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Apamarga Ksharasutra application and open lateral internal sphincterotomy in the management of Parikartika (chronic fissure‑in‑ano): A randomized controlled clinical trial. 应用Apamarga Ksharasutra和开放外侧内括约肌切开术治疗慢性骨裂:一项随机对照临床试验。
Ayu
Pub Date : 2019-07-01 Epub Date: 2020-08-08 DOI: 10.4103/ayu.AYU_144_18
Hetal L Nakrani, Tukaram Sambhaji Dudhamal

Introduction: Parikartika resembles fissure‑in‑ano which is one of the common painful disease among the anorectal disorders. Ksharasutra which is a para‑surgical procedure is effective in the management of Parikartika.

Aim: To compare the efficacy of Apamarga Ksharasutra and open lateral internal sphincterotomy (OLIS) in the management of Parikartika (chronic fissure‑in‑ano).

Materials and methods: Total 30 patients having signs and symptoms of Parikartika (chronic fissure‑in‑ano) were selected and randomly divided into two groups. In Group A (n = 15), Ksharasutra ligation after anal stretching was carried out while in Group B (n = 15), OLIS with excision of skin tag was carried out under local anesthesia or spinal anesthesia. Relief in postoperative symptoms and complications if any was recorded for 4 weeks and follow‑up was done for the period of 1 month.

Results: In both the groups, significant results were obtained, but the difference among groups was statistically insignificant. Duration required for relief in postoperative pain, bleeding, swelling, and wound healing was found to be more in Group A (Ksharasutra) than Group B (OLIS).

Conclusion: OLIS provided better results compared to Ksharasutra ligation in the management of Parikartika (chronic fissure‑in‑ano).

简介:Parikartika类似于肛瘘,是肛肠疾病中常见的疼痛性疾病之一。Ksharasutra是一种准外科手术,在治疗Parikartika方面是有效的。目的:比较Apamarga Ksharasutra与开放外侧内括约肌切开术(OLIS)治疗慢性骨裂(Parikartika)的疗效。材料和方法:选择30例有慢性骨裂(Parikartika)体征和症状的患者,随机分为两组。A组(n = 15)在肛门拉伸后行Ksharasutra结扎术;B组(n = 15)在局麻或脊髓麻醉下行OLIS合并皮赘切除术。术后症状和并发症(如有)的缓解记录持续4周,随访1个月。结果:两组疗效均显著,但组间差异无统计学意义。缓解术后疼痛、出血、肿胀和伤口愈合所需的时间,A组(Ksharasutra)比B组(OLIS)更长。结论:OLIS在治疗慢性骨裂(Parikartika)方面比Ksharasutra结扎有更好的效果。
{"title":"<i>Apamarga</i> <i>Ksharasutra</i> application and open lateral internal sphincterotomy in the management of <i>Parikartika</i> (chronic fissure‑in‑ano): A randomized controlled clinical trial.","authors":"Hetal L Nakrani,&nbsp;Tukaram Sambhaji Dudhamal","doi":"10.4103/ayu.AYU_144_18","DOIUrl":"https://doi.org/10.4103/ayu.AYU_144_18","url":null,"abstract":"<p><strong>Introduction: </strong><i>Parikartika</i> resembles fissure‑in‑ano which is one of the common painful disease among the anorectal disorders. <i>Ksharasutra</i> which is a para‑surgical procedure is effective in the management of <i>Parikartika</i>.</p><p><strong>Aim: </strong>To compare the efficacy of <i>Apamarga Ksharasutra</i> and open lateral internal sphincterotomy (OLIS) in the management of <i>Parikartika</i> (chronic fissure‑in‑ano).</p><p><strong>Materials and methods: </strong>Total 30 patients having signs and symptoms of <i>Parikartika</i> (chronic fissure‑in‑ano) were selected and randomly divided into two groups. In Group A (<i>n</i> = 15), <i>Ksharasutra</i> ligation after anal stretching was carried out while in Group B (<i>n</i> = 15), OLIS with excision of skin tag was carried out under local anesthesia or spinal anesthesia. Relief in postoperative symptoms and complications if any was recorded for 4 weeks and follow‑up was done for the period of 1 month.</p><p><strong>Results: </strong>In both the groups, significant results were obtained, but the difference among groups was statistically insignificant. Duration required for relief in postoperative pain, bleeding, swelling, and wound healing was found to be more in Group A (<i>Ksharasutra</i>) than Group B (OLIS).</p><p><strong>Conclusion: </strong>OLIS provided better results compared to <i>Ksharasutra</i> ligation in the management of <i>Parikartika</i> (chronic fissure‑in‑ano).</p>","PeriodicalId":8720,"journal":{"name":"Ayu","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/76/d4/AYU-40-164.PMC7685256.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38689822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Evaluation of effect of poultice (Upanaha Sweda) in low back pain (Katigraha): A randomized comparative clinical trial. 评价药膏(Upanaha Sweda)治疗腰痛(Katigraha)的效果:一项随机对照临床试验。
Ayu
Pub Date : 2019-07-01 Epub Date: 2020-08-08 DOI: 10.4103/ayu.AYU_71_18
Tarun Kumar, Rajashekhar V Sanapeti, B S Prasad

Background: Katigraha (low back pain) is a condition where low back is afflicted either with Vata or Sama Vata (Vata involved with the toxins released due to altered digestion and metabolism) and present with symptoms such as pain with stiffness. About 60%-80% population in India suffer from this condition. Upanaha Sweda (poultice) is one of the Swedana (sudation) treatment modalities mentioned for Katigraha. As Sama (affected with toxins released from impaired digestion) and Nirama (without toxins) are two stages of Katigraha, hence, the specific type of Upanaha is required for such condition.

Aims and objective: The study was conducted to evaluate the effect of Upanaha Sweda in Katigraha (low back pain) as per the presentation of stages of Ama.

Materials and methods: Selected patients were categorized into two groups. In group A, patients having Samaja Katigraha, were given Panchakoladi Upanaha once a day till it became Niramaja, then shifted to Godhumadi Upanaha for 7 days and patients who had Niramaja Katigraha, Godhumadi Upanaha was used once a day for 7 days. In group B Godhumadi Upanaha was used once a day for 7 days irrespective of stages. Subjective parameters assessed were pain in the low back, stiffness, and Oswestry Disability Index (ODI) was also used. The Mann-Whitney U test and Wilcoxon signed‑rank test were used to assess results.

Results: Patients who were treated considering the Sama and Nirama phases had 78.88% better results in relieving pain, stiffness, and in ODI change than the patients treated without considering the phases.

Conclusion: The present study showed significant results in both the groups, but patients treated as per stage wise treatment showed better effect in treating Katigraha than the patients treated with out considering the stage.

背景:Katigraha(腰痛)是腰背部受到Vata或Sama Vata (Vata涉及由于消化和代谢改变而释放的毒素)的折磨,并表现为疼痛和僵硬等症状。大约60%-80%的印度人患有这种疾病。Upanaha Sweda(膏药)是提到的Katigraha的瑞典(汗)治疗方式之一。由于Sama(受消化受损释放的毒素影响)和Nirama(无毒素)是Katigraha的两个阶段,因此,这种情况需要特殊类型的Upanaha。目的和目的:本研究的目的是评估Upanaha Sweda在Katigraha(腰痛)中的作用,根据Ama的表现阶段。材料与方法:选取的患者分为两组。在A组,Samaja Katigraha患者,每天给予Panchakoladi Upanaha 1次,直到它成为Niramaja,然后转移到Godhumadi Upanaha 7天,Niramaja Katigraha患者,Godhumadi Upanaha每天1次,持续7天。B组无分期,每天1次,连用7天。主观参数评估为腰痛、僵硬,并使用Oswestry残疾指数(ODI)。采用Mann-Whitney U检验和Wilcoxon符号秩检验对结果进行评估。结果:考虑Sama和Nirama分期治疗的患者在缓解疼痛、僵硬和ODI变化方面的效果比不考虑分期治疗的患者好78.88%。结论:本研究两组疗效均显著,但按分期治疗的患者治疗Katigraha的效果优于不按分期治疗的患者。
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引用次数: 0
Clinical study of Arogyavardhini compound and lifestyle modification in management of metabolic syndrome: A double‑blind placebo controlled randomized clinical trial. Arogyavardhini和生活方式改变治疗代谢综合征的临床研究:一项双盲安慰剂对照随机临床试验
Ayu
Pub Date : 2019-07-01 Epub Date: 2020-08-08 DOI: 10.4103/ayu.AYU_79_19
Bharatkumar Chhaganbhai Padhar, Alankruta R Dave, Mandip Goyal

Background: Metabolic syndrome (MS) is a cluster of obesity, hypertriglyceridemia, impaired glucose tolerance, and insulin resistance. The sedentary lifestyle settles on the phenotypical expression of a genetically acquired trait in an obese person. Weight control and a healthy lifestyle remain primary and effective strategies for prevention and management of the MS. The lifestyle modifications mentioned for Santarpanjanya (disorders due to over nutrition) diseases and Arogyavardhini compound that can improve metabolism and reduce weight were selected for a present clinical trial to assess and compare their efficacy in the management of the MS.

Materials and methods: Seventy‑five patients were registered for the trial and randomly divided into two groups. Patients were treated with lifestyle modification with and without Arogyavardhini compound for 8 weeks.

Results: Thirty‑five patients in each group could complete the course of treatment. Lifestyle modification alone and with Arogyavardhini compound resulted in 1.32% and 3.06% decrease in waist circumference, 5.81% and 18.03% decrease in serum triglycerides, 4.43% and 6.89% decrease in systolic blood pressure, 3.82% increase and 2.48% decrease in fasting blood sugar, 9.13% and 5.56% increase in high‑density lipoprotein, respectively. The decrease in waist circumference, systolic blood pressure was statistically significant in the both groups.

Conclusion: Arogyavardhini compound, along with lifestyle modification was found more effective than lifestyle modification alone in the management of MS.

背景:代谢综合征(MS)是一组肥胖、高甘油三酯血症、糖耐量受损和胰岛素抵抗。久坐不动的生活方式决定了肥胖者基因获得性特征的表型表达。控制体重和健康的生活方式仍然是预防和管理多发性硬化症的主要和有效的策略。本临床试验选择了Santarpanjanya(由于营养过度引起的失调)疾病的生活方式改变和Arogyavardhini化合物,以评估和比较它们在多发性硬化症管理中的疗效。75名患者登记参加试验,并随机分为两组。患者分别接受8周的生活方式改变治疗,其中包括Arogyavardhini化合物。结果:每组35例患者均能完成疗程。生活方式改变组和Arogyavardhini组腰围分别下降1.32%和3.06%,血清甘油三酯分别下降5.81%和18.03%,收缩压分别下降4.43%和6.89%,空腹血糖分别升高3.82%和2.48%,高密度脂蛋白分别升高9.13%和5.56%。两组患者的腰围、收缩压下降均有统计学意义。结论:复方Arogyavardhini联合生活方式改变治疗MS比单独改变生活方式更有效。
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引用次数: 3
An overview of primary registries of WHO's international clinical trial registry platform. 世卫组织国际临床试验注册平台主要注册机构概述。
Ayu
Pub Date : 2019-07-01 Epub Date: 2020-08-08 DOI: 10.4103/ayu.AYU_62_20
Atul Juneja, Jyotsna Gupta, Neha Yadav, Saurabh Sharma, Yashmin Panchal, Tulsi Adhikari, M Vishnu Vardhana Rao

Introduction: WHO's International Clinical Trials Registry Platform (ICTRP) has 17 primary registries that collect the information on the minimum set of items of trial information that appear in the register and these registries are also endorsed by the International Committee of Medical Journal Editors.

Objective: The objective of this study is to describe the profile of all the primary registries including Clinical Trial Registry‑India (CTRI), through features such as magnitude, domain of registration, flagging, audit trail, language, mandatory requirements, and result disclosure.

Methodology: The profiling of all registries was based on countries and zones, year of establishment, registrant, flagging, conflict of interest, language, documents, result disclosure, type of study, mode of registration, mandate of registration, quality check method, individual patient data statement and translation of content facility. The mode of search used was online which included advanced search, basic search and also from the audio/video manual on their website.

Results: There are 17 primary registries of ICTRP, the first one International Standard Randomised Controlled Trial Number (ISRCTN) of England being initiated in year 2000 and the most recent being Lebanese registry, in September 2019. The trials registered with these registries range from 301 in Cuba to 53972 in European union's EU Clinical Trials Register. The primary registries in WHO registry network are diverse in functionalities and practices. The characteristics of online registers vary in content and features and to achieve coordinated level of data quality, across all the different registries and to keep a balance in standards of the data collected and validation of that data, the registries are adhering to the minimum data set items laid down by ICTRP.

Conclusion: The very process of registering the clinical studies helps in promoting the research methods and also raising the standards of research, especially among young researchers. It also helps in reducing the duplicity of research.

世卫组织的国际临床试验注册平台(ICTRP)有17个主要注册中心,收集出现在注册中心的最少试验信息项目集的信息,这些注册中心也得到国际医学杂志编辑委员会的认可。目的:本研究的目的是通过规模、注册领域、标记、审计跟踪、语言、强制性要求和结果披露等特征,描述包括印度临床试验注册中心(CTRI)在内的所有主要注册中心的概况。方法:对所有注册中心的分析是基于国家和地区、建立年份、注册人、标记、利益冲突、语言、文件、结果披露、研究类型、注册模式、注册授权、质量检查方法、个体患者数据声明和内容设施的翻译。使用的搜索模式是在线搜索,包括高级搜索,基本搜索以及他们网站上的音频/视频手册。结果:ICTRP有17个主要注册中心,英国的第一个国际标准随机对照试验号(ISRCTN)于2000年启动,最近的一个是黎巴嫩注册中心,于2019年9月启动。在这些注册中心注册的试验从古巴的301项到欧盟临床试验注册中心的53972项不等。世卫组织注册网络中的主要注册中心在功能和做法上各不相同。联机登记册的特点在内容和特征上各不相同,为了在所有不同的登记册之间实现数据质量的协调水平,并在收集数据的标准和数据的验证方面保持平衡,各登记册都遵守ICTRP规定的最低数据集项目。结论:临床研究注册的过程有助于推广研究方法,提高研究水平,特别是对年轻研究人员。它还有助于减少研究的口是心非。
{"title":"An overview of primary registries of WHO's international clinical trial registry platform.","authors":"Atul Juneja,&nbsp;Jyotsna Gupta,&nbsp;Neha Yadav,&nbsp;Saurabh Sharma,&nbsp;Yashmin Panchal,&nbsp;Tulsi Adhikari,&nbsp;M Vishnu Vardhana Rao","doi":"10.4103/ayu.AYU_62_20","DOIUrl":"https://doi.org/10.4103/ayu.AYU_62_20","url":null,"abstract":"<p><strong>Introduction: </strong>WHO's International Clinical Trials Registry Platform (ICTRP) has 17 primary registries that collect the information on the minimum set of items of trial information that appear in the register and these registries are also endorsed by the International Committee of Medical Journal Editors.</p><p><strong>Objective: </strong>The objective of this study is to describe the profile of all the primary registries including Clinical Trial Registry‑India (CTRI), through features such as magnitude, domain of registration, flagging, audit trail, language, mandatory requirements, and result disclosure.</p><p><strong>Methodology: </strong>The profiling of all registries was based on countries and zones, year of establishment, registrant, flagging, conflict of interest, language, documents, result disclosure, type of study, mode of registration, mandate of registration, quality check method, individual patient data statement and translation of content facility. The mode of search used was online which included advanced search, basic search and also from the audio/video manual on their website.</p><p><strong>Results: </strong>There are 17 primary registries of ICTRP, the first one International Standard Randomised Controlled Trial Number (ISRCTN) of England being initiated in year 2000 and the most recent being Lebanese registry, in September 2019. The trials registered with these registries range from 301 in Cuba to 53972 in European union's EU Clinical Trials Register. The primary registries in WHO registry network are diverse in functionalities and practices. The characteristics of online registers vary in content and features and to achieve coordinated level of data quality, across all the different registries and to keep a balance in standards of the data collected and validation of that data, the registries are adhering to the minimum data set items laid down by ICTRP.</p><p><strong>Conclusion: </strong>The very process of registering the clinical studies helps in promoting the research methods and also raising the standards of research, especially among young researchers. It also helps in reducing the duplicity of research.</p>","PeriodicalId":8720,"journal":{"name":"Ayu","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d2/01/AYU-40-141.PMC7685261.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38678518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Safety profile of Ayurvedic poly‑herbomineral formulation - Bacnil capsule in albino rats. 阿育吠陀多草药制剂Bacnil胶囊在白化病大鼠中的安全性。
Ayu
Pub Date : 2019-07-01 Epub Date: 2020-08-08 DOI: 10.4103/ayu.AYU_64_18
Balaji Panigrahi, Swati Sharma, Bhakti Sitapara, Subrata De, Mukesh Nariya

Introduction: Bacnil capsule is a poly‑herbomineral formulation used to treat gastroenteritis. It contains many potential drugs derived from plant sources and Bhasma (calcined fine powder) preparations.

Aims: The study was designed to ascertain the safety of bacnil capsule orally in Charle's Foster albino rats.

Materials and methods: As per the Organization for Economic Cooperation and Development (OECD) 425 protocol oral acute toxicity study, bacnil capsule was administered orally once only at the dose of 2000 mg/kg in rats. For repeated dose toxicity study, AYUSH 170 and OECD 407, it was administered at three dose levels, Therapeutic doses (TED) (196.2), TED × 5 (981) and TED × 10 (1962) mg/kg/day orally for 28 days in albino rats followed by a 15‑day recovery period only on TED × 10 dose level.

Observation and results: Bacnil at the oral dose of 2000 mg/kg did not produce any toxicity or mortality in albino rats. Repeated dose 28‑day oral toxicity revealed that test formulation did not produce any significant change in serum biochemical, hematological, and histopathological parameters at therapeutic dose level. Mild‑to‑moderate pathological changes were observed in the various serum biochemical and cytoarchitecture of the liver, heart, kidney, and stomach at a dose of 10 TEDs; however, the same was reversed after discontinuation in the recovery test.

Conclusion: Bacnil at 196.2 mg/kg/day is safe at the therapeutic dose level in albino rats.

Bacnil胶囊是一种多草药制剂,用于治疗胃肠炎。它含有许多从植物来源和Bhasma(煅烧细粉)制剂中提取的潜在药物。目的:探讨口服巴肯胶囊对白化大鼠的安全性。材料与方法:根据经济合作与发展组织(OECD) 425方案口服急性毒性研究,大鼠只口服一次巴肯胶囊,剂量为2000 mg/kg。在重复给药毒性研究中,AYUSH 170和OECD 407分别以治疗剂量(TED)(196.2)、TED × 5(981)和TED × 10(1962) 3个剂量水平给药,白化病大鼠口服剂量(TED × 10) mg/kg/天,持续28天,随后仅以TED × 10剂量水平给予15天的恢复期。观察和结果:白化病大鼠口服剂量2000 mg/kg巴肯无毒性,无死亡。重复给药28天口服毒性试验显示,试验制剂在治疗剂量水平下未对血清生化、血液学和组织病理学参数产生任何显著变化。在10 TEDs剂量下,肝脏、心脏、肾脏和胃的各种血清生化和细胞结构发生轻至中度病理改变;然而,在恢复测试中,同样的情况在停药后发生逆转。结论:白化病大鼠治疗剂量196.2 mg/kg/d的巴克尼是安全的。
{"title":"Safety profile of Ayurvedic poly‑herbomineral formulation - Bacnil capsule in albino rats.","authors":"Balaji Panigrahi,&nbsp;Swati Sharma,&nbsp;Bhakti Sitapara,&nbsp;Subrata De,&nbsp;Mukesh Nariya","doi":"10.4103/ayu.AYU_64_18","DOIUrl":"https://doi.org/10.4103/ayu.AYU_64_18","url":null,"abstract":"<p><strong>Introduction: </strong>Bacnil capsule is a poly‑herbomineral formulation used to treat gastroenteritis. It contains many potential drugs derived from plant sources and <i>Bhasma</i> (calcined fine powder) preparations.</p><p><strong>Aims: </strong>The study was designed to ascertain the safety of bacnil capsule orally in Charle's Foster albino rats.</p><p><strong>Materials and methods: </strong>As per the Organization for Economic Cooperation and Development (OECD) 425 protocol oral acute toxicity study, bacnil capsule was administered orally once only at the dose of 2000 mg/kg in rats. For repeated dose toxicity study, AYUSH 170 and OECD 407, it was administered at three dose levels, Therapeutic doses (TED) (196.2), TED × 5 (981) and TED × 10 (1962) mg/kg/day orally for 28 days in albino rats followed by a 15‑day recovery period only on TED × 10 dose level.</p><p><strong>Observation and results: </strong>Bacnil at the oral dose of 2000 mg/kg did not produce any toxicity or mortality in albino rats. Repeated dose 28‑day oral toxicity revealed that test formulation did not produce any significant change in serum biochemical, hematological, and histopathological parameters at therapeutic dose level. Mild‑to‑moderate pathological changes were observed in the various serum biochemical and cytoarchitecture of the liver, heart, kidney, and stomach at a dose of 10 TEDs; however, the same was reversed after discontinuation in the recovery test.</p><p><strong>Conclusion: </strong>Bacnil at 196.2 mg/kg/day is safe at the therapeutic dose level in albino rats.</p>","PeriodicalId":8720,"journal":{"name":"Ayu","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/85/af/AYU-40-185.PMC7685255.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38689825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
An in vitro evaluation of cytotoxicity of curcumin against human periodontal ligament fibroblasts. 姜黄素对人牙周韧带成纤维细胞的体外毒性研究。
Ayu
Pub Date : 2019-07-01 Epub Date: 2020-08-08 DOI: 10.4103/ayu.AYU_294_18
Praveenkumar S Mandroli, A R Prabhakar, Kishore Bhat, Sushma Krishnamurthy, Chetana Bogar

Introduction: Curcumin, a component of turmeric (Curcuma longa L.), is a molecule of multitude of medicinal properties. Although curcumin has found a place in the treatment of gingival and periodontal diseases, there are no reported cytotoxicity studies on the cells of clinical significance (i.e., periodontal ligament [PDL] fibroblasts).

Aims: The objective of this research was to assess the in vitro cytotoxicity of curcumin against human PDL fibroblasts.

Materials and methods: Human PDL fibroblasts from premolar teeth were cultured and used for cytotoxicity tests from healthy children presented for orthodontic extractions. Test concentrations of curcumin (100%, 50%, and 25%) were prepared by diluting 95% curcumin with di‑methyl‑sulfoxide and added to 96‑well microtiter plate (in triplicate) containing the fibroblast culture (approximately 2 × 104 cells/well). Fibroblast cells without treatment (without curcumin) acted as a control group. The viability of cells after 48 h of incubation at 37°C in a humidified atmosphere of 5% CO2 and 95% air was ascertained by the 3‑(4, 5‑dimethyl‑thiazol‑2‑yl)‑2, 5‑diphenyl‑tetrazolium bromide (MTT) assay. The viability of PDL fibroblast cells of experimental wells was expressed relative to that of control, in terms of change in the color intensity. Absorbencies were recorded at 450 nm on a microplate reader with background subtraction at 620 nm. The cell viability at various concentrations of curcumin against the PDL fibroblasts was calculated as mean absorbance (optical density) and percentage values.

Results: Cell viability of PDL fibroblasts to 100%, 50%, and 25% curcumin concentration was 111.75%, 112.50%, and 114.40%, respectively.

Conclusions: No in vitro cytotoxicity was detected for curcumin against human PDL fibroblasts, at any of the concentrations used (100%, 50%, and 25%) by MTT assay at the end of 48 h.

简介:姜黄素是姜黄(Curcuma longa L.)的一种成分,是一种具有多种药用特性的分子。虽然姜黄素在牙龈和牙周疾病的治疗中占有一席之地,但对具有临床意义的细胞(即牙周韧带[PDL]成纤维细胞)的细胞毒性研究尚未报道。目的:研究姜黄素对人PDL成纤维细胞的体外细胞毒性。材料和方法:培养来自前磨牙的人PDL成纤维细胞,并用于正畸拔牙的健康儿童的细胞毒性试验。用二甲基亚砜稀释95%姜黄素,制备测试浓度(100%、50%和25%)的姜黄素,并将其添加到含有成纤维细胞培养物(约2 × 104个细胞/孔)的96孔微滴板(一式三份)。未处理的成纤维细胞(不含姜黄素)作为对照组。采用3 -(4,5 -二甲基噻唑- 2 -基)- 2,5 -二苯基溴化四氮唑(MTT)法测定细胞在37℃5% CO2和95%空气中培养48 h后的活力。以颜色强度的变化来表达实验孔中PDL成纤维细胞相对于对照的活力。在微孔板读卡器上记录450 nm处的吸光度,背景减光度为620 nm。以平均吸光度(光密度)和百分比值计算不同浓度姜黄素对PDL成纤维细胞的细胞活力。结果:100%、50%、25%姜黄素浓度下,PDL成纤维细胞活力分别为111.75%、112.50%、114.40%。结论:48 h后,MTT法未检测到姜黄素在任何浓度(100%、50%和25%)下对人PDL成纤维细胞的体外细胞毒性。
{"title":"An <i>in vitro</i> evaluation of cytotoxicity of curcumin against human periodontal ligament fibroblasts.","authors":"Praveenkumar S Mandroli,&nbsp;A R Prabhakar,&nbsp;Kishore Bhat,&nbsp;Sushma Krishnamurthy,&nbsp;Chetana Bogar","doi":"10.4103/ayu.AYU_294_18","DOIUrl":"https://doi.org/10.4103/ayu.AYU_294_18","url":null,"abstract":"<p><strong>Introduction: </strong>Curcumin, a component of turmeric (<i>Curcuma</i> <i>longa</i> L.), is a molecule of multitude of medicinal properties. Although curcumin has found a place in the treatment of gingival and periodontal diseases, there are no reported cytotoxicity studies on the cells of clinical significance (i.e., periodontal ligament [PDL] fibroblasts).</p><p><strong>Aims: </strong>The objective of this research was to assess the <i>in vitro</i> cytotoxicity of curcumin against human PDL fibroblasts.</p><p><strong>Materials and methods: </strong>Human PDL fibroblasts from premolar teeth were cultured and used for cytotoxicity tests from healthy children presented for orthodontic extractions. Test concentrations of curcumin (100%, 50%, and 25%) were prepared by diluting 95% curcumin with di‑methyl‑sulfoxide and added to 96‑well microtiter plate (in triplicate) containing the fibroblast culture (approximately 2 × 104 cells/well). Fibroblast cells without treatment (without curcumin) acted as a control group. The viability of cells after 48 h of incubation at 37°C in a humidified atmosphere of 5% CO<sub>2</sub> and 95% air was ascertained by the 3‑(4, 5‑dimethyl‑thiazol‑2‑yl)‑2, 5‑diphenyl‑tetrazolium bromide (MTT) assay. The viability of PDL fibroblast cells of experimental wells was expressed relative to that of control, in terms of change in the color intensity. Absorbencies were recorded at 450 nm on a microplate reader with background subtraction at 620 nm. The cell viability at various concentrations of curcumin against the PDL fibroblasts was calculated as mean absorbance (optical density) and percentage values.</p><p><strong>Results: </strong>Cell viability of PDL fibroblasts to 100%, 50%, and 25% curcumin concentration was 111.75%, 112.50%, and 114.40%, respectively.</p><p><strong>Conclusions: </strong>No <i>in vitro</i> cytotoxicity was detected for curcumin against human PDL fibroblasts, at any of the concentrations used (100%, 50%, and 25%) by MTT assay at the end of 48 h.</p>","PeriodicalId":8720,"journal":{"name":"Ayu","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e4/d0/AYU-40-192.PMC7685259.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38680186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Efficacy of Sattvavajaya Chikitsa in the form of relaxation techniques and Guda Pippalimula Churna in the management of Anidra (insomnia) - An open labelled, randomized comparative clinical trial. Sattvavajaya Chikitsa以放松技术的形式和Guda Pippalimula Churna在Anidra(失眠)管理中的疗效-一项开放标记,随机对照临床试验。
Ayu
Pub Date : 2019-04-01 Epub Date: 2020-03-20 DOI: 10.4103/ayu.AYU_91_17
Priyanka Rawal, Mahesh Vyas, A S Baghel, Shubhangi Kamble

Background: Condition of insomnia may not be a life-threatening illness, but it has tendency to damage the person's daily life. In the current era of modernization, most of the person are is suffering from stress either it is personal or professional. Stress may cause sleeping problems or make existing problems worse. Sattvavajaya Chikitsa is a specialized type of treatment influencing the psychological aspect of body. It can be applied in the form of Yogic practices and other mind control techniques. With this research interest, the present study has been undertaken to assess the efficacy of the Sattvavajaya Chikitsa in the form of relaxation techniques (RT) and Guda Pippalimula Churna in Anidra (insomnia).

Objectives: The objective of the study was to evaluate the efficacy of Sattvavajaya Chikitsa in the form of RT and Guda Pippalimula Churna in Anidra.

Materials and methods: The study was an open-labeled randomized clinical trial in which sixty patients having symptoms of Anidra belonging to the age group of 20-60 years were enrolled and received Sattvavajaya Chikitsa (RT) and Guda Pippalimula Churna orally in 2gm dosage with jaggery for 28 days. The assessment of symptoms was done on the basis of relief in the scores given to signs and symptoms according to their severity.

Results: Both the groups showed significant results in chief as well as associated symptoms of disease. Regarding overall effect of therapy in both the groups, marked improvement is high followed by moderate improvement. No adverse reactions were documented.

Conclusion: Sattvavajaya Chikitsa and Guda Pippalimula Churna are effective on Anidra, but Sattvavajaya Chikitsa was found more effective in reducing Manasa symptoms such as Chinta (tension), Bhaya (fear) and Krodha (anger).

背景:失眠症可能不是一种危及生命的疾病,但它有损害人的日常生活的倾向。在当今现代化的时代,大多数人都承受着压力,无论是个人的还是职业的。压力可能会导致睡眠问题或使现有问题恶化。Sattvavajaya Chikitsa是一种影响身体心理方面的专门治疗方法。它可以以瑜伽练习和其他精神控制技术的形式应用。基于这一研究兴趣,本研究旨在评估Sattvavajaya Chikitsa以放松技术(RT)和Guda Pippalimula Churna的形式对Anidra(失眠)的疗效。目的:本研究的目的是评估以RT和guuda Pippalimula Churna形式的sattavavajaya Chikitsa在Anidra中的疗效。材料和方法:本研究是一项开放标记随机临床试验,纳入60例年龄在20-60岁的有Anidra症状的患者,接受Sattvavajaya Chikitsa (RT)和Guda Pippalimula Churna口服2gm剂量,加糖治疗28天。症状的评估是根据症状和体征的严重程度评分的缓解程度来进行的。结果:两组均表现出显著的主要结果以及相关的疾病症状。两组治疗的总体效果均为显著改善高,随后为中度改善。无不良反应记录。结论:禅定法和古达法对无尼陀有效,但禅定法对缓解紧张、恐惧和愤怒等症状更有效。
{"title":"Efficacy of <i>Sattvavajaya Chikitsa</i> in the form of relaxation techniques and <i>Guda Pippalimula Churna</i> in the management of <i>Anidra</i> (insomnia) - An open labelled, randomized comparative clinical trial.","authors":"Priyanka Rawal,&nbsp;Mahesh Vyas,&nbsp;A S Baghel,&nbsp;Shubhangi Kamble","doi":"10.4103/ayu.AYU_91_17","DOIUrl":"https://doi.org/10.4103/ayu.AYU_91_17","url":null,"abstract":"<p><strong>Background: </strong>Condition of insomnia may not be a life-threatening illness, but it has tendency to damage the person's daily life. In the current era of modernization, most of the person are is suffering from stress either it is personal or professional. Stress may cause sleeping problems or make existing problems worse. <i>Sattvavajaya</i> <i>Chikitsa</i> is a specialized type of treatment influencing the psychological aspect of body. It can be applied in the form of <i>Yogic</i> practices and other mind control techniques. With this research interest, the present study has been undertaken to assess the efficacy of the <i>Sattvavajaya</i> <i>Chikitsa</i> in the form of relaxation techniques (RT) and <i>Guda</i> <i>Pippalimula</i> <i>Churna</i> in <i>Anidra</i> (insomnia).</p><p><strong>Objectives: </strong>The objective of the study was to evaluate the efficacy of <i>Sattvavajaya</i> <i>Chikitsa</i> in the form of RT and <i>Guda</i> <i>Pippalimula</i> <i>Churna</i> in <i>Anidra</i>.</p><p><strong>Materials and methods: </strong>The study was an open-labeled randomized clinical trial in which sixty patients having symptoms of <i>Anidra</i> belonging to the age group of 20-60 years were enrolled and received <i>Sattvavajaya</i> <i>Chikitsa</i> (RT) and <i>Guda</i> <i>Pippalimula</i> <i>Churna</i> orally in 2gm dosage with jaggery for 28 days. The assessment of symptoms was done on the basis of relief in the scores given to signs and symptoms according to their severity.</p><p><strong>Results: </strong>Both the groups showed significant results in chief as well as associated symptoms of disease. Regarding overall effect of therapy in both the groups, marked improvement is high followed by moderate improvement. No adverse reactions were documented.</p><p><strong>Conclusion: </strong><i>Sattvavajaya</i> <i>Chikitsa</i> and <i>Guda</i> <i>Pippalimula</i> <i>Churna</i> are effective on <i>Anidra</i>, but <i>Sattvavajaya</i> <i>Chikitsa</i> was found more effective in reducing <i>Manasa</i> symptoms such as <i>Chinta</i> (tension), <i>Bhaya</i> (fear) and <i>Krodha</i> (anger).</p>","PeriodicalId":8720,"journal":{"name":"Ayu","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/7e/2a/AYU-40-89.PMC7210826.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37928538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Turmeric based oral rinse "HTOR-091516" ameliorates experimental oral mucositis. 基于姜黄的口腔冲洗液“HTOR-091516”改善实验性口腔黏膜炎。
Ayu
Pub Date : 2019-04-01 Epub Date: 2020-03-20 DOI: 10.4103/ayu.AYU_282_18
Suryakanth Dattatreya Anturlikar, Mohammed Mukhram Azeemuddin, Sandeep Varma, Onkaramurthy Mallappa, Dilip Niranjan, Ashok Basti Krishnaiah, Shruthi Manjunath Hegde, Mohamed Rafiq, Rangesh Paramesh

Background: Prevalence and incidence of oral mucositis (OM) are rigorously increasing and there is no effective treatment. The herbal formulation "HTOR-091516" containing Curcuma longa, Triphala and honey were evaluated for the treatment of OM.

Aim: The aim of this study was to evaluate the safety and efficacy of HTOR-091516, employing cellular model, human gingival fibroblasts-1 (HGF-1), and 5-fluorouracil (5-FU)-induced mucositis model in rats.

Materials and methods: The cell viability was assessed using 3-(4, 5-dimethylthiazolyl-2)-2, 5-diphenyltetrazolium bromide (MTT) assay and the inhibitory effect of HTOR-091516 on tumor necrosis factor-alpha (TNF-α) was evaluated using TNF-α bioassay in lipopolysaccharides-induced HGF-1. 5-FU and glacial acetic acid were used to induce OM in rats. Animals were divided into two groups, group 1 served as mucositis control and group 2 was treated with HTOR-091516 at the dose of 200 μl and TNF-α was estimated in plasma samples.

Results: The in vitro safety of HTOR-091516 was evaluated in reconstructed human oral epidermis and was found to be nontoxic and exhibited concentration-dependent TNF-α inhibition in HGF-1. The treatment with HTOR-091516 reduced mucositis scores and mortality rate and also decreased the plasma TNF-α level.

Conclusion: The present data indicate that HTOR-091516 is effective in the treatment of OM.

背景:口腔黏膜炎(OM)的患病率和发病率正在急剧上升,目前尚无有效的治疗方法。对含姜黄、Triphala、蜂蜜的中药制剂HTOR-091516治疗OM的疗效进行了评价。目的:采用细胞模型、人牙龈成纤维细胞-1 (HGF-1)和5-氟尿嘧啶(5-FU)诱导大鼠粘膜炎模型,评价HTOR-091516的安全性和有效性。材料与方法:采用3-(4,5 -二甲基噻唑-2)- 2,5 -二苯基溴化四唑(MTT)法测定细胞活力,采用TNF-α生物测定法测定HTOR-091516对脂多糖诱导的HGF-1的抑制作用。用5-FU和冰醋酸诱导大鼠OM。将动物分为两组,1组作为黏膜炎对照组,2组用200 μl剂量的HTOR-091516治疗,测定血浆样品中TNF-α的含量。结果:HTOR-091516体外安全性在重建的人口腔表皮中进行了评估,发现其无毒且对HGF-1具有浓度依赖性的TNF-α抑制作用。HTOR-091516治疗可降低黏膜炎评分和死亡率,降低血浆TNF-α水平。结论:HTOR-091516治疗OM有较好的疗效。
{"title":"Turmeric based oral rinse \"HTOR-091516\" ameliorates experimental oral mucositis.","authors":"Suryakanth Dattatreya Anturlikar,&nbsp;Mohammed Mukhram Azeemuddin,&nbsp;Sandeep Varma,&nbsp;Onkaramurthy Mallappa,&nbsp;Dilip Niranjan,&nbsp;Ashok Basti Krishnaiah,&nbsp;Shruthi Manjunath Hegde,&nbsp;Mohamed Rafiq,&nbsp;Rangesh Paramesh","doi":"10.4103/ayu.AYU_282_18","DOIUrl":"https://doi.org/10.4103/ayu.AYU_282_18","url":null,"abstract":"<p><strong>Background: </strong>Prevalence and incidence of oral mucositis (OM) are rigorously increasing and there is no effective treatment. The herbal formulation \"HTOR-091516\" containing <i>Curcuma longa</i>, <i>Triphala</i> and honey were evaluated for the treatment of OM.</p><p><strong>Aim: </strong>The aim of this study was to evaluate the safety and efficacy of HTOR-091516, employing cellular model, human gingival fibroblasts-1 (HGF-1), and 5-fluorouracil (5-FU)-induced mucositis model in rats.</p><p><strong>Materials and methods: </strong>The cell viability was assessed using 3-(4, 5-dimethylthiazolyl-2)-2, 5-diphenyltetrazolium bromide (MTT) assay and the inhibitory effect of HTOR-091516 on tumor necrosis factor-alpha (TNF-α) was evaluated using TNF-α bioassay in lipopolysaccharides-induced HGF-1. 5-FU and glacial acetic acid were used to induce OM in rats. Animals were divided into two groups, group 1 served as mucositis control and group 2 was treated with HTOR-091516 at the dose of 200 μl and TNF-α was estimated in plasma samples.</p><p><strong>Results: </strong>The <i>in vitro</i> safety of HTOR-091516 was evaluated in reconstructed human oral epidermis and was found to be nontoxic and exhibited concentration-dependent TNF-α inhibition in HGF-1. The treatment with HTOR-091516 reduced mucositis scores and mortality rate and also decreased the plasma TNF-α level.</p><p><strong>Conclusion: </strong>The present data indicate that HTOR-091516 is effective in the treatment of OM.</p>","PeriodicalId":8720,"journal":{"name":"Ayu","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ca/ce/AYU-40-127.PMC7210821.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37928439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Illusion of the "p-value" theory in Ayurveda research: A need for perceptible alternative. 阿育吠陀研究中“p值”理论的幻觉:需要可感知的替代。
Ayu
Pub Date : 2019-04-01 Epub Date: 2020-03-20 DOI: 10.4103/ayu.AYU_52_19
Arunabh Tripathi, Saket Ram Trigulla
Reporting and interpretation of results of classical statistical tests is widespread among applied researchers, most of whom erroneously believe that such tests are prescribed by a single coherent theory of statistical inference. This is not the case, classical statistical testing is a hybrid of the two different approaches formulated by Fisher on the one hand and Jerzy Neyman and Egon Pearson on the other.[1,2]
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引用次数: 1
Effect of Agnikarma (therapeutic heat burns) and Raktamokshana (therapeutic bloodletting) in the management of Kati Sandhigata Vata (lumbar spondylosis). Agnikarma(热烧伤治疗)和Raktamokshana(放血治疗)在腰椎病治疗中的作用。
Ayu
Pub Date : 2019-04-01 Epub Date: 2020-03-20 DOI: 10.4103/ayu.AYU_142_16
Foram Joshi, Vyasadeva Mahanta, Tukaram S Dudhamal, Sanjay Kumar Gupta

Background: Agnikarma (therapeutic heat burns) and Raktamokshana (therapeutic bloodletting) are the treatment modalities mentioned in Ayurveda texts to combat the clinical condition of Sandhigata Vata (osteoarthritis) which occurs due to provoked Vata Dosha and/or Vyana Vayu overlapped with Kapha. Lumbar spondylosis is a degenerative disorder presenting with lower back pain, stiffness, numbness, difficulty in movement etc., with evidence of osteophytes and reduced disc height in plain film radiograph.

Aims and objectives: The aim of the study was to evaluate the role of Agnikarma and Raktamokshana in the management of Kati Sandhigata Vata (lumbar spondylosis).

Materials and methods: After obtaining CTRI registration, total 32 cases of lumbar spondylosis were registered and allocated into two groups by simple random sampling method. 16 patients were treated with Agnikarma with Panchadhatu Shalaka (group A) and 16 patients were treated with Raktamokshana by modified Shringa Yantra (group B).

Results: The result was assessed using the Wilcoxon signed-rank test and paired t-test. Significant results were observed in relieving lower back pain, stiffness, numbness and painful movements in both the groups.

Conclusion: Agnikarma was found more effective in relieving pain and numbness in lower back and Raktamokshana was found better in relieving pain and stiffness of lower back.

背景:Agnikarma(治疗性热烧伤)和Raktamokshana(治疗性放血)是阿育吠陀文献中提到的治疗方式,用于对抗因Vata Dosha和/或Vyana Vayu与Kapha重叠而引起的Sandhigata Vata(骨关节炎)的临床状况。腰椎病是一种退行性疾病,表现为下背部疼痛、僵硬、麻木、活动困难等,平片表现为骨赘和椎间盘高度降低。目的和目的:本研究的目的是评估Agnikarma和Raktamokshana在腰椎病治疗中的作用。材料与方法:获得CTRI登记后,将32例腰椎病患者登记,采用简单随机抽样法分为两组。16例患者采用Panchadhatu Shalaka治疗Agnikarma (A组),16例患者采用改良Shringa Yantra治疗Raktamokshana (B组)。结果:采用Wilcoxon符号秩检验和配对t检验对结果进行评估。两组患者在缓解腰痛、僵硬、麻木和疼痛运动方面均有显著效果。结论:阿格尼伽玛对缓解下背部疼痛和麻木更有效,而罗曲莫散对缓解下背部疼痛和僵硬更有效。
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引用次数: 4
期刊
Ayu
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