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"Pathology of Epizootic-Infectious Diseases of Fishes in Aquaculture" 水产养殖鱼类动物传染病病理学
Pub Date : 2021-11-24 DOI: 10.26717/bjstr.2021.40.006413
Firew Admasu
This article was developed for seminar presentation of PhD study in Aquaculture and fishery management. Background: to a quality, overcrowding and to quarantine. Management practices in than treatment. Objectives: Methods: conclusion:
这篇文章是为水产养殖和渔业管理博士研究的研讨会报告而编写的。背景:要有质量,要拥挤,要隔离。管理实践比治疗。目的:方法:结论:
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引用次数: 0
"The Impact of Sequencing Genomes on the Understanding of the Origin of Life on Earth" “基因组测序对了解地球生命起源的影响”
Pub Date : 2021-11-24 DOI: 10.26717/bjstr.2021.40.006416
A. H. Khan
This abstract describes the scientific basis of the origin of life on Earth. Life has never been on Earth like as it is today. It has evolved over millions of years from a single cell microbe to a trillion-cell human being. The history of the evolution of life on Earth is trapped as fossils in the geological formation of rocks trapped in the Earth. The lowest level of the three and a half billion-year-old rocks contains the fossil of the simplest life forms. As we moved up to study geological formation of the younger and younger layers of rocks, we observe accumulation of mutations over millions of years, resulting in the increase complexity of fossil records. We have recently learned a technique to extract DNA from the fossils. Using modern technique developed during genome sequencing, our analysis of the DNA from the fossil revealed the structures of ancient life forms. The sequencing of human genome has provided us with a genetic toolkit which contains molecular scissors (enzymes such as restriction enzyme, like EcoR1, DNA polymerase, DNA ligase etc.), to cut, paste, copy, and sequence a gene. This abstract also describes how we can move a gene from one species to another to benefit the bourgeoning population of the world by providing new food, new fuel, and new medicine to treat every disease known to mankind.
这篇摘要描述了地球上生命起源的科学依据。地球上的生命从来没有像今天这样。它经历了数百万年的进化,从一个单细胞微生物到一个拥有数万亿个细胞的人类。地球上生命的进化史以化石的形式被困在岩石的地质构造中,被困在地球上。35亿年前的岩石的最底层包含着最简单的生命形式的化石。当我们进一步研究越来越年轻的岩层的地质形成时,我们观察到数百万年来突变的积累,导致化石记录的复杂性增加。我们最近学会了一种从化石中提取DNA的技术。利用基因组测序过程中开发的现代技术,我们对化石DNA的分析揭示了古代生命形式的结构。人类基因组测序为我们提供了一个包含分子剪刀(酶如限制性内切酶,如EcoR1、DNA聚合酶、DNA连接酶等)的基因工具箱,可以剪切、粘贴、复制和测序一个基因。这篇摘要还描述了我们如何将一个基因从一个物种转移到另一个物种,通过提供新的食物、新的燃料和新的药物来治疗人类已知的每一种疾病,从而使世界上不断增长的人口受益。
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引用次数: 3
Nutritional and Healthy Benefits of Fruits 水果的营养和健康益处
Pub Date : 2021-11-24 DOI: 10.26717/bjstr.2021.40.006412
W. Abobatta
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引用次数: 3
"Anthelmintic Activity in Vitro of Ceratotheca Sesamoides Endl and Striga Hermonthica (Delile) Benth Aqueous Extracts on Haemonchus Contortus Adult Worms" 山麻角毛苔和赤刺草底水提取物体外对弯血螨成虫的驱虫活性
Pub Date : 2021-11-24 DOI: 10.26717/bjstr.2021.40.006414
A. Dicko
Citation: Amadou Dicko, Almamy Konate, Arnaud S.R. Tapsoba, Kisito Tindano, Moumouni Sanou, et al., Anthelmintic Activity in Vitro of Ceratotheca Sesamoides Endl and Striga Hermonthica (Delile) Benth Aqueous Extracts on Haemonchus Contortus Adult Worms. Biomed J Sci & Tech Res 40(2)-2021. BJSTR. MS.ID.006414. In order to contribute for alternatives solutions to the chemical fight against NGIs, we carried out in vitro anthelmintic activity test of C. sesamoïdes, and of S. hermonthica aqueous extracts on adult worms of H. contortus. Three concentrations of each extract has be done; 100mg / ml, 50mg / ml and 25mg / ml. A negative control (PBS 1X) and a positive control levamisole at 2.5 mg / ml were constituted. The test was performed in three replicates with three replicas for each concentration per replicate. Adult worms were contacted with each concentration and then incubated in petri dishes (60X15cm) at 27 °C for 20 hours. The results showed a mortality rate of 79.86% at the concentration of 100mg / ml of C. sesamoids and 22.13% at the same concentration of the aqueous extract of S. hermonthica after 20 hours. Statistical analysis shows high significance P (<0,05). The LC (50) obtained were 78.74mg / ml and 212.13mg / ml respectively for C. sesamoides and S. hermonthica
引用本文:Amadou Dicko, Almamy Konate, Arnaud S.R. Tapsoba, Kisito Tindano, Moumouni Sanou等,Ceratotheca Sesamoides Endl和Striga Hermonthica (Delile) Benth水提物对Haemonchus Contortus成虫的体外驱虫活性。中国生物医学工程学报,30(2):391 - 391。BJSTR。MS.ID.006414。为了提供化学对抗NGIs的替代解决方案,我们进行了C. sesamoïdes和S. hermonthica水提物对H. contortus成虫的体外驱虫活性测试。每种萃取物的浓度都做了三次;分别为100mg / ml、50mg / ml和25mg / ml,阴性对照(PBS 1X)和阳性对照(2.5 mg / ml)。试验分三个重复进行,每个重复每个浓度有三个重复。将不同浓度的成虫接触于60X15cm的培养皿中,27℃孵育20小时。结果表明,100mg / ml的芝麻籽麻水提液处理20 h后,其死亡率为79.86%,相同浓度的芝麻籽麻水提液处理20 h后,其死亡率为22.13%。统计学分析P < 0.05,差异有显著性。得到的LC(50)分别为78.74mg / ml和212.13mg / ml
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引用次数: 0
Zinc and COVID-19 锌与COVID-19
Pub Date : 2021-11-23 DOI: 10.26717/bjstr.2021.40.006411
D. R
Editorial After iron, Zinc is the second most abundant trace metal in the human body. Zinc has a main role in various cellular functions such as maintenance of immune health. This property of zinc is of great significance in the COVID-19 pandemic. Studies show that Zinc exhibits antiviral activity through inhibition of SARS-CoV RNA polymerase. It also regulates inflammatory response and modulates antiviral and antibacterial immunity. [1,2] Studies show that Zinc produces significant effect on viral infections by variation in viral fusion, replication and translation of viral protein. Trial show that Zinc supplementation in COVID 19 patients decreased airway neutrophil infiltration and TNF-α release by impeding NF-kB-dependent transcription of inflammatory genes. [1,2] According to recent research Zinc can be used as adjunct therapy for viral life-threatening infections such as COVID 19. Zinc repletion produces anti-viral effects, moderates the cytokine storm, helps in early recovery, as it causes renewed nucleic acid and protein synthesis. [3] Zinc is an essential nutrient that has antiviral properties. Further research is essential to understand its therapeutic potential against life-threatening viral infections.
继铁之后,锌是人体内含量第二丰富的微量金属。锌在多种细胞功能中起主要作用,如维持免疫健康。锌的这一特性在COVID-19大流行中具有重要意义。研究表明锌通过抑制SARS-CoV RNA聚合酶表现出抗病毒活性。它还能调节炎症反应,调节抗病毒和抗菌免疫。[1,2]研究表明,锌通过改变病毒的融合、复制和病毒蛋白的翻译,对病毒感染产生显著影响。试验表明,补充锌可通过抑制nf - kb依赖性炎症基因的转录,降低COVID - 19患者气道中性粒细胞浸润和TNF-α释放。[1,2]根据最近的研究,锌可以作为病毒性感染(如COVID - 19)的辅助治疗。锌的补充产生抗病毒作用,调节细胞因子风暴,有助于早期恢复,因为它会导致新的核酸和蛋白质合成。[3]锌是一种具有抗病毒特性的必需营养素。进一步的研究对于了解其治疗威胁生命的病毒感染的潜力至关重要。
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引用次数: 1
"Emerging COVID- 19 Coronavirus and its Interaction and Simulation With N-(Glycine) and N-(Alanine) -Para Styrene Sulfonamide as New Drugs and Compare with Sulphadiazine, Sulfacetamide and Sulfathiazole" 新出现的COVID- 19冠状病毒及其与N-(甘氨酸)和N-(丙氨酸)-对苯乙烯磺酰胺作为新药的相互作用和模拟,并与磺胺嘧啶、磺胺乙酰胺和磺胺噻唑的比较
Pub Date : 2021-11-23 DOI: 10.26717/bjstr.2021.40.006409
E. Mehdipour
Emerging COVID- 19 Coronavirus and its Interaction and Simulation With N-(Glycine) and N-(Alanine) -Para Styrene Sulfonamide as New Drugs and Compare with Sulphadiazine, Sulfacetamide and Sulfathiazole. Biomed A new and modern method for investigation of covid-19 has been reported. In this study, simulation between coronavirus with the synthesized compounds as new drugs such as N-(glycine)-para styrene sulfonamide (GSS) and N-(alanine) - Para-styrene sulfonamide (ASS) was performed and compared with sulphadiazine (SDA), sulfacetamide (SAC), and sulfathiazole (STZ) as common drugs. Molecular docking has recently been used as a tool to gain insight into ligand–receptor interaction and display molecules for the binding affinities against a special receptor. Molecular docking calculations were performed on Auto Dock-Vina software. The 3D crystal structure of employed SARS-CoV spike glycoprotein (7ACD) as Covid-19 and receptor were obtained from Protein Data Bank. The empirical free energy and the Lamarckian Genetic Algorithm was applied for molecular docking 7ACDwith GSS and ASS as anti-infection agents was used for molecular docking simulation. In addition, these interactions were compared with sulphadiazine, sulfacetamide, and sulfathiazole modeling. That is shown biological properties of these new sulfonamides similar to sulphadiazine, sulfacetamide, and sulfathiazole.
新出现的COVID- 19冠状病毒及其与N-(甘氨酸)和N-(丙氨酸)-对苯乙烯磺酰胺作为新药的相互作用和模拟,并与磺胺嘧啶、磺胺乙酰胺和磺胺噻唑的比较。报道了一种新的、现代的covid-19调查方法。本研究模拟了冠状病毒与N-(甘氨酸)-对苯乙烯磺酰胺(GSS)和N-(丙氨酸)-对苯乙烯磺酰胺(ASS)等合成化合物作为新药的关系,并与磺胺嘧啶(SDA)、磺胺乙酰胺(SAC)和磺胺噻唑(STZ)作为常用药物进行了比较。分子对接最近被用作了解配体-受体相互作用和显示分子对特殊受体的结合亲和力的工具。在Auto Dock-Vina软件上进行分子对接计算。利用蛋白数据库获得SARS-CoV刺突糖蛋白(7ACD)作为新冠病毒和受体的三维晶体结构。采用经验自由能和拉马克遗传算法进行分子对接,7acd以GSS和ASS为抗感染剂进行分子对接模拟。此外,将这些相互作用与磺胺嘧啶、磺胺乙酰胺和磺胺噻唑模型进行了比较。结果表明,这些新型磺胺类化合物具有与磺胺嘧啶、磺胺乙酰胺和磺胺噻唑相似的生物学特性。
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引用次数: 0
"The Deadly COVID-19 Being in Pandemic Near Two Years may be Man-Made in Inhumanity" “即将在近两年内流行的致命COVID-19可能是不人道的人为行为”
Pub Date : 2021-11-23 DOI: 10.26717/bjstr.2021.40.006410
X. Han–You
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引用次数: 0
Heart Substructures Delineation in Lung SBRT: Central and Ultra-Central Lesions 肺SBRT的心脏亚结构描绘:中心和超中心病变
Pub Date : 2021-11-23 DOI: 10.26717/bjstr.2021.40.006408
Rodríguez Plá M
et al., Heart Substructures Delineation in Lung SBRT: Central and Ul-tra-Central Lesions. Biomed J Sci & Tech Res 40(1)-2021. BJSTR. MS.ID.006408.
肺SBRT的心脏亚结构描绘:中央和超中心病变。中国生物医学工程学报,30(1):444 - 444。BJSTR。MS.ID.006408。
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引用次数: 1
"The Global Challenge of Colistin Resistance – Recent Evidence from Romania and Elsewhere" 《粘菌素耐药性的全球挑战——来自罗马尼亚和其他地方的最新证据》
Pub Date : 2021-11-22 DOI: 10.26717/bjstr.2021.40.006404
E. Nastase
The Global Challenge of Colistin Resistance – Recent Evidence from Romania and Elsewhere. Biomed J Sci & Tech Res The increasing resistance of Gram-negative bacilli to a wide range of antibiotics has driven a return to colistin as the last resort in the treatment of severe infections. Given the stakes of colistin efficiency at both the individual level and generally, the manifestation and mechanisms of resistance to polymyxin E (also known as colistin) are now subject to careful monitoring and research. Recent findings from different parts of the world including Romania are reviewed and discussed in the light of ensuing challenges.
粘菌素耐药性的全球挑战——来自罗马尼亚和其他地方的最新证据。革兰氏阴性杆菌对多种抗生素的耐药性日益增强,促使粘菌素重新成为治疗严重感染的最后手段。鉴于粘菌素在个体水平和总体水平上的有效性,对多粘菌素E(也称为粘菌素)的耐药性的表现和机制现在受到仔细的监测和研究。根据随之而来的挑战,审查和讨论了包括罗马尼亚在内的世界不同地区最近的调查结果。
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引用次数: 0
Esophageal Perforation Surgical Management 食管穿孔手术治疗
Pub Date : 2021-11-22 DOI: 10.26717/bjstr.2021.40.006405
Burkan Nasr Rashed Shaif
the back or left shoulder with signs of peritoneal irritation. Early diagnosis are important step in patients with Esophageal perforation, The diagnostic study of choice in any patient suspected of having an esophageal perforation is a contrast radiograph of the esophagus. A water soluble contrast esophagogram followed by barium, if necessary, is diagnostic in 90% of patients. CT scan of the chest and upper abdomen with oral contrast is also used with more frequency are more sensitive to localize site of perforation ,area of necrosis or fluid collection in mediastinal or pleural cavity. The plain chest radiograph less sensitive may appear normal early after esophageal perforation but however present pneumomediastinum, subcutaneous emphysema, pleural effusion, and hydropneumothorax, these findings in chest x. Ray highly suggestive of esophageal perforation [2,3]. Treatment should also be stepwise with consideration given to: patients clinical status and stability, Time since perforation, Location/size of the perforation, the extent of tissue necrosis and degree of contamination, the presence of underlying esophageal disease or disorder (Barrett’s,malignancy,achalasia ..ets). If esophageal perforation is suspected, immediate treatment should begin with cessation of all oral intake, intravenous fluid ABSTRACT The esophageal perforation remains a potentially devastating condition. Rapid diagnosis and therapy provide the best chance for survival; however, delay in diagnosis is common, resulting in substantial morbidity and mortality. This article discusses the diagnosis and Surgical Management for this potentially lethal Gastrointestinal condition.
背部或左肩有腹膜刺激迹象。早期诊断是食管穿孔患者的重要一步,任何怀疑有食管穿孔的患者的诊断研究选择是食道造影。如有必要,可在90%的患者中进行水溶性造影剂食道造影并行钡餐检查。胸部及上腹部CT加口腔造影剂扫描频率也较高,对纵隔腔或胸膜腔穿孔部位、坏死区域或积液的定位更为敏感。食管穿孔后早期,胸片不太敏感的平片可能表现正常,但出现纵隔气肿、皮下肺气肿、胸腔积液和气胸积液,这些胸部x线表现高度提示食管穿孔[2,3]。治疗也应逐步考虑:患者的临床状态和稳定性,穿孔的时间,穿孔的位置/大小,组织坏死的程度和污染的程度,是否存在潜在的食管疾病或紊乱(巴雷特病,恶性肿瘤,贲门失弛缓症等)。如果怀疑有食道穿孔,应立即开始治疗,停止一切口服和静脉输液。快速诊断和治疗提供了最好的生存机会;然而,诊断延误是常见的,导致大量的发病率和死亡率。本文讨论了这种潜在致命性胃肠道疾病的诊断和手术治疗。
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引用次数: 0
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Biomedical Journal of Scientific & Technical Research
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