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Palliative Care and Universal Health Coverage: Don't Leave those Suffering Behind 姑息治疗和全民健康覆盖:不要让那些受苦的人掉队
Pub Date : 2018-01-01 DOI: 10.4172/2165-7386.1000e141
K. Mehta, Rinal Parikh
Palliation is a term that has emerged in modern medicine over the last century. Derived from the Latin word “palliat”, palliation notably masks a person’s pain. The standard definition of palliative care given by WHO (World Health Organization) is “Palliative care is an approach that improves the quality of life of patients and their families facing the problem associated with life-threatening diseases, through the prevention and relief of suffering by means of early identification and impeccable assessment and treatment of pain and other problems, physical, psychosocial and spiritual” [1].
姑息治疗是上个世纪在现代医学中出现的一个术语。palliation源自拉丁语“palliat”,主要用来掩盖一个人的痛苦。世卫组织(世界卫生组织)给出的姑息治疗的标准定义是:“姑息治疗是一种方法,通过早期识别和无懈可击的评估和治疗疼痛和其他身体、社会心理和精神问题,预防和减轻痛苦,从而改善面临与危及生命的疾病有关的问题的病人及其家属的生活质量”。
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引用次数: 0
Palliative Care in Qatar, 2008-2016 卡塔尔的姑息治疗,2008-2016
Pub Date : 2018-01-01 DOI: 10.4172/2165-7386.1000325
T. Bharani, Y. Li, I. Helmy, L. Menon, Arachchige Sm, M. Soliman, Y. Wen, K. Silla, Y. Othman, G. Sadek, A. Bashir, H. Eltahir, Saad Jobran Eziada, A. Allam, A. Hassan
With the increase of geriatric population, there is rise in demand for services aimed at improving end-of-life care. Palliative care, through its five-component approach, focuses on improving the quality of life and provide relief from complications of serious illnesses. Although a widely accepted concept in other parts of the world, palliative care is a relatively new concept in the Middle East, having been initiated in Qatar only in 2008. The paper discusses the development of palliative care program in Qatar from its initiation in 2008 to its development until 2016, and aims to delineate a stepwise approach for establishment of a successful palliative care program elsewhere, especially in the Middle East, through the model used in Qatar. Primary research data was obtained through analysis of patient demographics and interviews, and secondary data was attained through literature review using PubMed, CINAHL and Google Scholar respectively. Through its multi-faceted approach, aligning with the national health strategy, meeting the rising demands of Qatar’s population, involving a multi-disciplinary team, focusing on education and research, palliative care in Qatar has established a successful model. It is the first one in the region to get Joint Commission International accreditation, thus aligning in par with the international standards and is striving to meet the emerging needs of Qatar’s population and uphold its title as a successful model.
随着老年人口的增加,对旨在改善临终关怀的服务的需求也在增加。姑息治疗通过其五部分方法,侧重于改善生活质量和减轻严重疾病的并发症。虽然在世界其他地区,姑息治疗是一个被广泛接受的概念,但在中东地区,姑息治疗是一个相对较新的概念,直到2008年才在卡塔尔启动。本文讨论了卡塔尔姑息治疗计划的发展,从2008年开始到2016年的发展,旨在通过卡塔尔使用的模型,描绘出在其他地方建立成功的姑息治疗计划的逐步方法,特别是在中东。主要研究资料通过患者人口统计学分析和访谈获得,次要资料分别通过PubMed、CINAHL和谷歌Scholar进行文献综述。通过其多方面的做法,与国家卫生战略保持一致,满足卡塔尔人口日益增长的需求,由多学科团队参与,注重教育和研究,卡塔尔的姑息治疗建立了一个成功的模式。它是该地区第一个获得国际联合委员会认证的学校,从而与国际标准保持一致,并努力满足卡塔尔人民的新需求,维护其作为成功典范的称号。
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引用次数: 4
Supervised, Individualized Exercise Programs Help Mitigate Costs during Cancer Treatment 有监督的、个性化的锻炼计划有助于降低癌症治疗期间的费用
Pub Date : 2018-01-01 DOI: 10.4172/2165-7386.1000338
K. Wonders
Background: Cancer and its associated treatments often result in long-term physical and psychological side effects that negatively impact the cancer survivor's quality of life. In addition, the financial costs of cancer are substantial and are projected to reach $158 billion by the year 2020. Research indicates that endurance exercise training is helpful in attenuating the deleterious effects of cancer treatments by increasing survival, attenuating myocardial lesions and myocyte disarray, increasing levels of antioxidants, decreasing lipid peroxidation induced by oxidative stress and markers of apoptosis, and preserving cardiac function. However, nationally less than 5% of patients are ever referred to a cancer rehabilitation exercise program. Cost is a barrier to these programs, as they often are not reimbursable under most insurance plans. Purpose: Therefore, the purpose of this investigation was to determine if exercise training during cancer treatment helped to minimize side effects and reduce health care costs. Specifically, treatment tolerance, length of hospital stay, hospital readmits, ER visits, and treatment compliance were measured. Methods: This was a retrospective, two-group study which ascertained the protective effect of an exercisetraining program during cancer treatment. All oncology patients who received cancer treatment at Kettering Medical Center in Dayton, Ohio between January-December 2016 were identified by office staff. Their medical records were pulled and patients were placed in one of two groups: those who exercised during treatment, and those who remained sedentary. The medical records were reviewed to determine outcome data for length of hospital stays, hospital readmits, ER visits, treatment compliance, fatigue, and anxiety/depression related to oncology conditions. The age range of the patients was 21-93 years. Patients were excluded if they had pre-existing cardiac, liver, and bone marrow conditions prior to treatment. Individuals in the exercise group (EX, n=672) completed 12 weeks of prescribed, individualized exercise that included cardiovascular, strength training, and flexibility components. The intensity level for the cardiovascular exercise ranged from 30%-45% of the individual’s predicted VO2max. The strength training involved a full body workout, with emphasis on all major muscle groups. Individuals in the sedentary group (SED, n=728) did not participate in an exercise program during treatment. Results: Patients in the EX group had significantly lower reports of fatigue, pain, and cardiac problems (p<0.05), as well as fewer notes of depression and anxiety than their SED group counterparts. In addition, the EX group tolerated their treatment significantly better than the SED group (p<0.05). Finally, the EX group had a significantly lower number of ER visits (EX=2, SED=14, p<0.05), 30-day readmits (EX=2, SED=53, p<0.05) as well as a shorter length of stay (EX=0.75, SED=3 p<0.05). Conclusion: Results from
背景:癌症及其相关治疗通常会导致长期的生理和心理副作用,对癌症幸存者的生活质量产生负面影响。此外,癌症的经济成本很高,预计到2020年将达到1580亿美元。研究表明,耐力运动训练有助于减轻癌症治疗的有害影响,通过增加生存率,减轻心肌病变和心肌细胞紊乱,增加抗氧化剂水平,减少氧化应激诱导的脂质过氧化和细胞凋亡标志物,并保持心脏功能。然而,在全国范围内,只有不到5%的患者接受过癌症康复训练计划。费用是这些项目的一个障碍,因为它们在大多数保险计划中通常是不可报销的。目的:因此,本研究的目的是确定在癌症治疗期间运动训练是否有助于减少副作用和降低医疗费用。具体来说,治疗耐受性、住院时间、再次入院、急诊室就诊和治疗依从性被测量。方法:这是一项回顾性的两组研究,以确定运动训练计划在癌症治疗期间的保护作用。2016年1月至12月期间在俄亥俄州代顿市凯特林医疗中心接受癌症治疗的所有肿瘤患者均由办公室工作人员确定。他们的医疗记录被调出,患者被分为两组:一组在治疗期间运动,另一组保持久坐不动。对医疗记录进行审查,以确定与肿瘤相关的住院时间、再次入院、急诊室就诊、治疗依从性、疲劳和焦虑/抑郁的结果数据。患者年龄21 ~ 93岁。如果患者在治疗前已存在心脏、肝脏和骨髓疾病,则排除在外。运动组(EX, n=672)完成了12周的处方个体化运动,包括心血管、力量训练和柔韧性训练。心血管运动的强度水平为个体预测最大摄氧量的30%-45%。力量训练包括全身锻炼,重点是所有主要肌肉群。久坐组(SED, n=728)在治疗期间没有参加锻炼计划。结果:EX组患者的疲劳、疼痛和心脏问题报告明显低于SED组(p<0.05),抑郁和焦虑的记录也少于SED组。此外,EX组对治疗的耐受性明显优于SED组(p<0.05)。最后,EX组急诊次数(EX=2次,SED=14次,p<0.05)、30天再入院次数(EX=2次,SED=53次,p<0.05)和住院时间(EX=0.75, SED=3次,p<0.05)均显著降低。结论:这项调查的结果表明,中等强度的运动具有保护作用,可以减少急诊室就诊次数、30天再入院次数和住院时间,从而为付款人、提供者和患者节省成本。
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引用次数: 4
The effects of aroma therapy on agitation in patients with dementia: A systematic review and meta-analysis 芳香疗法对痴呆患者躁动的影响:一项系统回顾和荟萃分析
Pub Date : 2017-12-07 DOI: 10.4172/2165-7386-C2-018
Heeok Park
Tau protein accumulation is the most common pathology among degenerative brain diseases, including Alzheimer9s disease (AD), progressive supranuclear palsy (PSP), traumatic brain injury (TBI) and over twenty others. Tau-containing neurofibrillary tangle (NFT) accumulation is the closest correlate with cognitive decline and cell loss, yet the mechanisms mediating tau toxicity are poorly understood. NFT-containing neurons do not die, which suggests secondary mechanisms are driving toxicity. We evaluated gene expression patterns of NFT-containing neurons microdissected from AD patient brains and found they develop an expression profile consistent with cellular senescence described in dividing cells. This complex stress response induces a near permanent cell cycle arrest, adaptations to maintain survival, cellular remodeling, and metabolic dysfunction. Moreover, senescent cells induce chronic degeneration of surrounding tissue through the secretion of pro-inflammatory, pro-apoptotic molecules termed the senescence-associated secretory phenotype (SASP). Using transgenic mouse models of tau-associated pathogenesis we found that NFTs induced a senescence-like phenotype including DNA damage, karyomegaly, mitochondrial dysfunction and SASP. Cdkn2a transcript level, a hallmark measure of senescence, directly correlated with brain atrophy and NFT load. This relationship extended to postmortem brain tissue from humans with PSP to indicate a phenomenon common to tau toxicity. Tau transgenic mice with late stage pathology were treated with senolytics to remove senescent cells. Despite the advanced age and disease progression, senolytic treatment reduced total NFT burden, neuron loss and ventricular enlargement; and normalized cerebral blood flow to that of non-transgenic control mice. Collectively, these findings indicate that NFTs induce cellular senescence in the brain, which contributes to neurodegeneration and brain dysfunction. Moreover, given the prevalence of tau protein deposition among neurodegenerative diseases, these findings have broad implications for understanding, and potentially treating, dozens of brain diseases.
Tau蛋白积累是退行性脑疾病中最常见的病理,包括阿尔茨海默病(AD)、进行性核上性麻痹(PSP)、创伤性脑损伤(TBI)等二十多种疾病。含tau的神经原纤维缠结(NFT)积累与认知能力下降和细胞损失密切相关,但介导tau毒性的机制尚不清楚。含有nft的神经元不会死亡,这表明次级机制正在驱动毒性。我们评估了从阿尔茨海默病患者大脑中显微解剖的含有nft的神经元的基因表达模式,发现它们的表达谱与分裂细胞中描述的细胞衰老一致。这种复杂的应激反应诱导了近乎永久性的细胞周期阻滞、维持生存的适应性、细胞重塑和代谢功能障碍。此外,衰老细胞通过分泌促炎、促凋亡分子(称为衰老相关分泌表型(SASP))诱导周围组织的慢性变性。利用tau相关发病机制的转基因小鼠模型,我们发现nft诱导衰老样表型,包括DNA损伤、核肿大、线粒体功能障碍和SASP。Cdkn2a转录水平是衰老的标志,与脑萎缩和NFT负荷直接相关。这种关系延伸到患有PSP的人死后脑组织,表明tau毒性的一种常见现象。用抗衰老药物治疗晚期病理的Tau转基因小鼠,去除衰老细胞。尽管高龄和疾病进展,抗衰老治疗减少了总NFT负担、神经元损失和心室增大;正常的脑血流量与非转基因对照小鼠相同。总的来说,这些发现表明nft诱导大脑细胞衰老,从而导致神经变性和脑功能障碍。此外,鉴于tau蛋白沉积在神经退行性疾病中的普遍存在,这些发现对理解和潜在治疗数十种脑部疾病具有广泛的意义。
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引用次数: 2
Extending Mentoring in Palliative Medicine-Systematic Review on Peer, Near-Peer and Group Mentoring in General Medicine 姑息医学指导的延伸——全科医学同伴、近同伴和团体指导的系统综述
Pub Date : 2017-11-07 DOI: 10.4172/2165-7386.1000323
B. Tan, Ying Li Toh, Y. P. Toh, R. Kanesvaran, L. Krishna
A shortage of trained mentors in Palliative Medicine has inspired efforts to employ near peer, peer and group (NPG) mentoring to supplement traditional novice mentoring or mentoring between senior clinicians and junior doctors and or medical students as a means of ensuring that holistic support is available to mentees in a timely, appropriate and personalised manner. Scrutiny of prevailing data on NPG mentoring however, reveals significant gaps in understanding and practice of NPG mentoring that has precipitated conflation with preceptorship, rolemodeling, sponsorship, supervision and counseling. A failure to consider mentoring's evolving, goal-sensitive, context-specific and relational, mentee, mentor and organizational-dependent process nature has further limited available NPG mentoring research. This review seeks to advance a clinically-relevant understanding of NPG mentoring that will help delineate the practice of NPG mentoring and potentially see it blended with novice mentoring. Methods: The literature search on NPG mentoring in internal medicine was performed on publications across Embase, PsycINFO, ERIC, PubMed, Medline and Scopus databases for articles published between January 2000 to December 2015. The BEME guide and STORIES statement were used to develop a narrative. Results: 1456 citations were reviewed, 8 full text of articles were included and 4 themes were identified through thematic analysis including definitions and descriptions, the structure, the benefits and the obstacles to NPG mentoring. Conclusions: These themes allow for the first evidenced based definition of NPG mentoring. In proffering a means to blending NPG mentoring with novice mentoring, the data suggests the need for effective mentor and mentee training and a flexible structure to the mentoring process that will cater for changes in the evolving relationships but allow effective oversight of the process. Key to this blending process is also maintenance of a social and friendly atmosphere underlining the importance of mentoring environments and highlighting areas for future research.
姑息医学领域训练有素的导师短缺,促使人们努力采用近同伴、同伴和小组(NPG)辅导,以补充传统的新手辅导或高级临床医生与初级医生和/或医学生之间的辅导,以此确保学员能够及时、适当和个性化地获得全面支持。然而,对NPG辅导的主流数据的审查显示,在理解和实践NPG辅导方面存在重大差距,这导致了与指导、角色塑造、赞助、监督和咨询的混淆。未能考虑到辅导的发展、目标敏感、情境特定和关系性、受试者、导师和组织依赖的过程性质,进一步限制了可用的NPG辅导研究。这篇综述旨在促进对NPG指导的临床相关理解,这将有助于描述NPG指导实践,并可能将其与新手指导相结合。方法:在Embase、PsycINFO、ERIC、PubMed、Medline和Scopus数据库的出版物上检索2000年1月至2015年12月期间发表的关于内科NPG指导的文献。BEME指南和STORIES陈述被用来发展叙事。结果:共被引用1456次,收录文章全文8篇,通过主题分析确定了4个主题,包括定义和描述、结构、NPG辅导的好处和障碍。结论:这些主题允许第一个基于证据的NPG指导定义。在提供将NPG辅导与新手辅导相结合的方法时,数据表明,需要有效的导师和学员培训,以及灵活的辅导流程结构,以适应不断发展的关系的变化,但允许对流程进行有效监督。这一融合过程的关键还在于保持社交和友好的氛围,强调指导环境的重要性,并突出未来研究的领域。
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引用次数: 19
Palliative Care - A Noble and Holistic Specialty 姑息治疗——一种高贵而全面的专业
Pub Date : 2017-09-29 DOI: 10.4172/2165-7386.1000322
Marie Joseph
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引用次数: 0
Out-of-Hospital Transfers: When the Intention is not to Cure 院外转移:当目的不是治愈
Pub Date : 2017-09-25 DOI: 10.4172/2165-7386.1000321
C. Gutierrez
Our published single-center cohort study determined the outcomes of out-of-hospital transfer of cancer patients to the Intensive Care Unit (ICU) at MD Anderson Cancer Center [1]. In this three year study 228 patients were transferred for further care to our ICU from outside hospitals all over the country. Surprisingly, and contrary to what was reported in the literature, we observed that transferring critically ill oncological patients to a specialized center did not lead to worse outcomes or increased resource utilization [1].
我们发表的单中心队列研究确定了癌症患者院外转至MD安德森癌症中心重症监护病房(ICU)的结果。在这项为期三年的研究中,有228名患者从全国各地的其他医院转到我们的ICU接受进一步治疗。令人惊讶的是,与文献报道相反,我们观察到将危重肿瘤患者转移到专业中心并没有导致更糟糕的结果或增加资源利用率[10]。
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引用次数: 0
Prolonged Use of Dexmedetomidine Infusion in an Infant for Sedation as Adjuvant Therapy 婴儿长期使用右美托咪定输液作为镇静辅助治疗
Pub Date : 2017-09-16 DOI: 10.4172/2165-7386.1000319
P. Genovese, J. Tobias, A. Kundu
Dexmedetomidine, a central and peripheral alpha-2 receptor agonist approved by the FDA for the use in patients 18 years old and older, it has been increasingly used in the pediatric population for sedation and analgesia due to its advantage of minimal respiratory depression and lack of abuse/dependence. This is a case report of a successful use of dexmedetomidine in an infant for 15 weeks achieving; symptom control, reduction in the dose of opioids and benzodiazepines by 50% and a safe transition to oral equivalents.
右美托咪定是一种经美国食品药品监督管理局批准用于18岁及以上患者的中枢和外周α-2受体激动剂,由于其具有最小呼吸抑制和无滥用/依赖的优势,它在儿科人群中越来越多地用于镇静和镇痛。这是一例在婴儿中成功使用右美托咪定达15周的病例报告;症状控制,将阿片类药物和苯二氮卓类药物的剂量减少50%,并安全过渡到口服等效药物。
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引用次数: 0
FUTURE HOMES: FUSING RESPONSES TO AGEING, SUSTAINABILITY AND DIGITAL INNOVATION IN NEW HOUSING MODELS 未来住宅:在新的住房模式中融合对老龄化、可持续性和数字创新的反应
Pub Date : 2017-09-14 DOI: 10.4172/2165-7386-C1-012
R. Gilroy
Background: There have been numerous anecdotal reports from doctors in East Sussex Healthcare Trust (ESHT) about the difficulties in discussing escalation and resuscitation with patients. We feel the wording of Do Not Attempt Cardiopulmonary Resuscitation (DNACPR) is negative and detrimental to these discussions. The Gold Standard Framework and the GMC recognise an alternative wording: Allow Natural Death. Our project was looking to change the wording of these forms to Allow Natural Death (Do Not Attempt Cardiopulmonary Resuscitation) in an effort to improve this difficult conversation.
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引用次数: 2
A PSYCHOSOCIAL INSTRUMENT TO ASSESS WELL ELDERLY RESIDING IN PRIVATIZED, RESIDENTIAL RETIREMENT COMMUNITIES 一个社会心理工具,以评估老年人居住在私有化,住宅退休社区
Pub Date : 2017-09-13 DOI: 10.4172/2165-7386-C1-010
M. Rosenkoetter
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引用次数: 1
期刊
Journal of palliative care & medicine
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