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Pheromonal effects on germ cells of house mouse males: possible evolutionary consequences 信息素对雄性家鼠生殖细胞的影响:可能的进化后果
Q3 Agricultural and Biological Sciences Pub Date : 2019-01-01 DOI: 10.21638/spbu03.2019.207
E. Daev
It is well known that in mice some pheromones modify reproductively important features. But the genetic mechanisms underlying such changes remain insuffi ciently studied. Here we show that in laboratory mice ( Mus musculus L.), volatile signal 2,5-dimethylpyrazine excreted by donor stressed females increases the level of structural chromosome aberrations and other meiotic disturbances in spermatocytes of recipient males after nasal contact with the volatiles via sniff ing. These chemosignals (i.e. pheromones) also induce abnormalities of sperm heads in the recipient mice. We assume that visible macro-damages at the chromosome level in meiotic cells are marks of a more widely disturbing effect (not only macro- but also micro-damages) of some olfactory signals in meiotic cells. It is most probable that the effects of volatile cues are mediated by the nervous system of the recipient organism. While gross chromosomal aberrations lead mainly to death of damaged cells, some of them (micro-damages of the chromosomes) might reach spermatozoa, and we detected part of them as anomalous sperm heads. Such abnormalities can reduce the fertilizing capac-ity of sperm. Moreover, some of the mutations induced by density-dependent volatile chemosignals can reach the progeny and influence the quantity and ge netic quality of future generations. Possible microevolutionary consequences are discussed.
众所周知,在小鼠中,一些信息素改变了生殖的重要特征。但这种变化背后的遗传机制仍未得到充分研究。在实验小鼠(Mus musus L.)中,供体应激的雌性小鼠分泌的挥发性信号2,5-二甲基吡嗪增加了受体雄性小鼠在通过嗅觉接触挥发物后精母细胞中结构染色体畸变和其他减数分裂紊乱的水平。这些化学信号(即信息素)也会引起受体小鼠精子头部的异常。我们认为,减数分裂细胞在染色体水平上可见的宏观损伤是减数分裂细胞中某些嗅觉信号更广泛干扰效应(不仅是宏观损伤,还有微观损伤)的标志。这是最有可能的,挥发性线索的影响是由受体生物体的神经系统介导的。虽然严重染色体畸变主要导致受损细胞的死亡,但其中一些(染色体的微损伤)可能到达精子,我们检测到其中一部分为异常精子头。这种异常会降低精子的受精能力。此外,由密度依赖的挥发性化学信号引起的一些突变可以到达后代,并影响后代的数量和遗传质量。讨论了可能的微观进化结果。
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Biological Communications
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