J. Zvekic-Svorcan, I. Minaković, K. Boskovic, D. Simic-Panic, J. Mikov, Natasa Igic
Introduction. The purpose of treating osteoarthritis is to relieve pain, improve the function of the osteoarthritic joint, and arrest further development of osteoarthritis through non-pharmacological and pharmacological treatment modalities. Pharmacological osteoarthritis therapy. In the treatment of osteoarthritis, guidelines and recommendations are often consulted, but they do not dictate the treatment mode, which is tailored to the individual needs of the patient. These guidelines promote desired and positive treatment outcomes, but cannot predict a specific outcome. They are also valuable when analyzing the use of topical and oral non-steroidal anti-inflammatory drugs, keeping dosage as low as possible for the shortest time. For example, monitoring hepatotoxicity is advised when administering paracetamol, while caution is needed when prescribing drugs with a central effect due to the possible development of addiction and appearance of toxic effects. A significant body of research on the use of chondroprotectors exists, but there is a large discrepancy across studies. Nonetheless, their findings indicate benefits of intra-articular administration of glucocorticoids. However, their more frequent administration can lead to accelerated cartilage loss, while guidelines differ concerning intra-articular administration of hyaluronic acid, the administration of plasma enriched with platelets, and the administration of stem cells due to the heterogeneity of the preparations and the lack of standardization in their administration. Conclusion. Non-surgical therapy is a growing field of research, especially from a pharmacological point of view, intending to find the best treatment to slow down or completely stop further development of osteoarthritis.
{"title":"Pharmacological osteoarthritis therapy and modern therapeutic principles","authors":"J. Zvekic-Svorcan, I. Minaković, K. Boskovic, D. Simic-Panic, J. Mikov, Natasa Igic","doi":"10.2298/mpns22s2047z","DOIUrl":"https://doi.org/10.2298/mpns22s2047z","url":null,"abstract":"Introduction. The purpose of treating osteoarthritis is to relieve pain, improve the function of the osteoarthritic joint, and arrest further development of osteoarthritis through non-pharmacological and pharmacological treatment modalities. Pharmacological osteoarthritis therapy. In the treatment of osteoarthritis, guidelines and recommendations are often consulted, but they do not dictate the treatment mode, which is tailored to the individual needs of the patient. These guidelines promote desired and positive treatment outcomes, but cannot predict a specific outcome. They are also valuable when analyzing the use of topical and oral non-steroidal anti-inflammatory drugs, keeping dosage as low as possible for the shortest time. For example, monitoring hepatotoxicity is advised when administering paracetamol, while caution is needed when prescribing drugs with a central effect due to the possible development of addiction and appearance of toxic effects. A significant body of research on the use of chondroprotectors exists, but there is a large discrepancy across studies. Nonetheless, their findings indicate benefits of intra-articular administration of glucocorticoids. However, their more frequent administration can lead to accelerated cartilage loss, while guidelines differ concerning intra-articular administration of hyaluronic acid, the administration of plasma enriched with platelets, and the administration of stem cells due to the heterogeneity of the preparations and the lack of standardization in their administration. Conclusion. Non-surgical therapy is a growing field of research, especially from a pharmacological point of view, intending to find the best treatment to slow down or completely stop further development of osteoarthritis.","PeriodicalId":87940,"journal":{"name":"Calcutta medical review","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78778623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction. Peripheral joint osteoarthritis is the leading cause of musculoskeletal pain and functional limitation. Osteoarthritis has a high prevalence and incidence and, therefore great socioeconomic importance. Clinical presentation. Pain in osteoarthritis results from a complex interaction of sensory, affective, and cognitive processes that include numerous abnormal cellular mechanisms at the affected joints and different levels of the nervous system involved in the pathophysiological mechanisms of chronic pain (spinal and supraspinal). In chronic pain states, central nervous system factors are particularly prominent. Although there are several ways to determine pain sensitivity, data suggest that assessing pressure pain threshold (i.e., tenderness to palpation) is the most reliable and reproducible method for identifying individuals with a centralized pain state. Conclusion. Significant advances in our understanding of pain pathophysiology and pain biomarkers are finally making the vision of ?personalized analgesia?. Clinicians can identify the sub-sets of individuals with what were once considered purely ?peripheral? pain syndromes and treat these patients with approaches directed more centrally than peripherally.
{"title":"Pain in focus in patients with osteoarthritis","authors":"S. Tomasevic-Todorovic, T. Spasojevic","doi":"10.2298/mpns22s2043t","DOIUrl":"https://doi.org/10.2298/mpns22s2043t","url":null,"abstract":"Introduction. Peripheral joint osteoarthritis is the leading cause of musculoskeletal pain and functional limitation. Osteoarthritis has a high prevalence and incidence and, therefore great socioeconomic importance. Clinical presentation. Pain in osteoarthritis results from a complex interaction of sensory, affective, and cognitive processes that include numerous abnormal cellular mechanisms at the affected joints and different levels of the nervous system involved in the pathophysiological mechanisms of chronic pain (spinal and supraspinal). In chronic pain states, central nervous system factors are particularly prominent. Although there are several ways to determine pain sensitivity, data suggest that assessing pressure pain threshold (i.e., tenderness to palpation) is the most reliable and reproducible method for identifying individuals with a centralized pain state. Conclusion. Significant advances in our understanding of pain pathophysiology and pain biomarkers are finally making the vision of ?personalized analgesia?. Clinicians can identify the sub-sets of individuals with what were once considered purely ?peripheral? pain syndromes and treat these patients with approaches directed more centrally than peripherally.","PeriodicalId":87940,"journal":{"name":"Calcutta medical review","volume":"96 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88516447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
B. Golubović, S. Slavković, Z. Gajic, Aleksandra Becagul
Introduction. Disorders of cognitive functioning in patients with psychosis can manifest in different domains. The disorders vary depending on the severity, from mild to severe, and on the severity of symptoms within the underlying disease. The aim of this study was to examine the possibility of using the Audio Recorded Cognitive Screen in patients with schizophrenia. Material and Methods. The study included a total of 61 subjects divided into two groups: 31 subjects with schizophrenia and 30 healthy controls. All subjects completed the Audio Recorded Cognitive Screen to assess the cognitive status in five domains of cognitive functioning. Results. The Audio Recorded Cognitive Screen showed a good reliability index (? = 0.85). Multivariate analysis of variance confirmed the differences between the two groups in all examined cognitive domains (F (6.53) = 26.719, p < .001). The partial eta squared results were as follows: object naming 0.159; immediate recall 0.531; delayed recall 0.585; visuospatial functions 0.334; attention 0.644; and verbal fluency 0.590. These results indicated significant differences between the two groups. Conclusion. The Audio Recorded Cognitive Screen is a feasible tool for the detection of neurocognitive impairment in individuals with schizophrenia. However, it is necessary to conduct further research in larger samples and use additional assessment instruments in this population.
介绍。精神病患者的认知功能障碍可以表现在不同的领域。这些疾病根据严重程度，从轻微到严重，以及潜在疾病的症状严重程度而有所不同。本研究的目的是探讨在精神分裂症患者中使用录音认知屏幕的可能性。材料和方法。该研究共包括61名受试者，分为两组:31名精神分裂症患者和30名健康对照者。所有被试均完成了认知录音测试，以评估他们在五个认知功能领域的认知状态。结果。录音认知屏幕显示出良好的可靠性指数(?= 0.85)。多因素方差分析证实了两组在所有检查的认知领域的差异(F (6.53) = 26.719, p < 0.001)。偏eta平方结果如下:对象命名0.159;立即召回0.531;延迟召回0.585;视觉空间函数0.334;注意0.644;语言流利度0.590。这些结果表明两组之间存在显著差异。结论。录音认知屏幕是一种可行的工具，用于检测精神分裂症患者的神经认知障碍。然而，有必要在更大的样本中进行进一步的研究，并在这一人群中使用额外的评估工具。
{"title":"The audio recorded cognitive screen for brief screening of cognitive impairment in patients with psychosis: A pilot study","authors":"B. Golubović, S. Slavković, Z. Gajic, Aleksandra Becagul","doi":"10.2298/mpns2202026g","DOIUrl":"https://doi.org/10.2298/mpns2202026g","url":null,"abstract":"Introduction. Disorders of cognitive functioning in patients with psychosis can manifest in different domains. The disorders vary depending on the severity, from mild to severe, and on the severity of symptoms within the underlying disease. The aim of this study was to examine the possibility of using the Audio Recorded Cognitive Screen in patients with schizophrenia. Material and Methods. The study included a total of 61 subjects divided into two groups: 31 subjects with schizophrenia and 30 healthy controls. All subjects completed the Audio Recorded Cognitive Screen to assess the cognitive status in five domains of cognitive functioning. Results. The Audio Recorded Cognitive Screen showed a good reliability index (? = 0.85). Multivariate analysis of variance confirmed the differences between the two groups in all examined cognitive domains (F (6.53) = 26.719, p < .001). The partial eta squared results were as follows: object naming 0.159; immediate recall 0.531; delayed recall 0.585; visuospatial functions 0.334; attention 0.644; and verbal fluency 0.590. These results indicated significant differences between the two groups. Conclusion. The Audio Recorded Cognitive Screen is a feasible tool for the detection of neurocognitive impairment in individuals with schizophrenia. However, it is necessary to conduct further research in larger samples and use additional assessment instruments in this population.","PeriodicalId":87940,"journal":{"name":"Calcutta medical review","volume":"546 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91252979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction. Acute lymphoblastic leukemia is a malignant disease characterized by the proliferation of precursor B-cells, Tcells or less often, precursors of NK-cells. B-cell acute lymphoblastic leukemia is more common in patients >60 years of age compared to patients <60 years of age (89% vs. 66%), and cytogenetic abnormalities such as t(9;22) (Ph+) are more common in older than younger patients (36% against 19%). Elderly patients often have a poor status and comorbidities, so poor disease outcome is more common. Clinical and biological features. B cell acute lymphoblastic leukemia is more common in patients >60 years of age compared to patients <60 years of age (89% vs 66%) and cytogenetic abnormalities such as t(9;22) are more common in older vs. younger (36% vs. 19%). Therapy. The elderly and patients with comorbidities require less intensive therapy, based on corticosteroids, vincristine and asparaginase, while avoiding anthracyclines and alkylating agents, due to the high mortality associated with treatment. For ?unfit? patients with Ph-positive acute lymphoblastic leukemia, tyrosine kinase inhibitors with reduced-intensity chemotherapy or corticosteroids alone are recommended. For t(9;22) negative patients, low-dose corticosteroid chemotherapy with or without immunotherapy is recommended. For patients with T-cell acute lymphoblastic leukemia, chemotherapy with venetoclax may be an option. Conclusion. The introduction of targeted therapy has changed treatment options in acute lymphoblastic leukemia. For elderly patients, targeted therapy is a necessary modality since standard chemotherapy leads to a poor outcome due to its toxicity and ineffectiveness.
{"title":"Treatment of patients with acute lymphoblastic leukemia who are not suitable for high-dose chemotherapy and hematopoietic stem cell transplantation","authors":"N. Govedarović","doi":"10.2298/mpns22s1019g","DOIUrl":"https://doi.org/10.2298/mpns22s1019g","url":null,"abstract":"Introduction. Acute lymphoblastic leukemia is a malignant disease characterized by the proliferation of precursor B-cells, Tcells or less often, precursors of NK-cells. B-cell acute lymphoblastic leukemia is more common in patients >60 years of age compared to patients <60 years of age (89% vs. 66%), and cytogenetic abnormalities such as t(9;22) (Ph+) are more common in older than younger patients (36% against 19%). Elderly patients often have a poor status and comorbidities, so poor disease outcome is more common. Clinical and biological features. B cell acute lymphoblastic leukemia is more common in patients >60 years of age compared to patients <60 years of age (89% vs 66%) and cytogenetic abnormalities such as t(9;22) are more common in older vs. younger (36% vs. 19%). Therapy. The elderly and patients with comorbidities require less intensive therapy, based on corticosteroids, vincristine and asparaginase, while avoiding anthracyclines and alkylating agents, due to the high mortality associated with treatment. For ?unfit? patients with Ph-positive acute lymphoblastic leukemia, tyrosine kinase inhibitors with reduced-intensity chemotherapy or corticosteroids alone are recommended. For t(9;22) negative patients, low-dose corticosteroid chemotherapy with or without immunotherapy is recommended. For patients with T-cell acute lymphoblastic leukemia, chemotherapy with venetoclax may be an option. Conclusion. The introduction of targeted therapy has changed treatment options in acute lymphoblastic leukemia. For elderly patients, targeted therapy is a necessary modality since standard chemotherapy leads to a poor outcome due to its toxicity and ineffectiveness.","PeriodicalId":87940,"journal":{"name":"Calcutta medical review","volume":"294 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90384252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sonja Sedlarevic, Bozidar Dejanovic, Z. Savic, Bojan Vuković, Vanja Calic, M. Lekin
Introduction. Purple urine bag syndrome is a condition where the urinary catheter bag turns purple as a result of the interaction between bacteria, urine and components of the urine bag. It appears in a certain group of patients with the following risk factors: urinary tract infection, older age, long-term indwelling urinary catheter, constipation, chronic kidney disease. Case Report. Two patients with purple urine bag syndrome are presented. The first patient, a 66-year-old man, was hospitalized due to decompensation of alcoholic liver cirrhosis. A urinary catheter was placed on admission, and on the fourteenth day of hospitalization, a purple discoloration of the urine in the urinary bag was noticed. Multidrug-resistant Proteus mirabilis and Enterococcus faecalis were isolated by microbiological analysis of urine. The second patient was a 92-year-old man, hospitalized for acute gastrointestinal bleeding in the form of hematochezia, with an indwelling urinary catheter and a history of a prostate cancer surgery. On the third hospital day, a purple content in the urinary catheter bag was detected and Klebsiella pneumoniae and Morganella morganii were confirmed by bacteriological analysis. Both patients were without clinical and laboratory signs of acute infection. In both cases, the urinary catheter was replaced and ceftriaxone was administered empirically. Conclusion. Current guidelines for purple urine bag syndrome recommend catheter replacement and empiric antibiotic therapy. In clinical practice, it is necessary to emphasize that urine sampling for bacteriological analysis is performed only after replacing the catheter, in order to establish the exact etiology of the syndrome and radical use of antibiotics.
{"title":"Purple urine bag syndrome - a sign of urinary tract infection, or just of urinary catheter bacterial colonization: A case report","authors":"Sonja Sedlarevic, Bozidar Dejanovic, Z. Savic, Bojan Vuković, Vanja Calic, M. Lekin","doi":"10.2298/mpns2210301s","DOIUrl":"https://doi.org/10.2298/mpns2210301s","url":null,"abstract":"Introduction. Purple urine bag syndrome is a condition where the urinary catheter bag turns purple as a result of the interaction between bacteria, urine and components of the urine bag. It appears in a certain group of patients with the following risk factors: urinary tract infection, older age, long-term indwelling urinary catheter, constipation, chronic kidney disease. Case Report. Two patients with purple urine bag syndrome are presented. The first patient, a 66-year-old man, was hospitalized due to decompensation of alcoholic liver cirrhosis. A urinary catheter was placed on admission, and on the fourteenth day of hospitalization, a purple discoloration of the urine in the urinary bag was noticed. Multidrug-resistant Proteus mirabilis and Enterococcus faecalis were isolated by microbiological analysis of urine. The second patient was a 92-year-old man, hospitalized for acute gastrointestinal bleeding in the form of hematochezia, with an indwelling urinary catheter and a history of a prostate cancer surgery. On the third hospital day, a purple content in the urinary catheter bag was detected and Klebsiella pneumoniae and Morganella morganii were confirmed by bacteriological analysis. Both patients were without clinical and laboratory signs of acute infection. In both cases, the urinary catheter was replaced and ceftriaxone was administered empirically. Conclusion. Current guidelines for purple urine bag syndrome recommend catheter replacement and empiric antibiotic therapy. In clinical practice, it is necessary to emphasize that urine sampling for bacteriological analysis is performed only after replacing the catheter, in order to establish the exact etiology of the syndrome and radical use of antibiotics.","PeriodicalId":87940,"journal":{"name":"Calcutta medical review","volume":"87 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85747933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Vidović, D. Šefer, J. Rajić, Tara Gunjak, V. Milošević, S. Jovanović
Intensive chemotherapy/radiotherapy in cancer, especially with hematologic malignancies, causes cellular injury and suppression of inflammatory responses, which increase the risks of neutropenia and febrile episodes. Absolute neutrophil count < 1 ? 109/L is considered neutropenia, with absolute neutrophil count < 0.5 ? 109/L or < 1 ? 109/L that is expected to decrease to < 0.5 ? 109/L in the next 48 hours considered severe neutropenia, while absolute neutrophil count < 0.1 ? 109 is referred as profound neutropenia. Febrile episodes are usually defined as oral temperature > 38.3?C or two consecutive readings > 38.0?C lasting more than 1 hour. Although there is the possibility of non-infection-caused febrile neutropenia, most episodes are caused by infections. Febrile neutropenia is a clinical emergency that requires prompt management. Despite advances in therapy in recent years, febrile neutropenia remains a common complication in chemotherapy causing serious clinical results, including death. The administration of empirical antibacterial therapy has been successful in the management of febrile neutropenia since its launching 50 years ago. The wide application of broad-spectrum antibiotics has effectively decreased the mortality of febrile neutropenia patients. Neutropenic patients who remain febrile despite 4-7 days of broad-spectrum antibacterial therapy are at a high risk of invasive fungal infection. Empirical antifungal therapy with Amphotericin B or Caspofungin in persistently febrile neutropenic patients and other high-risk patients has shown to reduce the risk of invasive fungal infection by 50 - 80% and the risk of fungal infection-related mortality by 23- 45%. Lipid formulations which improve the therapeutic ratio of the traditional formulation are available
{"title":"Febrile neutropenia in patients with hematological malignancies - definition, diagnosis and management","authors":"A. Vidović, D. Šefer, J. Rajić, Tara Gunjak, V. Milošević, S. Jovanović","doi":"10.2298/mpns22s1161v","DOIUrl":"https://doi.org/10.2298/mpns22s1161v","url":null,"abstract":"Intensive chemotherapy/radiotherapy in cancer, especially with hematologic malignancies, causes cellular injury and suppression of inflammatory responses, which increase the risks of neutropenia and febrile episodes. Absolute neutrophil count < 1 ? 109/L is considered neutropenia, with absolute neutrophil count < 0.5 ? 109/L or < 1 ? 109/L that is expected to decrease to < 0.5 ? 109/L in the next 48 hours considered severe neutropenia, while absolute neutrophil count < 0.1 ? 109 is referred as profound neutropenia. Febrile episodes are usually defined as oral temperature > 38.3?C or two consecutive readings > 38.0?C lasting more than 1 hour. Although there is the possibility of non-infection-caused febrile neutropenia, most episodes are caused by infections. Febrile neutropenia is a clinical emergency that requires prompt management. Despite advances in therapy in recent years, febrile neutropenia remains a common complication in chemotherapy causing serious clinical results, including death. The administration of empirical antibacterial therapy has been successful in the management of febrile neutropenia since its launching 50 years ago. The wide application of broad-spectrum antibiotics has effectively decreased the mortality of febrile neutropenia patients. Neutropenic patients who remain febrile despite 4-7 days of broad-spectrum antibacterial therapy are at a high risk of invasive fungal infection. Empirical antifungal therapy with Amphotericin B or Caspofungin in persistently febrile neutropenic patients and other high-risk patients has shown to reduce the risk of invasive fungal infection by 50 - 80% and the risk of fungal infection-related mortality by 23- 45%. Lipid formulations which improve the therapeutic ratio of the traditional formulation are available","PeriodicalId":87940,"journal":{"name":"Calcutta medical review","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86935368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dajana Dedic, Aleksandra Kovac, S. Popović-Petrović, Ivana Zelic-Kozomora
Introduction. The psychological status of patients with breast cancer is often compromised as a result of chronic exposure to negative emotions and psychological distress after the diagnosis of a malignant disease and conditions such as depression and anxiety may have a direct impact on the functional wellbeing of breast cancer patients. The aim of this study was to examine whether depression affects the functional well-being of breast cancer patients. Material and Methods. This crosssectional study was conducted in 2021 and it included 71 breast cancer patients treated at the Department of Physical Medicine and Rehabilitation of the Oncology Institute of Vojvodina at the time of examination. The depression subscale of the Serbian version of the Depression, Anxiety and Stress Scale 21, assessing the degree of depression was used to assess depressive symptoms in the participants. The functional well-being was assessed using the Functional Well-Being subscale of the questionnaire for the Functional Assessment of Cancer Therapy - Breast. Results. A statistically significant correlation was found between depression and functional well-being (r = - 0.438, p < 0.001) of the examined patients. The results of the regression analysis showed that the F model was significant (F (1.69) = 16.366; p < 0.001) and showed 19.2% of the variance. Depression has a significant impact on the functional well-being of breast cancer patients (? = - 438, t = - 4.045, p < 0.001). Conclusion. Through a multidisciplinary approach, it is important to simultaneously functionally train breast cancer patients, but also to implement timely psychological support and rehabilitation.
介绍。在诊断出恶性疾病后，由于长期暴露于负面情绪和心理困扰，乳腺癌患者的心理状态往往受到损害，抑郁和焦虑等状况可能对乳腺癌患者的功能健康产生直接影响。这项研究的目的是研究抑郁症是否会影响乳腺癌患者的功能健康。材料和方法。这项横断面研究于2021年进行，其中包括在检查时在伏伊伏丁那肿瘤研究所物理医学和康复部接受治疗的71名乳腺癌患者。塞尔维亚版抑郁、焦虑和压力量表21的抑郁子量表评估抑郁程度，用于评估参与者的抑郁症状。功能幸福感采用乳腺癌治疗功能评估问卷的功能幸福感子量表进行评估。结果。被检查患者的抑郁与功能幸福感之间存在统计学显著相关(r = - 0.438, p < 0.001)。回归分析结果显示，F模型显著(F (1.69) = 16.366;P < 0.001)，方差为19.2%。抑郁症对乳腺癌患者的功能幸福感有显著影响(?= - 438, t = - 4.045, p < 0.001)。结论。通过多学科的方法，在对乳腺癌患者进行功能训练的同时，还要及时实施心理支持和康复。
{"title":"Effects of depression on the functional well-being of patients with breast cancer","authors":"Dajana Dedic, Aleksandra Kovac, S. Popović-Petrović, Ivana Zelic-Kozomora","doi":"10.2298/mpns2210290d","DOIUrl":"https://doi.org/10.2298/mpns2210290d","url":null,"abstract":"Introduction. The psychological status of patients with breast cancer is often compromised as a result of chronic exposure to negative emotions and psychological distress after the diagnosis of a malignant disease and conditions such as depression and anxiety may have a direct impact on the functional wellbeing of breast cancer patients. The aim of this study was to examine whether depression affects the functional well-being of breast cancer patients. Material and Methods. This crosssectional study was conducted in 2021 and it included 71 breast cancer patients treated at the Department of Physical Medicine and Rehabilitation of the Oncology Institute of Vojvodina at the time of examination. The depression subscale of the Serbian version of the Depression, Anxiety and Stress Scale 21, assessing the degree of depression was used to assess depressive symptoms in the participants. The functional well-being was assessed using the Functional Well-Being subscale of the questionnaire for the Functional Assessment of Cancer Therapy - Breast. Results. A statistically significant correlation was found between depression and functional well-being (r = - 0.438, p < 0.001) of the examined patients. The results of the regression analysis showed that the F model was significant (F (1.69) = 16.366; p < 0.001) and showed 19.2% of the variance. Depression has a significant impact on the functional well-being of breast cancer patients (? = - 438, t = - 4.045, p < 0.001). Conclusion. Through a multidisciplinary approach, it is important to simultaneously functionally train breast cancer patients, but also to implement timely psychological support and rehabilitation.","PeriodicalId":87940,"journal":{"name":"Calcutta medical review","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83537773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction. The main goal of wellness is to promote proactive and preventive behavior that improves mental health and lifestyle. This study examined how the lifestyle of respondents was affected by the inability to visit spas and wellness centers during the coronavirus disease 2019 pandemic. Material and Methods. This crosssectional study included a total of 186 participants with an average age of 41.31 ? 10.475 years, 137 female and 49 male. We specifically designed a questionnaire to analyze the impact of the lack of wellness services during the coronavirus disease 2019 pandemic. Results. There was no statistically significant association between gender, age, education, and marital status and visiting wellness destinations. Monthly income, however, showed a statistically significant association with visiting wellness facilities (p = 0.002). There was a significant decrease in the use of wellness centers during the coronavirus disease 2019 pandemic. A small number of the respondents believed the coronavirus disease 2019 pandemic has changed their lifestyle. Conclusion. The lack of wellness services has affected the respondents? inability to relax and get away from daily life, but the coronavirus disease 2019 pandemic has not negatively changed their lifestyle (p = 0.001).
{"title":"The impact of the coronavirus disease 2019 pandemic on wellness and healthy lifestyle","authors":"S. Djordjevic, S. Knežević, Nikola Savić","doi":"10.2298/mpns2208211d","DOIUrl":"https://doi.org/10.2298/mpns2208211d","url":null,"abstract":"Introduction. The main goal of wellness is to promote proactive and preventive behavior that improves mental health and lifestyle. This study examined how the lifestyle of respondents was affected by the inability to visit spas and wellness centers during the coronavirus disease 2019 pandemic. Material and Methods. This crosssectional study included a total of 186 participants with an average age of 41.31 ? 10.475 years, 137 female and 49 male. We specifically designed a questionnaire to analyze the impact of the lack of wellness services during the coronavirus disease 2019 pandemic. Results. There was no statistically significant association between gender, age, education, and marital status and visiting wellness destinations. Monthly income, however, showed a statistically significant association with visiting wellness facilities (p = 0.002). There was a significant decrease in the use of wellness centers during the coronavirus disease 2019 pandemic. A small number of the respondents believed the coronavirus disease 2019 pandemic has changed their lifestyle. Conclusion. The lack of wellness services has affected the respondents? inability to relax and get away from daily life, but the coronavirus disease 2019 pandemic has not negatively changed their lifestyle (p = 0.001).","PeriodicalId":87940,"journal":{"name":"Calcutta medical review","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84154363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Domić, Ivana Tomasovic, Paula Bernaciak, G. Voronov, R. Igić, R. Škrbić
Introduction. Combustible tobacco smoking accounts for nearly 30% of all cancer deaths in the United States of America and about 7 million deaths worldwide each year. Nowadays, e-cigarettes are increasingly used, especially among young people, but nicotine addiction that develops by such smoking easily converts to smoking combustible tobacco. Therefore, public health efforts must be directed to the prevention of initiation of smoking all nicotine-containing products. Role of Physicians. Medical doctors are very influential in smoking-related changes in local society, especially those who work in primary care, and they have an important role in both prevention and cessation of tobacco smoking. Tobacco smoking should be eliminated among medical doctors, yet many of them still smoke. The lowest percentage of smoking among physicians is in Oceania and North America (less than 11%) and the highest in Eurasia (25%). Smoking prevalence among medical students is higher than 35% in Georgia, Greece, Spain, and Italy, but less than 5% in the United States of America and Australia. In Serbia, 23% of physicians smoke. The age of physicians does not affect the number of smokers, but gender has a significant effect; women smoke less than men. Smoking Prevention and Cessation. Education about the effects of combustible tobacco smoking is a critical issue for successful smoking prevention and cessation; the best way is to provide educational programs on smoking at medical schools by introducing a mandatory course on combustible tobacco smoking at the beginning of the first year of study, especially in societies with a large percentage of smokers. Conclusion. In this paper, we showed how smoking can be eliminated among physicians and how they can affect the patients, public health policies, and antismoking campaigns.
{"title":"Role of physicians in eliminating risk of cancer caused by combustible tobacco smoke","authors":"A. Domić, Ivana Tomasovic, Paula Bernaciak, G. Voronov, R. Igić, R. Škrbić","doi":"10.2298/mpns2212363d","DOIUrl":"https://doi.org/10.2298/mpns2212363d","url":null,"abstract":"Introduction. Combustible tobacco smoking accounts for nearly 30% of all cancer deaths in the United States of America and about 7 million deaths worldwide each year. Nowadays, e-cigarettes are increasingly used, especially among young people, but nicotine addiction that develops by such smoking easily converts to smoking combustible tobacco. Therefore, public health efforts must be directed to the prevention of initiation of smoking all nicotine-containing products. Role of Physicians. Medical doctors are very influential in smoking-related changes in local society, especially those who work in primary care, and they have an important role in both prevention and cessation of tobacco smoking. Tobacco smoking should be eliminated among medical doctors, yet many of them still smoke. The lowest percentage of smoking among physicians is in Oceania and North America (less than 11%) and the highest in Eurasia (25%). Smoking prevalence among medical students is higher than 35% in Georgia, Greece, Spain, and Italy, but less than 5% in the United States of America and Australia. In Serbia, 23% of physicians smoke. The age of physicians does not affect the number of smokers, but gender has a significant effect; women smoke less than men. Smoking Prevention and Cessation. Education about the effects of combustible tobacco smoking is a critical issue for successful smoking prevention and cessation; the best way is to provide educational programs on smoking at medical schools by introducing a mandatory course on combustible tobacco smoking at the beginning of the first year of study, especially in societies with a large percentage of smokers. Conclusion. In this paper, we showed how smoking can be eliminated among physicians and how they can affect the patients, public health policies, and antismoking campaigns.","PeriodicalId":87940,"journal":{"name":"Calcutta medical review","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84733648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nataša Puškar, Milica Puskar, P. Vucinic, Stojan Ivić, D. Petrović
Introduction. Class III malocclusions are characterized by a more prominent lower jaw compared to the upper jaw and a Class III skeletal and dentoalveolar relationship according to Angle. In the scientific literature, there is a small amount of data on the morphological characteristics of malocclusion in different populations, so there is a justified need to examine the morphological characteristics of Class III malocclusion in the population of Vojvodina. The aim of this study was to determine the morphological characteristics of Class III malocclusions, to compare them with the average values found in the scientific literature, and to determine the correlation between the examined parameters of the upper and lower jaw. Material and Methods. This retrospective study included subjects with Class III dentoalveolar malocclusion treated at the Dentistry Clinic of Vojvodina in Novi Sad. The method of random selection was used to select 50 study models. The data were statistically processed with a significance level of p < 0.05. Results. The obtained results indicate that the sum of crown width of the mandibular incisors, the length of the mandibular dental arch, and the mandibular apical base in subjects with Class III malocclusion are higher than the average values in the general population. The values of the posterior width of the maxillary dental arch in the examined group are lower compared to the average values in the general population. Conclusion. Subjects with Class III malocclusion present with a greater mandibular dental arch in regard to the maxillary dental arch.
{"title":"Determination of dentoalveolar parameters in patients with progenia","authors":"Nataša Puškar, Milica Puskar, P. Vucinic, Stojan Ivić, D. Petrović","doi":"10.2298/mpns2210279p","DOIUrl":"https://doi.org/10.2298/mpns2210279p","url":null,"abstract":"Introduction. Class III malocclusions are characterized by a more prominent lower jaw compared to the upper jaw and a Class III skeletal and dentoalveolar relationship according to Angle. In the scientific literature, there is a small amount of data on the morphological characteristics of malocclusion in different populations, so there is a justified need to examine the morphological characteristics of Class III malocclusion in the population of Vojvodina. The aim of this study was to determine the morphological characteristics of Class III malocclusions, to compare them with the average values found in the scientific literature, and to determine the correlation between the examined parameters of the upper and lower jaw. Material and Methods. This retrospective study included subjects with Class III dentoalveolar malocclusion treated at the Dentistry Clinic of Vojvodina in Novi Sad. The method of random selection was used to select 50 study models. The data were statistically processed with a significance level of p < 0.05. Results. The obtained results indicate that the sum of crown width of the mandibular incisors, the length of the mandibular dental arch, and the mandibular apical base in subjects with Class III malocclusion are higher than the average values in the general population. The values of the posterior width of the maxillary dental arch in the examined group are lower compared to the average values in the general population. Conclusion. Subjects with Class III malocclusion present with a greater mandibular dental arch in regard to the maxillary dental arch.","PeriodicalId":87940,"journal":{"name":"Calcutta medical review","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81007922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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