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COVID-19 pandemic, pregnancy care, perinatal outcomes in Eastern Myanmar and North-Western Thailand: a retrospective marginalised population cohort. 缅甸东部和泰国西北部的 COVID-19 大流行、孕期保健和围产期结果:边缘化人群队列回顾。
IF 2.8 2区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2024-10-02 DOI: 10.1186/s12884-024-06841-0
Taco Jan Prins, Wanitda Watthanaworawit, Mary Ellen Gilder, Nay Win Tun, Aung Myat Min, May Phoo Naing, Chanapat Pateekhum, Woranit Thitiphatsaranan, Suradet Thinraow, Francois Nosten, Marcus J Rijken, Michele van Vugt, Chaisiri Angkurawaranon, Rose McGready

Background: The COVID-19 pandemic disrupted routine health care and antenatal and birth services globally. The Shoklo Malaria Research Unit (SMRU) based at the Thailand-Myanmar border provides cross border antenatal care (ANC) and birth services to marginalised pregnant women. The border between the countries entered lockdown in March 2020 preventing cross-border access for women from Myanmar to Thailand. SMRU adapted by opening a new clinic during the COVID-19 pandemic in Myanmar. This study explored the impact of the COVID-19 pandemic and response on access to ANC and pregnancy outcomes for marginalised pregnant women in the border regions between Thailand and Myanmar.

Methods: A retrospective review of medical records of all pregnancies delivered or followed at antenatal clinics of the SMRU from 2017 to the end of 2022. Logistic regression was done to compare the odds of maternal and neonatal outcomes between women who delivered pre-COVID (2017-2019) and women who delivered in the COVID-19 pandemic (2020-2022), grouped by reported country of residence: Thailand or Myanmar.

Results: Between 2017 and the end of 2022, there were 13,865 (5,576 resident in Thailand and 8,276 in Myanmar) marginalised pregnant women who followed ANC or gave birth at SMRU clinics. Outcomes of pregnancy were known for 9,748 women with an EGA ≥ 28 weeks. Unknown outcome of pregnancy among women living in Thailand did not increase during the pandemic. However, there was a high (60%) but transient increase in unknown outcome of pregnancy for women with Myanmar residence in March 2020 following border closure and decreasing back to the baseline of 20-30% after establishment of a new clinic. Non-literate women were more likely to have an unknown outcome during the pandemic. There was no statistically significant increase in known stillbirths or maternal deaths during the COVID pandemic in this population but homebirth was over represented in maternal and perinatal mortality.

Conclusion: Decreasing barriers to healthcare for marginalised pregnant women on the Thailand-Myanmar border by establishment of a new clinic was possible in response to sudden border closure during the COVID-19 pandemic and most likely preventing an increase in maternal and perinatal mortality.

背景:COVID-19 大流行扰乱了全球的常规医疗保健以及产前和分娩服务。位于泰缅边境的Shoklo疟疾研究中心(SMRU)为边缘化孕妇提供跨境产前护理(ANC)和分娩服务。2020 年 3 月,两国边境进入封锁状态,缅甸妇女无法跨境进入泰国。在 COVID-19 大流行期间,SMRU 在缅甸开设了一家新诊所。本研究探讨了 COVID-19 大流行和应对措施对泰国和缅甸边境地区边缘化孕妇获得产前保健服务和妊娠结果的影响:方法:对2017年至2022年底在SMRU产前检查诊所分娩或随访的所有孕妇的医疗记录进行回顾性审查。根据报告的居住国分组,对COVID前(2017-2019年)和COVID-19大流行期间(2020-2022年)分娩的产妇和新生儿结局的几率进行了逻辑回归比较:结果:2017年至2022年底,共有13865名(5576名居住在泰国,8276名居住在缅甸)边缘化孕妇在SMRU诊所进行了产前保健或分娩。已知有 9,748 名孕妇的妊娠结果,其 EGA ≥ 28 周。大流行期间,泰国妇女的未知妊娠结果并未增加。然而,在 2020 年 3 月边境关闭后,居住在缅甸的妇女的不明妊娠结果增加了很多(60%),但这是短暂的,在新诊所成立后,这一比例又下降到 20-30% 的基线。大流行期间,不识字的妇女更有可能出现不明妊娠结果。在 COVID 大流行期间,该人群中的已知死产或产妇死亡人数在统计上没有显著增加,但在产妇和围产期死亡率中,在家分娩的比例过高:结论:针对 COVID-19 大流行期间边境突然关闭的情况,通过建立一个新诊所来减少泰缅边境边缘化孕妇获得医疗保健服务的障碍是可行的,而且很可能会防止孕产妇和围产期死亡率的上升。
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引用次数: 0
Cesarean hysterectomy in pregnancies complicated with placenta previa accreta: a retrospective hospital-based study. 前置胎盘并发症孕妇的剖腹产子宫切除术:一项以医院为基础的回顾性研究。
IF 2.8 2区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2024-10-02 DOI: 10.1186/s12884-024-06834-z
Yongchi Zhan, Enfan Lu, Tingting Xu, Guiqiong Huang, Chunyan Deng, Tiantian Chen, Yuxin Ren, Xia Wu, Haiyan Yu, Xiaodong Wang

Background: Placenta previa accreta (PPA) is a severe obstetric condition that can cause massive postpartum hemorrhage and transfusion. Cesarean hysterectomy is necessary in some severe cases of PPA to stop the life-threatening bleeding, but cesarean hysterectomy can be associated with significant surgical blood loss and major complications. The current study is conducted to investigate the potential risk factors of excessive blood loss during cesarean hysterectomy in women with PPA.

Methods: This is a retrospective study including singleton pregnancies after 28 weeks of gestation in women with placenta previa and pathologically confirmed placenta accreta spectrum who received hysterectomy during cesarean sections. A total of 199 women from January 2012 to August 2023 were included in this study and were divided into Group 1 (estimated surgical blood loss (EBL) ≤ 3500 mL, n = 103) and Group 2 (EBL > 3500 mL, n = 96). The primary outcome was defined as an EBL over 3500 mL. Baseline characteristics and surgical outcomes were compared between the two groups. A multivariate logistic regression model was applied to find potential risk factors of the primary outcome.

Results: Massive surgical blood loss was prevalent in our study group, with a median EBL of 3500 mL. The multivariate logistic analysis showed that emergency surgery (OR 2.18, 95% CI 1.08-4.41, p = 0.029), cervical invasion of the placenta (OR 2.70, 95% CI 1.43-5.10, p = 0.002), and intraoperative bladder injury (OR 5.18, 95% CI 2.02-13.28, p = 0.001) were all associated with the primary outcome. Bilateral internal iliac arteries balloon occlusion (OR 0.57, 95% CI 0.34-0.97) and abdominal aortic balloon occlusion (OR 0.33, 95% CI 0.19-0.56) were negatively associated with the primary outcome.

Conclusions: Emergency surgery, cervical invasion of the placenta, and intraoperative bladder injury were potential risk factors for additional EBL during cesarean hysterectomy in women with PPA. Future prospective studies are needed to confirm the effect of intra-arterial balloon occlusion in cesarean hysterectomy of PPA.

背景:前置胎盘(PPA)是一种严重的产科疾病,可导致大量产后出血和输血。在某些严重的 PPA 病例中,必须进行剖宫产子宫切除术,以止住危及生命的出血,但剖宫产子宫切除术可能会导致大量手术失血和重大并发症。本研究旨在调查 PPA 妇女在剖宫产子宫切除术中失血过多的潜在风险因素:这是一项回顾性研究,包括妊娠28周后单胎妊娠的前置胎盘和病理证实的胎盘早剥谱系妇女在剖宫产手术中接受子宫切除术的情况。本研究共纳入了 199 名产妇,时间为 2012 年 1 月至 2023 年 8 月,分为第 1 组(估计手术失血量(EBL)≤ 3500 毫升,n = 103)和第 2 组(EBL > 3500 毫升,n = 96)。主要结果定义为 EBL 超过 3500 毫升。对两组的基线特征和手术结果进行了比较。应用多变量逻辑回归模型寻找主要结果的潜在风险因素:结果:在我们的研究组中,大量手术失血是普遍现象,中位 EBL 为 3500 mL。多变量逻辑分析显示,急诊手术(OR 2.18,95% CI 1.08-4.41,p = 0.029)、宫颈侵犯胎盘(OR 2.70,95% CI 1.43-5.10,p = 0.002)和术中膀胱损伤(OR 5.18,95% CI 2.02-13.28,p = 0.001)均与主要结果相关。双侧髂内动脉球囊闭塞(OR 0.57,95% CI 0.34-0.97)和腹主动脉球囊闭塞(OR 0.33,95% CI 0.19-0.56)与主要结局呈负相关:结论:紧急手术、宫颈侵犯胎盘和术中膀胱损伤是PPA产妇在剖宫产术中发生额外EBL的潜在风险因素。未来还需要进行前瞻性研究,以确认动脉内球囊闭塞术在PPA剖宫产术中的效果。
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引用次数: 0
Explaining maternal antenatal attachment by psychological, clinical and sociodemographic factors: a path analysis study. 用心理、临床和社会人口因素解释产妇产前依恋:一项路径分析研究。
IF 2.8 2区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2024-10-02 DOI: 10.1186/s12884-024-06836-x
Ana Paula Forte Camarneiro, Magda Sofia Roberto, João Manuel Rosado de Miranda Justo

Background: Antenatal attachment is a fundamental concept relative to human transition to parenthood and may be influenced by several factors. The aim of this study is to find the best model to explain maternal antenatal attachment based on the interaction among sociodemographic, clinical, and psychological variables.

Methods: Pregnant women (N = 407) were interviewed during the second trimester of pregnancy while waiting for medical consultations. A sociodemographic, obstetric, and psychometric protocol was used.

Statistical analyses: path analysis.

Independent variables: psychopathological symptomatology, depression, anxiety, stress, occupational stress, attitudes about pregnancy and motherhood, coping styles, marital satisfaction, sociodemographic, and clinical variables.

Dependent variables: maternal antenatal attachment in its several dimensions; quality of attachment (QA), intensity of preoccupation (IP), and global attachment (GA).

Results: Depression, anxiety, attitudes, and marital satisfaction explained 37% of maternal antenatal QA. Age, depression, anxiety, attitudes, and marital satisfaction explained 26% of maternal antenatal IP. Age, depression, anxiety, attitudes, and marital satisfaction explained 34% of the statistical variance of maternal antenatal GA.

Conclusions: Factors like emotional states (depression and anxiety), attitudes towards pregnancy and motherhood, marital satisfaction, and a sociodemographic variable (age) contribute significantly for the explanation of maternal antenatal attachment.

背景:产前依恋是人类向为人父母过渡的一个基本概念,可能受到多种因素的影响。本研究的目的是根据社会人口、临床和心理变量之间的相互作用,找到解释产妇产前依恋的最佳模型:方法:在妊娠后三个月的候诊期间,对孕妇(N = 407)进行访谈。统计分析:路径分析。自变量:精神病理症状、抑郁、焦虑、压力、职业压力、对怀孕和做母亲的态度、应对方式、婚姻满意度、社会人口学和临床变量。因变量:产妇产前依恋的几个维度;依恋质量(QA)、先入为主强度(IP)和整体依恋(GA):抑郁、焦虑、态度和婚姻满意度解释了产妇产前依恋质量的 37%。年龄、抑郁、焦虑、态度和婚姻满意度解释了产妇产前 IP 的 26%。年龄、抑郁、焦虑、态度和婚姻满意度可解释 34% 的产妇产前 GA 统计变异:结论:情绪状态(抑郁和焦虑)、对怀孕和做母亲的态度、婚姻满意度和社会人口变量(年龄)等因素对解释产妇产前依恋有重要作用。
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引用次数: 0
Association between serum branched chain amino acids, mammalian target of rapamycin levels and the risk of gestational diabetes mellitus: a 1:1 matched case control study. 血清支链氨基酸、哺乳动物雷帕霉素靶标水平与妊娠糖尿病风险之间的关系:一项 1:1 匹配病例对照研究。
IF 2.8 2区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2024-10-02 DOI: 10.1186/s12884-024-06815-2
Lingling Cui, Zhiqian Li, Xinxin Liu, Zhonglei Li, Jiaxin Li, Yingying Guo, Huijun Zhou, Xiaoli Yang, Zhengya Zhang, Yuting Gao, Lina Ren, Linlin Hua

Background: To investigate the association between serum branched chain amino acids (BCAAs), mammalian target of rapamycin (mTOR) levels and the risk of gestational diabetes mellitus (GDM) in pregnant women.

Methods: 1:1 matched case-control study was conducted including 66 GDM patients and 66 matched healthy pregnant women (± 3 years) in 2019, in China. Fasting bloods of pregnant women were collected in pregnancy at 24 ~ 28 weeks gestation. And the serum levels of valine (Val), leucine (Leu), isoleucine (Ile) and mTOR were determined. Conditional logistic regressions models were used to estimate the associations of BCAAs and mTOR concentrations with the risk of GDM.

Results: Concentrations of serum Val and mTOR in cases were significantly higher than that in controls (P < 0.05). After adjusted for the confounded factors, both the second tertile and the third tertile of mTOR increased the risk of GDM (OR = 11.771, 95%CI: 3.949-35.083; OR = 4.869 95%CI: 1.742-13.611, respectively) compared to the first tertile of mTOR. However, the second tertile of serum Val (OR = 0.377, 95%CI:0.149-0.954) and the second tertile of serum Leu (OR = 0.322, 95%CI: 0.129-0.811) decreased the risk of GDM compared to the first tertile of serum Val and Leu, respectively. The restricted cubic spline indicated a significant nonlinear association between the serum levels of mTOR and the risk of GDM (P values for non-linearity = 0.0058).

Conclusion: We confirmed the association of higher mTOR with the increased risk of GDM in pregnant women. Pregnant women who were in the certain range level of Val and Leu were at lower risk of GDM. Our findings provided epidemiological evidence for the relation of serum BCAAs and mTOR with risk of GDM.

背景:目的:探讨孕妇血清支链氨基酸(BCAAs)、哺乳动物雷帕霉素靶标(mTOR)水平与妊娠期糖尿病(GDM)风险之间的关系。方法:于2019年在中国进行了1:1匹配病例对照研究,包括66名GDM患者和66名匹配的健康孕妇(±3岁)。在妊娠 24~28 周时采集孕妇空腹血。测定血清中缬氨酸(Val)、亮氨酸(Leu)、异亮氨酸(Ile)和 mTOR 的水平。采用条件逻辑回归模型估计 BCAAs 和 mTOR 浓度与 GDM 风险的关系:结果:病例血清中 Val 和 mTOR 的浓度明显高于对照组(P<0.05):我们证实了孕妇的 mTOR 含量越高,患 GDM 的风险越高。缬氨酸和亮氨酸水平在一定范围内的孕妇患 GDM 的风险较低。我们的研究结果为血清中 BCAAs 和 mTOR 与 GDM 风险的关系提供了流行病学证据。
{"title":"Association between serum branched chain amino acids, mammalian target of rapamycin levels and the risk of gestational diabetes mellitus: a 1:1 matched case control study.","authors":"Lingling Cui, Zhiqian Li, Xinxin Liu, Zhonglei Li, Jiaxin Li, Yingying Guo, Huijun Zhou, Xiaoli Yang, Zhengya Zhang, Yuting Gao, Lina Ren, Linlin Hua","doi":"10.1186/s12884-024-06815-2","DOIUrl":"10.1186/s12884-024-06815-2","url":null,"abstract":"<p><strong>Background: </strong>To investigate the association between serum branched chain amino acids (BCAAs), mammalian target of rapamycin (mTOR) levels and the risk of gestational diabetes mellitus (GDM) in pregnant women.</p><p><strong>Methods: </strong>1:1 matched case-control study was conducted including 66 GDM patients and 66 matched healthy pregnant women (± 3 years) in 2019, in China. Fasting bloods of pregnant women were collected in pregnancy at 24 ~ 28 weeks gestation. And the serum levels of valine (Val), leucine (Leu), isoleucine (Ile) and mTOR were determined. Conditional logistic regressions models were used to estimate the associations of BCAAs and mTOR concentrations with the risk of GDM.</p><p><strong>Results: </strong>Concentrations of serum Val and mTOR in cases were significantly higher than that in controls (P < 0.05). After adjusted for the confounded factors, both the second tertile and the third tertile of mTOR increased the risk of GDM (OR = 11.771, 95%CI: 3.949-35.083; OR = 4.869 95%CI: 1.742-13.611, respectively) compared to the first tertile of mTOR. However, the second tertile of serum Val (OR = 0.377, 95%CI:0.149-0.954) and the second tertile of serum Leu (OR = 0.322, 95%CI: 0.129-0.811) decreased the risk of GDM compared to the first tertile of serum Val and Leu, respectively. The restricted cubic spline indicated a significant nonlinear association between the serum levels of mTOR and the risk of GDM (P values for non-linearity = 0.0058).</p><p><strong>Conclusion: </strong>We confirmed the association of higher mTOR with the increased risk of GDM in pregnant women. Pregnant women who were in the certain range level of Val and Leu were at lower risk of GDM. Our findings provided epidemiological evidence for the relation of serum BCAAs and mTOR with risk of GDM.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11446021/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142364323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Investigating different dimensions of women's childbirth experiences and its predictors among postnatal women: findings from a cross sectional study. 调查产后妇女分娩经历的不同层面及其预测因素:一项横断面研究的结果。
IF 2.8 2区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2024-10-02 DOI: 10.1186/s12884-024-06840-1
Monirolsadate Hosseini Tabaghdehi, Setareh Haqshenas, Roya Nikbakht, Fatemeh Hamidi, Zohreh Shahhosseini

Background and aims: Childbirth experience is an event in a woman's life with short- and long-term effects on her physical and mental health. This study aimed to investigate different dimensions of women's childbirth experiences and its predictors.

Methods: This cross-sectional study was conducted on 430 postnatal women with vaginal delivery in 2021 in Northern Iran. Data were collected using the Iranian women's childbirth experience questionnaire (IWCEQ) and demographic and pregnancy-related characteristics questionnaire. Principal component analysis using Amos 24 and backward multiple linear regression using SPSS 22 were employed to analyze the data.

Results: The mean score of childbirth experiences was 48.48 ± 19.09% out of 100 (95% CI: 46.68-50.28). The Principal Component Analysis revealed that the preparation (β = 0.84), positive perception (β = 0.78), and fear dimensions (β= -0.72) were the most important dimensions of women's childbirth experiences. Moreover, education (B = -7.14, p = 0.001), spouse's education (B = 7.40, p = 0.001), history of previous childbirth (B = 4.88, p = 0.001), obstetric problems of previous childbirth (B = - 7.73, p = 0.038), mother's preferred type of delivery (B = 9.34, p = 0.001), the simultaneous delivery of another baby in the delivery room (B = -3.39, p = 0.017), and birth weight (B = -5.79, p = 0.005) explained 40% of the variance of the childbirth experience score.

Conclusion: Childbirth experience is a unique experience that influenced by positive and negative issues. More studies to identify related factors to dimensions of childbirth experience may have some insights for developing national and local- level health policies and clinical protocols.

背景和目的:分娩经历是妇女生命中的一件大事,对其身心健康有着短期和长期的影响。本研究旨在调查妇女分娩经历的不同维度及其预测因素:这项横断面研究的对象是伊朗北部 2021 年经阴道分娩的 430 名产后妇女。使用伊朗妇女分娩经历问卷(IWCEQ)和人口学及妊娠相关特征问卷收集数据。数据分析采用 Amos 24 主成分分析法和 SPSS 22 反向多元线性回归法:分娩经历的平均得分是 48.48 ± 19.09%(满分 100 分)(95% CI:46.68-50.28)。主成分分析显示,准备(β=0.84)、积极认知(β=0.78)和恐惧(β=-0.72)是妇女分娩体验最重要的维度。此外,教育程度(B=-7.14,P=0.001)、配偶教育程度(B=7.40,P=0.001)、既往分娩史(B=4.88,P=0.001)、既往分娩产科问题(B=-7.73,P=0.038)、母亲偏好的分娩方式(B = 9.34,p = 0.001)、产房同时分娩另一个婴儿(B = -3.39,p = 0.017)和出生体重(B = -5.79,p = 0.005)解释了分娩体验得分变异的 40%:结论:分娩体验是一种受积极和消极问题影响的独特体验。结论:分娩体验是一种独特的体验,受到积极和消极问题的影响。开展更多研究以确定与分娩体验相关的因素,可能会对制定国家和地方一级的卫生政策和临床方案有所启发。
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引用次数: 0
What are the mechanisms of effect of group antenatal care? A systematic realist review and synthesis of the literature. 集体产前护理的效果机制是什么?现实主义系统回顾与文献综述。
IF 2.8 2区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2024-10-01 DOI: 10.1186/s12884-024-06792-6
Anita Mehay, Giordana Da Motta, Louise Hunter, Juliet Rayment, Meg Wiggins, Penny Haora, Christine McCourt, Angela Harden

Background: There is growing interest in the benefits of group models of antenatal care. Although clinical reviews exist, there have been few reviews that focus on the mechanisms of effect of this model.

Methods: We conducted a realist review using a systematic approach incorporating all data types (including non-research and audiovisual media), with synthesis along Context-Intervention-Mechanism-Outcome (CIMO) configurations.

Results: A wide range of sources were identified, yielding 100 relevant sources in total (89 written and 11 audiovisual). Overall, there was no clear pattern of 'what works for whom, in what circumstances' although some studies have identified clinical benefits for those with more vulnerability or who are typically underserved by standard care. Findings revealed six interlinking mechanisms, including: social support, peer learning, active participation in health, health education and satisfaction or engagement with care. A further, relatively under-developed theory related to impact on professional practice. An overarching mechanism of empowerment featured across most studies but there was variation in how this was collectively or individually conceptualised and applied.

Conclusions: Mechanisms of effect are amplified in contexts where inequalities in access and delivery of care exist, but poor reporting of populations and contexts limited fuller exploration. We recommend future studies provide detailed descriptions of the population groups involved and that they give full consideration to theoretical underpinnings and contextual factors.

Registration: The protocol for this realist review was registered in the International Prospective Register of Systematic Reviews (PROSPERO CRD42016036768).

背景:人们越来越关注产前护理小组模式的益处。虽然有临床综述,但很少有综述关注这种模式的作用机制:方法:我们采用系统的方法对所有数据类型(包括非研究和视听媒体)进行了现实主义综述,并按照 "背景-干预-机制-结果"(CIMO)配置进行了综合分析:结果:共确定了 100 个相关来源(89 个书面来源和 11 个视听来源)。总体而言,尽管一些研究发现了对那些更易受伤害的人或通常得不到标准护理服务的人的临床益处,但 "在什么情况下对什么人有效 "并没有明确的模式。研究结果显示了六种相互关联的机制,包括:社会支持、同伴学习、积极参与健康、健康教育以及对护理的满意度或参与度。另一个相对欠发达的理论与对专业实践的影响有关。大多数研究都强调了增强能力的总体机制,但在如何集体或单独地将其概念化和应用方面存在差异:结论:在获取和提供医疗服务方面存在不平等的情况下,影响机制会被放大,但对人群和环境的报告不足限制了更全面的探索。我们建议未来的研究应详细描述所涉及的人群,并充分考虑理论基础和背景因素:本现实主义综述的方案已在国际系统综述前瞻性注册中心注册(PROSPERO CRD42016036768)。
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引用次数: 0
Association of SARS-CoV-2 infection during late pregnancy with maternal and neonatal outcomes. 孕晚期感染 SARS-CoV-2 与孕产妇和新生儿预后的关系。
IF 2.8 2区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2024-10-01 DOI: 10.1186/s12884-024-06816-1
Ting Du, Yawen Zhang, Xueli Zha, Qin Huang

Background: Limited data on the impact of the coronavirus disease 2019 (COVID-19) during pregnancy on newborn outcomes are available. This study aimed to characterize and compare the clinical outcomes of newborns from women with and without the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection during late pregnancy.

Method: This was a retrospective cohort study of women who were either infected or not infected with the SARS-CoV-2 virus during late pregnancy. The neonatal complications associated with COVID-19-positive pregnant women were investigated and analyzed.

Results: Among 2063 pregnant women over 28 weeks of gestation, 1.2%, 3.3%, and 18.7% of patients with multiple pregnancies, abnormal fetal positions, and lack of maternal or neonatal follow-up data, respectively, were excluded. Patients who were COVID-19-negative (60.6%) and -positive (16.2%) remained for further analysis. SARS-CoV-2 infection was significantly associated with higher SARS-CoV-2 infection rates in newborns (0% vs. 1.49%, P < 0.01) and longer duration of hospital stay (6.39 ± 2.2 vs. 4.92 ± 1.6, P < 0.01). However, comparing neonatal complications, including Apgar score, preterm birth, low birth weight, cesarean section rate, newborn hearing, neonatal congenital heart defects, and height and weight compliance rate of 6-month-old children, between non-infected and infected participants did not reach statistical significance.

Conclusion: SARS-CoV-2 infection in late pregnancy has no significant impact on neonatal outcomes. After six months of follow-up of the neonates, we observed that SARS-CoV-2 infection in the third trimester of pregnancy did not affect their growth and development. Hopefully, these findings will guide management strategies and clinical practice.

背景:有关妊娠期冠状病毒病2019(COVID-19)对新生儿预后影响的数据有限。本研究旨在描述和比较妊娠晚期感染和未感染严重急性呼吸系统综合征冠状病毒-2(SARS-CoV-2)的妇女所生新生儿的临床结局:这是一项回顾性队列研究,研究对象是妊娠晚期感染或未感染 SARS-CoV-2 病毒的妇女。调查并分析了 COVID-19 阳性孕妇的新生儿并发症:结果:在 2063 名妊娠超过 28 周的孕妇中,分别有 1.2%、3.3% 和 18.7%的多胎妊娠、胎位异常和缺乏产妇或新生儿随访数据的患者被排除在外。COVID-19阴性(60.6%)和阳性(16.2%)的患者仍在进一步分析中。新生儿 SARS-CoV-2 感染率较高与 SARS-CoV-2 感染明显相关(0% 对 1.49%,P 结论:新生儿 SARS-CoV-2 感染率较高与 SARS-CoV-2 感染明显相关):孕晚期感染 SARS-CoV-2 对新生儿的预后没有明显影响。经过对新生儿六个月的跟踪观察,我们发现在妊娠晚期感染 SARS-CoV-2 并不会影响新生儿的生长发育。希望这些发现能为管理策略和临床实践提供指导。
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引用次数: 0
Effect of blastomere cell number on ART outcome of fresh single day 3 embryo transfer. 囊胚细胞数对第 3 天新鲜单胚胎移植的 ART 结果的影响。
IF 2.8 2区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2024-10-01 DOI: 10.1186/s12884-024-06825-0
Ling Tang, Chenyun Sun, Yuxia He, Haiyu Hou, Yaqi Shang, Li Li, Yuling Mao, Lei Li

Purpose: Explore the effect of blastomere cell number on ART outcome of fresh embryo transfer on day 3.

Methods: Retrospective analysis of 540 fresh single day 3 embryo transfer cycles at the Reproductive Center of the Third Affiliated Hospital of Guangzhou Medical University from January 1, 2018 to October 31, 2022. Patients were divided into 5-6 cell group (n = 55), 7-9 cell group (n = 457), and ≥ 10 cell group(n = 28) based on the number of blastomeres. Single factor analysis of variance and Pearson's chi square test were used to compare the basic data, cycle information, pregnancy outcome and neonatal outcome. Univariate logistic regression was used to correct for confounding factors and analyze the influencing factors of pregnancy outcome.

Results: The positive HCG rate were 20%, 43%, 25% for the 5-6-cell, 7-9 cell and ≥ 10 cell groups respectively, with statistically significant differences (P < 0.001). The clinical pregnancy rate was 18%, 42%,21%, respectively (P < 0.001). The live birth rates were 13%, 34%,21% with P-value less than 0.05 which is statistically significant. In order to exclude the influence of confounding factors, multivariable logistic regression analysis was performed, and the outcomes were consistent with previous findings. There were no significant differences found in neonatal outcome between groups (P > 0.05).

Conclusion: The results suggested that intermediate cleaving embryos (7-9 cell) still presents the highest clinical potential. Fast and slow cleaving embryos are not conducive to the ART outcome.

目的:探讨囊胚细胞数对第3天新鲜胚胎移植ART结果的影响:回顾性分析2018年1月1日至2022年10月31日广州医科大学附属第三医院生殖中心540例第3天新鲜单胚胎移植周期。根据胚泡数量将患者分为5-6细胞组(n = 55)、7-9细胞组(n = 457)和≥10细胞组(n = 28)。采用单因素方差分析和皮尔逊卡方检验比较基本数据、周期信息、妊娠结局和新生儿结局。采用单变量逻辑回归校正混杂因素,分析妊娠结局的影响因素:结果:5-6细胞组、7-9细胞组和≥10细胞组的HCG阳性率分别为20%、43%和25%,差异有统计学意义(P 0.05):结果表明,中速分裂胚胎(7-9 细胞)仍具有最大的临床潜力。结论:结果表明,中度裂解胚胎(7-9 个细胞)仍具有最高的临床潜力,快速和慢速裂解胚胎不利于 ART 的结果。
{"title":"Effect of blastomere cell number on ART outcome of fresh single day 3 embryo transfer.","authors":"Ling Tang, Chenyun Sun, Yuxia He, Haiyu Hou, Yaqi Shang, Li Li, Yuling Mao, Lei Li","doi":"10.1186/s12884-024-06825-0","DOIUrl":"10.1186/s12884-024-06825-0","url":null,"abstract":"<p><strong>Purpose: </strong>Explore the effect of blastomere cell number on ART outcome of fresh embryo transfer on day 3.</p><p><strong>Methods: </strong>Retrospective analysis of 540 fresh single day 3 embryo transfer cycles at the Reproductive Center of the Third Affiliated Hospital of Guangzhou Medical University from January 1, 2018 to October 31, 2022. Patients were divided into 5-6 cell group (n = 55), 7-9 cell group (n = 457), and ≥ 10 cell group(n = 28) based on the number of blastomeres. Single factor analysis of variance and Pearson's chi square test were used to compare the basic data, cycle information, pregnancy outcome and neonatal outcome. Univariate logistic regression was used to correct for confounding factors and analyze the influencing factors of pregnancy outcome.</p><p><strong>Results: </strong>The positive HCG rate were 20%, 43%, 25% for the 5-6-cell, 7-9 cell and ≥ 10 cell groups respectively, with statistically significant differences (P < 0.001). The clinical pregnancy rate was 18%, 42%,21%, respectively (P < 0.001). The live birth rates were 13%, 34%,21% with P-value less than 0.05 which is statistically significant. In order to exclude the influence of confounding factors, multivariable logistic regression analysis was performed, and the outcomes were consistent with previous findings. There were no significant differences found in neonatal outcome between groups (P > 0.05).</p><p><strong>Conclusion: </strong>The results suggested that intermediate cleaving embryos (7-9 cell) still presents the highest clinical potential. Fast and slow cleaving embryos are not conducive to the ART outcome.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11446145/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142361038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Can maternal inflammatory and nutritional status, evaluated by the hemoglobin, albumin, lymphocyte, and platelet (HALP) score and the prognostic nutritional index (PNI) in the first trimester, predict late-onset fetal growth restriction? 通过妊娠头三个月的血红蛋白、白蛋白、淋巴细胞和血小板(HALP)评分和预后营养指数(PNI)评估母体炎症和营养状况,能否预测晚期胎儿生长受限?
IF 2.8 2区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2024-10-01 DOI: 10.1186/s12884-024-06811-6
Zeynep Seyhanli, Burak Bayraktar, Gulsan Karabay, Ahmet Arif Filiz, Mevlut Bucak, Recep Taha Agaoglu, Can Ozan Ulusoy, Tugba Kolomuc, Kadriye Yakut Yucel, Zehra Vural Yilmaz

Objective: The aim of this study was to evaluate the potential of immunonutritional markers, specifically the hemoglobin, albumin, lymphocyte, and platelet (HALP) score and the prognostic nutritional index (PNI), in predicting late-onset fetal growth restriction (LO-FGR) during the first trimester.

Materials and methods: This retrospective study was conducted at a tertiary care center between October 2022 and August 2023. The study included a total of 213 singleton pregnancies, with 99 women in the LO-FGR group and 114 in the healthy control group, matched by maternal age and gestational age at delivery. All blood samples were collected between 11 and 14 weeks of gestation (during the first-trimester screening test). We analyzed first-trimester laboratory parameters, specifically focusing on hemoglobin levels, white blood cells (WBCs), lymphocytes, platelets, and albumin levels. Afterwards, we calculated the HALP score and PNI, and then compared the values of both groups.

Results: Both HALP score (3.58 ± 1.31 vs. 4.19 ± 1.8, p = 0.012) and PNI (36.75 ± 2.9 vs. 39.37 ± 3.96, p < 0.001) were significantly lower in the FGR group than in the control group. The HALP score cut-off value of < 3.43 in predicting FGR had a sensitivity of 62.3% and specificity of 54.5% (AUC = 0.600, 95% CI: 0.528-0.672, p = 0.012). The PNI cut-off value of < 37.9 in predicting FGR had a sensitivity of 65.8% and specificity of 62.9% (AUC = 0.707, 95% CI: 0.632-0.778, p < 0.001). While the HALP score was not a significant predictor of composite adverse neonatal outcomes in the FGR group, PNI showed a cut-off value of < 37.7 with a sensitivity of 60.9% and specificity of 59.7% (AUC = 0.657, 95% CI: 0.581-0.733, p < 0.001).

Conclusion: The HALP score and PNI are valuable prognostic tools for predicting the risk of FGR in the first trimester. Low PNI values are also associated with composite adverse neonatal outcomes in pregnancies complicated by FGR.

研究目的本研究旨在评估免疫营养标记物,特别是血红蛋白、白蛋白、淋巴细胞和血小板(HALP)评分和预后营养指数(PNI)在预测妊娠头三个月晚期胎儿生长受限(LO-FGR)方面的潜力:这项回顾性研究于2022年10月至2023年8月在一家三级医疗中心进行。该研究共纳入 213 例单胎妊娠,其中 LO-FGR 组 99 例,健康对照组 114 例。所有血样都是在妊娠 11 至 14 周(第一胎筛查试验期间)采集的。我们分析了第一胎的实验室参数,特别是血红蛋白水平、白细胞(WBC)、淋巴细胞、血小板和白蛋白水平。随后,我们计算了 HALP 评分和 PNI,然后比较了两组的数值:结果:HALP 评分(3.58±1.31 vs. 4.19±1.8,P = 0.012)和 PNI(36.75±2.9 vs. 39.37±3.96,P 结论:HALP 评分和 PNI 均高于 HALP 评分:HALP 评分和 PNI 是预测前三个月胎儿畸形风险的重要预后工具。低 PNI 值还与 FGR 并发妊娠的新生儿综合不良结局相关。
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引用次数: 0
Early oral feeding within two hours for parturients compared with delayed oral feeding after cesarean section: a systematic review and meta-analysis. 剖宫产术后两小时内对产妇进行早期口服喂养与延迟口服喂养的比较:系统综述和荟萃分析。
IF 2.8 2区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2024-10-01 DOI: 10.1186/s12884-024-06838-9
Dongxu Chen, Bingchen Lang, Lan Wu, Shengping Zhou, Shouming Chen

Background: It is recommended that postpartum women undergo early oral feeding (EOF) after cesarean section (CS). However, the optimal early time for oral feeding after CS is unclear. We performed a meta-analysis to assess whether EOF within two hours is superior to delayed oral feeding (DOF) after CS.

Methods: The PubMed, Embase, Cochrane Library, and Google Scholar databases were searched from inception to February 2024 for randomized controlled trials comparing EOF versus DOF after CS. Primary outcomes included the time to normal bowel function. The secondary outcomes included postoperative complications, the time to ambulation after surgery, the time to removal of the catheter, the time to start of a regular diet, the length of hospital stay and patient satisfaction.

Results: Data from 8 studies involving a total of 2572 women were obtained. EOF within two hours was significantly associated with shorter durations of return bowel movement (WMD, - 2.41, 95% CI, - 3.80-- 1.02; p < 0.001; I2 = 96%), passage flatus after surgery (WMD, - 3.55, 95% CI, - 6.36-- 0.75; p = 0.01; I2 = 98%), ambulation after surgery (WMD, - 0.96, 95% CI, - 1.80-- 0.13; p = 0.02; I2 = 53%), removal of catheters (WMD, - 15.18, 95% CI, - 25.61-- 4.74; p = 0.004; I2 = 100%) and starting a regular diet (WMD, - 7.03, 95% CI, - 13.13-- 0.92; p = 0.02; I2 = 99%) compared with DOF. EOF was not related to increased vomiting (RR, 1.08; 95% CI, 0.74-1.57; p = 0.69; I2 = 0%), nausea (RR, 1.21; 95% CI, 0.83-1.77; p = 0.33; I2 = 37%), abdominal distension (RR, 0.76; 95% CI, 0.31-1.89; p = 0.55; I2 = 54%) or ileus (RR, 0.91; 95% CI, 0.40-2.06; p = 0.81; I2 = 12%).

Conclusions: This meta-analysis provides evidence that EOF within two hours after CS has comparable safety with DOF, and can accelerate the recovery time for normal bowel function.

Trial registration: INPLASY202320055.

背景:建议产后妇女在剖宫产术(CS)后尽早进行口腔喂养(EOF)。然而,剖腹产后口服喂养的最佳早期时间尚不明确。我们进行了一项荟萃分析,以评估在剖宫产术后两小时内进行早期口服喂养是否优于延迟口服喂养(DOF):方法:我们在 PubMed、Embase、Cochrane Library 和 Google Scholar 数据库中搜索了从开始到 2024 年 2 月的 CS 后 EOF 与 DOF 比较的随机对照试验。主要结果包括肠道功能恢复正常的时间。次要结果包括术后并发症、术后行走时间、拔除导管时间、开始正常饮食时间、住院时间和患者满意度:结果:共获得了 8 项研究的数据,涉及 2572 名妇女。两小时内EOF与排便时间缩短(WMD,- 2.41,95% CI,- 3.80-- 1.02;P 2 = 96%)、术后排便(WMD,- 3.55,95% CI,- 6.36-- 0.75;P = 0.01;I2 = 98%)、术后行走(WMD,- 0.96,95% CI,- 1.80-- 0.13;P = 0.02;I2 = 53%)、移除导管(WMD,- 15.18,95% CI,- 25.61-- 4.74;P = 0.004;I2 = 100%)和开始规律饮食(WMD,- 7.03,95% CI,- 13.13-- 0.92;P = 0.02;I2 = 99%)与 DOF 相比。EOF与呕吐增加(RR,1.08;95% CI,0.74-1.57;P = 0.69;I2 = 0%)、恶心(RR,1.21;95% CI,0.83-1.77;P = 0.33;I2 = 37%)、腹胀(RR,0.76;95% CI,0.31-1.89;P = 0.55;I2 = 54%)或回肠炎(RR,0.91;95% CI,0.40-2.06;P = 0.81;I2 = 12%).结论:这项荟萃分析提供了证据,证明在 CS 后两小时内进行 EOF 与 DOF 的安全性相当,并能加快肠道正常功能的恢复时间:Inplasy202320055.
{"title":"Early oral feeding within two hours for parturients compared with delayed oral feeding after cesarean section: a systematic review and meta-analysis.","authors":"Dongxu Chen, Bingchen Lang, Lan Wu, Shengping Zhou, Shouming Chen","doi":"10.1186/s12884-024-06838-9","DOIUrl":"10.1186/s12884-024-06838-9","url":null,"abstract":"<p><strong>Background: </strong>It is recommended that postpartum women undergo early oral feeding (EOF) after cesarean section (CS). However, the optimal early time for oral feeding after CS is unclear. We performed a meta-analysis to assess whether EOF within two hours is superior to delayed oral feeding (DOF) after CS.</p><p><strong>Methods: </strong>The PubMed, Embase, Cochrane Library, and Google Scholar databases were searched from inception to February 2024 for randomized controlled trials comparing EOF versus DOF after CS. Primary outcomes included the time to normal bowel function. The secondary outcomes included postoperative complications, the time to ambulation after surgery, the time to removal of the catheter, the time to start of a regular diet, the length of hospital stay and patient satisfaction.</p><p><strong>Results: </strong>Data from 8 studies involving a total of 2572 women were obtained. EOF within two hours was significantly associated with shorter durations of return bowel movement (WMD, - 2.41, 95% CI, - 3.80-- 1.02; p < 0.001; I<sup>2</sup> = 96%), passage flatus after surgery (WMD, - 3.55, 95% CI, - 6.36-- 0.75; p = 0.01; I<sup>2</sup> = 98%), ambulation after surgery (WMD, - 0.96, 95% CI, - 1.80-- 0.13; p = 0.02; I<sup>2</sup> = 53%), removal of catheters (WMD, - 15.18, 95% CI, - 25.61-- 4.74; p = 0.004; I<sup>2</sup> = 100%) and starting a regular diet (WMD, - 7.03, 95% CI, - 13.13-- 0.92; p = 0.02; I<sup>2</sup> = 99%) compared with DOF. EOF was not related to increased vomiting (RR, 1.08; 95% CI, 0.74-1.57; p = 0.69; I<sup>2</sup> = 0%), nausea (RR, 1.21; 95% CI, 0.83-1.77; p = 0.33; I<sup>2</sup> = 37%), abdominal distension (RR, 0.76; 95% CI, 0.31-1.89; p = 0.55; I<sup>2</sup> = 54%) or ileus (RR, 0.91; 95% CI, 0.40-2.06; p = 0.81; I<sup>2</sup> = 12%).</p><p><strong>Conclusions: </strong>This meta-analysis provides evidence that EOF within two hours after CS has comparable safety with DOF, and can accelerate the recovery time for normal bowel function.</p><p><strong>Trial registration: </strong>INPLASY202320055.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11443750/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142361037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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