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Psychological stress and functional ovarian suppression in women with PCOM: an observational study of FHA-like neuroendocrine phenotypes PCOM患者的心理压力和功能性卵巢抑制:fha样神经内分泌表型的观察性研究
IF 2.7 3区 医学 Q2 PSYCHIATRY Pub Date : 2026-01-07 DOI: 10.1007/s00737-025-01657-z
Vanessa Silva, Sérgio Soares, Rui Miguelote

Propose

To examine how chronic psychological stress alters gonadotropin dynamics and disrupts ovarian endocrine function in women with polycystic ovarian morphology (PCOM), and to discuss the modulatory role of leptin in this process.

Methods

In this cross-sectional study of 134 women, participants were classified into four groups: three subgroups of women with oligomenorrhea—PCOM with stress, PCOM without stress, and NON-PCOM/NON-STRESS—and a comparison group of eumenorrheic controls. Psychological stress was assessed with validated psychometric instruments (STAI, HADS, PSS-10), and a composite Stress Index was derived. PCOM was defined according to the 2023 International Evidence-based Guideline for PCOS. Stress status was classified using established cut-offs for each instrument, with non-stress cohorts defined by scores consistently below clinical thresholds. Hormonal profiling included LH, FSH, estradiol, AMH, leptin, cortisol, and ACTH. Mediation and moderation models were employed to examine the relationships among stress, leptin, the LH/FSH ratio, and ovarian endocrine markers, as AMH and estradiol.

Results

Women in the PCOM–STRESS group exhibited significantly lower LH levels, LH/FSH ratios, and AMH concentrations compared to PCOM–NON–STRESS, despite similar ovarian morphology and preserved FSH levels. Mediation analysis revealed that the LH/FSH ratio significantly mediated the effect of psychological stress on both estradiol and AMH levels. Moderation analysis indicated that leptin modulated the impact of stress on the LH/FSH ratio (interaction p = 0.004), with more pronounced suppressive effects of psychological stress under low leptin levels. Despite high psychological stress, women in the PCOM–STRESS group showed no activation of the HPA axis, suggesting neuroendocrine resilience or adaptation. These findings highlight the clinical value of assessing both psychological and metabolic context in women with ambiguous ovulatory dysfunction.

Conclusion

Chronic psychological stress in women with PCOM is associated with functional suppression of LH and ovarian endocrine output, reflecting an attenuation of the typical PCOS endocrine phenotype despite the polycystic ovarian morphology. Leptin modulates individual susceptibility to stress-induced reproductive suppression, acting as a potential permissive signal of hypothalamic resilience. Assessing gonadotropin ratios and metabolic context may improve diagnostic accuracy in women with ambiguous ovulatory dysfunction.

建议:探讨慢性心理应激如何改变多囊卵巢形态学(PCOM)女性的促性腺激素动态和卵巢内分泌功能,并探讨瘦素在这一过程中的调节作用。方法:在这项134名女性的横断面研究中,参与者被分为四组:少经妇女的三个亚组-有压力的PCOM,无压力的PCOM,非PCOM/无压力,以及一个痛经对照组。采用经验证的心理测量工具(STAI、HADS、PSS-10)评估心理压力,并得出综合应激指数。PCOM是根据PCOS的2023国际循证指南定义的。使用每种工具的既定截止值对应激状态进行分类,通过分数始终低于临床阈值来定义非应激队列。激素分析包括LH、FSH、雌二醇、AMH、瘦素、皮质醇和ACTH。采用中介和调节模型检验应激、瘦素、LH/FSH比值和卵巢内分泌指标(如AMH和雌二醇)之间的关系。结果:与pcom -非应激组相比,pcom -应激组的女性表现出明显较低的LH水平、LH/FSH比率和AMH浓度,尽管卵巢形态相似,FSH水平保持不变。中介分析显示,LH/FSH比值显著介导了心理应激对雌二醇和AMH水平的影响。调节分析表明,瘦素调节应激对LH/FSH比值的影响(相互作用p = 0.004),低瘦素水平下心理应激的抑制作用更为明显。尽管有很高的心理压力,PCOM-STRESS组的女性没有表现出HPA轴的激活,这表明神经内分泌有弹性或适应性。这些发现强调了评估有不明确排卵功能障碍妇女的心理和代谢背景的临床价值。结论:PCOM女性慢性心理应激与LH和卵巢内分泌输出的功能抑制有关,反映了PCOS典型内分泌表型的衰减,尽管多囊卵巢形态。瘦素调节个体对应激诱导的生殖抑制的易感性,作为下丘脑弹性的潜在许可信号。评估促性腺激素比率和代谢背景可能提高对排卵功能不清妇女的诊断准确性。
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引用次数: 0
Sex/gender differences in autistic traits, intelligence and executive functions of school-aged autistic children without intellectual disability 无智障的学龄自闭症儿童自闭症特征、智力和执行功能的性别差异。
IF 2.7 3区 医学 Q2 PSYCHIATRY Pub Date : 2026-01-07 DOI: 10.1007/s00737-025-01663-1
Katarína Polónyiová, Peter Teličák, Klaudia Kyselicová, Dóra Dukonyová, Daniela Ostatníková

Background

ASD has been more often diagnosed and researched in men than women, shaping diagnostic criteria which may not adequately capture the female presentation. Examining differences between girls and boys with ASD could enhance diagnostic accuracy and help reduce gender-related biases in research and clinical practice. The aim of this research was to analyze potential differences in autistic traits, intelligence, and executive functions of school-aged girls and boys diagnosed with ASD without intellectual disability.

Methods

The research sample consisted of 79 children with ASD, 20 girls and 59 boys, aged between 6 and 12 years. Autistic traits were measured by Autism Diagnostic Observation Schedule – Second Version and Autism Diagnostic Interview-Revised, intelligence by the Woodcock-Johnson International Editions II, and executive functions by Wisconsin Card Sorting Test and Behavior Rating Inventory of Executive Function 2.

Results

Girls scored lower in the amount of restricted, repetitive and stereotyped behaviors, but showed more severe deficits in Emotion Regulation, Cognitive Regulation and clinical scales Shift and Initiate, as measured by BRIEF-2.

Conclusion

Our results indicate girls with ASD exhibit certain differences from boys with ASD, which may be diagnostically relevant and helpful for their early detection and access to necessary resources and support. Nevertheless, extensive further research on the sex/gender differences and female ASD presentation is still needed.

背景:自闭症谱系障碍在男性中的诊断和研究多于女性,形成的诊断标准可能不能充分反映女性的表现。检查女孩和男孩自闭症患者之间的差异可以提高诊断的准确性,并有助于减少研究和临床实践中的性别偏见。本研究的目的是分析被诊断为ASD的学龄女孩和没有智力残疾的男孩在自闭症特征、智力和执行功能方面的潜在差异。方法:选取6 ~ 12岁的ASD患儿79例,其中女孩20例,男孩59例。自闭症特征采用《自闭症诊断观察表(第二版)》和《自闭症诊断访谈表(修订版)》测量,智力采用《伍德考克-约翰逊国际版(第二版)》测量,执行功能采用《威斯康星卡片分类测验》和《执行功能行为评定量表(第二版)》测量。结果:女孩在限制性、重复性和刻板行为的数量上得分较低,但在情绪调节、认知调节和临床量表Shift和Initiate中表现出更严重的缺陷。结论:我们的研究结果表明,ASD女孩与男孩表现出一定的差异,这可能与诊断相关,有助于他们的早期发现和获得必要的资源和支持。然而,对性别差异和女性自闭症表现的进一步研究仍需进一步深入。
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引用次数: 0
Postpartum retention in opioid agonist treatment for opioid dependence: A population-based cohort study 阿片受体激动剂治疗阿片类药物依赖的产后滞留:一项基于人群的队列研究。
IF 2.7 3区 医学 Q2 PSYCHIATRY Pub Date : 2026-01-06 DOI: 10.1007/s00737-025-01640-8
Joanna Zhou, Bianca Varney, Nicola Jones, Chrianna Bharat, Louisa Degenhardt, Alys Havard, Duong Thuy Tran

Purpose

Opioid agonist treatment (OAT) is the first-line treatment for opioid dependence during pregnancy and recommended for at least one year postpartum or until a strong maternal-infant bond and stable family environment is established. Evidence on postpartum OAT retention is limited. We examined retention rates and associated maternal characteristics.

Methods

We linked OAT prescription authority to perinatal, mortality, and other data sources. We identified all opioid-dependent women who gave birth in New South Wales, Australia (1 January 2004-31 March 2020) while receiving OAT. We defined retention at 90, 180, and 365 days postpartum as continuous treatment over each period. We calculated retention rates and used generalised linear modelling to examine association between retention and maternal socio-demographic and clinical factors.

Results

There were 3933 childbirths among 2514 women on OAT. Retention rates were 93.3% (n = 3670) at 90 days, 88.4% (n = 3475) at 180 days, and 78.5% (n = 3086) at 365 days. Retention at 180 days was lower for those who gave birth after 2015, were Indigenous, had recent conviction or incarceration, initiated OAT after conception, received buprenorphine, or had a mental illness. We observed similar association patterns at 90 and 365 days.

Conclusions

Among women on OAT at childbirth, postpartum treatment retention was high but varied across subgroups. Lower retention among women who initiated OAT late in pregnancy or with social or clinical risk factors highlights the need for targeted support. Lower buprenorphine retention warrants ongoing monitoring and tailored care, particularly in settings where it is the preferred treatment during pregnancy.

目的:阿片类激动剂治疗(OAT)是治疗妊娠期阿片类药物依赖的一线治疗方法,建议至少在产后一年或直到建立了牢固的母婴关系和稳定的家庭环境。产后OAT保留的证据有限。我们检查了保留率和相关的母体特征。方法:我们将OAT处方权威与围产期、死亡率和其他数据来源联系起来。我们确定了在澳大利亚新南威尔士州(2004年1月1日至2020年3月31日)接受OAT期间分娩的所有阿片类药物依赖妇女。我们将产后90,180和365天的保留定义为每个时期的持续治疗。我们计算了保留率,并使用广义线性模型来检验保留率与产妇社会人口统计学和临床因素之间的关系。结果:2514例经OAT检查的产妇共分娩3933例。90天留存率为93.3% (n = 3670), 180天留存率为88.4% (n = 3475), 365天留存率为78.5% (n = 3086)。对于2015年以后分娩、土著居民、最近被定罪或监禁、怀孕后开始OAT、服用丁丙诺啡或患有精神疾病的人来说,180天的保留率较低。我们在90天和365天观察到类似的关联模式。结论:在分娩时接受OAT治疗的妇女中,产后治疗保留率很高,但各亚组之间存在差异。在妊娠后期或有社会或临床风险因素的妇女中,OAT保留率较低,这突出了有针对性支持的必要性。丁丙诺啡潴留较低,需要持续监测和量身定制的护理,特别是在怀孕期间首选丁丙诺啡治疗的情况下。
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引用次数: 0
Sex differences in the independent and combined effects of genomic and exposomic risks for schizophrenia on distressing psychotic experiences: insights from the ABCD study 精神分裂症基因组和暴露风险对痛苦精神病经历的独立和联合影响的性别差异:来自ABCD研究的见解。
IF 2.7 3区 医学 Q2 PSYCHIATRY Pub Date : 2026-01-06 DOI: 10.1007/s00737-025-01644-4
Thanavadee Prachason, Angelo Arias-Magnasco, Bochao Danae Lin, Jim van Os, Bart P. F. Rutten, Lotta-Katrin Pries, Sinan Guloksuz

Purpose

To investigate sex-dependent effects of polygenic risk (PRS-SCZ) and exposome score (ES-SCZ) for schizophrenia, both independently and jointly, on distressing psychotic experiences (PEs) in early adolescents.

Method

Baseline to 3-year follow-up data of the Adolescent Brain and Cognitive Development Study (ABCD) were used. PRS-SCZ and ES-SCZ were calculated to assess cumulative genetic and environmental (childhood adversity, cannabis use, hearing impairment, and winter births) risk for schizophrenia, respectively. The primary outcome was past-month distressing PEs at the 3-year follow-up. Secondary outcomes included distressing PEs across four yearly assessments: lifetime (≥ 1 wave), repeated (≥ 2 or ≥ 3 waves), and persisting (≥ 4 waves). Sex-stratified multilevel logistic regression models were used to test the independent and joint associations of binary modes (> 75th percentile) of PRS-SCZ (PRS-SCZ75) and ES-SCZ (ES-SCZ75) on the outcomes. As sensitivity analysis, the sex-stratified analyses were repeated on a randomly selected unrelated sample, and the coefficients of males and females were compared.

Results

PRS-SCZ75 was not associated with past-month distressing PEs in either sex but significantly associated with lifetime and repeated (≥ 2 waves) distressing PEs only in females. In both sexes, ES-SCZ75 was significantly associated with all PE outcomes but did not additively interact with PRS-SCZ75 in predicting them. Sensitivity analysis confirmed the findings and revealed a significant sex difference in the association between PRS-SCZ75 and lifetime distressing PEs.

Conclusion

The influence of genomic risk for schizophrenia on distressing PEs might be sex-dependent, whereas that of the exposomic risk was universal in early adolescence. Further studies in larger samples are needed.

目的:探讨多基因风险(PRS-SCZ)和暴露评分(ES-SCZ)对青少年早期精神分裂症患者痛苦精神病经历(PEs)的性别依赖效应。方法:采用青少年脑与认知发展研究(ABCD)基线至3年随访资料。计算PRS-SCZ和ES-SCZ分别用于评估精神分裂症的累积遗传和环境风险(童年逆境、大麻使用、听力障碍和冬季分娩)。在3年的随访中,主要结果是过去一个月的痛苦pe。次要结果包括四次年度评估中的痛苦pe:终生(≥1波)、重复(≥2或≥3波)和持续(≥4波)。采用性别分层多水平logistic回归模型检验PRS-SCZ (PRS-SCZ75)和ES-SCZ (ES-SCZ75)二元模式(> - 75百分位)对预后的独立关联和联合关联。作为敏感性分析,对随机选取的不相关样本重复性别分层分析,比较男性和女性的系数。结果:PRS-SCZ75与两性过去一个月的苦恼性pe无关,但仅与女性终生和重复(≥2波)苦恼性pe显著相关。在两性中,ES-SCZ75与所有PE结果显著相关,但与PRS-SCZ75在预测PE结果方面没有相互作用。敏感性分析证实了这一发现,并揭示了PRS-SCZ75与终生苦恼性pe之间存在显著的性别差异。结论:精神分裂症基因组风险对痛苦性pe的影响可能具有性别依赖性,而暴露性风险在青春期早期具有普遍性。需要对更大的样本进行进一步的研究。
{"title":"Sex differences in the independent and combined effects of genomic and exposomic risks for schizophrenia on distressing psychotic experiences: insights from the ABCD study","authors":"Thanavadee Prachason,&nbsp;Angelo Arias-Magnasco,&nbsp;Bochao Danae Lin,&nbsp;Jim van Os,&nbsp;Bart P. F. Rutten,&nbsp;Lotta-Katrin Pries,&nbsp;Sinan Guloksuz","doi":"10.1007/s00737-025-01644-4","DOIUrl":"10.1007/s00737-025-01644-4","url":null,"abstract":"<div><h3>Purpose</h3><p>To investigate sex-dependent effects of polygenic risk (PRS-SCZ) and exposome score (ES-SCZ) for schizophrenia, both independently and jointly, on distressing psychotic experiences (PEs) in early adolescents.</p><h3>Method</h3><p>Baseline to 3-year follow-up data of the Adolescent Brain and Cognitive Development Study (ABCD) were used. PRS-SCZ and ES-SCZ were calculated to assess cumulative genetic and environmental (childhood adversity, cannabis use, hearing impairment, and winter births) risk for schizophrenia, respectively. The primary outcome was past-month distressing PEs at the 3-year follow-up. Secondary outcomes included distressing PEs across four yearly assessments: lifetime (≥ 1 wave), repeated (≥ 2 or ≥ 3 waves), and persisting (≥ 4 waves). Sex-stratified multilevel logistic regression models were used to test the independent and joint associations of binary modes (&gt; 75th percentile) of PRS-SCZ (PRS-SCZ<sub>75</sub>) and ES-SCZ (ES-SCZ<sub>75</sub>) on the outcomes. As sensitivity analysis, the sex-stratified analyses were repeated on a randomly selected unrelated sample, and the coefficients of males and females were compared.</p><h3>Results</h3><p>PRS-SCZ<sub>75</sub> was not associated with past-month distressing PEs in either sex but significantly associated with lifetime and repeated (≥ 2 waves) distressing PEs only in females. In both sexes, ES-SCZ<sub>75</sub> was significantly associated with all PE outcomes but did not additively interact with PRS-SCZ<sub>75</sub> in predicting them. Sensitivity analysis confirmed the findings and revealed a significant sex difference in the association between PRS-SCZ<sub>75</sub> and lifetime distressing PEs.</p><h3>Conclusion</h3><p>The influence of genomic risk for schizophrenia on distressing PEs might be sex-dependent, whereas that of the exposomic risk was universal in early adolescence. Further studies in larger samples are needed.</p></div>","PeriodicalId":8369,"journal":{"name":"Archives of Women's Mental Health","volume":"29 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00737-025-01644-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145910203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mental health service utilization in a novel insurance-based Ob/Gyn integrated model for women across the lifespan 心理健康服务的利用在一个新的基于保险的妇产科综合模式为妇女的整个生命周期。
IF 2.7 3区 医学 Q2 PSYCHIATRY Pub Date : 2026-01-05 DOI: 10.1007/s00737-025-01652-4
Andréane Lavallée, Vanessa Babineau, Kristina D’Antonio, Elizabeth Werner, Andrew T. Drysdale, Madalyn Osbourne, Myrriam Grubb, Nathalie Moise, Inbal Reuveni, Zhijun Zhang, Seonjoo Lee, Dani Dumitriu, Mary D’Alton, Catherine Monk

Purpose

Women’s Mental Health @Obstetrics and Gynecology (WMH @Ob/Gyn) is a novel, insurance-based clinical model integrated in Ob/Gyn practices that offers approachable, acceptable, available, and affordable mental healthcare to women across the lifespan. Women seen by Ob/Gyn physicians for physical healthcare needs are referred to the WMH @Ob/Gyn service based on patient request, provider observation, and/or results on universal depression screening. WMH@Ob/Gyn’ services include mental health screening, psychotherapy, psychopharmacology and support groups, all embedded into Ob/Gyn. Here, we sought to evaluate utilization rates of mental health services as an outcome of increased access resulting from real-world implementation of WMH @Ob/Gyn.

Methods

This prospective observational cohort study followed all patients referred to WMH @Ob/Gyn from 02/2020 to 12/2022. Data were obtained from a clinical registry and patient electronic health records. Utilization was estimated on initiation (proportion of women who attended at least one mental health visit), and sustainment (proportion of women who attended three or more visits).

Results

2,661 women were referred to WMH @Ob/Gyn; 65% initiated, out of which 36% sustained treatment. Hispanic/Latina/Spanish women were less likely to initiate treatment. Of those who initiated, women whose insurance was non-participating in mental healthcare, women that were not pregnant, and younger women, had lower odds of sustaining treatment.

Conclusion

WMH @Ob/Gyn facilitates the initiation and sustainment of mental health treatment at rates considerably higher than those observed in comparable perinatal-integrated programs or the general population. However, persistent systemic barriers, including disparities in physical and mental health insurance coverage, continue to constrain equitable, sustained access to mental healthcare.

目的:妇产科妇女心理健康(WMH @Ob/Gyn)是一种新颖的、基于保险的临床模式,整合在妇产科实践中,为妇女提供平易近人、可接受、可用和负担得起的心理保健。根据患者的要求、医生的观察和/或普遍抑郁症筛查的结果,由妇产科医生为身体保健需求就诊的妇女被转介到WMH @妇产科服务。WMH@Ob/Gyn的服务包括心理健康检查、心理治疗、精神药理学和支持小组,所有这些都纳入妇产科。在这里,我们试图评估精神卫生服务的利用率,作为现实世界实施WMH @Ob/Gyn增加获取机会的结果。方法本前瞻性观察队列研究随访了2020年2月至2022年12月在WMH @Ob/Gyn就诊的所有患者。数据来自临床登记和患者电子健康记录。根据开始(至少参加一次心理健康就诊的妇女的比例)和维持(参加三次或三次以上就诊的妇女的比例)估计利用情况。结果2661名妇女转诊至WMH @妇产科;65%开始治疗,其中36%持续治疗。西班牙裔/拉丁裔/西班牙裔妇女开始治疗的可能性较小。在那些开始的人中,那些没有参加精神保健保险的妇女、没有怀孕的妇女和年轻妇女坚持治疗的几率较低。结论wmh @Ob/Gyn促进心理健康治疗的启动和维持率明显高于围产期综合项目或一般人群。然而,持续存在的系统性障碍,包括身体和精神健康保险覆盖面的差异,继续限制公平、持续地获得精神保健服务。
{"title":"Mental health service utilization in a novel insurance-based Ob/Gyn integrated model for women across the lifespan","authors":"Andréane Lavallée,&nbsp;Vanessa Babineau,&nbsp;Kristina D’Antonio,&nbsp;Elizabeth Werner,&nbsp;Andrew T. Drysdale,&nbsp;Madalyn Osbourne,&nbsp;Myrriam Grubb,&nbsp;Nathalie Moise,&nbsp;Inbal Reuveni,&nbsp;Zhijun Zhang,&nbsp;Seonjoo Lee,&nbsp;Dani Dumitriu,&nbsp;Mary D’Alton,&nbsp;Catherine Monk","doi":"10.1007/s00737-025-01652-4","DOIUrl":"10.1007/s00737-025-01652-4","url":null,"abstract":"<div><h3>Purpose</h3><p>Women’s Mental Health @Obstetrics and Gynecology (WMH @Ob/Gyn) is a novel, insurance-based clinical model integrated in Ob/Gyn practices that offers approachable, acceptable, available, and affordable mental healthcare to women across the lifespan. Women seen by Ob/Gyn physicians for physical healthcare needs are referred to the WMH @Ob/Gyn service based on patient request, provider observation, and/or results on universal depression screening. WMH@Ob/Gyn’ services include mental health screening, psychotherapy, psychopharmacology and support groups, all embedded into Ob/Gyn. Here, we sought to evaluate utilization rates of mental health services as an outcome of increased access resulting from real-world implementation of WMH @Ob/Gyn.</p><h3>Methods</h3><p>This prospective observational cohort study followed all patients referred to WMH @Ob/Gyn from 02/2020 to 12/2022. Data were obtained from a clinical registry and patient electronic health records. Utilization was estimated on initiation (proportion of women who attended at least one mental health visit), and sustainment (proportion of women who attended three or more visits). </p><h3>Results</h3><p>2,661 women were referred to WMH @Ob/Gyn; 65% initiated, out of which 36% sustained treatment. Hispanic/Latina/Spanish women were less likely to initiate treatment. Of those who initiated, women whose insurance was non-participating in mental healthcare, women that were not pregnant, and younger women, had lower odds of sustaining treatment. </p><h3>Conclusion</h3><p>WMH @Ob/Gyn facilitates the initiation and sustainment of mental health treatment at rates considerably higher than those observed in comparable perinatal-integrated programs or the general population. However, persistent systemic barriers, including disparities in physical and mental health insurance coverage, continue to constrain equitable, sustained access to mental healthcare. </p></div>","PeriodicalId":8369,"journal":{"name":"Archives of Women's Mental Health","volume":"29 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12765718/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145899114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A critical reappraisal of the PROMUD program: bridging the 20-year gap in women’s substance use disorder treatment 对PROMUD项目的重要重新评估:弥合妇女物质使用障碍治疗20年的差距。
IF 2.7 3区 医学 Q2 PSYCHIATRY Pub Date : 2026-01-03 DOI: 10.1007/s00737-025-01645-3
Sahar Saleem, Mariam Azam, Mamoona Muneer
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引用次数: 0
Associations between attentional disengagement from distressed infant faces and cortisol reactivity are moderated by depressive symptoms in pregnant women: an eye-tracking study 一项眼动追踪研究显示,孕妇抑郁症状缓和了对痛苦婴儿面孔的注意力脱离与皮质醇反应之间的关联。
IF 2.7 3区 医学 Q2 PSYCHIATRY Pub Date : 2026-01-03 DOI: 10.1007/s00737-025-01638-2
Christine Dworschak, Gabriela Paganini, Abigail Beech, Kelley E. Gunther, Helena J. V. Rutherford, Jutta Joormann, Reuma Gadassi-Polack

Purpose

Antenatal depression is a common psychological condition in pregnancy that negatively influences parenting. Theoretical models suggest that infant cue processing may represent one pathway by which depression may influence parenting. However, current understanding of how infant cue processing is linked with parenting in depression remains limited. Drawing upon previous research, cortisol stress reactivity may play an important role in this regard. The aim of the present study was to investigate the interaction between depressive symptoms and attentional disengagement from infant cues on cortisol reactivity. We examined this in a sample of pregnant and nulliparous women to test whether potential effects were specific to pregnancy.

Methods

N = 79 women (n = 36 pregnant) completed two eye-tracking tasks examining disengagement from adult and infant stimuli, a stress manipulation task including collection of salivary cortisol, and filled out the BDI-II.

Results

Pregnant (vs. nulliparous) women showed a stronger cortisol reactivity in response to a stress test. Additionally, a significant association between disengagement from distressed infant faces and cortisol reactivity was found in the pregnant (but not nulliparous) group, which was moderated by depressive symptoms. For pregnant women with low levels of depressive symptoms, a slower disengagement from distressed infant stimuli predicted a weaker cortisol reactivity in response to stress, while the opposite pattern was observed for pregnant women with high levels of depressive symptoms.

Conclusions

Findings of the present study point at maternal distress during processing of infant distress as a potential intervention target for mothers with depression.

目的:产前抑郁是妊娠期常见的心理状况,对养育子女产生负面影响。理论模型表明,婴儿的线索处理可能是抑郁症影响育儿的一个途径。然而,目前对婴儿线索处理与父母在抑郁症中的关系的理解仍然有限。根据以往的研究,皮质醇应激反应可能在这方面发挥重要作用。本研究的目的是探讨抑郁症状与婴儿皮质醇反应线索的注意脱离之间的相互作用。我们在孕妇和未生育妇女的样本中检验了这一点,以测试潜在的影响是否仅针对妊娠。方法:79名妇女(36名孕妇)分别完成成人和婴儿刺激下的眼动追踪测试、唾液皮质醇压力控制测试,并填写BDI-II。结果:怀孕(与未分娩相比)的妇女在压力测试中表现出更强的皮质醇反应。此外,在怀孕(但不是未生育)组中,从痛苦婴儿的面孔中脱离与皮质醇反应之间存在显著关联,这被抑郁症状所缓和。对于抑郁症状程度较低的孕妇,较慢地脱离痛苦婴儿的刺激预示着较弱的皮质醇对压力的反应,而在抑郁症状程度较高的孕妇中观察到相反的模式。结论:本研究结果表明,在处理婴儿痛苦时,母亲的痛苦是抑郁症母亲的潜在干预目标。
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引用次数: 0
Daughters-in-law’s perceptions and experiences with MILAP, a family-based intervention to reduce intimate partner violence and improve mental health in Nepal 儿媳对家庭暴力干预计划的看法和经验,这是一项以家庭为基础的干预措施,旨在减少尼泊尔的亲密伴侣暴力和改善精神健康。
IF 2.7 3区 医学 Q2 PSYCHIATRY Pub Date : 2026-01-03 DOI: 10.1007/s00737-025-01643-5
Saugat Joshi, Rekha Khatri, Jene Shrestha, Mina Shrestha, Shuvam Sharma, Pragya Rimal, Dikshya Sharma, Sajama Nepali, Kripa Sigdel, Srijana Shrestha, Sumitra Poudel, Sunita Mainali, Meghnath Dhimal, Bibhav Acharya, Sabitri Sapkota

Background

Intimate partner violence (IPV) and mental health (MH) issues among women in Nepal are deeply influenced by complex intergenerational family dynamics and power hierarchies. The traditional power hierarchies often place mothers-in-law (MILs) in authoritative roles over daughters-in-law (DILs), limiting the latter’s autonomy and decision-making power. We designed a multi-component family intervention called MILAP to lower depression and address intimate partner violence by improving communication, promoting gender equity, and improving family relationships. This paper explores the perceptions and experiences of DILs who received the MILAP intervention.

Methods

A total of 61 families participated in a pilot study of the MILAP intervention. Of these, 8 families (comprising triads of daughter-in-law, mother-in-law, and husband) were purposively selected for in-depth interviews (IDIs). All interviews were conducted immediately after the intervention and at the 6-month follow-up to assess MILAP’s sustainability and impact. A thematic approach was used to analyze the data, utilizing Dedoose data management software.

Results

Four major themes were identified: (1) Enhanced communication within the family, (2) Strengthened DIL’s empowerment, (3) Improved relationship quality, and (4) Increased DIL’s freedom of movement. Participants reported improvement in communication among family members, particularly by using active listening skills which in turn contributed to conflict reduction and a more harmonious family environment. DILs experienced increased empowerment. They were more involved in family decision-making as the family unit adopted more equitable gender norms. The intervention strengthened spousal relationship improved MIL-DIL interactions, facilitated mutual understanding, and reduced household stress. Additionally, MILAP enabled DILs to move more freely outside the home. This increased mobility expanded their social networks, as DILs participated in community events, visited natal families, and accessed health services. However, some participants expressed concerns about the long-term sustainability of these changes, highlighting the need for continued reinforcement.

Conclusion

Our study underscores the importance of a family-based intervention in improving relationship quality and promoting autonomy among DILs experiencing IPV. The positive shifts perceived within families suggest promise for MILAP to strengthen support structures and address factors that may influence DIL’s mental health. However, ongoing follow-up and reinforcement strategies are recommended to maintain the gains achieved from the intervention.

背景:尼泊尔妇女的亲密伴侣暴力(IPV)和心理健康(MH)问题深受复杂的代际家庭动态和权力等级的影响。传统的权力等级制度往往将婆婆置于儿媳的权威地位,限制了儿媳的自主权和决策权。我们设计了一种名为MILAP的多成分家庭干预,通过改善沟通、促进性别平等和改善家庭关系来降低抑郁症和解决亲密伴侣暴力问题。本文探讨了接受MILAP干预的dill的认知和经验。方法:共有61个家庭参与了MILAP干预的试点研究。其中,有目的地选取8个家庭(媳妇、婆婆、丈夫三合一)进行深度访谈(IDIs)。所有访谈均在干预后立即进行,并在6个月的随访期间进行,以评估MILAP的可持续性和影响。采用专题方法,利用Dedoose数据管理软件对数据进行分析。结果:确定了四个主要主题:(1)加强家庭内部的沟通,(2)加强DIL的授权,(3)改善关系质量,(4)增加DIL的行动自由。参与者报告说,家庭成员之间的沟通有所改善,特别是通过使用积极的倾听技巧,这反过来又有助于减少冲突和建立更和谐的家庭环境。dill获得了更多的授权。随着家庭单位采用更公平的性别规范,她们更多地参与家庭决策。干预加强了配偶关系,改善了MIL-DIL互动,促进了相互理解,减少了家庭压力。此外,MILAP使伤残人员能够更自由地在家庭以外活动。这种增加的流动性扩大了他们的社会网络,因为外勤人员参加了社区活动,访问了出生家庭,并获得了保健服务。但是,一些与会者对这些变化的长期可持续性表示关切,强调需要继续加强。结论:我们的研究强调了以家庭为基础的干预在改善经历IPV的DILs关系质量和促进自主性方面的重要性。家庭内部感知到的积极转变表明MILAP有希望加强支持结构并解决可能影响DIL心理健康的因素。然而,建议采取持续的后续行动和加强战略,以保持干预所取得的成果。
{"title":"Daughters-in-law’s perceptions and experiences with MILAP, a family-based intervention to reduce intimate partner violence and improve mental health in Nepal","authors":"Saugat Joshi,&nbsp;Rekha Khatri,&nbsp;Jene Shrestha,&nbsp;Mina Shrestha,&nbsp;Shuvam Sharma,&nbsp;Pragya Rimal,&nbsp;Dikshya Sharma,&nbsp;Sajama Nepali,&nbsp;Kripa Sigdel,&nbsp;Srijana Shrestha,&nbsp;Sumitra Poudel,&nbsp;Sunita Mainali,&nbsp;Meghnath Dhimal,&nbsp;Bibhav Acharya,&nbsp;Sabitri Sapkota","doi":"10.1007/s00737-025-01643-5","DOIUrl":"10.1007/s00737-025-01643-5","url":null,"abstract":"<div><h3>Background</h3><p>Intimate partner violence (IPV) and mental health (MH) issues among women in Nepal are deeply influenced by complex intergenerational family dynamics and power hierarchies. The traditional power hierarchies often place mothers-in-law (MILs) in authoritative roles over daughters-in-law (DILs), limiting the latter’s autonomy and decision-making power. We designed a multi-component family intervention called MILAP to lower depression and address intimate partner violence by improving communication, promoting gender equity, and improving family relationships. This paper explores the perceptions and experiences of DILs who received the MILAP intervention.</p><h3>Methods</h3><p>A total of 61 families participated in a pilot study of the MILAP intervention. Of these, 8 families (comprising triads of daughter-in-law, mother-in-law, and husband) were purposively selected for in-depth interviews (IDIs). All interviews were conducted immediately after the intervention and at the 6-month follow-up to assess MILAP’s sustainability and impact. A thematic approach was used to analyze the data, utilizing Dedoose data management software.</p><h3>Results</h3><p>Four major themes were identified: (1) Enhanced communication within the family, (2) Strengthened DIL’s empowerment, (3) Improved relationship quality, and (4) Increased DIL’s freedom of movement. Participants reported improvement in communication among family members, particularly by using active listening skills which in turn contributed to conflict reduction and a more harmonious family environment. DILs experienced increased empowerment. They were more involved in family decision-making as the family unit adopted more equitable gender norms. The intervention strengthened spousal relationship improved MIL-DIL interactions, facilitated mutual understanding, and reduced household stress. Additionally, MILAP enabled DILs to move more freely outside the home. This increased mobility expanded their social networks, as DILs participated in community events, visited natal families, and accessed health services. However, some participants expressed concerns about the long-term sustainability of these changes, highlighting the need for continued reinforcement.</p><h3>Conclusion</h3><p>Our study underscores the importance of a family-based intervention in improving relationship quality and promoting autonomy among DILs experiencing IPV. The positive shifts perceived within families suggest promise for MILAP to strengthen support structures and address factors that may influence DIL’s mental health. However, ongoing follow-up and reinforcement strategies are recommended to maintain the gains achieved from the intervention.</p></div>","PeriodicalId":8369,"journal":{"name":"Archives of Women's Mental Health","volume":"29 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145896177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Global prevalence and associated factors of severe fear of childbirth: a systematic review and Meta-Analysis 严重分娩恐惧的全球患病率及相关因素:系统回顾和荟萃分析
IF 2.7 3区 医学 Q2 PSYCHIATRY Pub Date : 2026-01-02 DOI: 10.1007/s00737-025-01648-0
Mahsa Maghalian, Zohreh Alizadeh-Dibazari, Mojgan Mirghafourvand

Background

Fear of childbirth (FoC), particularly its severe form (tokophobia), is a significant public health concern associated with adverse maternal and neonatal outcomes. While previous meta-analyses have provided global prevalence estimates, significant knowledge gaps remain due to limited studies. This study aimed to provide an updated global prevalence estimate of severe FoC and explore sources of heterogeneity and associated risk factors.

Methods

A systematic review and meta-analysis was conducted following PRISMA and MOOSE guidelines. We searched international and Persian databases from inception until June 2025 for cross-sectional and cohort studies reporting severe FoC prevalence in pregnant women using validated tools with defined cutoffs. Two reviewers independently performed data extraction and quality assessment using the Newcastle-Ottawa Scale. Random-effects models were used for meta-analysis, with heterogeneity assessed via I² statistic. Subgroup analyses and meta-regressions explored variation sources. Risk factors were synthesized descriptively, though nulliparity and unplanned pregnancy allowed meta-analysis.

Results

From 67 included studies (n = 905,504 participants), the pooled prevalence of severe FoC was 16.5% (95% CI: 13.8–19.5%), with significant heterogeneity (I² = 99.45%). Assessment tools and cutoffs were major heterogeneity sources (p < 0.001), with prevalence ranging from 3.7% to 58.7%. Country of study was also a significant moderator (p < 0.001). Meta-regression showed no significant association with maternal age, gestational age, nulliparity percentage, or publication year. Key risk factors included previous traumatic birth, anxiety/depression symptoms, and inadequate social support. Nulliparous women had higher odds of severe FoC (OR = 1.36, 95% CI: 1.04–1.76), as did those with unplanned pregnancy (OR = 1.85, 95% CI: 1.29–2.65).

Conclusion

Severe FoC affects approximately one in six women globally. The substantial heterogeneity, largely due to methodological variations, underscores the need for standardized assessment protocols. Identified associations with factors such as previous traumatic birth and anxiety highlight the condition’s multifactorial nature, emphasizing the importance of targeted screening and evidence-based interventions aligned with Sustainable Development Goal (SDG) 3 to improve maternal mental health.

分娩恐惧(FoC),特别是其严重形式(分娩恐惧症),是一个与孕产妇和新生儿不良结局相关的重大公共卫生问题。虽然以前的荟萃分析提供了全球患病率估计,但由于研究有限,仍然存在重大的知识差距。本研究旨在提供最新的全球严重FoC患病率估计,并探讨异质性来源和相关危险因素。方法按照PRISMA和MOOSE指南进行系统评价和荟萃分析。我们检索了国际和波斯数据库,从一开始到2025年6月,使用有效的工具和明确的截止点,对报告孕妇严重FoC患病率的横断面和队列研究进行了检索。两名审稿人使用纽卡斯尔-渥太华量表独立进行数据提取和质量评估。meta分析采用随机效应模型,通过I²统计量评估异质性。亚组分析和元回归探讨了变异的来源。危险因素是描述性地综合的,尽管未生育和意外怀孕允许荟萃分析。结果纳入的67项研究(n = 905,504名受试者)中,重度FoC的总患病率为16.5% (95% CI: 13.8-19.5%),异质性显著(I²= 99.45%)。评估工具和截止点是主要的异质性来源(p < 0.001),患病率从3.7%到58.7%不等。研究国家也是一个显著的调节因素(p < 0.001)。meta回归显示与产妇年龄、胎龄、无产率或出版年份无显著相关性。主要危险因素包括以前的创伤性分娩、焦虑/抑郁症状和社会支持不足。未生育妇女发生严重FoC的几率更高(OR = 1.36, 95% CI: 1.04-1.76),计划外妊娠妇女也是如此(OR = 1.85, 95% CI: 1.29-2.65)。结论:全球约六分之一的女性患有严重的FoC。很大程度上由于方法的不同而存在很大的不一致性,这突出了标准化评价方案的必要性。已确定的与先前创伤性分娩和焦虑等因素的关联突出了该病的多因素性质,强调了有针对性的筛查和循证干预措施的重要性,这些措施符合可持续发展目标3,以改善孕产妇心理健康。
{"title":"Global prevalence and associated factors of severe fear of childbirth: a systematic review and Meta-Analysis","authors":"Mahsa Maghalian,&nbsp;Zohreh Alizadeh-Dibazari,&nbsp;Mojgan Mirghafourvand","doi":"10.1007/s00737-025-01648-0","DOIUrl":"10.1007/s00737-025-01648-0","url":null,"abstract":"<div><h3>Background</h3><p>Fear of childbirth (FoC), particularly its severe form (tokophobia), is a significant public health concern associated with adverse maternal and neonatal outcomes. While previous meta-analyses have provided global prevalence estimates, significant knowledge gaps remain due to limited studies. This study aimed to provide an updated global prevalence estimate of severe FoC and explore sources of heterogeneity and associated risk factors.</p><h3>Methods</h3><p>A systematic review and meta-analysis was conducted following PRISMA and MOOSE guidelines. We searched international and Persian databases from inception until June 2025 for cross-sectional and cohort studies reporting severe FoC prevalence in pregnant women using validated tools with defined cutoffs. Two reviewers independently performed data extraction and quality assessment using the Newcastle-Ottawa Scale. Random-effects models were used for meta-analysis, with heterogeneity assessed via I² statistic. Subgroup analyses and meta-regressions explored variation sources. Risk factors were synthesized descriptively, though nulliparity and unplanned pregnancy allowed meta-analysis.</p><h3>Results</h3><p>From 67 included studies (<i>n</i> = 905,504 participants), the pooled prevalence of severe FoC was 16.5% (95% CI: 13.8–19.5%), with significant heterogeneity (I² = 99.45%). Assessment tools and cutoffs were major heterogeneity sources (<i>p</i> &lt; 0.001), with prevalence ranging from 3.7% to 58.7%. Country of study was also a significant moderator (<i>p</i> &lt; 0.001). Meta-regression showed no significant association with maternal age, gestational age, nulliparity percentage, or publication year. Key risk factors included previous traumatic birth, anxiety/depression symptoms, and inadequate social support. Nulliparous women had higher odds of severe FoC (OR = 1.36, 95% CI: 1.04–1.76), as did those with unplanned pregnancy (OR = 1.85, 95% CI: 1.29–2.65).</p><h3>Conclusion</h3><p>Severe FoC affects approximately one in six women globally. The substantial heterogeneity, largely due to methodological variations, underscores the need for standardized assessment protocols. Identified associations with factors such as previous traumatic birth and anxiety highlight the condition’s multifactorial nature, emphasizing the importance of targeted screening and evidence-based interventions aligned with Sustainable Development Goal (SDG) 3 to improve maternal mental health.</p></div>","PeriodicalId":8369,"journal":{"name":"Archives of Women's Mental Health","volume":"29 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145886847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Family Planning Belief Index (FPBI) as a measure to refurbish contraceptive counselling: evidence from Rural Odisha, India 计划生育信念指数(FPBI)作为更新避孕咨询的措施:来自印度奥里萨邦农村的证据。
IF 2.7 3区 医学 Q2 PSYCHIATRY Pub Date : 2025-12-05 DOI: 10.1007/s00737-025-01627-5
Sonali Kar, Pramod Chandra Samantaray
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引用次数: 0
期刊
Archives of Women's Mental Health
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