Pub Date : 2018-01-01DOI: 10.4172/2376-0281.1000329
A. Wong, L. H. Mak, V. Mok
Conclusion: Our study provides preliminary findings suggesting that both Mozart K.448 and a general relaxing music may reduce the spasticity level. This study suggested that more research is required to strengthen the scientific knowledge of the effects of music intervention on spasticity level in individuals with spasticity. The Effect of Listening to Mozart K.448 Music for Individuals with Spasticity – A Randomized Controlled Trial
{"title":"The Effect of Listening to Mozart K.448 Music for Individuals with Spasticity - A Randomized Controlled Trial","authors":"A. Wong, L. H. Mak, V. Mok","doi":"10.4172/2376-0281.1000329","DOIUrl":"https://doi.org/10.4172/2376-0281.1000329","url":null,"abstract":"Conclusion: Our study provides preliminary findings suggesting that both Mozart K.448 and a general relaxing music may reduce the spasticity level. This study suggested that more research is required to strengthen the scientific knowledge of the effects of music intervention on spasticity level in individuals with spasticity. The Effect of Listening to Mozart K.448 Music for Individuals with Spasticity – A Randomized Controlled Trial","PeriodicalId":91292,"journal":{"name":"International journal of neurorehabilitation","volume":"05 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2376-0281.1000329","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70303236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.4172/2376-0281.1000323
J. A. Franck, R. Smeets, Karolien Renders, H. Seelen
Background: Focal spasticity management in patients in the sub-acute phase after a stroke is mainly based on expert opinion. Evidence for the optimal type and intensity of multidisciplinary rehabilitation programs is scarce. This study will investigate the added-value of reduction of early signs of spasticity in the sub-acute phase after stroke on arm-hand rehabilitation outcome involving a well-described rehabilitation intervention. Reduction of early signs of spasticity will be done using abobotulinum toxin A.
{"title":"Added-value of Early Post-stroke Spasticity Reduction during Arm-hand Rehabilitation in Improving Functional Arm-hand Skill Performance: A Multiple Baseline Single Case Experimental Design Study","authors":"J. A. Franck, R. Smeets, Karolien Renders, H. Seelen","doi":"10.4172/2376-0281.1000323","DOIUrl":"https://doi.org/10.4172/2376-0281.1000323","url":null,"abstract":"Background: Focal spasticity management in patients in the sub-acute phase after a stroke is mainly based on expert opinion. Evidence for the optimal type and intensity of multidisciplinary rehabilitation programs is scarce. This study will investigate the added-value of reduction of early signs of spasticity in the sub-acute phase after stroke on arm-hand rehabilitation outcome involving a well-described rehabilitation intervention. Reduction of early signs of spasticity will be done using abobotulinum toxin A.","PeriodicalId":91292,"journal":{"name":"International journal of neurorehabilitation","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2376-0281.1000323","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70303514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.4172/2376-0281.1000335
D. Zimmerman
While nociception’s role in pain generation is known and understood what is less certain are the processes that drive rapid and profound pain reduction or cessation, particularly when the physical ‘causes’ are reinstated where orthotic use has seen rapid and durable profound pain reduction. There is a balance between nociceptive and antinociceptive systems. This paper looks at unexpectedly rapid and yet durable reduction in pain suffered achieved using non-invasive therapy.
{"title":"Using Motor Reflex Challenge to Identify and Appropriately Treat Nociceptive Sources Offers More Tailored Treatment with Prompt and Durable Outcomes","authors":"D. Zimmerman","doi":"10.4172/2376-0281.1000335","DOIUrl":"https://doi.org/10.4172/2376-0281.1000335","url":null,"abstract":"While nociception’s role in pain generation is known and understood what is less certain are the processes that drive rapid and profound pain reduction or cessation, particularly when the physical ‘causes’ are reinstated where orthotic use has seen rapid and durable profound pain reduction. There is a balance between nociceptive and antinociceptive systems. This paper looks at unexpectedly rapid and yet durable reduction in pain suffered achieved using non-invasive therapy.","PeriodicalId":91292,"journal":{"name":"International journal of neurorehabilitation","volume":"05 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2376-0281.1000335","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70303903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.4172/2376-0281.1000308
F. L. Belozo, C. Katashima, André V Cordeiro, Luciene Lenhare, Jean F. Alves, V. R. Silva
We previously reported evidence about the positive effects of continuous aerobic training (CAT) in hypertensive obese people. We showed that 90 min/week of aerobic exercise on a treadmill (70%-80% of the Maximal Heart Rate [MHR]) was able to improve the systemic blood metabolism of obese subjects. Therefore, we believe that reducing the recommended amount of aerobic exercise (150 min/week) by American College of Sports Medicine (ACSM) is a valuable strategy to for sedentary individuals with pathological conditions, since the suggested protocol is easyto- perform, fast and enjoyable for the subjects. In this comment, we tempt to summarize the literature evidences regarding physical aerobic exercise on cardiac metabolism in hypertensive obese individuals. These findings may influence the consenting information over the prescription of physical activity for individuals with cardiac-associated pathologies.
{"title":"A Commentary on Effects of Ninety Minutes per Week of Continuous Aerobic Exercise on Blood Pressure in Hypertensive Obese Humans","authors":"F. L. Belozo, C. Katashima, André V Cordeiro, Luciene Lenhare, Jean F. Alves, V. R. Silva","doi":"10.4172/2376-0281.1000308","DOIUrl":"https://doi.org/10.4172/2376-0281.1000308","url":null,"abstract":"We previously reported evidence about the positive effects of continuous aerobic training (CAT) in hypertensive obese people. We showed that 90 min/week of aerobic exercise on a treadmill (70%-80% of the Maximal Heart Rate [MHR]) was able to improve the systemic blood metabolism of obese subjects. Therefore, we believe that reducing the recommended amount of aerobic exercise (150 min/week) by American College of Sports Medicine (ACSM) is a valuable strategy to for sedentary individuals with pathological conditions, since the suggested protocol is easyto- perform, fast and enjoyable for the subjects. In this comment, we tempt to summarize the literature evidences regarding physical aerobic exercise on cardiac metabolism in hypertensive obese individuals. These findings may influence the consenting information over the prescription of physical activity for individuals with cardiac-associated pathologies.","PeriodicalId":91292,"journal":{"name":"International journal of neurorehabilitation","volume":"5 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2376-0281.1000308","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70303119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.4172/2376-0281.1000326
Masaru Oga
Higher brain dysfunction after traumatic brain injury in school-aged children potentially have serious impact on their lives than adults, because children are on their developmental way to be mature adults under the environment they should learn various knowledge and skills. Neuropsychological, psychosocial, and academic conditions/outcomes are evaluated by appropriate tools and methods for them. Medical care and support are planned on the basis of their conditions and modified with time in response to their outcomes. Cognitive rehabilitation has been developing to contribute the recovery from their impairment and return to school through four major tactics; improvement of higher brain dysfunction itself, acquirement of compensatory maneuvers/adjustment of environment, support for re-entry to school or finding employment, and acceleration for understanding or acceptance of impairment to people concerned including parents. The number of highly qualified study such as randomized clinical trial or meta-analytic clinical research is still few especially in Japan while developing basic research with a focus on neuroimaging is contributing to the clinical attempt. The issues related to concussion or post-concussion syndrome would be more and more attention in the future.
{"title":"Higher Brain Dysfunction after Traumatic Brain Injury in School-aged Children: Review of the Literature","authors":"Masaru Oga","doi":"10.4172/2376-0281.1000326","DOIUrl":"https://doi.org/10.4172/2376-0281.1000326","url":null,"abstract":"Higher brain dysfunction after traumatic brain injury in school-aged children potentially have serious impact on their lives than adults, because children are on their developmental way to be mature adults under the environment they should learn various knowledge and skills. Neuropsychological, psychosocial, and academic conditions/outcomes are evaluated by appropriate tools and methods for them. Medical care and support are planned on the basis of their conditions and modified with time in response to their outcomes. Cognitive rehabilitation has been developing to contribute the recovery from their impairment and return to school through four major tactics; improvement of higher brain dysfunction itself, acquirement of compensatory maneuvers/adjustment of environment, support for re-entry to school or finding employment, and acceleration for understanding or acceptance of impairment to people concerned including parents. The number of highly qualified study such as randomized clinical trial or meta-analytic clinical research is still few especially in Japan while developing basic research with a focus on neuroimaging is contributing to the clinical attempt. The issues related to concussion or post-concussion syndrome would be more and more attention in the future.","PeriodicalId":91292,"journal":{"name":"International journal of neurorehabilitation","volume":"5 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2376-0281.1000326","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70303153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.4172/2376-0281.1000327
M. Hirose, Y. Furukawa, M. Tsuboi
Volume 5 • Issue 4 • 1000327 Int J Neurorehabilitation, an open access journal ISSN: 2376-0281 *Corresponding author: Masamichi Hirose, MD, PhD, Division of Molecular and Cellular Pharmacology, Department of Pathophysiology and Pharmacology, Iwate Medical University School of Pharmaceutical Science, 2-1-1 Nishitokuta, Yahaba, Iwate 028-3694, Japan, Tel: 81-19-651-5110; Email: mhirose@iwate-med.ac.jp
{"title":"Cardiac Autonomic Disorders and Botulinum Toxin Treatment","authors":"M. Hirose, Y. Furukawa, M. Tsuboi","doi":"10.4172/2376-0281.1000327","DOIUrl":"https://doi.org/10.4172/2376-0281.1000327","url":null,"abstract":"Volume 5 • Issue 4 • 1000327 Int J Neurorehabilitation, an open access journal ISSN: 2376-0281 *Corresponding author: Masamichi Hirose, MD, PhD, Division of Molecular and Cellular Pharmacology, Department of Pathophysiology and Pharmacology, Iwate Medical University School of Pharmaceutical Science, 2-1-1 Nishitokuta, Yahaba, Iwate 028-3694, Japan, Tel: 81-19-651-5110; Email: mhirose@iwate-med.ac.jp","PeriodicalId":91292,"journal":{"name":"International journal of neurorehabilitation","volume":"05 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2376-0281.1000327","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70303164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.4172/2376-0281.1000315
P. Csecsei, L. Nagy, S. Kéki, L. Szapáry, Z. Illés, N. Farkas, T. Molnár
Background: Increased levels of asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA) are associated with endothelial dysfunction. Here, we analyzed the relationship between L-arginine pathway metabolites and functional outcome of ischemic stroke at discharge and 6 months follow-up. Methods: Plasma concentration of L-arginine, ADMA, SDMA were investigated in 46 patients at post-stroke 24 h. Outcome measures were assessed by modified Rankin scale (mRS) at hospital discharge and 6 months follow-up. According to change in mRS score during the 6 months period, patients were divided into subgroups of improved, unchanged and worsened function. Predictive role of L-arginine pathway metabolites were explored in these outcome groups. Results: Significant inverse correlations were found between initial NIHSS and the L-arginine/ADMA, the L-arginine/SDMA ratios and L-arginine plasma concentration (all p<0.05, respectively). Patients with worsened mRS by 6 months had significantly higher L-arginine plasma concentrations at 24 post-stroke hours compared to patients with improved mRS (p<0.001) and unchanged mRS (p<0.005). The L-arginine/ADMA (p<0.004) and the L-arginin/ SDMA (p<0.002) ratios at 24 h were significantly higher among patients with worsened compared to improved mRS. Besides, clinical factors, such as BMI showed negative correlation with L-arginine/ADMA; creatinine showed positive correlation with L-arginine and L-arginine/ADMA; LDL showed positive correlation with L-arginine/SDMA ratio. Plasma concentration of ADMA was significantly higher among smokers compared to non-smokers. The L-arginine/ADMA, the L-arginine/SDMA ratios and L-arginine plasma concentration negatively correlated with change of mRS between hospital discharge and at 6 months. Conclusion: Our data indicate that lower L-arginine/SDMA ratio is associated with worse outcome on the shortterm, but these patients improve on the long-term resulting in association of lower ratios with improving mRS. In contrast, patients with high L-arginine and low mRS improve fast, but will not improve or may even worsen by 6 months indicating a time-dependent biological effect.
{"title":"L-Arginine Pathway Metabolites Predict 6 Months Outcome after Acute Ischemic Stroke","authors":"P. Csecsei, L. Nagy, S. Kéki, L. Szapáry, Z. Illés, N. Farkas, T. Molnár","doi":"10.4172/2376-0281.1000315","DOIUrl":"https://doi.org/10.4172/2376-0281.1000315","url":null,"abstract":"Background: Increased levels of asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA) are associated with endothelial dysfunction. Here, we analyzed the relationship between L-arginine pathway metabolites and functional outcome of ischemic stroke at discharge and 6 months follow-up. Methods: Plasma concentration of L-arginine, ADMA, SDMA were investigated in 46 patients at post-stroke 24 h. Outcome measures were assessed by modified Rankin scale (mRS) at hospital discharge and 6 months follow-up. According to change in mRS score during the 6 months period, patients were divided into subgroups of improved, unchanged and worsened function. Predictive role of L-arginine pathway metabolites were explored in these outcome groups. Results: Significant inverse correlations were found between initial NIHSS and the L-arginine/ADMA, the L-arginine/SDMA ratios and L-arginine plasma concentration (all p<0.05, respectively). Patients with worsened mRS by 6 months had significantly higher L-arginine plasma concentrations at 24 post-stroke hours compared to patients with improved mRS (p<0.001) and unchanged mRS (p<0.005). The L-arginine/ADMA (p<0.004) and the L-arginin/ SDMA (p<0.002) ratios at 24 h were significantly higher among patients with worsened compared to improved mRS. Besides, clinical factors, such as BMI showed negative correlation with L-arginine/ADMA; creatinine showed positive correlation with L-arginine and L-arginine/ADMA; LDL showed positive correlation with L-arginine/SDMA ratio. Plasma concentration of ADMA was significantly higher among smokers compared to non-smokers. The L-arginine/ADMA, the L-arginine/SDMA ratios and L-arginine plasma concentration negatively correlated with change of mRS between hospital discharge and at 6 months. Conclusion: Our data indicate that lower L-arginine/SDMA ratio is associated with worse outcome on the shortterm, but these patients improve on the long-term resulting in association of lower ratios with improving mRS. In contrast, patients with high L-arginine and low mRS improve fast, but will not improve or may even worsen by 6 months indicating a time-dependent biological effect.","PeriodicalId":91292,"journal":{"name":"International journal of neurorehabilitation","volume":"5 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2376-0281.1000315","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70303339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.4172/2376-0281.1000333
M. Rabadi, P. Munden
A 60-year-old edentulous man with past medical history of hyperlipidemia, current smoker, and depression presented to the eye department with a 4-week history of progressive blurred vision. As per patient he saw a “white sheet” in front of his eyes worse in the right eye constantly. After his eye evaluation he was referred to the neurology clinic as he complained of having difficulty finding words to express him-self. He did report of having lost 10 lbs (4.5 kg) in weight during this period but no other complains such as fever, fatigue, sweating, chest pain, shortness of breath or any other neurological complains. There was no history of substance abuse including history of intravenous drug use.
{"title":"Progressive Visual Loss from Roth Spots in a Patient with Infective Endocarditis","authors":"M. Rabadi, P. Munden","doi":"10.4172/2376-0281.1000333","DOIUrl":"https://doi.org/10.4172/2376-0281.1000333","url":null,"abstract":"A 60-year-old edentulous man with past medical history of hyperlipidemia, current smoker, and depression presented to the eye department with a 4-week history of progressive blurred vision. As per patient he saw a “white sheet” in front of his eyes worse in the right eye constantly. After his eye evaluation he was referred to the neurology clinic as he complained of having difficulty finding words to express him-self. He did report of having lost 10 lbs (4.5 kg) in weight during this period but no other complains such as fever, fatigue, sweating, chest pain, shortness of breath or any other neurological complains. There was no history of substance abuse including history of intravenous drug use.","PeriodicalId":91292,"journal":{"name":"International journal of neurorehabilitation","volume":"05 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2376-0281.1000333","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70303823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.4172/2376-0281.1000331
S. Okada
{"title":"Treatment Approaches for Pulmonary Hypertension in Kyphoscoliosis Related Alveolar Hypoventilation","authors":"S. Okada","doi":"10.4172/2376-0281.1000331","DOIUrl":"https://doi.org/10.4172/2376-0281.1000331","url":null,"abstract":"","PeriodicalId":91292,"journal":{"name":"International journal of neurorehabilitation","volume":"05 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2376-0281.1000331","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70303309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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