Pub Date : 2024-01-16DOI: 10.1097/APO.0000000000000575
Mona Bhargava, Raj S Paul, Karan R Nathani
{"title":"Spontaneous Regression and Recurrence of Corneal Intrastromal Cyst.","authors":"Mona Bhargava, Raj S Paul, Karan R Nathani","doi":"10.1097/APO.0000000000000575","DOIUrl":"https://doi.org/10.1097/APO.0000000000000575","url":null,"abstract":"","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139490779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-16DOI: 10.1097/APO.0000000000000601
Sasha Zaki
{"title":"Integration of Massive Open Online Course (MOOC) in Ophthalmic Skills Training for Medical Students: Outcomes and Perspectives.","authors":"Sasha Zaki","doi":"10.1097/APO.0000000000000601","DOIUrl":"https://doi.org/10.1097/APO.0000000000000601","url":null,"abstract":"","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139490774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-01DOI: 10.1016/j.apjo.2023.100002
Jiahui Chen , Shaohua Zhang , Fan Yang , Yongxiang Jiang , Yi Lu , Yating Tang
Purpose
To investigate the current prevalence and causes of moderate and severe visual impairment (MSVI) and blindness in elderly people in suburban Shanghai, China.
Methods
A cross-sectional study based on the population was conducted, which involved 5846 individuals (11,692 eyes) aged 65 years or older. Thorough eye examinations were performed to assess the prevalence and leading factors of MSVI (BCVA <20/63 to ≥20/400) and blindness (BCVA <20/400).
Results
The standardized prevalence of bilateral MSVI and blindness was 3.3% and 0.6%, correspondingly. The standardized prevalence of monocular MSVI and blindness was 7.4% and 2.0%, correspondingly. Cataract (47.9% and 20.7%, correspondingly) and myopic macular degeneration (MMD, 25.7% and 31.1%, correspondingly) were the principal causes of bilateral MSVI and blindness. As for monocular MSVI, the primary causes were cataract (39.4%), age-related macular degeneration (AMD, 16.6%), and MMD (16.6%). The primary causes of monocular blindness were other posterior segment eye diseases (30.1%) and MMD (14.2%). In adults aged 65–74 years, MMD was the foremost factor causing bilateral vision impairment. Conversely, cataract was identified as the primary cause of bilateral and monocular vision impairment among adults aged ≥ 75 years. AMD accounts for a significant proportion of individuals across all age groups.
Conclusions
The significant prevalence of MSVI and blindness among Chinese adults represents a critical public health issue. In addition to cataract, the vision impairment caused by MMD and AMD become an important issue in the elderly Chinese people.
{"title":"Prevalence and causes of vision impairment in elderly Chinese people living in suburban Shanghai","authors":"Jiahui Chen , Shaohua Zhang , Fan Yang , Yongxiang Jiang , Yi Lu , Yating Tang","doi":"10.1016/j.apjo.2023.100002","DOIUrl":"https://doi.org/10.1016/j.apjo.2023.100002","url":null,"abstract":"<div><h3>Purpose</h3><p>To investigate the current prevalence and causes of moderate and severe visual impairment (MSVI) and blindness in elderly people in suburban Shanghai, China.</p></div><div><h3>Methods</h3><p>A cross-sectional study based on the population was conducted, which involved 5846 individuals (11,692 eyes) aged 65 years or older. Thorough eye examinations were performed to assess the prevalence and leading factors of MSVI (BCVA <20/63 to ≥20/400) and blindness (BCVA <20/400).</p></div><div><h3>Results</h3><p>The standardized prevalence of bilateral MSVI and blindness was 3.3% and 0.6%, correspondingly. The standardized prevalence of monocular MSVI and blindness was 7.4% and 2.0%, correspondingly. Cataract (47.9% and 20.7%, correspondingly) and myopic macular degeneration (MMD, 25.7% and 31.1%, correspondingly) were the principal causes of bilateral MSVI and blindness. As for monocular MSVI, the primary causes were cataract (39.4%), age-related macular degeneration (AMD, 16.6%), and MMD (16.6%). The primary causes of monocular blindness were other posterior segment eye diseases (30.1%) and MMD (14.2%). In adults aged 65–74 years, MMD was the foremost factor causing bilateral vision impairment. Conversely, cataract was identified as the primary cause of bilateral and monocular vision impairment among adults aged ≥ 75 years. AMD accounts for a significant proportion of individuals across all age groups.</p></div><div><h3>Conclusions</h3><p>The significant prevalence of MSVI and blindness among Chinese adults represents a critical public health issue. In addition to cataract, the vision impairment caused by MMD and AMD become an important issue in the elderly Chinese people.</p></div>","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2162098923000026/pdfft?md5=b994087682017880e15ca2632b5a33b4&pid=1-s2.0-S2162098923000026-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139901547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-01DOI: 10.1097/APO.0000000000000600
Zijing Huang, Haoyu Chen
{"title":"Response to Letter to the Editor: “Integration of Massive Open Online Course (MOOC) in Ophthalmic Skills Training for Medical Students: Outcomes and Perspectives”","authors":"Zijing Huang, Haoyu Chen","doi":"10.1097/APO.0000000000000600","DOIUrl":"10.1097/APO.0000000000000600","url":null,"abstract":"","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2162098924000239/pdfft?md5=08c6ea492edf23fe72227e886d478d02&pid=1-s2.0-S2162098924000239-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139490776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-01DOI: 10.1016/j.apjo.2023.100033
Yunhe Song , Fengbin Lin , Aiguo Lv , Yao Zhang , Lan Lu , Lin Xie , Guangxian Tang , Huiping Yuan , Yangfan Yang , Jiangang Xu , Ping Lu , Meichun Xiao , Xiaomin Zhu , Xiaowei Yan , Wulian Song , Xiaoyan Li , Hengli Zhang , Fei Li , Zhenyu Wang , Ling Jin , Xiulan Zhang
Purpose
To investigate the effectiveness and safety of phacogoniotomy versus phacotrabeculectomy (PVP) among patients with advanced primary angle-closure glaucoma (PACG) and cataracts.
A total of 124 patients (124 eyes) with advanced PACG and cataracts were enrolled, with 65 in the phacogoniotomy group and 59 in the phacotrabeculectomy group. Patients were followed up for 12 months with standardized evaluations. The primary outcome was the reduction in intraocular pressure (IOP) from baseline to 12 months postoperatively, of which a non-inferiority margin of 4 mmHg was evaluated. Secondary outcomes included the cumulative surgical success rate, postoperative complications, and changes in the number of glaucoma medications.
Results
After 12 months, phacogoniotomy demonstrated non-inferiority to phacotrabeculectomy in terms of IOP reduction, with mean IOP reductions of − 26.1 mmHg and − 25.7 mmHg (P = 0.383), respectively, from baseline values of around 40 mmHg. Both groups experienced a significant reduction in the mean number of medications used postoperatively (P < 0.001). The cumulative success rate was comparable between the groups (P = 0.890). However, phacogoniotomy had a lower rate of postoperative complications and interventions (12.3% and 4.6%) compared to phacotrabeculectomy (23.7% and 20.3% respectively). The phacogoniotomy group reported shorter surgery time (22.1 ± 6.5 vs. 38.8 ± 11.1 min; P = 0.030) and higher quality of life (EQ-5D-5 L) improvement at 12 months (7.0 ± 11.5 vs. 3.0 ± 12.9, P = 0.010) than the phacotrabeculectomy group.
Conclusions
Phacogoniotomy was non-inferior to phacotrabeculectomy in terms of IOP reduction for advanced PACG and cataracts. Additionally, phacogoniotomy provided a shorter surgical time, lower postoperative complication rate, fewer postoperative interventions, and better postoperative quality of life.
{"title":"Phacogoniotomy versus phacotrabeculectomy for advanced primary angle-closure glaucoma with cataract: A randomized non-inferiority trial","authors":"Yunhe Song , Fengbin Lin , Aiguo Lv , Yao Zhang , Lan Lu , Lin Xie , Guangxian Tang , Huiping Yuan , Yangfan Yang , Jiangang Xu , Ping Lu , Meichun Xiao , Xiaomin Zhu , Xiaowei Yan , Wulian Song , Xiaoyan Li , Hengli Zhang , Fei Li , Zhenyu Wang , Ling Jin , Xiulan Zhang","doi":"10.1016/j.apjo.2023.100033","DOIUrl":"https://doi.org/10.1016/j.apjo.2023.100033","url":null,"abstract":"<div><h3>Purpose</h3><p>To investigate the effectiveness and safety of phacogoniotomy versus phacotrabeculectomy (PVP) among patients with advanced primary angle-closure glaucoma (PACG) and cataracts.</p></div><div><h3>Design</h3><p>Multicenter, randomized controlled, non-inferiority trial.</p></div><div><h3>Methods</h3><p>A total of 124 patients (124 eyes) with advanced PACG and cataracts were enrolled, with 65 in the phacogoniotomy group and 59 in the phacotrabeculectomy group. Patients were followed up for 12 months with standardized evaluations. The primary outcome was the reduction in intraocular pressure (IOP) from baseline to 12 months postoperatively, of which a non-inferiority margin of 4 mmHg was evaluated. Secondary outcomes included the cumulative surgical success rate, postoperative complications, and changes in the number of glaucoma medications.</p></div><div><h3>Results</h3><p>After 12 months, phacogoniotomy demonstrated non-inferiority to phacotrabeculectomy in terms of IOP reduction, with mean IOP reductions of − 26.1 mmHg and − 25.7 mmHg (P = 0.383), respectively, from baseline values of around 40 mmHg. Both groups experienced a significant reduction in the mean number of medications used postoperatively (P < 0.001). The cumulative success rate was comparable between the groups (P = 0.890). However, phacogoniotomy had a lower rate of postoperative complications and interventions (12.3% and 4.6%) compared to phacotrabeculectomy (23.7% and 20.3% respectively). The phacogoniotomy group reported shorter surgery time (22.1 ± 6.5 vs. 38.8 ± 11.1 min; P = 0.030) and higher quality of life (EQ-5D-5 L) improvement at 12 months (7.0 ± 11.5 vs. 3.0 ± 12.9, P = 0.010) than the phacotrabeculectomy group.</p></div><div><h3>Conclusions</h3><p>Phacogoniotomy was non-inferior to phacotrabeculectomy in terms of IOP reduction for advanced PACG and cataracts. Additionally, phacogoniotomy provided a shorter surgical time, lower postoperative complication rate, fewer postoperative interventions, and better postoperative quality of life.</p></div>","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2162098923002359/pdfft?md5=8906aa135ca9c0b293fcaacf1fbd771b&pid=1-s2.0-S2162098923002359-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139901546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-01DOI: 10.1016/j.apjo.2024.100035
Steven J. Fliesler
{"title":"The subretinal drusenoid deposit (SDD) of age-related macular degeneration (AMD) may have a specific and strong association with high-risk vascular diseases (HRVDs)","authors":"Steven J. Fliesler","doi":"10.1016/j.apjo.2024.100035","DOIUrl":"10.1016/j.apjo.2024.100035","url":null,"abstract":"","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2162098924000185/pdfft?md5=9d7019cf988d0f7204196a9509c501cb&pid=1-s2.0-S2162098924000185-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139466159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-01DOI: 10.1016/j.apjo.2024.100036
R. Theodore Smith , Timothy W. Olsen , Victor Chong , Judy Kim , Martin Hammer , Gareth Lema , Avnish Deobhakta , Anna Tan , Yuehong Tong , Katy Tai , Yang Fei , Emanuel Mordechaev , Gerardo Ledesma-Gil , Oscar Otero-Marquez , Richard B Rosen , Alauddin Bhuiyan , Sobha Sivaprasad , Philip J. Rosenfeld
Decades of studies on age-related macular degeneration (AMD), cardiovascular disease and stroke have not found consistent associations between AMD and systemic vascular disease. This study suggests that there is in fact no general relationship, but instead a strong, specific association between only the subretinal drusenoid deposit (SDD) phenotype of AMD on retinal imaging and certain co-existent vascular diseases that are high risk for compromised cardiac output or internal carotid artery stenosis. Future screening initiatives for these high -risk vascular diseases (HRVDs) with fast, inexpensive retinal imaging could make a significant contribution to public health and save lives. Likewise, screening patients with known HRVDs for unrecognized AMD of the SDD form could enable needed treatment and save vision.
{"title":"Subretinal drusenoid deposits, age-related macular degeneration, and cardiovascular disease","authors":"R. Theodore Smith , Timothy W. Olsen , Victor Chong , Judy Kim , Martin Hammer , Gareth Lema , Avnish Deobhakta , Anna Tan , Yuehong Tong , Katy Tai , Yang Fei , Emanuel Mordechaev , Gerardo Ledesma-Gil , Oscar Otero-Marquez , Richard B Rosen , Alauddin Bhuiyan , Sobha Sivaprasad , Philip J. Rosenfeld","doi":"10.1016/j.apjo.2024.100036","DOIUrl":"10.1016/j.apjo.2024.100036","url":null,"abstract":"<div><p>Decades of studies on age-related macular degeneration (AMD), cardiovascular disease and stroke have not found consistent associations between AMD and systemic vascular disease. This study suggests that there is in fact no general relationship, but instead a strong, specific association between only the subretinal drusenoid deposit (SDD) phenotype of AMD on retinal imaging and certain co-existent vascular diseases that are high risk for compromised cardiac output or internal carotid artery stenosis. Future screening initiatives for these high -risk vascular diseases (HRVDs) with fast, inexpensive retinal imaging could make a significant contribution to public health and save lives. Likewise, screening patients with known HRVDs for unrecognized AMD of the SDD form could enable needed treatment and save vision.</p></div>","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2162098924000197/pdfft?md5=c144f5027c9215045c6a30e28cc1caea&pid=1-s2.0-S2162098924000197-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139511703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-01DOI: 10.1016/j.apjo.2023.100031
Alexandra R. Zaloga, Charles DeYoung, Deepthi E. Kurian, Kevin R. Card, G. Brandon Caudill, Jennifer S. Zeiger, Carol L. Shields
Purpose
To determine the relationship between iris color and uveal melanoma (UM)-related metastasis and death in a large cohort of patients from a single ocular oncology center.
Design
Retrospective case series.
Subjects
Patients diagnosed with UM between February 1971 and August 2007.
Methods
Patient information was obtained from chart documentation.
Main outcome measures
UM-related metastasis and death.
Results
Out of 7245 patients, iris color was blue in 3702 (51%), green in 1458 (20%), and brown in 2085 (29%). Mean age was 58 ± 15 years and mean tumor thickness was 5.5 ± 3.3 millimeters. Some clinical features differed between iris color groups, with the blue irides group having a larger proportion of post-equatorial tumors with significantly closer proximity to the foveola and optic disc compared to the brown irides group. At a mean follow-up of 75 months, there was no statistically significant difference in metastasis between the various iris color groups. On univariate analysis, those with blue irides showed a higher incidence of UM-related death compared to the green and brown irides groups (8.3%, 5.9% and 7.5% respectively, p value = 0.02). Kaplan-Meier event free survival from UM-related death significantly differed only between the blue and green irides groups (p value = 0.007) with the green irides group showing the highest survival. However, on multivariate analysis, iris color was not predictive of UM-related death.
Conclusion
Iris color was not predictive of UM-related metastasis or death. However, Kaplan-Meier survival at 20 years was poorest for blue irides group compared to green.
{"title":"Impact of iris color on uveal melanoma-related outcomes in 7245 patients at a single ocular oncology center","authors":"Alexandra R. Zaloga, Charles DeYoung, Deepthi E. Kurian, Kevin R. Card, G. Brandon Caudill, Jennifer S. Zeiger, Carol L. Shields","doi":"10.1016/j.apjo.2023.100031","DOIUrl":"https://doi.org/10.1016/j.apjo.2023.100031","url":null,"abstract":"<div><h3>Purpose</h3><p>To determine the relationship between iris color and uveal melanoma (UM)-related metastasis and death in a large cohort of patients from a single ocular oncology center.</p></div><div><h3>Design</h3><p>Retrospective case series.</p></div><div><h3>Subjects</h3><p>Patients diagnosed with UM between February 1971 and August 2007.</p></div><div><h3>Methods</h3><p>Patient information was obtained from chart documentation.</p></div><div><h3>Main outcome measures</h3><p>UM-related metastasis and death.</p></div><div><h3>Results</h3><p>Out of 7245 patients, iris color was blue in 3702 (51%), green in 1458 (20%), and brown in 2085 (29%). Mean age was 58 ± 15 years and mean tumor thickness was 5.5 ± 3.3 millimeters. Some clinical features differed between iris color groups, with the blue irides group having a larger proportion of post-equatorial tumors with significantly closer proximity to the foveola and optic disc compared to the brown irides group. At a mean follow-up of 75 months, there was no statistically significant difference in metastasis between the various iris color groups. On univariate analysis, those with blue irides showed a higher incidence of UM-related death compared to the green and brown irides groups (8.3%, 5.9% and 7.5% respectively, <em>p</em> value = 0.02). Kaplan-Meier event free survival from UM-related death significantly differed only between the blue and green irides groups (<em>p</em> value = 0.007) with the green irides group showing the highest survival. However, on multivariate analysis, iris color was not predictive of UM-related death.</p></div><div><h3>Conclusion</h3><p>Iris color was not predictive of UM-related metastasis or death. However, Kaplan-Meier survival at 20 years was poorest for blue irides group compared to green.</p></div>","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2162098923000312/pdfft?md5=1eb8fe4d1fb10a8caae990563ff578e7&pid=1-s2.0-S2162098923000312-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139901562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}