Pub Date : 2018-11-01DOI: 10.21767/2171-6625-c3-015
V. Rendevski, B. Aleksovski, Mihajlovska Rendevska
{"title":"Prognostic values of peripheral glutamate and TNF levels in patients with intracerebral haemorrhage","authors":"V. Rendevski, B. Aleksovski, Mihajlovska Rendevska","doi":"10.21767/2171-6625-c3-015","DOIUrl":"https://doi.org/10.21767/2171-6625-c3-015","url":null,"abstract":"","PeriodicalId":91329,"journal":{"name":"Journal of neurology and neuroscience","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48662051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-10-22DOI: 10.21767/2171-6625-C3-013)
Joanna Ferrie, Philippa Rewaj
Adults diagnosed with neurological conditions can face a time-limited future with few treatment options. Their experience of receiving a diagnosis is distressing, even when ‘given well’. Distress is exacerbated by waiting times, notions of illegitimacy, progressive and frightening symptoms. This paper draws on a number of studies, using phenomenological qualitative interviews of over 65 families across Scotland (around 15% of families who live with MND in Scotland) between 2011-18. The research draws on the social model of disability, to determine where barriers to being and doing are constructed for participants, and what can be done to remove them. It will reflect particularly on the added value to adults who face dysarthria: voice degradation through impairment (for example through Motor Neurone Disease (Also known as ALS/MND)), of using a voice recording of their own voice, to generate speech. Many rely on augmentative and alternative communication (AAC) to express themselves. However the use of voice output communication aids (VOCAs) while facilitating communication, cannot currently preserve the identity of the individual, as users are restricted to a limited set of impersonal synthetic voices. The Speak Unique project (Led by Dr Rewaj, Euan MacDonald Centre) has explored the value of producing a synthesized voice, built around a person’s own voice, (after recording of a finite number of sentences chosen for their ability to be deconstructed phonetically, for those phonetic building blocks to be reconstructed to produce infinite sentences). This paper draws on an evaluation of this work, amongst other studies into the lived experience of neurological conditions. A diagnosis of a neurological condition is sufficient to trigger a biographical disruption (Bury, 1982) but there are services that enable feelings of control and hope. The impact of recovering ‘their own’ voice was significant for families, impacting positively on well-being, social identity and intimacy. Keywords—ALS/MND, Disability, Impairment, Voice
{"title":"Finding your voice and coping with a distressing diagnosis","authors":"Joanna Ferrie, Philippa Rewaj","doi":"10.21767/2171-6625-C3-013)","DOIUrl":"https://doi.org/10.21767/2171-6625-C3-013)","url":null,"abstract":"Adults diagnosed with neurological conditions can face a time-limited future with few treatment options. Their experience of receiving a diagnosis is distressing, even when ‘given well’. Distress is exacerbated by waiting times, notions of illegitimacy, progressive and frightening symptoms. This paper draws on a number of studies, using phenomenological qualitative interviews of over 65 families across Scotland (around 15% of families who live with MND in Scotland) between 2011-18. The research draws on the social model of disability, to determine where barriers to being and doing are constructed for participants, and what can be done to remove them. \u0000It will reflect particularly on the added value to adults who face dysarthria: voice degradation through impairment (for example through Motor Neurone Disease (Also known as ALS/MND)), of using a voice recording of their own voice, to generate speech. Many rely on augmentative and alternative communication (AAC) to express themselves. However the use of voice output communication aids (VOCAs) while facilitating communication, cannot currently preserve the identity of the individual, as users are restricted to a limited set of impersonal synthetic voices. \u0000The Speak Unique project (Led by Dr Rewaj, Euan MacDonald Centre) has explored the value of producing a synthesized voice, built around a person’s own voice, (after recording of a finite number of sentences chosen for their ability to be deconstructed phonetically, for those phonetic building blocks to be reconstructed to produce infinite sentences). This paper draws on an evaluation of this work, amongst other studies into the lived experience of neurological conditions. \u0000A diagnosis of a neurological condition is sufficient to trigger a biographical disruption (Bury, 1982) but there are services that enable feelings of control and hope. The impact of recovering ‘their own’ voice was significant for families, impacting positively on well-being, social identity and intimacy. \u0000 \u0000Keywords—ALS/MND, Disability, Impairment, Voice","PeriodicalId":91329,"journal":{"name":"Journal of neurology and neuroscience","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43553055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-09-04DOI: 10.21767/2171-6625.1000246
H. Mohammed, M. Khalaf, Mohamed Farrah
Introduction: Cervical disc herniation and degenerative disease of the cervical spine are the most common causes of cervical cord and nerve root dysfunction. The surgical treatment of cervical radiculopathy is still controversial. Instead of two possibilities, nowadays three possible treatments concur with each other: anterior cervical discectomy without implantation of any structure, anterior cervical discectomy with fusion, and finally, cervical discectomy with implantation of disc prosthesis. Patients and methods: Twenty patients with cervical disc herniation with radiculopathy, which had not responded to conservative treatment were treated by anterior decompression and cervical disc replacement. All these patients were evaluated preoperatively clinically and radiologically (plain X-rays of cervical spine; A-P, Lateral and dynamic films: flexion, extension and oblique and MRI cervical spine). Nerve conduction study was done to exclude peripheral compression neuropathy and to confirm radiculopathy in selected cases where double entrapment phenomena suspected and followed up for a period of 1 month to 12 months. The technique followed anterior decompression differed according to the way of reconstruction at each level and the patients were accordingly classified into three groups: group A (1-level fusion); where the anterior decompression was accomplished by single level cervical discectomy, and then insertion of cervical cage at this leve, group B (2-level fusion); where the anterior decompression was accomplished by double level cervical discectomy, and then insertion of cervical cage at both levels, group C (hybrid construct); where the anterior decompression was in the form of one level cervical discectomy, followed by cage implantation at this level and another level cervical discectomy followed by insertion of cervical disc prosthesis at the same time. Functional outcome was assessed according to Odom’s criteria. Postoperative plain X-rays of cervical spine (A-P and Lateral) were done at follow-up visits (immediate postoperative, 3 months, 6 months 12 month postoperatively. MRI or CT of the cervical spine is done for patients routinely and for patients not improving or with persistent preoperative complaint or any new neurologic deficit. Results and Discussion: The ages in our patient population ranged from 30 to 50 years, with a mean of 40 ± 5.9 years (mean ± standard deviation). 11/20 patients (55%) were males, and 9/20 (45%) were females. The commonest level affected is C5-C6 level. The most common complaint of patients is neck pain and radiculopathy. Anterior cervical discectomy followed by single level cervical fusion was done on 13 patients, while 5 patients were subjected to anterior cervical discectomy followed by double level cervical fusion and another 2 patients had anterior cervical discectomy followed by cervical artificial disc replacement at one level and zero profile implant insertion and fusion at another level. Regard
{"title":"Evaluation of Different Modalities of Anterior Cervical Discectomy for Treatment of Single and Double Level Cervical Disc Herniation","authors":"H. Mohammed, M. Khalaf, Mohamed Farrah","doi":"10.21767/2171-6625.1000246","DOIUrl":"https://doi.org/10.21767/2171-6625.1000246","url":null,"abstract":"Introduction: Cervical disc herniation and degenerative disease of the cervical spine are the most common causes of cervical cord and nerve root dysfunction. The surgical treatment of cervical radiculopathy is still controversial. Instead of two possibilities, nowadays three possible treatments concur with each other: anterior cervical discectomy without implantation of any structure, anterior cervical discectomy with fusion, and finally, cervical discectomy with implantation of disc prosthesis. \u0000Patients and methods: Twenty patients with cervical disc herniation with radiculopathy, which had not responded to conservative treatment were treated by anterior decompression and cervical disc replacement. All these patients were evaluated preoperatively clinically and radiologically (plain X-rays of cervical spine; A-P, Lateral and dynamic films: flexion, extension and oblique and MRI cervical spine). Nerve conduction study was done to exclude peripheral compression neuropathy and to confirm radiculopathy in selected cases where double entrapment phenomena suspected and followed up for a period of 1 month to 12 months. \u0000The technique followed anterior decompression differed according to the way of reconstruction at each level and the patients were accordingly classified into three groups: group A (1-level fusion); where the anterior decompression was accomplished by single level cervical discectomy, and then insertion of cervical cage at this leve, group B (2-level fusion); where the anterior decompression was accomplished by double level cervical discectomy, and then insertion of cervical cage at both levels, group C (hybrid construct); where the anterior decompression was in the form of one level cervical discectomy, followed by cage implantation at this level and another level cervical discectomy followed by insertion of cervical disc prosthesis at the same time. Functional outcome was assessed according to Odom’s criteria. Postoperative plain X-rays of cervical spine (A-P and Lateral) were done at follow-up visits (immediate postoperative, 3 months, 6 months 12 month postoperatively. MRI or CT of the cervical spine is done for patients routinely and for patients not improving or with persistent preoperative complaint or any new neurologic deficit. \u0000Results and Discussion: The ages in our patient population ranged from 30 to 50 years, with a mean of 40 ± 5.9 years (mean ± standard deviation). 11/20 patients (55%) were males, and 9/20 (45%) were females. The commonest level affected is C5-C6 level. The most common complaint of patients is neck pain and radiculopathy. Anterior cervical discectomy followed by single level cervical fusion was done on 13 patients, while 5 patients were subjected to anterior cervical discectomy followed by double level cervical fusion and another 2 patients had anterior cervical discectomy followed by cervical artificial disc replacement at one level and zero profile implant insertion and fusion at another level. \u0000Regard","PeriodicalId":91329,"journal":{"name":"Journal of neurology and neuroscience","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21767/2171-6625.1000246","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47211367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-08-29DOI: 10.21767/2171-6625-C2-011
Linda Sage
{"title":"Overcome compassion fatigue and burnout","authors":"Linda Sage","doi":"10.21767/2171-6625-C2-011","DOIUrl":"https://doi.org/10.21767/2171-6625-C2-011","url":null,"abstract":"","PeriodicalId":91329,"journal":{"name":"Journal of neurology and neuroscience","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45301132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01Epub Date: 2018-03-28DOI: 10.21767/2171-6625.1000251
R B Bassey, S N Chapman, M Pessu, A Jayam-Trouth, M C Gondré-Lewis
Background: Human immunodeficiency virus (HIV) infection remains a serious immunological disease with new infections in the U.S. disproportionately reported in minority populations. For many years, the District of Columbia (DC) has reported the highest HIV infection rate in the nation. Drug abuse and addiction is also prevalent in DC and has traditionally been linked to HIV/AIDS because of the likelihood for opportunistic infections. Despite this data, the relationship between HIV status, drugs of abuse, and the incidence of neurological disorders are scarcely reported for minority populations.
Method: We carried out a retrospective study on the prevalence of substance abuse in HIV and their association with neuropsychiatric comorbidities in an African American subpopulation in Washington DC.
Findings: Our data suggests an 86 percent prevalence of drug use in the HIV patients with neuropsychiatric comorbidities, with cocaine use being significantly higher in patients with major depressive disorder (MDD) and bipolar disorder (BD), whereas PCP use was associated with patients with schizophrenia. The mean CD4 count was elevated in patients with neuropsychiatric disease, and specifically in MDD patients. CD8 counts were elevated as expected for HIV status but were not influenced by disease diagnosis. A majority (2/3) of patients were on HAART therapy, however the records did not account for adherence.
Conclusion: These data suggest that neuropsychiatric comorbidities are independent of HIV disease progression but are correlated with certain illicit drugs of abuse.
{"title":"Is the History of Substance Abuse Correlated with Neuropsychiatric Disorders and Co-morbid HIV Infection? An Urban Population Study.","authors":"R B Bassey, S N Chapman, M Pessu, A Jayam-Trouth, M C Gondré-Lewis","doi":"10.21767/2171-6625.1000251","DOIUrl":"https://doi.org/10.21767/2171-6625.1000251","url":null,"abstract":"<p><strong>Background: </strong>Human immunodeficiency virus (HIV) infection remains a serious immunological disease with new infections in the U.S. disproportionately reported in minority populations. For many years, the District of Columbia (DC) has reported the highest HIV infection rate in the nation. Drug abuse and addiction is also prevalent in DC and has traditionally been linked to HIV/AIDS because of the likelihood for opportunistic infections. Despite this data, the relationship between HIV status, drugs of abuse, and the incidence of neurological disorders are scarcely reported for minority populations.</p><p><strong>Method: </strong>We carried out a retrospective study on the prevalence of substance abuse in HIV and their association with neuropsychiatric comorbidities in an African American subpopulation in Washington DC.</p><p><strong>Findings: </strong>Our data suggests an 86 percent prevalence of drug use in the HIV patients with neuropsychiatric comorbidities, with cocaine use being significantly higher in patients with major depressive disorder (MDD) and bipolar disorder (BD), whereas PCP use was associated with patients with schizophrenia. The mean CD4 count was elevated in patients with neuropsychiatric disease, and specifically in MDD patients. CD8 counts were elevated as expected for HIV status but were not influenced by disease diagnosis. A majority (2/3) of patients were on HAART therapy, however the records did not account for adherence.</p><p><strong>Conclusion: </strong>These data suggest that neuropsychiatric comorbidities are independent of HIV disease progression but are correlated with certain illicit drugs of abuse.</p>","PeriodicalId":91329,"journal":{"name":"Journal of neurology and neuroscience","volume":"9 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21767/2171-6625.1000251","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36373872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.21767/2171-6625.1000263
A. Seiyama, Keijiro Yamada, Kaori Osaki, R. Nakai, Junya Matsumoto, A. Yoshimura
Background: When developing social infrastructures, people look towards urban planning to promote a comfortable and healthy daily life. Urbanization is hypothesised to lead to various mental disorders. Further, urban upbringing and city living are reported to have dissociable effects on social evaluative stress processing. This necessitates the evaluation of the medical impact of the appearance of cityscapes. However, the neural processes for cityscape perception are still unknown. Methods and Findings: Using functional magnetic resonance imaging (fMRI), we show that two kinds of landscape pictures, Japanese traditional architecture/ nature images (JTANs) and modern cityscapes (MCs), have distinct effects on human brain activation. While participants viewed pictures of the above-mentioned landscapes, their brain activity was more prominent in the dorsal than the ventral visual pathway, and activation in the right precuneus was evident during the viewing of the JTAN pictures. Moreover, the cerebellum and hippocampus were activated during the viewing of unpleasant MC pictures. Conclusion: Our results suggest that the dorsal pathway and the right precuneus play important roles in scenery evaluation, while the ventral pathway and the left lingual gyrus are involved in unpleasant emotion generation.
{"title":"Neural Bases on Cognitive Aspect of Landscape Evaluation: A Study Using Functional Magnetic Resonance Imaging","authors":"A. Seiyama, Keijiro Yamada, Kaori Osaki, R. Nakai, Junya Matsumoto, A. Yoshimura","doi":"10.21767/2171-6625.1000263","DOIUrl":"https://doi.org/10.21767/2171-6625.1000263","url":null,"abstract":"Background: When developing social infrastructures, people look towards urban planning to promote a comfortable and healthy daily life. Urbanization is hypothesised to lead to various mental disorders. Further, urban upbringing and city living are reported to have dissociable effects on social evaluative stress processing. This necessitates the evaluation of the medical impact of the appearance of cityscapes. However, the neural processes for cityscape perception are still unknown. Methods and Findings: Using functional magnetic resonance imaging (fMRI), we show that two kinds of landscape pictures, Japanese traditional architecture/ nature images (JTANs) and modern cityscapes (MCs), have distinct effects on human brain activation. While participants viewed pictures of the above-mentioned landscapes, their brain activity was more prominent in the dorsal than the ventral visual pathway, and activation in the right precuneus was evident during the viewing of the JTAN pictures. Moreover, the cerebellum and hippocampus were activated during the viewing of unpleasant MC pictures. Conclusion: Our results suggest that the dorsal pathway and the right precuneus play important roles in scenery evaluation, while the ventral pathway and the left lingual gyrus are involved in unpleasant emotion generation.","PeriodicalId":91329,"journal":{"name":"Journal of neurology and neuroscience","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21767/2171-6625.1000263","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68069651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.21767/2171-6625.1000244
A. Szűcs, A. Horváth, D. Fabó, A. Kovács, G. Szabó, P. Halász
Epilepsies, especially mesiotemporal epilepsy in adulthood, are frequently associated with chronic cognitive loss, psychiatry symptoms and conditions. We aim to present the pathophysiology of interictal psychiatric comorbidities interlocked with cognitive loss; severely compromising the quality of life of epilepsy patients. We will present the mechanism of cognitive harm related to interictal spiking; and the abnormalities of brain networks in epilepsy, especially of the default mode network, briefly looking into psychosocial and pharmacology effects, too. In addition to seizures, interictal epileptic activity, mainly in sleep, may exert chronic cognitive harm, increasing the risk for primarily non-cognitive psychotic conditions as well. Interictal spikes and pathological high frequency oscillations curiously resemble normal memory traces; enabling them to “behave” and be mistaken for engrams by the memory process. Epileptic activity impairs the white and grey matter of the brain; likely contributing to brain network changes. The epileptic network changes resemble those seen in non-epileptic psychiatry conditions, offering a network-interpretation of psychiatric comorbidity.
{"title":"A Review on the Pathomechanism of Interictal Psychiatry Comorbidities in Epilepsy","authors":"A. Szűcs, A. Horváth, D. Fabó, A. Kovács, G. Szabó, P. Halász","doi":"10.21767/2171-6625.1000244","DOIUrl":"https://doi.org/10.21767/2171-6625.1000244","url":null,"abstract":"Epilepsies, especially mesiotemporal epilepsy in adulthood, are frequently associated with chronic cognitive loss, psychiatry symptoms and conditions. We aim to present the pathophysiology of interictal psychiatric comorbidities interlocked with cognitive loss; severely compromising the quality of life of epilepsy patients. We will present the mechanism of cognitive harm related to interictal spiking; and the abnormalities of brain networks in epilepsy, especially of the default mode network, briefly looking into psychosocial and pharmacology effects, too. In addition to seizures, interictal epileptic activity, mainly in sleep, may exert chronic cognitive harm, increasing the risk for primarily non-cognitive psychotic conditions as well. Interictal spikes and pathological high frequency oscillations curiously resemble normal memory traces; enabling them to “behave” and be mistaken for engrams by the memory process. Epileptic activity impairs the white and grey matter of the brain; likely contributing to brain network changes. The epileptic network changes resemble those seen in non-epileptic psychiatry conditions, offering a network-interpretation of psychiatric comorbidity.","PeriodicalId":91329,"journal":{"name":"Journal of neurology and neuroscience","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21767/2171-6625.1000244","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68066987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.21767/2171-6625.1000256
Hisashi Ito, R. Onders, Shigeru Fukutake, Sanae Odake, Shunsaku Kohriki, J. Kawachi, T. Kamei
Background: To investigate the efficacy of electrical diaphragm pacing (DP) for sleep condition in patients with amyotrophic lateral sclerosis (ALS). Method: We investigated 5 Japanese ALS patients without positive-pressure mechanical ventilation (3 men and 2 women, aged 59.6 ± 9.6 years). All of them were implanted NeuRx RA/4 Diaphragm Pacing System R (NeuRx) in the diaphragm laparoscopically. We assessed physical status and polysomnographic recordings before implantation and after 6 months of conditioning with DP turned on. Results: 4 patients completed the evaluation. Sleep condition showed the tendency to improve far from getting worse despite of deterioration of physical status and respiratory function. Conclusion: DP with NeuRx might assist the sleep condition in ALS patients at least in 6 months of follow up.
{"title":"Diaphragm Pacing Could Have Efficacy for Sleep Condition in Patients with Amyotrophic Lateral Sclerosis","authors":"Hisashi Ito, R. Onders, Shigeru Fukutake, Sanae Odake, Shunsaku Kohriki, J. Kawachi, T. Kamei","doi":"10.21767/2171-6625.1000256","DOIUrl":"https://doi.org/10.21767/2171-6625.1000256","url":null,"abstract":"Background: To investigate the efficacy of electrical diaphragm pacing (DP) for sleep condition in patients with amyotrophic lateral sclerosis (ALS). Method: We investigated 5 Japanese ALS patients without positive-pressure mechanical ventilation (3 men and 2 women, aged 59.6 ± 9.6 years). All of them were implanted NeuRx RA/4 Diaphragm Pacing System R (NeuRx) in the diaphragm laparoscopically. We assessed physical status and polysomnographic recordings before implantation and after 6 months of conditioning with DP turned on. Results: 4 patients completed the evaluation. Sleep condition showed the tendency to improve far from getting worse despite of deterioration of physical status and respiratory function. Conclusion: DP with NeuRx might assist the sleep condition in ALS patients at least in 6 months of follow up.","PeriodicalId":91329,"journal":{"name":"Journal of neurology and neuroscience","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21767/2171-6625.1000256","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68068020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.21767/2171-6625.1000257
Hisashi Ito, Shigeru Fukutake, T. Kamei
We herein report a case of left hemifacial spasm (HFS) developed ipsilateral facial nerve palsy 5 days after botulinum toxin type A (BTX-A) injection. Multiple facial muscles presented weakness regardless of BTX-A injection and electrophysiological study revealed left facial nerve palsy. Facial nerve palsy improved completely after 24 weeks. Facial nerve palsy is a common disease and could occur as a coincidence. On the other hand, BTX-A might cause neuropathy in some previously reported cases and our case. Although the pathogenesis of neuropathy following BTX-A injection has not been elucidated, this is the first case of ipsilateral facial nerve palsy following BTXA injection for HFS. Thorough neurological examination and electrophysiological study were useful for distinguishing facial nerve palsy from facial muscles weakness related with botulinum toxin.
{"title":"Facial Nerve Palsy after Botulinum Toxin Therapy for Hemifacial Spasm: A Case Report","authors":"Hisashi Ito, Shigeru Fukutake, T. Kamei","doi":"10.21767/2171-6625.1000257","DOIUrl":"https://doi.org/10.21767/2171-6625.1000257","url":null,"abstract":"We herein report a case of left hemifacial spasm (HFS) developed ipsilateral facial nerve palsy 5 days after botulinum toxin type A (BTX-A) injection. Multiple facial muscles presented weakness regardless of BTX-A injection and electrophysiological study revealed left facial nerve palsy. Facial nerve palsy improved completely after 24 weeks. Facial nerve palsy is a common disease and could occur as a coincidence. On the other hand, BTX-A might cause neuropathy in some previously reported cases and our case. Although the pathogenesis of neuropathy following BTX-A injection has not been elucidated, this is the first case of ipsilateral facial nerve palsy following BTXA injection for HFS. Thorough neurological examination and electrophysiological study were useful for distinguishing facial nerve palsy from facial muscles weakness related with botulinum toxin.","PeriodicalId":91329,"journal":{"name":"Journal of neurology and neuroscience","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21767/2171-6625.1000257","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68068119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.21767/2171-6625.1000261
Hisashi Ito, Shigeru Fukutake, Sanae Odake, J. Kawada, S. Iwanaga, T. Kamei
Background: Parkinson’s disease (PD) is a common movement disorder with a wide range of non-motor symptoms. Depression is one of these symptoms; however, its pathomechanism and management remains to be elucidated. We evaluated of istradefylline (ISD), a first selective adenosine A2A receptor antagonist, for the treatment of depression in PD. Method: This was an open-labeled, prospective study that enrolled 15 PD patients (Men 8, Women 7) with motor fluctuations who fully filled UK PD society brain bank clinical diagnostic criteria. We added ISD 20 mg/day for 4 weeks followed with 40 mg/day for next 4 weeks on the preceding anti-parkinsonian medications. We evaluated Patient Health Questionnaire (PHQ-9) and Unified PD Rating Scale (UPDRS) part III (on state) at baseline and 8 weeks follow-up. Results: 14 patients completed the evaluations. PHQ-9 scores improved in 5 patients (responder). PHQ-9 scores of responders at baseline were higher than those of nonresponders; however, there was no significant difference. Furthermore, there were no significant differences in UPDRS part III, age, onset, duration, daily levodopa dose, and levodopa equivalent dose at baseline among both groups. UPDRS part III scores improved in both groups; however, there was also no significant difference between them. Conclusion: ISD could have efficacy to depression in some PD patients.
{"title":"Clinical Efficacy of Istradefylline for Depression in Parkinson’s Disease","authors":"Hisashi Ito, Shigeru Fukutake, Sanae Odake, J. Kawada, S. Iwanaga, T. Kamei","doi":"10.21767/2171-6625.1000261","DOIUrl":"https://doi.org/10.21767/2171-6625.1000261","url":null,"abstract":"Background: Parkinson’s disease (PD) is a common movement disorder with a wide range of non-motor symptoms. Depression is one of these symptoms; however, its pathomechanism and management remains to be elucidated. We evaluated of istradefylline (ISD), a first selective adenosine A2A receptor antagonist, for the treatment of depression in PD. Method: This was an open-labeled, prospective study that enrolled 15 PD patients (Men 8, Women 7) with motor fluctuations who fully filled UK PD society brain bank clinical diagnostic criteria. We added ISD 20 mg/day for 4 weeks followed with 40 mg/day for next 4 weeks on the preceding anti-parkinsonian medications. We evaluated Patient Health Questionnaire (PHQ-9) and Unified PD Rating Scale (UPDRS) part III (on state) at baseline and 8 weeks follow-up. Results: 14 patients completed the evaluations. PHQ-9 scores improved in 5 patients (responder). PHQ-9 scores of responders at baseline were higher than those of nonresponders; however, there was no significant difference. Furthermore, there were no significant differences in UPDRS part III, age, onset, duration, daily levodopa dose, and levodopa equivalent dose at baseline among both groups. UPDRS part III scores improved in both groups; however, there was also no significant difference between them. Conclusion: ISD could have efficacy to depression in some PD patients.","PeriodicalId":91329,"journal":{"name":"Journal of neurology and neuroscience","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21767/2171-6625.1000261","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68068400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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