CI 0.78–1.72, <i>p</i> = 0.47). Regarding the outcome of preterm birth, antipsychotic exposure was associated with an increase in risk (OR 1.35; 95% CI 1.13–1.62, <i>p</i> &lt; 0.01), though there was moderate to high heterogeneity (I² = 70%). There was insufficient data to perform a meta-analysis for the other outcomes.</p><h3>Conclusion</h3><p>Meta-analyses did not indicate strong evidence that in utero antipsychotic exposure is a major teratogen; and although an association was observed between maternal antipsychotic use and preterm birth, there was significant heterogeneity across studies. The decision to continue antipsychotic use during pregnancy involves a complex balancing of risks and benefits for women and their healthcare professionals. Any potential risks to the developing foetus must be weighed against the risks of discontinuing treatment, including the possibility of relapse in women with severe mental illness, which can have serious consequences for a woman and her infant. Finally, there is a need for further robustly designed studies.</p></div>","PeriodicalId":8369,"journal":{"name":"Archives of Women's Mental Health","volume":"29 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00737-025-01651-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145930262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parental care in adolescence and women’s later postpartum psychosocial wellbeing: a 20-year prospective preconception cohort study","authors":"Stephanie R. Aarsman,&nbsp;S Ghazaleh Dashti,&nbsp;Genevieve Le Bas,&nbsp;Jacqui A. Macdonald,&nbsp;Christopher J. Greenwood,&nbsp;Delyse M. Hutchinson,&nbsp;Ebony J. Biden,&nbsp;Jessica A. Kerr,&nbsp;Tina Kretschmer,&nbsp;Lisa Ritland,&nbsp;Kimberly C. Thomson,&nbsp;Craig A. Olsson,&nbsp;Elizabeth A. Spry","doi":"10.1007/s00737-025-01641-7","DOIUrl":"10.1007/s00737-025-01641-7","url":null,"abstract":"<div><h3>Purpose</h3><p>Prior retrospective evidence links parental care when growing up to later mental health in the perinatal period, but prospective evidence on a broader range of perinatal outcomes is limited. This study aimed to estimate the effect of low parental care (maternal, paternal, or both) during adolescence on psychosocial wellbeing in women at one year postpartum.</p><h3>Methods</h3><p>We emulated a target trial using observational data from a preconception cohort study, the Victorian Intergenerational Health Cohort Study (<i>N</i> = 398 women, 609 infants). At age 16 years, adolescents reported on care from their parental figures. After becoming parents themselves, up to 20 years later, they were assessed at one year postpartum on psychosocial wellbeing outcomes (social support, partner coercive control, depressive symptoms, parenting anxiety, and parenting self-efficacy). Generalised estimating equations were used to estimate relative risks of each outcome by low parental care, adjusted for potential baseline confounders.</p><h3>Results</h3><p>Low parental care was associated with a number of aspects of women’s social and psychological wellbeing at one year postpartum. The strongest evidence was observed for low maternal care and high family social support (aRR = 0.84, 95%CI 0.72–0.97), high partner coercive control (aRR = 1.38, 95%CI 1.05–1.83), and high depressive symptoms (aRR = 2.03, 95%CI 1.07–3.86). For most outcomes, effect sizes for one low-care caregiver were similar to effect sizes for two low-care caregivers.</p><h3>Conclusions</h3><p>Women who report one or more primary caregiver relationships characterised by low care in adolescence may face increased risk for psychological difficulties within a context of fewer social supports after becoming parents.</p></div>","PeriodicalId":8369,"journal":{"name":"Archives of Women's Mental Health","volume":"29 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145930260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Which therapy works best for maternal depressive symptoms? A network meta-analysis of psychotherapeutic interventions","authors":"Hakan Öztürk,&nbsp;Rüveyda Yüksel,&nbsp;Ayça Balmumcu","doi":"10.1007/s00737-025-01658-y","DOIUrl":"10.1007/s00737-025-01658-y","url":null,"abstract":"<div><h3>Purpose</h3><p>Maternal depression is a significant public health concern that can adversely affect both mothers and their children. Although various psychotherapeutic interventions have been proposed, their relative comparative efficacy remains unclear. This network meta-analysis (NMA) aimed to evaluate and compare the efficacy of different psychotherapeutic interventions in reducing maternal depressive symptoms.</p><h3>Methods</h3><p>A systematic search was conducted in the Web of Science Core Collection (Science Citation Index Expanded and Social Sciences Citation Index) to identify randomized controlled trials (RCTs) published between 1 February 2021 and 1 February 2025. Eligible studies included mothers aged ≥ 18 years who were assessed for maternal depressive symptoms using the Edinburgh Postnatal Depression Scale (EPDS) and received any form of psychotherapy. Data were extracted using a predefined format (PROSPERO ID: CRD420251010916). Random-effects models were used to perform the NMA in R, reporting mean differences (MD) with 95% confidence intervals (CIs) and P-scores.</p><h3>Results</h3><p>A total of 8 RCTs involving 2,919 participants were included. Cognitive behavioral therapy (CBT) was the only intervention that showed a statistically significant reduction in depressive symptoms compared to treatment as usual (TAU) (MD = -3.22, 95%CI: -5.91 to -0.54; <i>p</i> = 0.019; P-score = 0.92). Other interventions showed trends toward improvement, but these were not statistically significant (<i>p</i> &gt; 0.05).</p><h3>Conclusion</h3><p>CBT emerged as the most efficacious psychotherapeutic approach in both direct and indirect comparisons, supported by statistical evidence from the NMA.</p></div>","PeriodicalId":8369,"journal":{"name":"Archives of Women's Mental Health","volume":"29 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00737-025-01658-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145930263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender and income disparities in World Psychiatry Congress participation (2023–2024)","authors":"Imran Gokcen Yilmaz-Karaman,&nbsp;Mariana Pinto da Costa,&nbsp;Betul Koseoglu,&nbsp;Asli Ugur Oktar,&nbsp;Florence Thibaut,&nbsp;Ann Færden","doi":"10.1007/s00737-025-01646-2","DOIUrl":"10.1007/s00737-025-01646-2","url":null,"abstract":"<div><h3>Purpose</h3><p>Although the number of women in psychiatry has increased substantially, gender disparities remain in leadership and visibility at scientific meetings. Country income level also affects academic participation, but its impact within the field of psychiatry remains underinvestigated. This study examined gender and income disparities at the country level, as well as gender and income disparities within countries, at two consecutive World Congresses of Psychiatry (WCPs), held in Austria (2023) and Mexico (2024).</p><h3>Methods</h3><p>The scientific programs of WCP 2023 and WCP 2024 were systematically reviewed to identify all speakers and chairs. Data were extracted on gender, role, session type, and country income level, classified according to World Bank criteria. Gender was determined from congress profiles, photographs, pronouns, or the Gender API. Statistical analyses included chi-square tests with Bonferroni corrections, with significance set at <i>p</i> &lt; 0.05.</p><h3>Results</h3><p>WCP 2023 featured 999 speakers/chairs, and WCP 2024 featured 574. Women’s representation increased significantly from 37.4% in 2023 to 43.4% in 2024 (<i>χ²</i> = 5.382, <i>df</i> = 1, <i>p</i> = 0.020). Participation from low- and middle-income countries also rose in 2024, while men’s representation from high-income countries declined. Several session types in 2024 reached or exceeded gender parity, including Distinguished Lectures (58.3%), Panel Discussions (50%), and Early Career Psychiatrist Sessions (60%).</p><h3>Conclusions</h3><p>Women’s representation at WCPs has shown encouraging improvement, although parity has not yet been achieved, and differences are evident by country income level. Hosting congresses in middle-income countries may support broader participation. Continued monitoring, mentorship initiatives, and inclusive conference policies can further strengthen gender equality and global representation in psychiatry.</p></div>","PeriodicalId":8369,"journal":{"name":"Archives of Women's Mental Health","volume":"29 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00737-025-01646-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145910262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitamin D levels and perinatal anxiety in an anxiety-focused behavioral intervention program in Pakistan","authors":"Semra Etyemez,&nbsp;Kruti Mehta,&nbsp;Jennifer Faiz,&nbsp;Mehrose Ahmad,&nbsp;Ahmed Zaidi,&nbsp;Najia Atif,&nbsp;Atif Rahman,&nbsp;Abid Malik,&nbsp;Kristin M. Voegtline,&nbsp;Pamela J. Surkan,&nbsp;Lauren M. Osborne","doi":"10.1007/s00737-025-01653-3","DOIUrl":"10.1007/s00737-025-01653-3","url":null,"abstract":"<div><h3>Purpose</h3><p>This study investigates Vitamin D levels across the perinatal period and relationships with perinatal anxiety and immune markers in women in Pakistan.</p><h3>Methods</h3><p>We analyzed plasma levels of 25-hydroxyvitamin D and cytokines and chemokines from 117 participants from the “Happy Mother-Healthy Baby” trial, which evaluated a non-specialist delivered cognitive behavioral therapy intervention for perinatal anxiety. Blood samples were collected at four timepoints: T1 (10–22 weeks), T2 (22–26 weeks), T3 (34–38 weeks), and T4 (six weeks postpartum). Participants were categorized into anxiety groups using K-means clustering. Mixed-effect models were used to examine Vitamin D trajectories, and moderation analysis explored the impact of immune markers on the Vitamin D-anxiety relationship.</p><h3>Results</h3><p>Vitamin D levels were severely deficient across all timepoints (&lt; 5 ng/ml) and declined significantly from T1 to T2 (β = -0.549, <i>p</i> = .006) before rebounding postpartum (β = 1.492, <i>p</i> &lt; .0001). Despite this widespread Vitamin D deficiency, no significant differences in Vitamin D trajectories were observed across anxiety groups. Higher innate immune activity correlated with higher Vitamin D levels at T1. IL-6 and CXCL-8 levels moderated the Vitamin D and anxiety relationship at T2 (IL-6: β = 2.98, <i>p</i> = .015; CXCL-8: β = 0.72, <i>p</i> = .030); among those with higher levels of IL-6 and CXCL-8, higher Vitamin D levels were associated with higher levels of anxiety.</p><h3>Conclusions</h3><p>These findings indicate the need for further research on maternal Vitamin D deficiency and its relationship with immune function in low- and middle-income countries.</p></div>","PeriodicalId":8369,"journal":{"name":"Archives of Women's Mental Health","volume":"29 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145910362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychological stress and functional ovarian suppression in women with PCOM: an observational study of FHA-like neuroendocrine phenotypes","authors":"Vanessa Silva,&nbsp;Sérgio Soares,&nbsp;Rui Miguelote","doi":"10.1007/s00737-025-01657-z","DOIUrl":"10.1007/s00737-025-01657-z","url":null,"abstract":"<div><h3>Propose</h3><p> To examine how chronic psychological stress alters gonadotropin dynamics and disrupts ovarian endocrine function in women with polycystic ovarian morphology (PCOM), and to discuss the modulatory role of leptin in this process.</p><h3>Methods</h3><p> In this cross-sectional study of 134 women, participants were classified into four groups: three subgroups of women with oligomenorrhea—PCOM with stress, PCOM without stress, and NON-PCOM/NON-STRESS—and a comparison group of eumenorrheic controls. Psychological stress was assessed with validated psychometric instruments (STAI, HADS, PSS-10), and a composite Stress Index was derived. PCOM was defined according to the 2023 International Evidence-based Guideline for PCOS. Stress status was classified using established cut-offs for each instrument, with non-stress cohorts defined by scores consistently below clinical thresholds. Hormonal profiling included LH, FSH, estradiol, AMH, leptin, cortisol, and ACTH. Mediation and moderation models were employed to examine the relationships among stress, leptin, the LH/FSH ratio, and ovarian endocrine markers, as AMH and estradiol.</p><h3>Results</h3><p> Women in the PCOM–STRESS group exhibited significantly lower LH levels, LH/FSH ratios, and AMH concentrations compared to PCOM–NON–STRESS, despite similar ovarian morphology and preserved FSH levels. Mediation analysis revealed that the LH/FSH ratio significantly mediated the effect of psychological stress on both estradiol and AMH levels. Moderation analysis indicated that leptin modulated the impact of stress on the LH/FSH ratio (interaction p = 0.004), with more pronounced suppressive effects of psychological stress under low leptin levels. Despite high psychological stress, women in the PCOM–STRESS group showed no activation of the HPA axis, suggesting neuroendocrine resilience or adaptation. These findings highlight the clinical value of assessing both psychological and metabolic context in women with ambiguous ovulatory dysfunction.</p><h3>Conclusion</h3><p> Chronic psychological stress in women with PCOM is associated with functional suppression of LH and ovarian endocrine output, reflecting an attenuation of the typical PCOS endocrine phenotype despite the polycystic ovarian morphology. Leptin modulates individual susceptibility to stress-induced reproductive suppression, acting as a potential permissive signal of hypothalamic resilience. Assessing gonadotropin ratios and metabolic context may improve diagnostic accuracy in women with ambiguous ovulatory dysfunction.</p></div>","PeriodicalId":8369,"journal":{"name":"Archives of Women's Mental Health","volume":"29 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00737-025-01657-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145910246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex/gender differences in autistic traits, intelligence and executive functions of school-aged autistic children without intellectual disability","authors":"Katarína Polónyiová,&nbsp;Peter Teličák,&nbsp;Klaudia Kyselicová,&nbsp;Dóra Dukonyová,&nbsp;Daniela Ostatníková","doi":"10.1007/s00737-025-01663-1","DOIUrl":"10.1007/s00737-025-01663-1","url":null,"abstract":"<div><h3>Background</h3><p>ASD has been more often diagnosed and researched in men than women, shaping diagnostic criteria which may not adequately capture the female presentation. Examining differences between girls and boys with ASD could enhance diagnostic accuracy and help reduce gender-related biases in research and clinical practice. The aim of this research was to analyze potential differences in autistic traits, intelligence, and executive functions of school-aged girls and boys diagnosed with ASD without intellectual disability.</p><h3>Methods</h3><p>The research sample consisted of 79 children with ASD, 20 girls and 59 boys, aged between 6 and 12 years. Autistic traits were measured by Autism Diagnostic Observation Schedule – Second Version and Autism Diagnostic Interview-Revised, intelligence by the Woodcock-Johnson International Editions II, and executive functions by Wisconsin Card Sorting Test and Behavior Rating Inventory of Executive Function 2.</p><h3>Results</h3><p>Girls scored lower in the amount of restricted, repetitive and stereotyped behaviors, but showed more severe deficits in Emotion Regulation, Cognitive Regulation and clinical scales Shift and Initiate, as measured by BRIEF-2.</p><h3>Conclusion</h3><p>Our results indicate girls with ASD exhibit certain differences from boys with ASD, which may be diagnostically relevant and helpful for their early detection and access to necessary resources and support. Nevertheless, extensive further research on the sex/gender differences and female ASD presentation is still needed.</p></div>","PeriodicalId":8369,"journal":{"name":"Archives of Women's Mental Health","volume":"29 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00737-025-01663-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145910323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postpartum retention in opioid agonist treatment for opioid dependence: A population-based cohort study","authors":"Joanna Zhou,&nbsp;Bianca Varney,&nbsp;Nicola Jones,&nbsp;Chrianna Bharat,&nbsp;Louisa Degenhardt,&nbsp;Alys Havard,&nbsp;Duong Thuy Tran","doi":"10.1007/s00737-025-01640-8","DOIUrl":"10.1007/s00737-025-01640-8","url":null,"abstract":"<div><h3>Purpose</h3><p>Opioid agonist treatment (OAT) is the first-line treatment for opioid dependence during pregnancy and recommended for at least one year postpartum or until a strong maternal-infant bond and stable family environment is established. Evidence on postpartum OAT retention is limited. We examined retention rates and associated maternal characteristics.</p><h3>Methods</h3><p>We linked OAT prescription authority to perinatal, mortality, and other data sources. We identified all opioid-dependent women who gave birth in New South Wales, Australia (1 January 2004-31 March 2020) while receiving OAT. We defined retention at 90, 180, and 365 days postpartum as continuous treatment over each period. We calculated retention rates and used generalised linear modelling to examine association between retention and maternal socio-demographic and clinical factors.</p><h3>Results</h3><p>There were 3933 childbirths among 2514 women on OAT. Retention rates were 93.3% (<i>n</i> = 3670) at 90 days, 88.4% (<i>n</i> = 3475) at 180 days, and 78.5% (<i>n</i> = 3086) at 365 days. Retention at 180 days was lower for those who gave birth after 2015, were Indigenous, had recent conviction or incarceration, initiated OAT after conception, received buprenorphine, or had a mental illness. We observed similar association patterns at 90 and 365 days.</p><h3>Conclusions</h3><p>Among women on OAT at childbirth, postpartum treatment retention was high but varied across subgroups. Lower retention among women who initiated OAT late in pregnancy or with social or clinical risk factors highlights the need for targeted support. Lower buprenorphine retention warrants ongoing monitoring and tailored care, particularly in settings where it is the preferred treatment during pregnancy.</p></div>","PeriodicalId":8369,"journal":{"name":"Archives of Women's Mental Health","volume":"29 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12769642/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145905567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex differences in the independent and combined effects of genomic and exposomic risks for schizophrenia on distressing psychotic experiences: insights from the ABCD study","authors":"Thanavadee Prachason,&nbsp;Angelo Arias-Magnasco,&nbsp;Bochao Danae Lin,&nbsp;Jim van Os,&nbsp;Bart P. F. Rutten,&nbsp;Lotta-Katrin Pries,&nbsp;Sinan Guloksuz","doi":"10.1007/s00737-025-01644-4","DOIUrl":"10.1007/s00737-025-01644-4","url":null,"abstract":"<div><h3>Purpose</h3><p>To investigate sex-dependent effects of polygenic risk (PRS-SCZ) and exposome score (ES-SCZ) for schizophrenia, both independently and jointly, on distressing psychotic experiences (PEs) in early adolescents.</p><h3>Method</h3><p>Baseline to 3-year follow-up data of the Adolescent Brain and Cognitive Development Study (ABCD) were used. PRS-SCZ and ES-SCZ were calculated to assess cumulative genetic and environmental (childhood adversity, cannabis use, hearing impairment, and winter births) risk for schizophrenia, respectively. The primary outcome was past-month distressing PEs at the 3-year follow-up. Secondary outcomes included distressing PEs across four yearly assessments: lifetime (≥ 1 wave), repeated (≥ 2 or ≥ 3 waves), and persisting (≥ 4 waves). Sex-stratified multilevel logistic regression models were used to test the independent and joint associations of binary modes (&gt; 75th percentile) of PRS-SCZ (PRS-SCZ₇₅) and ES-SCZ (ES-SCZ₇₅) on the outcomes. As sensitivity analysis, the sex-stratified analyses were repeated on a randomly selected unrelated sample, and the coefficients of males and females were compared.</p><h3>Results</h3><p>PRS-SCZ₇₅ was not associated with past-month distressing PEs in either sex but significantly associated with lifetime and repeated (≥ 2 waves) distressing PEs only in females. In both sexes, ES-SCZ₇₅ was significantly associated with all PE outcomes but did not additively interact with PRS-SCZ₇₅ in predicting them. Sensitivity analysis confirmed the findings and revealed a significant sex difference in the association between PRS-SCZ₇₅ and lifetime distressing PEs.</p><h3>Conclusion</h3><p>The influence of genomic risk for schizophrenia on distressing PEs might be sex-dependent, whereas that of the exposomic risk was universal in early adolescence. Further studies in larger samples are needed.</p></div>","PeriodicalId":8369,"journal":{"name":"Archives of Women's Mental Health","volume":"29 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00737-025-01644-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145910203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mental health service utilization in a novel insurance-based Ob/Gyn integrated model for women across the lifespan","authors":"Andréane Lavallée,&nbsp;Vanessa Babineau,&nbsp;Kristina D’Antonio,&nbsp;Elizabeth Werner,&nbsp;Andrew T. Drysdale,&nbsp;Madalyn Osbourne,&nbsp;Myrriam Grubb,&nbsp;Nathalie Moise,&nbsp;Inbal Reuveni,&nbsp;Zhijun Zhang,&nbsp;Seonjoo Lee,&nbsp;Dani Dumitriu,&nbsp;Mary D’Alton,&nbsp;Catherine Monk","doi":"10.1007/s00737-025-01652-4","DOIUrl":"10.1007/s00737-025-01652-4","url":null,"abstract":"<div><h3>Purpose</h3><p>Women’s Mental Health @Obstetrics and Gynecology (WMH @Ob/Gyn) is a novel, insurance-based clinical model integrated in Ob/Gyn practices that offers approachable, acceptable, available, and affordable mental healthcare to women across the lifespan. Women seen by Ob/Gyn physicians for physical healthcare needs are referred to the WMH @Ob/Gyn service based on patient request, provider observation, and/or results on universal depression screening. WMH@Ob/Gyn’ services include mental health screening, psychotherapy, psychopharmacology and support groups, all embedded into Ob/Gyn. Here, we sought to evaluate utilization rates of mental health services as an outcome of increased access resulting from real-world implementation of WMH @Ob/Gyn.</p><h3>Methods</h3><p>This prospective observational cohort study followed all patients referred to WMH @Ob/Gyn from 02/2020 to 12/2022. Data were obtained from a clinical registry and patient electronic health records. Utilization was estimated on initiation (proportion of women who attended at least one mental health visit), and sustainment (proportion of women who attended three or more visits). </p><h3>Results</h3><p>2,661 women were referred to WMH @Ob/Gyn; 65% initiated, out of which 36% sustained treatment. Hispanic/Latina/Spanish women were less likely to initiate treatment. Of those who initiated, women whose insurance was non-participating in mental healthcare, women that were not pregnant, and younger women, had lower odds of sustaining treatment. </p><h3>Conclusion</h3><p>WMH @Ob/Gyn facilitates the initiation and sustainment of mental health treatment at rates considerably higher than those observed in comparable perinatal-integrated programs or the general population. However, persistent systemic barriers, including disparities in physical and mental health insurance coverage, continue to constrain equitable, sustained access to mental healthcare. </p></div>","PeriodicalId":8369,"journal":{"name":"Archives of Women's Mental Health","volume":"29 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12765718/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145899114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}