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Comparison of Microfiber Alteration of Fornix in Idiopathic Normal Pressure Hydrocephalus Patients, Alzheimer’s Disease Patients and Healthy Volunteers via Diffusion Tensor Imaging 弥散张量成像对特发性常压脑积水患者、阿尔茨海默病患者和健康志愿者穹窿微纤维改变的比较
Pub Date : 2019-01-01 DOI: 10.21767/2171-6625.1000283
N. C., Gonthong A, W. J., C. P., C. O, M. W., W. T.
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引用次数: 0
Vertebral Artery Dissection Following Tonic Clonic Seizure 强直性阵挛性发作后椎动脉夹层
Pub Date : 2019-01-01 DOI: 10.36648/2171-6625.10.3.298
R. S, G. V., Hakim M
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引用次数: 0
Spinal Segmental Myoclonus Masquerading as a Psychogenic Movement Disorder 伪装成心因性运动障碍的脊髓节段性肌阵挛
Pub Date : 2019-01-01 DOI: 10.21767/2171-6625.1000282
L. Khanna, A. Batra, Ankita Sharma
Spinal generated movement disorders are uncommon. An elderly gentleman presented with distressing jerks of both lower limbs which caused him much social embarrassment. He had received psychiatric treatment for these abnormal muscular spasms without relief. He had become depressed and withdrawn when he first presented to our outpatient department. A routine clinical examination followed by a long-term video EEG with simultaneous EMG clinched the diagnosis of a spinal segmental myoclonus. He underwent spinal decompression surgery with fixation followed by treatment with levetericetam and clonazepam which relieved his symptoms. Spinal generated movement disorders are uncommon and are often attributed to a psychiatric disorder in the absence of a better explanation. We take this opportunity to elaborate on the case details, investigations and the treatment of spinal myoclonus.
脊柱性运动障碍并不常见。一位上了年纪的绅士表现出两下肢令人痛苦的抽搐,这使他在社交中很尴尬。他曾因这些不正常的肌肉痉挛接受过精神治疗,但没有得到缓解。当他第一次出现在我们的门诊部时,他变得抑郁和孤僻。常规临床检查和长期视频脑电图同时肌电图确定了脊髓节段性肌阵挛的诊断。他接受了脊柱减压手术并固定,随后用左曲西坦和氯硝西泮治疗,症状得到缓解。脊柱产生的运动障碍并不常见,在缺乏更好解释的情况下,通常被归因于精神障碍。我们借此机会详细介绍脊髓肌阵挛的病例细节、调查和治疗。
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引用次数: 0
Clinical Manifestations of Neurosarcoidosis in the Netherlands 荷兰神经结节病的临床表现
Pub Date : 2019-01-01 DOI: 10.36648/2171-6625.10.2.292
M. Voortman, D. Fritz, Oscar J.M. Vogels, Diederik van de Beek, J. Vries, Matthijs C. Brouwer, M. Drent
Background: Neurosarcoidosis is a rare disease. We investigated the prevalence of different manifestations of neurosarcoidosis and the influence of race or gender in the Netherlands, as well as the treatment strategies for neurosarcoidosis patients. Methods: Multicentre observational cohort study of patients with neurosarcoidosis in two tertiary referral centres; the ILD Center of Excellence of the St. Antonius Hospital, Nieuwegein and the Amsterdam University Medical Centre (UMC), the Netherlands, from 2015 till 2017, as well as participants of the Dutch Neurosarcoidosis Registry between June 2014 and December 2017. Results: A total of 194 patients were included, 27 of whom were in the Dutch Neurosarcoidosis Registry, 70 treated at the ILD Center of Excellence and 97 treated at the Amsterdam UMC. Of the 194 patients included, 54% were female. The most common neurosarcoidosis manifestations were chronic meningitis (41%), cranial nerve dysfunction (39%), myelopathy (28%) and cerebral parenchymal disease (26%). Age, gender and race did not differ for the various manifestations, except for peripheral polyneuropathy, which was more prevalent in men than in women (21% versus 10%). Most neurosarcoidosis patients were treated with prednisone (89%), methotrexate (46%) or infliximab (21%). A total of 102 patients (53%) received second- or third-line treatment. Conclusion: In a large cohort of neurosarcoidosis patients, chronic meningitis, cranial nerve dysfunction, spinal cord involvement and cerebral parenchymal disease were the most common manifestations. Age, race and gender did not influence the clinical presentation, except for peripheral polyneuropathy (men>women). Over half of the patients required multiple immunosuppressive treatments.
背景:神经结节病是一种罕见的疾病。我们调查了荷兰不同表现的神经结节病的患病率和种族或性别的影响,以及神经结节病患者的治疗策略。方法:对两家三级转诊中心的神经结节病患者进行多中心观察队列研究;2015年至2017年期间,荷兰新韦格因圣安东尼奥医院和阿姆斯特丹大学医学中心(UMC)的ILD卓越中心,以及2014年6月至2017年12月期间荷兰神经结节病登记处的参与者。结果:共纳入194例患者,其中27例在荷兰神经结节病登记处,70例在ILD卓越中心治疗,97例在阿姆斯特丹UMC治疗。纳入的194例患者中,54%为女性。最常见的神经结节病表现为慢性脑膜炎(41%)、脑神经功能障碍(39%)、脊髓病(28%)和脑实质疾病(26%)。年龄、性别和种族在各种表现上没有差异,除了周围多神经病变,男性比女性更普遍(21%比10%)。大多数神经结节病患者接受强的松(89%)、甲氨蝶呤(46%)或英夫利昔单抗(21%)治疗。102例患者(53%)接受了二线或三线治疗。结论:在大量神经结节病患者中,慢性脑膜炎、脑神经功能障碍、脊髓受累和脑实质疾病是最常见的表现。年龄、种族和性别对临床表现没有影响,除了周围多神经病变(男性比女性多)。超过一半的患者需要多次免疫抑制治疗。
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引用次数: 4
Relationship between Cytochrome P450 G1347A Gene Polymorphism and Risk of Ischemic Stroke in North Indian Population: A Case-Control Study 北印度人群细胞色素P450 G1347A基因多态性与缺血性卒中风险的关系:一项病例对照研究
Pub Date : 2019-01-01 DOI: 10.36648/2171-6625.10.2.297
Ram Sagar, Amit Kumar, S. Misra, Pradeep Kumar, R. Raj, A. Gulati, K. Prasad
Objective: Present study was taken up to establish the association between CYP4F2 G1347A polymorphism and risk of ischemic stroke (IS) in a North Indian population. Methods: In a hospital-based case-control study, 250 cases and 250 age and sex matched control subjects were recruited from Outpatient Department of Neurology, All India Institute of Medical Sciences, New Delhi, India. Polymerase chain reaction – Restriction fragment length polymorphism (PCR-RFLP) was used for genotyping. Data were analyzed using STATA software, Version 13. Results: The mean age of IS patients were 52.83 ± 12.59 years and in control group were 50.97 ± 12.70 years. Genotypic frequency distributions were in accordance with Hardy Weinberg Equilibrium (HWE) in both cases and controls. Conditional logistic regression analysis showed an independent association between CYP450 G1347A gene polymorphism with the risk of IS under dominant model (OR 2.05; 95% CI 1.18 to 3.56). Analysis based on Trial of Org 10172 in Acute Stroke Treatment (TOAST) classification discerned a significant association with Large Vessel Disease (LVD) subtype of IS in both the unadjusted (OR, 2.5; 95% CI 1.49 to 4.20) and adjusted (OR, 3.32; 95% CI 1.72 to 6.43) analysis and a significant association with Small Vessel Disease (SVD) subtype of IS after the adjusted analysis (OR, 2.43; 95% CI 1.14 to 5.16) under recessive model. Conclusion: Present study suggests that CYP4F2 G1347A polymorphism may be an important risk factor for IS mainly for LVD subtype of IS. Prospective studies with large sample size are needed to confirm the present findings.
目的:本研究旨在建立CYP4F2 G1347A多态性与北印度人群缺血性卒中(IS)风险之间的关系。方法:在一项以医院为基础的病例对照研究中,从印度新德里全印度医学科学研究所神经内科门诊招募了250例病例和250例年龄和性别匹配的对照受试者。采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)进行基因分型。数据分析使用STATA软件,版本13。结果:IS患者平均年龄为52.83±12.59岁,对照组平均年龄为50.97±12.70岁。在病例和对照组中,基因型频率分布符合Hardy Weinberg平衡(HWE)。条件logistic回归分析显示,显性模型下CYP450 G1347A基因多态性与IS风险独立相关(OR 2.05;95% CI 1.18 - 3.56)。基于Org 10172在急性卒中治疗(TOAST)分类中的试验分析发现,IS与大血管疾病(LVD)亚型在未调整(OR, 2.5;95% CI 1.49 - 4.20)和校正(OR, 3.32;95% CI 1.72 ~ 6.43),经调整分析后与IS的小血管病(SVD)亚型显著相关(OR, 2.43;95% CI 1.14 ~ 5.16)。结论:CYP4F2 G1347A多态性可能是IS的重要危险因素,主要是LVD亚型。需要大样本量的前瞻性研究来证实目前的发现。
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引用次数: 1
Association between Early Hyperoxia and Neurologic Outcome in Patient with High Grade Aneurysmal Subarachnoid Hemorrhage 高度动脉瘤性蛛网膜下腔出血患者早期高氧与神经系统预后的关系
Pub Date : 2019-01-01 DOI: 10.36648/2171-6625.10.3.299
Camille Beaudeux, L. Kanagaratnam, M. Bard, H. Habchi, B. Marlier, J. Kleiber, V. Legros
Background: Oxygenation support is a common practice in patients with aneurysmal subarachnoid hemorrhage (SAH). The aim of this study was to analyze the association between early hyperoxia and the neurological outcome in patients presenting a High Grade SAH, using the modified Rankin Scale (mRS) at 6 months. Methods: We retrospectively analyzed data of SAH in a single center, retrospective, observational study. The inclusion criteria were patients’ ≥ 18 years-old, under mechanical ventilation upon admission to the intensive care unit (ICU) and presenting an aneurysmal SAH with a WFNS score ≥3. Hyperoxia was defined as PaO2 > 120 mmHg and classified into 3 subgroups: mild (121-200 mmHg), moderate (201-300 mmHg) and severe (> 300 mmHg). Patients with a 6 months-mRS >3 were considered as having a poor outcome. Results: One hundred and thirty-nine patients with aneurysmal SAH were included. 82% of patients were exposed to hyperoxia with predominance of mild hyperoxia (42.8%). A higher yet non-statistical, poor neurologic outcome was identified in the hyperoxic compared to normoxic group (72% vs. 87.7% OR 2.8 [1.02-7.71], p 0.12). Following a multivariate analysis, a statistical trend was identified between the hyperoxic group and a 6-month poor neurological outcome (OR 2.84, 95% CI, 0.99-8.19; p=0.052), but no statistical association was found with delayed cerebral ischemia (OR 1.68, 95% CI, 0.5-5.71, p=0.39) nor with 28-day mortality (OR 2.17, 95% CI, 0.82-5.75, p=0.11). Conclusions: Our findings suggest a statistical trend between early hyperoxia and a poor neurological outcome at 6 months, in patients with a high grade aneurysmal SAH admitted to the ICU. Further, large-scale studies are required to fully evaluate the effects of hyperoxia.
背景:氧合支持是动脉瘤性蛛网膜下腔出血(SAH)患者的常见做法。本研究的目的是在6个月时使用改良的Rankin量表(mRS)分析高级别SAH患者早期高氧与神经系统预后之间的关系。方法:回顾性分析单中心、回顾性、观察性研究中SAH的资料。纳入标准为患者年龄≥18岁,入住重症监护病房(ICU)时采用机械通气,WFNS评分≥3分,表现为动脉瘤性SAH。高氧定义为PaO2 > 120 mmHg,并分为轻度(121-200 mmHg)、中度(201-300 mmHg)和重度(> 300 mmHg) 3个亚组。6个月mrs bbbb3的患者被认为预后较差。结果:纳入139例动脉瘤性SAH患者。82%的患者暴露于高氧,以轻度高氧为主(42.8%)。与常氧组相比,高氧组的神经系统预后更高,但无统计学意义(72% vs. 87.7% OR 2.8 [1.02-7.71], p 0.12)。经过多变量分析,高氧组与6个月神经预后差之间存在统计学趋势(OR 2.84, 95% CI, 0.99-8.19;p=0.052),但与延迟性脑缺血(OR 1.68, 95% CI, 0.5-5.71, p=0.39)和28天死亡率(OR 2.17, 95% CI, 0.82-5.75, p=0.11)均无统计学关联。结论:我们的研究结果表明,在入住ICU的高级别动脉瘤性SAH患者中,早期高氧与6个月时不良神经预后之间存在统计学趋势。此外,需要大规模的研究来充分评估高氧的影响。
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引用次数: 0
The Efficacy of Bisphosphonate to Increase the Skull Density Ratio of MRI-guided Focused Ultrasound Candidates with Brain Disorders 双膦酸盐提高mri引导的脑疾病聚焦超声候选人颅骨密度比的疗效
Pub Date : 2019-01-01 DOI: 10.36648/2171-6625.10.2.293
Hisashi Ito, J. Rumià, Shigeru Fukutake, Kazuaki Yamamoto, Toshio Yamaguchi, T. Taira, T. Kamei
Background: Skull density ratio (SDR) is one of the key factors for the success of MRI-guided focused ultrasound (MRgFUS) treatment for brain diseases. We examined the efficacy of alendronate (Aln) to improve a SDR value. Materials and Methods: The subjects were 6 Parkinson’s disease patients (2 men, 4 women, 70.7 ± 7.7 years old) and 1 essential tremor patient (1 man, 81 years old). Despite of desire to MRgFUS treatment, we could not schedule their treatments because their SDR values were too low. As they coexisted with untreated osteoporosis, we administered 35 mg of Aln weekly and followed their SDR values every 3 months. Results: The SDR value elevated in 4 patients following the administration of Aln and we could perform MRgFUS treatment successfully. No adverse reactions related with Aln were observed. Conclusion: Although it will take several months, Aln may be a useful option for MRgFUS candidates with a low SDR value.
背景:颅骨密度比(SDR)是mri引导下聚焦超声(MRgFUS)治疗脑部疾病成功与否的关键因素之一。我们检测了阿仑膦酸钠(Aln)改善SDR值的功效。材料与方法:研究对象为6例帕金森病患者(男2例,女4例,年龄70.7±7.7岁)和1例特发性震颤患者(男1例,年龄81岁)。尽管他们希望进行MRgFUS治疗,但由于他们的SDR值太低,我们无法安排他们的治疗。由于他们同时患有未经治疗的骨质疏松症,我们每周给予35毫克Aln,并每3个月跟踪他们的SDR值。结果:4例患者给予Aln后SDR值升高,可成功进行MRgFUS治疗。未见与Aln相关的不良反应。结论:虽然需要几个月的时间,但Aln可能是SDR值较低的MRgFUS候选者的有用选择。
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引用次数: 5
Specifying Ontologies in a Social Networking Images’ Sample Obtained with a Multiagent System 在社交网络中指定本体Images’用多代理系统获得的示例
Pub Date : 2019-01-01 DOI: 10.21767/2171-6625.1000285
M. Cisneros, Nemesio Castillo, A. Ochoa, Luis Cisneros, Rosa Saucedo
In the present research, there are described some promising initial results of induced ontologies from vocabularies of labels in Metroflog, which were selected using Multi agent Systems utilizing a model based on suppositions. We describe the utility of the ontology of aspects as a supplement to a system that marks with labelling and we present our model and results. We propose a probabilistic reviewed model, using seed ontologies to induce ontology of aspects, and we describe how the model can integrate inside of the community’s logistics of labelling. An innovation of our research is having been able to improve the characterization of a group of labels associated with different images and how our multi-agent system uses a Belief–Desire-Intention (BDI) architecture is much more suitable to expand our context-based vocabulary and better describe the details fine of each image and what they really represent for a social group.
在本研究中,描述了一些有希望的从Metroflog中标签词汇的诱导本体的初步结果,这些本体是使用基于假设的模型的Multi agent Systems选择的。我们描述了方面本体的效用,作为标记系统的补充,我们展示了我们的模型和结果。我们提出了一个概率审查模型,使用种子本体来诱导方面的本体,并描述了该模型如何集成到社区的标签物流中。我们研究的一个创新是已经能够改进与不同图像相关的一组标签的特征,我们的多智能体系统如何使用信念-欲望-意图(BDI)架构更适合扩展我们基于上下文的词汇,更好地描述每张图像的细节以及它们对社会群体的真正代表。
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引用次数: 0
Physiological Correlates of Arousal: A Metaanalytic Review 唤醒的生理关联:荟萃分析回顾
Pub Date : 2019-01-01 DOI: 10.36648/2171-6625.10.4.302
Dhruv Beri, Jayasankara Reddy K
Background: This paper reviews the physiological correlates of arousal to develop a comprehensive and collective understanding of the physiological correlates of arousal that occurs at different levels, such as emotion, sexual, sleep, mood, cognitive dissonance, and temperament. Objective: Main objective of this review was to have a clear understanding of the various physiological correlates that are associated with arousal. Method: Research articles and books were searched on journals using the keywords ‘physiological correlates of emotional arousal’, ‘physiological correlates of arousal-sleep’, ‘physiological correlates of sexual arousal’. Results and Conclusion: Results from the review indicated that there are numerous correlates of physiological arousal which are based on changes in bodily mechanisms, such as variations in breathing rate, cardiovascular systems, and changes in functioning in certain brain areas.
背景:本文综述了唤醒的生理相关因素,以全面和集体地了解发生在不同层面的唤醒的生理相关因素,如情绪、性、睡眠、情绪、认知失调和气质。目的:本综述的主要目的是清楚地了解与觉醒相关的各种生理相关因素。方法:使用关键词“情绪唤醒的生理关联”、“觉醒-睡眠的生理关联”、“性唤醒的生理关联”在期刊上检索研究论文和书籍。结果和结论:综述的结果表明,生理唤醒有许多相关因素,这些因素基于身体机制的变化,如呼吸频率的变化、心血管系统的变化和某些大脑区域功能的变化。
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引用次数: 8
An old and new challenge for treatment of Alzheimers disease 阿尔茨海默病治疗的新旧挑战
Pub Date : 2018-11-01 DOI: 10.21767/2171-6625-C3-013
M. Tsolaki
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引用次数: 0
期刊
Journal of neurology and neuroscience
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