Pub Date : 2021-01-01DOI: 10.36648/2171-6625.21.12.378
Pratham D Shetty
Gerstmann-Straussler-Scheinker Disease (GSS) is an extremely rare, usually familial, fatal prion disease. Such disease affects our one of the most important part of our body that is responsible for our thoughts and coordination of our sensory information, the Nervous System. Some particular variations in the PNRP gene leading to the atypical shape of the prion protein give rise to this disease. PRNP encodes a protein called prion protein (Prp). We are unaware of its functions but we do know that Prp plays a very significant role in the functioning of the human brain and other parts of the human nervous system. The destruction of neural cells due to the clumping of abnormal proteins is one of the characteristic features of this disease. The continuous deterioration of the section of our brain responsible for the motor control in a human body, the cerebellum, and different degrees of dementia are the main characteristics of GSS. Weakness in the legs, diminished reflexes, cognitive decline, ataxia including slurred speech and reduced coordination, and spasticity are some of the main symptoms seen in a person suffering from GSS. The median survival time from onset to death of GSS patients ranges from two to ten years after its diagnosis. The objective of this paper to gather all the data and information available about this rare disease so that future researchers who are interested in this field can refer to this paper without having to curate it all by themselves saving time and increasing their efficiency towards solving this mystery. We are very behind in the understanding of the pathophysiological processes that underlie this disease. Through this paper, we have analyzed and reviewed all the literature on this topic to summarize what is our current understanding of this disease and the possible treatments to cure it or alleviate its symptoms. Through a thorough literature review, we can conclude that research on this topic has potential. With mostly case reports on this disease, the research for its cure and treatments for alleviating its symptoms are not yet advanced.
{"title":"Gerstmann-Straussler-Scheinker Disease - A Review","authors":"Pratham D Shetty","doi":"10.36648/2171-6625.21.12.378","DOIUrl":"https://doi.org/10.36648/2171-6625.21.12.378","url":null,"abstract":"Gerstmann-Straussler-Scheinker Disease (GSS) is an extremely rare, usually familial, fatal prion disease. Such disease affects our one of the most important part of our body that is responsible for our thoughts and coordination of our sensory information, the Nervous System. Some particular variations in the PNRP gene leading to the atypical shape of the prion protein give rise to this disease. PRNP encodes a protein called prion protein (Prp). We are unaware of its functions but we do know that Prp plays a very significant role in the functioning of the human brain and other parts of the human nervous system. The destruction of neural cells due to the clumping of abnormal proteins is one of the characteristic features of this disease. The continuous deterioration of the section of our brain responsible for the motor control in a human body, the cerebellum, and different degrees of dementia are the main characteristics of GSS. Weakness in the legs, diminished reflexes, cognitive decline, ataxia including slurred speech and reduced coordination, and spasticity are some of the main symptoms seen in a person suffering from GSS. The median survival time from onset to death of GSS patients ranges from two to ten years after its diagnosis. The objective of this paper to gather all the data and information available about this rare disease so that future researchers who are interested in this field can refer to this paper without having to curate it all by themselves saving time and increasing their efficiency towards solving this mystery. We are very behind in the understanding of the pathophysiological processes that underlie this disease. Through this paper, we have analyzed and reviewed all the literature on this topic to summarize what is our current understanding of this disease and the possible treatments to cure it or alleviate its symptoms. Through a thorough literature review, we can conclude that research on this topic has potential. With mostly case reports on this disease, the research for its cure and treatments for alleviating its symptoms are not yet advanced.","PeriodicalId":91329,"journal":{"name":"Journal of neurology and neuroscience","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69700091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.36648/2171-6625.12.1.350
Fetlework Tenssay
The present study was designed to determine whether or not there are components of the ERPs that discriminate the erotic and negative pictures during affective picture processing. Participants viewed erotic, negative and neutral pictures form the International Affective Picture System (IAPS). Eighteen right-handed volunteer students from North-Eastern University participated in the experiment. Electrode from the frontal site (F3 and F4), C3 and C4 (central electrodes), P3 andP4 (parietal electrodes) and O1 and O2 (occipital electrodes) were averaged with the stimuli type and brain hemisphere. The change in spectral power of the brain signal and its main spectral bands of theta (3-7.5 Hz), Alpha (7.5-13 Hz) and Beta (13-25 Hz) were analyzed. Erotic stimuli showed ERP components deflected more negatively at the frontal electrode site than the negative picture stimuli during the time window of 200-300 ms whereas the negative valence stimuli processing reflected a positively twisted amplitude at the time window of 120-300 ms. The erotic and negative valence emotional picture stimuli show a significant difference in the spectral power of theta, alpha and beta frequency bands for the left vs. right hemisphere and frontal vs. occipital sites. Nonetheless, the time-frequency plots show us those emotionally valence visual stimuli triggered an increase of alpha band (7.5-13 Hz).
{"title":"Assessing Neural Oscillations during Erotic and Negative Emotional Pictures Viewing: An Event-Related Potential Study","authors":"Fetlework Tenssay","doi":"10.36648/2171-6625.12.1.350","DOIUrl":"https://doi.org/10.36648/2171-6625.12.1.350","url":null,"abstract":"The present study was designed to determine whether or not there are components of the ERPs that discriminate the erotic and negative pictures during affective picture processing. Participants viewed erotic, negative and neutral pictures form the International Affective Picture System (IAPS). Eighteen right-handed volunteer students from North-Eastern University participated in the experiment. Electrode from the frontal site (F3 and F4), C3 and C4 (central electrodes), P3 andP4 (parietal electrodes) and O1 and O2 (occipital electrodes) were averaged with the stimuli type and brain hemisphere. The change in spectral power of the brain signal and its main spectral bands of theta (3-7.5 Hz), Alpha (7.5-13 Hz) and Beta (13-25 Hz) were analyzed. Erotic stimuli showed ERP components deflected more negatively at the frontal electrode site than the negative picture stimuli during the time window of 200-300 ms whereas the negative valence stimuli processing reflected a positively twisted amplitude at the time window of 120-300 ms. The erotic and negative valence emotional picture stimuli show a significant difference in the spectral power of theta, alpha and beta frequency bands for the left vs. right hemisphere and frontal vs. occipital sites. Nonetheless, the time-frequency plots show us those emotionally valence visual stimuli triggered an increase of alpha band (7.5-13 Hz).","PeriodicalId":91329,"journal":{"name":"Journal of neurology and neuroscience","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69698974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.36648/2171-6625.21.12.382
Pop-Jordanova Nada, Poppenk Jordan
The main question in neuroscience is how the material tissue (brain) is producing the non-material phenomena (mind; thought, memory, emotions). Recent advancements in the brain sciences have enabled researchers to determine locations and patterns of neural activation associated with various psychological functions. Still, the mind-brain puzzle is complex and not yet elucidate. The fundamental relevance of EEG spectra for mental activation (both, general and focused) can be related to the interaction of electric field with neuronal quantum dipoles. The obtained analytical expressions and numerical values based on quantum transition probabilities correspond to classical empirical results for arousal and attention, including the characteristic frequency dependence and intervals. This paper proposes a theoretical approach to explain the characteristic empirical interdependence between the states of arousal (representing the level of consciousness) and EEG activity. Consequently, we introduced mathematical formula to calculate field-dipole interactions, which corresponds to clinical states and can be considered as an integral brain state attribute, correlated to its electric, mental and metabolic activity. The article is a compilation of some our related articles, published before. There is a substantial distinction between the coarsegrained arousal (as background state of consciousness) and the fine-grained content of consciousness, whereby attention appears to be a bridge. However, deeper understanding of substrates and emergence of arousal, attention and consciousness must take into account the subtle interplay of neurophysical, neurochemical and neurobiological correlates.
{"title":"How Brain Creates the Mind? Recent Advancements in the Brain Science","authors":"Pop-Jordanova Nada, Poppenk Jordan","doi":"10.36648/2171-6625.21.12.382","DOIUrl":"https://doi.org/10.36648/2171-6625.21.12.382","url":null,"abstract":"The main question in neuroscience is how the material tissue (brain) is producing the non-material phenomena (mind; thought, memory, emotions). Recent advancements in the brain sciences have enabled researchers to determine locations and patterns of neural activation associated with various psychological functions. Still, the mind-brain puzzle is complex and not yet elucidate. The fundamental relevance of EEG spectra for mental activation (both, general and focused) can be related to the interaction of electric field with neuronal quantum dipoles. The obtained analytical expressions and numerical values based on quantum transition probabilities correspond to classical empirical results for arousal and attention, including the characteristic frequency dependence and intervals. This paper proposes a theoretical approach to explain the characteristic empirical interdependence between the states of arousal (representing the level of consciousness) and EEG activity. Consequently, we introduced mathematical formula to calculate field-dipole interactions, which corresponds to clinical states and can be considered as an integral brain state attribute, correlated to its electric, mental and metabolic activity. The article is a compilation of some our related articles, published before. There is a substantial distinction between the coarsegrained arousal (as background state of consciousness) and the fine-grained content of consciousness, whereby attention appears to be a bridge. However, deeper understanding of substrates and emergence of arousal, attention and consciousness must take into account the subtle interplay of neurophysical, neurochemical and neurobiological correlates.","PeriodicalId":91329,"journal":{"name":"Journal of neurology and neuroscience","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69700365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.36648/2171-6625.21.12.380
F. Marcu
Background: Multiple sclerosis, characterized by demyelination or loss of myelin sheaths affects the discharge of nerve impulses and the ability of the central nervous system CNS, to transmit commands, resulting in disorders of functions that are directed by the CNS such as: sight, speech, walking, writing and memory. Depending on the location of the demyelination, patients have a wide range of symptoms that differ from person to person and may change as the condition progresses. The most common symptoms are: fatigue, balance and coordination disorders, vision and sensitivity disorders, pain and depression. Objective: In this study we aimed to demonstrate that the treatment of sclerosis by combining a drug treatment with a rehabilitation treatment, represented by physical therapy and occupational therapy, has superior therapeutic effects compared to simple drug treatment. Methods: In order to highlight the superior therapeutic efficacy of the mentioned combination, we studied, during one year, two groups of patients: the group that respects the home rehabilitation program and the group that does not respect the home rehabilitation program. In our study, we evaluated the following parameters: number of patients with falls, timed 25-Foot Walk and Multiple Sclerosis Quality of Life-54. Results: The results of our study highlight the superior therapeutic benefits of drug treatment associated with rehabilitation treatment. Conclusion: Patients who follow the rehabilitation program associated with drug treatment we found the following benefits: improving body stability; increase in muscle strength in the lower limbs; improving coordination and balance while walking; improving the QoL.
{"title":"The Benefits of the Rehabilitation Program in Multiple Sclerosis","authors":"F. Marcu","doi":"10.36648/2171-6625.21.12.380","DOIUrl":"https://doi.org/10.36648/2171-6625.21.12.380","url":null,"abstract":"Background: Multiple sclerosis, characterized by demyelination or loss of myelin sheaths affects the discharge of nerve impulses and the ability of the central nervous system CNS, to transmit commands, resulting in disorders of functions that are directed by the CNS such as: sight, speech, walking, writing and memory. Depending on the location of the demyelination, patients have a wide range of symptoms that differ from person to person and may change as the condition progresses. The most common symptoms are: fatigue, balance and coordination disorders, vision and sensitivity disorders, pain and depression. Objective: In this study we aimed to demonstrate that the treatment of sclerosis by combining a drug treatment with a rehabilitation treatment, represented by physical therapy and occupational therapy, has superior therapeutic effects compared to simple drug treatment. Methods: In order to highlight the superior therapeutic efficacy of the mentioned combination, we studied, during one year, two groups of patients: the group that respects the home rehabilitation program and the group that does not respect the home rehabilitation program. In our study, we evaluated the following parameters: number of patients with falls, timed 25-Foot Walk and Multiple Sclerosis Quality of Life-54. Results: The results of our study highlight the superior therapeutic benefits of drug treatment associated with rehabilitation treatment. Conclusion: Patients who follow the rehabilitation program associated with drug treatment we found the following benefits: improving body stability; increase in muscle strength in the lower limbs; improving coordination and balance while walking; improving the QoL.","PeriodicalId":91329,"journal":{"name":"Journal of neurology and neuroscience","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69700598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.36648/2171-6625.21.12.384
Supreeth N Gowda
Mycotic Aneurysm (MA), a rare complication of systemic infections, is a result of degradation and dilation of the arterial wall. Etiology can be due to endovascular seeding of infective emboli (e.g. infective endocarditis, bacteremia) or extravascular spread of infection (e.g. meningitis, osteomyelitis, orbital cellulitis). Infective Intracranial Aneurysms (IIA) is extremely rare and account for a small fraction of all intracranial aneurysms. Most IIA are caused by bacterial or fungal infections. IIA has a higher risk of rupture as compared to other aneurysms due to their rapid progression and increased vessel fragility. Diagnosis is mostly based on clinical history and neurovascular imaging. Medical management and endovascular intervention can be considered the first-line treatment for unruptured IIA. Open surgery is done in cases of complications or failed endovascular intervention. A case of suspected ruptured IIA secondary to bacterial meningitis is discussed in detail along with a review of the literature. Certain proposals on diagnosis, management, and complication have been put forth.
{"title":"Ruptured Infective (Mycotic) Intracranial Aneurysm Secondary to Bacterial Meningitis: A Case Report and Review of Literature","authors":"Supreeth N Gowda","doi":"10.36648/2171-6625.21.12.384","DOIUrl":"https://doi.org/10.36648/2171-6625.21.12.384","url":null,"abstract":"Mycotic Aneurysm (MA), a rare complication of systemic infections, is a result of degradation and dilation of the arterial wall. Etiology can be due to endovascular seeding of infective emboli (e.g. infective endocarditis, bacteremia) or extravascular spread of infection (e.g. meningitis, osteomyelitis, orbital cellulitis). Infective Intracranial Aneurysms (IIA) is extremely rare and account for a small fraction of all intracranial aneurysms. Most IIA are caused by bacterial or fungal infections. IIA has a higher risk of rupture as compared to other aneurysms due to their rapid progression and increased vessel fragility. Diagnosis is mostly based on clinical history and neurovascular imaging. Medical management and endovascular intervention can be considered the first-line treatment for unruptured IIA. Open surgery is done in cases of complications or failed endovascular intervention. A case of suspected ruptured IIA secondary to bacterial meningitis is discussed in detail along with a review of the literature. Certain proposals on diagnosis, management, and complication have been put forth.","PeriodicalId":91329,"journal":{"name":"Journal of neurology and neuroscience","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69700766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.36648/2171-6625.21.10.376
F. Villarejo, B. Mansilla, M. Budke
Objective: Vertebral compression fractures (VCF) cause significant disability and pain and are usually treated by vertebroplasty using polymethylmethacrylate (PMMA), which has several drawbacks, including fractures and exothermic neural damage associated to lea-kage. VK100 silicone is a new polymer for vertebroplasty to resolve these disadvantages. Material and Methods: This study follows the evolution of seventy patients with VCF who received a VK100 elastoplasty. The period of follow up was a year average. Results: Four patients had asymptomatic silicone leakage, none had neural damage and, at the end of follow up, there had been no adjacent fractures. Patients reported less pain. Conclusion: We conclude VK100 is a good option for vertebroplasty to treat osteoporotic spinal compression fractures.
{"title":"Elastoplasty: A New Technique for Treatment of steoporotic Vertebral Compression Fractures","authors":"F. Villarejo, B. Mansilla, M. Budke","doi":"10.36648/2171-6625.21.10.376","DOIUrl":"https://doi.org/10.36648/2171-6625.21.10.376","url":null,"abstract":"Objective: Vertebral compression fractures (VCF) cause significant disability and pain and are usually treated by vertebroplasty using polymethylmethacrylate (PMMA), which has several drawbacks, including fractures and exothermic neural damage associated to lea-kage. VK100 silicone is a new polymer for vertebroplasty to resolve these disadvantages. Material and Methods: This study follows the evolution of seventy patients with VCF who received a VK100 elastoplasty. The period of follow up was a year average. Results: Four patients had asymptomatic silicone leakage, none had neural damage and, at the end of follow up, there had been no adjacent fractures. Patients reported less pain. Conclusion: We conclude VK100 is a good option for vertebroplasty to treat osteoporotic spinal compression fractures.","PeriodicalId":91329,"journal":{"name":"Journal of neurology and neuroscience","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69699911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.36648/2171-6625.12.1.348
Ashwaq Alsulami, A. Khoja, Mohammad Alsumaili, Mohamed Alkhaja, M. Al-Khateeb
Electroencephalography with video monitoring (VEEG) is considered the gold standard for differentiating epileptic from non-epileptic events. The standardization of length of hospital stay (LOS) in the Epilepsy Monitoring Unit (EMU) setting is challenging due to the paroxysmal nature of seizures. This study evaluates the factors contributing to the LOS and days of VEEG recording with the EMU final diagnosis and plan. A retrospective study was conducted on inpatients admitted to the EMU, at a tertiary center from January to December 2016. All consecutive patients admitted to EMU during the study period were included. A total of 160 patients were enrolled. The mean age was 21.10 years (SD 13.33). Upon discharge, most of the patients were diagnosed with epileptic seizures, of whom 91 (56.9%) had focal seizures, and 30 (18.8%) had generalized epilepsy. Patient who stayed in the EMU>12 days required 6-10 days of VEEG recording to reach the diagnosis. Patients who had the surgical plan as a discharge diagnosis were significant to have a prolonged length of stay>12 days. Six to ten days of EEG recording were significant to diagnose focal seizures in 44 (60.3%). Patients were concluded to have a surgical plan (resective surgery), focal seizures and Attention Deficit Hyperactivity Disorder (ADHD) as a comorbidity are all significantly associated with a prolonged length of stay. Our findings suggest that factors affecting the length of hospital stay or period of EEG recording during the admission should be considered when planning EMU admissions.
{"title":"Factors Contributing to the Length of Stay in Patients Admitted to the Epilepsy Monitoring Unit","authors":"Ashwaq Alsulami, A. Khoja, Mohammad Alsumaili, Mohamed Alkhaja, M. Al-Khateeb","doi":"10.36648/2171-6625.12.1.348","DOIUrl":"https://doi.org/10.36648/2171-6625.12.1.348","url":null,"abstract":"Electroencephalography with video monitoring (VEEG) is considered the gold standard for differentiating epileptic from non-epileptic events. The standardization of length of hospital stay (LOS) in the Epilepsy Monitoring Unit (EMU) setting is challenging due to the paroxysmal nature of seizures. This study evaluates the factors contributing to the LOS and days of VEEG recording with the EMU final diagnosis and plan. A retrospective study was conducted on inpatients admitted to the EMU, at a tertiary center from January to December 2016. All consecutive patients admitted to EMU during the study period were included. A total of 160 patients were enrolled. The mean age was 21.10 years (SD 13.33). Upon discharge, most of the patients were diagnosed with epileptic seizures, of whom 91 (56.9%) had focal seizures, and 30 (18.8%) had generalized epilepsy. Patient who stayed in the EMU>12 days required 6-10 days of VEEG recording to reach the diagnosis. Patients who had the surgical plan as a discharge diagnosis were significant to have a prolonged length of stay>12 days. Six to ten days of EEG recording were significant to diagnose focal seizures in 44 (60.3%). Patients were concluded to have a surgical plan (resective surgery), focal seizures and Attention Deficit Hyperactivity Disorder (ADHD) as a comorbidity are all significantly associated with a prolonged length of stay. Our findings suggest that factors affecting the length of hospital stay or period of EEG recording during the admission should be considered when planning EMU admissions.","PeriodicalId":91329,"journal":{"name":"Journal of neurology and neuroscience","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69699327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.36648/2171-6625.21.12.358
Dorokhov Ad, Shkilnyuk Gg, Stolyarov Id, K. K. Mineev, Ivashkova Ev, Malikh Aa, TartakovskiyVN, Kryukova Ev, Tcvetkova Tl
Multiple sclerosis (MS) is on the second place after epilepsy in the young people fourth place among the neurological diseases of central nervous system. The main feature of the up-to-date MS therapy is the individual approach to the patient. Interest to the monitoring of the individual load in the daily activity is tremendously increased the last years. The purpose of this research was to demonstrate the possibility of the loading monitoring in the MS patients with a help of special measurement insoles and mobile application (both iOS and Android), allowing calculating not only the number of steps, but also the total loading, contact time, foot contact areas, imbalance, and cadence. Comparison of 2 patients with the same MS type and the same therapy was performed. Both patients are males, differ by age and body mass index, with no disability (minimal disability in 2 functional systems). Application of up-to-date measurement devices and mobile application allows to estimate the daily patient activity as well as the other parameters characterizing the gait pattern and its impairments. Functional diagnostics during barefoot platform measurements and influence of the shoes in in-shoe measurements give the opportunity to assume the limitation of physical activity in persons with MS.
{"title":"Physical Activity Assessment in Patients with Multiple Sclerosis","authors":"Dorokhov Ad, Shkilnyuk Gg, Stolyarov Id, K. K. Mineev, Ivashkova Ev, Malikh Aa, TartakovskiyVN, Kryukova Ev, Tcvetkova Tl","doi":"10.36648/2171-6625.21.12.358","DOIUrl":"https://doi.org/10.36648/2171-6625.21.12.358","url":null,"abstract":"Multiple sclerosis (MS) is on the second place after epilepsy in the young people fourth place among the neurological diseases of central nervous system. The main feature of the up-to-date MS therapy is the individual approach to the patient. Interest to the monitoring of the individual load in the daily activity is tremendously increased the last years. The purpose of this research was to demonstrate the possibility of the loading monitoring in the MS patients with a help of special measurement insoles and mobile application (both iOS and Android), allowing calculating not only the number of steps, but also the total loading, contact time, foot contact areas, imbalance, and cadence. Comparison of 2 patients with the same MS type and the same therapy was performed. Both patients are males, differ by age and body mass index, with no disability (minimal disability in 2 functional systems). Application of up-to-date measurement devices and mobile application allows to estimate the daily patient activity as well as the other parameters characterizing the gait pattern and its impairments. Functional diagnostics during barefoot platform measurements and influence of the shoes in in-shoe measurements give the opportunity to assume the limitation of physical activity in persons with MS.","PeriodicalId":91329,"journal":{"name":"Journal of neurology and neuroscience","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69700037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.36648/2171-6625.21.12.386
Raghav Kapoor, Sumeet Roy, G. Nikita, R. Saini
A brain infarct is a tissue death due to inadequate blood supply to the affected area. While large or massive infarcts present with a very vague motor symptom, small thalamic infarcts can present with a variety of sensory deficits that can be difficult to diagnose clinically because of their seemingly disconnected manifestations. Cheiro-oral Syndrome is a pure sensory deficit which is confined to the perioral region and ipsilateral distal fingers. This very subtle clinical presentation might be missed in acute settings. We are reporting a case of a 46-year-old who was admitted with the complaints of peri-oral numbness on right side associated with weakness in right upper limb and lower limb.
{"title":"Cheiro-Oral syndrome due to Acute Lacunar Thalamic Infarct","authors":"Raghav Kapoor, Sumeet Roy, G. Nikita, R. Saini","doi":"10.36648/2171-6625.21.12.386","DOIUrl":"https://doi.org/10.36648/2171-6625.21.12.386","url":null,"abstract":"A brain infarct is a tissue death due to inadequate blood supply to the affected area. While large or massive infarcts present with a very vague motor symptom, small thalamic infarcts can present with a variety of sensory deficits that can be difficult to diagnose clinically because of their seemingly disconnected manifestations. Cheiro-oral Syndrome is a pure sensory deficit which is confined to the perioral region and ipsilateral distal fingers. This very subtle clinical presentation might be missed in acute settings. We are reporting a case of a 46-year-old who was admitted with the complaints of peri-oral numbness on right side associated with weakness in right upper limb and lower limb.","PeriodicalId":91329,"journal":{"name":"Journal of neurology and neuroscience","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69700398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.36648/2171-6625.21.12.383
A. Manga
The goal of this research is to test which parts of the brain hydrotherapy triggers and the behaviours linked to each part of the brain. There has been extensive research on potential drugs that can benefit Autism, including Risperidone and Balovaptan, as well as music therapy. Hydrotherapy is a fairly novel therapy idea, and there has been some research conducted on the effectiveness of this therapy without accounting for the functionality of the child. Therefore, this research aims to determine which parts of the brain will receive blood flow, measured by fMRI, following hydrotherapy and which level of Autism Spectrum Disorder (Autistic Disorder, Asperger’s Syndrome and Pervasive Developmental Disorder) will experience the greatest benefits.
{"title":"A Study of How Hydrotherapy Affects the Brain and Its Effectiveness on Children with Varying Levels of Autism Spectrum Disorder","authors":"A. Manga","doi":"10.36648/2171-6625.21.12.383","DOIUrl":"https://doi.org/10.36648/2171-6625.21.12.383","url":null,"abstract":"The goal of this research is to test which parts of the brain hydrotherapy triggers and the behaviours linked to each part of the brain. There has been extensive research on potential drugs that can benefit Autism, including Risperidone and Balovaptan, as well as music therapy. Hydrotherapy is a fairly novel therapy idea, and there has been some research conducted on the effectiveness of this therapy without accounting for the functionality of the child. Therefore, this research aims to determine which parts of the brain will receive blood flow, measured by fMRI, following hydrotherapy and which level of Autism Spectrum Disorder (Autistic Disorder, Asperger’s Syndrome and Pervasive Developmental Disorder) will experience the greatest benefits.","PeriodicalId":91329,"journal":{"name":"Journal of neurology and neuroscience","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69700404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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