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Abnormal Brain State in Major Depressive Disorder: A Resting-State Magnetic Resonance Study.
IF 2.4 3区 医学 Q3 NEUROSCIENCES Pub Date : 2025-02-03 DOI: 10.1089/brain.2024.0062
Siyu Fan, Rui Qian, Nanxue Duan, Hongping Wang, Yue Yu, Yang Ji, Xiaohui Xie, Yue Wu, Yanghua Tian

Background: Respective changes in resting-state linear and nonlinear measures in major depressive disorder (MDD) have been reported. However, few studies have used integrated measures of linear and nonlinear brain dynamics to explore the pathological mechanisms underlying MDD. Method: Forty-two patients with MDD and 42 sex- and age-matched healthy controls (HC) underwent resting-state functional magnetic resonance imaging to calculate multiscale entropy (MSE) and regional homogeneity (ReHo). The MSE-ReHo coupling of the whole gray matter and the MSE/ReHo ratio (the complexity of intensity homogeneity per unit time series) of each voxel were compared between the two groups. To evaluate the discriminative capacity of ratio features between patients with MDD and HC, we employed the support vector machine (SVM) learning method. Results: We observed that patients with MDD displayed increased MSE/ReHo ratio mainly in the orbitofrontal cortex, sensorimotor areas, and visual cortex. Moreover, significant correlations were observed between MSE/ReHo ratio and clinical indicators, including depression severity and cognitive function tests. The SVM model demonstrated high accuracy in differentiating patients with MDD from HC, highlighting the potential of the MSE/ReHo ratio as a diagnostic and prognostic tool. Conclusions: The aberrant MSE/ReHo ratio implicated the underlying mechanisms of depressive symptoms and cognitive impairment in patients with MDD. It may represent a critical state of the brain region, reflecting the degree of chaos and order in the brain region. Integrating linear and nonlinear combinations of brain signals holds promise for diagnosing psychiatric disorders.

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引用次数: 0
Developmental Mismatch Across Brain Modalities in Young Children. 幼儿脑发育模式的不匹配。
IF 2.4 3区 医学 Q3 NEUROSCIENCES Pub Date : 2024-12-20 DOI: 10.1089/brain.2024.0046
Xiangyu Long, Madison Long, Jamie Roeske, Jess E Reynolds, Catherine Lebel

Background: Brain development during the preschool period is complex and extensive and underlies ongoing behavioral and cognitive maturation. Increasing understanding of typical brain maturation during this time is critical to early identification of atypical development and could inform treatments and interventions. Previous studies have suggested mismatches between brain structural and functional development in later childhood and adolescence. The current study aimed to delineate the developmental matches and mismatches between brain measures from multiple magnetic resonance imaging modalities in young children. Methods: Brain volume, cortical thickness, fractional anisotropy, cerebral blood flow (CBF), amplitude of low-frequency fluctuations (ALFF), regional homogeneity (ReHo), and eigenvector centrality mapping (ECM) were included. Multi-modal neuroimages for 159 datasets from 67 typically developing preschoolers (2.0-7.6 years old) were collected and analyzed. Results: Functional measures (CBF, ECM, ReHo, ALFF) had similar developmental trajectories across regions, whereas development trajectories for brain volumes and cortical thickness were more heterogeneous. Furthermore, within individuals, brain volumes and cortical thickness were very good at predicting individual scans from prior longitudinal scans. Conclusions: These findings provide a more detailed characterization of the complex interplay of different types of brain development in the early years, laying the foundation for future studies on the impact of environmental factors and neurodevelopmental disorders on the development matches/mismatches patterns between brain areas and modalities.

背景:学前时期的大脑发育是复杂而广泛的,是持续的行为和认知成熟的基础。在此期间增加对典型大脑成熟的了解对于早期识别非典型发育至关重要,并且可以为治疗和干预提供信息。先前的研究表明,在儿童后期和青少年时期,大脑结构和功能发育不匹配。目前的研究旨在描述幼儿多种磁共振成像方式的大脑测量之间的发育匹配和不匹配。方法:包括脑容量、皮质厚度、分数各向异性、脑血流量(CBF)、低频波动幅度(ALFF)、区域均匀性(ReHo)和特征向量中心性映射(ECM)。对67名典型发育学龄前儿童(2.0 ~ 7.6岁)159个数据集的多模态神经图像进行了收集和分析。结果:功能测量(CBF, ECM, ReHo, ALFF)在不同区域具有相似的发展轨迹,而脑体积和皮层厚度的发展轨迹则更为异质性。此外,在个体中,脑容量和皮质厚度可以很好地预测先前纵向扫描的个体扫描。结论:这些发现为早期不同类型大脑发育的复杂相互作用提供了更详细的表征,为未来研究环境因素和神经发育障碍对脑区和模式之间发育匹配/不匹配模式的影响奠定了基础。
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引用次数: 0
Distinct Neural Connectivity Patterns During Music Listening and Imagination: An Electroencephalography Study. 不同的神经连接模式在音乐听和想象:脑电图研究。
IF 2.4 3区 医学 Q3 NEUROSCIENCES Pub Date : 2024-12-10 DOI: 10.1089/brain.2024.0042
Kiarash Fouladi, Hessam Ahmadi, Ali Motie-Nasrabadi

Background: The brain's function changes during various activities, and numerous studies have explored this field. An intriguing and significant area of research is the brain's functioning during imagination and periods of inactivity. Objective: This study explores the differences in brain connectivity during music listening and imagination: by identifying distinct neural connectivity patterns and providing insights into the cognitive mechanisms underlying auditory imagination. Methods: Effective connectivity matrices were generated using generalized partial directed coherence (GPDC) and directed Directed Transfer Function (dDTF) methods applied to non-invasive electroencephalography data from these two conditions. Statistical tests were performed to illustrate the differences in brain connectivity, followed by the creation of brain graphs and the application of a non-parametric permutation test to demonstrate statistical significance. Data classification between listening to music and imagining it was performed using an Support Vector Machine (SVM) classifier with different feature vectors. Results: Combining features extracted from GPDC and dDTF achieved an accuracy of 71.3% while using GPDC and dDTF features individually yielded accuracies of 60% and 62.1%, respectively. Among all the graph's global features, only modularity and small-worldness showed statistically significant differences in dDTF and GPDC. Overall, findings reveal that information flows from the left hemisphere to the right hemisphere increases during music imagination compared with listening, highlighting distinct neural connectivity patterns associated with imaginative processes. Conclusion: The study provides novel insights into the distinct neural connectivity patterns during music listening and imagination, contributing to the broader understanding of cognitive processes associated with auditory imagination and perception.

背景:大脑的功能在各种活动中发生变化,许多研究都在探索这一领域。一个有趣而重要的研究领域是大脑在想象和不活动期间的功能。目的:通过识别不同的神经连接模式,探讨音乐聆听和想象过程中大脑连接的差异,并为听觉想象的认知机制提供见解。方法:利用广义部分定向相干性(GPDC)和定向定向传递函数(dDTF)方法对这两种情况下的无创脑电图数据生成有效的连通性矩阵。通过统计测试来说明大脑连通性的差异,随后创建脑图并应用非参数排列测试来证明统计显著性。利用不同特征向量的支持向量机分类器对听音乐和想象音乐进行数据分类。结果:结合GPDC和dDTF特征提取的准确率为71.3%,单独使用GPDC和dDTF特征提取的准确率分别为60%和62.1%。在图的全局特征中,只有模块化和小世界性在dDTF和GPDC上表现出统计学上的显著差异。总的来说,研究结果表明,与听音乐相比,在音乐想象过程中,从左半球到右半球的信息流增加,突出了与想象过程相关的独特神经连接模式。结论:本研究对音乐聆听和想象过程中不同的神经连接模式提供了新的见解,有助于更广泛地理解与听觉想象和感知相关的认知过程。
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引用次数: 0
The Effect of Modular Degeneracy on Neuroimaging Data. 模变性对神经影像学数据的影响。
IF 2.4 3区 医学 Q3 NEUROSCIENCES Pub Date : 2024-12-10 DOI: 10.1089/brain.2023.0090
Elisabeth C Caparelli, Hong Gu, Yihong Yang

Introduction: The concept of community structure, based on modularity, is widely used to address many systems-level queries. However, its algorithm, based on the maximization of the modularity index Q, suffers from degeneracy problem, which yields a set of different possible solutions. Methods: In this work, we explored the degeneracy effect of modularity principle on resting-state functional magnetic resonance imaging (rsfMRI) data, when it is used to parcellate the cingulate cortex using data from the Human Connectome Project. We proposed a new iterative approach to address this limitation. Results: Our results show that current modularity approaches furnish a variety of different solutions, when these algorithms are repeated, leading to different number of subdivisions for the cingulate cortex. Our new proposed method, however, overcomes this limitation and generates more stable solution for the final partition. Conclusion: With this new method, we were able to mitigate the degeneracy problem and offer a tool to use modularity in a more reliable manner, when applying it to rsfMRI data.

简介:基于模块化的社区结构概念被广泛用于处理许多系统级查询。然而,其算法基于模块化指标Q的最大化,存在退化问题,产生一组不同的可能解。方法:在这项工作中,我们探索了模块化原理对静息状态功能磁共振成像(rsfMRI)数据的简并效应,当它被用来利用人类连接组计划的数据打包扣带皮层时。我们提出了一种新的迭代方法来解决这一限制。结果:我们的研究结果表明,当前的模块化方法提供了各种不同的解决方案,当这些算法被重复时,导致不同数量的扣带皮层细分。然而,我们提出的新方法克服了这一限制,并为最终分区生成了更稳定的解。结论:通过这种新方法,我们能够减轻退化问题,并提供一种工具,以更可靠的方式使用模块化,当应用于rsfMRI数据时。
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引用次数: 0
Specific Associations in the Alpha Frequency Between the Subcomponents of Rumination and the Subsystems of the Default Mode Network Among Bipolar I Disorder Patients. 双相情感障碍 I 患者的反刍子成分与默认模式网络子系统之间阿尔法频率的特定关联。
IF 2.4 3区 医学 Q3 NEUROSCIENCES Pub Date : 2024-12-01 Epub Date: 2024-10-24 DOI: 10.1089/brain.2023.0086
Hao Tang, Jiabo Shi, Siqi Zhang, Yu Chen, Tingting Xiong, Xumiao Wang, Zhilu Chen, Zhongpeng Dai, Zhijian Yao, Qing Lu

Introduction: Rumination in bipolar disorder (BD) is well documented. Recent neuroimaging studies highlight the role of the default mode network (DMN) in rumination, while few studies have evaluated the DMN activity in BD rumination, particularly the underlying neuroelectrophysiology. Methods: A total of 44 patients with depressed bipolar I disorder (BD-I) and 46 healthy controls underwent resting-state magnetoencephalography. Two core hubs of the DMN, the posterior cingulate cortex (PCC), and anterior medial prefrontal cortex, together with the dorsal medial prefrontal cortex (dmPFC) and the medial temporal lobe (MTL) subsystems, were identified as the regions of interest. The power envelope method was used to determine the alpha band's cross-subsystem functional connectivity (FC). After comparing the rumination and DMN FC between the groups, Spearman partial correlation analysis was performed to evaluate the relationship between aberrant FC and rumination in BD-I patients. Results: BD-I patients demonstrated more global rumination, including higher subcomponent scores of brooding and reflection. In addition, the alpha frequency FC of the PCC-dmPFC and dmPFC-MTL subsystems within the DMN was dramatically increased in the BD-I group. The former was strongly associated with reflection, whereas the latter was related to brooding. Conclusion: The findings suggest that the reflection and brooding components of rumination are selectively related to the alpha frequency FC of the PCC-dmPFC and dmPFC-MTL subsystems, respectively. These associations highlight the significance of DMN activities in rumination among BD-I patients and have implications for future rumination interventions.

导言:双相情感障碍(BD)患者的反刍已被充分记录。最近的神经影像学研究强调了默认模式网络(DMN)在反刍中的作用,但很少有研究评估了双相情感障碍反刍中的DMN活动,尤其是其潜在的神经电生理。研究方法44名双相情感障碍抑郁症(BD-I)患者和46名健康对照者接受了静息态脑磁图检查。DMN的两个核心枢纽--后扣带回皮层(PCC)和前内侧前额叶皮层--以及背内侧前额叶皮层(dmPFC)和内侧颞叶(MTL)子系统被确定为研究区域。功率包络法用于确定α波段的跨子系统功能连接(FC)。在比较了各组间的反刍和 DMN FC 后,进行了斯皮尔曼偏相关分析,以评估 BD-I 患者的异常 FC 与反刍之间的关系。结果显示BD-Ⅰ患者表现出更多的全局性反刍,包括更高的沉思和反省子成分得分。此外,在BD-Ⅰ组中,DMN内PCC-dmPFC和dmPFC-MTL子系统的α频率FC显著增加。前者与反思密切相关,而后者则与忧郁有关。结论研究结果表明,反刍中的反思和沉思部分分别与 PCC-dmPFC 和 dmPFC-MTL 子系统的阿尔法频率 FC 选择性相关。这些关联凸显了DMN活动在BD-I患者反刍中的重要性,并对未来的反刍干预产生了影响。
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引用次数: 0
Advancing Precision Therapies in Brain Connectivity. 推进大脑连接的精确治疗。
IF 2.4 3区 医学 Q3 NEUROSCIENCES Pub Date : 2024-12-01 DOI: 10.1089/brain.2024.0090
Francisco Gómez, Jitka Annen, Steven Laureys
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引用次数: 0
Repetitive Transcranial Magnetic Stimulation on Individualized Spots Based on Task functional Magnetic Resonance Imaging Improves Swallowing Function in Poststroke Dysphagia. 基于任务 fMRI 的重复经颅磁刺激个体化点可改善中风后吞咽困难患者的吞咽功能。
IF 2.4 3区 医学 Q3 NEUROSCIENCES Pub Date : 2024-12-01 Epub Date: 2024-11-04 DOI: 10.1089/brain.2024.0021
Meiyuan Chen, Ziyang Huang, Yi Chen, Xiaochuan Wang, Xiaojun Ye, Wenjie Wu

Background: Functional magnetic resonance imaging (fMRI) has not previously been used to localize the swallowing functional area in repetitive transcranial magnetic stimulation (rTMS) treatment for poststroke dysphagia; Traditionally, the target area for rTMS is the hotspot, which is defined as the specific region of the brain identified as the optimal location for transcranial magnetic stimulation (TMS). This study aims to compare the network differences between the TMS hotspot and the saliva swallowing fMRI activation to determine the better rTMS treatment site and investigate changes in functional connectivity related to poststroke dysphagia using resting-state fMRI. Methods: Using an information-based approach, we conducted a single case study to explore neural functional connectivity in a patient with poststroke dysphagia before, immediately after rTMS, and 4 weeks after rTMS intervention. A total of 20 healthy participants underwent fMRI and TMS hotspot localization as a control group. Neural network alterations were assessed, and functional connections related to poststroke dysphagia were examined using resting-state fMRI. Results: Compared to the TMS-induced hotspots, the fMRI activation peaks were located significantly more posteriorly and exhibited stronger functional connectivity with bilateral postcentral gyri. Following rTMS treatment, this patient developed functional connection between the brainstem and the bilateral insula, caudate, anterior cingulate cortex, and cerebellum. Conclusion: The saliva swallowing fMRI activation peaks show more intense functional connectivity with bilateral postcentral gyri compared to the TMS hotspots. Activation peak-guided rTMS treatment improves swallowing function in poststroke dysphagia. This study proposes a novel and potentially more efficacious therapeutic target for rTMS, expanding its therapeutic options for treating poststroke dysphagia.

背景:功能磁共振成像(fMRI此前,功能磁共振成像(fMRI)尚未用于定位重复经颅磁刺激(rTMS)治疗中风后吞咽困难的吞咽功能区;传统上,rTMS的目标区域是热点,即被确定为经颅磁刺激(TMS)最佳位置的大脑特定区域。本研究旨在比较经颅磁刺激热点与唾液吞咽 fMRI 激活之间的网络差异,以确定更好的经颅磁刺激治疗部位,并利用静息态 fMRI 研究与卒中后吞咽困难相关的功能连接变化:采用基于信息的方法,我们进行了一项单一病例研究,探讨了一名卒中后吞咽困难患者在经颅磁刺激治疗前、治疗后和经颅磁刺激干预四周后的神经功能连接。作为对照组,20 名健康参与者接受了 fMRI 和 TMS 热点定位。评估了神经网络的改变,并使用静息态fMRI检查了与卒中后吞咽困难相关的功能连接:结果:与TMS诱导的热点相比,fMRI激活峰的位置明显更靠后,并与双侧中央后回表现出更强的功能连接。经颅磁刺激治疗后,该患者的脑干与双侧岛叶、尾状核、前扣带回皮层和小脑之间建立了功能连接:结论:与 TMS 热点相比,唾液吞咽 fMRI 激活峰与双侧后中央回之间的功能连接更为紧密。激活峰引导的经颅磁刺激治疗可改善卒中后吞咽困难患者的吞咽功能。这项研究为经颅磁刺激提出了一个新的、潜在的更有效的治疗靶点,扩大了治疗中风后吞咽困难的治疗范围。
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引用次数: 0
Altered Functional Coupling of the Bed Nucleus of the Stria Terminalis and Amygdala in Spider Phobic Fear. 蜘蛛恐惧症中纹状体末端床核和杏仁核功能耦合的改变
IF 2.4 3区 医学 Q3 NEUROSCIENCES Pub Date : 2024-12-01 Epub Date: 2024-10-07 DOI: 10.1089/brain.2024.0031
Elisabeth Jehli, Niklaus Denier, Andrea Federspiel, Thomas Dierks, Werner Strik, Leila M Soravia, Matthias Grieder

Background: Individuals with spider phobic (SP) fear show hypervigilance and amygdala hyperactivity toward fear-associated stimuli, which may promote the development of other anxiety disorders. The amygdala is a key region within the fear network, which is connected to the anxiety system, where the bed nucleus of the stria terminalis (BNST) plays a crucial role. However, the BNST's involvement in phobic fear is unknown. Therefore, this study investigated the association of phobic fear and anxiety on these regions' functional connectivity (FC) in SP compared to healthy controls (HC). Methods: 7T-functional MRI resting-state FC of 30 individuals with SP and 45 HC was assessed to detect network differences between these groups. The association of phobic fear severity, trait anxiety, and social anxiety on FC was explored using linear regressions combined with seed-to-voxel analyses with amygdala and BNST as primary seeds, corrected for age and sex. Results: In SP, phobic fear was associated with reduced FC between the left amygdala and the right supramarginal gyrus. In contrast, anxiety severity was related to increased FC between the right BNST and the left inferior frontal gyrus. Moreover, social anxiety was related to decreased FC between bilateral BNST and left precuneus. Conclusions: These findings show changes in FC in SP, connecting fear with altered activity in the BNST and amygdala. The results suggest that persistent anxiety in phobic fear is associated with abnormal brain function in these regions, potentially explaining susceptibility to anxiety disorders and processes involved in phobic fear, such as threat perception, avoidance, and salience.

背景: 蜘蛛恐惧症(SP)患者对与恐惧相关的刺激表现出过度警觉和杏仁核过度活跃,这可能会促进其他焦虑症的发展。杏仁核是恐惧网络中的一个关键区域,它与焦虑系统相连,其中纹状体末端床核(BNST)起着至关重要的作用。然而,纹状体末端床核(BNST)在恐惧症恐惧中的参与程度尚不清楚。因此,本研究调查了与健康对照组(HC)相比,恐惧症恐惧和焦虑与这些区域功能连接(FC)的关联。方法:对30名SP患者和45名HC患者的7T-fMRI静息态FC进行评估,以检测这些群体之间的网络差异。采用线性回归结合种子到象素分析,以杏仁核和 BNST 为主要种子,并对年龄和性别进行校正,探讨了恐惧症恐惧严重程度、特质焦虑和社交焦虑与 FC 的关联。结果在 SP 中,恐惧症恐惧与左侧杏仁核和右侧边际上回之间的 FC 减少有关。相反,焦虑严重程度与右侧 BNST 和左侧额叶下回之间的 FC 增加有关。此外,社交焦虑与双侧 BNST 和左侧楔前回之间的 FC 值降低有关。结论这些研究结果表明,SP 的 FC 发生了变化,将恐惧与 BNST 和杏仁核活动的改变联系在了一起。这些结果表明,恐惧性焦虑的持续存在与这些区域的大脑功能异常有关,可能解释了焦虑症的易感性以及恐惧性恐惧的过程,如威胁感知、回避和显著性。
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引用次数: 0
Connectivity Changes Following Episodic Future Thinking in Alcohol Use Disorder. 酒精使用障碍患者发作性未来思维后的连接性变化
IF 2.4 3区 医学 Q3 NEUROSCIENCES Pub Date : 2024-12-01 Epub Date: 2024-11-04 DOI: 10.1089/brain.2024.0025
Jeremy Myslowski, Samuel M McClure, Jonathan Lisinski, Devin C Tomlinson, Anita S Kablinger, James MacKillop, Mikhail N Koffarnus, Rafaela M Fontes, Warren K Bickel, Stephen M LaConte

Introduction: Recent addiction and obesity-related research suggests that episodic future thinking (EFT) can serve as a promising intervention to promote healthy decision-making. We used data from a pilot study to investigate the acute neural effects of EFT in alcohol use disorder (AUD). Because of the limitations of those data, we additionally used data from a previously published functional MRI (fMRI) study in which participants had not received any intervention for their AUD. Methods: In an out-of-scanner, guided interview, participants (n = 24; median age = 37.3 years; median AUDIT = 22.5) generated scenarios and cues about their future (EFT intervention, n = 15) or recent past (control episodic thinking [CET] control intervention, n = 9). Then, they performed both resting-state and task-based (delay discounting [DD]) fMRI. We used nodes from the default mode network and salience networks as well as the hippocampus to perform seed-based analyses of the resting-state data. The results then guided psychophysiological interaction analyses in the DD task. In addition, we used data from a larger, previously reported study as a "no intervention" group of AUD participants (n = 50; median age = 43.3; median Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) alcohol dependence score = 7) to reproduce and aid in interpreting our key findings. Results: EFT, but not CET, participants showed statistically improved DD rates-a behavioral marker for addiction. Resting-state analyses of the left hippocampus revealed connectivity differences in the frontal poles. The directionality of this difference suggested that EFT may reduce a hypo-connectivity relationship between these regions in AUD. We also found resting-state connectivity differences between the salience network and the right dorsolateral prefrontal cortex (R DLPFC), which then led us to discover R-to-L DLPFC psychophysiological interaction differences during DD. Moreover, the resting-state salience-to-DLPFC functional connectivity showed an inverse relationship to DD rate while hyperconnectivity between left and right DLPFC reflected slower reaction times during DD trials. Discussion: These findings suggest that previously noted benefits of EFT such as the improved DD replicated here might coincide with changes in neural connectivity patterns in AUD. The alterations in connectivity highlight potential mechanisms underlying the effectiveness of EFT in improving decision-making in AUD. Understanding these neural effects may contribute to the further development of targeted interventions for AUD and related disorders.

[请注意,为了回应审稿人的要求,我们的字数超过了 300 字的限制。以下内容与第一次提交的稿件相比未作修改,审稿人要求的改动请参见实际修改后的稿件文件].引言:最近与成瘾和肥胖相关的研究表明,外显未来思维(EFT)可以作为一种有前途的干预措施,促进健康的决策制定。本研究调查了EFT对酒精使用障碍(AUD)的神经影响:方法:参与者接受简短的 EFT 或对照干预,以检查静息态连接的差异。然后,我们利用这些发现来描述延迟折现(DD)fMRI任务中的心理生理交互作用(PPI)差异。此外,我们还使用了由未接受任何干预的 AUD 参与者组成的第二个对照组,以重现并帮助解释我们的主要发现:结果:EFT参与者(而非对照组)的贴现率在统计学上有所提高,这是成瘾的行为标记。对左侧海马体的静息状态分析表明,额叶两极存在连接差异。这种差异的方向性表明,EFT 减少了 AUD 这些区域之间的低连接关系。我们还发现了显著性网络与右侧背外侧前额叶皮层(R DLPFC)之间的静息态连接差异,进而发现了 DD 期间 R 到 L DLPFC 的 PPI 差异。此外,静息状态下的显著性-DLPFC功能连通性与折扣率呈反比关系,而左右DLPFC之间的超连通性反映了在困难的DD试验中反应时间较慢:这些研究结果表明,EFT对AUD患者的神经连接模式产生了有益的改变。连通性的改变凸显了 EFT 有效改善 AUD 决策的潜在机制。了解这些神经效应可能有助于进一步开发针对 AUD 和相关障碍的干预措施。
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引用次数: 0
Frontal Cortex Acts as Causality Transition Hub from Mirror Network to Mentalizing Network During Action Intention Understanding. 额叶皮层在行动意图理解过程中充当从镜像网络到心智网络的因果关系转换枢纽
IF 2.4 3区 医学 Q3 NEUROSCIENCES Pub Date : 2024-11-27 DOI: 10.1089/brain.2024.0032
Li Zhang, Lei Zhang, Jing Wang, Yanmei Zhu

Introduction: While understanding other's action intention, mirror and mentalizing systems of human brain are successively activated in action perception and intention inference processes. Methods: To reveal the relationship between mirror and mentalizing systems during the two stages, this electroencephalogram study adopted the method of time-varying orthogonalized partial directed coherence (OPDC) to assess causal interaction between mirror and mentalizing networks during a "hand-cup interaction" action intention understanding task. Results: Task-related causal connectivity was found in gamma frequency band (30-45 Hz), primarily manifested as directed edges from sensorimotor to frontal areas in poststimulus 400-600 ms interval and directed links from frontal to parietal and temporal regions in 600-800 ms period. The analysis of event-related potential and source currents suggests that the change of inter-regional causality is related with functional transition of the brain from mirror matching to intention inference. The OPDC network modeling further finds that frontal area contains more inflow nodes in mirror network, whereas more outflow nodes in mentalizing network, with high betweenness centrality in temporally changing functional communities. Compared with intention-oriented actions, identification of unintelligible action intention particularly induces stronger OPDC from right superior frontal to inferior frontal gyrus and from sensorimotor to right frontotemporal regions during mentalizing inference process. Conclusion: These findings collectively suggest that, in the time ordering of information transfer within the directed networks, frontal area plays an important role of bridging hub between mirror and mentalizing systems, from maintaining and supervising perceptual information for mirror matching to controlling the mentalizing process for decoding other's action intention.

引言在理解他人的行动意图时,人脑的镜像系统和心智系统会在行动感知和意图推断过程中先后被激活。研究方法:为了揭示镜像系统和心智系统在这两个阶段中的关系,本脑电图研究采用时变正交部分定向相干(OPDC)的方法来评估 "手杯互动 "动作意图理解任务中镜像网络和心智网络之间的因果交互作用。结果发现在伽马频段(30-45 Hz)发现了与任务相关的因果连通性,主要表现为在刺激后 400-600 毫秒间隔内从感觉运动区到额叶区的有向边缘,以及在 600-800 毫秒期间从额叶区到顶叶区和颞叶区的有向联系。对事件相关电位和源流的分析表明,区域间因果关系的变化与大脑从镜像匹配到意向推理的功能转变有关。OPDC 网络建模进一步发现,额叶区在镜像网络中包含更多的流入节点,而在心智化网络中包含更多的流出节点,在时间变化的功能群落中具有较高的间度中心性。与以意向为导向的行动相比,在心智化推理过程中,识别不可理解的行动意向尤其会引起从右额叶上回到额叶下回以及从感觉运动区到右额颞区的更强的 OPDC。结论这些发现共同表明,在定向网络内信息传递的时间顺序中,额叶区在镜像系统和心智化系统之间起着重要的桥梁枢纽作用,从维护和监督镜像匹配的知觉信息到控制心智化过程以解码他人的行动意图。
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引用次数: 0
期刊
Brain connectivity
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