Botanics : targets and therapy最新文献_第2页

Cranberry products in the prevention of urinary tract infections: examining the evidence 蔓越莓产品在预防尿路感染中的作用:检验证据

Botanics : targets and therapy

Pub Date : 2015-07-14 DOI: 10.2147/BTAT.S62986

R. Nowack, R. Birck

License. The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on how to request permission may be found at: http://www.dovepress.com/permissions.php Botanics: Targets and Therapy 2015:5 45–54 Botanics: Targets and Therapy Dovepress

许可证。许可的完整条款可在http://creativecommons.org/licenses/by-nc/3.0/上获得。允许非商业用途的工作，没有任何进一步的许可，从多芬医学出版社有限公司，只要工作适当署名。超出许可范围的许可由多芬医疗新闻有限公司管理。有关如何请求许可的信息可在以下网站找到:http://www.dovepress.com/permissions.php Botanics: Targets and Therapy 2015:5 45-54 Botanics: Targets and Therapy Dovepress

引用次数: 4

Toward the integration and advancement of herbal medicine: a focus on traditional Indian medicine 走向草药的整合与进步:以印度传统医学为重点

Botanics : targets and therapy

Pub Date : 2015-02-13 DOI: 10.2147/BTAT.S66308

S. Sen, R. Chakraborty

Indian traditional codified medicinal systems and folk medicine are a vast lexicon of herbal formulations and medicinal plants. In last few decades, the popularity of herbal medicine/ products has increased worldwide, not only as part of conventional treatment strategies but also for health care management, and thus the opportunity to promote Indian traditional medicine is increasing globally. Recently people from several developed and developing countries have been attracted toward traditional Indian herbal medicines. A large number of modern medi- cines are derived from the plants used in Ayurveda and other traditional medicinal systems. Ayurveda and other traditional herbal medicines are capable of addressing some modern unmet medical needs, and can provide the basis for developing potential medicines. Lack of drug standardization, information, quality control, and strict monitoring are the primary lacunae in the promotion of traditional Indian herbal products. In recent years several regulatory and promotional approaches have been undertaken to overcome such problems. Quality control, rigorous research to establish the effectiveness and safety, and credible clinical trials of the herbal products are required. Thus the careful and scientific integration of Indian traditional herbal medicine into evidence-based clinical management of diseases is essential to provide better health care facilities to people.

印度传统的法典医疗系统和民间医学是一个庞大的草药配方和药用植物词典。在过去的几十年里，草药/产品的受欢迎程度在全球范围内增加，不仅作为传统治疗策略的一部分，而且作为卫生保健管理的一部分，因此在全球范围内推广印度传统医学的机会正在增加。最近，一些发达国家和发展中国家的人们被传统的印度草药所吸引。大量的现代药物是从阿育吠陀和其他传统医药系统中使用的植物中提取的。阿育吠陀和其他传统草药能够解决一些现代未满足的医疗需求，并可以为开发潜在药物提供基础。缺乏药品标准化、信息、质量控制和严格监测是传统印度草药产品推广的主要空白。近年来采取了若干管制和促进办法来克服这些问题。需要进行质量控制，严格的研究以确定草药产品的有效性和安全性，以及可靠的临床试验。因此，谨慎和科学地将印度传统草药纳入循证临床疾病管理，对于向人们提供更好的卫生保健设施至关重要。

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引用次数: 57

Genistein reduces angiogenesis and apoptosis in women with endometrial hyperplasia 染料木素可减少子宫内膜增生的血管生成和细胞凋亡

Botanics : targets and therapy

Pub Date : 2015-01-27 DOI: 10.2147/BTAT.S67368

R. Granese, A. Bitto, F. Polito, O. Triolo, D. Giordano, A. Santamaria, F. Squadrito, R. D’Anna

Endometrial hyperplasia without cytological atypia is commonly treated with pro- gestins, but other treatments may be available with equivalent efficacy and reduced side effects. Here, we evaluate the effect of genistein aglycone on angiogenesis and apoptosis-related markers women with endometrial hyperplasia. Premenopausals (n=38) with nonatypical endometrial hyperplasia were administered either genistein aglycone (54 mg/day, n=19) or norethisterone acetate (10 mg/day, n=19) on days 16-25 of the menstrual cycle and evaluated for 6 months. Biopsies were taken during hysteroscopy at baseline and 6 months, and symptoms including excessive uterine bleeding were assessed at baseline and 3 and 6 months following recruitment. The expression of angiogenesis (Vegf), epithelial (Egf and Tgfb), and apoptosis-related (Bax, Bcl-2, and Casp-9) molecules, were assessed in uterine biopsies at baseline and after 6 months of therapy. Follicle-stimulating hormone, luteinizing hormone, estradiol, SHBG, and progesterone levels were also measured. After 6 months, 42% of genistein aglycone-administered patients had a significant improvement of symptoms compared to 47% of norethisterone acetate subjects. No significant differences were noted in hormone levels for any treatment. Gene expression revealed a significant reduction in Vegf , Egf, and Tgfb (P,0.05 versus baseline), and an increase in proapoptotic molecules (Bax and Casp-9), with a concomitant decrease in Bcl-2 values (P,0.05) in both groups. These results suggest that genistein aglycone might be useful for the management of endometrial hyperplasia without atypia in women who cannot or do not wish to be treated with progestin.

无细胞学异型性的子宫内膜增生通常用孕激素治疗，但其他治疗方法可能具有相同的疗效和更少的副作用。在这里，我们评估染料木素苷元对子宫内膜增生女性血管生成和细胞凋亡相关标志物的影响。非典型子宫内膜增生的绝经前患者(n=38)在月经周期的第16-25天给予染料木素苷元(54 mg/天，n=19)或醋酸去甲睾酮(10 mg/天，n=19)，并评估6个月。在基线和6个月宫腔镜检查期间进行活检，在基线和招募后3个月和6个月评估包括子宫过度出血在内的症状。在基线和治疗6个月后的子宫活检中评估血管生成(Vegf)、上皮(Egf和Tgfb)和凋亡相关(Bax、Bcl-2和Casp-9)分子的表达。同时测定促卵泡激素、黄体生成素、雌二醇、SHBG和孕酮水平。6个月后，42%服用染料木素苷元的患者症状明显改善，而47%服用醋酸去甲睾酮的患者症状明显改善。两种治疗方法的激素水平均无显著差异。基因表达显示Vegf、Egf和Tgfb显著降低(与基线相比P,0.05)，促凋亡分子(Bax和Casp-9)增加，同时Bcl-2值降低(P,0.05)。这些结果表明染料木素苷元可能是有用的管理子宫内膜增生无异型的妇女不能或不希望用黄体酮治疗。

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引用次数: 9

Profile of crofelemer for the symptomatic treatment of diarrhea in HIV-infected persons crofelemer对症治疗hiv感染者腹泻的概况

Botanics : targets and therapy

Pub Date : 2015-01-07 DOI: 10.2147/BTAT.S42267

C. Leonard, P. Chordia, R. MacArthur

License. The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on how to request permission may be found at: http://www.dovepress.com/permissions.php Botanics: Targets and Therapy 2015:5 21–25 Botanics: Targets and Therapy Dovepress

许可证。许可的完整条款可在http://creativecommons.org/licenses/by-nc/3.0/上获得。允许非商业用途的工作，没有任何进一步的许可，从多芬医学出版社有限公司，只要工作适当署名。超出许可范围的许可由多芬医疗新闻有限公司管理。有关如何请求许可的信息可在以下网站找到:http://www.dovepress.com/permissions.php Botanics: Targets and Therapy 2015:5 21-25 Botanics: Targets and Therapy Dovepress

引用次数: 3

Recent perspectives on the anticancer properties of aqueous extracts of Nigerian Vernonia amygdalina. 尼日利亚 Vernonia amygdalina 水提取物抗癌特性的最新展望。

Botanics : targets and therapy

Pub Date : 2015-01-01 Epub Date: 2015-11-30 DOI: 10.2147/BTAT.S62984

Carolyn Bingham Howard, William K Johnson, Shehla Pervin, Ernest B Izevbigie

Innovative developments are necessary for treating and defeating cancer, an oftentimes deadly group of diseases characterized by the uncontrolled growth and spread of abnormal cells. Breast cancer (BC) is the second leading cause of cancer-related deaths of women in the USA, and prostate cancer (PC) is the second leading cause of cancer-related deaths of American men. Although some efficacious BC drugs are pharmaceutically marketed, they affect the quality of life for some patients because they are toxic in that their usages have been accompanied by side effects such as stroke, thrombosis, slow heart rate, seizure, increased blood pressure, nausea, emesis, and more. Therefore, there is an urgent need for the discovery of molecular markers for early detection of this disease and discovery of targets for the development of novel, less toxic therapeutics. A botanical plant Vernonia amygdalina has been widely used in Nigerian and other Central and West African cultures for centuries as an herbal medicine. Mounting evidence suggests that treatment with low concentrations of aqueous leaf extracts of the edible Nigerian V. amygdalina plant (Niger-VA) arrests the proliferative activities and induces apoptosis in estrogen receptor-positive, estrogen receptor-negative, and triple-negative human breast cancerous cells and in androgen-independent human PC-3. Also, in athymic mice, Niger-VA potentiates increased efficacies and optimizes treatment outcomes when given as a cotreatment with conventional chemotherapy drugs. Evidence of its noticeable cytostatic activities ranging from changes in DNA synthesis to growth inhibition, mechanisms of inducing apoptosis in different cancer cell lines, and in vivo antitumorigenic activities and chemopreventive efficacy reinforce the idea that Niger-VA deserves increased attention for further development as a phytoceutical, anticancer drug entity. Hence, the present review article highlights impactful published literature on the anticancer effects of Niger-VA in multiple cancerous cell lines and in a nude mouse model, supporting its potential usefulness as a natural product, chemotherapeutic medicine for treatment of both BC and PC.

癌症是一类常常致命的疾病，其特点是异常细胞不受控制地生长和扩散。乳腺癌（BC）是美国女性癌症相关死亡的第二大原因，而前列腺癌（PC）则是美国男性癌症相关死亡的第二大原因。虽然一些有效的乳腺癌药物已在市场上销售，但它们影响了一些患者的生活质量，因为这些药物具有毒性，使用时会出现中风、血栓形成、心率减慢、癫痫发作、血压升高、恶心、呕吐等副作用。因此，迫切需要发现早期检测这种疾病的分子标记，并发现开发新型、低毒性治疗药物的靶点。几个世纪以来，一种植物 Vernonia amygdalina 作为草药在尼日利亚及其他中非和西非文化中被广泛使用。越来越多的证据表明，用低浓度的可食用的尼日利亚 V. amygdalina 植物（尼日尔-VA）水叶提取物处理雌激素受体阳性、雌激素受体阴性和三阴性人类乳腺癌细胞以及雄激素依赖性人类 PC-3 细胞，可阻止其增殖活动并诱导其凋亡。此外，在无胸腺小鼠体内，尼日尔-VA 与传统化疗药物共同治疗时，可增强疗效并优化治疗结果。尼日尔-VA明显的细胞抑制活性（从DNA合成变化到生长抑制）、诱导不同癌细胞株凋亡的机制、体内抗肿瘤活性和化学预防功效，这些证据强化了尼日尔-VA作为一种植物抗癌药物实体值得进一步开发的观点。因此，本综述文章重点介绍了已发表的有关尼日尔-VA 在多种癌细胞系和裸鼠模型中的抗癌作用的重要文献，支持尼日尔-VA 作为一种天然产品和化疗药物在治疗 BC 和 PC 方面的潜在用途。

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引用次数: 0

Efficacy and safety of plant-derived products for the treatment of osteoarthritis 植物源性产品治疗骨关节炎的疗效和安全性

Botanics : targets and therapy

Pub Date : 2014-12-16 DOI: 10.2147/BTAT.S33431

L. Laslett, Xingzhong Jin, G. Jones

Background: Plant-derived therapies are traditionally used as medicines, but they have generally not been studied with the same rigor as pharmaceutical agents. This review summarizes the use of plant-derived products for osteoarthritis. Methods: Sixty-three identified trials were summarized for pain, function, and safety outcomes using standardized mean differences (SMDs) and relative risks. Results: Plant-derived therapies are effective for treating pain compared to placebo, as assessed using visual analog scores and numerical rating scales (SMD, 1.08; 95% confidence interval [CI]: 0.72–1.44), or Western Ontario and McMaster University Osteoarthritis Index (WOMAC)/Knee injury and Osteoarthritis Outcome Score (KOOS) pain scales (SMD, 0.98; 95% CI: 0.62–1.35). Classes demonstrating overall efficacy in more than one trial for either visual analog scores or WOMAC pain included Boswellia serrata, capsaicin, and ginger; there was single-trial evidence of the efficacy of another nine agents. Plant-derived therapies have similar efficacy to an active comparator (SMD, 0.32; P = 0.08; -0.08; P = 0.14). Therapies are also effective for functional outcomes compared to placebo (SMD, 0.92; P = Conclusion: Plant-derived therapies may be efficacious in treating osteoarthritic pain and functional limitations, and they appear to be safer than other active therapies. However, quality trials and long-term data are lacking, and the number of trials for each therapy is limited. Comparisons would be assisted by trial standardization.

背景:植物源性疗法传统上被用作药物，但它们通常没有像药物制剂那样得到严格的研究。本文综述了植物源性产品治疗骨关节炎的应用。方法:采用标准化平均差异(SMDs)和相对风险对63项确定的试验的疼痛、功能和安全性结果进行总结。结果:与安慰剂相比，植物源性疗法在治疗疼痛方面是有效的，使用视觉模拟评分和数值评定量表(SMD, 1.08;95%可信区间[CI]: 0.72-1.44)，或西安大略和麦克马斯特大学骨关节炎指数(WOMAC)/膝关节损伤和骨关节炎结局评分(oos)疼痛量表(SMD, 0.98;95% ci: 0.62-1.35)。在一个以上的试验中对视觉模拟评分或WOMAC疼痛表现出总体疗效的类别包括锯齿状乳香菌、辣椒素和生姜;还有另外九种药物的疗效的单次试验证据。植物源性疗法的疗效与活性比较物相似(SMD, 0.32;p = 0.08;-0.08;p = 0.14)。与安慰剂相比，治疗对功能结局也有效(SMD, 0.92;P =结论:植物源性疗法可能对治疗骨关节炎疼痛和功能限制有效，并且它们似乎比其他积极疗法更安全。然而，缺乏高质量的试验和长期数据，每种疗法的试验数量有限。试验标准化将有助于比较。

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引用次数: 3

Myths and facts in herbal medicines: Eleutherococcus senticosus (Siberian ginseng) and its contraindication in hypertensive patients 草药中的神话与事实:敏感棘球菌(西伯利亚人参)及其在高血压患者中的禁忌症

Botanics : targets and therapy

Pub Date : 2014-07-18 DOI: 10.2147/BTAT.S60734

Mathias Schmidt, M. Thomsen, O. Kelber, K. Kraft

License. The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on how to request permission may be found at: http://www.dovepress.com/permissions.php Botanics: Targets and Therapy 2014:4 27–32 Botanics: Targets and Therapy Dovepress

许可证。许可的完整条款可在http://creativecommons.org/licenses/by-nc/3.0/上获得。允许非商业用途的工作，没有任何进一步的许可，从多芬医学出版社有限公司，只要工作适当署名。超出许可范围的许可由多芬医疗新闻有限公司管理。有关如何请求许可的信息可在以下网址找到:http://www.dovepress.com/permissions.php Botanics: Targets and Therapy 2014:4 27-32 Botanics: Targets and Therapy Dovepress

引用次数: 10

Botanics: a potential source of new therapies for Alzheimer's disease? 植物学:阿尔茨海默病新疗法的潜在来源?

Botanics : targets and therapy

Pub Date : 2014-04-03 DOI: 10.2147/BTAT.S33554

Arif Nisha Syad, K. P. Devi

: Alzheimer’s disease is an age-related, complex neurodegenerative disorder characterized by loss of memory and impairment of multiple cognitive functions. Several factors contribute to the progression and development of the disease including amyloid beta accumulation, neurofibrillary tangle formation, cholinergic deficit, oxidative stress, neuroinflammation, and apoptosis. Numerous traditional and herbal medicinal plants have been used to treat several cognitive disorders including Alzheimer’s disease. They act as excellent antioxidants, anti-inflammatory mediators, and cholinesterase and β -secretase inhibitors. In addition, these natural compounds also prevent the accumulation of amyloid beta and its fibril formation. Besides acting as core-molecules, these natural compounds act as a template for the production and synthesis of several drug leads with improved pharmacokinetic potentials and greater efficacies. Hence, herbal medicines that have interesting pharmacological effects with noticeable anti-Alzheimer’s potential deserve increased attention for further development to drug entities. The present article reviews the botanical pharmacology with special reference to anti-Alzheimer activity of plants and plant-derived compounds.

阿尔茨海默病是一种与年龄相关的复杂神经退行性疾病，其特征是记忆丧失和多种认知功能受损。多种因素导致疾病的进展和发展，包括淀粉样蛋白积累、神经原纤维缠结形成、胆碱能缺陷、氧化应激、神经炎症和细胞凋亡。许多传统和草药植物已被用于治疗包括阿尔茨海默病在内的几种认知障碍。它们是极好的抗氧化剂，抗炎介质，以及胆碱酯酶和β分泌酶抑制剂。此外，这些天然化合物还能防止淀粉样蛋白的积累及其纤维的形成。除了作为核心分子外，这些天然化合物还作为几种药物先导物的生产和合成模板，具有更好的药代动力学电位和更高的功效。因此，具有显著抗阿尔茨海默病潜力的有趣药理作用的草药值得进一步关注，以进一步开发药物实体。本文综述了植物药理学的研究进展，重点介绍了植物及其衍生化合物的抗阿尔茨海默病活性。

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引用次数: 27

Update on the efficacy and safety of Petadolex ® , a butterbur extract for migraine prophylaxis 用于预防偏头痛的butterbur提取物Petadolex®的有效性和安全性的最新进展

Botanics : targets and therapy

Pub Date : 2014-03-10 DOI: 10.2147/BTAT.S54023

J. Prieto

License. The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on how to request permission may be found at: http://www.dovepress.com/permissions.php Botanics: Targets and Therapy 2014:4 1–9 Botanics: Targets and Therapy Dovepress

许可证。许可的完整条款可在http://creativecommons.org/licenses/by-nc/3.0/上获得。允许非商业用途的工作，没有任何进一步的许可，从多芬医学出版社有限公司，只要工作适当署名。超出许可范围的许可由多芬医疗新闻有限公司管理。有关如何请求许可的信息可在以下网站找到:http://www.dovepress.com/permissions.php Botanics: Targets and Therapy 2014:4 1-9 Botanics: Targets and Therapy Dovepress

引用次数: 18

Phytothermotherapy in osteoarthritis: new evidence for an old therapy 植物热疗法治疗骨关节炎:旧疗法的新证据

Botanics : targets and therapy

Pub Date : 2013-11-14 DOI: 10.2147/BTAT.S44217

S. Cheleschi, S. Tenti, M. Galeazzi, A. Fioravanti

License. The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on how to request permission may be found at: http://www.dovepress.com/permissions.php Botanics: Targets and Therapy 2013:3 57–63 Botanics: Targets and Therapy Dovepress

许可证。许可的完整条款可在http://creativecommons.org/licenses/by-nc/3.0/上获得。允许非商业用途的工作，没有任何进一步的许可，从多芬医学出版社有限公司，只要工作适当署名。超出许可范围的许可由多芬医疗新闻有限公司管理。有关如何申请许可的信息可在以下网址找到:http://www.dovepress.com/permissions.php Botanics: Targets and Therapy 2013:3 57-63 Botanics: Targets and Therapy Dovepress

引用次数: 0