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Next Generation DNA Sequencing Technologies 下一代DNA测序技术
Pub Date : 2021-01-01 DOI: 10.35248/0974-8369.21.13.E102
Kelly Sarton
Copyright: 2021 © Sarton K. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Next generation sequencing (NGS), massively parallel or deep sequencing are related terms that describe a DNA sequencing technology which has revolutionised genomic research. In contrast, the previous Sanger sequencing technology, used to decipher the human genome, required over a decade to deliver the final draft. Although in genome research NGS has mostly superseded conventional Sanger sequencing, it has not yet translated into routine clinical practice. The aim of this article is to review the potential applications of NGS in paediatrics.
版权所有:2021©Sarton K.这是一篇根据知识共享署名许可条款发布的开放获取文章,该许可允许在任何媒体上不受限制地使用,分发和复制,前提是原始作品被适当引用。下一代测序(NGS),大规模平行测序或深度测序是描述一种DNA测序技术的相关术语,它已经彻底改变了基因组研究。相比之下,之前用于破译人类基因组的桑格测序技术需要十多年的时间才能完成最终草案。尽管在基因组研究中,NGS在很大程度上取代了传统的Sanger测序,但它尚未转化为常规临床实践。本文的目的是回顾NGS在儿科的潜在应用。
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引用次数: 0
Low Back Pain: Its Mechanisms, Symptoms and Diagnosis 腰痛:机制、症状和诊断
Pub Date : 2021-01-01 DOI: 10.35248/0974-8369.21.13.E112
N. Jawad
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引用次数: 0
Medicine and Its Uses 医药及其用途
Pub Date : 2021-01-01 DOI: 10.35248/0974-8369.21.13.E116
C. Chou
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引用次数: 0
Cancer Biology And Its Effects 癌症生物学及其影响
Pub Date : 2021-01-01 DOI: 10.35248/0974-8369.21.13.434
C. Chou
Copyright: 2021 © Chou CP. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Cancer frameworks science includes the application of frameworks science approaches to cancer investigate, in arrange to think about the malady as a complex versatile framework with rising properties at different natural scales. Cancer frameworks science speaks to the application of frameworks science approaches to the investigation of how the intracellular systems of typical cells are annoyed amid carcinogenesis to create viable prescient models that can help researchers and clinicians within the validations of unused treatments and drugs. Tumors are characterized by genomic and epigenetic flimsiness that modifies the capacities of numerous distinctive atoms and systems in a single cell as well as modifying the intelligent with the nearby environment. Cancer frameworks science approaches, in this manner, are based on the utilize of computational and scientific strategies to disentangle the complexity in tumorigenesis as well as cancer heterogeneity. Cancer frameworks science includes concrete applications.
版权所有:2021©Chou CP.这是一篇根据知识共享署名许可条款发布的开放获取文章,该许可允许在任何媒介上不受限制地使用,分发和复制,前提是正确引用原始作品。癌症框架科学包括框架科学方法在癌症研究中的应用,以便将疾病视为一个复杂的多功能框架,在不同的自然尺度上具有不断上升的特性。癌症框架科学涉及框架科学方法的应用,研究典型细胞的细胞内系统如何在癌变过程中受到干扰,以创建可行的先见之明模型,帮助研究人员和临床医生验证未使用的治疗方法和药物。肿瘤的特点是基因组和表观遗传的脆弱性,这种脆弱性改变了单个细胞中许多不同的原子和系统的能力,也改变了附近环境的智能。以这种方式,癌症框架科学方法是基于利用计算和科学策略来解开肿瘤发生的复杂性以及癌症的异质性。癌症框架科学包括具体的应用。
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引用次数: 0
Structures of Cell Biology 细胞生物学结构
Pub Date : 2021-01-01 DOI: 10.35248/0974-8369.21.13.E115
M. J. Equbal
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引用次数: 0
Types of Pathology 病理类型
Pub Date : 2021-01-01 DOI: 10.35248/0974-8369.21.13.E118
Jun-Ping Liu
Copyright: 2021 © Liu JP. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Pathology is the consider of the causes and impacts of malady or harm. The word pathology moreover alludes to the ponder of malady in common, consolidating a wide extend of science inquire about areas and therapeutic hones. In any case, when utilized within the setting of cutting edge restorative treatment, the term is frequently utilized in a more limit design to allude to forms and tests which drop inside the modern therapeutic field of "common pathology", an region which incorporates a number of unmistakable but inter-related therapeutic specialties that analyze illness, generally through examination of tissue, cell, and body liquid tests. Informally, "a pathology" may too allude to the anticipated or real movement of particular illnesses (as within the articulation "the numerous diverse shapes of cancer have differing pathologies", in which case a more legitimate choice of word would be "pathophysiologies") and the fasten pathy is now and then utilized to demonstrate a state of illness in cases of both physical affliction (as in cardiomyopathy) and psychics.
版权所有:2021©Liu JP。这是一篇根据知识共享署名许可协议发布的开放获取文章,该协议允许在任何媒体上不受限制地使用、分发和复制,前提是正确引用原始作品。病理学是对疾病或伤害的原因和影响的考虑。病理学这个词还暗示了对疾病的共同思考,巩固了广泛的科学研究领域和治疗领域。在任何情况下,当在尖端恢复性治疗的背景下使用时,该术语经常在更有限的设计中使用,以暗指属于现代治疗领域“共同病理学”的形式和测试,该领域包含许多明确无误但相互关联的治疗专业,通常通过检查组织,细胞和体液测试来分析疾病。非正式地,“病理学”也可能暗指特定疾病的预期或实际运动(如在发音中,“许多不同形状的癌症有不同的病理学”,在这种情况下,更合理的词选择是“病理生理学”),而病理有时被用来证明身体痛苦(如心肌病)和精神疾病的疾病状态。
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引用次数: 2
Excessive Drinking of Alcohol and its Effects 过量饮酒及其影响
Pub Date : 2021-01-01 DOI: 10.35248/0974-8369.21.13.438
K. Dyke
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引用次数: 0
Market Review and Growth Analysis on Generic Medicine 仿制药市场回顾与增长分析
Pub Date : 2021-01-01 DOI: 10.35248/0974-8369.21.13.E113
S. Goyal
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引用次数: 0
Biological Molecules and Morphogenesis 生物分子与形态发生
Pub Date : 2021-01-01 DOI: 10.35248/0974-8369.21.13.E124
Jun-Ping Liu
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引用次数: 0
Medication Adherence: Assess Compliance and Associated Factors among Hypertensive Patients 药物依从性:评估高血压患者的依从性及相关因素
Pub Date : 2020-08-10 DOI: 10.23937/2474-3690/1510048
Ramawat Yashawant, K. Nitesh, P. Shatrughan, K. Vijay, S. Ankur
Background: Health care decision-makers require more information on differences in compliance rates associated with antihypertensive drugs and the implications of these differences for health care utilization and costs. This community- based prospective study was conduct to Assess hypertensive patients’ compliance with their prescribed regimen. Method: This is a cross-sectional community- based prospective study. Four hundred hypertensive patients were selected from OPD of tertiary care center hospital Delhi. Data were collect through a structured questionnaire and then analyzed by SPSS. Results: The finding of this study shows that the majority of the selected patients belonged to the old age group. Females were slightly more than males. . A total of 56% of patients were fully compliant with their antihypertensive treatments. Two factors were identified to be independently associated with compliance: gender (P=0.51), Age (P=1.10).educational status (P=0.028) were found to have significant effects on compliance Conclusion: Patients’ compliance need to improve for that we need pharmacists adhere to their new role that requires proper dispensing practices. There is persistence and improvement in compliance to antihypertensive medications after an education of the patients about hypertension and its complications. Education about hypertension knowledge should be strengthened for patients Patient compliance need to improve for that we need to make a guideline for pharmacists adhere to their new role that requires proper dispensing practices.
背景:卫生保健决策者需要更多关于降压药依从性差异的信息,以及这些差异对卫生保健利用和成本的影响。这项基于社区的前瞻性研究旨在评估高血压患者对其处方方案的依从性。方法:这是一项基于社区的横断面前瞻性研究。从德里三级护理中心医院的门诊部挑选了400名高血压患者。通过结构化问卷收集数据,然后用SPSS进行分析。结果:本研究的发现表明,大多数选定的患者属于老年组。雌性略多于雄性。共有56%的患者完全接受了降压治疗。两个因素被确定为与依从性独立相关:性别(P=0.51)、年龄(P=1.10)。教育状况(P=0.028)对依从性有显著影响结论:患者的依从性需要提高,因此我们需要药剂师坚持他们的新角色,这需要适当的配药实践。在对患者进行有关高血压及其并发症的教育后,抗高血压药物的依从性得到了持续和改善。应加强对患者的高血压知识教育患者依从性需要提高,为此,我们需要制定一项指导方针,让药剂师坚持他们的新角色,这需要正确的配药实践。
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引用次数: 2
期刊
Biology and medicine (Aligarh)
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