Integrative medicine international最新文献

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The Effect of Riding as an Alternative Treatment for Children with Cerebral Palsy: A Systematic Review and Meta-Analysis 骑行作为脑瘫儿童替代治疗的效果:系统回顾和荟萃分析

Integrative medicine international

Pub Date : 2015-04-02 DOI: 10.1159/000368408

Guoqing Wang, Ruiqin Ma, Guangwei Qiao, K. Wada, Y. Aizawa, T. Satoh

Background and Objectives: There is a substantial body of evidence assessing the effects of equine-assisted therapy on physiological and psychological aspects of individuals with disabilities. This study aimed to evaluate the physiological benefits of this alternative therapy for children with cerebral palsy (CP) by means of a systematic review and meta-analysis. Methods: This systematic review included all randomized and nonrandomized clinical trials of hippotherapy (HT), therapeutic horse riding (THR), and artificial saddle (AS) for the treatment of children with CP by a systematic search in Medline, Embase, Cochrane Library, and other databases up to November 2012. Articles were assessed for inclusion eligibility and quality by two independent reviewers. Any discordant case was re-reviewed and consensus was obtained after sufficient discussion. A random effects model of meta-analysis was applied to provide summary statistics for each outcome. Results: Seven randomized controlled trials (RCTs), 4 non-RCTs, and 7 self-controlled studies were included for quality assessment. Ten studies assessed the effect of HT, 5 evaluated THR, and 3 evaluated AS. The sample size differed from 3 to 72, and the quality ranged from low to moderate. Six studies were included in the meta-analysis, and there was a significant improvement in the 66-item Gross Motor Function Measure (GMFM-66), the GMFM-66/88 total score, and the dimension E of the GMFM. Although the asymmetry score tended to be reduced, it failed to reach statistical significance. Conclusions: HT, THR, and AS seem to improve the total score of the gross motor function via improvement of the walking, running, and jumping dimension. However, they are not likely to be of benefit to the symmetry of postural muscle activity. Studies included in this review lack high-quality RCTs with a sufficient number of subjects, which thus warrants further evaluations of these modalities using large-scale well-designed RCTs.

背景和目的:有大量的证据评估马辅助治疗对残疾人生理和心理方面的影响。本研究旨在通过系统回顾和荟萃分析来评估这种替代疗法对脑瘫儿童(CP)的生理益处。方法:本系统综述通过系统检索Medline、Embase、Cochrane Library等数据库，纳入截至2012年11月的所有海马疗法(HT)、治疗性骑马(THR)和人工马鞍(AS)治疗小儿CP的随机和非随机临床试验。两名独立审稿人对文章的纳入资格和质量进行评估。任何不一致的情况重新审查，并在充分讨论后达成共识。采用随机效应模型进行meta分析，对每个结果进行汇总统计。结果:纳入7项随机对照试验(rct)、4项非随机对照试验和7项自我对照研究进行质量评价。10项研究评估HT的效果，5项研究评估THR, 3项研究评估AS。样本量从3到72不等，质量从低到中等。meta分析共纳入6项研究，在66项粗大运动功能量表(GMFM-66)、GMFM-66/88总分、GMFM维度E均有显著改善。不对称评分虽有降低的趋势，但未达到统计学意义。结论:HT、THR和AS似乎通过改善步行、跑步和跳跃维度来改善大运动功能总分。然而，它们不太可能对姿势肌肉活动的对称性有益。本综述中纳入的研究缺乏足够数量的高质量随机对照试验，因此需要使用设计良好的大规模随机对照试验对这些模式进行进一步评估。

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引用次数: 6

Front & Back Matter 正面和背面

Integrative medicine international

Pub Date : 2015-04-01 DOI: 10.1159/000382037

Tao Yang, Xiyuan Zheng, Hua Zhuo, F. Xing, K. Ohashi, Yoshiharu Yamamoto, Martin H. Teicher, Min Li, K. Chua, Jing-jing Li, L. Drucaroff, Agustín J. Ramírez, Ramiro A. Sánchez, D. Cardinali, S. Pérez-Lloret, Cheng-hai Liu, Hua Zhou, Wenfei Jiang, Weidong Pan, M. Avijgan, M. Avijgan, M. Najafi, Najmeh Salek, Azin Momeni, S. Shabani, Fahimeh Salehi, Jingui Xue, F. Zhao, Yuqi Wang, Jialin Gu, Xiaolong Wang, Junjie Gao, Druckerei Stückle

引用次数: 0

Locomotor micro-activities associated with therapeutic responses in patients with seasonal affective disorders. 季节性情感障碍患者的运动微活动与治疗反应相关。

Integrative medicine international

Pub Date : 2015-04-01 Epub Date: 2015-02-11 DOI: 10.1159/000371352

Kyoko Ohashi, Yoshiharu Yamamoto, Martin H Teicher

Background: Psychomotor retardation, leaden paralysis and fatigue are often used to describe patients with depressive disorders. However, there is limited understanding of their meaning and how they are objectively manifested in the physical world. Patients with seasonal affective disorder (SAD) are characteristically hypoactive, and experience restoration in energy during effective treatment with bright light. In this study, we attempt to identify quantitative metrics of psychomotor activity that correspond to the clinical perceptions of hypoactivity and to the early activating effects of treatment.

Methods: Novel means of assessing the microstructure of activity was employed using wavelets and Hurst exponents to indicate the proclivity of subjects to persist at higher and lower levels of activity. This was assesed using actigraphs in 16 unmedicated patients with SAD before and following two weeks of bright light therapy.

Results: Two weeks of phototherapy had no significant effect on mean levels of diurnal activity, but altered the microstructure of the activity. Specifically, phototherapy produced a significant reduction in inertial resistance in patients who had a 50% or greater reduction in Hamilton Depression scores (n=8), as reflected in reduced tendency to persist at low levels of activity. There was also a strong correlation between ratings of fatigue and measures of persistence at high versus low activity in initial responders, but not in initial non-responders.

Conclusion: These findings suggest that light therapy alters the nature of diurnal activity troughs in early responsive patients, reducing their tendency to persist at low levels, possibly reflecting an alleviation of psychomotor retardation.

背景:精神运动迟缓、铅性麻痹和疲劳常被用来描述抑郁症患者。然而，人们对它们的含义以及它们如何在物质世界中客观表现出来的理解有限。季节性情感障碍(SAD)患者具有典型的低活性，并且在明亮的光线有效治疗期间经历能量恢复。在这项研究中，我们试图确定精神运动活动的定量指标，这些指标与临床认知的活动不足和治疗的早期激活效应相对应。方法:采用小波和赫斯特指数的新方法来评估活动的微观结构，以表明受试者在较高和较低水平的活动中持续的倾向。在16名未接受药物治疗的SAD患者接受两周强光治疗前后，使用活动记录仪对其进行了评估。结果:两周的光疗对平均日活动水平没有显著影响，但改变了活动的微观结构。具体来说，在汉密尔顿抑郁评分降低50%或更高的患者中，光疗显著降低了惯性阻力(n=8)，这反映在持续低水平活动的倾向降低。在最初的反应者中，疲劳等级和高活动与低活动的持久性测量之间也存在很强的相关性，但在最初的无反应者中则没有。结论:这些发现表明，光疗法改变了早期反应患者的昼夜活动波谷的性质，减少了他们持续低水平的倾向，可能反映了精神运动迟缓的缓解。

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引用次数: 6

A New Method in Auricular Medicine for the Investigation of the Nogier Reflex 耳医学研究Nogier反射的新方法

Integrative medicine international

Pub Date : 2015-03-31 DOI: 10.1159/000381147

G. Litscher, F. Bahr, D. Litscher, Lequan Min, P. Rong

Background: Although there is as yet no scientific consensus on this topic, the Nogier reflex or reflex auriculo-cardiac (RAC; also vascular autonomic signal) is an important method in auricular medicine. This article introduces a new methodological approach for the detection and quantification of the RAC. Methods: A new high-resolution imaging technique for the registration of pulsatory surface changes might allow the RAC to be quantified reproducibly for the first time. The method combines an innovative microscope system (available at the Medical University of Graz), video analysis software, and special image processing software (from the Beijing University of Science and Technology). Results: Even small, pulse-dependent alterations of the skin surface could be clearly visualized. Conclusion: The pilot measurement confirmed the validity of the new methodological approach. Further investigations are necessary and in progress.

背景:虽然在这个话题上还没有科学共识，Nogier反射或耳心反射(RAC;血管自主信号是耳医学的重要方法。本文介绍了一种检测和定量RAC的新方法。方法:一种新的高分辨率成像技术，用于配准脉动表面变化，可能使RAC首次定量可重复性。该方法结合了一种创新的显微镜系统(格拉茨医科大学提供)、视频分析软件和特殊的图像处理软件(来自北京科技大学)。结果:即使是很小的、脉冲依赖性的皮肤表面变化也能清晰地显示出来。结论:初步测量证实了新方法的有效性。进一步的调查是必要的，并且正在进行中。

引用次数: 14

Clinical Value of Brainstem Auditory Evoked Potential in the Diagnosis of Vertebrobasilar Ischemia 脑干听觉诱发电位诊断椎基底动脉缺血的临床价值

Integrative medicine international

Pub Date : 2015-03-25 DOI: 10.1159/000380909

Xiao-jing Zhang, Lijun Zhang, Jing Zhu, Minyi He, Ze Wang, Jun Wang, Minjun Zhang, Fanghua Li, J. Shen, Yu Bai, Ji-Wei Cheng

Objective: The objective of this study was to explore the clinical value of brainstem auditory evoked potential (BAEP) in the diagnosis of vertebrobasilar ischemia (VBI). Methods: The subjects were divided into the 2 following groups: an observation group of 300 VBI patients and a control group of 100 normal healthy volunteers. BAEP examination was carried out in both groups, and then the results were analyzed and compared. Results: BAEP abnormalities were observed in 59% (177 out of 300) of the patients in the observation group: brainstem type 64.4% (114 cases), inner-ear type 7.4% (13 cases), and mixed type 28.2% (50 cases). In the control group, abnormalities were observed in only 9% (9 cases): inner-ear type 66.7% (6 cases) and mixed type 33.3% (3 cases). There was a statistically significant difference between the 2 groups in their total abnormality rates (p < 0.05). After the neck twisting test, the BAEP abnormality rate of the observation group rose to 85% (255 cases) and was significantly different from that of normal BAEP (p < 0.05). Conclusion: BAEP is an easy but effective auxiliary means for the noninvasive examination of VBI with a high positive rate, thus providing objective evidence for the diagnosis of VBI that may be useful in future clinical application.

目的:探讨脑干听觉诱发电位(BAEP)在椎基底动脉缺血(VBI)诊断中的临床价值。方法:将受试者分为两组:观察组300例VBI患者，对照组100例正常健康志愿者。两组均行BAEP检查，并对结果进行分析比较。结果:观察组300例患者中有177例(59%)出现BAEP异常，其中脑干型114例(64.4%)，内耳型13例(7.4%)，混合型50例(28.2%)。对照组异常仅9%(9例)，内耳型66.7%(6例)，混合型33.3%(3例)。两组总异常率比较，差异有统计学意义(p < 0.05)。观察组患者经扭颈试验后BAEP异常率为85%(255例)，与BAEP正常组差异有统计学意义(p < 0.05)。结论:BAEP是一种简便有效的无创检查VBI的辅助手段，阳性率高，为VBI的诊断提供了客观依据，对今后的临床应用有一定的参考价值。

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引用次数: 0

Identification of Visceral Patterns in Patients with Stress-Related Disorders 应激相关障碍患者内脏模式的鉴定

Integrative medicine international

Pub Date : 2015-03-19 DOI: 10.1159/000375532

T. Kondo, S. Tokunaga, H. Sugahara, K. Yoshimasu, Y. Kanemitsu, C. Kubo

Background: There is no report on traditional Chinese patterns associated with stress-related disorders such as eating disorder, pain disorder, primary insomnia, functional dyspepsia, irritable bowel syndrome, hyperventilation syndrome, bronchial asthma, and dystonia. Therefore, a large-size case-control study was conducted. Methods: A total of 914 new cases were assessed at a psychosomatic clinic of a tertiary medical care center. The severity of visceral patterns was analyzed according to the main symptoms described and a comprehensive questionnaire. Three patterns of the liver, four of the heart, and one of the kidney as well as dual deficiency of the heart and spleen were assessed. Results: Multiple logistic regression analysis revealed that liver qi depression, liver fire flaming upward, phlegm clouding the pericardium, and dual deficiency of the heart and spleen were associated with bulimia nervosa in females. Liver fire flaming upward and phlegm turbidity were associated with primary insomnia and pain disorder, respectively, in males. An excess pattern was associated with irritable bowel syndrome, while dual deficiency of the heart and spleen was associated with functional dyspepsia in females. On the other hand, the deficiency-excess pattern was reverse in males. Phlegm fire harassing the heart was associated with hyperventilation syndrome in females. Phlegm clouding the pericardium and two kinds of yin deficiency were associated with dystonia in females. Conclusion: Primary insomnia, pain disorder in males, gastrointestinal disorders, and hyperventilation syndrome are each attributed to a single individual pattern. The pattern is different between both sexes. Bulimia nervosa and dystonia are attributed to a few patterns respectively.

背景:目前还没有关于饮食失调、疼痛障碍、原发性失眠、功能性消化不良、肠易激综合征、过度通气综合征、支气管哮喘和肌张力障碍等应激相关疾病的中国传统模式的报道。因此，我们进行了大规模的病例对照研究。方法:对某三级医疗中心心身门诊914例新发病例进行评估。根据所描述的主要症状和全面的问卷调查分析内脏模式的严重程度。评估了三种肝型、四种心型、一种肾型以及心脾双虚型。结果:多元logistic回归分析显示，女性神经性贪食与肝郁、肝火上燃、痰浊心包、心脾双虚有关。肝火上旺与痰浊分别与男性原发性失眠和疼痛障碍相关。过量模式与肠易激综合征有关，而心脏和脾脏双重缺乏与女性功能性消化不良有关。另一方面，男性则相反。痰火扰心与女性换气过度综合征相关。心包痰浊和两种阴虚与女性肌张力障碍有关。结论:原发性失眠、男性疼痛障碍、胃肠道疾病和过度通气综合征均可归因于单一个体模式。这种模式在两性之间是不同的。神经性贪食症和肌张力障碍分别归因于几种模式。

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引用次数: 3

Integrative Medicine and Drug-Induced Vestibulopathy following Brucellosis Treatment: Clinical Practice 布鲁氏菌病治疗后中西医结合与药物性前庭病变:临床实践

Integrative medicine international

Pub Date : 2015-02-28 DOI: 10.1159/000371800

M. Avijgan, M. Avijgan, M. Najafi, Najmeh Salek, Azin Momeni, S. Shabani, Fahimeh Salehi

Brucellosis is still one of the most common causes of fever of unknown origin (FUO) in endemic areas and is associated with several complications. Here, we report a patient with a diagnosis of brucellosis and FUO who developed a rare complication of vestibulopathy in the course of treatment and follow-up. We treated the vestibulopathy with acupuncture, and during 10 days of treatment, the irreversible complication of vestibulopathy disappeared. To the best of our knowledge, this is the first case report of brucellosis with vestibulopathy treated with traditional medicine that achieved complete improvement within 10 days.

布鲁氏菌病仍然是流行地区不明原因发热的最常见原因之一，并与几种并发症有关。在此，我们报告一位诊断为布鲁氏菌病和FUO的患者，在治疗和随访过程中出现了罕见的前庭病变并发症。我们用针刺治疗前庭病变，经过10天的治疗，前庭病变的不可逆并发症消失。据我们所知，这是第一例用传统药物治疗布鲁氏菌病前庭病变并在10天内完全改善的病例报告。

引用次数: 1

Constitutional Study of Parkinson's Disease Patients Based on Traditional Chinese Medicine Pattern Differentiation 基于中医辨证的帕金森病患者体质研究

Integrative medicine international

Pub Date : 2015-02-20 DOI: 10.1159/000369530

Jing-jing Li, K. Chua, Min Li

Objectives: It was the aim of this study to determine whether (1) Parkinson's disease (PD) patients can be divided into different traditional Chinese medicine (TCM) constitutions based on the 44-item Traditional Chinese Medical Constitutional Scale and Classification (TCM-CSC, Chinese version, 中醫體質及分型量表), (2) whether levodopa usage correlates with the TCM classification type, and (3) whether there is a difference in the mean daily intake of levodopa between males and females in any of the constitutional types. Methods: PD patients who had visited the TCM clinic of the Hong Kong Baptist University (HKBU) or who had attended the PD public talks organized by HKBU and the Association of Parkinson's Disease in Hong Kong were invited for interviews with TCM assessors. The TCM-CSC (Chinese version) was used in the assessment to divide patients into four different constitutions: the balanced constitution (type A), the yang-deficiency constitution (type B), the yin-deficiency constitution (type C) and the stasis constitution (type D). Results: Sixty-three patients (29 males, 34 females; mean age 63.65 ± 8.116 years; mean PD duration 5.49 ± 4.544 years) participated in the study. Sixteen PD patients (26%) had only one type of TCM constitution, while 47 PD patients (74%) had more than one type of TCM constitution. Type D patients showed the lowest intake of daily levodopa. There was no significant difference in the mean daily intake of levodopa between males and females in any of the constitutional types. Conclusions: (1) PD patients cannot be divided into different constitutional types based on the TCM-CSC effectively. (2) In general, levodopa usage does not correlate with the constitutional type; however, patients with the stasis constitution (type D) showed the lowest levodopa intake compared to the other constitutions. (3) There was no significant difference in the mean daily intake of levodopa between males and females. Further research on the treatment pattern of different TCM constitutions, using large samples, is warranted.

目的:本研究的目的是确定(1)基于44项中医体质量表和分类(TCM- csc，中文版)是否可以将帕金森病(PD)患者划分为不同的中医体质;(2)左旋多巴的使用是否与中医分类类型相关;(3)在任何体质类型中，男性和女性左旋多巴的平均每日摄入量是否存在差异。方法:邀请到香港浸会大学中医诊所就诊或参加浸会大学与香港帕金森病协会举办的帕金森病公开讲座的帕金森病患者与中医评估员进行访谈。采用中医体质分析(中文版)将患者分为平衡型(A型)、阳虚型(B型)、阴虚型(C型)、瘀型(D型)四种不同体质。结果:63例患者(男29例，女34例;平均年龄63.65±8.116岁;平均PD病程(5.49±4.544年)参加研究。16例(26%)PD患者仅有一种中医体质，47例(74%)PD患者有一种以上中医体质。D型患者左旋多巴日摄入量最低。在任何体质类型中，男性和女性左旋多巴的平均每日摄入量没有显著差异。结论:(1)不能根据中医体质分类有效划分PD患者的不同体质类型。(2)一般情况下，左旋多巴的使用与体质类型无关;然而，与其他体质相比，瘀型(D型)患者左旋多巴摄入量最低。(3)男性和女性左旋多巴的平均日摄入量无显著差异。进一步研究不同中医体质的治疗模式，使用大样本，是必要的。

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引用次数: 3

Integrative Cardiac Reserve 综合心脏储备

Integrative medicine international

Pub Date : 2015-02-13 DOI: 10.1159/000369808

Jingui Xue, F. Zhao, Yuqi Wang, Jialin Gu, Junjie Gao, Xiaolong Wang, Hua Zhou

Recent progress suggests that integrative cardiac reserve is important in coronary artery disease, chronic heart failure, cardiomyopathy, and other cardiovascular diseases. Integrative cardiac reserve includes coronary flow reserve, myocardial reserve, energy reserve, and heart rate reserve. In the case of stress reaction, coronary flow reserve can provide excessive blood and energy supply and increase the heart rate. Thus, the dysfunctional myocardium can recover its contractile characteristics. In this study, we review the current knowledge on integrative cardiac reserve in order to provide an additional cure and strategy for the treatment of heart diseases.

最近的进展表明，综合心脏储备在冠状动脉疾病、慢性心力衰竭、心肌病和其他心血管疾病中很重要。综合心脏储备包括冠状动脉血流储备、心肌储备、能量储备和心率储备。在应激反应的情况下，冠状动脉血流储备可以提供过多的血液和能量供应，增加心率。因此，功能失调的心肌可以恢复其收缩特性。在本研究中，我们回顾了目前关于综合心脏储备的知识，以便为心脏病的治疗提供额外的治疗方法和策略。

引用次数: 2

Integrative Cognitive Reserve 综合认知储备

Integrative medicine international

Pub Date : 2015-01-30 DOI: 10.1159/000371467

Wenfei Jiang, Weidong Pan

The cognitive reserve (CR) against cognitive damage stems from a series of observations. The purpose of this study is to perform a systematic review to summarize the concept of CR. A variety of factors such as age, education level, reading ability, and vocabulary have an impact on the reserve according to a large amount of research and may influence CR. Furthermore, due to measurement difficulties, efforts to explore CR have been hindered. This is why different methods have been used to quantify reserve, such as multiple indicators multiple causes, residual variance in episodic memory performance, the Sole-Padulles Childhood Enrichment measure, the Mini-Mental State Examination, the Peabody Picture Vocabulary Test, the Hollingshead Two-Factor Index of Social Position, the Cattell Culture Fair Intelligence Test, and the Digit Span Subtests of the Wechsler Memory Scale. In addition, numerous studies explored the role of CR in various diseases, such as multiple sclerosis, hepatitis C, obesity, and sleep onset/maintenance difficulties. CR plays a significant role in the morbidity of these diseases, and since integrative medicine may be able to modify CR, it might be an effective tool to prevent these serious diseases.

针对认知损伤的认知储备(cognitive reserve, CR)源于一系列的观察。本研究的目的是对CR的概念进行系统综述，大量研究表明，年龄、受教育程度、阅读能力、词汇量等多种因素都会对CR产生影响，并可能对CR产生影响，而且由于测量困难，阻碍了对CR的探索。这就是为什么人们使用了不同的方法来量化储备，如多指标多原因、情景记忆表现的剩余方差、单-双叶儿童期丰富度测量、迷你精神状态测试、皮博迪图片词汇测试、霍林斯黑德社会地位双因素指数、卡特尔文化公平智力测试和韦氏记忆量表的数字广度子测试。此外，许多研究探讨了CR在多种疾病中的作用，如多发性硬化症、丙型肝炎、肥胖和睡眠开始/维持困难。CR在这些疾病的发病率中起着重要作用，由于中西医结合可能能够改变CR，因此它可能是预防这些严重疾病的有效工具。

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引用次数: 1

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