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What is the Level of Awareness of Novel Coronavirus (SARS-CoV-2) Among Greek Students in the Days of School Reopening? 在学校重新开学的日子里,希腊学生对新型冠状病毒(SARS-CoV-2)的认识程度如何?
Pub Date : 2021-12-06 DOI: 10.26717/bjstr.2021.40.006473
Dimitrios Lamprinos
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引用次数: 1
RNAi and CRISPR: Promising Tool for Gene Silencing RNAi和CRISPR:有前途的基因沉默工具
Pub Date : 2021-12-06 DOI: 10.26717/bjstr.2021.40.006444
P. Sen
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引用次数: 0
"Protection and Utilization of Medicinal Biological Resources to Address Cross-Border Risk Challenges" “保护和利用药用生物资源应对跨境风险挑战”
Pub Date : 2021-12-06 DOI: 10.26717/bjstr.2021.40.006445
Ming Fu Li
Citation: Yun Song, Ming Fu Li, Jin Xu. Protection and Utilization of Medicinal Biological Resources to Address Cross-Border Risk Challenges. Biomed J Sci & Tech Res 40(3)-2021. BJSTR. MS.ID.006445. Biological resources are the basis for human survival and development and have a direct bearing on our wellbeing. Humans must respect nature and follow its ways. Medicinal biological resources are important strategic biological resources, especially at the risk of loss and abuse. The cross-border trade based on economic interests has led to the over exploitation and abuse of biological species resources. A new pattern of biological resources conservation has largely taken shape, with improvements to the legal system, supervision mechanisms and governing capacity for eco-conservation, marking the beginning of a new era for biological resources conservation and utilization.
引用本文:宋云,李明福,徐进。保护和利用药用生物资源应对跨境风险挑战。中国生物医学工程学报,30(3):391 - 391。BJSTR。MS.ID.006445。生物资源是人类生存和发展的基础,直接关系到我们的福祉。人类必须尊重自然,遵循自然的方式。药用生物资源是重要的战略性生物资源,尤其存在流失和滥用的风险。基于经济利益的跨境贸易导致了对生物物种资源的过度开发和滥用。生物资源保护新格局初步形成,生态保护法律体系、监督机制和治理能力不断完善,生物资源保护利用进入新时代。
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引用次数: 1
"RP-HPLC Method Development and Validation for Estimation of Naftidrofuryl Oxalate Using Box- Behnken Design" Box- Behnken设计反相高效液相色谱法测定草酸萘甲呋喃酯的方法建立及验证
Pub Date : 2021-12-06 DOI: 10.26717/bjstr.2021.40.006447
K. R Gupta
A simple, rapid, precise, sensitive, economical, robust and QbD based RP -HPLC method has been developed for Naftidrofuryl oxalate and validated as per ICH guidelines. The response surface methodology employed with a 3-factor, 3- level Box-Behnken statistical design and used to facilitate method development and optimization. The response surface methodology and multiple response optimizations utilizing a polynomial equation were used to select suitable mobile phase combination. The independent variables studied were the Organic phase (X 1 ), Aqueous phase(X2) and (X 3 ) and the responses was Retention time (Y 1 ), Resolution (Y 2 ) and Tailing factor (Y 3 ). Chromatographic separation was achieved on Zodiac C18 column (100mm×4.6, 3µm),using optimized mobile phase Acetonitrile and pH-7 Tetrabutyl-ammonium buffer solution (90:10), at 282nm. The flow rate and injection volume were 1.0 mL-1 min and 20 µL, respectively. Analysis of variance (ANOVA) confirmed that the three factors were significant. The method was validated for linearity, system suitability, recovery (accuracy), precision, robustness, ruggedness, limit of quantitation (LOD) and detection (LOQ) as per the ICH guidelines. The precision, ruggedness and robustness values were also within the prescribed limits. Calibrations curves were linear (r2= 0.997) at the concentration range of 10 to 50μg/mL. LOD and LOQ values were 12.914µg/mL and 39.132µg/mL respectively. The proposed method was successfully developed by applying QBD based concept and proposed method can be used for routine analysis of Naftidrofuryl oxalate in quality control laboratories.
建立了一种简便、快速、精确、灵敏、经济、稳健、基于QbD的草酸萘替呋喃酯反相高效液相色谱分析方法,并根据ICH指南进行了验证。响应面法采用3因素、3层次Box-Behnken统计设计,用于促进方法开发和优化。采用响应面法和多项式方程的多重响应优化选择合适的移动相组合。自变量为有机相(x1)、水相(X2)和水相(x3),响应变量为保留时间(Y 1)、分辨率(Y 2)和尾化因子(Y 3)。色谱柱为Zodiac C18 (100mm×4.6, 3µm),采用优化流动相乙腈和pH-7四丁基铵缓冲溶液(90:10),在282nm处进行分离。流速1.0 mL-1 min,进样量20µL。方差分析(ANOVA)证实这三个因素具有显著性。根据ICH指南验证了该方法的线性度、系统适用性、回收率(准确度)、精密度、鲁棒性、坚固性、定量限(LOD)和检出限(LOQ)。精密度、坚固性和鲁棒性均在规定范围内。在10 ~ 50μg/mL浓度范围内,校准曲线呈线性(r2= 0.997)。定量限和定量限分别为12.914µg/mL和39.132µg/mL。应用基于QBD的概念成功建立了该方法,该方法可用于质量控制实验室中草酸萘甲呋喃酯的常规分析。
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引用次数: 0
"Pontocerebellar Hypoplasia Caused by De Novo Mutation in PAFAH1B1 (LIS1) Gene" PAFAH1B1 (LIS1)基因从头突变引起桥小脑发育不全
Pub Date : 2021-12-06 DOI: 10.26717/bjstr.2021.40.006443
Katiane Sayão Souza Cabral
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引用次数: 0
"Oral PEY Treatment Induces Hair Regrowth and Improves Hair Quality in Patients with Alopecia" 口服PEY治疗可促进脱发患者头发再生并改善发质
Pub Date : 2021-12-03 DOI: 10.26717/bjstr.2021.40.006441
Joan Cunill
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引用次数: 0
"Combined Mobile Unit for Supercritical CO2-Extraction of Bio-Active Components" 超临界co2萃取生物活性成分组合式移动装置
Pub Date : 2021-12-03 DOI: 10.26717/bjstr.2021.40.006438
D. Starokadomsky
A review and assessment of methods for the extraction of active biocomponents from plant raw materials is presented. The overview contains a tables to facilitate the initial perception of this topic. Examples of stationary and mobile installations developed in the world are described. The prospects of the Super-critical CO 2 -extraction method, as the most effective for the extraction of valuable biomedical components, have been analyzed. The schemes and samples of the used CO 2 -extractors are shown. The technical diagrams and appearance of the author’s experimental supercritical CO 2 extractor were presented. A detailed description of an new-generation of experimental mobile installationwere done, its complete set and the possibilities of supercritical CO 2 -extraction for processing plant raw materials are given. New engineering and technical solutions in the operation of a mechanical system were demonstrated. There includes an improved construction of a high gas-pressure throttle valve installed in storage tanks, and innovations in the system for loading-unloading raw materials using removable nozzles. The operating parameters of the functional elements and their resource are indicated. As a result of successful working, the templates of obtained extracts were presented.
对植物原料中活性生物成分的提取方法进行了综述和评价。概述中包含了一些表格,以方便对这个主题的初步理解。介绍了世界上开发的固定和移动装置的实例。分析了超临界co2萃取法作为提取有价值生物医学成分最有效的方法的发展前景。给出了常用co2萃取器的方案和样品。介绍了实验用超临界co2萃取器的技术原理图和外观。对新一代实验移动装置进行了详细的介绍,并给出了装置的成套情况和超临界co2萃取处理加工厂原料的可能性。演示了机械系统运行中的新工程和技术解决方案。其中包括安装在储罐中的高压节流阀的改进结构,以及使用可移动喷嘴装卸原材料的系统的创新。指出了各功能元件的运行参数及其资源。工作成功的结果,得到了萃取物的模板。
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引用次数: 0
"Evaluation of an Active Butanol Fraction Effects of Blighia Unijugata (Sapindaceae) Leaves on Some Biochemical Blood Parameters in Male Wistar Rats" “单叶灯盏叶活性丁醇组分对雄性Wistar大鼠血液生化指标影响的评价”
Pub Date : 2021-12-03 DOI: 10.26717/bjstr.2021.40.006440
N’dia Kouadio Frédéric
Evaluation of an Active Butanol Fraction Effects of Blighia Unijugata (Sapindaceae) Leaves on Some Biochemical Blood Parameters in Male Wistar Rats . Biomed J Sci Blighia many therapeutic indications in d’Ivoire. This study evaluated the effects of oral administration of an active butanol fraction of Blighia unijugata for 28 days on some biochemical blood parameters of male rats. The active butanolic fraction of Blighia unijugata
Unijugata (Sapindaceae)叶片活性丁醇组分对Wistar雄性大鼠血液生化指标影响的研究。生物医学J . Sci . Blighia在科特迪瓦有许多治疗指征。本研究评价了单叶螺旋体活性丁醇组分口服28 d对雄性大鼠血液生化指标的影响。刺叶螺旋藻的活性丁醇组分
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引用次数: 0
"Kaizen Concept or Methodology to Improve the Performance in the Health Care and Patient Safety Business and its Advantages" 改善医疗保健和患者安全业务绩效的概念或方法及其优势
Pub Date : 2021-12-03 DOI: 10.26717/bjstr.2021.40.006439
Ahsan Ali Siddiqui
or Methodology Performance the business advantages. Methods: methodology Results: way to implement the KAIZEN tool in the organization and to show the 10 major benefits of KAIZEN analysis tool. Conclusion:
或方法论表现业务优势。结果:在组织中实施改善工具的方法,并显示改善分析工具的10个主要好处。结论:
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引用次数: 1
"Outcome of Fetoscopic Laser Coagulation in 61 Pregnancies with Twin-Twin Transfusion Syndrome in Viet Nam" 越南61例双胎输血综合征胎儿镜激光凝固治疗的结果
Pub Date : 2021-12-03 DOI: 10.26717/bjstr.2021.40.006442
Dinh Thi Hien Le
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引用次数: 0
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