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MORPHOFUNCTIONAL FEATURES OF THE PLACENTA IN PREGNANT WOMEN WITH TUBERCULOSIS 肺结核孕妇胎盘的形态功能特征
Pub Date : 2023-01-01 DOI: 10.25005/2074-0581-2023-25-3-314-324
VALDOSHOVA S.SH.
Objective: To study the morphology of the placenta in pregnant women with TB Methods: The morphology of the 26 placentas was evaluated in this study, out of which 15 were from women with various forms and localizations of TB (main group), while 11 were from healthy pregnant women (control group). The placentas were evaluated macroscopically. Central and peripheral zones of the placenta and umbilical cord were sampled and embedded in paraffin. Histological slides were stained with hematoxylin-eosin and examined using an Olympus CX-21 microscope with a Universal Infinity Optical System (UIS2). Results: Women in the main group were significantly more commonly underweight (p<0.01) compared to the control group. They also showed a significantly higher frequency of decompensated chronic placental insufficiency (PI), increased share of immature intermediate differentiated villi, dystrophic and degenerative changes in the placenta (foci of dystrophic calcification, afunctional syncytial nodules), and circulatory disorders (ischemic necrosis, fibrinoid in the intervillous space). Foci of calcification and infarctions in the villi embedded in fibrinoid were also significantly more common in the main group. Compensatory changes included pronounced angiomatosis, hypervascularization of villi, an increase in the number of terminal villi, the formation of synticiocapillary membranes, and functional syncytial nodules Conclusion: TB in pregnant women leads to morphological and functional changes in the placenta (delayed villous maturation, disorders of the uteroplacental circulation) and the development of more severe forms of chronic PI. The compensatory changes in the placenta might not sustain the required level of its blood supply, which results in deterioration of the perinatal outcomes (intrauterine growth restriction – IUGR).
目的:研究TB孕妇胎盘形态。方法:对26例TB孕妇胎盘形态进行评价,其中15例来自不同形式和部位的TB(主要组),11例来自健康孕妇(对照组)。对胎盘进行宏观评价。取胎盘和脐带的中心和外周区域,石蜡包埋。组织切片用苏木精-伊红染色,使用Olympus CX-21显微镜,采用通用无限远光学系统(UIS2)检查。结果:与对照组相比,主组女性体重过轻的发生率明显高于对照组(p < 0.01)。他们还表现出失代偿性慢性胎盘功能不全(PI)的频率明显更高,未成熟的中间分化绒毛的比例增加,胎盘营养不良和退行性改变(营养不良钙化灶,功能性合胞结节)和循环障碍(缺血性坏死,绒毛间隙纤维蛋白样)。在主组中,纤维蛋白包裹绒毛内的钙化灶和梗死灶也明显更常见。代偿性改变包括明显的血管瘤病、绒毛血管充血、末端绒毛数量增加、合胞膜形成和功能性合胞结节。结论:孕妇结核可导致胎盘形态和功能改变(绒毛成熟延迟、子宫胎盘循环障碍)和更严重形式的慢性PI的发展。胎盘的代偿性变化可能无法维持所需的血液供应水平,从而导致围产期结局的恶化(宫内生长限制- IUGR)。
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引用次数: 0
INTRADURAL HYPOGLOSSAL SCHWANNOMA WITHOUT HYPOGLOSSAL PARALYSIS AND TONGUE ATROPHY: A CASE STUDY AND LITERATURE REVIEW 无舌下麻痹及舌萎缩之硬膜内舌下神经鞘瘤一例及文献回顾
Pub Date : 2023-01-01 DOI: 10.25005/2074-0581-2023-25-2-278-287
П.Г. Руденко, П. Г. Шнякин, А.В. БотоВ, е. МилёхинА, М.н. ФАйзоВА, P. G. Rudenko, P. Shnyakin, V. Botov, E. Milyokhina, M. Fayzova, Gennadievich, Botov Anton, Vitalievich, Milyokhina Ilona, Evgenievna, V. F. Voyno-Yasenetsky
Hypoglossal nerve (HyN) schwannomas are uncommon tumors. The leading symptoms are unilateral tongue weakness and atrophy. The neoplasms are diagnosed by MRI imaging. The surgical treatment of hypoglossal schwannomas (HS) is challenging because the tumor is closely related to brainstem structures, cranial nerves, and arteries of the vertebrobasilar system. Their removal is associated with a high risk of patient disability. This report presents a clinical case study of a 68-year-old patient with an unusual clinical presentation of intradural HS. There were no signs of tongue weakness or atrophy observed in the patient. After the tumor was diagnosed, it was radically removed. This case highlights the importance of early detection and complete microsurgical resection of schwannoma to prevent neurological deficits and ensure a favorable postoperative outcome, thus maintaining the patient's quality of life. Keywords: Hypoglossal nerve, schwannoma, tongue weakness and atrophy, microsurgery.
舌下神经鞘瘤是一种少见的肿瘤。主要症状是单侧舌头无力和萎缩。肿瘤通过核磁共振成像诊断。舌下神经鞘瘤(HS)的手术治疗具有挑战性,因为肿瘤与脑干结构、颅神经和椎基底系统动脉密切相关。切除它们与患者残疾的高风险相关。本报告提出了一个临床病例研究的68岁患者的临床表现不寻常的硬膜内HS。患者未见舌头无力或萎缩的迹象。肿瘤确诊后,就被彻底切除了。本病例强调了神经鞘瘤的早期发现和完全显微手术切除对于预防神经功能缺损和确保良好的术后预后,从而维持患者的生活质量的重要性。关键词:舌下神经,神经鞘瘤,舌无力萎缩,显微外科。
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引用次数: 0
MODERN ASPECTS OF NONPARASITIC LIVER CYSTS 非寄生虫性肝囊肿的现代研究
Pub Date : 2023-01-01 DOI: 10.25005/2074-0581-2023-25-3-390-399
I.A. KOPYTIN, V.V. IVANOV, V.B. FILIMONOV, G.Y. ZHURAVLYOV, V.S. FOMIN, I.V. ABRAMOV
Methods: The relevance of nonparasitic cysts of the liver (NPCL) is related to their steadily increasing incidence, high recurrence rates, delayed diagnosis, and potential complications. In general, hepatic cysts (HCs) are classified into several types, including simple and complex, false and true. Simple cysts are mainly congenital but also occur in polycystic liver disease. Complex cysts include mucinous neoplasms, echinococcal cysts, hemorrhagic cysts, cystic hepatocellular carcinoma, and other rare lesions. Nonparasitic cystic liver lesions do not usually cause symptoms, and their characteristics are not specific. In 15% of cases, nonspecific signs (flatulence, nausea, dyspepsia) accompany pain. Diagnosis of NPCL is based on data from ultrasound, CT, or MRI of the abdominal organs. There still needs to be a consensus on surgical treatment indications or the effectiveness and feasibility of its various methods. Many surgical interventions for NPCL treatment include puncture drainage, multiple minimally invasive (laparoscopic) surgery options, and open methods. In clinical practice, laparoscopic fenestration, associated with fewer complications and faster recovery, has become widespread. However, significant progress has yet to be achieved in reducing NPCL recurrence rates despite advances in surgical treatment. Therefore, multiple studies are underway to improve treatment options for this medical condition. Keywords: Liver, cyst, nonparasitic cyst, pseudocyst, laparoscopic fenestration.
方法:非寄生虫性肝囊肿(NPCL)的相关性与发病率稳步上升、复发率高、诊断延迟和潜在并发症有关。一般情况下,肝囊肿分为简单型和复杂型、假型和真型。单纯性囊肿主要是先天性的,但也见于多囊性肝病。复杂囊肿包括黏液性肿瘤、棘球蚴囊肿、出血性囊肿、囊性肝细胞癌和其他罕见病变。非寄生虫性囊性肝病变通常不引起症状,其特征也不特异性。在15%的病例中,非特异性症状(胀气、恶心、消化不良)伴随疼痛。NPCL的诊断是基于腹部器官的超声、CT或MRI数据。手术治疗指征或其各种方法的有效性和可行性仍需达成共识。NPCL治疗的许多外科干预措施包括穿刺引流,多种微创(腹腔镜)手术选择和开放方法。在临床实践中,腹腔镜开窗术因并发症少、恢复快而得到广泛应用。然而,尽管手术治疗取得了进展,但在降低NPCL复发率方面仍未取得重大进展。因此,多项研究正在进行中,以改善这种疾病的治疗选择。关键词:肝脏,囊肿,非寄生囊肿,假性囊肿,腹腔镜开窗。
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引用次数: 0
INDUCTION OF LABOR IN PRE-ECLAMPTIC WOMEN 先兆子痫妇女的引产
Pub Date : 2023-01-01 DOI: 10.25005/2074-0581-2023-25-3-380-389
M.YA. KAMILOVA, B.K. KOIMDODOVA, F.R. ISHAN-KHODZHAEVA, M. KIYOMIDDINZODA
Objective: The article presents a literature review on the current possibilities of induction of labor (IOL) in severe preeclampsia (SPE). Delivery is the only treatment for preeclampsia (PE), a serious pregnancy complication. In women with SPE, better maternal and perinatal outcomes are associated with vaginal delivery. The exceptions are cases where there are obstetric indications for cesarean section (CS) or the need for urgent delivery due to complications of PE. The optimal IOL methods for women with SPE, especially when early delivery is necessary, are still not established. In this regard, studies on the most appropriate IOL methods for women with PE are crucial. A literature data search was conducted through Elibrary, Cyberleninka, and PubMed to obtain relevant information from the abovementioned databases. Keywords: Pregnancy, severe preeclampsia, labor induction, methods of labor induction.
目的:对目前重度子痫前期(SPE)引产(IOL)的可行性进行文献综述。分娩是治疗子痫前期(PE)的唯一方法,这是一种严重的妊娠并发症。在患有SPE的妇女中,阴道分娩与更好的产妇和围产期结局有关。例外情况是有产科指征的剖宫产(CS)或由于PE并发症需要紧急分娩的情况。SPE妇女的最佳人工晶状体方法,特别是在需要早期分娩的情况下,仍未确定。在这方面,研究最适合PE女性的人工晶状体方法至关重要。通过library、Cyberleninka和PubMed进行文献数据检索,从上述数据库中获取相关信息。关键词:妊娠,重度先兆子痫,引产,引产方法
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引用次数: 0
EMERGENCY CESAREAN SECTION WITH REDO MITRAL VALVE REPLACEMENT FOR ACUTE PROSTHETIC VALVE DYSFUNCTION: A CASE REPORT 急诊剖宫产合并重做二尖瓣置换术治疗急性人工瓣膜功能障碍1例报告
Pub Date : 2023-01-01 DOI: 10.25005/2074-0581-2023-25-3-441-447
I. KHOLOD, E. BUHMAN, S. GRISARU-GRANOVSKY, T. AVITAN, S. TAGER, A. NIR, A. TVITO, Y. GOZAL, A. IOSCOVICH
Department of Anesthesiology, Perioperative Medicine and Pain Treatment, Shaare Zedek Medical Center, affiliated with Hebrew University, Jerusalem, Israel
以色列耶路撒冷希伯来大学附属Shaare Zedek医学中心麻醉科、围手术期医学和疼痛治疗科
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引用次数: 0
STENT IMPLANTATION IN AN ADULT WITH COARCTATION OF THE AORTA: A CASE REPORT 成人主动脉缩窄支架植入术一例报告
Pub Date : 2023-01-01 DOI: 10.25005/2074-0581-2023-25-3-424-430
S.A. ANNANIYAZOVA, B.A. KADYROV, M.D. SEITMUKHAMEDOV, B.A. SHIKHNAZAROVA, P.P. GAIPDZHANOV, A.D. AGANIYAZOV
Objective: Treatment of coarctation of the aorta (CoA) patients remains an unresolved aspect of cardiac surgery. There are two groups of patients with this congenital heart defect (CHD). One group includes newborns who have juvenile CoA and other CHDs. Organs below the CoA area rely on a functioning patent ductus arteriosus for blood supply. Another group of adult patients with an isolated form of CoA primarily consists of teenagers and young males accidentally diagnosed with arterial hypertension. Treatment of patients until the early 1990s was only surgical; now, most undergo endovascular interventions. This case report describes a successful CoA stenting procedure performed on an adult patient at our center.
目的:主动脉缩窄(CoA)患者的治疗仍然是心脏外科未解决的问题。这种先天性心脏缺陷(CHD)有两组患者。一组包括患有幼年CoA和其他冠心病的新生儿。CoA区以下的器官依靠功能正常的动脉导管未闭供血。另一组患有分离型CoA的成年患者主要由意外诊断为动脉高血压的青少年和年轻男性组成。直到20世纪90年代初,对患者的治疗还只是手术;现在,大多数接受血管内介入治疗。本病例报告描述了一个成功的CoA支架手术在我们中心进行的成人患者。
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引用次数: 0
EPIDEMIOLOGICAL ASPECTS OF PERTUSSIS IN CHILDREN 儿童百日咳的流行病学方面
Pub Date : 2023-01-01 DOI: 10.25005/2074-0581-2023-25-3-414-423
A.E. MASLYANINOVA, T.S. RADCHENKO, R.S. ARAKELYAN, A.R. KURBANGALIEVA
Objective: To analyze the epidemiological aspects of pertussis (whooping cough) in the Astrakhan region among children in the period from 2020 to 2022. Methods: During the observation period, 33 children’s outpatient medical records between 2020 and 2022 from various medical institutions in the Astrakhan region were analyzed. Results: Whooping cough affected children of different ages but was more common in infants (younger than 1 year): 46% (n=15), slightly less common in toddlers and preschoolers (1 to 6 years of age): 42% (n=14), while the rate of school-aged children was the lowest: 12% (n=4). In the Astrakhan region, contrary to the city of Astrakhan, the rate of cases under one year of age was higher: 62% (n=6); followed by children 1 to 6 years of age: 25% (n=2), with rarer cases in the school-aged group: 13% (n=1). Among the examined cases the following symptoms prevailed: spasmodic cough (100%; n=33), weakness (94%; n=31), and nasal congestion (58%; n=19), which are typical for the classic course of whooping cough. An extremely rare symptom among children was tonic-clonic seizures: 6% (n=2). No cases of whooping cough with atypical courses have been recorded in the Astrakhan region. Conclusion: Over the past few years, the epidemiological situation with whooping cough infection among the population of the Astrakhan region tended to improve. Susceptibility to whooping cough was characteristic of all ages, but most often children under one year of age were affected. The clinical course was dominated by classical manifestations of pertussis: spasmodic cough, weakness, and nasal congestion. Important diagnostic criteria were the presence of posttussive vomiting and the absence of fever. The main reason for infection among children was non-vaccination due to various medical circumstances or parental refusal. Keywords: Whooping cough, children, vaccination, vaccination calendar, morbidity.
目的:分析2020 - 2022年阿斯特拉罕地区儿童百日咳流行病学情况。方法:在观察期内,对阿斯特拉罕地区各医疗机构2020 - 2022年的33例儿童门诊病历进行分析。结果:百日咳发生在不同年龄的儿童中,但以1岁以下的婴儿多见:46% (n=15),幼儿和学龄前儿童(1 ~ 6岁)少见:42% (n=14),学龄儿童发病率最低:12% (n=4)。在阿斯特拉罕地区,与阿斯特拉罕市相反,一岁以下的病例率更高:62% (n=6);其次是1至6岁儿童:25% (n=2),学龄组病例较少:13% (n=1)。在检查的病例中,主要出现以下症状:痉挛性咳嗽(100%;N =33),虚弱(94%;N =31),鼻塞(58%;N =19),这是典型的百日咳经典病程。儿童中极为罕见的症状是强直阵挛性发作:6% (n=2)。在阿斯特拉罕地区没有记录非典型病程的百日咳病例。结论:近年来,阿斯特拉罕地区人群中百日咳感染的流行病学情况有改善的趋势。百日咳易感性是所有年龄段的特征,但最常见的是一岁以下的儿童受到影响。临床过程以百日咳的典型表现为主:痉挛性咳嗽、虚弱和鼻塞。重要的诊断标准是有无咳后呕吐和无发热。儿童感染的主要原因是由于各种医疗情况或父母拒绝接种疫苗。关键词:百日咳,儿童,疫苗接种,接种日历,发病率。
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引用次数: 0
COMPREHENSIVE ANALYSIS OF THE AORTIC ARCH BRANCHING PATTERNS BASED ON DIAGNOSTIC STUDIES, SURGICAL PROCEDURES, AND AUTOPSY REPORTS 基于诊断研究、外科手术和尸检报告的主动脉弓分支模式的综合分析
Pub Date : 2023-01-01 DOI: 10.25005/2074-0581-2023-25-3-400-413
O.V. MURASHO
Objective: : Analysis of literature sources on variant anatomy of arteries arising from aortic arch and branches. Methods: Analysis of cases of the variant anatomy of arteries arising from the aortic arch (AA) and their branches, based on autopsy, surgery, and modern diagnostic techniques. To gather information, we utilized a range of online resources such as https://www.library.ru, https://www.scopus. com, https://femb.ru/, https://www.cochranelibrary.com/, http://www.acponline.com, https://www.sciencedirect.com/, https://www.embase.com, and the Yandex search engine. The primary research methods utilized were bibliographic and comparative in nature. Conclusion: The AA anatomy displays frequent variations in medical practice. To prevent complications and errors, it is imperative to thoroughly evaluate the patient before performing angiography, surgery, or any relevant medical procedures. Keywords: Aortic arch, branches of the aortic arch, brachiocephalic trunk, variant anatomy, variation.
目的:分析主动脉弓及主动脉弓支动脉变异解剖的文献来源。方法:结合尸检、外科手术和现代诊断技术,对主动脉弓及其分支产生的动脉变异解剖病例进行分析。为了收集信息,我们利用了一系列的在线资源,如https://www.library.ru, https://www.scopus。.com、https://femb.ru/、https://www.cochranelibrary.com/、http://www.acponline.com、https://www.sciencedirect.com/、https://www.embase.com和Yandex搜索引擎。主要的研究方法是书目法和比较法。结论:在医学实践中,腹侧动脉解剖结构变化频繁。为了防止并发症和错误,在进行血管造影、手术或任何相关的医疗程序之前,彻底评估患者是必要的。关键词:主动脉弓,主动脉弓分支,头臂干,变异解剖,变异
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引用次数: 0
PREVALENCE OF CORONARY ARTERY DISEASE IN YOUNG AND MIDDLE AGE PATIENTS WITH RESISTANT ARTERIAL HYPERTENSION 中青年顽固性高血压患者冠状动脉疾病的患病率
Pub Date : 2022-01-01 DOI: 10.25005/2074-0581-2022-24-3-317-323
KH.YO. Sharipova, D. Rakhimov, R. Sokhibov, R. Gulova, D. Kosimova
Objective: To establish the frequency of different forms of coronary artery disease (CAD) in patients with resistant arterial hypertension (AH). Methods: Based on the data from clinical and anamnestic studies and the results of electrocardiography (ECG), Holter ECG monitoring (HM-ECG), and bicycle ergometry (VEM), 370 young and middle-aged patients (WHO, 1965), the mean age 54.1±4, with primary AH were diagnosed with CAD according to the Canadian classification (World Health Organization (WHO), 1979; with additions by All-Union Cardiology Research Centre, 1995). With daily monitoring of blood pressure (BP) against the background of antihypertensive therapy (AHT), groups of patients with controlled (CAH; n=84) and resistant (RAH; n=286) arterial hypertension were identified. Results: It was found that in young and middle-aged patients with both CAH and RAH, the frequency of stable angina pectoris (SA) was the highest, mainly due to functional classes (FC) I-II; severe functional classes of SA, and unstable angina (UA) were markedly less frequent; less than a quarter of patients had a myocardial infarction (MI), mainly due to non-Q-wave MI (non-Q-MI). In patients with CAH and RAH FC I-II of SA were predominant (in 70.2% of patients with CAH and 34.3% with RAH; p=0.0001), while FC III-IV of SA were mainly observed against the background of RAH (21% vs. 5% in patients with CAH, p=0.0015). In patients of young and middle age, against the background of RAH, the frequency of UA (18.9%; p=0.0220) and the total number of MI (25.9%; p=0.0482) was higher, than in CAH, mainly due to Q-MI (11.2%; p=0.0360), indicating the severity of coronary insufficiency. The increase in non-Q-MI against the background of RAH was statistically insignificant (p=0.5191). Conclusion: The ratio of the frequency of different forms of CAD against the background of CAH and RAH was unidirectional. However, the overall frequency of severe forms of CAD (UA and MI, especially Q-MI) in patients with RAH significantly exceeded those in patients with CAH, which allowed us to consider RAH as a factor in the progressive course of CAD. Keywords: Coronary artery disease, stable angina, unstable angina, myocardial infarction, resistant arterial hypertension, young and middle age.
目的:了解顽固性动脉性高血压(AH)患者不同形式冠心病(CAD)的发生频率。方法:根据临床和记忆研究资料,结合心电图(ECG)、动态心电图(HM-ECG)和自行车几何测量(VEM)结果,根据加拿大分类(WHO, 1979)诊断原发性AH的中青年冠心病患者370例(WHO, 1965),平均年龄54.1±4岁;全联合心脏病学研究中心,1995年增编)。在抗高血压治疗(AHT)的背景下,每日监测血压(BP),控制(CAH)患者组;n=84)和耐药(RAH;286例动脉性高血压。结果:在中青年CAH和RAH患者中,稳定性心绞痛(SA)发生率最高,主要是由于功能分级(FC) I-II;严重功能级SA和不稳定型心绞痛(UA)发生率明显降低;不到四分之一的患者发生心肌梗死(MI),主要是由于非q波心肌梗死(non-Q-MI)。在CAH和RAH患者中,FC I-II型SA占主导地位(CAH患者占70.2%,RAH患者占34.3%;p=0.0001),而SA的FC III-IV主要在RAH背景下观察(21% vs. CAH患者的5%,p=0.0015)。在中青年患者中,在RAH背景下,UA的发生率(18.9%;p=0.0220)和MI总数(25.9%;p=0.0482)高于CAH,主要是由于Q-MI (11.2%;P =0.0360),说明冠状动脉功能不全的严重程度。RAH背景下非q - mi的增加无统计学意义(p=0.5191)。结论:CAH和RAH背景下不同形式CAD的频率之比是单向的。然而,RAH患者发生严重形式CAD (UA和MI,特别是Q-MI)的总体频率明显高于CAH患者,这使我们可以考虑RAH是CAD进展过程中的一个因素。关键词:冠心病,稳定型心绞痛,不稳定型心绞痛,心肌梗死,顽固性高血压,中青年。
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引用次数: 0
THE DIAGNOSTIC CHALLENGES PRESENTED BY PATIENT WITH DUPLICATION OF GALLBLADDER WITH THE DISTAL COMMON BILE DUCT STRICTURE 双胆囊伴胆总管远端狭窄患者的诊断挑战
Pub Date : 2022-01-01 DOI: 10.25005/2074-0581-2022-24-1-140-146
A. M. Sharipov, Khizmatullah A. Shamszoda, S. A. Mazabshoev, U. L. Umarov
Objective: Gallbladder duplication is a congenital malformation, is rarely recognized in childhood and occurs in 1 in 4,000 live births. Often, abnormalities in the development of the biliary tract are detected on abdominal imaging or accidentally during surgery in adult patients for an unrelated condition. In this article, the authors describe the complexity of diagnosing a combination of duplication of the gallbladder and stricture of the common bile duct in a 14-year-old child and analyze the diagnostic and tactical errors in the surgical treatment that resulted in the failure to timely diagnose the stricture of the common bile duct. In our opinion, timely diagnosis and proper surgical technique in combined hepatobiliary disorders in children are difficult, even for experienced professionals. However, adequate clinical manifestations assessment, considering an alternative explanation for the presenting symptoms, and timely correction of management errors in the preoperative period could lead to better treatment outcomes. Keywords: Hepatobiliary system, congenital anomalies, gallbladder duplication, stricture of the common bile duct, pediatric.
目的:胆囊重复是一种先天性畸形,在儿童时期很少被发现,每4000个活产儿中就有1个发生。通常,胆道发育的异常是在腹部成像中发现的,或者是在成人患者因不相关疾病的手术中意外发现的。在这篇文章中,作者描述了一个14岁的儿童胆囊重复和胆总管狭窄合并诊断的复杂性,并分析了手术治疗中导致胆总管狭窄未能及时诊断的诊断和策略错误。在我们看来,及时诊断和正确的手术技术对儿童肝胆联合疾病是困难的,即使是经验丰富的专业人员。然而,充分的临床表现评估,考虑到出现症状的另一种解释,并及时纠正术前管理错误,可能会导致更好的治疗结果。关键词:肝胆系统,先天性畸形,胆囊复制,胆总管狭窄,儿童
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引用次数: 0
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Paemi Sino
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