Bangladesh Medical Research Council Bulletin最新文献

{"title":"Diagnostic value of serum adenosine deaminase in tuberculous lymphadenitis","authors":"M. Adhikari, S. M. Arafat, M. Ananna, Md. Atikur Rahman, H. Imam, Shah Mohammad Mohaimenul Haq","doi":"10.3329/bmrcb.v47i2.57773","DOIUrl":"https://doi.org/10.3329/bmrcb.v47i2.57773","url":null,"abstract":"Background: Extra-pulmonary tuberculosis often requires FNAC or biopsy of lymph node to reach a final diagnosis of tuberculous lymphadenitis, which is invasive, expensive, and needs an advanced setting. Estimation of adenosine deaminase (ADA) in different body fluid and serum has been suggested as a quick, cheap, and reliable test for tuberculosis.\u0000Objective: The study was intended to assess the usefulness of serum ADA in the diagnosis of tuberculous lymphadenitis.\u0000Methods: This was a cross-sectional observational study, conducted in BSMMU over a two year period and included 68 participants, divided equally into two group e.g. tuberculous lymphadenitis and a healthy comparison group. As tuberculous lymphadenitis, only newly diagnosed cases, labeled on the basis of histopathological findings of epithelioid granuloma with caseation necrosis were included. Serum ADA concentrations were estimated by enzymatic method and compared between groups.\u0000Results: The mean serum ADA concentration was found to be 25.52±7.11 U/L in tuberculous lymphadenitis group, which was significantly higher (p=0.000) than that of the healthy comparison group (14.82±3.85 U/L). Three different cut-off values of serum ADA (18.25 U/L, 20.45 U/L, 22.15 U/L) were used to determine the best predictive value for the diagnosis of tuberculous lymphadenitis. Sensitivity and specificity of these cut off values were 91.2% and 82.4%, 79.4% and 88.2%, 67.6% and 97.1% respectively.\u0000Conclusion: It is clearly denoted by the study that, tuberculous lymphadenitis patients has significant higher serum ADA then the healthy comparison group. This result indicates that serum ADA can be used as a useful adjunct in the diagnosis of tuberculous lymphadenitis with conventional investigations.\u0000Bangladesh Med Res Counc Bull 2021; 47(2): 151-155","PeriodicalId":8704,"journal":{"name":"Bangladesh Medical Research Council Bulletin","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42415056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intra-articular Injection of Hyaluronic Acid (HA) and Plateletrich Plasma (PRP) in the Treatment of Mild and Moderate Osteoarthritis of Knee","authors":"Farzana Khan Shoma, Z. Chowdhury, F. Hossain, Abul Khair Mohammad Salek, M. Khasru, Md. Nuruzzaman Khandaker","doi":"10.3329/bmrcb.v47i1.55800","DOIUrl":"https://doi.org/10.3329/bmrcb.v47i1.55800","url":null,"abstract":"Background: Osteoarthritis (OA) is the most prevalent chronic joint disorder worldwide and is associated with significant pain and disability. Introduction of platelet-rich plasma (PRP) injection has been viewed as an advance in the management of OA knee.\u0000Objective: To compare the effectiveness of PRP and Hyaluronic Acid (HA) in the treatment of mild and moderate OA knee\u0000Methods: The present randomized clinical trial had been conducted in the Department of Physical Medicine and Rehabilitation, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka from 2018 to 2019. A total of 154 patients with mild and moderate OA knee were randomly allocated into two groups: group A (received PRP injection) and group B (received HA injection) where 133 patients completed the follow-up schedule. Outcomes were measured by OA specific translated and validated Bengali instrument- Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) questionnaire and visual analogue scale (VAS 0-10). They were followed-up for 6 months.\u0000Results: There was no significant statistical difference at the baseline between the groups regarding age, sex, grading of OA knee, side involvement, mean duration of the disease, VAS scores and WOMAC scores. After one month, VAS score significantly decreased in PRP group compared to HA group (p<0.001). However, there was no statistical difference regarding total WOMAC scores between two groups (p=0.063). In third and sixth month, VAS score significantly decreased in PRP group compared to HA group (p<0.001). Though the stiffness and physical activity scores of WOMAC did not reduce significantly, the pain score reduced significantly in PRP group compared to HA group. In both groups, significant reduction of VAS and WOMAC total scores was observed after six months follow-up compared to baseline values (p<0.001).\u0000Conclusion: Intra-articular platelet-rich plasma improves pain and function of the knee in patients with osteoarthritis. Though intra-articular hyaluronic acid also improves pain and function in the foot, PRP is more effective than hyaluronic acid. Multi-centered clinical trial with long term follow-up should be conducted to see the effects of PRP and HA.\u0000Bangladesh Med Res Counc Bull 2021; 47(1): 62-69","PeriodicalId":8704,"journal":{"name":"Bangladesh Medical Research Council Bulletin","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48346216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insulin Resistance in Obese Adolescents at a Tertiary care hospital in Bangladesh","authors":"Roksana Parvin, Suraiya Begum, Abul Basher Md. Osman Hayder Mazumder, I. Jahan, K. J. Shyamaly","doi":"10.3329/bmrcb.v47i2.57782","DOIUrl":"https://doi.org/10.3329/bmrcb.v47i2.57782","url":null,"abstract":"Background: Insulin resistance has evolved as an important metabolic alteration in obese children especially during adolescence. Emerging data suggest that insulin resistance in obesity play the key role in the pathogenesis of hypertension, dyslipidemia, impaired glucose tolerance, type 2 diabetes mellitus, non-alcoholic fatty liver disease and metabolic syndrome. Objective: The aim of this study was to assess the insulin resistance status of Bangladeshi obese adolescents in hospital settings. Methods: It was a cross sectional study done in children, aged 10 to 16 years, attending the paediatric endocrine clinic, paediatric outpatient and paediatric inpatient department, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka over a period of 15 months. Homeostasis Model Assessment of Insulin Resistance (HOMA- IR) value was obtained from fasting insulin & fasting blood glucose level to assess insulin resistance in obese and normal weight children. Results: Among obese adolescents, 78.8% were insulin resistant in comparison to16% in non-obese adolescent. Mean HOMA-IR level of obese group were significantly higher than non-obese group (4.46±1.82 Vs 1.98±1.26, p<0.001). Insulin resistance was observed in 73.8% and 84.2% among grade 1 obese and grade 2 obese adolescents respectively. HOMA-IR showed positive correlation with BMI and waist circumference. Insulin resistance showed significant association with central obesity, puberty and acanthosis nigricans (AN). Conclusion: In this study, insulin resistance was observed in higher frequency among obese adolescents than normal weight adolescents. Obese adolescents with central obesity, acanthosis nigricans and puberty are at increased risk of insulin resistance. Bangladesh Med Res Counc Bull 2021; 47(2): 212-218","PeriodicalId":8704,"journal":{"name":"Bangladesh Medical Research Council Bulletin","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48936021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Under-five Nutritional Status and its Relationship with Household Dietary Diversity and Food Security among the Dayak Communities in Sarawak, Malaysia","authors":"Md. Mizanur Rahman, Neilson Richard Seling, A. Kiyu","doi":"10.3329/bmrcb.v47i2.57770","DOIUrl":"https://doi.org/10.3329/bmrcb.v47i2.57770","url":null,"abstract":"Background: Malnutrition among under-five children is one of the paramount public health concerns in the country.\u0000Objectives: This study aimed to determine the relationship between under-five nutritional status and household dietary diversity (HDD) and household food security (HFS).\u0000Methods: In this cross-sectional study analysed 808 under-five children’s data from 50 villages in five divisions of Sarawak using a multistage cluster sampling technique. Data were collected by face-to-face interview using interviewer-administered questionnaires. WHO Anthro version 3.2.2 was used for anthropometric, and IBM SPSS version 22.0 was used for multivariate data analysis.\u0000Results: Multivariate analysis showed that children with low HDD were 1.68 times more likely to be stunted than those with high HDD. Children from households with food insecurity but without hunger were 3.86 times and with hunger were 4.02 times likely to be wasted in the last three months and were almost six times more likely to stunted at the same time. The likelihood of being underweight was 2.86 times more likely to occur in households with food insecurity without hunger and 4.89 times in food insecurity with hunger households. In the past 12 months, children from households with food insecurity with hunger were 8.56 times and four times more likely to be stunted with food insecurity without hunger. Underweight children had twice the odds of occurring in households with food insecurity without hunger compared with food secured households. HFS in the last three months had a significant association with wasting, stunting and underweight of the children, while HFS in the last 12 months was associated with stunting and underweight children.\u0000Conclusion: Low HDD had resulted in stunting, and food insecurity had resulted in wasting, stunting and underweight in under-five Dayak children in rural areas of Sarawak. A food-based intervention programme should be undertaken for malnourished children.\u0000Bangladesh Med Res Counc Bull 2021; 47(2): 127-135","PeriodicalId":8704,"journal":{"name":"Bangladesh Medical Research Council Bulletin","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46606331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mind-set of Recent Medical Graduates: A Channel for Teaching Medical Ethics and Professionalism in Bangladesh","authors":"S. Jahan, M. Flora","doi":"10.3329/bmrcb.v47i1.55801","DOIUrl":"https://doi.org/10.3329/bmrcb.v47i1.55801","url":null,"abstract":"Background: The medical ethics and professionalism teaching have an influence on knowledge, attitude and skills of physicians. The scope of learning medical ethics and professionalism is limited in Curriculum for Medical Education in Bangladesh. There is an unhealthy situation in physician-patient relationship as a consequence of this limitation.\u0000Objectives: This study was aimed to assess attitude of recent medical graduates towards medical ethics and professionalism. The findings of this study might be helpful to strengthen medical ethics and professionalism in the medical education.\u0000Methods: This descriptive study was conducted on recent medical graduates of seven medical colleges under four universities in Bangladesh from January 2018 to June 2019. Data were collected using a pretested self administered semi-structured questionnaire, based on attitude measuring scale regarding medical ethics and professionalism.\u0000Results: Attitude scores of 308 recent medical graduates were in ethical conduct, autonomy, information of wrong doing during treatment, confidentiality, informed consent, sharing the condition of patient to close relatives, paternalism, treating of violent patient, abortion, euthanasia, religious beliefs influencing the choice of treatment, physician-patient relationship, informed decision making, continued medical education and role of pharmaceutical representative were assessed. The average scores were ranging from 2.1 to 4.2; with maximum clustering around score ‘3’ or “not sure”. Majority of the study population thought that the current standard of ethics practice was lower than expectation (59.1%) and should give more attention (76.6%) than the present. Furthermore, most of them (85.4%) felt a need for a separate module on medical ethics and professionalism in undergraduate medical curriculum.\u0000Conclusion: The recent medical graduates showed a positive attitude towards medical ethics and professionalism. So, a favourable environment was observed for learning medical ethics and professionalism. Thus, to strengthening of medical ethics and professionalism in medical education curricula is suggested.\u0000Bangladesh Med Res Counc Bull 2021; 47(1): 57-61","PeriodicalId":8704,"journal":{"name":"Bangladesh Medical Research Council Bulletin","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47643270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the diagnosis Delay Among Breast Cancer Patients Attending in a Tertiary Care Hospital in Dhaka","authors":"K. Akhtar, K. Hossain, S. Nahar, K. Akhtar","doi":"10.3329/bmrcb.v47i2.57771","DOIUrl":"https://doi.org/10.3329/bmrcb.v47i2.57771","url":null,"abstract":"Background: Diagnosis is a key determinant for any disease outcome. For that, we want to find out in which stage a breast cancer patient got admitted in hospital including various methods of laboratory investigations were done at different visits.\u0000Objectives: This study was aimed to generate information on the stages that a breast cancer patient got admitted including various methods of laboratory investigations were done at different visits.\u0000Methodology:   We conducted a cross sectional study at the National Institute of Cancer Research and Hospital, Dhaka, Bangladesh from July 2017-June 2018. We randomly selected a total of 200 patients who came to that hospital through face-to-face interview by using pretested semi-structured questionnaire.\u0000Results: A total 77.0% (154) patients investigated Fine Needle Aspiration Cytology (FNAC) at first visit and mean duration for diagnosis was 11 months. Maximum patients came for diagnosis at stage II, III or IV; nobody came at stage I. As consequences, we found that stage of cancer had 7 times more likely to cause diagnostic delay (OR=7.957; 95% CI 3.206-19.749) p <0.0001. Number of consultations was one of the cause for diagnostic delay (c2= 12.825, p <0.0001). Diagnostic delay had strong association between first consultation with physician versus other health care providers (c2= 17.645, p <0.0001). Excluding physicians, first consultation with health care providers also had 3 times more likely to cause delay in diagnosis (OR-3.862; 95% CI1.877-7.944) p<0.0001.\u0000Conclusion: Breast cancer patients attended to health care provider at advanced stage. Knowledge, negative perception, social support were the contributing factor for delay in breast cancer diagnosis.\u0000Bangladesh Med Res Counc Bull 2021; 47(2): 136-142","PeriodicalId":8704,"journal":{"name":"Bangladesh Medical Research Council Bulletin","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48711734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frequency of G-Globin Promoter -158(C>T) Xmnl polymorphism and its correlation with Beta thalassaemia mutations in Bangladeshi population","authors":"Waqar A Khan, B. Banu, Md. Abdul Aziz, S. Sadiya, Md. Belayet Hossain, M. Selimuzzaman","doi":"10.3329/bmrcb.v47i2.57783","DOIUrl":"https://doi.org/10.3329/bmrcb.v47i2.57783","url":null,"abstract":"Background: In Bangladesh, more than 14000 children on are born annually with in thalassaemia – a common congenital disease Hb E trait is 6.1%. Hb E beta thalassaemia is the most common type of thalassaemia, followed by Beta thalassaemia major.\u0000Objectives: To determine the frequency of Xmn1 polymorphism and its association with Beta thalassaemia mutations.\u0000Methods: A total of one hundred and four Bangladeshi thalassaemia patients were analysed. Amplification Refractory Mutation System (ARMS) was utilized for Beta thalassaemia mutations and digestion of the PCR product using Xmn1 restriction enzyme Pdml for Xmn1 polymorphism.\u0000Results: Xmn1 polymorphism was detected in seventy patients of which 60(57.69%) were heterozygous for Xmn1 polymorphism and seventeen (16.35%) were homozygous. The most common genotype found was heterozygous Xmn1(-/+)seen in 57.70%. The age of presentation of thalassaemic patients was delayed in those who had Xm1 polymorphism.The mean age of presentation of Hb E beta thalassaemia was 13.35 years having homozygous Xm1 polymorphism,7.21 years in heterozygous and 6.25 years without Xmn 1 polymorphism. The most common mutation detected was Cd26 (G-A) +IVS 1-5(G-C) in fifty eight patients in which thirty nine (67.24%) were heterozygous for Xmn 1 polymorphism and 8 (13.79%) were homozygous (+/+).The second most common mutation observed was Cd26(G-A)+30(G-C) seen in fourteen patients where 57.14% were homozygous for Xmn 1 polymorphism and 35.71% were heterozygous. In thalassaemia major 9 (90%) were negative for Xmn1 polymorphism. Allele frequency of Xmn 1 polymorphism was 0.45.\u0000Conclusion: The association of Xmn1 polymorphism with two common mutations seen in Hb E beta thalassemia patients may be utilized for hydroxyurea therapy to reduce the requirement of blood transfusion.\u0000Bangladesh Med Res Counc Bull 2021; 47(2): 219-224","PeriodicalId":8704,"journal":{"name":"Bangladesh Medical Research Council Bulletin","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46100267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low Birth Weight Baby and Its Associated Factors among Rural Women in Bangladesh: A Decision Curve Analysis","authors":"M. G. Uddin, M. S. Islam, M. I. H. Methun","doi":"10.3329/bmrcb.v47i1.55798","DOIUrl":"https://doi.org/10.3329/bmrcb.v47i1.55798","url":null,"abstract":"Background: Low birth weight is considered to be one of the main risk factors for infant mortality and morbidity. It is associated with a range of both short- and long-term consequences.\u0000Objectives: The study examined the factors contributing to low birth weight of the baby in Bangladesh. This study also attempted with the objective of ensuing a prediction of low birth weight.\u0000Methods: The study was a case-control quantitative survey. A three-stage cluster sample design was used to conduct the survey. A total of 674 (337 cases and 337 control) mothers/care givers of under 1 year children were selected from 2 districts of Bangladesh. Binary logistic regression and decision curve analysis were used to investigate the factors which attribute to low birth weight baby born.\u0000Results: The findings of the study revealed that mean birth weight was 2.1±0.4 kg among low birth weight children whereas it was 3.0±0.5 kg for normal birth weight children. The mean age of sampled mothers was 25.2±5.4 years. Every 2 in 3 mage got married before 18 years. The prevalence of low birth weight baby among the women with secondary or higher education was lower (47.4%) compared to the women no formal education (65.4%). Analysis revealed that several socio-demographic factors like parental education level, maternal age at first marriage, working status were significantly associated with low birth weight of the baby (p<0.05). Some biological and medical factors like multiple births, maturity of the birth, prenatal care and taking iron and folic acid during pregnancy were also significantly associated with low birth weight baby born. Finally, decision curve analysis technique predicted a net benefit of 0.3907 for the profitable model with highest number of factors. This result implies that the fitted model can predict 39% low birth weight based on independent factors.\u0000Conclusion: Prediction model indicates that parental and biological factors are caused for low birth weight baby born in rural areas. Maternal and child health program should focus behavioural change regarding create awareness of disadvantage of early marriage, intake IFA supplementation, at least 4 ANC visit to reduce low birth weight baby born.\u0000Bangladesh Med Res Counc Bull 2021; 47(1): 42-49","PeriodicalId":8704,"journal":{"name":"Bangladesh Medical Research Council Bulletin","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46988586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ESBL Genes, blaTEM, blaOXA, and blaSHV in Poultry Gut Bacteria: An Endemic Public Health Burden in Bangladesh","authors":"S. Nahar, U. Urmi, T. Ali, Adity Rumnaz, T. A. Haque, B. Ara, Mohammed Shah Alam, Abu Syed Md. Mosaddek, Salequl Islam","doi":"10.3329/bmrcb.v47i2.57775","DOIUrl":"https://doi.org/10.3329/bmrcb.v47i2.57775","url":null,"abstract":"Background: In Bangladesh, the poultry industry contributes a significant role in the food sector. A vast amount of antibiotic is used as prophylaxis and growth promotion factors in farms. These unconcerned uses of antibiotics ultimately generate resistant bacteria affecting substantial adverse consequences on human health. Extended-spectrum b-lactamase (ESBL) genes are responsible for inactivation of antibiotics containing b-lactam ring, namely, penicillin, cephalosporins, monobactams, and carbapenems.\u0000Objectives: This study was designed to analyse the distribution of three ESBL genes and associated antimicrobial susceptibility profile of poultry gut bacteria.\u0000Methods: This study was designed to analsze the distribution of three ESBL genes and associated antimicrobial susceptibility profile of poultry gut bacteria. Poultry feces were collected and cultured on cysteine lactose electrolyte deficient (CLED) agar and Salmonella-Shigella (SS) agar to differentiate various isolates based on colony characteristics. Identification of the isolates was made by convention biochemical tests, analytical profile index (API-20E), and 16S rRNA sequence analysis. Antibiotic susceptibility test was done by disc diffusion method using 17 antibiotics from seven groups. Subsequently, polymerase chain reaction (PCR) was employed with a specific primer to identify respective ESBL genes (blaTEM, blaSHV, blaOXA). All data were analysed by SPSS.\u0000Results: A total of 113 isolates were identified from 85 poultry feces tested. Most of the bacteria belonged to Enterobacteriaceae family, notably Proteus spp., E. coli, Klebsiella spp., Salmonella spp., and Enterobacter spp. Different bacteria were detected, namely, Kurthia populi, Cronobactersp, and Eikenella corrodens.   Most of the poultry isolates were resistant against more than one group of antibiotics. ESBL gene, blaTEM gene was identified most frequently (53.9%), followed by blaOXA (52.2%), and blaSHV (23%). Higher phenotypic resistance was observed in isolates carrying ESBL genes.\u0000Conclusion: This study revealed a very high frequency of three ESBL genes with their phenotypic resistance- capacities in Bangladeshi poultry gut microbiota. Excess uses of antibiotics in local poultry farms may result in the emergence of antibiotic resistance that is imposing public health threatening in Bangladesh.\u0000Bangladesh Med Res Counc Bull 2021; 47(2): 165-174","PeriodicalId":8704,"journal":{"name":"Bangladesh Medical Research Council Bulletin","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47336926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasonographic assessment of dengue fever and its correlation with platelet count","authors":"K. Nahar, M. Jahan, S. Akhter, Saikat Barua, D. Begum, M. Hasan","doi":"10.3329/bmrcb.v47i1.55794","DOIUrl":"https://doi.org/10.3329/bmrcb.v47i1.55794","url":null,"abstract":"Background: Dengue virus infections are a significant threat to human populations particularly in the tropical and subtropical regions. This is mainly transmitted by Aedes aegypti mosquito from humans to humans. The main pathological mechanisms associated include thrombocytopenia, haemorrhagic diathesis with haemoconcentration. Ultrasonography is used because of its ability to detect plasma leakage signs and prediction of disease severity. Objective: To evaluate the usefulness of ultrasonographic findings of dengue fever and its correlation with platelet count. Methods: It was a prospective observational study, carried out in Bangladesh Medical College Hospital, Dhaka from May 2019 to August 2019. A total of 213 patients of suspected dengue fever during the epidemic were included in this study. All the cases were serologically diagnosed and evaluated with ultrasonographic findings. Platelet counts were estimated in all the cases and compared with findings recorded on ultrasonographic findings. Results: The mean age of the study population was 28.7 years. The male female ratio was 1.7:1. The common features on ultrasonography were thickened and oedematous gall bladder wall, mild to moderate ascites, pleural effusion (unilateral and bilateral), and hepatosplenomegaly. Thickened and oedematous gall bladder wall were observed in 68.8%, mild to moderate ascites 65.3%, bilateral pleural effusion 58.2 %, unilateral pleural effusion 40.4%, hepatomegaly 34.3 % and splenomegaly 13.6 % Platelet counts were significantly lower in abnormal ultrasonographic findings (p=0.001). Conclusion: In a febrile patient with thrombocytopenia and positive dengue serology, ultrasonography of the abdomen is a useful tool to evaluate the severity of illness. Ultrasound findings of gall bladder wall oedema, ascites, and pleural effusion were correlated with the severity of thrombocytopenia. In epidemic scenarios, Ultrasonographic features may help in roughly estimating the platelet count even before serology and platelet results are available. Thus, it helps in treatment planning without waiting for the laboratory results. Bangladesh Med Res Counc Bull 2021; 47(1): 23-28","PeriodicalId":8704,"journal":{"name":"Bangladesh Medical Research Council Bulletin","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44328413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}