Pub Date : 2025-01-15DOI: 10.1007/s00737-024-01551-0
Phyllis Ohene-Agyei, Greg D Gamble, Thach Tran, Jane E Harding, Caroline A Crowther
Purpose: There is limited high-quality evidence about perinatal mental health among women with gestational diabetes. We aimed to assess the risks and longitudinal changes in anxiety, depression, and health-related quality of life comparing women with gestational diabetes and those without among a contemporary cohort of pregnant women.
Methods: Prospective cohort study of participants in the GEMS Trial. Women with a singleton pregnancy were eligible if they had a 75-g diagnostic oral glucose-tolerance test between 24 and 32 weeks' gestation, provided written informed consent, and completed questionnaires about anxiety, depression, and health-related quality of life at the study time points.
Results: There were no differences in risk for anxiety (RR 1.13, 95% CI 0.86, 1.49; p = 0.39) or depression (RR 1.08, 95% CI 0.78, 1.50; p = 0.64) between the two groups at 36 weeks' gestation or 6 months postpartum [anxiety: (RR 1.21, 95% CI 0.90, 1.63; p = 0.21); depression: (RR 0.84, 95% CI 0.55, 1.28; p = 0.43]. However, at 36 weeks' gestation participants with gestational diabetes reported better physical functioning, and at 6 months postpartum, better mental functioning (mean difference (MD) in scores 1.28, 95% CI 0.25, 2.30; p = 0.01) although worse physical functioning (MD -2.99, 95% CI -3.90, -2.07; p = < 0.001) compared to participants without.
Conclusion: The risk for poor mental health during the perinatal period does not differ importantly among women diagnosed and treated for gestational diabetes compared to the general pregnant population.
目的:关于妊娠糖尿病妇女围产期心理健康的高质量证据有限。我们的目的是评估在当代孕妇队列中,比较妊娠期糖尿病妇女和无妊娠糖尿病妇女在焦虑、抑郁和健康相关生活质量方面的风险和纵向变化。方法:对GEMS试验参与者进行前瞻性队列研究。单胎妊娠妇女如果在妊娠24至32周期间进行75克诊断性口服葡萄糖耐量试验,提供书面知情同意,并在研究时间点完成关于焦虑、抑郁和健康相关生活质量的问卷调查,则符合条件。结果:两组患者焦虑风险无差异(RR 1.13, 95% CI 0.86, 1.49;p = 0.39)或抑郁(RR 1.08, 95% CI 0.78, 1.50;p = 0.64),两组在妊娠36周或产后6个月的焦虑差异(RR 1.21, 95% CI 0.90, 1.63;p = 0.21);抑郁:(RR 0.84, 95% CI 0.55, 1.28;p = 0.43]。然而,在妊娠36周时,患有妊娠糖尿病的参与者报告了更好的身体功能,在产后6个月时,报告了更好的心理功能(平均差异(MD)评分1.28,95% CI 0.25, 2.30;p = 0.01),但身体功能较差(MD -2.99, 95% CI -3.90, -2.07;p =结论:在诊断和治疗过妊娠糖尿病的妇女中,围产期心理健康状况不佳的风险与一般妊娠人群相比没有显著差异。
{"title":"Gestational diabetes and mental health: longitudinal analysis of data from the GEMS randomized trial.","authors":"Phyllis Ohene-Agyei, Greg D Gamble, Thach Tran, Jane E Harding, Caroline A Crowther","doi":"10.1007/s00737-024-01551-0","DOIUrl":"https://doi.org/10.1007/s00737-024-01551-0","url":null,"abstract":"<p><strong>Purpose: </strong>There is limited high-quality evidence about perinatal mental health among women with gestational diabetes. We aimed to assess the risks and longitudinal changes in anxiety, depression, and health-related quality of life comparing women with gestational diabetes and those without among a contemporary cohort of pregnant women.</p><p><strong>Methods: </strong>Prospective cohort study of participants in the GEMS Trial. Women with a singleton pregnancy were eligible if they had a 75-g diagnostic oral glucose-tolerance test between 24 and 32 weeks' gestation, provided written informed consent, and completed questionnaires about anxiety, depression, and health-related quality of life at the study time points.</p><p><strong>Results: </strong>There were no differences in risk for anxiety (RR 1.13, 95% CI 0.86, 1.49; p = 0.39) or depression (RR 1.08, 95% CI 0.78, 1.50; p = 0.64) between the two groups at 36 weeks' gestation or 6 months postpartum [anxiety: (RR 1.21, 95% CI 0.90, 1.63; p = 0.21); depression: (RR 0.84, 95% CI 0.55, 1.28; p = 0.43]. However, at 36 weeks' gestation participants with gestational diabetes reported better physical functioning, and at 6 months postpartum, better mental functioning (mean difference (MD) in scores 1.28, 95% CI 0.25, 2.30; p = 0.01) although worse physical functioning (MD -2.99, 95% CI -3.90, -2.07; p = < 0.001) compared to participants without.</p><p><strong>Conclusion: </strong>The risk for poor mental health during the perinatal period does not differ importantly among women diagnosed and treated for gestational diabetes compared to the general pregnant population.</p>","PeriodicalId":8369,"journal":{"name":"Archives of Women's Mental Health","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142982426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-10DOI: 10.1007/s00737-024-01553-y
Marie Mulvad Grønlund, Line Riis Jølving, Sören Möller, Rikke Wesselhoeft, Mette Bliddal
Purpose: Infertility is common and an increasing number of women go through medically assisted reproduction (fertility treatment) to achieve pregnancy. This may affect mental health. We examined if fertility treatment and the specific fertility treatment method used (in vivo or in vitro) were associated with impaired mental health during or after pregnancy.
Methods: Using self-reported data from the Odense Child Cohort, we assessed prenatal stress by the 10-item Cohen Perceived Stress Scale (PSS-10) during pregnancy at median gestational week 27 and postnatal depressive symptoms by the Edinburgh Postnatal Depression Scale (EPDS) at median postpartum week 15. We compared fertility-treated women overall and by fertility treatment method to women who conceived spontaneously. We conducted linear regression analyses to evaluate the PSS-10 score dimensionally and logistic regression to evaluate EPDS scores above cut-off (≥ 11).
Results: A total of 108 of 820 women (13%) gave birth after fertility treatment. Their prenatal mean stress (PSS-10) score was 11.38 compared to 11.78 for women who conceived spontaneously, leading to an adjusted mean difference of -0.09 points (95% confidence interval (CI): -1.88 to 1.69). In the fertility-treated group, 9.7% had EPDS scores ≥ 11 compared to 10.7% in the spontaneous conception group (adjusted odds ratio of 0.71 (95% CI: 0.26 to 1.91)). The MAR method (in vivo/vitro) did not influence these results.
Conclusion: Women who gave birth after fertility treatment did not report higher levels of prenatal stress or postpartum depressive symptoms than women who conceived spontaneously.
{"title":"Mental health during and after pregnancy in medically assisted reproduction: a danish cohort study.","authors":"Marie Mulvad Grønlund, Line Riis Jølving, Sören Möller, Rikke Wesselhoeft, Mette Bliddal","doi":"10.1007/s00737-024-01553-y","DOIUrl":"https://doi.org/10.1007/s00737-024-01553-y","url":null,"abstract":"<p><strong>Purpose: </strong>Infertility is common and an increasing number of women go through medically assisted reproduction (fertility treatment) to achieve pregnancy. This may affect mental health. We examined if fertility treatment and the specific fertility treatment method used (in vivo or in vitro) were associated with impaired mental health during or after pregnancy.</p><p><strong>Methods: </strong>Using self-reported data from the Odense Child Cohort, we assessed prenatal stress by the 10-item Cohen Perceived Stress Scale (PSS-10) during pregnancy at median gestational week 27 and postnatal depressive symptoms by the Edinburgh Postnatal Depression Scale (EPDS) at median postpartum week 15. We compared fertility-treated women overall and by fertility treatment method to women who conceived spontaneously. We conducted linear regression analyses to evaluate the PSS-10 score dimensionally and logistic regression to evaluate EPDS scores above cut-off (≥ 11).</p><p><strong>Results: </strong>A total of 108 of 820 women (13%) gave birth after fertility treatment. Their prenatal mean stress (PSS-10) score was 11.38 compared to 11.78 for women who conceived spontaneously, leading to an adjusted mean difference of -0.09 points (95% confidence interval (CI): -1.88 to 1.69). In the fertility-treated group, 9.7% had EPDS scores ≥ 11 compared to 10.7% in the spontaneous conception group (adjusted odds ratio of 0.71 (95% CI: 0.26 to 1.91)). The MAR method (in vivo/vitro) did not influence these results.</p><p><strong>Conclusion: </strong>Women who gave birth after fertility treatment did not report higher levels of prenatal stress or postpartum depressive symptoms than women who conceived spontaneously.</p>","PeriodicalId":8369,"journal":{"name":"Archives of Women's Mental Health","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142943406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-07DOI: 10.1007/s00737-024-01547-w
Xianjie Peng, Ruwei Nie, Sihan Tong
Purpose: The purpose of this study is to investigate the impact of the employment situation on the anxiety levels and research self-efficacy of graduate students, with a particular focus on female graduate students. The study aims to understand how the use of AIGC tools, which has become more frequent among those with lower research self-efficacy, affects anxiety and research resilience. Additionally, the research explores the role of the mentoring relationship in influencing the psychological and academic experiences of female graduate students.
Method: The research involved 1164 female master's and doctoral students and employed a moderated chain mediation model. This model was constructed based on social cognitive theory and Habermas interaction theory to analyze the relationships between research self-efficacy, mobile phone dependence, anxiety, and research resilience. Data was collected and empirically analyzed using SPSS 26.0, a statistical software, to examine the proposed relationships and the moderating effect of the mentoring relationship.
Result: The findings revealed that scientific research self-efficacy positively influences research resilience among female graduate students. Additionally, mobile phone dependence and anxiety were found to play a chain mediating role between self-efficacy and research resilience. The study also discovered that the mentoring relationship negatively moderated the effects of mobile phone dependence and anxiety on these students.
Conclusion: Based on the results, the study concludes that mentors and academic administrators should consider the research capabilities and interests of students when assigning research tasks. It is recommended to establish a flight instructor mentorship system that maximizes the strengths of each mentor to support students, especially those with suboptimal mentor-mentee relationships. This approach could help in providing positive guidance and improving the research resilience of female graduate students who are more susceptible to anxiety and mobile phone dependence.
{"title":"Research on the self-efficacy and resilience of female graduate students in the era of artificial intelligence: analysis of the mechanism of mobile phone dependence, anxiety and mentoring relationship.","authors":"Xianjie Peng, Ruwei Nie, Sihan Tong","doi":"10.1007/s00737-024-01547-w","DOIUrl":"10.1007/s00737-024-01547-w","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of this study is to investigate the impact of the employment situation on the anxiety levels and research self-efficacy of graduate students, with a particular focus on female graduate students. The study aims to understand how the use of AIGC tools, which has become more frequent among those with lower research self-efficacy, affects anxiety and research resilience. Additionally, the research explores the role of the mentoring relationship in influencing the psychological and academic experiences of female graduate students.</p><p><strong>Method: </strong>The research involved 1164 female master's and doctoral students and employed a moderated chain mediation model. This model was constructed based on social cognitive theory and Habermas interaction theory to analyze the relationships between research self-efficacy, mobile phone dependence, anxiety, and research resilience. Data was collected and empirically analyzed using SPSS 26.0, a statistical software, to examine the proposed relationships and the moderating effect of the mentoring relationship.</p><p><strong>Result: </strong>The findings revealed that scientific research self-efficacy positively influences research resilience among female graduate students. Additionally, mobile phone dependence and anxiety were found to play a chain mediating role between self-efficacy and research resilience. The study also discovered that the mentoring relationship negatively moderated the effects of mobile phone dependence and anxiety on these students.</p><p><strong>Conclusion: </strong>Based on the results, the study concludes that mentors and academic administrators should consider the research capabilities and interests of students when assigning research tasks. It is recommended to establish a flight instructor mentorship system that maximizes the strengths of each mentor to support students, especially those with suboptimal mentor-mentee relationships. This approach could help in providing positive guidance and improving the research resilience of female graduate students who are more susceptible to anxiety and mobile phone dependence.</p>","PeriodicalId":8369,"journal":{"name":"Archives of Women's Mental Health","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143021647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-06DOI: 10.1007/s00737-024-01550-1
Laura Lærkegård Støve, Ruth Kirk Ertmann, Volkert Dirk Siersma, Sarah Strøyer de Voss, Johanne Smith-Nielsen
Purpose: This study investigated whether maternal antenatal attachment (MAA) in the third trimester was associated with self-reported problematic infant crying at eight weeks postnatally and explored links with postnatal depressive symptoms.
Methods: A prospective cohort study was conducted with 1287 pregnant participants in Danish general practice. MAA was measured using the Maternal Antenatal Attachment Scale (MAAS) in the third trimester. Both postnatal depressive symptoms and infant crying problems were assessed eight weeks postnatally, using the Edinburgh Postnatal Depression Scale (EPDS) and maternal reports, respectively.
Results: Low MAAS quality scores in the third trimester were initially associated with a 51% increased risk of reporting problematic infant crying at eight weeks, but this effect disappeared after adjusting for physical and mental health variables (e.g., chronic disease, anxiety, and depression symptoms) during pregnancy. No significant effects were found for MAAS intensity or total score. Low MAAS quality and overall MAAS scores were associated with an increased risk of scoring above cutoff on the EPDS. High levels of postnatal depressive symptoms at eight weeks significantly increased the likelihood of reporting problematic infant crying. Low MAAS scores combined with high levels of postnatal depressive symptoms did not increase the risk of problematic infant crying compared to low levels of depressive symptoms with low MAAS scores.
Conclusions: Our findings highlight the importance of considering maternal mental health when parents report infant crying problems postnatally. Furthermore, our results demonstrate that poor MAA in pregnancy is not necessarily linked with parental report of problematic infant crying after birth.
{"title":"Links among maternal antenatal attachment, postnatal depressive symptoms and infant crying: a prospective cohort study.","authors":"Laura Lærkegård Støve, Ruth Kirk Ertmann, Volkert Dirk Siersma, Sarah Strøyer de Voss, Johanne Smith-Nielsen","doi":"10.1007/s00737-024-01550-1","DOIUrl":"https://doi.org/10.1007/s00737-024-01550-1","url":null,"abstract":"<p><strong>Purpose: </strong>This study investigated whether maternal antenatal attachment (MAA) in the third trimester was associated with self-reported problematic infant crying at eight weeks postnatally and explored links with postnatal depressive symptoms.</p><p><strong>Methods: </strong>A prospective cohort study was conducted with 1287 pregnant participants in Danish general practice. MAA was measured using the Maternal Antenatal Attachment Scale (MAAS) in the third trimester. Both postnatal depressive symptoms and infant crying problems were assessed eight weeks postnatally, using the Edinburgh Postnatal Depression Scale (EPDS) and maternal reports, respectively.</p><p><strong>Results: </strong>Low MAAS quality scores in the third trimester were initially associated with a 51% increased risk of reporting problematic infant crying at eight weeks, but this effect disappeared after adjusting for physical and mental health variables (e.g., chronic disease, anxiety, and depression symptoms) during pregnancy. No significant effects were found for MAAS intensity or total score. Low MAAS quality and overall MAAS scores were associated with an increased risk of scoring above cutoff on the EPDS. High levels of postnatal depressive symptoms at eight weeks significantly increased the likelihood of reporting problematic infant crying. Low MAAS scores combined with high levels of postnatal depressive symptoms did not increase the risk of problematic infant crying compared to low levels of depressive symptoms with low MAAS scores.</p><p><strong>Conclusions: </strong>Our findings highlight the importance of considering maternal mental health when parents report infant crying problems postnatally. Furthermore, our results demonstrate that poor MAA in pregnancy is not necessarily linked with parental report of problematic infant crying after birth.</p>","PeriodicalId":8369,"journal":{"name":"Archives of Women's Mental Health","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142930487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-02DOI: 10.1007/s00737-024-01548-9
Catherine E Rast, Rashelle Musci, Jonathan S Abramowitz, Gerald Nestadt, Mary C Kimmel, Tracey Dibbs, Lauren M Osborne, Jack Samuels, Janice Krasnow, Eric A Storch
Purpose: Although many women experience obsessive-compulsive symptoms during the perinatal period, the Yale-Brown Obsessive Compulsive Scale (YBOCS) has not yet been psychometrically evaluated in this population. This study examined the internal consistency, convergent and divergent validity, and factor structure of the YBOCS among pregnant women.
Methods: 256 Women who were 20 to 24 weeks pregnant completed the clinician-administered YBOCS and Mini International Neuropsychiatric Interview (MINI) along with a series of self-report questionnaires including the Edinburgh Postnatal Depression Scale (EPDS), Perinatal Anxiety Screening Scale (PASS) and Obsessive-Compulsive Inventory-Revised (OCI-R).
Results: Internal consistency of the YBOCS was excellent, and there were strong inter-scale correlations between the YBOCS Total Score, YBOCS Obsessions and Compulsions Severity Scales. The YBOCS demonstrated good known-groups validity differentiating women with and without OCD. Convergent validity with the OCI-R was demonstrated while relations with divergent validity were more mixed.
Conclusion: The YBOCS possesses strong psychometric properties in pregnant women.
{"title":"Psychometric evaluation of the Yale-Brown Obsessive-Compulsive Scale in pregnant women.","authors":"Catherine E Rast, Rashelle Musci, Jonathan S Abramowitz, Gerald Nestadt, Mary C Kimmel, Tracey Dibbs, Lauren M Osborne, Jack Samuels, Janice Krasnow, Eric A Storch","doi":"10.1007/s00737-024-01548-9","DOIUrl":"https://doi.org/10.1007/s00737-024-01548-9","url":null,"abstract":"<p><strong>Purpose: </strong>Although many women experience obsessive-compulsive symptoms during the perinatal period, the Yale-Brown Obsessive Compulsive Scale (YBOCS) has not yet been psychometrically evaluated in this population. This study examined the internal consistency, convergent and divergent validity, and factor structure of the YBOCS among pregnant women.</p><p><strong>Methods: </strong>256 Women who were 20 to 24 weeks pregnant completed the clinician-administered YBOCS and Mini International Neuropsychiatric Interview (MINI) along with a series of self-report questionnaires including the Edinburgh Postnatal Depression Scale (EPDS), Perinatal Anxiety Screening Scale (PASS) and Obsessive-Compulsive Inventory-Revised (OCI-R).</p><p><strong>Results: </strong>Internal consistency of the YBOCS was excellent, and there were strong inter-scale correlations between the YBOCS Total Score, YBOCS Obsessions and Compulsions Severity Scales. The YBOCS demonstrated good known-groups validity differentiating women with and without OCD. Convergent validity with the OCI-R was demonstrated while relations with divergent validity were more mixed.</p><p><strong>Conclusion: </strong>The YBOCS possesses strong psychometric properties in pregnant women.</p>","PeriodicalId":8369,"journal":{"name":"Archives of Women's Mental Health","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142913758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-23DOI: 10.1007/s00737-024-01540-3
Jingping Zheng, Zhenpo Zhang, Yankun Liang, Qimin Wu, Chufeng Din, Yuting Wang, Lin Ma, Ling Su
<p><strong>Purpose: </strong>This study investigates the potential association between commonly prescribed psychotropic medications, such as Atypical Antipsychotics (AAs), Selective Serotonin Reuptake Inhibitors (SSRIs), and Serotonin Norepinephrine Reuptake Inhibitors (SNRIs), and congenital anomalies in newborns. The analysis uses data from the Food and Drug Administration Adverse Event Reporting System (FAERS).</p><p><strong>Methods: </strong>Spontaneously reported cases of congenital anomalies in newborns (under 28 days old) were extracted from the FAERS database, covering January 2004 to June 2023. Four signal detection methods-Reporting Odds Ratio (ROR), Medicines and Healthcare products Regulatory Agency (MHRA), Bayesian Confidence Propagation Neural Network (BCPNN), and Multi-item Gamma Poisson Shrinker (MGPS)-were employed to identify signals associated with neonatal deformities caused by specific drugs, ensuring signal stability and reliability.</p><p><strong>Results: </strong>The FAERS database contains 21,605 reports involving neonates, with 6,208 cases reporting congenital anomalies. Of these, 6,164 cases (99.29%) attributed the adverse events to drugs. The top ten psychotropic drugs associated with neonatal congenital anomalies were venlafaxine, quetiapine, olanzapine, sertraline, citalopram, mirtazapine, duloxetine, paroxetine, aripiprazole, and fluoxetine. Different drug classes showed varying risks of congenital anomalies, with higher signal frequencies observed for cardiac, nervous system, respiratory-thoracic-mediastinal, and musculoskeletal-connective tissue disorders.</p><p><strong>Conclusions: </strong>Our study suggests that commonly used psychotropic drugs may increase the risk of congenital abnormalities in newborns, necessitating caution for pregnant women. Compared to other psychotropic drugs, the teratogenic effects of aripiprazole and fluoxetine are relatively minor.</p><p><strong>Article highlights: </strong>Overcoming the Limitations of Clinical Trials in Special Populations: Due to ethical considerations involving pregnant women and newborns, conducting clinical trials is often challenging. Real-world studies are currently one of the most important sources of evidence for evaluating the safety of medication use during pregnancy. Addressing Challenges in International Signal Detection: There is no established gold standard for signal detection, and different countries use varying methods. To minimize the impact of false-positive signals on the results, this study employs a combination of four different methods for signal mining. Advancing Beyond Small Retrospective Cohort Studies and Case Reports: Most current research on the safety of medication use during pregnancy relies on small retrospective cohort studies or case reports. Studies based on large pharmacovigilance databases overcome these limitations. This approach not only captures information on all drugs that may lead to congenital anomalies in newborns but a
{"title":"Risk of congenital anomalies associated with psychotropic medications: a review of neonatal reports in the FDA adverse event reporting System (FAERS).","authors":"Jingping Zheng, Zhenpo Zhang, Yankun Liang, Qimin Wu, Chufeng Din, Yuting Wang, Lin Ma, Ling Su","doi":"10.1007/s00737-024-01540-3","DOIUrl":"https://doi.org/10.1007/s00737-024-01540-3","url":null,"abstract":"<p><strong>Purpose: </strong>This study investigates the potential association between commonly prescribed psychotropic medications, such as Atypical Antipsychotics (AAs), Selective Serotonin Reuptake Inhibitors (SSRIs), and Serotonin Norepinephrine Reuptake Inhibitors (SNRIs), and congenital anomalies in newborns. The analysis uses data from the Food and Drug Administration Adverse Event Reporting System (FAERS).</p><p><strong>Methods: </strong>Spontaneously reported cases of congenital anomalies in newborns (under 28 days old) were extracted from the FAERS database, covering January 2004 to June 2023. Four signal detection methods-Reporting Odds Ratio (ROR), Medicines and Healthcare products Regulatory Agency (MHRA), Bayesian Confidence Propagation Neural Network (BCPNN), and Multi-item Gamma Poisson Shrinker (MGPS)-were employed to identify signals associated with neonatal deformities caused by specific drugs, ensuring signal stability and reliability.</p><p><strong>Results: </strong>The FAERS database contains 21,605 reports involving neonates, with 6,208 cases reporting congenital anomalies. Of these, 6,164 cases (99.29%) attributed the adverse events to drugs. The top ten psychotropic drugs associated with neonatal congenital anomalies were venlafaxine, quetiapine, olanzapine, sertraline, citalopram, mirtazapine, duloxetine, paroxetine, aripiprazole, and fluoxetine. Different drug classes showed varying risks of congenital anomalies, with higher signal frequencies observed for cardiac, nervous system, respiratory-thoracic-mediastinal, and musculoskeletal-connective tissue disorders.</p><p><strong>Conclusions: </strong>Our study suggests that commonly used psychotropic drugs may increase the risk of congenital abnormalities in newborns, necessitating caution for pregnant women. Compared to other psychotropic drugs, the teratogenic effects of aripiprazole and fluoxetine are relatively minor.</p><p><strong>Article highlights: </strong>Overcoming the Limitations of Clinical Trials in Special Populations: Due to ethical considerations involving pregnant women and newborns, conducting clinical trials is often challenging. Real-world studies are currently one of the most important sources of evidence for evaluating the safety of medication use during pregnancy. Addressing Challenges in International Signal Detection: There is no established gold standard for signal detection, and different countries use varying methods. To minimize the impact of false-positive signals on the results, this study employs a combination of four different methods for signal mining. Advancing Beyond Small Retrospective Cohort Studies and Case Reports: Most current research on the safety of medication use during pregnancy relies on small retrospective cohort studies or case reports. Studies based on large pharmacovigilance databases overcome these limitations. This approach not only captures information on all drugs that may lead to congenital anomalies in newborns but a","PeriodicalId":8369,"journal":{"name":"Archives of Women's Mental Health","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142875973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-06DOI: 10.1007/s00737-024-01537-y
M F Rodriguez-Muñoz, M Chrzan-Dętkoś, A Uka, H S Garcia-López, R Bina, H N Le
Background: Wars, in addition to causing death and destruction, have a negative impact on mental health, especially on perinatal women. The literature has identified psychological trauma as one of the most prevalent mental health issues associated with wars, but few studies have summarized how to assess, prevent, or treat this problem in perinatal women. To address this gap, the purpose of this study is to provide a narrative review of the current state of assessment, prevention, and treatment interventions of trauma among perinatal women living in war conditions or displaced as a result of a war.
Method: A literature search was performed in different research databases (e.g., Medline, PsycInfo). The search terms include a combination of trauma and stressor-related disorders and focused on diagnosis, prevention, and treatment.
Results: Most of the results were related to post traumatic stress disorder (PTSD) more than acute stress disorder, although there are not many assessments, and interventions (prevention or treatment) dedicated specifically to perinatal women affected by war conditions.
Conclusion: Research in this area is still scarce. Recommendations for evidence-based practices in assessment and prevention and treatment interventions and future directions in research and clinical practice are provided.
Highlights: • The literature on trauma in perinatal women is sparse, and especially among perinatal women living in conditions of war. • This paper presents a narrative review of evidence-based assessment and treatment for perinatal women victims of war who experience trauma.
{"title":"A narrative review on emerging issues about war-related trauma in perinatal women: good practice for assessment, prevention, and treatment.","authors":"M F Rodriguez-Muñoz, M Chrzan-Dętkoś, A Uka, H S Garcia-López, R Bina, H N Le","doi":"10.1007/s00737-024-01537-y","DOIUrl":"https://doi.org/10.1007/s00737-024-01537-y","url":null,"abstract":"<p><strong>Background: </strong>Wars, in addition to causing death and destruction, have a negative impact on mental health, especially on perinatal women. The literature has identified psychological trauma as one of the most prevalent mental health issues associated with wars, but few studies have summarized how to assess, prevent, or treat this problem in perinatal women. To address this gap, the purpose of this study is to provide a narrative review of the current state of assessment, prevention, and treatment interventions of trauma among perinatal women living in war conditions or displaced as a result of a war.</p><p><strong>Method: </strong>A literature search was performed in different research databases (e.g., Medline, PsycInfo). The search terms include a combination of trauma and stressor-related disorders and focused on diagnosis, prevention, and treatment.</p><p><strong>Results: </strong>Most of the results were related to post traumatic stress disorder (PTSD) more than acute stress disorder, although there are not many assessments, and interventions (prevention or treatment) dedicated specifically to perinatal women affected by war conditions.</p><p><strong>Conclusion: </strong>Research in this area is still scarce. Recommendations for evidence-based practices in assessment and prevention and treatment interventions and future directions in research and clinical practice are provided.</p><p><strong>Highlights: </strong>• The literature on trauma in perinatal women is sparse, and especially among perinatal women living in conditions of war. • This paper presents a narrative review of evidence-based assessment and treatment for perinatal women victims of war who experience trauma.</p>","PeriodicalId":8369,"journal":{"name":"Archives of Women's Mental Health","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142784044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-06DOI: 10.1007/s00737-024-01538-x
Magdalena Babiszewska-Aksamit, Agnieszka Bzikowska-Jura, Anna Kotlińska, Agata Aduła, Agnieszka Chrobak, Justyna Domosud, Izabela Drążkowska, Paulina Gaweł, Artur Jakimiuk, Józefa Kołodziej, Barbara Królak-Olejnik, Katarzyna Lisak-Gurba, Katarzyna Mozdyniewicz, Aleksandra Mołas, Agnieszka Piątkowska, Elena Sinkiewicz-Darol, Aleksandra Wesołowska
Purpose: The study presents a cross-sectional analysis of the population of Ukrainian women who received maternity care in 11 Polish hospitals.
Methods: Multidirectional lactation counseling was implemented from March to November 2023 by the Human Milk Bank Foundation in cooperation with UNICEF Refugee Response Office in Poland. Medical data were collected using questionnaires prepared for the study. When the mother indicated that she had mental problems or the health care personnel spotted problems, she was she referred to a psychologist for diagnostics, who used questionnaires appropriate to the patient's situation such as: Patient Health Questionnaire-9 for depression assessment and Generalized Anxiety Disorder Questionnaire-7 for anxiety assessment.
Results: In total, 1203 consultations were carried out, of which 542 were lactation counseling, 305 - were physiotherapy, 227 - were psychological, and 129 - were with speech-language pathologists. Two hours of skin-to-skin contact (SSC) and latching on the breast within the 1st hour postpartum occurred in more than half of the participants. In the rest of the population, shortened or lack of SSC was associated with breastfeeding delayed by at least one day. 53% of the population required lactation counseling, of which 242 were one-time visits. Continued support was 98% effective in achieving breastfeeding goals. 167 mothers required psychological support, of which only 53 women continued treatment beyond one-time counseling. Only about 1% of women experienced mental disorders based on a psychological interview.
Conclusion: The use of lactation counseling more often than psychological counseling by refugee mothers could be related to the beneficial effects of breastfeeding on maternal well-being through hormonal self-regulation and empowerment as a mother. However, focused research is needed on the impact of breastfeeding on the mental health of refugee women.
{"title":"Good practice in lactation counseling for Ukrainian refugee mothers to ensure the health and mental benefits of breastfeeding - an observational study.","authors":"Magdalena Babiszewska-Aksamit, Agnieszka Bzikowska-Jura, Anna Kotlińska, Agata Aduła, Agnieszka Chrobak, Justyna Domosud, Izabela Drążkowska, Paulina Gaweł, Artur Jakimiuk, Józefa Kołodziej, Barbara Królak-Olejnik, Katarzyna Lisak-Gurba, Katarzyna Mozdyniewicz, Aleksandra Mołas, Agnieszka Piątkowska, Elena Sinkiewicz-Darol, Aleksandra Wesołowska","doi":"10.1007/s00737-024-01538-x","DOIUrl":"https://doi.org/10.1007/s00737-024-01538-x","url":null,"abstract":"<p><strong>Purpose: </strong>The study presents a cross-sectional analysis of the population of Ukrainian women who received maternity care in 11 Polish hospitals.</p><p><strong>Methods: </strong>Multidirectional lactation counseling was implemented from March to November 2023 by the Human Milk Bank Foundation in cooperation with UNICEF Refugee Response Office in Poland. Medical data were collected using questionnaires prepared for the study. When the mother indicated that she had mental problems or the health care personnel spotted problems, she was she referred to a psychologist for diagnostics, who used questionnaires appropriate to the patient's situation such as: Patient Health Questionnaire-9 for depression assessment and Generalized Anxiety Disorder Questionnaire-7 for anxiety assessment.</p><p><strong>Results: </strong>In total, 1203 consultations were carried out, of which 542 were lactation counseling, 305 - were physiotherapy, 227 - were psychological, and 129 - were with speech-language pathologists. Two hours of skin-to-skin contact (SSC) and latching on the breast within the 1st hour postpartum occurred in more than half of the participants. In the rest of the population, shortened or lack of SSC was associated with breastfeeding delayed by at least one day. 53% of the population required lactation counseling, of which 242 were one-time visits. Continued support was 98% effective in achieving breastfeeding goals. 167 mothers required psychological support, of which only 53 women continued treatment beyond one-time counseling. Only about 1% of women experienced mental disorders based on a psychological interview.</p><p><strong>Conclusion: </strong>The use of lactation counseling more often than psychological counseling by refugee mothers could be related to the beneficial effects of breastfeeding on maternal well-being through hormonal self-regulation and empowerment as a mother. However, focused research is needed on the impact of breastfeeding on the mental health of refugee women.</p>","PeriodicalId":8369,"journal":{"name":"Archives of Women's Mental Health","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142784051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}