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Nutritional Health: Strategies for Disease Prevention 营养健康:疾病预防战略
Pub Date : 2023-01-01 DOI: 10.1007/978-3-031-24663-0
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引用次数: 1
Prevalence and Associated Factors of Vitamin A Deficiency among Children and Women in Senegal 塞内加尔儿童和妇女维生素A缺乏症的患病率及其相关因素
Pub Date : 2020-06-21 DOI: 10.15226/JNHFS.2020.001176
M. H. Faye, Nicole Idohou-Dossou, A. Badiane, Anta Agne-Djigo, P. M. Sylla, A. Diouf, A. Guiro, S. Wade
Background: Like many developing countries, Senegal does not have data on the extent of vitamin A deficiency (VAD) that is representative of its population. The present survey was conducted to fill this gap and to identify factors associated with VAD, prior to the introduction of a large-scale vitamin A oil fortification program. Procedures: A nationwide representative cross-sectional survey involving 1887 children 12 to 59 months old and 1316 women of reproductive age (WRA) was conducted. Blood samples were collected and plasma concentrations of retinol (PR), C-reactive protein (CRP), and alpha-1-acidglycoprotein were measured. PR was adjusted for subclinical inflammation using the BRINDA regression methodology. Multivariate logistic regression was used to identify factors associated with VAD. Findings: The adjusted prevalence of VAD (PR ≤ 0.7 μmol/L) in children was 15.3% and differed by age group, area of residence, and socioeconomic status and half of them had subclinical inflammation. Among WRA, VAD was low (2.3%) and 18.1% had vitamin A insufficiency (VAI). Pregnant women were more affected by VAI (28.4%) and Dakar had lower figures compared with other cities and rural strata. Prevalence of VAI decreased with increasing wealth quintile. In logistic regression, abnormal CRP, poverty, scarce consumption of poultry, oysters, melon, red palm oil, palm kernel oil, Saba senegalensis fruit pulp (Maad) and cowpea, frequent consumption of leeks and consumption of Leptadenia hastata leaves (Mbuum tiakhat), were associated with VAD in children. For women, lower socioeconomic status, fair or poor health status and anemia were negatively associated with VAI. Conclusions: In Senegal, VAD is a moderate public health problem in children and slight among women. Particular attention should be paid to children older than 23 months, pregnant women, rural populations, and poorest households. Nutritional interventions should be implemented alongside morbidity prevention and control. Keywords: vitamin A deficiency, children 12-59 months, women of reproductive age, Senegal.
背景:与许多发展中国家一样,塞内加尔没有代表其人口的维生素A缺乏程度的数据。在引入大规模维生素a油强化计划之前,本次调查旨在填补这一空白,并确定与VAD相关的因素。程序:对1887名12至59个月大的儿童和1316名育龄妇女进行了一项具有全国代表性的横断面调查。采集血样,测量血浆视黄醇(PR)、C反应蛋白(CRP)和α-1-酸糖蛋白的浓度。使用BRINDA回归方法对PR进行亚临床炎症调整。多变量逻辑回归用于确定与VAD相关的因素。研究结果:儿童VAD(PR≤0.7μmol/L)的校正患病率为15.3%,因年龄组、居住地区和社会经济地位而异,其中一半患有亚临床炎症。在WRA中,VAD较低(2.3%),18.1%患有维生素A缺乏症(VAI)。孕妇受VAI的影响更大(28.4%),与其他城市和农村阶层相比,达喀尔的数字更低。VAI的患病率随着财富五分位数的增加而下降。在logistic回归中,异常CRP、贫困、家禽、牡蛎、甜瓜、红棕榈油、棕榈仁油、塞内加尔沙巴果浆(Maad)和豇豆的稀缺消费、韭菜的频繁消费和哈氏钩端叶(Mbuum tiakhat)的消费与儿童VAD相关。对于妇女来说,社会经济地位较低、健康状况尚可或较差以及贫血与VAI呈负相关。结论:在塞内加尔,VAD在儿童中是一个中度公共卫生问题,在妇女中是轻微的。应特别关注23个月以上的儿童、孕妇、农村人口和最贫穷的家庭。应在预防和控制发病率的同时实施营养干预措施。关键词:维生素A缺乏症,12-59个月的儿童,育龄妇女,塞内加尔。
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引用次数: 2
Seasonal Variation of Nutritional Intake from 24-Hour Urine Collection and Adherence in Patients with Chronic Kidney Disease 慢性肾病患者24小时尿液收集营养摄入的季节变化及依从性
Pub Date : 2020-01-07 DOI: 10.15226/jnhfs.2019.001167
Y. Kanno, R. Onda, Y. Nagaoka, Yoshitaka Miyaoka, T. Okada, Asako Gondo, M. Nagai, E. Kanda
Background: For appropriate diet therapy, it is desirable to determine urine volume and excreted urinary components using 24-hour urine volume (24hUV) and compare these data with indications. 24hUV allows an accurate measurement of excreted urinary protein, glucose, and salt per day, which are important for assessment of renal function and diet intake. In particular, urine volume may be seasonal variations because of the effect of perspiration. Methods: The subjects were 37 (29 males and 8 females) outpatients with chronic kidney disease (CKD) who underwent 24-hour urine collection and were given nutrition education (consultation) continuously for 2 years or more. The survey period was January 2012 to July 2014. Patients were divided into 3groups according to their adherence to indicated intake as A, <15% difference, B, ≥15%. Results: There was no significant difference in 24hUV and urinalysis between seasons. Mean Na throughout the year was 82±29 mEq/L, and Mean K throughout the year was 20.4±9.4 mEq/L. Estimated protein and salt intake were lower in group A throughout the year. Conclusion: Urine 24hUV and urinalysis were not influenced by seasonal variations, and these findings were due to the influence of diet intake.
背景:对于适当的饮食治疗,需要用24小时尿量(24hUV)来测定尿量和排泄的尿液成分,并将这些数据与适应症进行比较。24hUV可以精确测量每天排出的尿蛋白、葡萄糖和盐,这对评估肾功能和饮食摄入量很重要。特别是,尿量可能因排汗的影响而随季节变化。方法:选取37例慢性肾脏疾病(CKD)门诊患者(男29例,女8例),24小时取尿,并连续2年以上进行营养教育(咨询)。调查时间为2012年1月至2014年7月。根据患者对指示摄入量的依从性分为A组,差异<15%,B组,差异≥15%。结果:不同季节患者24hUV及尿液分析无显著差异。全年平均Na为82±29 mEq/L,全年平均K为20.4±9.4 mEq/L。A组全年估计的蛋白质和盐摄入量较低。结论:尿24hUV和尿液分析不受季节变化的影响,这些发现是由于饮食摄入的影响。
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引用次数: 1
Extraction and Antioxidant Activity Evaluation of Polyphenols of Brown Rice Tea from Japonica Rice and Indica Rice 粳稻和籼稻糙米茶中多酚的提取及抗氧化活性评价
Pub Date : 2020-01-01 DOI: 10.15226/jnhfs.2020.001172
Shuangqi Tian, Zhicheng Chen, Kejing Yang
The objective of this study was to explore the extraction process and antioxidant activity of polyphenols from Japonica and Indica brown rice. After baking, Japonica and Indica brown rice samples were soaked in water to obtain brown rice tea respectively. We determined the polyphenol content and the antioxidant activity of the brown rice tea, as well as measured the contents of nutrients (including protein, amino acid, and crude cellulose) of the baked brown rice. The total AA content of Indica brown rice (7.30%) was higher than that of Japonica brown rice (6.30%). The results showed that the optimum extraction conditions for Japonica and Indica rice polyphenols were as follows: baking temperature of 180°C and 190°C, baking time of 15 min and 20 min, and soaking time of 30 min and 30 min, respectively. The DPPH clearance rate of the five samples was shown as follows: Burdock tea> Pu’er tea> Tieguanyin tea> Japonica brown rice> Indica brown rice tea. The DPPH clearance rate of the polyphenols in rice tea obtained from Japonica and Indica brown rice was 1.04% and 1.99%.
研究了粳稻和籼稻糙米中多酚的提取工艺及其抗氧化活性。烘培后,粳稻和籼稻糙米样品分别在水中浸泡,得到糙米茶。测定了焙烤糙米茶的多酚含量和抗氧化活性,并测定了焙烤糙米的营养成分(包括蛋白质、氨基酸和粗纤维素)含量。籼米总AA含量(7.30%)高于粳米(6.30%)。结果表明,粳稻和籼稻多酚的最佳提取条件为:烘烤温度180℃和190℃,烘烤时间15 min和20 min,浸泡时间30 min和30 min。5种样品的DPPH清除率为:牛蒡茶bb0普洱茶bb1铁观音茶bb2粳稻糙米bb3籼稻糙米茶。粳米和籼米茶中多酚类物质的DPPH清除率分别为1.04%和1.99%。
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引用次数: 1
The Anti-Obesity Effect of Kaempferia Parviflora (KP) is Attributed to Leptin in Adipose Tissue 山奈的抗肥胖作用归因于脂肪组织中的瘦素
Pub Date : 2019-06-25 DOI: 10.15226/jnhfs.2019.001158
M. Miyazaki, N. Izumo, K. Yoshikawa, Takuya Matsugami, Yuko Miyadate, K. Hayamizu, Yasuo Watanabe
Kaempferia parviflora (KP) (black ginger) is a plant in Thailand known historically as Kurachai Dam. It belongs to the ginger family and was used as a remedy medicine. Its rhizomes were used to improve obesity, blood flow, inflammation, allergy, and gastrointestinal disorders. However, the mechanism of its anti-obesity effect has not been elucidated. In this study, our purpose was to explore the visceral fat reduction mechanism of KP in vivo. Five weeks old C57BL/6J male mice were used. The mice were fed for 8 weeks with a test food limited to 3 g/day/mouse. We divided the mice into 4 groups as follows: 1 normal diet group (controls), 2 high fat diet group (HFD), 3 high fat diet + 0.5% black ginger extract group (HFD + KP 0.5%), and 4 high fat diet + black ginger extract 1.0% group (HFD + KP 1.0%). At the end of the 8th week, the visceral fat of the mice was collected and weighed and the expression levels of adiponectin, leptin, IL-6, and IL-1β in adipose tissues were measured by RT-PCR. Leptin and IL-6 expressions were decreased with a significant difference between group 4 and group 2. Adiponectin expression was significantly higher in group 4 than in group 2. The present study indicated that the anti-obesity effect of KP in vivo normalizes the function of leptin by suppressing its resistance upon ingestion of high-fat meals and inhibits fat accumulation by thermogenesis in brown adipocytes.
小山奈(KP)(黑姜)是泰国的一种植物,历史上被称为库拉猜大坝。它属于姜科,被用作一种治疗药物。其根茎被用于改善肥胖、血液流动、炎症、过敏和胃肠道疾病。然而,其抗肥胖作用的机制尚未阐明。在本研究中,我们的目的是探索KP在体内减少内脏脂肪的机制。使用5周龄的C57BL/6J雄性小鼠。用限制为3g/天/只的试验食物喂养小鼠8周。我们将小鼠分为4组:1组为正常饮食组(对照组),2组为高脂饮食组(HFD),3组为高脂肪饮食+0.5%黑姜提取物组(HFD+KP 0.5%),RT-PCR检测脂肪组织中IL-1β的表达。瘦素和IL-6的表达在第4组和第2组之间有显著差异。第4组的脂联素表达显著高于第2组。本研究表明,KP在体内的抗肥胖作用通过抑制瘦素在摄入高脂肪食物时的抵抗力使其功能正常化,并通过产热抑制棕色脂肪细胞中的脂肪积累。
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引用次数: 3
Pathways for Reducing Anti-Nutritional Factors: Prospects for Vigna unguiculata 减少抗营养因子的途径:马蹄苋的前景
Pub Date : 2019-05-27 DOI: 10.15226/JNHFS.2019.001157
A. Diouf, F. Sarr, B. Sene, C. Ndiaye, S. M. Fall, N. Ayessou
Cereals, pulses and legumes are the most consumed foods in SubSaharan Africa. Cowpea, Vigna unguiculata (L.) walp is one known of these legumes as a good source of proteins, some minerals, and fibers. However, the presence of anti-nutritional factors (ANFs) including phytates, alpha galactosides such as raffinose and stachyose, and tannins reduce significantly the micronutrients and also create some problems of acceptability in using cowpea and other legumes. This review article rep the current knowledges on key aspects of technologies used to reduce ANFs. Some of them proposed one either pathway or combining many techniques such as soaking, sprouting, fermentation, extrusion cooking and steam pre-cooking in order to reduce these ANFs. In fact, steam pre-cooking seems to be the most promising among established processes because of its potential to reduce ANFs up to 96%. Nevertheless, soaking can reduce ANFs up to 45% with higher reductions by adding sodium bicarbonate. Sprouting however can record more significant reductions of 33 to 72% of tannins, 96% of phytates, 92% of stachyose and 67% of raffinose. With regard to fermentation, a reduction rate in ANFs exceeding 50% was found. The extrusion technic reduces up to 55.83% at 140 ° C and 20% humidity while the steam pre cooking resulted reductions of up to 52.60% at 110 ° C for 25 minutes. In this regard, it is critical to investigate mechanisms that would improve these reductions and furthermore, investigate all strategies used to increase bioavailability of nutrients under specific technological condition.
谷物、豆类和豆类是撒哈拉以南非洲消费最多的食物。豇豆(Vigna unguiculata, L.) walp是这些豆科植物中的一种,它是蛋白质、一些矿物质和纤维的良好来源。然而,抗营养因子(ANFs)的存在,包括植酸盐、α半乳糖苷(如棉子糖和水苏糖)和单宁,大大减少了微量营养素的含量,也给豇豆和其他豆类的食用带来了一些可接受性问题。这篇综述文章代表了目前用于减少anf的关键技术方面的知识。有些人提出了一种途径或结合浸泡、发芽、发酵、挤压蒸煮和蒸汽预蒸煮等多种技术来减少这些ANFs。事实上,蒸汽预煮似乎是现有工艺中最有前途的,因为它有可能减少高达96%的anf。然而,浸泡可以降低ANFs高达45%,添加碳酸氢钠的降幅更高。然而,发芽可以显著减少33%至72%的单宁,96%的植酸盐,92%的水苏糖和67%的棉子糖。在发酵方面,发现ANFs的还原率超过50%。在140°C和20%的湿度下,挤压技术减少了55.83%,而蒸汽预煮在110°C、25分钟下减少了52.60%。在这方面,研究改善这些减少的机制是至关重要的,此外,研究在特定技术条件下用于提高营养物质生物利用度的所有策略。
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引用次数: 16
Quantitative Analysis of Selenium in Staple Foodstuffs from Kanam Local Government Area, North-Central Nigeria 尼日利亚中北部卡纳姆地方政府地区主要食品中硒的定量分析
Pub Date : 2019-05-17 DOI: 10.15226/jnhfs.2019.001156
Kiri H. Jaryum, Z. Okoye, B. Stoecker
Background: Although selenium was, for decades, considered toxic, many animal diseases has been found to respond to selenium. Selenium is, therefore, an essential trace element. Selenium is essential for human nutrition where it is a constituent of more than two dozen selenoproteins that play critical roles in reproduction, thyroid hormone metabolism, DNA synthesis, and protection from oxidative damage and infection. Selenium concentrations in plantbased foods vary widely by geographic location. This research was aimed at determining the amount of selenium in the local foodstuffs from Kanam Local Government Area in north-central Nigeria. Methods: Staple foodstuffs were selected across all the sections of the research area. Samples were homogenized in a ceramic mortar to obtain homogeneous samples with particle size > 300μm. These were digested using a diluted oxidant mixture containing 1 ml deionised H2O + 0.5 ml double-distilled HNO3. Selenium content was determined using the inductively coupled-mass spectrophotometry technique. Data obtained were analysed using the student’s t-test and results were presented as means and standard deviations. A probability level of p < 0.05 was considered statistically significant. Results: All the foodstuffs contained quantities of selenium high enough to meet the recommended daily allowance for all categories. Grain varied widely in their selenium content with white sorghum containing the lowest (6.16±3.97 μg/g) and red sorghum containing the highest (14.19±7.22 μg/g) followed by cowpea (13.05±8.79 μg/g). Conclusion: These values suggest that a diet well balanced in other nutrients is probably also nutritionally adequate with regard to selenium, although possible effects of cooking, processing, geographical variation and biological availability remain to be investigated.
背景:虽然几十年来硒一直被认为是有毒的,但许多动物疾病已被发现对硒有反应。因此,硒是人体必需的微量元素。硒对人体营养至关重要,它是二十多种硒蛋白的组成部分,在生殖、甲状腺激素代谢、DNA合成以及防止氧化损伤和感染方面发挥着关键作用。植物性食物中的硒含量因地理位置而异。本研究旨在测定尼日利亚中北部卡纳姆地方政府区当地食品中的硒含量。方法:在研究区域的所有区域选择主食。样品在陶瓷砂浆中均质,得到粒径为> ~ 300μm的均匀样品。用含有1ml去离子水+ 0.5 ml双蒸馏HNO3的稀释氧化剂混合物消化。采用电感耦合质谱法测定硒的含量。获得的数据使用学生t检验进行分析,结果以均值和标准差表示。概率水平p < 0.05认为有统计学意义。结果:所有食品中硒的含量都足以满足所有类别的每日推荐量。籽粒硒含量差异较大,其中白高粱硒含量最低(6.16±3.97 μg),红高粱硒含量最高(14.19±7.22 μg),豇豆硒含量最高(13.05±8.79 μg)。结论:这些数值表明,尽管烹饪、加工、地理差异和生物有效性等因素可能对硒的影响仍有待调查,但膳食中其他营养素的平衡也可能使硒的营养充足。
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引用次数: 0
Enhanced Anti-Inflammatory Effects by Glucans Extracted from the Stalks of Pleurotus Eryngii Grown In Substrates Containing Olive Mill Waste 从含有橄榄废料的基质中生长的杏鲍菇茎中提取的葡聚糖增强抗炎作用
Pub Date : 2019-05-16 DOI: 10.15226/jnhfs.2019.001155
Ofer Gover, Hilla Hayby, A. Levy, E. Fishman, O. Danay, N. Ezov, Y. Hadar, V. Vetvicka, B. Schwartz
We recently demonstrated that the mushroom Pleurotus eryngii grown on a substrate containing increasing concentrations of olive mill solid waste (OMSW) contain greater glucan concentrations as a function of OMSW content. Treatment of rat Intestinal epithelial cells (IEC-6) transiently transfected with Nf-κB fused to luciferase demonstrated that glucans extracted from P. eryngii stalks grown on 80% OMSW down regulated TNF-α activation. Glucans from mushrooms grown on 80% OMSW exerted the most significant reducing activity of nitric oxide production in lipopolysaccharide (LPS) treated J774A.1 murine macrophages. The isolated glucans were tested in vivo using the Dextran Sodium Sulfate (DSS) induced colitis in C57Bl/6 mice and found to reduce the histology damaging score resulting from DSS treatment. Expressions of various intestinal cytokines were efficiently down regulated by treatment with the fungal extracted glucans. We conclude that the stress-induced growing conditions exerted by OMSW induce production of more effective anti-inflammatory glucans in P. eryngii stalks.
我们最近证明,在含有更高浓度的橄榄磨固体废物(OMSW)的基质上生长的蘑菇Pleurotus eryngii含有更高的葡聚糖浓度,这是OMSW含量的函数。用Nf-κB与荧光素酶融合处理的大鼠肠上皮细胞(IEC-6)表明,80% OMSW生长的P. yyngii茎中提取的葡聚糖可下调TNF-α的激活。对J774A处理的脂多糖(LPS),生长在80% OMSW上的蘑菇葡聚糖对一氧化氮生成的抑制作用最为显著。1小鼠巨噬细胞。用葡聚糖硫酸钠(DSS)诱导C57Bl/6小鼠结肠炎进行体内实验,发现分离的葡聚糖可降低DSS治疗引起的组织学损伤评分。真菌提取的葡聚糖有效地下调了肠道细胞因子的表达。我们得出的结论是,OMSW施加的胁迫诱导生长条件可诱导P. yyngii秸秆产生更有效的抗炎葡聚糖。
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引用次数: 2
Effect of Coriandrum Sativum L. Leaf Extract on the Brain GABA Neurons in Mice 芫荽叶提取物对小鼠脑GABA神经元的影响
Pub Date : 2019-05-02 DOI: 10.15226/jnhfs.2019.001154
J. Sakùrai, N. Izumo, Yasuo Watanabe
We have evaluated the mechanism underlying the sedative effects of coriander (Coriandrum sativum L.) using a behavioral study and real-time PCR (RT-PCR). The experimental mice were divided as: (1) control, (2) coriander leaf extract400 or 600 mg/kg, (3) coriander seed extract400 or 600 mg/kg, (4) main ingredients. Two hours after oral administration of coriander extracts and main ingredients, a light anesthesia (21.6 mg/kg) of pentobarbital was administered intraperitoneally (i.p.) to all mice. The time points recorded after i.p. administrations were1: immediately after administration, 2: start time of somnolence, 3: end time of somnolence. The brains were isolated from the control and coriander leaf extract groups two hours after oral administration for RT-PCR. Pentobarbital-induced somnolence duration time was compared with that of the control group. A significant difference was found in leaf and seed extract600 mg/kg group and linalool (main ingredient of coriander) group. RT-PCR results showed that the gene expression of GABAA receptor β1 subunit was significantly increased and the gene expression of GABA transporter was significantly decreased in leaf extract 600 mg/kg group. This indicates that the sedative effect of coriander leaf extract is due to the hyperactivity of inhibitory neurons in the brain.
我们使用行为研究和实时PCR(RT-PCR)评估了香菜(Coriandrum sativum L.)镇静作用的潜在机制。实验小鼠分为:(1)对照组,(2)香菜叶提取物400或600mg/kg,(3)香菜籽提取物400或600mm,(4)主要成分。在口服香菜提取物和主要成分两小时后,对所有小鼠腹膜内(i.p.)给予轻度麻醉(21.6mg/kg)戊巴比妥。腹膜内给药后记录的时间点为1:给药后立即,2:嗜睡开始时间,3:嗜睡结束时间。在口服给药两小时后,从对照组和香菜叶提取物组中分离大脑进行RT-PCR。将戊巴比妥诱导的嗜睡持续时间与对照组进行比较。叶籽提取物600mg/kg组与香菜主要成分芳樟醇组比较有显著性差异。RT-PCR结果显示,叶提取物600mg/kg组GABAA受体β1亚基基因表达显著增加,GABA转运蛋白基因表达显著降低。这表明香菜叶提取物的镇静作用是由于大脑中抑制性神经元的过度活跃。
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引用次数: 4
Anti-Obesity Effects of Sticky Japanese Diet (SJD) Assessed by Regulations of Leptin and Adiponectin 通过瘦素和脂联素的调节评价粘性日本饮食(SJD)的抗肥胖作用
Pub Date : 2019-04-16 DOI: 10.15226/JNHFS.2019.001153
Y. Hirokawa, N. Izumo, M. Hashimoto, Shogo Tawara, H. Mori, Yurina Mima, K. Kuwahata, Kazuya Watanabe, K. Tsuzuki, Yasuo Watanabe
Background: Recently, we published a book which describes about the anti-obesity efficacy of the “Nuruneba Diet (Sticky Japanese Diet; SJD)”. Along with the contents of this book, the dried SJD was developed and marketed. When this marketed SJD was fed daily to obese mice, the effect of suppressing weight gain and reducing visceral fat were observed. Furthermore, we evaluated its mechanism for enhancing the leptin production. In this study, we clarify the different effects of SJD on between normal diet mice and high fat diet mice, and its mechanism was investigated focusing on adiponectin and leptin system. Methods: 5-week-old male ICR strain mice were divided as follows: normal diet group (CE-2 group), normal diet and nuruneba (SJD) diet group (CE-2 + SJD group), high-fat diet group (HFD group), high-fat diet and Nuruneba diet it was divided into four groups (HFD + SJD group). Each group, food and water were pre-fed individually for one week and then allowed to free access to food and water for eight weeks. At the end of the treatment period, the visceral fat was collected. The triglyceride and cholesterol concentrations were determined from plasma and the expression levels of adipocytokines in visceral fat were measured by PCR. Results: Body weight gain was observed in the HFD group, and significant suppression of body weight gain was observed in the HFD + SJD group from the third week after intake. The visceral fat was significantly increased in the HFD group compared to the CE-2 group, and significant suppression was observed in the HFD + SJD group. The effects on adipocytokines were measured for adiponectin and leptin mRNA expression. In adiponectin, the expression was significantly increased in CE-2 + SJD group compared with CE-2 group. The expression level of leptin was significantly increased in the HFD group compared to the CE-2 group, and that of leptin was significantly suppressed in the HFD + SJD. Conclusion: These results suggest that daily intake of SJD activates adiponectin secretion under normal conditions and has an obesity preventive effect and that obesity is prevented by suppressing leptin resistance in the obese state.
背景:最近,我们出版了一本书,介绍了“粘性日本饮食”(Nuruneba Diet;SJD)”。随着这本书的内容,干燥的SJD被开发和销售。当这种上市的SJD每天喂给肥胖小鼠时,观察到抑制体重增加和减少内脏脂肪的效果。此外,我们评估了其促进瘦素产生的机制。在本研究中,我们阐明了SJD对正常饮食小鼠和高脂饮食小鼠的不同影响,并从脂联素和瘦素系统角度探讨了其作用机制。方法:将5周龄雄性ICR品系小鼠分为正常饲粮组(CE-2组)、正常饲粮加努鲁内巴(SJD)饲粮组(CE-2 + SJD组)、高脂饲粮组(HFD组)、高脂饲粮加努鲁内巴饲粮4组(HFD + SJD组)。每组分别预喂食物和水一周,然后允许自由获取食物和水八周。在治疗期结束时,收集内脏脂肪。血浆测定甘油三酯和胆固醇浓度,用PCR法测定内脏脂肪中脂肪细胞因子的表达水平。结果:HFD组体重增加,HFD + SJD组从摄入后第3周开始体重增加得到明显抑制。与CE-2组相比,HFD组内脏脂肪明显增加,HFD + SJD组内脏脂肪明显减少。测定脂联素和瘦素mRNA表达对脂肪细胞因子的影响。脂联素方面,CE-2 + SJD组较CE-2组表达明显升高。与CE-2组相比,HFD组瘦素表达水平明显升高,HFD + SJD组瘦素表达水平明显抑制。结论:上述结果提示,正常情况下每日摄入SJD可激活脂联素分泌,具有预防肥胖作用,肥胖状态下通过抑制瘦素抵抗来预防肥胖。
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引用次数: 2
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Journal of nutritional health & food science
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