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Statement of Retraction: miR-134-5p promotes inflammation and apoptosis of trophoblast cells via regulating FOXP2 transcription in gestational diabetes mellitus 撤回声明:miR-134-5p 通过调控 FOXP2 转录促进妊娠糖尿病滋养细胞的炎症和凋亡
IF 4.9 4区 生物学 Q2 Biochemistry, Genetics and Molecular Biology Pub Date : 2024-02-20 DOI: 10.1080/21655979.2024.2299586
Published in Bioengineered (Vol. 15, No. 1, 2024)
发表于《生物工程》(第 15 卷第 1 期,2024 年)
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引用次数: 0
Statement of Retraction: MicroRNA-4521 targets hepatoma up-regulated protein (HURP) to inhibit the malignant progression of breast cancer 撤回声明:MicroRNA-4521靶向肝癌上调蛋白(HURP)抑制乳腺癌的恶性进展
IF 4.9 4区 生物学 Q2 Biochemistry, Genetics and Molecular Biology Pub Date : 2024-01-29 DOI: 10.1080/21655979.2024.2302649
Published in Bioengineered (Vol. 15, No. 1, 2024)
发表于《生物工程》(第 15 卷第 1 期,2024 年)
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引用次数: 0
Engineered yeasts and lignocellulosic biomaterials: shaping a new dimension for biorefinery and global bioeconomy. 工程酵母和木质纤维素生物材料:为生物炼制和全球生物经济塑造新的维度。
IF 4.9 4区 生物学 Q2 Biochemistry, Genetics and Molecular Biology Pub Date : 2023-12-01 Epub Date: 2023-10-18 DOI: 10.1080/21655979.2023.2269328
Michael Dare Asemoloye, Tunde Sheriffdeen Bello, Peter Olusakin Oladoye, Muideen Remilekun Gbadamosi, Segun Oladiran Babarinde, Gboyega Ebenezer Adebami, Olumayowa Mary Olowe, Marta Elisabetta Eleonora Temporiti, Wolfgang Wanek, Mario Andrea Marchisio

The next milestone of synthetic biology research relies on the development of customized microbes for specific industrial purposes. Metabolic pathways of an organism, for example, depict its chemical repertoire and its genetic makeup. If genes controlling such pathways can be identified, scientists can decide to enhance or rewrite them for different purposes depending on the organism and the desired metabolites. The lignocellulosic biorefinery has achieved good progress over the past few years with potential impact on global bioeconomy. This principle aims to produce different bio-based products like biochemical(s) or biofuel(s) from plant biomass under microbial actions. Meanwhile, yeasts have proven very useful for different biotechnological applications. Hence, their potentials in genetic/metabolic engineering can be fully explored for lignocellulosic biorefineries. For instance, the secretion of enzymes above the natural limit (aided by genetic engineering) would speed-up the down-line processes in lignocellulosic biorefineries and the cost. Thus, the next milestone would greatly require the development of synthetic yeasts with much more efficient metabolic capacities to achieve basic requirements for particular biorefinery. This review gave comprehensive overview of lignocellulosic biomaterials and their importance in bioeconomy. Many researchers have demonstrated the engineering of several ligninolytic enzymes in heterologous yeast hosts. However, there are still many factors needing to be well understood like the secretion time, titter value, thermal stability, pH tolerance, and reactivity of the recombinant enzymes. Here, we give a detailed account of the potentials of engineered yeasts being discussed, as well as the constraints associated with their development and applications.

合成生物学研究的下一个里程碑依赖于为特定工业目的开发定制微生物。例如,一个生物体的代谢途径描述了它的化学库和基因组成。如果控制这些途径的基因能够被识别,科学家可以决定根据生物体和所需的代谢产物,为不同的目的增强或重写它们。木质纤维素生物炼制在过去几年中取得了良好的进展,对全球生物经济产生了潜在的影响。该原理旨在通过微生物作用从植物生物质中生产不同的生物基产品,如生物化学或生物燃料。同时,酵母已被证明在不同的生物技术应用中非常有用。因此,它们在遗传/代谢工程中的潜力可以在木质纤维素生物炼制中得到充分探索。例如,超过天然极限的酶的分泌(在基因工程的帮助下)将加快木质纤维素生物精炼厂的下游过程和成本。因此,下一个里程碑将极大地需要开发具有更有效代谢能力的合成酵母,以实现特定生物炼制的基本要求。综述了木质纤维素生物材料及其在生物经济中的重要性。许多研究人员已经证明了几种木质素分解酶在异源酵母宿主中的工程化。然而,仍有许多因素需要充分了解,如分泌时间、滴度、热稳定性、pH耐受性和重组酶的反应性。在这里,我们详细介绍了正在讨论的工程酵母的潜力,以及与它们的开发和应用相关的限制因素。
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引用次数: 0
Column-based removal of high concentration microplastics in synthetic wastewater using granular activated carbon. 颗粒活性炭柱法去除合成废水中的高浓度微塑料。
IF 4.9 4区 生物学 Q2 Biochemistry, Genetics and Molecular Biology Pub Date : 2023-12-01 Epub Date: 2023-11-09 DOI: 10.1080/21655979.2023.2276391
Nik Nor Amirah Mohd Napi, Naimah Ibrahim, Muhammad Adli Hanif, Masitah Hasan, Farrah Aini Dahalan, Achmad Syafiuddin, Raj Boopathy

Microplastic (MP) is an emerging contaminant of concern due to its abundance in the environment. Wastewater treatment plant (WWTP) can be considered as one of the main sources of microplastics in freshwater due to its inefficiency in the complete removal of small MPs. In this study, a column-based MP removal which could serve as a tertiary treatment in WWTPs is evaluated using granular activated carbon (GAC) as adsorbent/filter media, eliminating clogging problems commonly caused by powder form activated carbon (PAC). The GAC is characterized via N2 adsorption-desorption isotherm, field emission scanning electron microscopy, and contact angle measurement to determine the influence of its properties on MP removal efficiency. MPs (40-48 μm) removal up to 95.5% was observed with 0.2 g/L MP, which is the lowest concentration tested in this work, but still higher than commonly used MP concentration in other studies. The performance is reduced with further increase in MP concentration (up to 1.0 g/L), but increasing the GAC bed length from 7.5 to 17.5 cm could lead to better removal efficiencies. MP particles are immobilized by the GAC predominantly by filtration process by being entangled with small GAC particles/chips or stuck between the GAC particles. MPs are insignificantly removed by adsorption process through entrapment in GAC porous structure or attachment onto the GAC surface.

微塑料(MP)由于其在环境中的丰富性而成为一种新出现的令人担忧的污染物。污水处理厂(WWTP)可被认为是淡水中微塑料的主要来源之一,因为它在完全去除小MP方面效率低下。在本研究中,使用颗粒活性炭(GAC)作为吸附剂/过滤介质,评估了可作为污水处理厂三级处理的柱状MP去除,消除了粉末状活性炭(PAC)常见的堵塞问题。通过N2吸附-解吸等温线、场发射扫描电子显微镜和接触角测量对GAC进行表征,以确定其性质对MP去除效率的影响。议员(40-48 μm)去除率高达95.5% g/L MP,这是本工作中测试的最低浓度,但仍高于其他研究中常用的MP浓度。MP浓度进一步增加(最高1.0 g/L),但将GAC床长从7.5增加到17.5 cm可以导致更好的去除效率。MP颗粒主要通过与小的GAC颗粒/芯片纠缠或粘附在GAC颗粒之间的过滤过程被GAC固定。MPs通过截留在GAC多孔结构中或附着在GAC表面的吸附过程被不显著地去除。
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引用次数: 0
GXMR-CAR containing distinct GXM-specific single-chain variable fragment (scFv) mediated the cell activation against Cryptococcus spp. And had difference in the strength of tonic signaling. 含有不同gxm特异性单链可变片段(scFv)的GXMR-CAR介导了细胞对隐球菌的激活,并且在强直信号的强度上存在差异。
IF 4.9 4区 生物学 Q2 Biochemistry, Genetics and Molecular Biology Pub Date : 2023-12-01 Epub Date: 2023-11-18 DOI: 10.1080/21655979.2023.2281059
Michele Procópio Machado, Matheus Henrique Dos Santos, Júlia Garcia Guimarães, Gabriela Yamazaki de Campos, Patrícia Kellen Martins Oliveira Brito, Camilly Melo Garcia Ferreira, Caroline Patini Rezende, Natália Fernandes Frota, Sandro Gomes Soares, Pappanaicken R Kumaresan, Marcos Roberto Lourenzoni, Thiago Aparecido da Silva

Cryptococcus spp. has a polysaccharide capsule composed of glucuronoxylomannan-GXM, a major virulence factor that can prevent the recognition of fungi by immune cells. Chimeric Antigen Receptor (CAR) redirects T cells to target Cryptococcus spp. as previously demonstrated by a CAR specific to GXM, GXMR-CAR. The current study evaluated the strength of the signal transduction triggered by GXMR-CAR, composed of a distinct antigen-binding domain sourced from a single-chain variable fragment (scFv). GXM-specific scFv derived from mAbs 2H1 and 18B7, 2H1-GXMR-CAR and 18B7-GXMR-CAR, respectively, were designed to express CD8 molecule as hinge/transmembrane, and the costimulatory molecule CD137 (4-1BB) coupled to CD3ζ. The 2H1-GXMR-CAR or 18B7-GXMR-CAR Jurkat cells recognized soluble GXM from C. gattii and C. neoformans, and the levels of IL-2 released by the modified cells did not differ between the GXMR-CAR constructs after exposure to Cryptococcus spp. 18B7-GXMR-CAR triggered tonic signaling was more pronounced in modified Jurkat cells, and a protein kinase inhibitor of the Src family (dasatinib) significantly reduced GXMR-CAR tonic signaling and inhibited cell activation against ligands. 18B7 scFv showed a structural modification of the variable heavy (VH) chain that clarified the difference in the strength of tonic signaling and the level of cell activation between 2H1-GXMR-CAR and 18B7-GXMR-CAR. GXMR-CAR constructs induced T-cell activation against clinical isolates of Cryptococcus spp. and serum from patients with cryptococcosis induced high levels of IL-2, mainly in cells modified with 18B7-GXMR-CAR. Thus, 18B7-GXMR-CAR and 2H1-GXMR-CAR mediated T cell activation against Cryptococcus spp. and 18B7 and 2H1 scFv influenced the strength of tonic signaling.

隐球菌(Cryptococcus sp .)有一种由葡萄糖醛酸甘露聚糖(glucuronoxylromanan - gxm)组成的多糖胶囊,这是一种主要的毒力因子,可以阻止免疫细胞对真菌的识别。嵌合抗原受体(Chimeric Antigen Receptor, CAR)可将T细胞重定向到隐球菌(Cryptococcus),如先前的GXM特异性CAR (GXMR-CAR)所证明的那样。目前的研究评估了GXMR-CAR触发的信号转导强度,该信号转导由来自单链可变片段(scFv)的独特抗原结合域组成。分别由单克隆抗体2H1和18B7, 2H1- gxmr - car和18B7- gxmr - car衍生的gxm特异性scFv被设计为表达CD8分子作为铰链/跨膜,共刺激分子CD137 (4-1BB)偶联于CD3ζ。2H1-GXMR-CAR或18B7-GXMR-CAR Jurkat细胞识别来自C. gtii和C. neoformans的可溶性GXM,并且暴露于隐球菌后,修饰细胞释放的IL-2水平在修饰的GXMR-CAR结构之间没有差异。18B7-GXMR-CAR触发的补补信号在修饰的Jurkat细胞中更为明显,Src家族的蛋白激酶抑制剂(达沙替尼)显着减少GXMR-CAR补补信号并抑制细胞对配体的激活。18B7 scFv显示可变重链(VH)的结构修饰,澄清了2H1-GXMR-CAR和18B7- gxmr - car之间强直信号强度和细胞激活水平的差异。GXMR-CAR构建了针对隐球菌临床分离株和隐球菌患者血清诱导高水平IL-2的诱导t细胞活化,主要在18B7-GXMR-CAR修饰的细胞中。因此,18B7- gxmr - car和2H1- gxmr - car介导的T细胞对隐球菌和18B7和2H1 scFv的激活影响了补品信号的强度。
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引用次数: 0
Thermochemical behavior of agricultural and industrial sugarcane residues for bioenergy applications. 用于生物能源应用的农业和工业甘蔗残基的热化学行为。
IF 4.9 4区 生物学 Q2 Biochemistry, Genetics and Molecular Biology Pub Date : 2023-12-01 Epub Date: 2023-11-20 DOI: 10.1080/21655979.2023.2283264
Karen Lorena Martinez-Mendoza, Juan Guerrero-Perez, Juan Barraza-Burgos, Carmen Rosa Forero, Orla Williams, Edward Lester, Nicolas Gil

The Colombian sugarcane industry yields significant residues, categorized as agricultural and industrial. While bagasse, a widely studied industrial residue, is employed for energy recovery through combustion, agricultural residues are often left in fields. This study assesses the combustion behavior of these residues in typical collection scenarios. Additionally, it encompasses the characterization of residues from genetically modified sugarcane varieties in Colombia, potentially exhibiting distinct properties not previously documented. Non-isothermal thermogravimetrical analysis was employed to study the thermal behavior of sugarcane industrial residues (bagasse and pith) alongside agricultural residues from two different sugarcane varieties. This facilitated the determination of combustion reactivity through characteristic combustion process temperatures and technical parameters like ignition and combustion indexes. Proximate, elemental, and biochemical analyses revealed slight compositional differences. Agricultural residues demonstrated higher ash content (up to 34%) due to foreign matter adhering during harvesting, as well as soil and mud attachment during collection. Lignin content also varied, being lower for bagasse and pith, attributed to the juice extraction and milling processes that remove soluble lignin. Thermogravimetric analysis unveiled a two-stage burning process in all samples: devolatilization and char formation (~170°C), followed by char combustion (~310°C). Characteristic temperatures displayed subtle differences, with agricultural residues exhibiting lower temperatures and decomposition rates, resulting in reduced ignition and combustion indexes. This indicates heightened combustion reactivity in industrial residues, attributed to their elevated oxygen percentage, leading to more reactive functional groups and greater combustion stability compared to agricultural residues. This information is pertinent for optimizing sugarcane residues utilization in energy applications.

哥伦比亚的甘蔗工业产生大量的残留物,分类为农业和工业。甘蔗渣是一种被广泛研究的工业废渣,它被用于通过燃烧回收能量,而农业废渣通常留在田地里。本研究评估了这些残留物在典型收集场景下的燃烧行为。此外,它还包括哥伦比亚转基因甘蔗品种残留的特征,可能显示出以前没有记录的独特特性。采用非等温热重分析方法研究了两种不同甘蔗品种的工业废渣(甘蔗渣和蔗髓)和农业废渣的热行为。这便于通过燃烧过程特征温度和点火、燃烧指标等技术参数测定燃烧反应性。近似的、元素的和生化的分析显示了轻微的成分差异。农业残留物显示出较高的灰分含量(高达34%),这是由于收获过程中异物的附着,以及收集过程中土壤和泥浆的附着。木质素含量也有所不同,甘蔗渣和木髓的木质素含量较低,这是由于榨汁和碾磨过程中去除了可溶性木质素。热重分析揭示了所有样品的两阶段燃烧过程:脱挥发和炭形成(~170°C),然后是炭燃烧(~310°C)。特征温度表现出细微的差异,农业残留物表现出较低的温度和分解速率,导致点火和燃烧指数降低。这表明工业残留物的燃烧反应性增强,归因于它们的高氧百分比,导致与农业残留物相比,更多的活性官能团和更好的燃烧稳定性。这一信息对于优化甘蔗秸秆在能源应用中的利用具有重要意义。
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引用次数: 0
Advances, trends and challenges in the use of biochar as an improvement strategy in the anaerobic digestion of organic waste: a systematic analysis. 利用生物炭作为有机废物厌氧消化改进策略的进展、趋势和挑战:系统分析。
IF 4.2 4区 生物学 Q2 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Pub Date : 2023-12-01 DOI: 10.1080/21655979.2023.2252191
Brayan Alexis Parra-Orobio, Jonathan Soto-Paz, Edgar Ricardo Oviedo-Ocaña, Seyed Alireza Vali, Antoni Sánchez

A recently strategy applied to anaerobic digestion (AD) is the use of biochar (BC) obtained from the pyrolysis of different organic waste. The PRISMA protocol-based review of the most recent literature data from 2011-2022 was used in this study. The review focuses on research papers from Scopus® and Web of Knowledge®. The review protocol used permits to identify 169 articles. The review indicated a need for further research in the following challenges on the application of BC in AD: i) to increase the use of BC in developing countries, which produce large and diverse amounts of waste that are the source of production of this additive; ii) to determine the effect of BC on the AD of organic waste under psychrophilic conditions; iii) to apply tools of machine learning or robust models that allow the process optimization; iv) to perform studies that include life cycle and technical-economic analysis that allow identifying the potential of applying BC in AD in large-scale systems; v) to study the effects of BC on the agronomic characteristics of the digestate once it is applied to the soil and vi) finally, it is necessary to deepen in the effect of BC on the dynamics of nitrogen and microbial consortia that affect AD, considering the type of BC used. In the future, it is necessary to search for new solutions in terms of the transport phenomena that occurs in AD with the use of BC using robust and precise mathematical models at full-scale conditions.

最近应用于厌氧消化(AD)的一种策略是使用从不同有机废物的热解中获得的生物炭(BC)。本研究使用了基于PRISMA协议的2011-2022年最新文献数据综述。综述的重点是Scopus®和Web of Knowledge®的研究论文。审查协议使用许可证来识别169篇文章。审查表明,有必要进一步研究BC在AD中的应用面临的以下挑战:一)在发展中国家增加BC的使用,这些国家产生了大量多样的废物,这些废物是这种添加剂的生产来源;ii)在嗜冷条件下测定BC对有机废物AD的影响;iii)应用允许过程优化的机器学习工具或鲁棒模型;iv)进行包括生命周期和技术经济分析在内的研究,以确定在大规模系统中应用BC的潜力;v) 研究BC在施用到土壤中后对消化物农艺特性的影响,以及vi)最后,考虑到所使用的BC类型,有必要加深BC对影响AD的氮和微生物群落动力学的影响。未来,有必要在全尺寸条件下使用稳健和精确的数学模型,通过使用BC,就AD中发生的传输现象寻找新的解决方案。
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引用次数: 0
Statement of Retraction: Methyl-CpG-binding protein 2 promotes osteogenic differentiation of bone marrow mesenchymal stem cells through regulating forkhead box F1/Wnt/β-Catenin axis. 撤回声明:甲基CpG结合蛋白2通过调节叉头盒F1/Wnt/β-儿茶素轴促进骨髓间充质干细胞的成骨分化。
IF 4.9 4区 生物学 Q2 Biochemistry, Genetics and Molecular Biology Pub Date : 2023-12-01 Epub Date: 2023-10-18 DOI: 10.1080/21655979.2023.2269350
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引用次数: 0
Health effects of herbicides and its current removal strategies. 除草剂对健康的影响及其目前的清除策略。
IF 4.9 4区 生物学 Q2 Biochemistry, Genetics and Molecular Biology Pub Date : 2023-12-01 Epub Date: 2023-09-25 DOI: 10.1080/21655979.2023.2259526
Rozidaini Mohd Ghazi, Nik Raihan Nik Yusoff, Nurul Syazana Abdul Halim, Ikarastika Rahayu Abdul Wahab, Nurzila Ab Latif, Siti Halimah Hasmoni, Muhammad Abbas Ahmad Zaini, Zainul Akmar Zakaria

The continually expanding global population has necessitated increased food supply production. Thus, agricultural intensification has been required to keep up with food supply demand, resulting in a sharp rise in pesticide use. The pesticide aids in the prevention of potential losses caused by pests, plant pathogens, and weeds, but excessive use over time has accumulated its occurrence in the environment and subsequently rendered it one of the emerging contaminants of concern. This review highlights the sources and classification of herbicides and their fate in the environment, with a special focus on the effects on human health and methods to remove herbicides. The human health impacts discussion was in relation to toxic effects, cell disruption, carcinogenic impacts, negative fertility effects, and neurological impacts. The removal treatments described herein include physicochemical, biological, and chemical treatment approaches, and advanced oxidation processes (AOPs). Also, alternative, green, and sustainable treatment options were discussed to shed insight into effective treatment technologies for herbicides. To conclude, this review serves as a stepping stone to a better environment with herbicides.

不断扩大的全球人口需要增加粮食供应生产。因此,农业集约化被要求跟上粮食供应需求,导致农药使用量急剧增加。杀虫剂有助于防止害虫、植物病原体和杂草造成的潜在损失,但随着时间的推移,过度使用会在环境中累积,并随后使其成为新出现的令人担忧的污染物之一。这篇综述强调了除草剂的来源、分类及其在环境中的命运,特别关注对人类健康的影响和清除除草剂的方法。人类健康影响的讨论涉及毒性影响、细胞破坏、致癌影响、负面生育影响和神经系统影响。本文所述的去除处理包括物理化学、生物和化学处理方法以及高级氧化工艺(AOPs)。此外,还讨论了替代、绿色和可持续的处理方案,以深入了解除草剂的有效处理技术。总之,这篇综述是用除草剂创造更好环境的垫脚石。
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引用次数: 0
Application of tissue engineering techniques in tracheal repair: a bibliometric study. 组织工程技术在气管修复中的应用:文献计量学研究。
IF 4.9 4区 生物学 Q2 Biochemistry, Genetics and Molecular Biology Pub Date : 2023-12-01 Epub Date: 2023-11-06 DOI: 10.1080/21655979.2023.2274150
Xiangyu Xu, Zhiming Shen, Yibo Shan, Fei Sun, Yi Lu, Jianwei Zhu, Yiqi Sun, Hongcan Shi

Transplantation of tissue-engineered trachea is an effective treatment for long-segment tracheal injury. This technology avoids problems associated with a lack of donor resources and immune rejection, generating an artificial trachea with good biocompatibility. To our knowledge, a systematic summary of basic and clinical research on tissue-engineered trachea in the last 20 years has not been conducted. Here, we analyzed the development trends of tissue-engineered trachea research by bibliometric means and outlined the future perspectives in this field. The Web of Science portal was selected as the data source. CiteSpace, VOSviewer, and the Bibliometric Online Analysis Platform were used to analyze the number of publications, journals, countries, institutions, authors, and keywords from 475 screened studies. Between 2000 and 2023, the number of published studies on tissue-engineered trachea has been increasing. Biomaterials published the largest number of papers. The United States and China have made the largest contributions to this field. University College London published the highest number of studies, and the most productive researcher was an Italian scholar, Paolo Macchiarini. However, close collaborations between various researchers and institutions from different countries were generally lacking. Despite this, keyword analysis showed that manufacturing methods for tracheal stents, hydrogel materials, and 3D bioprinting technology are current popular research topics. Our bibliometric study will help scientists in this field gain an in-depth understanding of the current research progress and development trends to guide their future work, and researchers in related fields will benefit from the introduction to transplantation methods of tissue-engineered trachea.

组织工程气管移植是治疗长段气管损伤的有效方法。这项技术避免了与缺乏供体资源和免疫排斥相关的问题,产生了具有良好生物相容性的人工气管。据我们所知,最近20年组织工程气管的基础和临床研究的系统总结 多年来一直没有进行。在此,我们通过文献计量学的方法分析了组织工程气管研究的发展趋势,并概述了该领域的未来前景。科学网门户网站被选为数据来源。CiteSpace、VOSviewer和文献计量在线分析平台用于分析475项筛选研究的出版物、期刊、国家、机构、作者和关键词的数量。2000年至2023年间,发表的关于组织工程气管的研究数量一直在增加。《生物材料》发表的论文数量最多。美国和中国在这一领域做出了最大贡献。伦敦大学学院发表的研究数量最多,最有成效的研究者是意大利学者Paolo Macchiarini。然而,来自不同国家的各种研究人员和机构之间普遍缺乏密切合作。尽管如此,关键词分析表明,气管支架的制造方法、水凝胶材料和3D生物打印技术是当前流行的研究课题。我们的文献计量学研究将帮助该领域的科学家深入了解当前的研究进展和发展趋势,以指导他们未来的工作,相关领域的研究人员将受益于组织工程气管移植方法的介绍。
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引用次数: 0
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