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Functional and morphological maturation of the full-sized and mini-pig corpus luteum by programmed cell death mechanism. 通过程序性细胞死亡机制实现全尺寸黄体和迷你猪黄体的功能和形态成熟
IF 2.7 Pub Date : 2023-06-16 eCollection Date: 2023-06-01 DOI: 10.2478/jvetres-2023-0023
Ji-Hye Lee, Sang-Hwan Kim

Introduction: The formation and function of the corpus luteum (CL) increase the likelihood of pregnancy and efficiently manage implantation. Apoptosis must occur at an appropriate time in the formation of the CL. This also affects its function. However, it is still unclear if the type of apoptosis affects the function.

Material and methods: We conducted morphological analysis of the CL collected on day 15 between the middle and late oestrous phases of Yorkshire pigs and mini-pigs, and measured the difference in hormone expression and apoptosis using an immunoassay method and messenger RNA level.

Results: The CL cells were more uniform in the Yorkshire pigs than in the mini-pigs, and the composition of the CL was also fuller. The expression of luteinising hormone was higher in the Yorkshire pigs. Apoptosis and the rate of action of matrix metalloproteinases (MMPs) were different between the two pig types. Expression of MMPs was higher in the Yorkshire pigs than in the mini-pigs. However, the expression of caspase 3 and 20alpha-hydroxysteroid dehydrogenase, a progesterone inhibitor, was potentiated in the mini-pigs.

Conclusion: Autophagy throughout the CL was more extensive in the Yorkshire pigs than in the mini-pigs, suggesting that autophagy and cell reorganisation by MMPs were highly correlated. The occurrence of autophagy in the formation and function of the CL may affect the action of hormones and expression of cell reconstitution factors.

导言:黄体(CL)的形成和功能增加了怀孕的可能性,并有效地管理着床。黄体凋亡必须在黄体形成的适当时间发生。这也会影响其功能。然而,目前还不清楚凋亡的类型是否会影响其功能:我们对约克夏猪和迷你猪发情中期和晚期第 15 天采集的 CL 进行了形态学分析,并使用免疫测定法和信使 RNA 水平测定了激素表达和细胞凋亡的差异:约克夏猪的CL细胞比小型猪更均匀,CL的组成也更饱满。约克夏猪黄体生成素的表达量更高。两种猪的细胞凋亡和基质金属蛋白酶(MMPs)的作用率不同。约克夏猪的 MMPs 表达量高于小型猪。然而,在迷你猪体内,Caspase 3和20α-羟基类固醇脱氢酶(一种孕酮抑制剂)的表达得到了增强:结论:与迷你猪相比,约克夏猪整个CL中的自噬现象更为普遍,这表明自噬与MMPs导致的细胞重组高度相关。自噬在CL的形成和功能中的发生可能会影响激素的作用和细胞重组因子的表达。
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引用次数: 0
Procedural aspects that control discounting rates when using the fill-in-the-blank and multiple-choice methods 在使用填空法和多项选择法时控制贴现率的程序方面
Pub Date : 2014-07-01 DOI: 10.1037/H0101281
J. Weatherly, Kathryn A. Feltman, A. Derenne
The present study investigated if and why rates of delay or probability discounting would vary as a function of whether the data were collected using the fill-in-the-blank (FITB) or multiple-choice (MC) method. Participants in Experiment 1 completed a discounting task using either the FITB or MC met
本研究调查了延迟或概率折扣率是否以及为什么会随着数据是使用填空(FITB)还是选择题(MC)方法收集而变化。实验1的参与者使用FITB或MC会议完成了一个折扣任务
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引用次数: 2
Using SAFMEDS and direct instruction to teach the model of hierarchical complexity 使用safmed和直接指令来教授层次复杂性模型
Pub Date : 2014-07-01 DOI: 10.1037/H0101284
M. Commons, Darlene E. Crone-Todd, S. Chen
The model of hierarchical complexity (MHC) assesses a general, unidimensional behavioral developmental set of tasks and stages that measures difficulty across different domains. Teaching the model is a challenge because of the abstract nature of the model. Using traditional methods of lecturing to t
层次复杂性模型(MHC)评估了一套一般的、单维的行为发展任务和阶段,衡量了不同领域的难度。由于模型的抽象性,教授模型是一个挑战。用传统的方法讲课
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引用次数: 7
On the sequential and concurrent presentation of trials establishing prerequisites for emergent relations. 论审判的顺序和并行呈现为紧急关系建立先决条件。
Pub Date : 2014-07-01 DOI: 10.1037/H0101280
E. Arntzen, Lill-Beathe Halstadtro, E. Bjerke, Kristin Jonassen Wittner, Anette Kristiansen
One young man with autism was trained in botanical skills. He was trained to match different drawings of trees (c), shown with Their respective names (a), and tree leaves (b) using a conditional discrimination procedure. The conditional discrimination Procedures were arranged as a many-to-one traini
一个患有自闭症的年轻人接受了植物学技能的培训。他被训练去匹配不同的树图(c),分别显示它们各自的名字(a)和树叶(b),使用条件辨别程序。将条件歧视程序安排为多对一训练
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引用次数: 21
IncChains: A program written in Visual Basic® 2010 for studying variables affecting human learning. IncChains:一个用Visual Basic®2010编写的程序,用于研究影响人类学习的变量。
Pub Date : 2014-01-01 DOI: 10.1037/H0101283
Noah Sontz Dermer, M. Dermer, David M. Trejo
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引用次数: 0
The zeitgeist of behavior analytic research in the 21st century: A keyword analysis. 21世纪行为分析研究的时代精神:关键词分析。
Pub Date : 2014-01-01 DOI: 10.1037/H0101282
Derek D. Reed, Florence D. DiGennaro Reed, Sarah R. Jenkins, Jason M. Hirst
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引用次数: 4
The Relation between GPA and Exam Performance during Interteaching and Lecture. 教学与授课中GPA与考试成绩的关系。
Pub Date : 2012-06-22 DOI: 10.1037/H0100728
Bryan K. Saville, Derek A. Pope, J. Truelove, Jacob L. Williams
A growing number of studies have shown that interteaching produces better student-learning outcomes than more traditional teaching methods such as lecture. But to date, no studies have directly examined whether interteaching is differentially effective for students who typically earn either good or bad grades in their courses. In this study, we alternated between interteaching and lecture several times during the semester and measured the exam performance of students with low, moderate, and high grade point averages. We found that interteaching improved the exam scores for students in each of these groups but that the improvement was most noticeable for students with low and moderate GPAs. Thus, interteaching may be especially useful for students who typically earn lower grades in their courses.
越来越多的研究表明,互动教学比讲座等传统教学方法能产生更好的学生学习效果。但到目前为止,还没有研究直接检验过,对于那些通常在课程中取得好成绩或差成绩的学生,互动式教学是否有不同的效果。在本研究中,我们在学期中交替进行了几次教学和授课,并测量了平均成绩低、中、高的学生的考试成绩。我们发现,互动式教学提高了这两组学生的考试成绩,但这种提高对平均分较低和中等的学生最为明显。因此,互动式教学可能对那些通常在课程中取得较低成绩的学生特别有用。
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引用次数: 18
Gambling Behind the Walls: A Behavior-Analytic Perspective 墙后的赌博:行为分析的视角
Pub Date : 2012-06-22 DOI: 10.1037/H0100725
J. Weatherly, Kevin S. Montes, D. Peters, Alyssa. N. Wilson
The field of behavior analysis has done an excellent job of not only raising public awareness about certain disorders (e.g., Autism), but also developing the best treatments for those disorders. The field has not yet, however, done so for many behavioral disorders. For instance, pathological gambling is a major societal issue, but little behavior-analytic work has focused on it despite the fact that the disorder occurs at several times the frequency of other, more publicized, disorders such as Autism (Dixon, Marley, & Jacobs, 2003). One possible reason for the dearth of behavior-analytic research could be B.F. Skinner's (1953) conclusion that gambling behavior could be understood in terms of schedules of reinforcement. Subsequent research, however, suggests that multiple factors likely control gambling behavior (e.g., see Weatherly & Dixon, 2007). According to most prevalence studies, the rate of pathological gambling in the general population likely ranges between 1 -2% (see Petry, 2005, for a review). In terms of absolute numbers, these percentages represent millions of individuals in the United States alone. The numbers do not, however, encapsulate the problem. That is, pathological gamblers are individuals who officially meet diagnostic criteria according to the DSM-IV-TR (American Psychiatric Association, 2000). Other people are labeled as "problem gamblers" because they display some symptoms of pathological gambling, but not enough symptoms to be diagnosed clinically as pathological. The prevalence rates of problem gambling are also difficult to estimate, but it seems reasonable to conclude that the number of problem gamblers exceeds the number of pathological gamblers, possibly another 5% or more of the population (see Petry, 2005). Pathological gambling is currently classified as an impulse disorder that is not otherwise classified. (1) To meet diagnostic criteria for pathological gambling, an individual must display at least five of the ten possible symptoms. Three of these symptoms are generally considered "cognitive" in nature. The possible cognitive symptoms include a preoccupation with gambling, feeling the need to increase one's betting so as to maintain the original level of excitement or arousal, and feeling restless when one attempts to cease gambling. (2) Six of the remaining seven symptoms are descriptive of behaviors in which the gambler might engage. They are trying to cease gambling but failing, increasing one's betting in an attempt to win back what has been lost (i.e., chasing one's bet), lying to others so as to conceal one's gambling, engaging in illegal behavior to finance one's gambling, putting one's opportunities (e.g., job, personal relationships, etc.) in jeopardy because of continued gambling, and turning to other individuals to finance one's gambling or to address financial issues that have resulted from one's gambling. (3) Interestingly, only one of the official symptoms for pathological gambling specifically id
行为分析领域不仅在提高公众对某些疾病(如自闭症)的认识方面做得很好,而且在开发治疗这些疾病的最佳方法方面也做得很好。然而,该领域还没有对许多行为障碍进行这样的治疗。例如,病态赌博是一个主要的社会问题,但很少有行为分析工作关注它,尽管事实上这种疾病的发生频率是其他更广为人知的疾病(如自闭症)的几倍(Dixon, Marley, & Jacobs, 2003)。行为分析研究缺乏的一个可能原因可能是B.F. Skinner(1953)的结论,即赌博行为可以从强化时间表的角度来理解。然而,随后的研究表明,多种因素可能控制赌博行为(例如,参见Weatherly & Dixon, 2007)。根据大多数流行病学研究,一般人群的病态赌博率可能在1% -2%之间(见Petry, 2005年的综述)。就绝对数字而言,这些百分比仅在美国就代表了数百万人。然而,这些数字并不能概括问题。也就是说,病态赌徒是根据DSM-IV-TR(美国精神病学协会,2000)正式符合诊断标准的个体。还有一些人被贴上了“问题赌徒”的标签,因为他们表现出一些病态赌博的症状,但这些症状还不足以在临床上被诊断为病态。问题赌博的流行率也很难估计,但似乎可以合理地得出结论,问题赌徒的数量超过了病态赌徒的数量,可能占人口的5%或更多(见Petry, 2005)。病态赌博目前被归类为一种冲动障碍,没有其他分类。(1)要符合病态赌博的诊断标准,个人必须表现出十种可能症状中的至少五种。这些症状中的三种通常被认为是“认知”性质的。可能的认知症状包括对赌博的专注,感觉需要增加赌注以保持原来的兴奋或觉醒水平,以及当试图停止赌博时感到不安。(2)其余七个症状中的六个是对赌徒可能参与的行为的描述。他们试图停止赌博,但失败了,增加投注,试图赢回已经失去的东西(即追逐自己的赌注),向他人撒谎以隐瞒自己的赌博,从事非法行为以资助自己的赌博,将自己的机会(例如,工作,个人关系等)置于危险之中,因为继续赌博,转向其他人资助自己的赌博或解决因赌博而产生的财务问题。(3)有趣的是,病理性赌博的官方症状中只有一种明确指出了可能控制个人赌博行为的偶然性;这个人赌博作为一种逃避。因此,对于行为分析师来说,这种特殊的症状可能具有特殊的相关性,这一点可能并不奇怪,这将在本文的后面讨论。正如人们可以想象的那样,关于赌博的研究文献是巨大的(并且超出了本文回顾所有这些文献的范围),许多研究人员试图确定导致病态赌博的因素。不幸的是,绝大多数的研究本质上是相关的。因此,联想关系可以被识别,并且已经被识别。然而,这种疾病背后的因果机制还没有得到明确的确立。无论如何,研究已经潜在地确定了病态赌博的建立操作(Michael, 1993)或设置事件(Kantor & Smith, 1975)。正如Petry(2005)所概述的,病态赌博有六个主要风险因素,其中几个可能是相互关联的。…
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引用次数: 5
A Pilot Investigation Comparing Instructional Packages for MTS Training: "Manual Alone" vs. "Manual-Plus-Computer-Aided Personalized System of Instruction" 比较MTS培训教学包的试点调查:“单独手册”与“单独手册”。“人工+计算机辅助个性化教学系统”
Pub Date : 2012-06-22 DOI: 10.1037/H0100727
M. A. Oliveira, Celso Goyos, J. Pear
Matching-to-sample (MTS) training consists of presenting a stimulus as a sample followed by stimuli called comparisons from which a subject makes a choice. This study presents results of a pilot investigation comparing two packages for teach- ing university students to conduct MTS training. Two groups - control and experimental - with 2 participants in each group were used. Accuracy in conducting MTS training was assessed during baseline and post-training. During training the control group received a manual, and the experimental group received both the manual and computer-aided personalized system of instruction or CAPSI. Baseline and post-training combined scores for control and experimental groups were 72.5% and 100%, and 72.7% and 95%, respectively. Results showed that the manual and the manual-plus-CAPSI packages produced similar effects in delivering knowledge in MTS training. We suggest that future studies using a larger sample size are neces- sary. In addition, we suggest that it is necessary to test new versions of the manual and the interaction of CAPSI with other components, such as demonstration videos.
样本匹配(MTS)训练包括将刺激作为样本呈现,然后将刺激称为比较,受试者从中做出选择。本研究提出了一项试点调查的结果,比较两套教学方案的大学生进行MTS训练。对照组和实验组两组,每组2人。在基线和训练后评估进行MTS训练的准确性。在训练期间,对照组接受手册,实验组接受手册和计算机辅助个性化教学系统(CAPSI)。对照组和实验组的基线和训练后综合得分分别为72.5%和100%,72.7%和95%。结果表明,在MTS培训中,手册和手册加capsi包在传递知识方面产生了相似的效果。我们建议未来有必要进行更大样本量的研究。此外,我们建议有必要测试新版本的手册以及CAPSI与其他组件(如演示视频)的交互。
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引用次数: 7
Prisoner Reentry and Recidivism According to the Formerly Incarcerated and Reentry Service Providers: A Verbal Behavior Approach 根据前监禁和再入服务提供者的囚犯再入和再犯:一种言语行为方法
Pub Date : 2012-06-22 DOI: 10.1037/H0100726
S. W. Bowman, Raphael Travis
Successful reintegration of formerly incarcerated individuals into communities is important because of both the personal and emotional costs to the former offender and the social and financial costs to the community and criminal justice system. Prior research examining reentry success has used structural and psychological explanations for better understanding the processes that contribute to recidivism. Using B.F. Skinner’s (1957) Theory of Verbal Behavior as a theoretical foundation, twelve focus groups totaling 128 formerly incarcerated persons and reentry service providers were conducted that explored perspectives of the current reentry system, views on recidivism, and opportunities for improvement. Results indicate that a Verbal Behavior approach enhances the understanding of reentry when examined as a metacontingency with a goal of a particular outcome. Implications for reentry intervention are discussed.
成功地使曾经被监禁的人重新融入社区是很重要的,因为前罪犯的个人和情感成本以及社区和刑事司法系统的社会和经济成本。为了更好地理解导致再犯的过程,先前对再入成功与否的研究使用了结构和心理学的解释。以斯金纳(B.F. Skinner, 1957)的言语行为理论为理论基础,对12个焦点小组进行了研究,共128名前囚犯和再入社会服务提供者,探讨了当前再入社会制度的观点、对再犯的看法以及改进的机会。结果表明,言语行为方法提高了对再入的理解,当被视为具有特定结果目标的元偶然性时。对重返社会干预的影响进行了讨论。
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引用次数: 16
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The behavior analyst today
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