A. Benbouza, Y. Mebarki, N. Righi, R. Djebaili, O. Mansouri
Context: Tuberculosis is an infectious disease that is endemic in developing countries. The causal agent is Mycobacterium tuberculosis. Extra-pulmonary tuberculosis (EPTB) is receiving renewed attention due to an unexplained increase in its relative frequency. The aim of this study was to carry out a retrospective descriptive survey to assess the frequency of extra-pulmonary tuberculosis in an eastern Algeria population range. Methods: this study took place at the regional tuberculosis Batna’s Public hospitalian establishment unit; over a period of 64 months (2017-2022). 2405 files were studied through the collection of information recorded at laboratory level. Results: Out of 2405 samples, 102 were positive (4.24%). There was a clear predominance of females (64.70%) and males (35.29%), giving a sex ratio of 1.8. The age group most affected was 11 to 49. Pus was the most common specimen with a percentage of 44.12%, followed by urine (28.43%), CSF (14.70%). The incidence of extra pulmonary tuberculosis in patients in Batna’s Department and neighbouring Departments is 4.24%, with adult women being the most affected. Conclusion: Extrapulmonary tuberculosis is common and should not be neglected; it is no longer a pathology of the past but still remains relevant today.
{"title":"Extra-pulmonary tuberculosis frequency and the risk factors influence (case of the PHE-Batna regional unit) (2017-2022)","authors":"A. Benbouza, Y. Mebarki, N. Righi, R. Djebaili, O. Mansouri","doi":"10.14419/tyfk9r02","DOIUrl":"https://doi.org/10.14419/tyfk9r02","url":null,"abstract":"Context: Tuberculosis is an infectious disease that is endemic in developing countries. The causal agent is Mycobacterium tuberculosis. Extra-pulmonary tuberculosis (EPTB) is receiving renewed attention due to an unexplained increase in its relative frequency. The aim of this study was to carry out a retrospective descriptive survey to assess the frequency of extra-pulmonary tuberculosis in an eastern Algeria population range.\u0000Methods: this study took place at the regional tuberculosis Batna’s Public hospitalian establishment unit; over a period of 64 months (2017-2022). 2405 files were studied through the collection of information recorded at laboratory level.\u0000Results: Out of 2405 samples, 102 were positive (4.24%). There was a clear predominance of females (64.70%) and males (35.29%), giving a sex ratio of 1.8. The age group most affected was 11 to 49. Pus was the most common specimen with a percentage of 44.12%, followed by urine (28.43%), CSF (14.70%). The incidence of extra pulmonary tuberculosis in patients in Batna’s Department and neighbouring Departments is 4.24%, with adult women being the most affected.\u0000Conclusion: Extrapulmonary tuberculosis is common and should not be neglected; it is no longer a pathology of the past but still remains relevant today.","PeriodicalId":91290,"journal":{"name":"International journal of medicine","volume":"105 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140659589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Impaired exercise capacity in COPD patients leads to deterioration in their physical activity and quality of life. The aim of our study was to assess the exercise capacity of COPD patients using the 6-minute walk test (6MWT) and to determine the factors limiting their exercise capacity. Methods: Stable COPD patients were included in this study to assess their exercise capacity using the 6-minute walk test (6MWT) and to investigate the relationship between exercise capacity, functional status (FEV1), quadriceps muscle dysfunction (strength and endurance), and fat free mass index (FFMI). Results: 175 COPD patients (166 males and 9 females) aged between 40 and 86 years with a mean age of 67.95 years. The functional stages distribution according to GOLD was GOLDI: 19.43%, GOLDII: 30.29%, GOLDIII: 33.71%, GOLD IV: 16.57%. 25% of patients received long-term oxygen therapy (LTOT). The mean distance covered by COPD patients was 432.26 ± 129.731 meters, corresponding to 64.71 ± 19.04%. 56 (32%) COPD patients had exercise intolerance as assessed by the distance walked over 6 minutes (6MWD). A significant correlation was found between the 6MWD, quadriceps endurance (P<0.000) and FEV1 (p<0.002), whereas no correlation was found with MVC (P<0.039) and (FFMI) (P<0.062). Conclusion: Muscle dysfunction and the severity of bronchial obstruction are the factors most associated with impaired exercise capacity in COPD patients.
{"title":"Factors limiting exercise capacity in COPD patients","authors":"R. Djebaili, N. Righi, A. Benbouza, B. Chiboub","doi":"10.14419/mrga5j48","DOIUrl":"https://doi.org/10.14419/mrga5j48","url":null,"abstract":"Introduction: Impaired exercise capacity in COPD patients leads to deterioration in their physical activity and quality of life. The aim of our study was to assess the exercise capacity of COPD patients using the 6-minute walk test (6MWT) and to determine the factors limiting their exercise capacity.\u0000Methods: Stable COPD patients were included in this study to assess their exercise capacity using the 6-minute walk test (6MWT) and to investigate the relationship between exercise capacity, functional status (FEV1), quadriceps muscle dysfunction (strength and endurance), and fat free mass index (FFMI).\u0000Results: 175 COPD patients (166 males and 9 females) aged between 40 and 86 years with a mean age of 67.95 years. The functional stages distribution according to GOLD was GOLDI: 19.43%, GOLDII: 30.29%, GOLDIII: 33.71%, GOLD IV: 16.57%. 25% of patients received long-term oxygen therapy (LTOT). The mean distance covered by COPD patients was 432.26 ± 129.731 meters, corresponding to 64.71 ± 19.04%. 56 (32%) COPD patients had exercise intolerance as assessed by the distance walked over 6 minutes (6MWD). A significant correlation was found between the 6MWD, quadriceps endurance (P<0.000) and FEV1 (p<0.002), whereas no correlation was found with MVC (P<0.039) and (FFMI) (P<0.062).\u0000Conclusion: Muscle dysfunction and the severity of bronchial obstruction are the factors most associated with impaired exercise capacity in COPD patients.","PeriodicalId":91290,"journal":{"name":"International journal of medicine","volume":"24 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140736595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A 73 year old Indian female with type O blood group came for routine checkup when it was discovered she had elevated levels of serum alkaline phosphatase (600 mg/dL). Other liver function tests were within normal limits. Abdominal imaging revealed grade I fatty liver but an extensive serological search for significant hepatobiliary disease was negative. She is currently under medication for diabetes and hypertension, association with raised enzyme level couldn't be interpreted due to paucity of testing.
一位 73 岁的印度女性，O 型血，来做常规体检时发现血清碱性磷酸酶水平升高（600 毫克/分升）。其他肝功能检查均在正常范围内。腹部影像学检查显示她患有 I 级脂肪肝，但对她进行的重大肝胆疾病血清学检查结果为阴性。她目前正在服用治疗糖尿病和高血压的药物，由于检测项目较少，无法解释酶水平升高的关联。
{"title":"Unravelling the Enigma: A Study on Exploring the Idiopathic Surge in Serum Alkaline Phosphatase Level","authors":"Vishal Kr","doi":"10.14419/3fvczb37","DOIUrl":"https://doi.org/10.14419/3fvczb37","url":null,"abstract":"A 73 year old Indian female with type O blood group came for routine checkup when it was discovered she had elevated levels of serum alkaline phosphatase (600 mg/dL). Other liver function tests were within normal limits. Abdominal imaging revealed grade I fatty liver but an extensive serological search for significant hepatobiliary disease was negative. She is currently under medication for diabetes and hypertension, association with raised enzyme level couldn't be interpreted due to paucity of testing.","PeriodicalId":91290,"journal":{"name":"International journal of medicine","volume":"105 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140236701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Excision repair cross-complementing group 1 (ERCC1) counteracts the cytotoxic effect of cisplatin through its role in DNA repair, and its expression level is a crucial factor for sensitivity to this drug. The objective of this study was to assess the impact of ERCC1 on tumor response and survival in patients with advanced non-small cell lung cancer (NSCLC) treated with a platinum-based regimen. Methods: Analysis of survival and tumor response based on the expression level of ERCC1 (detected by immunohistochemistry) in a cohort of NSCLC patients followed in a standard care setting. Results: Among the 77 cases of NSCLC included, ERCC1 expression was low in 64.9% of cases and high in 35.1% of cases. In the 52 patients treated with cisplatin, survival and tumor response were better in the low-expression group compared to the high-expression group: 14.35 months versus 9.49 months, p=0.022; Objective Response: 42.4% versus 0%, p=0.001. No significant difference was found based on protein expression level in patients treated with carboplatin. Conclusion: ERCC1 overexpression in patients treated with cisplatin predicts a poor tumor response and shorter survival.
{"title":"Lung cancer, predictive factor and ERCC1","authors":"Souad Souilah","doi":"10.14419/378xkf63","DOIUrl":"https://doi.org/10.14419/378xkf63","url":null,"abstract":"Introduction: Excision repair cross-complementing group 1 (ERCC1) counteracts the cytotoxic effect of cisplatin through its role in DNA repair, and its expression level is a crucial factor for sensitivity to this drug. The objective of this study was to assess the impact of ERCC1 on tumor response and survival in patients with advanced non-small cell lung cancer (NSCLC) treated with a platinum-based regimen.\u0000Methods: Analysis of survival and tumor response based on the expression level of ERCC1 (detected by immunohistochemistry) in a cohort of NSCLC patients followed in a standard care setting.\u0000Results: Among the 77 cases of NSCLC included, ERCC1 expression was low in 64.9% of cases and high in 35.1% of cases. In the 52 patients treated with cisplatin, survival and tumor response were better in the low-expression group compared to the high-expression group: 14.35 months versus 9.49 months, p=0.022; Objective Response: 42.4% versus 0%, p=0.001. No significant difference was found based on protein expression level in patients treated with carboplatin.\u0000Conclusion: ERCC1 overexpression in patients treated with cisplatin predicts a poor tumor response and shorter survival.","PeriodicalId":91290,"journal":{"name":"International journal of medicine","volume":"13 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140263096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: In our department, from 2012 to 2020, 33.3% of patients treated for lung cancer were over 70 years old. Our study aimed to estimate overall survival and investigate the significance of prognostic factors in a population of 308 patients aged over 70 with lung cancer, collected from January 2012 to June 2020. Methods: The initial assessment included at least a bronchoscopic examination and thoracic computed tomography. Survival rates were calculated using the Kaplan-Meier method and presented with 95% confidence intervals. The Log-Rank test was utilized for the comparison of survival curves. Results: The 308 cases (9.6% females, 90.4% males) included 92.2% NSCLC (49.6% squamous cell, 45.4% adenocarcinomas) and 7.8% SCLC. The median age at diagnosis was 74 years, 14.6% were non-smokers, and 55.8% were former smokers. 67.9% of patients had at least one comorbidity, 1.6% had a PS equal to 0, and 28.2% had a PS ≥ 2. TNM staging found 9.2% of cases at stages I and II; 31.2% at stage III, and 59.7% at stage IV. The median overall survival was 8.312 months [6.947-9.678], and the 1-year survival rate was 35.1%. Better survival was correlated with female gender, absence of smoking, PS ≤ 1, and TNM staging. Conclusion: All standard therapeutic options for bronchial cancer can be considered in the elderly, but physiological aging and the prevalence of comorbidities alter the risk-benefit ratio of treatments. This emphasizes the need for the implementation of a comprehensive management strategy for this segment of society.
{"title":"Prognosis and survival of lung cancer in the elderly","authors":"Souad Souilah, Nassima Djami","doi":"10.14419/m01nz878","DOIUrl":"https://doi.org/10.14419/m01nz878","url":null,"abstract":"Introduction: In our department, from 2012 to 2020, 33.3% of patients treated for lung cancer were over 70 years old. Our study aimed to estimate overall survival and investigate the significance of prognostic factors in a population of 308 patients aged over 70 with lung cancer, collected from January 2012 to June 2020.\u0000Methods: The initial assessment included at least a bronchoscopic examination and thoracic computed tomography. Survival rates were calculated using the Kaplan-Meier method and presented with 95% confidence intervals. The Log-Rank test was utilized for the comparison of survival curves.\u0000Results: The 308 cases (9.6% females, 90.4% males) included 92.2% NSCLC (49.6% squamous cell, 45.4% adenocarcinomas) and 7.8% SCLC. The median age at diagnosis was 74 years, 14.6% were non-smokers, and 55.8% were former smokers. 67.9% of patients had at least one comorbidity, 1.6% had a PS equal to 0, and 28.2% had a PS ≥ 2. TNM staging found 9.2% of cases at stages I and II; 31.2% at stage III, and 59.7% at stage IV. The median overall survival was 8.312 months [6.947-9.678], and the 1-year survival rate was 35.1%. Better survival was correlated with female gender, absence of smoking, PS ≤ 1, and TNM staging.\u0000Conclusion: All standard therapeutic options for bronchial cancer can be considered in the elderly, but physiological aging and the prevalence of comorbidities alter the risk-benefit ratio of treatments. This emphasizes the need for the implementation of a comprehensive management strategy for this segment of society.","PeriodicalId":91290,"journal":{"name":"International journal of medicine","volume":"5 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140261046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction. Healthcare-associated infections (HAIs) are a serious problem of modern medicine. Patients hospitalized in intensive care units (ICUs) develop HAI significantly more often than patients in other hospital units. Materials and Methods. We carried out a retrospective study spread over 2 years from January 2019 to December 2021. Data were collected on a form established with the microbiology department of the the University Hospital center of Oran, sites of nosocomial infection, germs involved, antibiotic resistance. Results: 886 samples were collected during the study period, of which 660 were positive. 270 patients were admitted to hospital during this period. The average age of our patients was 39.4 years. The most frequently isolated bacteria were Klebsiella pneumoniae ,Acinetobacter baumannii ,Staphylococcus aureus ,and Escherichia coli . Conclusion Infection control based on incidence rate for each type of infection is necessary in ICU to assess the epidemiological situation.
{"title":"Incidence of healthcare-associated infections in intensive care of the emergency department of Oran in Algeria","authors":"Soumia Benbernou, Nabil Ghoumari, Fouzia Kambouche, Rabah Kouadria","doi":"10.14419/623sj981","DOIUrl":"https://doi.org/10.14419/623sj981","url":null,"abstract":"Introduction. Healthcare-associated infections (HAIs) are a serious problem of modern medicine. Patients hospitalized in intensive care units (ICUs) develop HAI significantly more often than patients in other hospital units.\u0000Materials and Methods.\u0000We carried out a retrospective study spread over 2 years from January 2019 to December 2021. Data were collected on a form established with the microbiology department of the the University Hospital center of Oran, sites of nosocomial infection, germs involved, antibiotic resistance.\u0000Results: 886 samples were collected during the study period, of which 660 were positive. 270 patients were admitted to hospital during this period. The average age of our patients was 39.4 years. The most frequently isolated bacteria were Klebsiella pneumoniae ,Acinetobacter baumannii ,Staphylococcus aureus ,and Escherichia coli .\u0000Conclusion Infection control based on incidence rate for each type of infection is necessary in ICU to assess the epidemiological situation.\u0000 ","PeriodicalId":91290,"journal":{"name":"International journal of medicine","volume":"364 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140458649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A variable proportion of patients presenting to the emergency department (ED) with acute asthma require admission to hospital. Previous studies have identified select factors associated with admission following ED presentation .However, patients hospitalized for AEs are highly heterogeneous and remain largely unexplored.This review discusses current aspects on the pathogenesis and pathophysiology of acute severe asthma exacerbations and provides the current perspectives on the management of acute severe asthma attacks in the emergency department and the intensive care unit.
{"title":"Profile of adult patients hospitalized for asthma exacerbation","authors":"Faouzia Kambouche, Rabia Medjane","doi":"10.14419/54x2qn94","DOIUrl":"https://doi.org/10.14419/54x2qn94","url":null,"abstract":"A variable proportion of patients presenting to the emergency department (ED) with acute asthma require admission to hospital. Previous studies have identified select factors associated with admission following ED presentation .However, patients hospitalized for AEs are highly heterogeneous and remain largely unexplored.This review discusses current aspects on the pathogenesis and pathophysiology of acute severe asthma exacerbations and provides the current perspectives on the management of acute severe asthma attacks in the emergency department and the intensive care unit.","PeriodicalId":91290,"journal":{"name":"International journal of medicine","volume":"317 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140458428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Exercise training reactivates the aerobic pathway through physical exercise, thereby improving dyspnea and breaking deconditioning spiral in chronic obstructive pulmonary disease (COPD) patients. Method: 60 COPD patients were selected to benefit from a four-week outpatient exercise training and muscle strengthening program, at a rate of 3 sessions per week, after excluding the following cases: patients who have contraindications to exercise training; severe patients or those receiving long-term oxygen therapy. The program combined exercise training on a bicycle ergometer for 45 min, muscle strengthening of the lower limbs and nutritional monitoring. Nutritional management included a diet based on nutritional status and the prescription of oral food supplements for malnourished COPD patients. Parameters assessed before and after training were bioimpedance analysis (BIA),6MWT, quadriceps isometric voluntary contraction (MVC) and dynamic endurance, and the quality-of-life questionnaire (Q11). Result: Forty COPD patients (36 men and 4 women) aged 67.22 (± 10) years were able to complete the program. Amid them, 36 were non-smokers. Ten patients (GOLD I), 14 patients (GOLD II), 16 patients (GOLD III), no patients (GOLD IV). Dyspnea was stage 2 (± 1) m MRC. After training, quadriceps muscle function ((MVC) and endurance) improved significantly (p < 0.0001). The improvement in distance covered during 6MWT was also significant (p < 0.0001). A significant improvement in quality of life after training was noted on the total score of the Q11 questionnaire. No significant improvement in body composition after training in COPD patients. Conclusion: this study has confirmed the beneficial effects of training mainly on muscle function, effort capacity and quality of life in COPD patients.
{"title":"Exercise training: which impact on COPD patients?","authors":"R. Djebaili, B. Chiboub","doi":"10.14419/xya73q42","DOIUrl":"https://doi.org/10.14419/xya73q42","url":null,"abstract":"Introduction: Exercise training reactivates the aerobic pathway through physical exercise, thereby improving dyspnea and breaking deconditioning spiral in chronic obstructive pulmonary disease (COPD) patients.\u0000Method: 60 COPD patients were selected to benefit from a four-week outpatient exercise training and muscle strengthening program, at a rate of 3 sessions per week, after excluding the following cases: patients who have contraindications to exercise training; severe patients or those receiving long-term oxygen therapy. The program combined exercise training on a bicycle ergometer for 45 min, muscle strengthening of the lower limbs and nutritional monitoring. Nutritional management included a diet based on nutritional status and the prescription of oral food supplements for malnourished COPD patients. Parameters assessed before and after training were bioimpedance analysis (BIA),6MWT, quadriceps isometric voluntary contraction (MVC) and dynamic endurance, and the quality-of-life questionnaire (Q11).\u0000Result: Forty COPD patients (36 men and 4 women) aged 67.22 (± 10) years were able to complete the program. Amid them, 36 were non-smokers. Ten patients (GOLD I), 14 patients (GOLD II), 16 patients (GOLD III), no patients (GOLD IV). Dyspnea was stage 2 (± 1) m MRC. After training, quadriceps muscle function ((MVC) and endurance) improved significantly (p < 0.0001). The improvement in distance covered during 6MWT was also significant (p < 0.0001). A significant improvement in quality of life after training was noted on the total score of the Q11 questionnaire. No significant improvement in body composition after training in COPD patients.\u0000Conclusion: this study has confirmed the beneficial effects of training mainly on muscle function, effort capacity and quality of life in COPD patients.","PeriodicalId":91290,"journal":{"name":"International journal of medicine","volume":"5 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140508612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acute infections are among the risk factors for venous thromboembolism (VTE). The role of chronic infections such as active tuberculosis is poorly defined, although several case reports and case series have suggested a link association between tuberculosis and VTE. The unexpected resurgence of tuberculosis (TB) in developed countries provided the rationale for evaluating VTE as a possible complication of TB; never theless, the topic has received little attention in the literature. Patient and Method: This is a prospective multicenter study done between January 2016 and January 2018. It is about 17 cases of confirmed pulmonary tuberculosis associated with deep vein thrombosis. Results: It is about fifteen men and two women, their average age is 44,88 years. The thromboembolic complication revealed tuberculosis among 2patients, appearing during the hospitalization of 15 patients among which 11of them receiving antituberculosis drug. We have listed 3 cases of immediate pulmonary embolism and 14cases of deep vein thrombosis complicated with pulmonary embolism in 7 cases. These patients received anti-tuberculosis treatment according to the 2RHZE / 4RH protocol and a curative anticoagulant treatment based on low molecular weight heparin. A relay by vitamin K antagonists was instituted after a satisfactory INR control. The average time to effective anticoagulation was 15.12 days with extremes between 08 and 50 days. There was favorable evolution among 14 patients, 1of them was lost to follow-up. Sight and the evolution has been fatal in two case. Conclusion: Thromboembolic (DVT) disease must be sought systematically in the TB patients because of the risk of this complication particularly in extensive and severe forms. Prophylactic anticoagulation therapy finds its indications in these forms.
{"title":"Pulmonary tuberculosis and venous thromboembolism","authors":"Faouzia Kambouche, Labdouni Mohamed El Habib","doi":"10.14419/3aymyf47","DOIUrl":"https://doi.org/10.14419/3aymyf47","url":null,"abstract":"Acute infections are among the risk factors for venous thromboembolism (VTE). The role of chronic infections such as active tuberculosis is poorly defined, although several case reports and case series have suggested a link association between tuberculosis and VTE. The unexpected resurgence of tuberculosis (TB) in developed countries provided the rationale for evaluating VTE as a possible complication of TB; never theless, the topic has received little attention in the literature.\u0000Patient and Method: This is a prospective multicenter study done between January 2016 and January 2018. It is about 17 cases of confirmed pulmonary tuberculosis associated with deep vein thrombosis.\u0000Results: It is about fifteen men and two women, their average age is 44,88 years. The thromboembolic complication revealed tuberculosis among 2patients, appearing during the hospitalization of 15 patients among which 11of them receiving antituberculosis drug. We have listed 3 cases of immediate pulmonary embolism and 14cases of deep vein thrombosis complicated with pulmonary embolism in 7 cases. These patients received anti-tuberculosis treatment according to the 2RHZE / 4RH protocol and a curative anticoagulant treatment based on low molecular weight heparin. A relay by vitamin K antagonists was instituted after a satisfactory INR control. The average time to effective anticoagulation was 15.12 days with extremes between 08 and 50 days.\u0000There was favorable evolution among 14 patients, 1of them was lost to follow-up. Sight and the evolution has been fatal in two case.\u0000Conclusion: Thromboembolic (DVT) disease must be sought systematically in the TB patients because of the risk of this complication particularly in extensive and severe forms. Prophylactic anticoagulation therapy finds its indications in these forms.","PeriodicalId":91290,"journal":{"name":"International journal of medicine","volume":"8 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140513003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-15DOI: 10.14419/ijm.v10i1.32185
Jorge Teodoro Chávez-Pagola, A. Hernández-Zavala, O. Valenzuela-Limón, M. Sánchez-Gutiérrez, J. Izquierdo-Vega
Objective: Non-alcoholic fatty liver disease (NAFLD) represents the most common liver disease worldwide. The Latin American population has the highest obesity rates in the world. The aim was to research the factors associated with NAFLD in young adults. Methods: A cross-sectional study was performed on 171 participants with an average age of 21 years who underwent a physical and laboratory examination, anthropometric evaluation, and abdominal ultrasound. Results: Subjects with NAFLD were significantly overweight, with dyslipidemia, and with atherogenic risk. They had the presence of metabolic syndrome compared to those without NAFLD. Bivariate logistic regression showed that body mass index, atherogenic risk, Homeostatic Model Assessment (HOMA) value, and metabolic syndrome were associated with NAFLD development. Conclusions: The variables of HOMA, metabolic syndrome, and atherogenic risk were most associated as risk predictors of this pathology in young adults.
{"title":"Non-alcoholic fatty liver disease in asymptomatic young adults: association with HOMA, metabolic syndrome, and atherogenic risk","authors":"Jorge Teodoro Chávez-Pagola, A. Hernández-Zavala, O. Valenzuela-Limón, M. Sánchez-Gutiérrez, J. Izquierdo-Vega","doi":"10.14419/ijm.v10i1.32185","DOIUrl":"https://doi.org/10.14419/ijm.v10i1.32185","url":null,"abstract":"Objective: Non-alcoholic fatty liver disease (NAFLD) represents the most common liver disease worldwide. The Latin American population has the highest obesity rates in the world. The aim was to research the factors associated with NAFLD in young adults. Methods: A cross-sectional study was performed on 171 participants with an average age of 21 years who underwent a physical and laboratory examination, anthropometric evaluation, and abdominal ultrasound. Results: Subjects with NAFLD were significantly overweight, with dyslipidemia, and with atherogenic risk. They had the presence of metabolic syndrome compared to those without NAFLD. Bivariate logistic regression showed that body mass index, atherogenic risk, Homeostatic Model Assessment (HOMA) value, and metabolic syndrome were associated with NAFLD development. Conclusions: The variables of HOMA, metabolic syndrome, and atherogenic risk were most associated as risk predictors of this pathology in young adults.","PeriodicalId":91290,"journal":{"name":"International journal of medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48948116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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