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Influence of chronic obstructive illness of the lungs on the current of the postpericardicotomy syndrome in patients after coronary artery bypass grafting 慢性阻塞性肺疾病对冠状动脉搭桥术患者心包切开术后综合征电流的影响
Pub Date : 2019-04-25 DOI: 10.15406/jlprr.2019.06.00204
Shlyk If, Sidorov Rv, Shchetko Vn, Sizyakina Lp, Shlyk Sv
One of the complications of aortocoronary bypass surgery is post-pericardiotomy syndrome, the development of which prolongs the length of stay in the hospital. It is known that this syndrome develops as a result of endothelial dysfunction and activation of the systemic inflammatory response. In this connection, it is necessary to compare the clinical data and the results of instrumental research methods to assess the effect of chronic obstructive pulmonary disease on the course of post-pericardicotomy syndrome. The study revealed that chronic obstructive pulmonary disease is not a predictor of the development of PCTS, but complicates its course.
冠状动脉搭桥手术的并发症之一是心包切开术后综合征,其发展延长了住院时间。众所周知,这种综合征的发展是由于内皮功能障碍和全身炎症反应的激活。因此,有必要比较临床资料和仪器研究方法的结果,以评估慢性阻塞性肺疾病对心包切开术后综合征病程的影响。该研究表明,慢性阻塞性肺疾病不是PCTS发展的预测因子,但会使其病程复杂化。
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引用次数: 0
Benefit and clinical characteristics after the use of nintedanib in idiopathic pulmonary fibrosis 尼达尼布治疗特发性肺纤维化的疗效和临床特点
Pub Date : 2019-03-29 DOI: 10.15406/jlprr.2019.06.00202
Herrera-García José Carlos, Arellano Montellano Ek Ixel, Jaramillo Arellano Luis Enrique, Espinosa Arellano Andrea
Introduction: Nintedanib is an approved antifibrotic agent for the treatment of idiopathic pulmonary fibrosis. (FPI) as monotherapy. To date, the evidence supports its effectiveness in this type of patients. Methodology: We present the case of a Mexican patient of 69 years with Idiopathic Pulmonary Fibrosis (IPF) treated with nintedanib for 52 weeks as monotherapy in a university hospital. Results: Before the 52 week period. There was a clear decrease in the patient's forced vital capacity (FVC) from 70% (2.14L) to 60% (1.83L). The treatment with nintedanib was initiated for a period of 12 months at a dose of 150 mg VO every 12 hrs. Lung function stabilized increasing from 60% (1.83L) to 70% (2.14L), the treatment was well tolerated. Only with presence of mild adverse effects without repercussions. Conclusion: We describe the successful case of a patient with Idiopathic Pulmonary Fibrosis after 52 weeks of treatment with Nintedanib, well tolerated with improved lung function, until now the antifibrotic therapy represents a safe and therapeutically option as monotherapy.
尼达尼布是一种被批准用于治疗特发性肺纤维化的抗纤维化药物。(FPI)作为单一疗法。迄今为止,证据支持其对这类患者的有效性。方法:我们报告了一名69岁的墨西哥特发性肺纤维化(IPF)患者在一所大学医院接受尼达尼布单药治疗52周的病例。结果:52周前。患者的强迫肺活量(FVC)从70% (2.14L)明显下降到60% (1.83L)。尼达尼布开始治疗12个月,剂量为150mg VO每12小时。肺功能稳定,由60% (1.83L)上升至70% (2.14L),治疗耐受性良好。只有轻微的副作用,没有不良反应。结论:我们描述了一个特发性肺纤维化患者在接受尼达尼布治疗52周后的成功病例,耐受性良好,肺功能改善,到目前为止,抗纤维化治疗作为单药治疗是一种安全且有效的选择。
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引用次数: 0
Alpha 1 antitrypsin deficiency: a rare allele in patients from south of Italy α 1抗胰蛋白酶缺乏症:意大利南部患者中一种罕见的等位基因
Pub Date : 2019-03-29 DOI: 10.15406/jlprr.2019.06.00203
Maddaloni V, P. N, M. F., Lanzo M, Darco D, Atripaldi L
Congenital α1-antitrypsin deficiency (AATD) is an autosomal recessive disorder, in Italy it is estimated that 1 in 5000 individuals may suffer from severe AATD. The AATD pathogenesis is directly related to gene mutations, which are highly polymorphic: in fact, more than 120 genetic variants closely associated with specific plasma glycoprotein concentrations have been identified. All the variants have a different clinical significance as they can cause an increase of occurrence of some pathologies such as emphysema, acute or chronic liver disease, cirrhosis, or liver failure. In particular, emphysema affects 54% of patients diagnosed with this deficit. The purpose of our study was to perform a mutational analysis of the AAT gene in order to highlight a genotype-serum correlation of AAT: we found subjects heterozygous for the rare allele PiMProcida and correlated its presence with a marked lowering of serum AAT levels.
先天性α - 1抗胰蛋白酶缺乏症(AATD)是一种常染色体隐性遗传病,在意大利,估计每5000人中就有1人可能患有严重的AATD。AATD的发病机制与基因突变直接相关,基因突变具有高度多态性:事实上,已经鉴定出120多种与特定血浆糖蛋白浓度密切相关的遗传变异。所有的变异都有不同的临床意义,因为它们可以导致一些病理的发生增加,如肺气肿、急性或慢性肝病、肝硬化或肝功能衰竭。特别是,54%被诊断患有这种缺陷的患者受到肺气肿的影响。我们研究的目的是对AAT基因进行突变分析,以突出AAT基因型与血清的相关性:我们发现受试者对罕见的等位基因PiMProcida杂合,并将其存在与血清AAT水平显著降低联系起来。
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引用次数: 1
Pulmonary tuberculosis and peptic ulcer disease association in geriatric patients 老年患者肺结核与消化性溃疡疾病的关系
Pub Date : 2019-03-26 DOI: 10.15406/jlprr.2019.06.00200
Graça Maria CASTRO VIANA
The geriatric population is predisposed to the development of pulmonary tuberculosis (PT), both by endogenous and exogenous factors. Regarding for peptic ulcer disease (PUD) in this same age group, the clinical manifestations are related to the loss of weight and to the depreciation of the general state; a situation that provokes reactivation of PT, causing a more severe clinical picture, not only due to the association of the two pathologies, but also by the age group itself. In this case report, we present a 97-year-old woman with an unexpected association of pulmonary tuberculosis and DUP.
由于内源性和外源性因素,老年人群易患肺结核(PT)。同一年龄组的消化性溃疡(PUD),临床表现与体重减轻、全身状态下降有关;引起PT重新激活的情况,导致更严重的临床表现,不仅由于两种病理的关联,而且由于年龄组本身。在这个病例报告中,我们提出了一个97岁的妇女与肺结核和DUP的意外关联。
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引用次数: 0
Faecopneumothorax revealing a neglected traumatic diaphragmatic hernia 肺气胸显示被忽视的创伤性膈疝
Pub Date : 2019-03-26 DOI: 10.15406/jlprr.2019.06.00201
B. Chaoui, I. Nassar, N. Moatassimbillah
Introduction: Tension fecopneumothoraxis a rare but serious complication of traumatic diaphragmatic hernias. The diagnosis of the hernia can be delayed from a few days to some years and will be made on occasion of complications representing the dramatic evolution of the “latent stage” of disease. Only few cases of post-traumatic faecopneumothorax are described in the literature. This clinical evolution is associated to a significant increase in morbidity (30–80% of cases). This is particularly the case with our patient. Case presentation: We report the case of a 26-year-old who had a trauma of the left hypochondrium about a year ago and who presented an acute intestinal occlusion, an X ray abdomen and chest was performed, showing abundant hydropneumothorax, thethoracoabdominal scan reveals an abundant effusion with heterogeneous density in the left pleural cavity, associated with an intrapleural hernia of the large intestine Discussion: Tension fecopneumothorax is a very rare complication of traumatic diaphragmatic hernia, only few cases are described in the literature, the mechanisms of the injury can blunt or penetrating, it occurs after intrapleural perforation of a strangulated colon, and very often its life threatening. Conclusion: According to our knowledge and review of the literature, Tension fecopneumothorax complicating a traumatic diaphragmatic hernia is very rare; the diagnosis is made by thoracic radiography and thoracoabdominalCT, which also allow orientation of the therapeutic attitude with non-negligible post-operative complications.
简介:张力性气胸是创伤性膈疝罕见但严重的并发症。疝气的诊断可以从几天推迟到几年,有时会出现并发症,代表疾病“潜伏阶段”的戏剧性演变。只有少数病例外伤后的粪便气胸在文献中被描述。这种临床演变与发病率的显著增加(30-80%的病例)有关。我们的病人尤其如此。病例介绍:我们报告一名26岁的患者,大约一年前左肋软骨创伤,表现为急性肠闭塞,腹部和胸部X线片显示大量气胸积液,胸腹扫描显示左侧胸膜腔大量密度不均的积液,并伴有大肠胸膜内疝。张力性气胸是外伤性膈疝的一种非常罕见的并发症,文献中仅报道了少数病例,其损伤机制可钝性或穿透性,发生于绞窄性结肠的胸膜内穿孔后,且常危及生命。结论:根据我们的知识和文献回顾,张力性气胸并发外伤性膈疝是非常罕见的;通过胸部x线摄影和胸腹ct进行诊断,这也可以确定治疗态度和不可忽视的术后并发症。
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引用次数: 0
Systemic lupus erythematosus presenting as stevens johnson syndrome in a thirty years old female: a case report 系统性红斑狼疮表现为史蒂文斯约翰逊综合征在一个30岁的女性:一个病例报告
Pub Date : 2019-02-28 DOI: 10.15406/jlprr.2019.06.00199
M. Mukarram
Background: SJS occurs almost exclusively secondary to drugs but very rarely, SLE can be an inciting factor for SJS without presence of an offending drug. The association is extremely rare, however few cases have been reported. Case presentation: We present a case report of a thirty year old female who presented to the rheumatology clinic with complaints of rash on her face, swelling of the lips and oral ulcers with severe hemorrhagic cheilitis. She also complained of persistent high grade fever with development of blisters on her face and oropharyngeal mucosa. She had been suffering from pain in multiple joints which did not respond to NSAIDs. A diagnosis of SLE presenting as SJS was established. Patient was given good supportive care, steroids, DMARDs and analgesics, to which she responded well and recovered. Conclusion: Stevens Johnson Syndrome is an uncommon, severe dermatological condition usually caused secondary to drugs. Secondary cause of the disease may rarely be co-existence of an autoimmune condition like SLE, as present in our patient.
背景:SJS几乎完全继发于药物,但非常罕见,SLE也可能是SJS的一个诱发因素,而没有致病药物的存在。这种联系是极其罕见的,但很少有病例被报道。病例介绍:我们提出一个病例报告,三十岁的女性谁提出了风湿病临床投诉皮疹在她的脸上,嘴唇肿胀和口腔溃疡严重出血性口炎。她还主诉持续高烧,面部和口咽黏膜出现水疱。她患有多个关节疼痛,对非甾体抗炎药没有反应。SLE的诊断表现为SJS。患者给予良好的支持性护理,类固醇,DMARDs和止痛药,她反应良好并恢复。结论:史蒂文斯约翰逊综合征是一种罕见的、严重的皮肤病,通常是由药物引起的。该疾病的继发原因可能很少是自身免疫性疾病(如SLE)的共存,正如本例患者所见。
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引用次数: 0
A correlation exists between normal breathing rate and watching horror movies 正常呼吸频率和看恐怖电影之间存在相关性
Pub Date : 2019-02-28 DOI: 10.15406/jlprr.2019.06.00198
M. Asif, M. Qadir
The reason of present research was to estimate somewhat relation between normal breathing rate and watching horror movies. Total 135 subjects were the participants of this project. The breathing rate is expressed as the total number of breaths a person receiving in 1 minute. The normal rate is 12 to 20 breaths per minute in adults. The respiration rate underneath 12 and overhead 25 is regarded as abnormal and it points to grim health problems. The situations that can vary normal respiratory rate are anxiety, fever, flu, air pollution, asthma, pneumonia, heart failure, lung disorder, drug overdosing and usage of narcotics. Now a days, number of people love viewing horror movie while some hatred them. There is an elongated list of such movies on internet. Scary movies have the physical and psychological effects on one’s mind. The most evident are anxiety and stress that can lead to high pulse rate and sweating. Such physical effects result in increase of respiration rate. In such situations, we inhale more oxygen and exhale more carbon dioxide. The member of the audience spots high breathing like performing a light exercise. The thrill of unknown and abrupt appearance of any terror initiates the body to groom against that fear. After-all above procedure, it was summarized that there was a significant interaction between normal breathing rate and watching horror movies.
本研究的目的是估计正常呼吸频率与观看恐怖电影之间的某种关系。本项目共纳入135名受试者。呼吸频率表示为一个人在一分钟内接受的呼吸总数。成年人的正常呼吸速率是每分钟12到20次。呼吸频率在12度以下和25度以上被认为是不正常的,预示着严重的健康问题。影响正常呼吸频率的情况包括焦虑、发烧、流感、空气污染、哮喘、肺炎、心力衰竭、肺部疾病、药物过量和使用麻醉品。如今,许多人喜欢看恐怖电影,而有些人则讨厌恐怖片。网上有很多这样的电影。恐怖电影对人的身心都有影响。最明显的是焦虑和压力会导致脉搏加快和出汗。这种物理效应导致呼吸速率的增加。在这种情况下,我们吸入更多的氧气,呼出更多的二氧化碳。观众注意到高亢的呼吸就像在做一项轻松的运动。任何未知和突然出现的恐怖的刺激,都促使身体去梳理以对抗这种恐惧。综上所述,我们可以总结出正常呼吸频率与观看恐怖片之间存在显著的交互作用。
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引用次数: 3
Results of coronary artery bypass grafting in patients with chronic obstructive lung disease 慢性阻塞性肺疾病患者冠状动脉旁路移植术的效果
Pub Date : 2019-02-28 DOI: 10.15406/jlprr.2019.06.00196
Shlyk If, Sidorov Rv, Shchetko Vn, Sizyakina Lp, Shlyk Sv
This work is relevant because it studies the effect of chronic obstructive pulmonary disease on the incidence of complications after coronary artery bypass grafting in patients with ischemic lung disease. 118 histories of patients, who underwent CABG under conditions of artificial circulation and without it, on a working heart, were analyzed. It was found that in patients with CABG under conditions of infarction and concomitant chronic obstructive pulmonary disease, the period of artificial ventilation was significantly longer among all the assessed complications and features of the postoperative period than in the group of patients with CABG performed on a working heart.
研究慢性阻塞性肺疾病对缺血性肺疾病患者冠状动脉搭桥术后并发症发生率的影响,具有重要意义。本文分析了118例在人工循环条件下和没有人工循环条件下在正常心脏上进行CABG的患者的病史。研究发现,在梗死合并慢性阻塞性肺疾病的CABG患者中,在所有评估的并发症和术后期特征中,人工通气时间明显长于在正常心脏上进行CABG的患者组。
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引用次数: 0
The connection between normal breathing and eye blinking 正常呼吸和眨眼之间的联系
Pub Date : 2019-02-26 DOI: 10.15406/jlprr.2019.06.00195
Muhammad Tanveer, Muhammad Imran Qadir
The main consult of this research was to check the relation between normal breathing and eye blinking. Totally 130 subjects were the part of this research. We measured the normal breathing rate of subjects by simple method. There must be a digital stop watch. First of all, we give a comfortable position to the subjects. We start counting after 10 minutes of rest, for accurate measurement. We started the stop watch and counted the breathing rate of every subject. Questionnaire was arranged to check the effect of breathing on eye blinking. We asked some question to the subjects and note their answers. This work can arouse the scientist to work more on this article. We made a table and calculate the averages and p values to check the relation. It was concluded that there was no scientific relation among normal breathing rate and eye blinking.
本研究的主要目的是检查正常呼吸与眨眼之间的关系。本研究共纳入130名受试者。我们用简单的方法测量了受试者的正常呼吸频率。必须有一个数字秒表。首先,我们给受试者一个舒适的姿势。我们在休息10分钟后开始计数,以便精确测量。我们启动秒表,计算每个实验对象的呼吸频率。采用问卷调查的方式,考察呼吸对眨眼的影响。我们问了受试者一些问题,并记下他们的回答。这项工作可以激发科学家们在这篇文章上做更多的工作。我们制作了一个表格,计算平均值和p值来检查关系。结论:正常呼吸频率与眨眼之间无科学关系。
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引用次数: 0
Analysis of A Panel Of Cytokines in BAL Fluids to Differentiate Controlled and Uncontrolled Asthmatics Using Machine Learning Model 利用机器学习模型分析BAL液中一组细胞因子以区分控制和非控制哮喘患者
Pub Date : 2019-01-01 DOI: 10.17554/J.ISSN.2412-2424.2019.05.44
Pooja Mr, Pushpalatha Mp
{"title":"Analysis of A Panel Of Cytokines in BAL Fluids to Differentiate Controlled and Uncontrolled Asthmatics Using Machine Learning Model","authors":"Pooja Mr, Pushpalatha Mp","doi":"10.17554/J.ISSN.2412-2424.2019.05.44","DOIUrl":"https://doi.org/10.17554/J.ISSN.2412-2424.2019.05.44","url":null,"abstract":"","PeriodicalId":91750,"journal":{"name":"Journal of lung, pulmonary & respiratory research","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78885941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
期刊
Journal of lung, pulmonary & respiratory research
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