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Comparison of Three Exercise Modalities on Patient Reported Symptoms of Knee Osteoarthritis: A Randomized Prospective Study 三种运动方式对膝骨关节炎患者报告症状的比较:一项随机前瞻性研究
Pub Date : 2016-10-17 DOI: 10.4172/2167-7921.1000220
M. Silvis, Jillian E. Sylvester, Brittney Hacken, J. Wawrzyniak, R. Kelly, Scott A. Lynch, T. Mosher, V. Chinchilli, K. Black
Objective: The ACSM recommends healthy adults aged 18-65 participate in 30 minutes of moderate-intensity exercise 5 times per week. The benefits of exercise in patients with osteoarthritis (OA) is known, but the best exercise modality to accomplish this is not. This study compared the effect of three exercise modalities on patient reported symptoms of knee OA. Methods: 61 participants with radiographically evident, symptomatic bilateral OA were randomized into exercise modalities: upright cycle, land treadmill, or water treadmill. Participants completed an 8-week exercise program, progressing to achieve 30 minutes moderate exercise per session. WOMAC, KOOS, and SF-12 health surveys were completed at baseline and then weekly throughout the study. Results: All groups improved in regard to WOMAC scores. No statistically significant difference was noted between groups. Using greater than 25% improvement in WOMAC as a threshold for significant change, 80% of the water treadmill group improved vs 60% upright cycle and 62% land treadmill. Study completion rates were highest for the water treadmill group (80%) compared to the land treadmill (62%) and upright cycle (65%), although not statistically significant (p=0.33). Conclusion: An 8 week exercise program improved symptoms in participants with knee OA with no difference based on training device. Moderate aerobic exercise is beneficial for participants with knee OA.
目的:ACSM建议18-65岁的健康成年人每周参加5次30分钟的中等强度运动。运动对骨关节炎(OA)患者的益处是众所周知的,但实现这一目标的最佳运动方式尚不清楚。本研究比较了三种运动方式对患者报告的膝关节OA症状的影响。方法:61名有明显影像学症状的双侧OA患者被随机分为运动方式:直立循环、陆地跑步机或水上跑步机。参与者完成了一项为期8周的锻炼计划,每次进行30分钟的适度锻炼。WOMAC、oos和SF-12健康调查在基线时完成,然后在整个研究期间每周完成一次。结果:两组患者WOMAC评分均有改善。两组间无统计学差异。以WOMAC改善超过25%作为显著变化的阈值,80%的水上跑步机组改善了,而直立跑步机组改善了60%,陆地跑步机组改善了62%。与陆地跑步机组(62%)和直立循环组(65%)相比,水上跑步机组的研究完成率最高(80%),尽管没有统计学意义(p=0.33)。结论:8周的运动计划改善了膝关节OA患者的症状,不同的训练装置没有差异。适度的有氧运动对膝关节OA患者是有益的。
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引用次数: 4
Exploration of Genetic Association Studies with Collagen Variants in Clinically Diagnosed Primary Knee Osteoarthritis in South Indian Population: A Non-replication Study 南印度人群临床诊断的原发性膝骨关节炎中胶原变异的遗传关联研究探索:一项非重复研究
Pub Date : 2016-10-04 DOI: 10.4172/2167-7921.1000218
K. Subramanyam, S. Poornima, I. Khan, Q. Hasan
Osteoarthritis (OA) is the common form of chronic musculoskeletal degenerative joint disease in elder population and earlier studies have correlated the OA with genetics. The aim of this current study was analyse the collagen linked variants such as COL2A1 (rs73297147), CRTL1 (rs73771337), and CRTM (rs74063376) gene polymorphism with clinically diagnosed and radiologically confirmed primary knee osteoarthritis in south Indian population. Two hundred genomic DNA samples were isolated from 100 primary knee OA cases and 100 healthy controls. Genomic DNA was isolated from peripheral blood sample and followed by PCR-RFLP analysis. A significant difference was observed in allele and dominant model in COL2A1 gene polymorphism (G vs A: p=0.01 (OR-1.10-2.48) OR=6.01) and (GG+AG: p=0.001 (OR-1.41-4.74) OR=2.6) within cases and controls. The T allele and TT+GT genotype of CRTL1 gene polymorphism was seen to be a significant difference (G: p=0.005 (OR-1.27-4.64) OR=2.43) and (TT+GT: p=0.01 (OR-1.2-4.74) OR=2.38). The CRTM polymorphism was negatively associated with all alleles and genotypes (p>0.05). GMDR interaction model supports the correlation among these 3 variants. The current results indicate that the rs73297147, rs73771337 polymorphisms in COL2A1 and CRTL1 genes could be associated with developing primary knee OA in south Indian population.
骨关节炎(OA)是老年人慢性肌肉骨骼退行性关节疾病的常见形式,早期的研究已将OA与遗传学联系起来。本研究的目的是分析胶原蛋白相关变异,如COL2A1 (rs73297147)、CRTL1 (rs73771337)和CRTM (rs74063376)基因多态性与临床诊断和放射学证实的南印度人群原发性膝骨关节炎。从100例原发性膝关节OA病例和100例健康对照中分离出200个基因组DNA样本。从外周血中分离基因组DNA,进行PCR-RFLP分析。COL2A1基因多态性的等位基因和显性模式在病例和对照组中存在显著差异(G vs A: p=0.01 (OR-1.10-2.48) OR=6.01), (GG+AG: p=0.001 (OR-1.41-4.74) OR=2.6)。CRTL1基因多态性的T等位基因和TT+GT基因型差异有统计学意义(G: p=0.005 (OR-1.27-4.64) OR=2.43)和(TT+GT: p=0.01 (OR-1.2-4.74) OR=2.38)。CRTM多态性与所有等位基因和基因型呈负相关(p < 0.05)。GMDR相互作用模型支持这三个变量之间的相关性。目前的研究结果表明,COL2A1和CRTL1基因的rs73297147、rs73771337多态性可能与南印度人群原发性膝关节炎的发生有关。
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引用次数: 1
Change in Serum Biomarkers in Patients with Osteoarthritis treated with Collagen Hydrolysate: Results of a Prospective Randomized Study 水解胶原蛋白治疗骨关节炎患者血清生物标志物的变化:一项前瞻性随机研究的结果
Pub Date : 2016-10-03 DOI: 10.4172/2167-7921.1000219
K. Flechsenhar, T. McAlindon
Klaus Flechsenhar1 and Timothy McAlindon2 1Sanofi-Aventis Deutschland GmbH, Frankfurt am Main, Germany 2Tufts Medical Center, Chief, Division of Rheumatology, Boston, USA *Corresponding author: Klaus Flechsenhar, MD, Sanofi-Aventis Deutschland GmbH, Therapeutic Area Immunology, Cytokine Modulation, Industriepark Hoechst, Building H821, Room 525, D-65926 Frankfurt am Main Germany, Tel: +49 69 305 17403; Fax: +49 69 305 47223; E-mail: Klaus.Flechsenhar@sanofi.com
通讯作者:Klaus Flechsenhar,医学博士,赛诺菲-安万特德国有限公司,德国法兰克福2塔夫茨医疗中心,风湿病科主任,美国波士顿*通讯作者:Klaus Flechsenhar,医学博士,赛诺菲-安万特德国有限公司,治疗领域免疫学,细胞因子调节,赫斯特工业园区,H821楼,525室,D-65926德国法兰克福,电话:+49 69 305 17403;传真:+49 69 305 47223;电子邮件:Klaus.Flechsenhar@sanofi.com
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引用次数: 3
Prosthesis-related Indications for Transfemoral Amputation after Total Knee Arthroplasty 全膝关节置换术后经股截肢的相关指征
Pub Date : 2016-09-13 DOI: 10.4172/2167-7921.1000216
P. J. Leute, A. Hammad, F. Braatz, H. Klinger
Objective: Few studies have described the complications leading to transfemoral amputation after total knee arthroplasty. The aim of this study was to demonstrate which long term prosthesis-related complications can lead to the loss of a limb after knee joint replacement and to provide clinical guidance regarding the situations that generate an increased likelihood of a patient requiring above knee amputation after total knee arthroplasty. Methods: All patients who received above knee amputations between 2005 and 2015 at our clinic due to prosthesis-related complications after total knee arthroplasty were included in this retrospective study. We analyzed the frequencies of various reasons for above knee amputation as well as their influence on the decision to amputate. Results: Sixteen patients received a transfemoral amputation after total knee arthroplasty at our clinic during the study period. Joint infection was the principal reason for above knee amputation in all patients, and at least two additional factors that influenced the decision to amputate were present in each presented case. Conclusions: The indication leading to transfemoral amputation after total knee arthroplasty is always multifactorial. An infection is present in most cases as the main contributing factor and is usually accompanied by at least two other factors. In some cases of recurrent persistent periprothetic joint infections, transfemoral amputation remains the only salvage procedure in order to control the infection, and in some cases, it is a life-saving procedure.
目的:对全膝关节置换术后经股截肢并发症的研究较少。本研究的目的是证明长期的假体相关并发症可能导致膝关节置换术后肢体的丧失,并为全膝关节置换术后患者需要截肢的可能性增加的情况提供临床指导。方法:回顾性分析我院2005 - 2015年间因全膝关节置换术后假体相关并发症而行膝以上截肢的患者。我们分析了各种原因导致膝上截肢的频率以及它们对截肢决定的影响。结果:本研究期间16例患者在全膝关节置换术后行经股截肢。关节感染是所有患者进行膝上截肢的主要原因,并且在每个病例中至少存在两个影响截肢决定的其他因素。结论:全膝关节置换术后经股截肢的适应证是多因素的。在大多数情况下,感染是主要因素,通常伴有至少两个其他因素。在一些复发性持续性假体周围关节感染的病例中,经股截肢仍然是控制感染的唯一挽救性手术,在某些情况下,这是一个挽救生命的手术。
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引用次数: 0
Histological Appearance of the Synovial Membrane after Treatment of Knee Osteoarthritis with Polyacrylamide Gel Injections: A Case Report 聚丙烯酰胺凝胶注射治疗膝骨性关节炎后滑膜的组织学表现:1例报告
Pub Date : 2016-09-12 DOI: 10.4172/2167-7921.1000217
L. Christensen, S. Daugaard
Knee osteoarthritis (OA) caused by cartilage damage and synovitis is a painful disease, for which the only effective treatment today is total knee replacement. Polyacrylamide hydrogel (PAAG) is a synthetic non-degradable and non-toxic tissue filler, which allows host cell integration with formation of a scaffold of fibrous tissue inside the gel. A histo-pathological pilot study using this gel for intra-articular injection in rabbit and horse joints has shown that it forms an integrated layer within the upper part of the synovial membrane, and clinical studies of horse joints and human knee joints with OA has shown promising long-term results in pain reduction. It has therefore been the hope that this type of treatment could prolong the time leading up to total knee replacement more effectively than today. The current case report from one of the patients included in the clinical study mentioned above describes, for the first time in a human, how biopsies obtained during meniscectomy after 9 months display the same type of synovial augmentation as seen in horse joints with OA, and that the filler effect from the integrated gel persists in spite of areas with chronic synovitis and microscopic fibrosis.
膝关节骨关节炎(OA)由软骨损伤和滑膜炎引起,是一种痛苦的疾病,目前唯一有效的治疗方法是全膝关节置换术。聚丙烯酰胺水凝胶(PAAG)是一种合成的不可降解和无毒的组织填料,它允许宿主细胞与凝胶内纤维组织的支架形成整合。使用该凝胶在兔和马关节关节内注射的组织病理学初步研究表明,它在滑膜上部形成一个完整的层,对马关节和患有OA的人膝关节的临床研究显示,在减轻疼痛方面有很好的长期效果。因此,人们希望这种治疗方法能够比现在更有效地延长进行全膝关节置换术的时间。上述临床研究中包括的一名患者的病例报告首次在人类中描述了9个月后半月板切除术中获得的活检如何显示与OA马关节相同类型的滑膜增强,并且尽管存在慢性滑膜炎和显微纤维化,但集成凝胶的填充效果仍然存在。
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引用次数: 2
Rheumatology-Ophthalmology Collaborative Uveitis Units may Improve the Diagnostic and Therapeutic Approach of this Pathology: Experience from a Uveitis Unit in a Secondary Spanish Hospital 风湿病-眼科合作葡萄膜炎单位可以改善这种病理的诊断和治疗方法:来自西班牙二级医院葡萄膜炎单位的经验
Pub Date : 2016-08-23 DOI: 10.4172/2167-7921.1000215
Á. Mora, E. Aurrecoechea, A. Corral, J. Calvo
Purpose: The aim of this study is analyze the Etiology of the Uveitis diagnosed in the first three years of a Uveitis unit in a small hospital and share the experience and organization of a collaborative Rheumatology-Ophthalmology Uveitis Unit. Methods: This study includes 136 patients with Uveitis. Results: The most common form of Uveitis was anterior Uveitis (67.2%) and the most common diagnoses were Ankylosing spondylitis (17.8%), Herpes (14.3%), HLA-B27+ (9.5%), Fuchs Heterochromic Iridocyclitis (3.5%). Posterior Uveitis were 16.8% and the most common diagnoses were toxoplasmosis (42.9%), Serpiginous choroidopathy (23.8%), Tuberculosis (4.8%) and Vogt Koyanagi Harada disease (4.8%). Panuveitis was diagnosed in 8.8% of the cases and the most frequent causes were Behcet's disease (18.8%), Endophthalmitis (9%), and Toxoplasmosis (9%). Intermediate Uveitis with 7.2% of the diagnoses, the most frequent were Sarcoidosis (11%), syphilis (11%), and multiple sclerosis (11%). Conclusion: This secondary center based study shows the difference in type of Uveitis and etiology in a secondary hospital from a tertiary one.
目的:本研究旨在分析某小医院葡萄膜炎科室前三年诊断的葡萄膜炎的病因,并分享风湿病-眼科葡萄膜炎联合科室的经验和组织。方法:本研究纳入136例葡萄膜炎患者。结果:葡萄膜炎最常见的形式为前葡萄膜炎(67.2%),最常见的诊断为强直性脊柱炎(17.8%),疱疹(14.3%),HLA-B27+ (9.5%), Fuchs异色虹膜睫状体炎(3.5%)。后葡萄膜炎占16.8%,最常见的诊断为弓形虫病(42.9%)、蛇形脉络膜病(23.8%)、结核病(4.8%)和Vogt Koyanagi Harada病(4.8%)。全葡萄膜炎占8.8%,最常见的病因是白塞病(18.8%)、眼内炎(9%)和弓形虫病(9%)。中度葡萄膜炎占7.2%,最常见的是结节病(11%)、梅毒(11%)和多发性硬化症(11%)。结论:以二级中心为基础的研究显示了二级医院与三级医院在葡萄膜炎类型和病因学上的差异。
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引用次数: 5
Dance-based Exercise Therapy for People with Arthritis: An Update and Commentary 以舞蹈为基础的运动疗法对关节炎患者的治疗:最新进展和评论
Pub Date : 2016-08-15 DOI: 10.4172/2167-7921.1000214
R. Marks
Arthritis, a broad term used to describe more than 100 different health conditions that result in considerable physical disability, is very challenging to treat effectively, regardless of disease type. This brief review revisits the research base concerning the use of dance-based therapeutic exercises as a possible adjunct for ameliorating arthritis. The goal was to provide an overview of the potential of this form of therapy for arthritis patients as well as health professionals working with this population.
关节炎是一个广泛的术语,用于描述100多种不同的健康状况,导致相当大的身体残疾,无论疾病类型如何,有效治疗都非常具有挑战性。这篇简短的综述回顾了关于使用舞蹈为基础的治疗性运动作为改善关节炎的可能辅助的研究基础。目的是为关节炎患者以及与此人群一起工作的卫生专业人员提供这种治疗形式的潜力概述。
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引用次数: 0
Collagen Mutant Mouse Models Provide an Important Tool to Study Osteoarthritis 胶原蛋白突变小鼠模型为研究骨关节炎提供了重要工具
Pub Date : 2016-08-08 DOI: 10.4172/2167-7921.1000213
Brandon J Rose, R. Seegmiller, L. Bridgewater, D. Kooyman
Brandon J Rose1, Robert E Seegmiller2, Laura C Bridgewater3 and David L Kooyman1* 1Department of Physiology and Developmental Biology, Brigham Young University, 4005 LSB, Provo, USA 2College of Dental Medicine, Roseman University of Health Sciences, South Jordan, USA 3Department of Microbiology and Molecular Biology, Brigham Young University, 4007 LSB, Provo, USA *Corresponding author: David L Kooyman, Department of Physiology and Developmental Biology, Brigham Young University, 4005 LSB, Provo, UT 84602, USA, Tel: 801-422-6399; Fax: 801-422-0004; E-mail: david_kooyman@byu.edu
Brandon J Rose1, Robert E Seegmiller2, Laura C Bridgewater3, David L Kooyman1* 1杨百翰大学生理与发育生物学系,4005 LSB, Provo,美国2罗斯曼健康科学大学口腔医学院,南约旦,美国3杨百翰大学微生物与分子生物学系,4007 LSB, Provo,美国*通讯作者:杨百翰大学生理与发育生物学系,4005 LSB, Provo, UT 84602, USA, Tel: 801-422-6399;传真:801-422-0004;电子邮件:david_kooyman@byu.edu
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引用次数: 0
Comparison of the Efficacy of Physiotherapy and Local Corticosteroid Injections on Painful shoulder 物理治疗与局部皮质类固醇注射治疗肩痛的疗效比较
Pub Date : 2016-08-08 DOI: 10.4172/2167-7921.1000212
Aykac Cebicci Mehtap
Objectives: Local corticosteroid injections and physiotherapy are commonly used treatment options for painful shoulder. While evidence for these two interventions is poor we decided to design a study in order to investigate the efficacy of local steroid injections and physiotherapy and compare the results of two treatment groups. Methods: A total of 40 patients admitting with shoulder pain were included in the study. Patients were randomized to two treatment groups. The first group (n=20) received a total of 10 physiotherapy sessions. The second group (n=20) received a single corticosteroid injection for the shoulder joint through posterior approach. In addition, both treatment groups received a standardized exercise program. The patients were evaluated before treatment and 2,4,12,24 weeks after the treatment for the clinical and functional parameteres.  Results: Compared to baseline, statistically significant improvement was noted at all follow-up assessments in both groups in Visual Analog Scala(VAS) score, shoulder ROM(range of motion) measurements, Constant-Murley score(CMS), and Shoulder Disability Questionnaire (SDQ)score. There was no significant difference between the two treatment interventions. Conclusions: Both physiotherapy and local corticosteroid injections are effective in reducing pain and improving functional status in patients for shoulder pain and two methods are not superior to each other.
目的:局部皮质类固醇注射和物理治疗是治疗肩痛的常用方法。虽然这两种干预措施的证据不足,但我们决定设计一项研究,以调查局部类固醇注射和物理治疗的疗效,并比较两组治疗的结果。方法:选取40例肩痛患者作为研究对象。患者被随机分为两个治疗组。第一组(n=20)共接受10次物理治疗。第二组(n=20)经后路单次肩关节皮质类固醇注射。此外,两个治疗组都接受了标准化的锻炼计划。分别于治疗前和治疗后2、4、12、24周对患者的临床和功能指标进行评估。结果:与基线相比,两组的所有随访评估在视觉模拟Scala(VAS)评分、肩部ROM(活动范围)测量、Constant-Murley评分(CMS)和肩部残疾问卷(SDQ)评分方面均有统计学显著改善。两种治疗干预之间无显著差异。结论:物理治疗和局部皮质类固醇注射均能有效减轻肩痛患者的疼痛,改善功能状态,两种方法并不具有优势。
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引用次数: 1
Is there a Difference between Knee Valgus Angles on Landing during Different Hop Tasks 在不同的跳跃任务中,膝关节外翻角度是否有差异
Pub Date : 2016-07-19 DOI: 10.4172/2167-7921.1000210
Waleed K. Alshemimary, L. Herrington
Objective: A brief review of the literature to provide an overview of knee valgus angles during different hop tasks. Methods: A literature search was conducted; electronic databases used included PubMed, and SCOPUS. The inclusion criteria were English language, and publication between January 2010 and May 2015, which assessed the knee valgus angles during hop landings. The studies were evaluated by the researcher through their titles, abstract, as well as how the investigation functioned according to the inclusion/exclusion criteria of the present study. Results: A total of 2 papers were included with full-text, as various studies incorporated designs for knee valgus testing which resulted in alternate findings that could not be analysed or evaluated. Conclusion: No extensive research has been carried out over the past 5 years to evaluate knee valgus angles during hop tests. However, the current study found that the majority of the published studies during 2010 – May 2015 focused on evaluating the performance of landing tasks among participants in different sports (basketball, volleyball). Moreover, it can be concluded from the present review that there still exists failings in the evaluative results from past studies regarding the definitive comparisons between knee valgus angles upon landing, which occur through the measurement of important variables in the utilisation of 2D video analysis (i.e. when using crossover hop tests to measure knee valgus angles).
目的:简要回顾文献,提供不同跳跃任务时膝关节外翻角度的概述。方法:进行文献检索;使用的电子数据库包括PubMed和SCOPUS。纳入标准为英语,并在2010年1月至2015年5月之间发表,评估跳跃着陆时膝关节外翻角度。研究人员通过研究的标题、摘要以及根据本研究的纳入/排除标准调查如何进行评估。结果:共有2篇论文纳入全文,因为各种研究纳入了膝关节外翻测试的设计,导致无法分析或评估的替代结果。结论:在过去的5年中,没有广泛的研究在跳跃试验中评估膝关节外翻角。然而,目前的研究发现,2010年至2015年5月期间发表的大多数研究都集中在评估不同运动(篮球、排球)参与者的着陆任务表现上。此外,从本综述中可以得出结论,在过去的研究中,关于着陆时膝关节外翻角的明确比较的评估结果仍然存在缺陷,这是通过使用二维视频分析(即使用交叉跳跃测试来测量膝关节外翻角)中测量重要变量来实现的。
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引用次数: 0
期刊
Journal of arthritis
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