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Evaluating the Cost-Effectiveness of Antenatal Screening for Major Structural Anomalies During the First Trimester of Pregnancy: A Decision Model 评估主要结构异常产前筛查在妊娠前三个月的成本效益:决策模型
Pub Date : 2025-01-21 DOI: 10.1111/1471-0528.18053
Helen E. Campbell, Jehan N. Karim, Aris T. Papageorghiou, Edward C. F. Wilson, Oliver Rivero-Arias
To assess the cost-effectiveness of modifying current antenatal screening by adding first trimester structural anomaly screening to standard of care second trimester anomaly screening.
通过在标准的妊娠中期异常筛查中增加妊娠早期结构异常筛查,来评估修改现行产前筛查的成本效益。
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引用次数: 0
Joint Effects of Maternal Comorbidity and Neighbourhood Income Mobility on the Ensuing Risk of Severe Maternal Morbidity 孕产妇共病和邻里收入流动对随之而来的严重孕产妇发病风险的共同影响
Pub Date : 2025-01-20 DOI: 10.1111/1471-0528.18078
Jennifer A. Jairam, Eyal Cohen, Christina Diong, Hilary K. Brown, Jun Guan, Howard Berger, Joel G. Ray

Conflicts of Interest

The authors declare no conflicts of interest.

利益冲突作者声明无利益冲突。
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引用次数: 0
INTERGROWTH-21st Birthweight Charts Offer Excellent Concordance With UK-WHO Birthweight Charts Used by Neonatologists intergrowth -21出生体重图与英国-世卫组织新生儿学家使用的出生体重图具有良好的一致性
Pub Date : 2025-01-20 DOI: 10.1111/1471-0528.18048
Relph Sophie Alexandra, Stirnemann Julien Josseph, Napolitano Raffaele
<p>There is a wide range of charts available for the assessment of estimated foetal weight (EFW) and measured neonatal weight centiles at a given gestational age. Charts vary in methodology, with descriptive and prescriptive, population and customised versions available, many designed with a high risk of bias [<span>1, 2</span>]. In many countries, including the UK, operators use varied charts for prenatal and neonatal care, leading to disagreement on diagnosis of abnormal growth. In determining which chart to apply in our tertiary centre and potentially nationwide, we aimed to identify a chart package that is applicable to our population, offers charts for assessment of EFW, actual birthweight and fundal height and is concordant with the UK-WHO birthweight charts recommended nationally by the Royal College of Paediatrics and Child Health (RCPCH—rcpch.ac.uk) which are based on British growth reference centiles derived by Cole in 1990 [<span>3</span>]. Such concordance should facilitate agreement on small or large sizes, including the presence of growth restriction, between obstetricians and neonatologists, improving continuity of care with regard to the risk of perinatal morbidity and mortality. The INTERGROWTH-21st package offers both foetal and neonatal charts and has previously shown good continuity of growth between prenatal and neonatal centiles at late pre-term and term gestations in these populations when EFW in grams was calculated using both their formula including head and abdominal circumference only, or the Hadlock's formula, using three parameters (head, abdominal circumference and femur length) [<span>4, 5</span>]. INTERGROWTH-21st prenatal chart centiles have also been shown to adequately fit the distribution of a large French prospective sample of ultrasound-derived foetal measurements [<span>6</span>]. Here, we describe work to evaluate whether the INTERGROWTH-21st birthweight centiles are concordant with those of the UK-WHO birthweight charts for pre-term and term births [<span>7</span>].</p><p>We used 10th, 50th and 90th centile thresholds published by the INTERGROWTH-21st group for neonatal birthweight charts at each gestational day between 24 and 42 weeks to produce centile charts for male and female babies. UK-WHO birthweight centiles have only been published in chart format, from which it is difficult to derive the exact birthweight for the 10th, 50th and 90th centiles during each gestational day. We therefore produced a simulation data set, including male and female neonates with birthweights of 10-g increments between 400 and 5500 g, for each gestational day between 24 and 42 weeks. We calculated the UK-WHO birthweight centiles using the Stata ‘zanthro’ command (StataCorp LLC, Texas, USA). <i>Zanthro</i> is a user-written command that calculates z-scores for anthropometric measures according to reference growth charts, with a specific option to apply the Cole UK-WHO charts. We then converted z-scores into birthweight cen
有各种各样的图表可用于评估估计的胎儿体重(EFW)和在给定胎龄测量的新生儿体重百分位数。图表的方法各不相同,有描述性和规范性版本,有总体版本和定制版本,许多设计具有高偏倚风险[1,2]。在包括英国在内的许多国家,操作员使用不同的图表进行产前和新生儿护理,导致对异常生长的诊断存在分歧。在确定在我们的三级中心和潜在的全国范围内应用哪个图表时,我们的目标是确定一个适用于我们人口的图表包,提供EFW,实际出生体重和基础身高评估图表,并与皇家儿科和儿童健康学院(RCPCH-rcpch.ac.uk)在全国范围内推荐的英国-世卫组织出生体重图表一致,该图表基于英国生长参考百分位数,由Cole在1990年得出。这种一致性应促进产科医生和新生儿科医生就小尺寸或大尺寸(包括是否存在生长限制)达成一致,从而提高围产期发病率和死亡率风险方面护理的连续性。intergrowth -21包提供了胎儿和新生儿图表,并且在这些人群中,当使用仅包括头和腹围的公式或使用三个参数(头、腹围和股骨长度)的Hadlock公式计算以克为单位的EFW时,先前显示出产前和早产儿晚期和足月妊娠期间新生儿centiles之间生长的良好连续性[4,5]。intergrowth -21产前图百分位也被证明充分符合法国超声衍生胎儿测量的大型前瞻性样本的分布[6]。在这里,我们描述了评估intergrowth -21出生体重百分位数与英国-世界卫生组织早产儿和足月新生儿出生体重图表是否一致的工作。我们使用intergrowth -21组公布的第10、50和90百分位阈值,在24至42周的每个妊娠日制作男婴和女婴的百分位图。英国-世卫组织出生体重百分位数仅以图表格式公布,从中很难得出每个妊娠日第10、50和90百分位数的确切出生体重。因此,我们制作了一个模拟数据集,包括出生体重在400至5500克之间增加10克的男性和女性新生儿,每个妊娠日在24至42周之间。我们使用Stata ‘ zanthro ’命令(StataCorp LLC, Texas, USA)计算了英国-世卫组织出生体重百分位数。Zanthro是一个用户编写的命令,可以根据参考生长图表计算人体测量的z分数,并具有应用Cole UK-WHO图表的特定选项。然后,我们将z分数转换为出生体重百分位数,以确定每个胎龄的第10、50和90百分位数的出生体重。我们将所有intergrowth -21和UK-WHO的出生体重百分位数绘制在同一个图表上,但分别针对男性和女性婴儿。在图1中,我们显示了男女婴儿的intergrowth -21出生体重图与英国新生儿学家使用的英国-世卫组织人口参考图在38周之前具有良好的一致性,并且在每个百分位的出生体重和总体轨迹方面具有令人满意的一致性。对于38周出生的雄性,图表之间的差异是第10百分位10g,第50百分位60g,第90百分位80g(雌性分别为20g, 30g和50g)。到42周时,这一差异在第10百分位增加到210克,在第50百分位增加到370克,在第90百分位增加到510克(雌性分别为200、330和430克)。对于给定的出生体重和胎龄,每个图表得出的百分位数的差异如图1所示。图1打开图形查看器(powerpoint),比较intergrowth -21和Cole等人的出生体重大小图表。英国世卫组织出生体重百分位数。该研究的局限性在于使用模拟数据集来计算每个百分位阈值的胎龄特异性出生体重;然而,由于原始公式尚未被Cole等人发表,这是探索图表差异最合适的方法。我们的结论是,intergrowth -21出生体重图满足我们在英国产科单位和全国范围内实施的标准。intergrowth -21提供了一套完整的胎儿和新生儿体重评估图表,以及基础身高图表(英国-世卫组织提供的图表中并非所有选项都可用),与英国-世卫组织出生体重图表的一致性令人满意,RCPCH在全国范围内推荐,特别是针对胎龄较小的婴儿。 孕38周以上的第50百分位和第90百分位的差异更大,intergrowth -21出生体重将更大比例的婴儿归类为大胎龄婴儿。
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引用次数: 0
Salpingectomy With Delayed Oophorectomy Versus Salpingo‐Oophorectomy in BRCA1/2 Carriers: Three‐Year Outcomes of a Prospective Preference Trial BRCA1/2携带者输卵管切除术加延迟卵巢切除术与输卵管-卵巢切除术:一项前瞻性偏好试验的三年结果
Pub Date : 2025-01-17 DOI: 10.1111/1471-0528.18075
Majke H. D. Van Bommel, Miranda P. Steenbeek, Joanna Inthout, Tessa Van Garderen, Marline G. Harmsen, Marieke Arts‐De Jong, Angela H. E. M. Maas, Judith B. Prins, Johan Bulten, Helena C. Van Doorn, Marian J. E. Mourits, Rachel Tros, Ronald P. Zweemer, Katja N. Gaarenstroom, Brigitte F. M. Slangen, Monique M. A. Brood‐Van Zanten, M. Caroline Vos, Jurgen M. J. Piek, Luc R. C. W. van Lonkhuijzen, Mirjam J. A. Apperloo, Sjors F. P. J. Coppus, Nicoline Hoogerbrugge, Rosella P. M. G. Hermens, Joanne A. De Hullu
ObjectiveTo compare menopause‐related quality of life (QoL) after risk‐reducing salpingectomy (RRS) versus risk‐reducing salpingo‐oophorectomy (RRSO) until 3 years of post‐surgery.DesignA prospective study (TUBA study) with treatment allocation based on patients' preference. Data were collected pre‐surgery and at 3 months, 1 and 3 years of post‐surgery.SettingMulticentre prospective preference trial in thirteen hospitals in the Netherlands.PopulationBRCA1/2 pathogenic variant (PV) carriers aged 25–40 (BRCA1) or 25–45 (BRCA2), who were premenopausal, without a future child wish and without current (treatment for) malignancy.MethodsTreatment allocation was based on patients' preference: either RRS from the age of 25 years with delayed oophorectomy at the maximum age of 45 (BRCA1) or 50 (BRCA2), or RRSO between the ages of 35–40 (BRCA1) or 40–45 (BRCA2). After RRSO, hormone replacement therapy (HRT) was recommended, if not contraindicated. Primarily, menopause‐related QoL as measured with the Greene Climacteric Scale (GCS) was compared between the RRS and RRSO without HRT group. Secondarily, GSC‐scores of the RRS group were compared with the scores of the RRSO with HRT after surgery group. A higher GSC‐score reflects more climacteric symptoms.ResultsUntil April 2023, 410 participants had undergone RRS and 160 RRSO. The BRCA1/BRCA2 proportions were 51.4%/48.6%. The mean age at surgery (SD) was 37.9 (3.5) years. Participants 3 years after RRSO without HRT had a 4.3 (95% CI 2.1–6.5; p < 0.001) point higher increase in GCS‐score from baseline compared to those after RRS, while the difference was 7.9 (95% CI 5.9–9.8) and 8.5 (95% CI 6.5–10.5) points at 3 and 12 months, respectively. Among participants with HRT after surgery, the RRSO group had a 2.4 (95% CI 0.8–3.9; p = 0.002) point higher increase in GCS‐score from baseline compared to the RRS group.ConclusionsIn this multicentre preference trial, menopause‐related QoL was better after RRS than after RRSO, even with HRT after RRSO. Differences between arms were most pronounced until one‐year post‐surgery.
目的比较降低风险的输卵管切除术(RRS)与降低风险的输卵管切除术(RRSO)术后至术后 3 年与绝经相关的生活质量(QoL)。人群BRCA1/2致病性变异(PV)携带者,年龄在25-40岁(BRCA1)或25-45岁(BRCA2),绝经前,无生育意愿,目前无恶性肿瘤(治疗)。方法根据患者的意愿进行治疗分配:或者从 25 岁开始进行 RRS,并在最高 45 岁(BRCA1)或 50 岁(BRCA2)时延迟进行输卵管切除术;或者在 35-40 岁(BRCA1)或 40-45 岁(BRCA2)之间进行 RRSO。RRSO 后,如果没有禁忌症,建议采用激素替代疗法(HRT)。首先,比较了 RRSO 组和不使用 HRT 的 RRSO 组使用格林 Climacteric Scale(GCS)测量的更年期相关 QoL。其次,将 RRS 组的 GSC 分数与术后接受 HRT 的 RRSO 组的分数进行比较。结果截至2023年4月,410名参与者接受了RRS手术,160名参与者接受了RRSO手术。BRCA1/BRCA2比例为51.4%/48.6%。手术时的平均年龄(标清)为 37.9 (3.5) 岁。RRSO 术后 3 年未接受 HRT 的患者与 RRS 术后的患者相比,GCS 评分比基线高出 4.3 (95% CI 2.1-6.5; p < 0.001)分,而 3 个月和 12 个月时的差异分别为 7.9 (95% CI 5.9-9.8) 分和 8.5 (95% CI 6.5-10.5) 分。结论在这项多中心优选试验中,RRS术后的更年期相关生活质量优于RRSO术后,即使在RRSO术后进行HRT治疗。两组间的差异在术后一年前最为明显。
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引用次数: 0
Intrauterine Contraction Monitoring in Chorioamnionitis: A Secondary, Blinded Analysis of a Randomised Controlled Trial Cohort 绒毛膜羊膜炎的宫内收缩监测:一项随机对照试验队列的二次盲法分析
Pub Date : 2025-01-16 DOI: 10.1111/1471-0528.18076
Milla Juhantalo, Tuija Hautakangas, Outi Palomäki, Jukka Uotila
To study the effects of chorioamnionitis on uterine activity and to investigate associations between external and intrauterine monitoring methods and neonatal outcomes.
目的:研究绒毛膜羊膜炎对子宫活动的影响,探讨体外和宫内监测方法与新生儿结局的关系。
{"title":"Intrauterine Contraction Monitoring in Chorioamnionitis: A Secondary, Blinded Analysis of a Randomised Controlled Trial Cohort","authors":"Milla Juhantalo, Tuija Hautakangas, Outi Palomäki, Jukka Uotila","doi":"10.1111/1471-0528.18076","DOIUrl":"https://doi.org/10.1111/1471-0528.18076","url":null,"abstract":"To study the effects of chorioamnionitis on uterine activity and to investigate associations between external and intrauterine monitoring methods and neonatal outcomes.","PeriodicalId":8984,"journal":{"name":"BJOG: An International Journal of Obstetrics & Gynaecology","volume":"80 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142987148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Predicting Preterm Birth: An Evolving Landscape 预测早产:不断演变的格局
Pub Date : 2025-01-14 DOI: 10.1111/1471-0528.18067
Caroline Fox, Andrew Shennan
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引用次数: 0
Refining Global Analysis of Female Breast and Gynaecologic Cancers: Suggestions for Enhanced Methodology and Data Update 完善女性乳腺癌和妇科癌症的全球分析:改进方法和数据更新的建议
Pub Date : 2025-01-13 DOI: 10.1111/1471-0528.18071
Haojie Cai, Shanshan Cheng, Yu Wang
Click on the article title to read more.
点击文章标题阅读更多内容。
{"title":"Refining Global Analysis of Female Breast and Gynaecologic Cancers: Suggestions for Enhanced Methodology and Data Update","authors":"Haojie Cai, Shanshan Cheng, Yu Wang","doi":"10.1111/1471-0528.18071","DOIUrl":"https://doi.org/10.1111/1471-0528.18071","url":null,"abstract":"Click on the article title to read more.","PeriodicalId":8984,"journal":{"name":"BJOG: An International Journal of Obstetrics & Gynaecology","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142967908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Consensus on Symptom Selection for Endometriosis Questionnaires: A Modified e-Delphi Study 子宫内膜异位症症状选择的共识:一项修正的e-Delphi研究
Pub Date : 2025-01-13 DOI: 10.1111/1471-0528.18066
Tong Zhu, Henrik Marschall, Karina E. Hansen, Andrew W. Horne, Lucky Saraswat, Krina T. Zondervan, Stacey A. Missmer, Lone Hummelshoj, Atilla Bokor, Camilla S. Østrup, Anna Melgaard, Dorte Rytter
To build consensus on most important symptoms and related consequences for use in questionnaires to characterise individuals with suspected and confirmed endometriosis in the general population.
就最重要的症状和相关后果建立共识,用于问卷调查,以确定一般人群中疑似和确诊子宫内膜异位症的个体特征。
{"title":"Consensus on Symptom Selection for Endometriosis Questionnaires: A Modified e-Delphi Study","authors":"Tong Zhu, Henrik Marschall, Karina E. Hansen, Andrew W. Horne, Lucky Saraswat, Krina T. Zondervan, Stacey A. Missmer, Lone Hummelshoj, Atilla Bokor, Camilla S. Østrup, Anna Melgaard, Dorte Rytter","doi":"10.1111/1471-0528.18066","DOIUrl":"https://doi.org/10.1111/1471-0528.18066","url":null,"abstract":"To build consensus on most important symptoms and related consequences for use in questionnaires to characterise individuals with suspected and confirmed endometriosis in the general population.","PeriodicalId":8984,"journal":{"name":"BJOG: An International Journal of Obstetrics & Gynaecology","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142967909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
L-Arginine and L-Citrulline for Prevention and Treatment of Pre-Eclampsia: A Systematic Review and Meta-Analysis l -精氨酸和l -瓜氨酸预防和治疗子痫前期:一项系统综述和荟萃分析
Pub Date : 2025-01-12 DOI: 10.1111/1471-0528.18070
Maureen Makama, Annie R. A. McDougall, Jenny Cao, Kate Mills, Phi-Yen Nguyen, Roxanne Hastie, Anne Ammerdorffer, A. Metin Gülmezoglu, Joshua P. Vogel
Evidence suggests L-arginine may be effective at reducing pre-eclampsia and related outcomes. However, whether L-arginine can prevent or only treat pre-eclampsia, and thus the target population and timing of initiation, remains unknown.
有证据表明l -精氨酸可能对减少先兆子痫和相关结果有效。然而,l -精氨酸是否可以预防或仅治疗先兆子痫,因此目标人群和起始时间仍然未知。
{"title":"L-Arginine and L-Citrulline for Prevention and Treatment of Pre-Eclampsia: A Systematic Review and Meta-Analysis","authors":"Maureen Makama, Annie R. A. McDougall, Jenny Cao, Kate Mills, Phi-Yen Nguyen, Roxanne Hastie, Anne Ammerdorffer, A. Metin Gülmezoglu, Joshua P. Vogel","doi":"10.1111/1471-0528.18070","DOIUrl":"https://doi.org/10.1111/1471-0528.18070","url":null,"abstract":"Evidence suggests L-arginine may be effective at reducing pre-eclampsia and related outcomes. However, whether L-arginine can prevent or only treat pre-eclampsia, and thus the target population and timing of initiation, remains unknown.","PeriodicalId":8984,"journal":{"name":"BJOG: An International Journal of Obstetrics & Gynaecology","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142967907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prolonged Ovarian Stimulation Does Not Worsen Neonatal Outcomes After Fresh Embryo Transfers 延长卵巢刺激不会使新鲜胚胎移植后新生儿结局恶化
Pub Date : 2025-01-10 DOI: 10.1111/1471-0528.18062
Jing Wu, Ying Ju, Jie Dong, Hengde Zhang, Xifeng Xiao, Xiaohong Wang
To investigate the relationship between prolonged ovarian stimulation and neonatal outcomes after autologous fresh embryo transfer (fET).
探讨自体新鲜胚胎移植(fET)后卵巢刺激时间延长与新生儿结局的关系。
{"title":"Prolonged Ovarian Stimulation Does Not Worsen Neonatal Outcomes After Fresh Embryo Transfers","authors":"Jing Wu, Ying Ju, Jie Dong, Hengde Zhang, Xifeng Xiao, Xiaohong Wang","doi":"10.1111/1471-0528.18062","DOIUrl":"https://doi.org/10.1111/1471-0528.18062","url":null,"abstract":"To investigate the relationship between prolonged ovarian stimulation and neonatal outcomes after autologous fresh embryo transfer (fET).","PeriodicalId":8984,"journal":{"name":"BJOG: An International Journal of Obstetrics & Gynaecology","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142940075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
BJOG: An International Journal of Obstetrics & Gynaecology
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