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The anticancer properties of the nanocomposite of low-nanoscale Ag nanoparticles obtained in SiO2-grafted polyacrylamide carrier. 在二氧化硅接枝聚丙烯酰胺载体上制备的低纳米银纳米复合材料的抗癌性能。
IF 2.7 3区 医学 Q2 PHARMACOLOGY & PHARMACY
BMC Pharmacology & Toxicology
Pub Date : 2026-03-03 DOI: 10.1186/s40360-026-01115-1
Olga V Akopova, Tatyana Zheltonozhskaya, Svitlana Zahorodnia, Dmytro Klymchuk, Yulia Korkach, Mykola Zavgorodniy, Valery Klepko
{"title":"The anticancer properties of the nanocomposite of low-nanoscale Ag nanoparticles obtained in SiO<sub>2</sub>-grafted polyacrylamide carrier.","authors":"Olga V Akopova, Tatyana Zheltonozhskaya, Svitlana Zahorodnia, Dmytro Klymchuk, Yulia Korkach, Mykola Zavgorodniy, Valery Klepko","doi":"10.1186/s40360-026-01115-1","DOIUrl":"https://doi.org/10.1186/s40360-026-01115-1","url":null,"abstract":"","PeriodicalId":9023,"journal":{"name":"BMC Pharmacology & Toxicology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147347252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development and validation of a population pharmacokinetic model for lacosamide in adult patients with epilepsy to inform precision dosing. 拉科沙胺在成人癫痫患者中的群体药代动力学模型的开发和验证，为精确给药提供信息。
IF 2.7 3区 医学 Q2 PHARMACOLOGY & PHARMACY
BMC Pharmacology & Toxicology
Pub Date : 2026-03-03 DOI: 10.1186/s40360-026-01114-2
Lingyan Yu, Fengqian Mao, Shunan Chen, Kangzhen Yu, Yani Hu, Jie Chen, Wei Hu, Zhenwei Yu, Haibin Dai
{"title":"Development and validation of a population pharmacokinetic model for lacosamide in adult patients with epilepsy to inform precision dosing.","authors":"Lingyan Yu, Fengqian Mao, Shunan Chen, Kangzhen Yu, Yani Hu, Jie Chen, Wei Hu, Zhenwei Yu, Haibin Dai","doi":"10.1186/s40360-026-01114-2","DOIUrl":"https://doi.org/10.1186/s40360-026-01114-2","url":null,"abstract":"","PeriodicalId":9023,"journal":{"name":"BMC Pharmacology & Toxicology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147347240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction: Integrated network toxicology, machine learning and molecular docking reveal the mechanism of benzopyrene-induced periodontitis. 校正：综合网络毒理学、机器学习和分子对接揭示苯并芘诱发牙周炎的机制。
IF 2.7 3区 医学 Q2 PHARMACOLOGY & PHARMACY
BMC Pharmacology & Toxicology
Pub Date : 2026-03-03 DOI: 10.1186/s40360-026-01100-8
Wenjie Wen, Rui Li, Pengpeng Zhuo, Chao Deng, Donglin Zhang
{"title":"Correction: Integrated network toxicology, machine learning and molecular docking reveal the mechanism of benzopyrene-induced periodontitis.","authors":"Wenjie Wen, Rui Li, Pengpeng Zhuo, Chao Deng, Donglin Zhang","doi":"10.1186/s40360-026-01100-8","DOIUrl":"10.1186/s40360-026-01100-8","url":null,"abstract":"","PeriodicalId":9023,"journal":{"name":"BMC Pharmacology & Toxicology","volume":"27 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12958609/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147347303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Crossing ocular barriers with quercetin-SPIONs: modulation of Bax/Bcl-2 balance in normal rat eyes. 槲皮素- spions穿越眼屏障：正常大鼠眼Bax/Bcl-2平衡的调节。
IF 2.7 3区 医学 Q2 PHARMACOLOGY & PHARMACY
BMC Pharmacology & Toxicology
Pub Date : 2026-03-02 DOI: 10.1186/s40360-026-01113-3
Mahtab Hajiaghajanian, Nazanin Movahedi, Dorsa Pouriaii, Zahra Souri, Azam Rezayat, Abolghasem Esmaeili
{"title":"Crossing ocular barriers with quercetin-SPIONs: modulation of Bax/Bcl-2 balance in normal rat eyes.","authors":"Mahtab Hajiaghajanian, Nazanin Movahedi, Dorsa Pouriaii, Zahra Souri, Azam Rezayat, Abolghasem Esmaeili","doi":"10.1186/s40360-026-01113-3","DOIUrl":"https://doi.org/10.1186/s40360-026-01113-3","url":null,"abstract":"","PeriodicalId":9023,"journal":{"name":"BMC Pharmacology & Toxicology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147343513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical pharmacist-led prevention of intravenous drug incompatibilities in an adult ICU: a prospective observational study. 成人ICU中临床药师主导的静脉药物不相容预防：一项前瞻性观察研究。
IF 2.7 3区 医学 Q2 PHARMACOLOGY & PHARMACY
BMC Pharmacology & Toxicology
Pub Date : 2026-02-26 DOI: 10.1186/s40360-026-01095-2
Tülay Kayra, Leyla Ferliçolak, İlker Ateş, Neriman Defne Altıntaş, Arzu Onay-Besikci
{"title":"Clinical pharmacist-led prevention of intravenous drug incompatibilities in an adult ICU: a prospective observational study.","authors":"Tülay Kayra, Leyla Ferliçolak, İlker Ateş, Neriman Defne Altıntaş, Arzu Onay-Besikci","doi":"10.1186/s40360-026-01095-2","DOIUrl":"https://doi.org/10.1186/s40360-026-01095-2","url":null,"abstract":"","PeriodicalId":9023,"journal":{"name":"BMC Pharmacology & Toxicology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147302229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adverse events associated with tirzepatide: a focus on subgroup-specific differences. 与替西肽相关的不良事件：对亚组特异性差异的关注。
IF 2.7 3区 医学 Q2 PHARMACOLOGY & PHARMACY
BMC Pharmacology & Toxicology
Pub Date : 2026-02-26 DOI: 10.1186/s40360-026-01105-3
Zhongming Yu, Yiming Qi, Qian Gan, Guodong Wu, Xinhao Zhang, Cheng Jiang, Jing Li
{"title":"Adverse events associated with tirzepatide: a focus on subgroup-specific differences.","authors":"Zhongming Yu, Yiming Qi, Qian Gan, Guodong Wu, Xinhao Zhang, Cheng Jiang, Jing Li","doi":"10.1186/s40360-026-01105-3","DOIUrl":"https://doi.org/10.1186/s40360-026-01105-3","url":null,"abstract":"","PeriodicalId":9023,"journal":{"name":"BMC Pharmacology & Toxicology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147302199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Penetration and disruption of Salmonella typhimurium biofilm using synthesized citric acid doped zein nanocomposites. 柠檬酸掺杂玉米蛋白纳米复合材料对鼠伤寒沙门菌生物膜的渗透和破坏。
IF 2.7 3区 医学 Q2 PHARMACOLOGY & PHARMACY
BMC Pharmacology & Toxicology
Pub Date : 2026-02-26 DOI: 10.1186/s40360-026-01107-1
Venkteshwar Yadav, Dharm Pal, Anil Kumar Poonia
{"title":"Penetration and disruption of Salmonella typhimurium biofilm using synthesized citric acid doped zein nanocomposites.","authors":"Venkteshwar Yadav, Dharm Pal, Anil Kumar Poonia","doi":"10.1186/s40360-026-01107-1","DOIUrl":"https://doi.org/10.1186/s40360-026-01107-1","url":null,"abstract":"","PeriodicalId":9023,"journal":{"name":"BMC Pharmacology & Toxicology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147302226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of CYP1A2 genetic polymorphisms on the pharmacokinetics of pentoxifylline and its active metabolites. CYP1A2基因多态性对己酮茶碱及其活性代谢物药代动力学的影响。
IF 2.7 3区 医学 Q2 PHARMACOLOGY & PHARMACY
BMC Pharmacology & Toxicology
Pub Date : 2026-02-26 DOI: 10.1186/s40360-026-01106-2
Lingfang Guo, Xue Sun, Bo Qiu, Wanjun Bai, Yabin Du, Haojing Song
{"title":"Effects of CYP1A2 genetic polymorphisms on the pharmacokinetics of pentoxifylline and its active metabolites.","authors":"Lingfang Guo, Xue Sun, Bo Qiu, Wanjun Bai, Yabin Du, Haojing Song","doi":"10.1186/s40360-026-01106-2","DOIUrl":"https://doi.org/10.1186/s40360-026-01106-2","url":null,"abstract":"","PeriodicalId":9023,"journal":{"name":"BMC Pharmacology & Toxicology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147302272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Investigating the mechanisms by which bisphenol A affects osteoarthritis through a novel network toxicology framework and experimental validation. 通过新的网络毒理学框架和实验验证研究双酚A影响骨关节炎的机制。
IF 2.7 3区 医学 Q2 PHARMACOLOGY & PHARMACY
BMC Pharmacology & Toxicology
Pub Date : 2026-02-25 DOI: 10.1186/s40360-026-01108-0
Qiwang He, Shanlang Li, Yining Chen, Yue Liu, Yang Li, Shuqi Min, Shenlong Yi, Feng Li, Xiaohong Zhou
{"title":"Investigating the mechanisms by which bisphenol A affects osteoarthritis through a novel network toxicology framework and experimental validation.","authors":"Qiwang He, Shanlang Li, Yining Chen, Yue Liu, Yang Li, Shuqi Min, Shenlong Yi, Feng Li, Xiaohong Zhou","doi":"10.1186/s40360-026-01108-0","DOIUrl":"https://doi.org/10.1186/s40360-026-01108-0","url":null,"abstract":"","PeriodicalId":9023,"journal":{"name":"BMC Pharmacology & Toxicology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147302181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Empagliflozin and platelet-rich plasma improve stanozolol induced cardiotoxicity by reducing NF-κB/P65, IL-1B and apoptosis. 恩格列净和富血小板血浆通过降低NF-κB/P65、IL-1B和细胞凋亡来改善斯坦诺唑尔诱导的心脏毒性。
IF 2.7 3区 医学 Q2 PHARMACOLOGY & PHARMACY
BMC Pharmacology & Toxicology
Pub Date : 2026-02-23 DOI: 10.1186/s40360-026-01086-3
Shaimaa M Hafez, Eman Mohammed Elsaeed, Amal Hussain Mohammed Ali, Eman S Said, Yara S Abouelela, Asmaa Abdo Elshiech, Heba Abdelnaser Aboelsoud, Hala Magdy Anwer, Samar H Elsharkawy, Marwa A Ibrahim, Hamdy Rizk, Hoda A Abd-Ellatieff
{"title":"Empagliflozin and platelet-rich plasma improve stanozolol induced cardiotoxicity by reducing NF-κB/P65, IL-1B and apoptosis.","authors":"Shaimaa M Hafez, Eman Mohammed Elsaeed, Amal Hussain Mohammed Ali, Eman S Said, Yara S Abouelela, Asmaa Abdo Elshiech, Heba Abdelnaser Aboelsoud, Hala Magdy Anwer, Samar H Elsharkawy, Marwa A Ibrahim, Hamdy Rizk, Hoda A Abd-Ellatieff","doi":"10.1186/s40360-026-01086-3","DOIUrl":"10.1186/s40360-026-01086-3","url":null,"abstract":"","PeriodicalId":9023,"journal":{"name":"BMC Pharmacology & Toxicology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12990588/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147275533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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