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Predictors of Seven-Day Mortality in Patients with Advanced Oncologic Liver Disease Admitted to a Palliative Care Unit 姑息治疗病房住院的晚期肿瘤性肝病患者7天死亡率的预测因素
Pub Date : 2018-01-01 DOI: 10.4172/2165-7386.1000339
N. Rahm, Audrey Calmant, C. Combescure
Context and objectives: A specific prognostic tool is lacking for end-stage oncological liver diseases. In addition to various factors, bilirubin, which reflects the severity of liver dysfunction, may be associated with mortality in this population. We aimed to assess how bilirubin influence survival in patients admitted in palliative care units with advanced oncologic liver diseases and to develop a prognostic model combining bilirubin with other factors. Methods: Data were collected retrospectively from 652 patients with oncologic liver diseases, accounting for 25% of all admissions in our palliative care units from 2011 to 2016. Age, gender, chronic liver diseases, infections including spontaneous bacterial peritonitis, gastrointestinal bleeding, encephalopathy, Eastern Cooperative Oncology Group score (ECOG), oral intake, jaundice, dyspnea, bilirubin, albumin and urea variables collected within 24 hours before or after admission were analyzed. Univariate and multivariate survival analyses were performed to identify the predictive value of bilirubin and other variables for 7-day survival. Results: Bilirubin value was collected in 398 patients. Univariate analysis showed that male sex, chronic liver diseases, encephalopathy, ECOG, oral intake, jaundice, bilirubin and urea blood levels, were associated with 7-day survival. Multivariate analysis showed that bilirubin>25 μ mol/L, urea>15 mmol/L, ECOG=4 and reduced oral intake, were independently correlated with survival. Accuracy of the model based on these factors to predict 7-day mortality is high (AUC=0.90). Conclusion: Bilirubin is an independent prognostic factor for 7 day-survival among patients with end-stage oncologic liver disease. Combining bilirubin, urea, ECOG and oral intake increases short term prognostication accuracy in this subgroup of patients.
背景和目的:缺乏终末期肿瘤性肝病的特异性预后工具。除了各种因素外,反映肝功能障碍严重程度的胆红素可能与这一人群的死亡率有关。我们的目的是评估胆红素如何影响姑息治疗病房住院的晚期肿瘤性肝病患者的生存,并建立胆红素与其他因素结合的预后模型。方法:回顾性收集2011年至2016年652例肿瘤性肝病患者的资料,占我院姑息治疗部门所有入院患者的25%。分析年龄、性别、慢性肝病、感染(包括自发性细菌性腹膜炎、胃肠道出血、脑病)、东部肿瘤合作组评分(ECOG)、入院前后24小时内的口服摄入、黄疸、呼吸困难、胆红素、白蛋白、尿素等变量。进行单因素和多因素生存分析,以确定胆红素和其他变量对7天生存的预测价值。结果:收集了398例患者的胆红素值。单因素分析显示,男性、慢性肝病、脑病、ECOG、口服摄入量、黄疸、胆红素和尿素血水平与7天生存率相关。多因素分析显示,胆红素>25 μ mol/L、尿素>15 mmol/L、ECOG=4、口服摄入量减少与生存率独立相关。基于这些因素的模型预测7天死亡率的准确性很高(AUC=0.90)。结论:胆红素是终末期肿瘤性肝病患者7天生存率的独立预后因素。联合胆红素、尿素、ECOG和口服摄入可提高该亚组患者的短期预后准确性。
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引用次数: 0
Challenging Pain Management in Widespread Metastatic Neuroendocrine Tumour 广泛转移性神经内分泌肿瘤疼痛管理的挑战
Pub Date : 2018-01-01 DOI: 10.4172/2165-7386.1000341
S. Majeed, N. Rodwell
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引用次数: 0
“Do-Not-Resuscitate” Orders in Children with Cancer at the End of Life: A Retrospective Review “不复苏”命令的儿童癌症在生命的尽头:回顾性审查
Pub Date : 2018-01-01 DOI: 10.4172/2165-7386.1000340
Chun-Chu Chang, M. Lee, Yu‐Chuan Wen, Tingting Yu, Shih-Hsiang Chen, T. Jaing
‘‘Do-not-resuscitate’’ (DNR) orders constitute a vital part of End-of-Life (EOL) care for patients with terminal cancer. In this retrospective study, we reviewed the medical records of patients treated at a tertiary referral pediatric oncology unit between May 2006 and May 2017. We gathered data about days from signing the DNR to death, age at death, gender, disease and its status, place of death, and survival and performed t-test and χ2 test as appropriate. Of the 225 patients [127 males, 98 females; median age: 10.0 years (range, 0.4-23.4) years] enrolled, 130 (57.8%) provided DNR orders signed by their surrogates. In addition, 29.3%, 44.8%, and 25.8% of deaths occurred in the pediatric oncology ward, the intensive care unit, and at home or another hospital, respectively. We observed an annual increase in the signing rate of DNR orders. The median duration between signing a DNR order and death was 2 (range: 0-88) days. Furthermore, DNR orders tended to be committed by patients with slowly deteriorating disease and those with extended overall survival. This study deduces that an explicit DNR order is now a rule rather than an exception, with more DNR orders being signed for patients aged>10 years hospitalized for EOL cancer care. Hence, the early implementation of a DNR order could be underutilized in younger patients with cancer.
“不复苏”(DNR)指令是晚期癌症患者生命终结(EOL)护理的重要组成部分。在这项回顾性研究中,我们回顾了2006年5月至2017年5月期间在三级转诊儿科肿瘤科治疗的患者的医疗记录。收集患者从签署DNR到死亡的天数、死亡年龄、性别、疾病及其状态、死亡地点、生存期等数据,并酌情进行t检验和χ2检验。225例患者中,男性127例,女性98例;中位年龄:10.0岁(范围0.4-23.4)岁),130例(57.8%)提供由其代理人签署的DNR订单。此外,29.3%、44.8%和25.8%的死亡分别发生在儿科肿瘤病房、重症监护病房和家中或其他医院。我们观察到DNR订单的签署率每年都在增加。从签署DNR命令到死亡的中位持续时间为2天(范围:0-88天)。此外,病情缓慢恶化的患者和总生存期延长的患者往往会执行DNR命令。本研究推断,明确的不抢救命令现在是一种规则,而不是例外,越来越多的年龄在10岁至10岁之间的患者签署了不抢救命令,以接受EOL癌症治疗。因此,在年轻的癌症患者中,早期实施DNR命令可能没有得到充分利用。
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引用次数: 0
Access to Palliative Care Services: A Qualitative Study of Experiences of Children and Families Attending University Teaching Hospital in Lusaka 缓和疗护服务的可及性:卢萨卡大学教学医院儿童及家庭住院经验的质性研究
Pub Date : 2018-01-01 DOI: 10.4172/2165-7386.1000328
W. Mutale, F. Goma, L. Gwyther
Introduction: WHO recommends provision of palliative care for all who need it according to needs and context. However, in Sub-Saharan Africa coverage of palliative care services remain low especially children. This study reports experiences of palliative care services for children and their families attending the University Teaching hospital in Lusaka, Zambia. Methodology: The was a cross-sectional qualitative study conducted at University teaching hospital in Lusaka, Zambia. Results: The major challenges faced by families included lack of economic/financial and bereavement support. Most families were referred to the UTH from very far places without any form of support. One major barrier identified to provision of palliative care was poor coordination of services with most patients missing out on services which were already available. While social workers were available, poor funding negatively affected this service. There were very few trained health workers in palliative care. Pain management remained poor with many clinicians still not comfortable to prescribe stronger analgesia such as morphine for severe pain. Conclusion: The study revealed significant gaps for children’s palliative care services in at the University teaching hospital in Zambia. One major barrier identified to provision of palliative care was poor coordination of services. Families reported lack of economic and bereavement support in addition to lack of information.
导言:世卫组织建议根据需要和情况向所有需要的人提供姑息治疗。然而,在撒哈拉以南非洲,姑息治疗服务的覆盖率仍然很低,尤其是儿童。本研究报告了在赞比亚卢萨卡大学教学医院为儿童及其家庭提供姑息治疗服务的经验。方法:本研究是在赞比亚卢萨卡大学教学医院进行的横断面定性研究。结果:家庭面临的主要挑战包括缺乏经济/财政支持和丧亲支持。大多数家庭都是在没有任何支持的情况下从很远的地方转介到综合医院的。确定的提供姑息治疗的一个主要障碍是服务协调不力,大多数患者错过了已经提供的服务。虽然有社会工作者,但资金不足对这项服务产生了负面影响。在缓和治疗方面训练有素的保健工作者很少。疼痛管理仍然很差,许多临床医生仍然不愿意开更强的镇痛药,如吗啡对严重的疼痛。结论:该研究揭示了在赞比亚大学教学医院儿童姑息治疗服务的显著差距。确定的提供姑息治疗的一个主要障碍是服务协调不力。家庭报告说,除了缺乏信息外,还缺乏经济和丧亲支持。
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引用次数: 0
Physician Assisted Suicide for Terminally Ill Patients: An Argumentative Essay 医生协助临终病人自杀:一篇议论文
Pub Date : 2018-01-01 DOI: 10.4172/2165-7386.1000337
A. Ababneh
Dying process is too often needlessly protracted by these medical technology is consequently marked by incapacitations, intolerable pain, and indignity. Physician assisted suicide defines as knowingly and intentionally providing a person with the knowledge or means or both required to commit suicide, including counseling about lethal doses of drugs, prescribing such lethal doses or supplying the drugs. Therefore, the aim of this paper is to create an argumentative essay to argue the use of physician assisted suicide for terminally ill patients as a last resort to end their suffer and end their life, while taking the legal and ethical points of view of opponents and proponents into consideration.
由于这些医疗技术,死亡过程往往被不必要地延长,结果是丧失能力、无法忍受的痛苦和侮辱。医生协助自杀的定义是,在知情的情况下,有意地向一个人提供自杀所需的知识或手段,包括关于致命剂量药物的咨询,开致命剂量的处方或提供药物。因此,本文的目的是创建一个议论文来争论使用医生协助自杀的绝症患者作为最后的手段来结束他们的痛苦和结束他们的生命,同时考虑到反对者和支持者的法律和伦理观点。
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引用次数: 0
Knowledge and Attitude of ER and ICU Physicians towards DNR in a Tertiary Care Center in Saudi Arabia: A Survey Study 沙特阿拉伯三级医疗中心急诊室和ICU医生对DNR的知识和态度:一项调查研究
Pub Date : 2018-01-01 DOI: 10.4172/2165-7386.1000327
Alaa M. Gouda, N. Alrasheed, Alaa Ali, Ahmad Allaf, Najd Almudaiheem, Youssuf Ali, A. Alghabban, Sami Alsalolami
Introduction: Only a few studies from Arab Muslim countries address DNR practice. Our institute has a clear DNR policy. The knowledge of the existing policy and the attitude towards DNR of emergency room (ER) and intensive care unit (ICU) physicians were studied through this survey. Objective: To identify the knowledge of the participants of the local DNR policy and guidelines and to summarize the possible barriers of addressing DNR including religious background. Method: A questionnaire has been distributed to ER and ICU physicians. The answers to the questions were tabulated and analyzed using frequencies and percentage. Results: Total of 112 physicians with majority (97.3%) are from a Muslim religion. Among the participants 108 (96.4%) were aware about the existence of DNR policy in our institute. 107 (95.5%) stated that DNR is not against Islamic rules. Only (13.4%) of the physicians have advance directives and (90.2%) answered they will request to be placed as DNR if they have terminal illness. Lack of patients and families understanding (51.8%) and inadequate training (35.7%) were the 2 most important barriers for effective DNR discussion. Patients and Families level of education (58.0%) and cultural factors (52.7%) were the main obstacles in initiating a DNR order. Only (1.8%) of the participants stated that DNR is against their religious belief. Conclusions: There is a lack of knowledge about DNR policy which make the optimization of DNR process difficult. Most physicians wish DNR for themselves and their patients at end of life but only a few of them have advance directives. The most important barriers for initializing and discussing DNR were lack of patient understanding, level of education, and the culture of patients. Most of the Muslim physicians believe that DNR is not against Islamic rules. We suggest that the DNR concept should be part of any training program.
引言:只有少数阿拉伯穆斯林国家的研究涉及DNR实践。我们学院有明确的DNR政策。通过本次调查,研究了急诊室(ER)和重症监护病房(ICU)医生对现行政策的了解程度和对DNR的态度。目的:确定参与者对当地DNR政策和指导方针的了解程度,并总结处理DNR的可能障碍,包括宗教背景。方法:对急诊和ICU医师进行问卷调查。问题的答案被制成表格,并使用频率和百分比进行分析。结果:共有112名医生,其中穆斯林居多(97.3%)。参与者中108人(96.4%)了解我院存在DNR政策。107人(95.5%)表示DNR不违反伊斯兰教规。只有(13.4%)的医生有预先指示,(90.2%)的医生回答说,如果他们有绝症,他们会要求将他们列为无抢救病人。缺乏患者和家属的理解(51.8%)和培训不足(35.7%)是有效讨论DNR的两个最重要的障碍。患者及家属的文化程度(58.0%)和文化因素(52.7%)是患者启动DNR的主要障碍。只有(1.8%)的参与者表示DNR违背了他们的宗教信仰。结论:由于缺乏对DNR政策的了解,使得DNR流程的优化变得困难。大多数医生都希望他们自己和他们的病人在生命结束时都能接受“无药抢救”,但只有少数医生有预先指示。初始化和讨论DNR的最重要障碍是缺乏患者理解,教育水平和患者文化。大多数穆斯林医生认为,DNR并不违反伊斯兰教规。我们建议DNR概念应该成为任何培训计划的一部分。
{"title":"Knowledge and Attitude of ER and ICU Physicians towards DNR in a Tertiary Care Center in Saudi Arabia: A Survey Study","authors":"Alaa M. Gouda, N. Alrasheed, Alaa Ali, Ahmad Allaf, Najd Almudaiheem, Youssuf Ali, A. Alghabban, Sami Alsalolami","doi":"10.4172/2165-7386.1000327","DOIUrl":"https://doi.org/10.4172/2165-7386.1000327","url":null,"abstract":"Introduction: Only a few studies from Arab Muslim countries address DNR practice. Our institute has a clear DNR policy. The knowledge of the existing policy and the attitude towards DNR of emergency room (ER) and intensive care unit (ICU) physicians were studied through this survey. Objective: To identify the knowledge of the participants of the local DNR policy and guidelines and to summarize the possible barriers of addressing DNR including religious background. Method: A questionnaire has been distributed to ER and ICU physicians. The answers to the questions were tabulated and analyzed using frequencies and percentage. Results: Total of 112 physicians with majority (97.3%) are from a Muslim religion. Among the participants 108 (96.4%) were aware about the existence of DNR policy in our institute. 107 (95.5%) stated that DNR is not against Islamic rules. Only (13.4%) of the physicians have advance directives and (90.2%) answered they will request to be placed as DNR if they have terminal illness. Lack of patients and families understanding (51.8%) and inadequate training (35.7%) were the 2 most important barriers for effective DNR discussion. Patients and Families level of education (58.0%) and cultural factors (52.7%) were the main obstacles in initiating a DNR order. Only (1.8%) of the participants stated that DNR is against their religious belief. Conclusions: There is a lack of knowledge about DNR policy which make the optimization of DNR process difficult. Most physicians wish DNR for themselves and their patients at end of life but only a few of them have advance directives. The most important barriers for initializing and discussing DNR were lack of patient understanding, level of education, and the culture of patients. Most of the Muslim physicians believe that DNR is not against Islamic rules. We suggest that the DNR concept should be part of any training program.","PeriodicalId":91127,"journal":{"name":"Journal of palliative care & medicine","volume":"8 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2165-7386.1000327","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70684034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Existential Analysis and Logo Therapy on a Good Way to Die “好死”的存在分析与标志疗法
Pub Date : 2018-01-01 DOI: 10.4172/2165-7386.1000330
M. Ulrichová
Dying and death is often understood as an ungraspable process, which is connected with a pain perception, fear and people do not like talking about this topic. We also face with this issue in the Czech Republic; often it is a taboo process. Logo therapy and existential analyses offers another point of view at this phenomenon, logo therapy perceives life as the only one that is meaningful, that has its clear boarders. And by allowing this existence of these limits it gives man everyday meaningful content, experience it intensively and to communicate immediately about its end, which is absolutely natural to life and inherently belongs. Only then, when we accept death as something given and unavoidable, we can help our loved ones who are in terminal phases and to allow them a peaceful leaving from their lives. Palliative medicine plays a great role in many dying men, helps men to cope with those situations which are already medical impractical.
死亡和死亡通常被理解为一个无法理解的过程,它与疼痛感知、恐惧和人们不喜欢谈论这个话题有关。我们在捷克共和国也面临这个问题;这通常是一个禁忌的过程。标志疗法和存在主义分析为这一现象提供了另一种观点,标志疗法认为生命是唯一有意义的,有明确界限的。通过允许这些限制的存在,它给予人们日常有意义的内容,深入地体验它,并立即交流它的目的,这对生活来说是绝对自然的,固有的归属。只有这样,当我们接受死亡是必然的和不可避免的,我们才能帮助那些处于临终阶段的亲人,让他们平静地离开他们的生活。缓和医学在许多垂死的人身上发挥了巨大的作用,帮助人们应对那些在医学上已经不切实际的情况。
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引用次数: 0
Blood Pressure Levels and Urinary Frequency in Hypertensive Patients: A Cross-sectional Analysis 高血压患者血压水平和尿频:一项横断面分析
Pub Date : 2018-01-01 DOI: 10.4172/2165-7386.1000345
M. Sarfraz, Sana Shaikh, S. A. Zaidi, A. Raees, Ahsan Ali Siddiqui, N. Jamil, A. Anwar
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引用次数: 0
Palliative Care is a Useful Means to Overcome Intercultural Barriers Faced by Refugees in their New Host Countries 姑息治疗是难民在新东道国克服跨文化障碍的有效手段
Pub Date : 2018-01-01 DOI: 10.4172/2165-7386.1000334
M. Silbermann, L. Baider, D. Respini, P. Tralongo, M. Daher, Rana F. Obeidat, N. Gafer, S. Fadhil, M. Rassouli, S. Cheli, A. Eniu, L. Balducci
The unprecedented wave of refugee migration from Africa and the Middle East to Europe presents major challenges to European health professionals and to society at large. A recent workshop which took place in Syracuse, Sicily, brought together physicians, nurses and psychologists and managers of governmental agencies from Italy, Lebanon, Israel, Iraq, Iran, Sudan, Tunisia, Jordan, and the European Society of Medical Oncology, aimed to create a training program to formulate a dialogue between professionals in their regions and refugees in Italy. A major barrier refugees face is a lack of communication (verbal and cultural) which hinders their smooth absorption into society. Cultural mediators who speak Arabic and Italian and understand the refugees’ faith, tradition and beliefs, are paramount to successfully building bridges between such diversities. Predictably, most asylum seekers undergo anxiety, fear, and depression after arriving in Europe. Following intensive deliberations, all workshop participants agreed that applying palliative care methodologies, as practiced in cancer patients, would be therapeutically advantageous in overcoming the psychological suffering that refugees experience during their initial stay in Europe. Accordingly, all agreed to start with training courses, both in refugees’ countries of origin and in Europe, for representatives or mediators (preferably with some clinical background and experience); whereby tremendous efforts would be made to create a working palliative care model that includes bio-psycho-social elements. This model or paradigm will employ a culturally sensitive approach that takes refugees’ spiritual needs into consideration, relying on core ethical principles.
从非洲和中东到欧洲的前所未有的难民潮给欧洲卫生专业人员和整个社会带来了重大挑战。最近在西西里岛锡拉丘兹举办的一次讲习班汇集了来自意大利、黎巴嫩、以色列、伊拉克、伊朗、苏丹、突尼斯、约旦和欧洲肿瘤医学学会的医生、护士、心理学家和政府机构的管理人员,目的是制定一个培训方案,以便在各自地区的专业人员与意大利的难民之间开展对话。难民面临的一个主要障碍是缺乏交流(语言和文化),这阻碍了他们顺利融入社会。讲阿拉伯语和意大利语并了解难民的信仰、传统和信仰的文化调解人对于成功地在这种多样性之间建立桥梁至关重要。可以预见的是,大多数寻求庇护者在抵达欧洲后都会经历焦虑、恐惧和抑郁。经过深入讨论后,所有讲习班与会者一致认为,在癌症患者身上采用姑息治疗方法,在治疗上有利于克服难民在欧洲最初逗留期间所经历的心理痛苦。因此,所有各方都同意开始在难民原籍国和欧洲为代表或调解人(最好有一些临床背景和经验)举办培训班;为此,我们将付出巨大的努力来创造一种包括生物、心理和社会因素在内的有效的姑息治疗模式。这种模式或范式将采用一种文化敏感的方法,以核心伦理原则为基础,考虑到难民的精神需求。
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引用次数: 0
An Overview of Breast Cancer Epidemiology, Incidence and Trends from 2008-2016 in Dubai Hospital, Dubai Health Authority, Hospital-Based Cancer Registry 2018 迪拜医院2008-2016年乳腺癌流行病学、发病率和趋势综述,迪拜卫生局,2018年医院癌症登记处
Pub Date : 2018-01-01 DOI: 10.4172/2165-7386.1000346
N. Salim, H. Hussain, M. Tuffaha, Raja Kathamuthu, A. Tamimi, Amna Abunawas Al Mehairi
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引用次数: 0
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Journal of palliative care & medicine
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