BMC Oral Health最新文献

Aim: This study aimed to determine the clinical and radiographic efficacy of custom-made 3D PEEK plates in comparison with 3D titanium plates for the management of mandibular angle fractures.

Patients and methods: Eighteen patients with recent mandibular angle fractures indicated for open reduction and internal fixation were randomly allocated into two groups. The study group (n = 9) underwent fixation with custom-made 3D PEEK plates, while the control group (n = 9) received prebent 3D titanium plates adapted on virtually reduced models. Primary outcomes were bite-force recovery and bone-density (Hounsfield units, HU) at the fracture line measured on CT immediately post-op and at 12 weeks. Secondary outcomes included operative time, occlusion, interfragmentary stability and wound healing.

Results: By the end of follow-up, Bite force increased significantly over time in both groups (p < 0.001) with no between-group differences at any time point. Mean bone density increased from 811.1 ± 68.2 HU to 1225.1 ± 111.7 HU in the PEEK group and from 809.0 ± 62.1 HU to 1248.3 ± 92.3 HU in the titanium group (p < 0.001); between-group differences were not significant. Operative time, occlusion outcomes and wound healing were similar between both groups.

Conclusion: Custom-made 3D PEEK plates achieved comparable clinical, radiographic, and functional outcomes to 3D titanium plates, suggesting that PEEK is a viable alternative for mandibular angle fracture fixation.

Trial registration: Trial registered at (ClinicalTrials.gov/NCT07156812/2025-08-28).

Background: Periodontitis has increasingly been recognized for its impact on systemic health. Mendelian Randomization (MR), an emerging causal inference method, effectively overcomes confounding biases in observational studies. To systematically evaluate the causal relationship between periodontitis and various systemic diseases through a meta-analysis of mendelian randomization studies.

Methods: The China National Knowledge Infrastructure, WanFang data, PubMed, Web of Science and Science Direct were searched for mendelian randomization studies on periodontitis in relation to systemic disorders. Meta-analysis was performed on data gathered using the inverse-variance weighted and mendelian randomization-Egger methods.

Results: A total of 610 records was screened. The systematic review included 78 mendelian randomization experiments, while the meta-analysis included 34. There was strong evidence linking periodontitis to an increased risk of cardioembolic stroke and depression. However, the data showed that periodontitis had no substantial causal association with Alzheimer's disease, Parkinson's disease, coronary atherosclerosis, rheumatoid arthritis, hypothyroidism, hyperthyroidism, gastric cancer, psoriasis, Sjögren's syndrome, or inflammatory bowel disease.

Conclusions: The evidence from mendelian randomization studies suggests that periodontitis plays a causal role in in cardioembolic stroke and depression. However, the rest of the findings differ from those of earlier observational research. As a result, future research should focus on resolving these constraints using bigger, more diverse populations and investigating the molecular mechanisms behind the observed relationships.

Trial registration: The PROSPERO database lists this meta-analysis under the registration number CRD42024581585.