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Mapping the scientific literature on obstetric and perinatal health among sexual and gender minoritized (SGM) childbearing people and their infants: a scoping review. 性与性别少数群体(SGM)育龄者及其婴儿的产科和围产期健康科学文献图谱:范围界定审查。
IF 2.8 2区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2024-10-12 DOI: 10.1186/s12884-024-06813-4
Aimee K Huang, Alison R Schulte, Mary-Frances E Hall, Laura Y Chen, Sanjana Srinivasan, Carol Mita, Aava B Jahan, Kodiak R S Soled, Brittany M Charlton

Background: Evidence suggests sexual and gender minoritized (SGM) childbearing individuals and their infants experience more adverse obstetric and perinatal outcomes compared to their cisgender, heterosexual counterparts. This study aimed to comprehensively map obstetric and perinatal physical health literature among SGM populations and their infants and identify knowledge gaps.

Methods: PubMed, Embase, CINAHL, and Web of Science Core Collection were systematically searched to identify published studies reporting obstetric and perinatal outcomes in SGM individuals or their infants. Study characteristics, sample characteristics, and outcome findings were systematically extracted and analyzed.

Results: Our search yielded 8,740 records; 55 studies (1981-2023) were included. Sexual orientation was measured by self-identification (72%), behavior (55%), and attraction (9%). Only one study captured all three dimensions. Inconsistent measures of sexual orientation and gender identity (SOGI) were common, and 68% conflated sex and gender. Most (85%) focused on sexual minorities, while 31% addressed gender minorities. Demographic measures employed varied widely and were inconsistent; 35% lacked race/ethnicity data, and 44% lacked socioeconomic data. Most studies (78%) examined outcomes among SGM individuals, primarily focusing on morbidity and pregnancy outcomes. Pregnancy termination was most frequently studied, while pregnancy and childbirth complications (e.g., gestational hypertension, postpartum hemorrhage) were rarely examined. Evidence of disparities were mixed. Infant outcomes were investigated in 60% of the studies, focusing on preterm birth and low birthweight. Disparities were noted among different sexual orientation and racial/ethnic groups. Qualitative insights highlighted how stigma and discriminatory care settings can lead to adverse pregnancy and birth outcomes.

Conclusions: Frequent conflation of sex and gender and a lack of standardized SOGI measures hinder the comparison and synthesis of existing evidence. Nuanced sociodemographic data should be collected to understand the implications of intersecting identities. Findings on perinatal health disparities were mixed, highlighting the need for standardized SOGI measures and comprehensive sociodemographic data. The impact of stigma and discriminatory care on adverse outcomes underscores the need for inclusive healthcare environments. Future research should address these gaps; research on SGM perinatal outcomes remains urgently lacking.

Trial registration: The review protocol was developed a priori in February 2023, registered on Open Science Framework ( https://doi.org/10.17605/OSF.IO/5DQV4 ) and published in BMJ Open ( https://bmjopen.bmj.com/content/13/11/e075443 ).

背景:有证据表明,与同性异性相比,性行为和性别上属于少数群体(SGM)的育龄个体及其婴儿会经历更多不利的产科和围产期结果。本研究旨在全面了解 SGM 群体及其婴儿的产科和围产期身体健康文献,并找出知识差距:对 PubMed、Embase、CINAHL 和 Web of Science Core Collection 进行了系统检索,以确定报道 SGM 患者或其婴儿产科和围产期结果的已发表研究。系统地提取并分析了研究特征、样本特征和结果:我们的搜索共获得 8740 条记录,其中包括 55 项研究(1981-2023 年)。性取向通过自我认同(72%)、行为(55%)和吸引力(9%)来衡量。只有一项研究涵盖了所有三个方面。对性取向和性别认同(SOGI)的测量不一致的情况很普遍,68%的研究将性和性别混为一谈。大多数研究(85%)关注的是性取向少数群体,而 31% 的研究关注的是性别少数群体。采用的人口统计学测量方法差异很大,而且不一致;35% 的研究缺乏种族/族裔数据,44% 的研究缺乏社会经济数据。大多数研究(78%)对 SGM 患者的结果进行了调查,主要集中在发病率和妊娠结果上。对终止妊娠的研究最多,而对妊娠和分娩并发症(如妊娠高血压、产后出血)的研究则很少。有关差异的证据参差不齐。60% 的研究对婴儿的结局进行了调查,重点是早产和出生体重不足。不同性取向和种族/民族群体之间存在差异。定性分析强调了污名化和歧视性护理环境如何导致不良的妊娠和分娩结果:结论:性和性别经常被混淆,而且缺乏标准化的社会性别平等衡量标准,这些都阻碍了对现有证据的比较和综合。应收集细致入微的社会人口数据,以了解交叉身份的影响。关于围产期健康差异的研究结果喜忧参半,这凸显了标准化的社会性别平等测量方法和全面的社会人口数据的必要性。污名化和歧视性护理对不良后果的影响强调了包容性医疗环境的必要性。未来的研究应弥补这些不足;有关SGM围产期结局的研究仍然十分缺乏:该综述方案于 2023 年 2 月事先制定,在开放科学框架 ( https://doi.org/10.17605/OSF.IO/5DQV4 ) 上注册,并在 BMJ Open ( https://bmjopen.bmj.com/content/13/11/e075443 ) 上发表。
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引用次数: 0
Childbirth self-efficacy and birth related PTSD symptoms: an online childbirth education randomised controlled trial for mothers. 分娩自我效能与分娩相关创伤后应激障碍症状:针对母亲的在线分娩教育随机对照试验。
IF 2.8 2区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2024-10-12 DOI: 10.1186/s12884-024-06873-6
Lucy J Frankham, Einar B Thorsteinsson, Warren Bartik

Background: This study evaluated an online childbirth education course on childbirth self-efficacy and, subsequent birth related posttraumatic stress disorder (PTSD) symptoms and mother-infant relationship quality.

Method: Three group (intervention, passive control, active control) parallel randomised controlled trial. Groups were assigned using computer generated random allocation. For the passive control group participants were instructed to carry on with whatever they were currently undertaking with their pregnancy, while the active control group were asked to read a booklet comprised of twelve birth stories. The purpose of the active control was to check if the act of having an activity to complete would influence outcomes. For the online course group (intervention) participants were asked to complete the online version of a birthing course designed by She Births®. One hundred and twenty-five women residing in Australia between 12 and 24 weeks pregnant were recruited online. Participants were asked to complete their required activity between 24 and 36 weeks pregnant. Childbirth self-efficacy scores were tested pre and post intervention (time one and time 2), PTSD symptoms and mother-infant relationship quality were tested at six weeks and six months postnatal.

Results: There was no significant interaction by group for childbirth self-efficacy scores. Mean difference scores at time one (pre-intervention) and time two (post-intervention) for each group indicated a trend in the online group towards higher childbirth self-efficacy compared with the two control groups. The main effect of group on birth related PTSD scores was not statically significant at six weeks postnatal or at six months postnatal. The main effect of group on mother-infant relationship scores was not statically significant at six weeks postnatal or six months postnatal.

Conclusions: Trends showed childbirth self-efficacy scores to be higher in the intervention group compared with the two control groups, demonstrating effectiveness for the intervention. Paradoxically, PTSD scores were higher in the intervention group compared with the two control groups and therefore also reported poorer mother-infant relationship quality. External factors may be more important than childbirth self-efficacy highlighting the need for a holistic approach that addresses systemic and socio-political influences to improve communication, autonomy, and respectful maternity care.

Trial registration: This trial was retrospectively registered with the Australian New Zealand Clinical Trials Registry number: ACTRN12624000241538 on March 11, 2024.

背景:本研究评估了在线分娩教育课程对分娩自我效能以及随后与分娩相关的创伤后应激障碍(PTSD)症状和母婴关系质量的影响:本研究评估了在线分娩教育课程对分娩自我效能、随后与分娩相关的创伤后应激障碍(PTSD)症状和母婴关系质量的影响:三组(干预组、被动对照组、主动对照组)平行随机对照试验。采用计算机生成的随机分配法分配各组。被动对照组的参与者被要求继续进行目前正在进行的孕期活动,而主动对照组的参与者则被要求阅读一本由 12 个分娩故事组成的小册子。主动对照组的目的是检查要完成的活动是否会影响结果。在线课程组(干预)的参与者被要求完成由 She Births® 设计的在线版分娩课程。我们在网上招募了 125 名居住在澳大利亚、怀孕 12-24 周的妇女。参与者被要求在怀孕 24 到 36 周之间完成规定的活动。在干预前和干预后(第一时间和第二时间)测试了分娩自我效能得分,在产后六周和六个月测试了创伤后应激障碍症状和母婴关系质量:在分娩自我效能得分方面,各组之间没有明显的交互作用。各组在第一时间(干预前)和第二时间(干预后)的平均差异得分表明,与两个对照组相比,在线组的分娩自我效能感呈上升趋势。组别对分娩相关创伤后应激障碍得分的主效应在产后六周或产后六个月时均无统计学意义。组别对母婴关系得分的主效应在产后六周和产后六个月均无统计学意义:趋势表明,与两个对照组相比,干预组的分娩自我效能感得分更高,这表明了干预的有效性。矛盾的是,与两个对照组相比,干预组的创伤后应激障碍得分更高,因此母婴关系质量也更差。外部因素可能比分娩自我效能感更为重要,这凸显出需要采取综合方法来解决系统性和社会政治影响因素,以改善沟通、自主性和尊重产妇的护理:该试验已在澳大利亚-新西兰临床试验注册中心进行了回顾性注册,注册号为 ACTRN1262400024:ACTRN12624000241538。
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引用次数: 0
A national study on maternal vomiting during pregnancy in Iran: prevalence, determinants, adverse birth outcomes, and the trend. 关于伊朗孕产妇妊娠呕吐的全国性研究:发病率、决定因素、不良分娩结果和趋势。
IF 2.8 2区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2024-10-12 DOI: 10.1186/s12884-024-06880-7
Sima Afrashte, Mahmoud Hajipour, Mitra Darbandi, Mostafa Dianatinasab, Shahab Rezaeian

Background: Nausea and vomiting during pregnancy (NVP) is one of the most common complication of pregnancy. The present study was aimed to determine the association between vomiting during pregnancy and adverse birth outcomes.

Methods: A cross-sectional study was conducted on 3649 pregnant women across 11 provinces of Iran. Cluster sampling method was used to select samples and data collection was done using family record and face-to-face interviews. Data were analyzed by logistic regression, using STATA14.2 software.

Results: The prevalence of vomiting during pregnancy was 9.7% (95% CI: 8.8, 10.7), with an increasing trend by birth cohort. After adjusting for other confounders, the prevalence of vomiting revealed a decreasing trend by body mass index (OR = 0.63, 95%CI: 0.53, 0.78, P-trend < 0.001). In addition, long inter-pregnancy interval (IPI) significantly increased the odds of NVP (ORIPI of 1-3 year=2.42, ORIPI of >3 year=1.63). Multivariate analyses showed that the odds of stillbirth (AOR = 1.61, 95% CI: 1.17, 2.19) and the odds of infant mortality (AOR = 1.78, 95% CI: 1.29, 2.45) were significantly increased in women with daily vomiting during pregnancy. The odds of vomiting during pregnancy was significantly shown to reduce the odds of abortion by 45%.

Conclusion: The prevalence of NVP was shown to have an increasing trend in Iran. This complication is associated with many adverse health outcomes during pregnancy and negatively affect maternal and fetal health. Given the importance of pregnancy period, nutrition education and increase the awareness of pregnant women towards NVP, especially pre-pregnancy training is suggested.

背景:妊娠期恶心和呕吐(NVP)是妊娠期最常见的并发症之一。本研究旨在确定孕期呕吐与不良分娩结局之间的关系:方法:对伊朗 11 个省的 3649 名孕妇进行了横断面研究。采用聚类抽样法选取样本,并通过家庭记录和面对面访谈收集数据。数据采用 STATA14.2 软件进行逻辑回归分析:结果:孕期呕吐的发生率为 9.7%(95% CI:8.8-10.7),并呈上升趋势。在对其他混杂因素进行调整后,呕吐发生率随体重指数的变化呈下降趋势(OR=0.63,95%CI:0.53,0.78,P-趋势为1-3岁的IPI=2.42,>3岁的ORIPI=1.63)。多变量分析显示,孕期每天呕吐的妇女死胎几率(AOR = 1.61,95% CI:1.17,2.19)和婴儿死亡几率(AOR = 1.78,95% CI:1.29,2.45)显著增加。怀孕期间呕吐的几率明显降低了 45% 的流产几率:结论:在伊朗,NVP 的发病率呈上升趋势。这种并发症与妊娠期间的许多不良健康结果有关,并对孕产妇和胎儿的健康产生负面影响。鉴于孕期的重要性,建议开展营养教育,提高孕妇对 NVP 的认识,尤其是孕前培训。
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引用次数: 0
Fluctuation trend of inflammatory indexes related to gestational diabetes mellitus from second trimester to third trimester of pregnancy. 与妊娠糖尿病有关的炎症指数在妊娠第二个三个月至第三个三个月的波动趋势。
IF 2.8 2区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2024-10-12 DOI: 10.1186/s12884-024-06846-9
Mingming Xu, Linlin Tang, Yaping Wang

Objective: This study aims to assess the prognostic and diagnostic value of inflammatory indexes related to gestational diabetes mellitus (GDM) from the second trimester to the third trimester of pregnancy.

Materials and methods: In this study, we randomly selected 65 pregnant women diagnosed with GDM at our hospital from December 2022 to June 2023 to form the GDM group (n = 65). Additionally, 65 pregnant women at the same gestational weeks without GDM were selected as the Normal group (n = 65). We collected gestational information and serum samples at 24 and 36 weeks of gestation from the participants. The levels of NLRP3, IL-1Ra, and TBP-2 were determined using enzyme-linked immunosorbent assay (ELISA) to explore their changes during pregnancy. Further, this study analyzed the changes in the levels of NLRP3, IL-1Ra, and TBP-2 at 24 and 36 weeks of gestation in GDM patients and their correlation with gestational diabetes mellitus.

Results: The study showed that pre-pregnancy body mass index (BMI), neonatal weight, gestational hypertension, and macrosomia are significantly associated with the occurrence of GDM (P < 0.05). Statistical analysis comparing the normal and GDM groups found no significant changes in the levels of NLRP3, IL-1Ra, and TBP-2 with the progression of gestation in the normal group. In contrast, in the GDM group, the levels of IL-1Ra in serum samples at 24 and 36 weeks were significantly increased (P < 0.05) while the levels of NLRP3 and TBP-2 were significantly reduced (P < 0.05). At 36 weeks, there was a positive correlation between the levels of NLRP3, IL-1Ra, and TBP-2. Compared to the normal group, the overall levels of NLRP3, IL-1Ra, and TBP-2 in the GDM group were lower (P < 0.05) and the weight of the newborns was significantly correlated with these three indicators (P < 0.05), specifically newborn weight increased with the levels of NLRP3 and TBP-2 but decreased with the increase of IL-1Ra (P < 0.05). Multifactorial logistic regression analysis further revealed that NLRP3 is an independent factor influencing GDM (P < 0.05). ROC curve analysis of the NLRP3 level at 24 weeks of gestation found that NLRP3 has a good value in predicting GDM (AUC = 0.720, 95%CI 0.630-0.809, P < 0.001) and the combined prediction of NLRP3, IL-1Ra, and TBP-2 also showed a good predictive value for GDM.

Conclusion: The changes in NLRP3, IL-1Ra, and TBP-2 persisted throughout the 24 to 36 weeks of gestation, playing an important role in predicting the occurrence of GDM and the weight of the newborn.

研究目的本研究旨在评估与妊娠期糖尿病(GDM)相关的炎症指标在妊娠期第二个三个月至第三个三个月的预后和诊断价值:在本研究中,我们随机选取了2022年12月至2023年6月在我院确诊为GDM的65名孕妇组成GDM组(n = 65)。此外,我们还选取了 65 名孕周相同但未患 GDM 的孕妇作为正常组(n = 65)。我们收集了参与者的妊娠信息以及妊娠 24 周和 36 周时的血清样本。我们使用酶联免疫吸附试验(ELISA)测定了NLRP3、IL-1Ra和TBP-2的水平,以探讨它们在孕期的变化。此外,该研究还分析了 GDM 患者在妊娠 24 周和 36 周时 NLRP3、IL-1Ra 和 TBP-2 水平的变化及其与妊娠糖尿病的相关性:研究结果表明,孕前体重指数(BMI)、新生儿体重、妊娠高血压和巨大儿与 GDM 的发生显著相关(PNLRP3、IL-1Ra 和 TBP-2 的变化在妊娠 24 至 36 周期间持续存在,在预测 GDM 的发生和新生儿体重方面发挥着重要作用。
{"title":"Fluctuation trend of inflammatory indexes related to gestational diabetes mellitus from second trimester to third trimester of pregnancy.","authors":"Mingming Xu, Linlin Tang, Yaping Wang","doi":"10.1186/s12884-024-06846-9","DOIUrl":"https://doi.org/10.1186/s12884-024-06846-9","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to assess the prognostic and diagnostic value of inflammatory indexes related to gestational diabetes mellitus (GDM) from the second trimester to the third trimester of pregnancy.</p><p><strong>Materials and methods: </strong>In this study, we randomly selected 65 pregnant women diagnosed with GDM at our hospital from December 2022 to June 2023 to form the GDM group (n = 65). Additionally, 65 pregnant women at the same gestational weeks without GDM were selected as the Normal group (n = 65). We collected gestational information and serum samples at 24 and 36 weeks of gestation from the participants. The levels of NLRP3, IL-1Ra, and TBP-2 were determined using enzyme-linked immunosorbent assay (ELISA) to explore their changes during pregnancy. Further, this study analyzed the changes in the levels of NLRP3, IL-1Ra, and TBP-2 at 24 and 36 weeks of gestation in GDM patients and their correlation with gestational diabetes mellitus.</p><p><strong>Results: </strong>The study showed that pre-pregnancy body mass index (BMI), neonatal weight, gestational hypertension, and macrosomia are significantly associated with the occurrence of GDM (P < 0.05). Statistical analysis comparing the normal and GDM groups found no significant changes in the levels of NLRP3, IL-1Ra, and TBP-2 with the progression of gestation in the normal group. In contrast, in the GDM group, the levels of IL-1Ra in serum samples at 24 and 36 weeks were significantly increased (P < 0.05) while the levels of NLRP3 and TBP-2 were significantly reduced (P < 0.05). At 36 weeks, there was a positive correlation between the levels of NLRP3, IL-1Ra, and TBP-2. Compared to the normal group, the overall levels of NLRP3, IL-1Ra, and TBP-2 in the GDM group were lower (P < 0.05) and the weight of the newborns was significantly correlated with these three indicators (P < 0.05), specifically newborn weight increased with the levels of NLRP3 and TBP-2 but decreased with the increase of IL-1Ra (P < 0.05). Multifactorial logistic regression analysis further revealed that NLRP3 is an independent factor influencing GDM (P < 0.05). ROC curve analysis of the NLRP3 level at 24 weeks of gestation found that NLRP3 has a good value in predicting GDM (AUC = 0.720, 95%CI 0.630-0.809, P < 0.001) and the combined prediction of NLRP3, IL-1Ra, and TBP-2 also showed a good predictive value for GDM.</p><p><strong>Conclusion: </strong>The changes in NLRP3, IL-1Ra, and TBP-2 persisted throughout the 24 to 36 weeks of gestation, playing an important role in predicting the occurrence of GDM and the weight of the newborn.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11470678/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142457457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Utilizing the glucose challenge test during pregnancy as a predictor of future diabetes risk. 利用孕期葡萄糖挑战测试预测未来糖尿病风险。
IF 2.8 2区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2024-10-11 DOI: 10.1186/s12884-024-06874-5
Meir Frankel, Noa Tsur, Rena Pollack, Anat Tsur

Background: Gestational Diabetes Mellitus (GDM) presents a significant health concern during pregnancy, predisposing individuals to future diabetes. Despite established postpartum diabetes screening guidelines, adherence to follow-up remains inadequate.

Aims: This study aimed to assess the predictive value of the 50-gram glucose challenge test (GCT) for post-pregnancy diabetes development.

Materials and methods: A population-based retrospective cohort study was conducted on pregnant women aged 18-45 who underwent GCT screening between November 2007 and July 2017 in a large Israeli community medical organization. Baseline characteristics, GCT results, and diabetes development during follow-up were analyzed using univariate and multivariate Cox regression analyses.

Results: Among 8,675 women included, 2.4% developed diabetes over a median follow-up of 73.23 months. Elevated GCT results correlated with a higher risk of future diabetes, with a 4% rise in risk per 1 mg/dL increase in glucose above 140 mg/dL. Multivariate analysis revealed a 60-fold rise in the risk of future diabetes in women with GCT results ≥ 200 mg/dL compared to those with GCT < 140 mg/dL, adjusting for age, body mass index, pre-pregnancy glucose, cholesterol, and triglycerides. A GCT result between 140 and 199 mg/dL was a predictor of future diabetes, even when adjusted for GDM based on a subsequent GTT if performed.

Conclusions: GCT results during pregnancy strongly predict future diabetes development, with higher GCT values significantly increasing risk. Recognizing abnormal GCT results as indicative of a prediabetic state offers a practical approach for risk stratification, facilitating early diagnosis, and intervention in post-pregnancy care.

背景:妊娠期糖尿病(GDM)是妊娠期间的一个重大健康问题,易使孕妇将来患上糖尿病。目的:本研究旨在评估 50 克葡萄糖挑战试验(GCT)对妊娠后糖尿病发展的预测价值:一项基于人群的回顾性队列研究针对 2007 年 11 月至 2017 年 7 月期间在以色列一家大型社区医疗机构接受 GCT 筛查的 18-45 岁孕妇。采用单变量和多变量考克斯回归分析法对基线特征、GCT结果和随访期间的糖尿病发展情况进行了分析:在纳入的8675名女性中,2.4%的女性在中位73.23个月的随访期间患上了糖尿病。GCT 结果升高与未来罹患糖尿病的风险升高相关,血糖每升高 1 毫克/分升(140 毫克/分升),罹患糖尿病的风险就升高 4%。多变量分析显示,与 GCT 结果≥ 200 mg/dL 的妇女相比,GCT 结果≥ 200 mg/dL 的妇女未来患糖尿病的风险增加了 60 倍:孕期 GCT 结果可有力预测未来糖尿病的发展,GCT 值越高,风险越大。将异常的 GCT 结果视为糖尿病前期状态的指标,为风险分层、早期诊断和孕后护理干预提供了一种实用的方法。
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引用次数: 0
A rare cause of echogenic kidneys with oligohydramnios in the fetus: report of two different cases. 胎儿肾脏回声异常伴少水胎儿的罕见病因:两个不同病例的报告。
IF 2.8 2区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2024-10-11 DOI: 10.1186/s12884-024-06861-w
Tim Phetthong, Krit Achaloetvaranon, Sanpon Diawtipsukon

Background: Prenatal ultrasound findings of fetal bilateral echogenic kidneys accompanied by oligohydramnios can be highly stressful for both pregnant women and physicians. The diversity of underlying causes makes it challenging to confirm a prenatal diagnosis, predict postnatal outcomes, and counsel regarding recurrence risks in future pregnancies.

Case presentation: We report two cases of abnormal fetal echogenic kidneys with oligohydramnios detected in the early third trimester. Autosomal recessive polycystic kidney disease (ARPKD), a rare genetic syndrome, was initially suspected in both cases. However, postnatal diagnoses differed: the first case was confirmed as glomerulocystic kidney disease (GCKD) through renal pathology, while the second case was diagnosed as ARPKD with a compound heterozygous likely pathogenic PKHD1 mutation.

Conclusion: Prenatal diagnosis of fetal echogenic kidneys with oligohydramnios should prioritize accurate diagnosis. Given the differences in the clinical spectrum, GCKD should be considered a differential diagnosis for this condition, particularly ARPKD. This study highlights the importance and benefits of molecular diagnosis and postnatal renal pathology for precise diagnosis and effective counseling.

背景:产前超声检查发现胎儿双侧肾脏回声不全并伴有少尿,这对孕妇和医生来说都是极大的压力。潜在病因的多样性使得确诊产前诊断、预测产后结果以及就未来妊娠中的复发风险提供建议变得非常具有挑战性:我们报告了两例在妊娠早期三个月发现的胎儿异常回声肾和少水肿。常染色体隐性多囊肾病(ARPKD)是一种罕见的遗传综合征,两例病例最初都被怀疑患有该病。然而,产后诊断结果却不同:第一个病例通过肾脏病理证实为肾小球囊肿性肾病(GCKD),而第二个病例则被诊断为ARPKD,并伴有可能致病的PKHD1复合杂合子突变:结论:胎儿回声性肾脏少尿症的产前诊断应优先考虑准确诊断。鉴于临床谱系的差异,GCKD 应被视为该病症的鉴别诊断,尤其是 ARPKD。本研究强调了分子诊断和产后肾脏病理学对精确诊断和有效咨询的重要性和益处。
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引用次数: 0
Secular variation and risk factors of preterm birth in Hainan, the Free Trade Port in China from 2010 to 2021. 2010 至 2021 年中国自由贸易港海南早产的季节性变化和风险因素。
IF 2.8 2区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2024-10-10 DOI: 10.1186/s12884-024-06826-z
Qing Luo, Weijia Wu, Chao Li, Anping Zhao, Dan Zhao, Chuican Huang, Lichun Fan

Objectives: Preterm delivery rates have increased obviously worldwide over the past decade, yet reliable epidemiological studies on the incidence of preterm birth and temporal trends are not available in Hainan, The Free Trade Port in China. We aimed to describe the rate of preterm birth and trends between 2010 and 2021 and to primarily explore risk factors associated with preterm birth in Hainan, China.

Methods: This was an observational study was based on data from the Hainan Provincial Birth Certificate System (HPBCS) for live births between 1 January 2010 and 31 December 2021. We included pregnancies resulting in at least one live birth, with newborns born at a gestational age of 28 weeks or greater, or with a birth weight of 1000 g or more. The outcome were preterm birth rates and their trends over time. Potential risk factors were collected, including infant gender, maternal age, paternal age, maternal ethnicity, paternal ethnicity, home address, and single or multiple pregnancies. The logistic regression model was used to assess the relationship between preterm birth and potential risk factors.

Results: A total of 1,537,239 live births and 86,328 preterm births were investigated, giving a total preterm birth rate of 5.62%. The overall preterm birth rate increased from 4.47% in 2010 to 7.12% in 2021 (compound annual growth rate [CAGR] 4.32). The CAGR of late preterm birth is consistent with the overall preterm birth rate (4.32%). The fastest growth is observed in the rate of very preterm births (5.53%), while the rate of moderate preterm births exhibits the slowest growth (3.87%). Infant gender, multiple pregnancy, home address, parental age, and ethnicity had significant effects on preterm birth.

Conclusion: The preterm birth rate was increasing year by year from 2010 to 2021 in Hainan, The Free Trade Port in China. Incidence of preterm births in Hainan Province in relation to multiple pregnancies, infant sex, parental age, parental race and residential address.

目的:在过去的十年中,早产率在全球范围内明显上升,但在中国自由贸易港海南,还没有关于早产发生率和时间趋势的可靠流行病学研究。我们旨在描述 2010 年至 2021 年间中国海南的早产率及其趋势,并主要探讨与早产相关的风险因素:这是一项观察性研究,基于海南省出生证明系统(HPBCS)中 2010 年 1 月 1 日至 2021 年 12 月 31 日期间的活产婴儿数据。研究对象包括至少有一例活产、胎龄大于或等于 28 周、出生体重大于或等于 1000 克的孕妇。结果是早产率及其随时间变化的趋势。收集的潜在风险因素包括婴儿性别、母亲年龄、父亲年龄、母亲种族、父亲种族、家庭住址以及单胎或多胎妊娠。采用逻辑回归模型评估早产与潜在风险因素之间的关系:共调查了 1,537,239 例活产和 86,328 例早产,总早产率为 5.62%。总早产率从 2010 年的 4.47% 上升至 2021 年的 7.12%(复合年增长率 [CAGR]为 4.32)。晚期早产的复合年增长率与总体早产率(4.32%)一致。极度早产率增长最快(5.53%),而中度早产率增长最慢(3.87%)。婴儿性别、多胎妊娠、家庭住址、父母年龄和种族对早产有显著影响:从 2010 年到 2021 年,中国自由贸易港海南的早产率逐年上升。海南省早产发生率与多胎妊娠、婴儿性别、父母年龄、父母种族和居住地址有关。
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引用次数: 0
Factors associated with mortality and neurodevelopmental impairment at 12 months in asphyxiated newborns: a retrospective cohort study in rural Tanzania from January 2019 to June 2022. 与窒息新生儿 12 个月时的死亡率和神经发育障碍相关的因素:2019 年 1 月至 2022 年 6 月在坦桑尼亚农村地区开展的一项回顾性队列研究。
IF 2.8 2区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2024-10-10 DOI: 10.1186/s12884-024-06837-w
Elisa Manzini, Martina Borellini, Paolo Belardi, Evodia Mlawa, Emmanuel Kadinde, Christina Mwibuka, Francesco Cavallin, Daniele Trevisanuto, Agnese Suppiej

Background: Worldwide about 2.3 million newborns still die in the neonatal period and the majority occurs in low- and middle-income countries (LMICs). Intrapartum-related events account for 24% of neonatal mortality. Of these events, intrapartum birth asphyxia with subsequent neonatal encephalopathy is the main cause of child disabilities in LMICs. Data on neurodevelopmental outcome and early risk factors are still missing in LMICs. This study aimed at investigating the factors associated with mortality, risk of neurodevelopmental impairment and adherence to follow-up among asphyxiated newborns in rural Tanzania.

Methods: This retrospective observational cohort study investigated mortality, neurodevelopmental risk and adherence to follow-up among asphyxiated newborns who were admitted to Tosamaganga Hospital (Tanzania) from January 2019 to June 2022. Neurodevelopmental impairment was assessed using standardized Hammersmith neurologic examination. Admission criteria were Apgar score < 7 at 5 min of life and birth weight > 1500 g. Babies with clinically visible congenital malformations were excluded. Comparisons between groups were performed using the Mann-Whitney test, the Chi-square test, and the Fisher test.

Results: Mortality was 19.1% (57/298 newborns) and was associated with outborn (p < 0.0001), age at admission (p = 0.02), lower Apgar score at 5 min (p = 0.003), convulsions (p < 0.0001) and intravenous fluids (IV) (p = 0.003). Most patients (85.6%) were lost to follow-up after a median of 1 visit (IQR 0-2). Low adherence to follow-up was associated with female sex (p = 0.005). The risk of neurodevelopmental impairment at the last visit was associated with longer travel time between household and hospital (p = 0.03), female sex (p = 0.04), convulsions (p = 0.007), respiratory distress (p = 0.01), administration of IV fluids (p = 0.04), prolonged oxygen therapy (p = 0.004), prolonged hospital stay (p = 0.0007) and inappropriate growth during follow-up (p = 0.0002).

Conclusions: Our findings demonstrated that mortality among asphyxiated newborns in a rural hospital in Tanzania remains high. Additionally, distance from home to hospital and sex of the newborn correlated to higher risks of neurodevelopmental impairment. Educational interventions among the population about the importance of regular health assessment are needed to improve adherence to follow-up and for preventive purposes. Future studies should investigate the role of factors affecting the adherence to follow-up.

背景:全世界仍有约 230 万新生儿死于新生儿期,其中大部分发生在中低收入国家(LMICs)。产期相关事件占新生儿死亡率的 24%。在这些事件中,产时窒息和随后的新生儿脑病是导致低收入和中等收入国家儿童残疾的主要原因。在低收入国家,有关神经发育结果和早期风险因素的数据仍然缺失。本研究旨在调查坦桑尼亚农村地区窒息新生儿死亡率、神经发育障碍风险和坚持随访的相关因素:这项回顾性观察队列研究调查了2019年1月至2022年6月期间入住托萨马甘加医院(坦桑尼亚)的窒息新生儿的死亡率、神经发育风险和坚持随访的情况。使用标准化的哈默史密斯神经系统检查评估神经发育障碍。入院标准为Apgar评分1500克。组间比较采用曼-惠特尼检验、卡方检验和费舍尔检验:结果:死亡率为 19.1%(57/298 名新生儿),与新生儿出生率有关(p 结论:我们的研究结果表明,新生儿出生率越低,死亡率越高:我们的研究结果表明,坦桑尼亚一家农村医院的新生儿窒息死亡率仍然很高。此外,从家到医院的距离和新生儿的性别与较高的神经发育障碍风险相关。有必要在居民中开展有关定期健康评估重要性的教育干预,以提高随访的依从性并达到预防目的。未来的研究应调查影响坚持随访的因素的作用。
{"title":"Factors associated with mortality and neurodevelopmental impairment at 12 months in asphyxiated newborns: a retrospective cohort study in rural Tanzania from January 2019 to June 2022.","authors":"Elisa Manzini, Martina Borellini, Paolo Belardi, Evodia Mlawa, Emmanuel Kadinde, Christina Mwibuka, Francesco Cavallin, Daniele Trevisanuto, Agnese Suppiej","doi":"10.1186/s12884-024-06837-w","DOIUrl":"10.1186/s12884-024-06837-w","url":null,"abstract":"<p><strong>Background: </strong>Worldwide about 2.3 million newborns still die in the neonatal period and the majority occurs in low- and middle-income countries (LMICs). Intrapartum-related events account for 24% of neonatal mortality. Of these events, intrapartum birth asphyxia with subsequent neonatal encephalopathy is the main cause of child disabilities in LMICs. Data on neurodevelopmental outcome and early risk factors are still missing in LMICs. This study aimed at investigating the factors associated with mortality, risk of neurodevelopmental impairment and adherence to follow-up among asphyxiated newborns in rural Tanzania.</p><p><strong>Methods: </strong>This retrospective observational cohort study investigated mortality, neurodevelopmental risk and adherence to follow-up among asphyxiated newborns who were admitted to Tosamaganga Hospital (Tanzania) from January 2019 to June 2022. Neurodevelopmental impairment was assessed using standardized Hammersmith neurologic examination. Admission criteria were Apgar score < 7 at 5 min of life and birth weight > 1500 g. Babies with clinically visible congenital malformations were excluded. Comparisons between groups were performed using the Mann-Whitney test, the Chi-square test, and the Fisher test.</p><p><strong>Results: </strong>Mortality was 19.1% (57/298 newborns) and was associated with outborn (p < 0.0001), age at admission (p = 0.02), lower Apgar score at 5 min (p = 0.003), convulsions (p < 0.0001) and intravenous fluids (IV) (p = 0.003). Most patients (85.6%) were lost to follow-up after a median of 1 visit (IQR 0-2). Low adherence to follow-up was associated with female sex (p = 0.005). The risk of neurodevelopmental impairment at the last visit was associated with longer travel time between household and hospital (p = 0.03), female sex (p = 0.04), convulsions (p = 0.007), respiratory distress (p = 0.01), administration of IV fluids (p = 0.04), prolonged oxygen therapy (p = 0.004), prolonged hospital stay (p = 0.0007) and inappropriate growth during follow-up (p = 0.0002).</p><p><strong>Conclusions: </strong>Our findings demonstrated that mortality among asphyxiated newborns in a rural hospital in Tanzania remains high. Additionally, distance from home to hospital and sex of the newborn correlated to higher risks of neurodevelopmental impairment. Educational interventions among the population about the importance of regular health assessment are needed to improve adherence to follow-up and for preventive purposes. Future studies should investigate the role of factors affecting the adherence to follow-up.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11468089/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142399280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bovine aortic arch: a potential indicator that may not serve in prenatal diagnosis - a study based on fetal anatomy, genetics, and postnatal clinical outcomes. 牛主动脉弓:可能无法用于产前诊断的潜在指标--基于胎儿解剖学、遗传学和产后临床结果的研究。
IF 2.8 2区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2024-10-10 DOI: 10.1186/s12884-024-06852-x
Yu Liu, Chuanfen Gao, Yi Zhou, Sheng Zhao, Xiufang Shuai, Enfa Zhao, Feng Chen, Chaoxue Zhang

Objective: To investigate the structural abnormalities, genetic results, and postnatal clinical outcomes of fetuses with bovine aortic arch (Bovine Aortic Arch, BAA) to provide a basis for prenatal counseling and management.

Methods: A retrospective analysis was conducted on 216 fetuses diagnosed with bovine aortic arch through prenatal ultrasound screening at the First Affiliated Hospital of Anhui Medical University and the No.901 Hospital of the Joint Service of the People's Liberation Army from January 2019 to February 2023. Their family history of genetic diseases, prenatal screening results, and postnatal follow-up data were collected. The fetuses were divided into an isolated BAA group (n = 192) and a non-isolated BAA group (n = 24). Chromosomal karyotyping and copy number variation (CNV) testing were conducted, and statistical analysis was performed using SPSS 22.0 software.

Results: Of the 216 fetuses with BAA, 192 were isolated BAA (88.89%), and 24 were non-isolated BAA (11.11%). Among the isolated BAA fetuses, only 1 case (0.52%) had chromosomal karyotype and pathogenic CNV abnormalities. Among the non-isolated BAA fetuses, 4 cases (16.67%) had chromosomal or CNV abnormalities, but the overall risk was low. The postnatal outcomes of isolated BAA fetuses were good (99.48%), while 79.17% of non-isolated BAA fetuses had good postnatal outcomes.

Conclusion: Most BAA fetuses are isolated, with a very low incidence of chromosomal abnormalities and pathogenic CNVs, and have good postnatal outcomes. The clinical value of isolated BAA is limited, and invasive prenatal diagnosis is not recommended for low-risk populations. Prenatal screening should focus on the risk of concurrent severe structural anomalies and chromosomal abnormalities.

目的研究牛主动脉弓(BAA)胎儿的结构异常、遗传结果和产后临床结局,为产前咨询和管理提供依据:方法:对2019年1月至2023年2月在安徽医科大学第一附属医院和中国人民解放军联勤部第901医院通过产前超声筛查确诊的216例牛主动脉弓胎儿进行回顾性分析。收集了他们的遗传病家族史、产前筛查结果和产后随访资料。胎儿被分为分离型BAA组(n = 192)和非分离型BAA组(n = 24)。进行染色体核型和拷贝数变异(CNV)检测,并使用 SPSS 22.0 软件进行统计分析:在 216 个 BAA 胎儿中,192 个为分离型 BAA(88.89%),24 个为非分离型 BAA(11.11%)。在分离型 BAA 胎儿中,只有 1 例(0.52%)存在染色体核型和致病性 CNV 异常。在非孤立型 BAA 胎儿中,4 例(16.67%)有染色体或 CNV 异常,但总体风险较低。分离型 BAA 胎儿的产后结局良好(99.48%),而非分离型 BAA 胎儿的产后结局良好率为 79.17%:结论:大多数 BAA 胎儿是孤立的,染色体异常和致病 CNV 的发生率极低,且产后预后良好。分离性 BAA 的临床价值有限,不建议对低风险人群进行侵入性产前诊断。产前筛查应重点关注并发严重结构异常和染色体异常的风险。
{"title":"Bovine aortic arch: a potential indicator that may not serve in prenatal diagnosis - a study based on fetal anatomy, genetics, and postnatal clinical outcomes.","authors":"Yu Liu, Chuanfen Gao, Yi Zhou, Sheng Zhao, Xiufang Shuai, Enfa Zhao, Feng Chen, Chaoxue Zhang","doi":"10.1186/s12884-024-06852-x","DOIUrl":"10.1186/s12884-024-06852-x","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the structural abnormalities, genetic results, and postnatal clinical outcomes of fetuses with bovine aortic arch (Bovine Aortic Arch, BAA) to provide a basis for prenatal counseling and management.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 216 fetuses diagnosed with bovine aortic arch through prenatal ultrasound screening at the First Affiliated Hospital of Anhui Medical University and the No.901 Hospital of the Joint Service of the People's Liberation Army from January 2019 to February 2023. Their family history of genetic diseases, prenatal screening results, and postnatal follow-up data were collected. The fetuses were divided into an isolated BAA group (n = 192) and a non-isolated BAA group (n = 24). Chromosomal karyotyping and copy number variation (CNV) testing were conducted, and statistical analysis was performed using SPSS 22.0 software.</p><p><strong>Results: </strong>Of the 216 fetuses with BAA, 192 were isolated BAA (88.89%), and 24 were non-isolated BAA (11.11%). Among the isolated BAA fetuses, only 1 case (0.52%) had chromosomal karyotype and pathogenic CNV abnormalities. Among the non-isolated BAA fetuses, 4 cases (16.67%) had chromosomal or CNV abnormalities, but the overall risk was low. The postnatal outcomes of isolated BAA fetuses were good (99.48%), while 79.17% of non-isolated BAA fetuses had good postnatal outcomes.</p><p><strong>Conclusion: </strong>Most BAA fetuses are isolated, with a very low incidence of chromosomal abnormalities and pathogenic CNVs, and have good postnatal outcomes. The clinical value of isolated BAA is limited, and invasive prenatal diagnosis is not recommended for low-risk populations. Prenatal screening should focus on the risk of concurrent severe structural anomalies and chromosomal abnormalities.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11468462/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142399279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Profiling intimate partner violence in booked pregnant women at Alex Ekwueme Federal University Teaching Hospital Abakaliki and associated puerperal depressive sequelae: a prospective cohort study. 剖析阿巴卡利基亚历克斯-埃克伍梅联邦大学教学医院预约孕妇中的亲密伴侣暴力及相关产褥期抑郁后遗症:一项前瞻性队列研究。
IF 2.8 2区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2024-10-10 DOI: 10.1186/s12884-024-06869-2
Amuchechukwu V Nwafor, Odidika Ugochukwu J Umeora, Arinze C Ikeotuonye, Bobby C Iwe, Justus N Eze, Leonard O Ajah, Christian C Anikwe, Chidi O U Esike, Francis C Okoroafor, Okey Mbanefo, Uchenna N Nwaedu
<p><strong>Background: </strong>Intimate partner violence (IPV) in pregnancy is a physical, sexual, psychological or economic harm by a current or former partner or spouse on a pregnant woman. It is a global public health problem that is common but underreported. Women are at increased risk of psychiatric illness in pregnancy and after delivery with the risk of major depressive disorder being highest during the postpartum period. Intimate partner violence in pregnancy may worsen this problem.</p><p><strong>Objectives: </strong>The objectives of the study were to determine the prevalence of intimate partner violence (IPV) in pregnancy, incidence of postpartum depression and the relationship between intimate partner violence, delivery outcomes and postpartum depression among booked pregnant women at Alex Ekwueme Federal University Teaching Hospital Abakaliki, Ebonyi state, Nigeria (AEFUTHA).</p><p><strong>Study design: </strong>This study was a prospective cohort study.</p><p><strong>Setting: </strong>The antenatal clinic, antenatal ward, labour ward, postpartum clinic and under five clinic of Alex Ekwueme Federal University Teaching Hospital Abakaliki, Ebonyi state, Nigeria were used for the study.</p><p><strong>Method: </strong>One hundred and thirty-seven booked pregnant women that received antenatal care at AEFUTHA who met the inclusion criteria and consented to the study, were recruited from 37 weeks to 41 weeks gestation and screened for intimate partner violence and depression. Those with depression were referred for treatment while those that met the inclusion criteria were followed up to delivery and the delivery outcomes documented. They were also followed up to six weeks postpartum when they were screened for postpartum depression. Data were collated, tabulated and then statistically analysed using Statistical Package for Social Science (SPSS) software (version 25, Chicago II, USA). Numerical variables including participant's age, parity and gestational age were presented as mean, median, frequencies and standard deviation (Mean ± S.D), while categorical variables including occupation, level of education, social class and family type were presented as numbers and percentages. Chi-square test (X<sup>2</sup>) and relative risk was used for comparison between groups for categorical variables while Fisher's exact test was used when Chi-square test (X<sup>2</sup>) was not suitable. Binary regression analysis was used to determine the relationship between intimate partner violence and postpartum depression. A P value of ˂0.05 is considered statistically significant.</p><p><strong>Results: </strong>The prevalence of intimate partner violence was 52.6%, as 72 out of the 137 women recruited endured intimate partner violence. The major risk factors for intimate partner violence in the study were low level of education, low social class, polygamy and unemployment. The general incidence of postpartum depression was 29.93% while the incidence among w
背景:孕期亲密伴侣暴力(IPV)是指现任或前任伴侣或配偶对孕妇造成的身体、性、心理或经济伤害。这是一个全球性的公共卫生问题,很常见,但却很少被报道。妇女在孕期和产后患精神疾病的风险增加,产后患重度抑郁症的风险最高。孕期亲密伴侣暴力可能会加剧这一问题:研究目的:本研究旨在确定尼日利亚埃邦伊州阿巴卡利基亚历克斯-埃克乌梅联邦大学教学医院(AEFUTHA)预约孕妇中孕期亲密伴侣暴力(IPV)的发生率、产后抑郁症的发病率以及亲密伴侣暴力、分娩结果和产后抑郁症之间的关系:研究设计:这是一项前瞻性队列研究:研究地点:尼日利亚埃邦伊州阿巴卡利基亚历克斯-埃克乌梅联邦大学教学医院的产前门诊、产前病房、分娩病房、产后门诊和五岁以下儿童门诊:在妊娠 37 周至 41 周期间,招募了 137 名在 AEFUTHA 接受产前护理、符合纳入标准并同意参与研究的预约孕妇,并对她们进行了亲密伴侣暴力和抑郁症筛查。有抑郁症的孕妇将被转介接受治疗,而符合纳入标准的孕妇将被跟踪至分娩,并记录分娩结果。此外,在产后六周还对她们进行了产后抑郁症筛查。数据经过整理、制表,然后使用社会科学统计软件包(SPSS)软件(25 版,美国芝加哥二区)进行统计分析。数字变量包括受试者的年龄、胎次和胎龄,以平均值、中位数、频率和标准差(Mean ± S.D)表示;分类变量包括职业、教育水平、社会阶层和家庭类型,以数字和百分比表示。对于分类变量,采用卡方检验(X2)和相对风险进行组间比较;如果卡方检验(X2)不合适,则采用费雪精确检验。二元回归分析用于确定亲密伴侣暴力与产后抑郁之间的关系。P值˂0.05被认为具有统计学意义:137 名受访女性中有 72 人遭受过亲密伴侣暴力,亲密伴侣暴力的发生率为 52.6%。在这项研究中,亲密伴侣暴力的主要风险因素是教育水平低、社会阶层低、一夫多妻制和失业。产后抑郁症的总体发病率为 29.93%,而遭受亲密伴侣暴力的妇女的发病率为 56.94%。遭受情感暴力和辱骂的妇女产后抑郁症发病率增加了五倍。性暴力和身体暴力并不是产后抑郁症的重要风险因素:结论:从研究中可以看出,亲密伴侣间的暴力行为很常见。结论:从研究中可以看出,亲密伴侣暴力很常见,是产后抑郁症的一个重要风险因素。受到情感和言语虐待的妇女更容易患产后抑郁症。对孕妇进行亲密关系暴力筛查可识别高危人群,并采取适当的干预措施。
{"title":"Profiling intimate partner violence in booked pregnant women at Alex Ekwueme Federal University Teaching Hospital Abakaliki and associated puerperal depressive sequelae: a prospective cohort study.","authors":"Amuchechukwu V Nwafor, Odidika Ugochukwu J Umeora, Arinze C Ikeotuonye, Bobby C Iwe, Justus N Eze, Leonard O Ajah, Christian C Anikwe, Chidi O U Esike, Francis C Okoroafor, Okey Mbanefo, Uchenna N Nwaedu","doi":"10.1186/s12884-024-06869-2","DOIUrl":"10.1186/s12884-024-06869-2","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Intimate partner violence (IPV) in pregnancy is a physical, sexual, psychological or economic harm by a current or former partner or spouse on a pregnant woman. It is a global public health problem that is common but underreported. Women are at increased risk of psychiatric illness in pregnancy and after delivery with the risk of major depressive disorder being highest during the postpartum period. Intimate partner violence in pregnancy may worsen this problem.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Objectives: &lt;/strong&gt;The objectives of the study were to determine the prevalence of intimate partner violence (IPV) in pregnancy, incidence of postpartum depression and the relationship between intimate partner violence, delivery outcomes and postpartum depression among booked pregnant women at Alex Ekwueme Federal University Teaching Hospital Abakaliki, Ebonyi state, Nigeria (AEFUTHA).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Study design: &lt;/strong&gt;This study was a prospective cohort study.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Setting: &lt;/strong&gt;The antenatal clinic, antenatal ward, labour ward, postpartum clinic and under five clinic of Alex Ekwueme Federal University Teaching Hospital Abakaliki, Ebonyi state, Nigeria were used for the study.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Method: &lt;/strong&gt;One hundred and thirty-seven booked pregnant women that received antenatal care at AEFUTHA who met the inclusion criteria and consented to the study, were recruited from 37 weeks to 41 weeks gestation and screened for intimate partner violence and depression. Those with depression were referred for treatment while those that met the inclusion criteria were followed up to delivery and the delivery outcomes documented. They were also followed up to six weeks postpartum when they were screened for postpartum depression. Data were collated, tabulated and then statistically analysed using Statistical Package for Social Science (SPSS) software (version 25, Chicago II, USA). Numerical variables including participant's age, parity and gestational age were presented as mean, median, frequencies and standard deviation (Mean ± S.D), while categorical variables including occupation, level of education, social class and family type were presented as numbers and percentages. Chi-square test (X&lt;sup&gt;2&lt;/sup&gt;) and relative risk was used for comparison between groups for categorical variables while Fisher's exact test was used when Chi-square test (X&lt;sup&gt;2&lt;/sup&gt;) was not suitable. Binary regression analysis was used to determine the relationship between intimate partner violence and postpartum depression. A P value of ˂0.05 is considered statistically significant.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The prevalence of intimate partner violence was 52.6%, as 72 out of the 137 women recruited endured intimate partner violence. The major risk factors for intimate partner violence in the study were low level of education, low social class, polygamy and unemployment. The general incidence of postpartum depression was 29.93% while the incidence among w","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11468848/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142399291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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