Pub Date : 2020-01-01DOI: 10.35841/GENETIC-ENGINEERING.3.1.1
Gazi Abdullah
Innovation of hereditary changing is an elective method to improve both the quality and the amount of rural items. Hereditarily Modified Organism (GMO) as the result of new innovation requires a fantastic administration methodologies particularly for the biosafety of the items before being discharged and popularized. This investigation means to decide the arrangement needs in settling on the correct choices so as to deal with a feasible GMO while diminishing the symptoms of this innovation to the earth and human wellbeing. The yields of strategy making dependent on specialists legitimization are separated into four (4) levels, they are: Focus, Factor, Criteria and Alternative ways level. The integrated of specialists legitimizations on natural, monetary, social and mechanical variables, give an almost equivalent Eigen esteems to the past four levels, so they are finished up in having a similar need in overseeing GMO. The quality progression of GMO harvest to non GMO crop is the most significant component to be considered with the Eigen esteems 0.278. The expansion of rancher’s pay with Eigen esteems 0.358 is considered as the most significant models of monetary factor. GMO wellbeing to human wellbeing (0.464) is the favoured social components. To wrap things up, the human asset capacity in doing biosafety test (0.580) is the most significant rules for the innovation factor. In light of the choices gathered by the specialists, law authorization components of the principles must be finished by 0.187 Eigen esteems contrasted and different other options. Additionally dependent on ISM (Interpretative Structural Modelling) quadrant network, elective components are dissipated into three quadrants; reliance, linkage and autonomous
{"title":"Review: Policy Analysis of Sustainable GMO Management","authors":"Gazi Abdullah","doi":"10.35841/GENETIC-ENGINEERING.3.1.1","DOIUrl":"https://doi.org/10.35841/GENETIC-ENGINEERING.3.1.1","url":null,"abstract":"Innovation of hereditary changing is an elective method to improve both the quality and the amount of rural items. Hereditarily Modified Organism (GMO) as the result of new innovation requires a fantastic administration methodologies particularly for the biosafety of the items before being discharged and popularized. This investigation means to decide the arrangement needs in settling on the correct choices so as to deal with a feasible GMO while diminishing the symptoms of this innovation to the earth and human wellbeing. The yields of strategy making dependent on specialists legitimization are separated into four (4) levels, they are: Focus, Factor, Criteria and Alternative ways level. The integrated of specialists legitimizations on natural, monetary, social and mechanical variables, give an almost equivalent Eigen esteems to the past four levels, so they are finished up in having a similar need in overseeing GMO. The quality progression of GMO harvest to non GMO crop is the most significant component to be considered with the Eigen esteems 0.278. The expansion of rancher’s pay with Eigen esteems 0.358 is considered as the most significant models of monetary factor. GMO wellbeing to human wellbeing (0.464) is the favoured social components. To wrap things up, the human asset capacity in doing biosafety test (0.580) is the most significant rules for the innovation factor. In light of the choices gathered by the specialists, law authorization components of the principles must be finished by 0.187 Eigen esteems contrasted and different other options. Additionally dependent on ISM (Interpretative Structural Modelling) quadrant network, elective components are dissipated into three quadrants; reliance, linkage and autonomous","PeriodicalId":89733,"journal":{"name":"Advancements in genetic engineering","volume":"167 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70040032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.35248/21690111.2020.9.160
R. Ofoe
World population is estimated by 2050 to reach 9.7 billion with large proportion concentrated in the developing countries. This increase in population will result in high demand for food which can be achieved through improved breeding of crops coupled with the adoption of genetic modification in Agriculture. However, great opposition in several countries advocated by Green Movement impedes the acceptance and adoption of genetically modified foods. This opposition is backed by environmental, political, economic and psychological motivations. Identifying the bases of these motivations will go a long way to boost the acceptance and adoption of genetic modification in Agriculture.
{"title":"Opposition to Genetic Modification in Agriculture: Green Movements Motivations","authors":"R. Ofoe","doi":"10.35248/21690111.2020.9.160","DOIUrl":"https://doi.org/10.35248/21690111.2020.9.160","url":null,"abstract":"World population is estimated by 2050 to reach 9.7 billion with large proportion concentrated in the developing countries. This increase in population will result in high demand for food which can be achieved through improved breeding of crops coupled with the adoption of genetic modification in Agriculture. However, great opposition in several countries advocated by Green Movement impedes the acceptance and adoption of genetically modified foods. This opposition is backed by environmental, political, economic and psychological motivations. Identifying the bases of these motivations will go a long way to boost the acceptance and adoption of genetic modification in Agriculture.","PeriodicalId":89733,"journal":{"name":"Advancements in genetic engineering","volume":"9 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69998305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.35248/21690111.2020.9.161
S. Withanage, Kladko Daniil
The involvement of genetic engineering techniques in the development of novel biomaterials has a huge impact on a vast range of applications. The capability of new genetically engineered material has achieved various innovative scopes in the biomedical industry. Such materials are usually designed via chemical and physical methods of genetic engineering. According to the genetic basis of sequence, molecular weight, folded structure, and stereochemistry, protein polymers thus suggest a generous view for the architecture of protein-based genetically engineered biomaterials. The scopes of developing genetically engineered biomaterials are leading to improve biological features of materials which can enhance the applicability and properties of materials. In the last five years, Genetic engineering research is becoming closer to the mass consumer. Leading global geneticists predict that in the coming years, a boom will occur in the genetic engineering market, comparable to the massive spread of personal computers in the 1980s.Thus genetically modified biomaterials with upgraded biological properties, expanding towards mass-scale industrial production, and the considerable consumption in regular universal activities. The techniques used to develop new materials and to modify the properties of existing materials, are subjected to different industries and fields of scientific researches.CRISPR is anauthoritative research tool that facilitates scientists to deal with the expression of a gene. It has shown tremendous potential in genome research due to its ability to delete unwanted traits, and possibly even replace them with desirable traits. It is agile, worthwhile, and more authentic than any preceding gene-editing techniques. Genetically engineered biomaterials have been an enormous field of research over the last fifteen years and CRISPR has already initiated performing a significant aspect in boosting biomaterial research.
{"title":"Genetically Engineered Biomaterials","authors":"S. Withanage, Kladko Daniil","doi":"10.35248/21690111.2020.9.161","DOIUrl":"https://doi.org/10.35248/21690111.2020.9.161","url":null,"abstract":"The involvement of genetic engineering techniques in the development of novel biomaterials has a huge impact on a vast range of applications. The capability of new genetically engineered material has achieved various innovative scopes in the biomedical industry. Such materials are usually designed via chemical and physical methods of genetic engineering. According to the genetic basis of sequence, molecular weight, folded structure, and stereochemistry, protein polymers thus suggest a generous view for the architecture of protein-based genetically engineered biomaterials. The scopes of developing genetically engineered biomaterials are leading to improve biological features of materials which can enhance the applicability and properties of materials. In the last five years, Genetic engineering research is becoming closer to the mass consumer. Leading global geneticists predict that in the coming years, a boom will occur in the genetic engineering market, comparable to the massive spread of personal computers in the 1980s.Thus genetically modified biomaterials with upgraded biological properties, expanding towards mass-scale industrial production, and the considerable consumption in regular universal activities. The techniques used to develop new materials and to modify the properties of existing materials, are subjected to different industries and fields of scientific researches.CRISPR is anauthoritative research tool that facilitates scientists to deal with the expression of a gene. It has shown tremendous potential in genome research due to its ability to delete unwanted traits, and possibly even replace them with desirable traits. It is agile, worthwhile, and more authentic than any preceding gene-editing techniques. Genetically engineered biomaterials have been an enormous field of research over the last fifteen years and CRISPR has already initiated performing a significant aspect in boosting biomaterial research.","PeriodicalId":89733,"journal":{"name":"Advancements in genetic engineering","volume":"9 1","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69998439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.4172/2169-0111.1000158
Xiu Quan Zhang, Yu Ting Zhang, Lin Li, X. Tian, W. Lu, Y. Zhou
Congenital ectrodactyly is usually clinically characterized with phalangeal dysplasia. Severe cases may be manifested with median split of hand and foot and/or combined with fusion of the rest fingers and toes, named a syndrome of split hand/foot malformation (SHFM). Some severe patients may be accompanied by ectodermal and craniofacial dysplasia, mental retardation and orofacial fissure. Till now there were seven types of SHFM reported. Among them, SHFM1, SHFM3, SHFM4, and SHFM5 are autosomal dominant, SHFM6 is autosomal recessive, SHFM2 is X-linked inheritance, and SHFLD manifested as autosomal incomplete dominant inheritance. The related genes are DSSI, DLX5, and DLX6 at 7q21.3-q22.1 (SHFM1), FGF3 and TDU at Xq26 (SHFM2), HUG1、TLX1、LBX1、BTRC、POLL、FBXW4 at 10q24 (SHFM3), TP63 at 3q27 (SHFM4), DLX1, DLX2 at 2q31 (SHFM5), WNT10B at 12q13.11-q13 (SHFM6), and BHLHA9 at 17p13.3 or l19p13.11. Gene diagnosis is the key to locate the mutation and the effective methods for healthy reproduction. Genetic diagnostic steps should be based on genetic frequency and the healthy reproductive strategy may be based on pre-implantation genetic diagnosis (PGD) and prenatal genetic diagnosis.
{"title":"Congenital Ectrodactyly and Its Genetic Linkage","authors":"Xiu Quan Zhang, Yu Ting Zhang, Lin Li, X. Tian, W. Lu, Y. Zhou","doi":"10.4172/2169-0111.1000158","DOIUrl":"https://doi.org/10.4172/2169-0111.1000158","url":null,"abstract":"Congenital ectrodactyly is usually clinically characterized with phalangeal dysplasia. Severe cases may be manifested with median split of hand and foot and/or combined with fusion of the rest fingers and toes, named a syndrome of split hand/foot malformation (SHFM). Some severe patients may be accompanied by ectodermal and craniofacial dysplasia, mental retardation and orofacial fissure. Till now there were seven types of SHFM reported. Among them, SHFM1, SHFM3, SHFM4, and SHFM5 are autosomal dominant, SHFM6 is autosomal recessive, SHFM2 is X-linked inheritance, and SHFLD manifested as autosomal incomplete dominant inheritance. The related genes are DSSI, DLX5, and DLX6 at 7q21.3-q22.1 (SHFM1), FGF3 and TDU at Xq26 (SHFM2), HUG1、TLX1、LBX1、BTRC、POLL、FBXW4 at 10q24 (SHFM3), TP63 at 3q27 (SHFM4), DLX1, DLX2 at 2q31 (SHFM5), WNT10B at 12q13.11-q13 (SHFM6), and BHLHA9 at 17p13.3 or l19p13.11. Gene diagnosis is the key to locate the mutation and the effective methods for healthy reproduction. Genetic diagnostic steps should be based on genetic frequency and the healthy reproductive strategy may be based on pre-implantation genetic diagnosis (PGD) and prenatal genetic diagnosis.","PeriodicalId":89733,"journal":{"name":"Advancements in genetic engineering","volume":"7 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70877119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-05-23DOI: 10.4172/2169-0111.1000157
A. Banerjee, Sreeparna Banerjee, D. Das, B. Maji, S. Mukherjee
Slit-Robo could be a cell signaling pathway with numerous functions such as axon steering and ontogenesis. Slit is a secreted macromolecule and most generally referred to as a repulsive axon steering cue, and Robo as its trans-membrane macromolecular receptor. This ligand-receptor combination has been concerned in different kind of neuronal and non-neuronal processes starting from cell migration to ontogenesis, tumorigenesis and organogenesis like kidneys, lungs and breasts, etc. Roundabout receptors (Robo) and their Slit ligands were detected in axon steering. Slit was primarily associate degree extracellular matrix super molecule and expressed by plane interstitial tissue in fruit fly. Slits acted as chemorepellents for axons crossing the plane in vertebrates and invertebrates. The origin of Robo proteins were from fruit fly in an exceedingly mutant screening for genes concerned with the regulation of plane crossing. This ligandreceptor try has been involved exceedingly in somatic cell and non-neuronal processes starting from cell migration to maturation, tumorigenesis and organogenesis of tissues like kidneys, lungs and breasts, etc. This pathway act as a substance receptor pathway where Slit proteins bind with Robo receptors and convert signals for axon steering through plane commissures. Recent studies have confronted the role of this signal in numerous fields outside ontogeny like maturation and cancer progression. Here the fundamental framework of Slit/Robo structure and its general pathway with special stress on its operation in stomach cancer are summarized.
{"title":"Slit/Robo Pathway - Neurogenesis to Cancer Progression: A Potential Therapeutic Target","authors":"A. Banerjee, Sreeparna Banerjee, D. Das, B. Maji, S. Mukherjee","doi":"10.4172/2169-0111.1000157","DOIUrl":"https://doi.org/10.4172/2169-0111.1000157","url":null,"abstract":"Slit-Robo could be a cell signaling pathway with numerous functions such as axon steering and ontogenesis. Slit is a secreted macromolecule and most generally referred to as a repulsive axon steering cue, and Robo as its trans-membrane macromolecular receptor. This ligand-receptor combination has been concerned in different kind of neuronal and non-neuronal processes starting from cell migration to ontogenesis, tumorigenesis and organogenesis like kidneys, lungs and breasts, etc. \u0000Roundabout receptors (Robo) and their Slit ligands were detected in axon steering. Slit was primarily associate degree extracellular matrix super molecule and expressed by plane interstitial tissue in fruit fly. Slits acted as chemorepellents for axons crossing the plane in vertebrates and invertebrates. The origin of Robo proteins were from fruit fly in an exceedingly mutant screening for genes concerned with the regulation of plane crossing. This ligandreceptor try has been involved exceedingly in somatic cell and non-neuronal processes starting from cell migration to maturation, tumorigenesis and organogenesis of tissues like kidneys, lungs and breasts, etc. This pathway act as a substance receptor pathway where Slit proteins bind with Robo receptors and convert signals for axon steering through plane commissures. Recent studies have confronted the role of this signal in numerous fields outside ontogeny like maturation and cancer progression. Here the fundamental framework of Slit/Robo structure and its general pathway with special stress on its operation in stomach cancer are summarized.","PeriodicalId":89733,"journal":{"name":"Advancements in genetic engineering","volume":"2017 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2017-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41599995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-03-23DOI: 10.4172/2169-0111.1000E116
A. Banerjee
Gene-directed protein prodrug medical aid (GDEPT) may be a promising strategy that aims to limit the general toxicity associate degreed improve the property of therapy use through the expression of a factor that encodes associate degree catalyst that converts nontoxic prodrug into an activated cytotoxic agent. It offers a brand new approach to treating some cancers. Clinical trials are completed for brain and prostate cancers and also the initial product for post-surgical treatment of some brain tumors is awaiting selling approval. Recent innovations offer a glimpse into the doable future evolution of a brand new cistron medication [1].
{"title":"Gene-Directed Enzyme Pro-drug Therapy: A Promising Way for Cancer Treatment","authors":"A. Banerjee","doi":"10.4172/2169-0111.1000E116","DOIUrl":"https://doi.org/10.4172/2169-0111.1000E116","url":null,"abstract":"Gene-directed protein prodrug medical aid (GDEPT) may be a promising strategy that aims to limit the general toxicity associate degreed improve the property of therapy use through the expression of a factor that encodes associate degree catalyst that converts nontoxic prodrug into an activated cytotoxic agent. It offers a brand new approach to treating some cancers. Clinical trials are completed for brain and prostate cancers and also the initial product for post-surgical treatment of some brain tumors is awaiting selling approval. Recent innovations offer a glimpse into the doable future evolution of a brand new cistron medication [1].","PeriodicalId":89733,"journal":{"name":"Advancements in genetic engineering","volume":"6 1","pages":"1-1"},"PeriodicalIF":0.0,"publicationDate":"2017-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2169-0111.1000E116","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44814984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-08-01DOI: 10.4172/2169-0111.1000I106
A. A. Aboulila, A. Ali, M. Mahmoud
Technology of transgenic plants production will have an important and powerful impact on some of the immediate problems of vegetable crops, such as abiotic stresses and phytopathogens attack, and could reduce dependence on chemical pesticides and fungicides.
{"title":"Gus A Gene Expression in Transgenic Tomato Plants Mediated Agrobacteriumtumefaciens","authors":"A. A. Aboulila, A. Ali, M. Mahmoud","doi":"10.4172/2169-0111.1000I106","DOIUrl":"https://doi.org/10.4172/2169-0111.1000I106","url":null,"abstract":"Technology of transgenic plants production will have an important and powerful impact on some of the immediate problems of vegetable crops, such as abiotic stresses and phytopathogens attack, and could reduce dependence on chemical pesticides and fungicides.","PeriodicalId":89733,"journal":{"name":"Advancements in genetic engineering","volume":"5 1","pages":"0-0"},"PeriodicalIF":0.0,"publicationDate":"2016-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2169-0111.1000I106","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70877774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-06-01DOI: 10.4172/2169-0111.1000155
N. Sharma, S. Singh, S. Lal
Gene mining for various biotic and abiotic stresses could be utilized only when we can transfer them to our important crops so that a large number of the population can be benefitted by this. In this light gene transfer through various methods can be done and it will be more useful where traditional breeding approach is not feasible. However, transgenic research in fruit crops is very low so that present information will be utilized by fruit breeders to a design future program for developing transgenic that ultimately open the way for those crops where gene transfer is difficult through conventional breeding.
{"title":"Transgenic Research in Fruit Crops: Current Status","authors":"N. Sharma, S. Singh, S. Lal","doi":"10.4172/2169-0111.1000155","DOIUrl":"https://doi.org/10.4172/2169-0111.1000155","url":null,"abstract":"Gene mining for various biotic and abiotic stresses could be utilized only when we can transfer them to our important crops so that a large number of the population can be benefitted by this. In this light gene transfer through various methods can be done and it will be more useful where traditional breeding approach is not feasible. However, transgenic research in fruit crops is very low so that present information will be utilized by fruit breeders to a design future program for developing transgenic that ultimately open the way for those crops where gene transfer is difficult through conventional breeding.","PeriodicalId":89733,"journal":{"name":"Advancements in genetic engineering","volume":"5 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2016-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2169-0111.1000155","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70877433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-05-02DOI: 10.4172/2169-0111.1000156
Abrar Ahmad, V. Hahn‐Strömberg
Cell-cell adhesion and communication relies greatly on the E-cadherin/catenin system. Deregulation in this system may result in phenotypic change, which may create an opportunity for tumor cells to differentiate, metastasize and invade neighbouring tissue. In this study, we aimed to assess the protein expression of E-cadherin and β-catenin in the patients diagnosed with colon carcinoma correlating the levels with growth pattern of tumors using complexity index analysis as well as clinical and pathological features of the patients. 129 colon carcinoma patients were selected to evaluate the protein expression of E-cadherin and β-catenin through immunohistochemical staining. Complexity index of randomly selected patients diagnosed with colon carcinoma was calculated to examine the growth pattern of the tumor. Expression of adhesion proteins was significantly perturbed in colon carcinoma patients as compared with normal mucosa (p<0.05). Similarly the growth pattern of tumor i.e., complexity index value was significantly related to differentiation of the tumor (p=0.002) and Duke’s stages (p=0.026). Our results suggest that E-cadherin and β-catenin may play an indicative role in colorectal cancer invasion and disease progression which may act as prognostic markers in colorectal carcinoma. Also complexity index and adhesive proteins distribution are two independent markers which should aid the development of novel strategies for prevention as well as individual treatment of colon carcinoma.
{"title":"Expression of β-Catenin and E-Cadherin, their Clinical Significance and Association with Complexity Index of Colon Carcinoma.","authors":"Abrar Ahmad, V. Hahn‐Strömberg","doi":"10.4172/2169-0111.1000156","DOIUrl":"https://doi.org/10.4172/2169-0111.1000156","url":null,"abstract":"Cell-cell adhesion and communication relies greatly on the E-cadherin/catenin system. Deregulation in this system may result in phenotypic change, which may create an opportunity for tumor cells to differentiate, metastasize and invade neighbouring tissue. In this study, we aimed to assess the protein expression of E-cadherin and β-catenin in the patients diagnosed with colon carcinoma correlating the levels with growth pattern of tumors using complexity index analysis as well as clinical and pathological features of the patients. 129 colon carcinoma patients were selected to evaluate the protein expression of E-cadherin and β-catenin through immunohistochemical staining. Complexity index of randomly selected patients diagnosed with colon carcinoma was calculated to examine the growth pattern of the tumor. Expression of adhesion proteins was significantly perturbed in colon carcinoma patients as compared with normal mucosa (p<0.05). Similarly the growth pattern of tumor i.e., complexity index value was significantly related to differentiation of the tumor (p=0.002) and Duke’s stages (p=0.026). Our results suggest that E-cadherin and β-catenin may play an indicative role in colorectal cancer invasion and disease progression which may act as prognostic markers in colorectal carcinoma. Also complexity index and adhesive proteins distribution are two independent markers which should aid the development of novel strategies for prevention as well as individual treatment of colon carcinoma.","PeriodicalId":89733,"journal":{"name":"Advancements in genetic engineering","volume":"5 1","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2016-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2169-0111.1000156","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70877059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-04-27DOI: 10.4172/2169-0111.1000I105
P. Khambhala, S. Verma, S. Joshi, S. Seshadri, V. Kothari
Pathogenic bacteria develop antibiotic-resistance at a pace much faster than the pace at which new antimicrobials can be discovered and introduced into the market. The process of new drug development demands identification of novel targets in the pathogenic population. Conventional antibiotics have largely targeted bacterial cell wall synthesis, protein synthesis, or nucleic acid synthesis. However in recent years, quorum sensing (QS) machinery of the pathogenic bacteria has received considerable attention as potential target of novel anti-infective agents.
{"title":"Inhibition of Bacterial Quorum-Sensing by Ferula asafoetida Essential Oil","authors":"P. Khambhala, S. Verma, S. Joshi, S. Seshadri, V. Kothari","doi":"10.4172/2169-0111.1000I105","DOIUrl":"https://doi.org/10.4172/2169-0111.1000I105","url":null,"abstract":"Pathogenic bacteria develop antibiotic-resistance at a pace much faster than the pace at which new antimicrobials can be discovered and introduced into the market. The process of new drug development demands identification of novel targets in the pathogenic population. Conventional antibiotics have largely targeted bacterial cell wall synthesis, protein synthesis, or nucleic acid synthesis. However in recent years, quorum sensing (QS) machinery of the pathogenic bacteria has received considerable attention as potential target of novel anti-infective agents.","PeriodicalId":89733,"journal":{"name":"Advancements in genetic engineering","volume":"5 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2016-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70877760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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