Pub Date : 2020-01-01DOI: 10.35248/0974-8369.20.12.464
Jordan T. Carter, John J. Pisquiy, Michael M. Polmear, R. Khalifa, Gilberto A. Gonzalez
Iatrogenic causes of nerve injuries make up to 17.4% of all traumatic peripheral nerve injuries. Despite significant medicolegal implications, there is no accepted classification system. In this article we propose a new classification system for iatrogenic peripheral nerve injuries: 1) Injury to the nerve when the nerve was not the target of the treatment; 2) Injury to the nerve when the nerve was targeted for intervention but not repair; 3) Injury to the nerve when the nerve was targeted for harvest or repair of another nerve.
{"title":"A New Classification of Iatrogenic Peripheral Nerve Injuries","authors":"Jordan T. Carter, John J. Pisquiy, Michael M. Polmear, R. Khalifa, Gilberto A. Gonzalez","doi":"10.35248/0974-8369.20.12.464","DOIUrl":"https://doi.org/10.35248/0974-8369.20.12.464","url":null,"abstract":"Iatrogenic causes of nerve injuries make up to 17.4% of all traumatic peripheral nerve injuries. Despite significant medicolegal implications, there is no accepted classification system. In this article we propose a new classification system for iatrogenic peripheral nerve injuries: 1) Injury to the nerve when the nerve was not the target of the treatment; 2) Injury to the nerve when the nerve was targeted for intervention but not repair; 3) Injury to the nerve when the nerve was targeted for harvest or repair of another nerve.","PeriodicalId":90454,"journal":{"name":"Biology and medicine (Aligarh)","volume":"12 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69962063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.35248/0974-8369.20.12.466
S. Jafri, N. Jawad, N. Ahmed, Nausheen Saifullah, I. Siddiqui
Background: We frequently come across patients whose debility had worsened even after completing pulmonary tuberculosis treatment. Data on the aftermath of tuberculosis from all over the world is insufficient. Methods: A cross-sectional study was done retrospectively at Jinnah Postgraduate Medical Centre, Karachi, Pakistan. All the patients above 15 years of age who were correctly diagnosed and treated for pulmonary TB were taken from the last one year ’ s hospital files. Pulmonary artery systolic pressure was measured through trans-thoracic echocardiography. Results: 88.9% patients had pulmonary hypertension of varying degrees; most of which fell in the mild and moderate category (44% and 42% respectively). Mean pulmonary artery pressure was 58.83 ± 18.45 mmHg. The estimated mean ± SD time of hospital-survival without PH was 16 ± 1.9 days whereas with PH it was 23.6 ± 1.9 days. Conclusion: Since a substantial number of patients develop pulmonary hypertension after pulmonary tuberculosis, clinicians should thus maintain a high degree of suspicion with regard to pulmonary hypertension when following them.
{"title":"Post Pulmonary Tuberculosis: The Right Heart Story","authors":"S. Jafri, N. Jawad, N. Ahmed, Nausheen Saifullah, I. Siddiqui","doi":"10.35248/0974-8369.20.12.466","DOIUrl":"https://doi.org/10.35248/0974-8369.20.12.466","url":null,"abstract":"Background: We frequently come across patients whose debility had worsened even after completing pulmonary tuberculosis treatment. Data on the aftermath of tuberculosis from all over the world is insufficient. Methods: A cross-sectional study was done retrospectively at Jinnah Postgraduate Medical Centre, Karachi, Pakistan. All the patients above 15 years of age who were correctly diagnosed and treated for pulmonary TB were taken from the last one year ’ s hospital files. Pulmonary artery systolic pressure was measured through trans-thoracic echocardiography. Results: 88.9% patients had pulmonary hypertension of varying degrees; most of which fell in the mild and moderate category (44% and 42% respectively). Mean pulmonary artery pressure was 58.83 ± 18.45 mmHg. The estimated mean ± SD time of hospital-survival without PH was 16 ± 1.9 days whereas with PH it was 23.6 ± 1.9 days. Conclusion: Since a substantial number of patients develop pulmonary hypertension after pulmonary tuberculosis, clinicians should thus maintain a high degree of suspicion with regard to pulmonary hypertension when following them.","PeriodicalId":90454,"journal":{"name":"Biology and medicine (Aligarh)","volume":"12 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69962466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.35248/0974-8369.20.12.465
A. Everts, Devaraj M. Navaratnam, S. Navaratnam, D. Navaratnam
Introduction: We evaluated COVID19 epidemic trajectories of different countries in terms of relative trajectory steepness and anticipated epidemic duration, in other words “flatness of the curve”. Methods: We used open-domain data on COVID-19 reported cases and deaths per country per day. A subset of 47 countries was analysed. Data were fitted with an analytical model following Gompertz equation. Uncertainty pertaining to the model forecasts was also quantified. To relate differences in epidemic trajectories of different countries to the mitigation approach taken by governments of those countries, we made use of the COVID-19 Government Response Stringency Index developed and published by Oxford University and Blavatnik School. Results: Acceptable quality fits were obtained for all the countries with R2 mostly in excess of 0.98. Uncertainty on the final Cases and/or Deaths count is typically a factor of two early in the epidemic but this quickly reduces as the epidemic progresses. Uncertainty on Epidemic Duration also reduces but less fast. Statistics on key parameters like Epidemic Duration, Epidemic Peak and Final Mortality Rate were obtained and then cross-correlated with the rigor of government measures as recorded in the Stringency Score. Most significantly, we find a clear trend of decreasing Peak Epidemic height (and to a less extent, shorter Epidemic Duration) with increased Government Stringency at the epidemic onset. We also find that Final Mortality Rate decreases with increased Stringency of Government Testing and Contact-Tracing. Conclusions: Whilst COVID-19 epidemic trajectories for most countries are similar, some countries do have flatter and less severe trajectories than others. Our analysis suggests that mitigation measures taken by a government at the very initial stage of a COVID-19 outbreak might significantly impact severity and to a less extent duration of the epidemic.
{"title":"Analysing Covid-19 Epidemic Trajectories: are Countries Flattening the Curve?","authors":"A. Everts, Devaraj M. Navaratnam, S. Navaratnam, D. Navaratnam","doi":"10.35248/0974-8369.20.12.465","DOIUrl":"https://doi.org/10.35248/0974-8369.20.12.465","url":null,"abstract":"Introduction: We evaluated COVID19 epidemic trajectories of different countries in terms of relative trajectory steepness and anticipated epidemic duration, in other words “flatness of the curve”. Methods: We used open-domain data on COVID-19 reported cases and deaths per country per day. A subset of 47 countries was analysed. Data were fitted with an analytical model following Gompertz equation. Uncertainty pertaining to the model forecasts was also quantified. To relate differences in epidemic trajectories of different countries to the mitigation approach taken by governments of those countries, we made use of the COVID-19 Government Response Stringency Index developed and published by Oxford University and Blavatnik School. Results: Acceptable quality fits were obtained for all the countries with R2 mostly in excess of 0.98. Uncertainty on the final Cases and/or Deaths count is typically a factor of two early in the epidemic but this quickly reduces as the epidemic progresses. Uncertainty on Epidemic Duration also reduces but less fast. Statistics on key parameters like Epidemic Duration, Epidemic Peak and Final Mortality Rate were obtained and then cross-correlated with the rigor of government measures as recorded in the Stringency Score. Most significantly, we find a clear trend of decreasing Peak Epidemic height (and to a less extent, shorter Epidemic Duration) with increased Government Stringency at the epidemic onset. We also find that Final Mortality Rate decreases with increased Stringency of Government Testing and Contact-Tracing. Conclusions: Whilst COVID-19 epidemic trajectories for most countries are similar, some countries do have flatter and less severe trajectories than others. Our analysis suggests that mitigation measures taken by a government at the very initial stage of a COVID-19 outbreak might significantly impact severity and to a less extent duration of the epidemic.","PeriodicalId":90454,"journal":{"name":"Biology and medicine (Aligarh)","volume":"12 1","pages":"1-12"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69962429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.35248/0974-8369.20.12.476
Grace Fern, Ez
{"title":"Awards Announcement of 2nd International Conference on Glycobiology and Metabolomics","authors":"Grace Fern, Ez","doi":"10.35248/0974-8369.20.12.476","DOIUrl":"https://doi.org/10.35248/0974-8369.20.12.476","url":null,"abstract":"","PeriodicalId":90454,"journal":{"name":"Biology and medicine (Aligarh)","volume":"12 1","pages":"1-1"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69962590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-02-18DOI: 10.35248/0974-8369.19.11.456
K. Cornish, G. M. Bates, J. Slutzky, Anatoliy Meleshchuk, Wenshuang Xie, Krysta Sellers, R. Mathias, M. Boyd, Rochelle Castañeda, Michael Wright, Lise Borel
Background: Over 8% of the US population have detectable Type I hevea latex IgE antibodies and, upon exposure to natural latex and rubber products, are at risk for potentially dangerous reactions, especially in dental settings where these products meet mucosal membranes. Methods: Extractable antigenic protein levels were quantified in dental dams, examination gloves, and various other dental and rubber products. ASTM standards D6499 (antigenic protein) and D5712 (total protein) were used to quantify protein content. Results: In dental dams, extractable protein content ranged from low/non-sensitizing levels (<3 μg/dm2) to high/ sensitizing levels (130 200 μg/dm2). Also, while examination gloves from Malaysian glove manufacturers consistently exhibited a lower extractable protein content (<9 μg/dm2), than gloves from Thai manufacturers (16-23 μg/dm2) these levels should both still be non-sensitizing. There was no correlation between extractable protein content and the price or thickness of dental dams or examination gloves. Most of the other assorted dental products tested displayed low extractable protein content (<2.5 μg/dm2). Nearly all dental products made from natural rubber contained detectable antigenic Hevea proteins, subjecting previously sensitized patients and providers to risk of severe allergic reaction. A case study describes a female patient, with no previous history of Type I latex allergy, who reacted severely to a dental dam mouth exposure, necessitating her admission to the intensive care unit (ICU) of a local hospital for management of respiratory failure, with discharge after 4 days. Conclusions: Some dental products may pose a significant risk of Type I latex protein allergy sensitization, due to repeated contact, and that a single exposure can induce a severe reaction in a previously sensitized person, even when no prior latex allergy history is known.
{"title":"Extractable Protein Levels in Latex Products and their Associated Risks, Emphasizing American Dentistry","authors":"K. Cornish, G. M. Bates, J. Slutzky, Anatoliy Meleshchuk, Wenshuang Xie, Krysta Sellers, R. Mathias, M. Boyd, Rochelle Castañeda, Michael Wright, Lise Borel","doi":"10.35248/0974-8369.19.11.456","DOIUrl":"https://doi.org/10.35248/0974-8369.19.11.456","url":null,"abstract":"Background: Over 8% of the US population have detectable Type I hevea latex IgE antibodies and, upon exposure to natural latex and rubber products, are at risk for potentially dangerous reactions, especially in dental settings where these products meet mucosal membranes. \u0000 \u0000Methods: Extractable antigenic protein levels were quantified in dental dams, examination gloves, and various other dental and rubber products. ASTM standards D6499 (antigenic protein) and D5712 (total protein) were used to quantify protein content. \u0000 \u0000Results: In dental dams, extractable protein content ranged from low/non-sensitizing levels (<3 μg/dm2) to high/ sensitizing levels (130 200 μg/dm2). Also, while examination gloves from Malaysian glove manufacturers consistently exhibited a lower extractable protein content (<9 μg/dm2), than gloves from Thai manufacturers (16-23 μg/dm2) these levels should both still be non-sensitizing. There was no correlation between extractable protein content and the price or thickness of dental dams or examination gloves. Most of the other assorted dental products tested displayed low extractable protein content (<2.5 μg/dm2). Nearly all dental products made from natural rubber contained detectable antigenic Hevea proteins, subjecting previously sensitized patients and providers to risk of severe allergic reaction. A case study describes a female patient, with no previous history of Type I latex allergy, who reacted severely to a dental dam mouth exposure, necessitating her admission to the intensive care unit (ICU) of a local hospital for management of respiratory failure, with discharge after 4 days. \u0000 \u0000Conclusions: Some dental products may pose a significant risk of Type I latex protein allergy sensitization, due to repeated contact, and that a single exposure can induce a severe reaction in a previously sensitized person, even when no prior latex allergy history is known.","PeriodicalId":90454,"journal":{"name":"Biology and medicine (Aligarh)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42294490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.35248/0974-8369.19.11.455
Andualem Yimer, Belayneh Mergia Gebrmedehan
A cross-sectional study was conducted in cattle slaughtered at Debre brihan abattoir from December 2016 to April 2017. To assess bovine cysticercosis and to estimate the prevalence of Taenia saginata human infection in and around Debre brihan town, central Ethiopia Patients’ demographic data and the results of stool examinations conducted by using the formalin ethyl acetate concentration technique were collected from records at Debre brihan referral hospital. The relevant laboratory records from January 2013 to December 2017 were analyzed. Of the total 405 examined carcasses, 22 (5.43%) were found infected with various number of Cysticercus bovis in different organs. Organ distribution of the cysts showed highest proportion was observed in tongue, 7(31.81%) followed by heart 6 (27.27%) in shoulder and masseter muscles 4(18.18%) and 1 (4.54%) in liver. Significantly higher (P=0.02) proportion of counted cysts, 19(61.3%) were viable while other 12 (38.7%) were degenerated. The prevalence of C. bovis was significantly different (P<0.05) with in age categories and body condition of the slaughtered cattle. Of the total 2484 suspected patients, 97(3.9%) were stool positive for Taenia saginata eggs. The highest prevalence was 4.3% (OR=0.82, 95% CI: 0.41-1.84) in the year 2013. The prevalence gradually decreased to 3.6%(95%CI:0.47-2.4) in 2015 and slightly raised without significant difference to 3.9% and 3.7% in 2016 and 2017.The prevalence rate of taeniasis was significantly higher in male patients (4.54%, OR=1.65, 95% CI 1.08-2.53) than in females (3.32%). The results obtained in this study shows the need for integrated community based control strategies such as continuous public education and improved standards of human hygiene together with restriction of backyard slaughtering of cattle are recommended in the study areas.
{"title":"Bovine Cysticercosis and Hospital Based Retrospective Survey of Human Taeniasis in and Around Debre Brihan City, Central Ethiopia","authors":"Andualem Yimer, Belayneh Mergia Gebrmedehan","doi":"10.35248/0974-8369.19.11.455","DOIUrl":"https://doi.org/10.35248/0974-8369.19.11.455","url":null,"abstract":"A cross-sectional study was conducted in cattle slaughtered at Debre brihan abattoir from December 2016 to April 2017. To assess bovine cysticercosis and to estimate the prevalence of Taenia saginata human infection in and around Debre brihan town, central Ethiopia Patients’ demographic data and the results of stool examinations conducted by using the formalin ethyl acetate concentration technique were collected from records at Debre brihan referral hospital. The relevant laboratory records from January 2013 to December 2017 were analyzed. Of the total 405 examined carcasses, 22 (5.43%) were found infected with various number of Cysticercus bovis in different organs. Organ distribution of the cysts showed highest proportion was observed in tongue, 7(31.81%) followed by heart 6 (27.27%) in shoulder and masseter muscles 4(18.18%) and 1 (4.54%) in liver. Significantly higher (P=0.02) proportion of counted cysts, 19(61.3%) were viable while other 12 (38.7%) were degenerated. The prevalence of C. bovis was significantly different (P<0.05) with in age categories and body condition of the slaughtered cattle. Of the total 2484 suspected patients, 97(3.9%) were stool positive for Taenia saginata eggs. The highest prevalence was 4.3% (OR=0.82, 95% CI: 0.41-1.84) in the year 2013. The prevalence gradually decreased to 3.6%(95%CI:0.47-2.4) in 2015 and slightly raised without significant difference to 3.9% and 3.7% in 2016 and 2017.The prevalence rate of taeniasis was significantly higher in male patients (4.54%, OR=1.65, 95% CI 1.08-2.53) than in females (3.32%). The results obtained in this study shows the need for integrated community based control strategies such as continuous public education and improved standards of human hygiene together with restriction of backyard slaughtering of cattle are recommended in the study areas.","PeriodicalId":90454,"journal":{"name":"Biology and medicine (Aligarh)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69962035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.4172/0974-8369.1000020
S. Kausar, aAA Khan
In the present study, Interaction of different doses of SAR (pH 3.0, 4.0 and 5.0) with different inoculum levels of A. tritici showed varied responses on wheat plant. Both SAR and A. tritici interacted antagonistically. The wheat plants inoculated with lower inoculum levels (2,500, and 5,000) and exposed with lower acidity level (5.0) were not affected in terms of plant growth, yield, photosynthetic pigments, seed carbohydrate, seed protein and leaf epidermal characteristics compared to un-inoculated and un-exposed plant. While, as acidity levels (pH 4.0 and 3.0) were increased the suppressions in all above parameters were increased. However, nematodes were killed in all the doses of SAR.
{"title":"Interaction of simulated acid rain and seed gall nematode Anguina tritici on wheat","authors":"S. Kausar, aAA Khan","doi":"10.4172/0974-8369.1000020","DOIUrl":"https://doi.org/10.4172/0974-8369.1000020","url":null,"abstract":"In the present study, Interaction of different doses of SAR (pH 3.0, 4.0 and 5.0) with different inoculum levels of A. tritici showed varied responses on wheat plant. Both SAR and A. tritici interacted antagonistically. The wheat plants inoculated with lower inoculum levels (2,500, and 5,000) and exposed with lower acidity level (5.0) were not affected in terms of plant growth, yield, photosynthetic pigments, seed carbohydrate, seed protein and leaf epidermal characteristics compared to un-inoculated and un-exposed plant. While, as acidity levels (pH 4.0 and 3.0) were increased the suppressions in all above parameters were increased. However, nematodes were killed in all the doses of SAR.","PeriodicalId":90454,"journal":{"name":"Biology and medicine (Aligarh)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70916457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.4172/0974-8369.1000014
T. Khursheed, M. Ansari, D. Shahab
In present investigation, the seeds of Helianthus annuus L. variety Modern were treated with nine different concentrations (0.05%, 0.25%, 0.50%, 0.75%, 1.00%, 1.25%, 1.50%, 1.75% and 2.00%) of caffeine to raise the M1 generation and the effect of caffeine on seedling height on 30th day of sowing, mature plant height, days to maturity and yield parameters was observed. Generally, the lower doses of caffeine were found stimulatory for the seedling height on 30th day of sowing, mature plant height, days to maturity and 100-seeds weight. While, the number of seeds in treated plants showed a dose dependent increase with the increasing doses of mutagen. It shows that caffeine in its lower doses has stimulatory effect on growth and yield in Helianthus annuus L. while the higher doses have inhibitory effect and reduce the growth and yield upto some extent except number of seeds.
{"title":"Studies on the effect of caffeine on growth and yield parameters in Helianthus annuus L. variety Modern","authors":"T. Khursheed, M. Ansari, D. Shahab","doi":"10.4172/0974-8369.1000014","DOIUrl":"https://doi.org/10.4172/0974-8369.1000014","url":null,"abstract":"In present investigation, the seeds of Helianthus annuus L. variety Modern were treated with nine different concentrations (0.05%, 0.25%, 0.50%, 0.75%, 1.00%, 1.25%, 1.50%, 1.75% and 2.00%) of caffeine to raise the M1 generation and the effect of caffeine on seedling height on 30th day of sowing, mature plant height, days to maturity and yield parameters was observed. Generally, the lower doses of caffeine were found stimulatory for the seedling height on 30th day of sowing, mature plant height, days to maturity and 100-seeds weight. While, the number of seeds in treated plants showed a dose dependent increase with the increasing doses of mutagen. It shows that caffeine in its lower doses has stimulatory effect on growth and yield in Helianthus annuus L. while the higher doses have inhibitory effect and reduce the growth and yield upto some extent except number of seeds.","PeriodicalId":90454,"journal":{"name":"Biology and medicine (Aligarh)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/0974-8369.1000014","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70916640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.4172/0974-8369.1000023
V. Wankhade, A. Malu, S. Pawar
An experiment was conducted to study the effect of malathion toxicity on acetylcholinesterase activity in mice liver. Mature mice were exposed to different doses of malathion for different time period. On dissections, enzymatic estimations were done for each exposure period. It was found that, malathion inhibited the acetylcholinesterase activity in mice liver .The maximum period of exposure was upto 30 days. The degree of inhibition increased upto 4 days of exposure period but declined later on. There was maximum recovery of AChE activity by 30th day of exposure. These findings indicate that the continuous and prolonged exposure to sublethal dose of malathion resulted in the recovery of AChE activity.
{"title":"Effect of malathion on liver ache activity of mice","authors":"V. Wankhade, A. Malu, S. Pawar","doi":"10.4172/0974-8369.1000023","DOIUrl":"https://doi.org/10.4172/0974-8369.1000023","url":null,"abstract":"An experiment was conducted to study the effect of malathion toxicity on acetylcholinesterase activity in mice liver. Mature mice were exposed to different doses of malathion for different time period. On dissections, enzymatic estimations were done for each exposure period. It was found that, malathion inhibited the acetylcholinesterase activity in mice liver .The maximum period of exposure was upto 30 days. The degree of inhibition increased upto 4 days of exposure period but declined later on. There was maximum recovery of AChE activity by 30th day of exposure. These findings indicate that the continuous and prolonged exposure to sublethal dose of malathion resulted in the recovery of AChE activity.","PeriodicalId":90454,"journal":{"name":"Biology and medicine (Aligarh)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70916846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.35248/0974-8369.19.11.452
H. Hasanov, K. Mammadova, F. Guliyeva, U. Azizova, N. Mikailova
MMPs are Zn dependent proteases. All of MMPs kind is multi-domain proteins and their activities are regulated by tissue inhibitors of metalloproteinases. The prevention of the pathologies which is created by MMPs used some synthetic and naturally inhibitors. This review will explain the attitude MMPs and some chemical and physical factors which to being high level and low could affect to MMPs activity and synthesis as caffeine, one of snake venom components, melatonin, serotonin, stress factor, E and C vitamins.
{"title":"The Role of Matrix Metalloproteinases in Human Body","authors":"H. Hasanov, K. Mammadova, F. Guliyeva, U. Azizova, N. Mikailova","doi":"10.35248/0974-8369.19.11.452","DOIUrl":"https://doi.org/10.35248/0974-8369.19.11.452","url":null,"abstract":"MMPs are Zn dependent proteases. All of MMPs kind is multi-domain proteins and their activities are regulated by tissue inhibitors of metalloproteinases. The prevention of the pathologies which is created by MMPs used some synthetic and naturally inhibitors. This review will explain the attitude MMPs and some chemical and physical factors which to being high level and low could affect to MMPs activity and synthesis as caffeine, one of snake venom components, melatonin, serotonin, stress factor, E and C vitamins.","PeriodicalId":90454,"journal":{"name":"Biology and medicine (Aligarh)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69961857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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