Biomarkers in medicine最新文献

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NEAT1 and CHROMR lncRNAs: a promising diagnostic tool for diffuse large B-cell lymphoma especially in elderly patients. NEAT1和CHROMR lncRNAs：弥漫大B细胞淋巴瘤（尤其是老年患者）的有望诊断工具。

IF 2.2 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Biomarkers in medicine

Pub Date : 2024-09-12 DOI: 10.1080/17520363.2024.2389036

Ali Rajabi,Ali Saber,Joost Kluiver,Anke van den Berg,Mohammad Ali Hosseinpourfeizi,Reza Safaralizadeh

Background: Long non-coding (lnc) RNAs have crucial regulatory roles in molecular pathways, and their dysregulation is associated with the pathogenesis of malignancies such as Diffuse large B-cell lymphoma (DLBCL). Therefore, we aimed to study the NEAT1 and CHROMR expression in DLBCL and explore their association with clinicopathological characteristics.Methods & materials: DLBCL and non-tumor lymph node specimens were obtained to assess the expression levels.Results: NEAT1 and CHROMR expressions were significantly increased in DLBCL, and were linked with the age of DLBCL patients (aged >60). NEAT1 and CHROMR overexpression may serve as moderate-to-good diagnostic biomarkers, with NEAT1 and CHROMR exhibiting area under the curve values of 0.781 and 0.831, respectively.

背景：长非编码（lnc）RNA在分子通路中具有重要的调控作用，它们的失调与弥漫大B细胞淋巴瘤（DLBCL）等恶性肿瘤的发病机制有关。因此，我们旨在研究 NEAT1 和 CHROMR 在 DLBCL 中的表达，并探讨它们与临床病理特征的关系：获取 DLBCL 和非肿瘤淋巴结标本以评估其表达水平：结果：NEAT1和CHROMR在DLBCL中的表达明显升高，且与DLBCL患者的年龄（大于60岁）有关。NEAT1和CHROMR的过表达可作为中度至良好的诊断生物标记物，NEAT1和CHROMR的曲线下面积值分别为0.781和0.831。

引用次数: 0

Naples prognostic score as a predictor of mortality in surgical aortic valve replacement. 那不勒斯预后评分作为外科主动脉瓣置换术死亡率的预测指标。

IF 2.2 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Biomarkers in medicine

Pub Date : 2024-09-12 DOI: 10.1080/17520363.2024.2389035

Onur Erdoğan,Tuğba Erdoğan,Cafer Panç,İsmail Gürbak,Mehmet Ertürk

Aim: Investigating the impact of nutritional and inflammatory status, assessed by the Naples-Prognostic-Score (NPS), on postoperative mortality in 173 older adults undergoing surgical aortic valve replacement(SAVR) for aortic stenosis(AS).Methods: Retrospective study calculating NPS from neutrophils/lymphocytes, lymphocytes/monocytes, total cholesterol and serum albumin.Results: Mean age was 69.39 ± 6.153 with 45.1% females. The post-operative mortality was 23.7% over a follow-up period of 50 ± 31 months. The 1-month mortality rate is 2.89%. High NPS significantly associated with increased mortality; multivariate logistic regression confirmed its independence (odds-ratio:3.494, 95% confidence-interval:1.555-7.849, p = 0.002). NPS cutoff of 2 showed 73.2% sensitivity, 56.8% specificity and area-under-the-curve of 0.758 for predicting all-cause mortality. Kaplan-Meier analysis supported lower NPS correlating with better survival.Conclusion: NPS independently predicts postoperative mortality in SAVR patients.

目的：在173名因主动脉瓣狭窄（AS）接受主动脉瓣置换术（SAVR）的老年人中，通过那不勒斯诊断评分（NPS）评估营养和炎症状态对术后死亡率的影响：回顾性研究：根据中性粒细胞/淋巴细胞、淋巴细胞/单核细胞、总胆固醇和血清白蛋白计算NPS：平均年龄（69.39±6.153）岁，女性占 45.1%。在 50 ± 31 个月的随访期间，术后死亡率为 23.7%。1 个月死亡率为 2.89%。高 NPS 与死亡率增加明显相关；多变量逻辑回归证实了其独立性（赔率：3.494，95% 置信区间：1.555-7.849，P = 0.002）。NPS 临界值为 2 时，预测全因死亡率的灵敏度为 73.2%，特异度为 56.8%，曲线下面积为 0.758。Kaplan-Meier分析支持较低的NPS与较好的生存率相关：结论：NPS可独立预测SAVR患者的术后死亡率。

引用次数: 0

Urinary cystatin-C and urinary NGAL associated with sepsis predicts longer hospital stay in premature newborns. 与败血症相关的尿胱抑素 C 和尿 NGAL 可预测早产新生儿住院时间的延长。

IF 2.2 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Biomarkers in medicine

Pub Date : 2024-09-12 DOI: 10.1080/17520363.2024.2377532

Joycilene da Silva Barbosa,Gdayllon Cavalcante Meneses,Luan Rebouças Castelo,Geraldo Bezerra da Silva Júnior,Alice Maria Costa Martins,Elizabeth De Francesco Daher,Tiago Lima Sampaio,Amanda de Oliveira Gomes,Suzzy Maria Carvalho Dantas,Arthur da Silva Rebouças,Paula Roberta de Lima,Nicole Coelho Lopes,Mateus Edson da Silva,Mac Dionys Rodrigues da Costa,Ana Amelia Reis Jereissati,Victoria Queiroz Ramos,Rosângela Pinheiro Gonçalves Machado,Romélia Pinheiro Gonçalves Lemes

Aim: To evaluate the urinary biomarkers related to sepsis in preterm newborns (NBs) and to investigate the predictive capacity of these biomarkers for a longer hospital stay.Methods: Serum and urine were collected from 27 healthy NBs, 24 NBs with neonatal infection without sepsis and 11 NBs with sepsis for the measurement of sindecan-1, lipocalin associated with urinary neutrophil gelatinase (uNGAL), urinary cystatin-C (uCysC) and urinary kidney injury molecule-1.Results: Levels of uNGAL and urinary cystatin-C were elevated in NBs with sepsis and neonatal infection, and uNGAL was significant predictor of hospital stay longer than 30 days (odds ratio: 1.052; 95% CI: 1.012-1.093; p = 0.01).Conclusion: uNGAL was associated with sepsis in preterm NBs and was useful to predict extended hospital stay.

目的：评估与早产新生儿（NBs）败血症有关的尿液生物标志物，并研究这些生物标志物对延长住院时间的预测能力：方法：采集27名健康新生儿、24名未患败血症的新生儿感染患者和11名患败血症的新生儿的血清和尿液，测量信迪康-1、与尿中性粒细胞明胶酶相关的脂钙蛋白（uNGAL）、尿胱抑素-C（uCysC）和尿肾损伤分子-1：结论：uNGAL与早产新生儿败血症有关，可用于预测住院时间的延长。

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引用次数: 0

Genetic polymorphisms of LMX1B and MLXIP are associated with hip osteoarthritis in the Chinese population. 中国人群中 LMX1B 和 MLXIP 的遗传多态性与髋关节骨关节炎有关。

IF 2.2 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Biomarkers in medicine

Pub Date : 2024-09-12 DOI: 10.1080/17520363.2024.2389030

Chuan Chen,Desheng Kong,Pin Wang,Ming Li,Ranran Gui

Aims: A large genome-wide analyses of UK Biobank data reported 15 novel loci associated with the susceptibility of hip osteoarthritis (HOA). We aimed to replicate the association of these loci with HOA in the Chinese population.Methods: A total of 13 Single Nucleotide Polymorphisms were genotyped in 892 HOA patients and 1123 healthy controls.Results: The risk allele frequency of rs62578127 and rs11059094 was significantly higher in the patients than in the controls. The mRNA expression of LMX1B (p = 0.01) and MLXIP (p = 0.001) were significantly increased in HOA tissues.Conclusion: We successfully replicated two novel susceptible loci of HOA and further characterized two potential causative genes.

目的：英国生物库数据的一项大型全基因组分析报告了15个与髋关节骨关节炎（HOA）易感性相关的新位点。我们的目的是在中国人群中复制这些位点与髋关节炎的相关性：方法：在 892 名髋关节炎患者和 1123 名健康对照者中对 13 个单核苷酸多态性位点进行了基因分型：结果：患者中rs62578127和rs11059094的风险等位基因频率明显高于对照组。在 HOA 组织中，LMX1B（p = 0.01）和 MLXIP（p = 0.001）的 mRNA 表达量明显增加：我们成功地复制了 HOA 的两个新的易感基因位点，并进一步鉴定了两个潜在的致病基因。

引用次数: 0

Insights into the baseline blood pH homeostasis at admission and the risk of in-hospital mortality in COVID-19 patients. 洞察 COVID-19 患者入院时的血液 pH 平衡基线和院内死亡风险。

IF 2.2 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Biomarkers in medicine

Pub Date : 2024-09-10 DOI: 10.1080/17520363.2024.2395800

Mary Pulgar-Sánchez,Kevin Chamorro,Claudio Casella,Santiago J Ballaz

Aim: A laboratory finding in critically ill COVID-19 patients is blood academia (pH <7.35). We investigated its cause in connection with the admission baseline blood pH homeostasis.Patients & methods: We retrospectively monitored the baseline blood pH homeostasis of 1215 COVID-19 patients who were admitted with pneumonia using data-driven knowledge. Two categories of patients were identified: non-survivors (107) and survivors (1108).Results: Non-survivors showed greater levels of lactate and lower blood pH, saturation, and partial pressure of oxygen than survivors. A bivariate Spearman's correlation matrix showed that the [HCO3-]/pCO2 and pCO2 of non-survivors exhibited an unmatched connection, but not in the survivor group. When comparing non-survivors to survivors, the dendrograms derived from the bivariate comparison matrix showed differences in gasometry parameters like blood pH, [HCO3-]/pCO2 ratio, anion gap and pO2.Conclusion: The little variations in the gasometry readings between survivors and non-survivors upon admission suggested abnormal changes in the complementary renal and respiratory systems that bring blood pH back to normal. In advanced COVID-19, modest blood acid-base imbalances could become blood acidemia if these compensatory strategies were overused. Data-driven monitoring of acid-base parameters may help predict abnormal blood pH and the advancement of metabolic acidemia before it is too late.

目的：COVID-19重症患者的一个实验室发现是血液pH值异常（pH值<7.35）。患者和方法：我们对 1215 名 COVID-19 重症患者进行了回顾性监测：我们利用数据驱动知识，对 1215 名因肺炎入院的 COVID-19 患者的基线血液 pH 平衡进行了回顾性监测。结果：非存活患者的血液pH平衡水平高于存活患者，而存活患者的血液pH平衡水平低于非存活患者：结果：与幸存者相比，非幸存者的乳酸水平更高，血液 pH 值、饱和度和氧分压更低。双变量斯皮尔曼相关矩阵显示，非幸存者的[HCO3-]/pCO2 和 pCO2 显示出不匹配的联系，而幸存者组则没有。将非幸存者与幸存者进行比较时，从双变量比较矩阵得出的树枝图显示了血液 pH 值、[HCO3-]/pCO2 比值、阴离子间隙和 pO2 等气体测量参数的差异：幸存者和非幸存者入院时的气体测量读数差异很小，这表明肾脏和呼吸系统的互补性发生了异常变化，从而使血液 pH 值恢复正常。在晚期 COVID-19 中，如果过度使用这些代偿策略，轻微的血液酸碱失衡可能会变成血液酸血症。数据驱动的酸碱参数监测有助于预测血液 pH 值异常和代谢性酸血症的进展，以免为时过晚。

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引用次数: 0

Exploring the correlation between homocysteine, red blood cell folate and MTHFRC677T genotypes with female infertility. 探讨同型半胱氨酸、红细胞叶酸和 MTHFRC677T 基因型与女性不孕的相关性。

IF 2.2 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Biomarkers in medicine

Pub Date : 2024-09-10 DOI: 10.1080/17520363.2024.2394386

Xueyun You,Zhaozhen Zhang,Yonghua Xu,Bicheng Yang,Shuhui Huang,Yongyi Zou,Feng Zhao,Chuanxin Feng,Haorui Lao,Huizhen Yuan,Yanqiu Liu,Min Wu

Aim: To investigate the association between serum homocysteine (HCY) levels, red blood cell folate (RCF) levels, methylenetetrahydrofolate reductase (MTHFR) gene polymorphism and infertility.Materials & methods: Serum HCY and RCF levels and C677T polymorphism of MTHFR gene were analyzed in 149 infertile patients and 223 women of normal reproductive age with healthy childbirth history.Results: The HCY level of MTHFR C677T TT genotype infertility patients was higher than that of women of normal reproductive age, while the RCF level was not significantly different between the two groups.Conclusion: Serum HCY levels increased in infertility patients, and the MTHFR C677T TT genotype in childbearing-aged women are associated with a higher risk of infertility. The results showed that HCY level and MTHFR C677T genotype were closely related to infertility.

目的：研究血清同型半胱氨酸（HCY）水平、红细胞叶酸（RCF）水平、亚甲基四氢叶酸还原酶（MTHFR）基因多态性与不孕症之间的关系：对149名不孕症患者和223名有健康生育史的正常育龄妇女的血清HCY和RCF水平以及MTHFR基因的C677T多态性进行了分析：结果：MTHFR C677T TT基因型不孕症患者的HCY水平高于正常育龄妇女，而RCF水平在两组间无显著差异：结论：不孕症患者的血清HCY水平升高，育龄妇女的MTHFR C677T TT基因型与不孕症的高风险相关。结果表明，HCY水平和MTHFR C677T基因型与不孕症密切相关。

引用次数: 0

The long-term impact of increased red blood cell distribution width detected during hospitalization for heart failure. 心力衰竭住院期间发现的红细胞分布宽度增加的长期影响。

IF 2.2 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Biomarkers in medicine

Pub Date : 2024-09-10 DOI: 10.1080/17520363.2024.2395237

Otto Mayer,Jan Bruthans,Josef Jirák,Jan Filipovský

Aim: We determined the long-term role of increased RDW (red blood cell distribution width) detected during cardiac decompensation.Methods: We followed 3697 patients [mean age 71.4 years (±SD 10.1), 59.1% males] hospitalized for acute heart failure (HF) and assessed the five-year all-cause mortality risk associated with tertiles of RDW.Results: Patients with RDW in the top tertile showed roughly twofold higher 5-year mortality risk than those in the bottom tertile. The association remained significant not only after adjustments for potential covariates but even if we excluded patients who deceased during the first year of follow-up [HRR 1.76 (95% CIs:1.42-2.18), p < 0.0001].Conclusion: The high degree of anisocytosis represents an independent predictor of poor prognosis in HF patients, even long-term after an acute manifestation.

目的：我们确定了在心脏失代偿期发现的红细胞分布宽度（RDW）增加的长期作用：我们随访了 3697 名因急性心力衰竭（HF）住院的患者（平均年龄 71.4 岁（±SD 10.1），59.1% 为男性），并评估了与 RDW 四分位数相关的五年全因死亡风险：结果：RDW最高三分位数患者的5年死亡风险比最低三分位数患者高出约两倍。这种关联不仅在调整了潜在的协变量后仍然显著，而且即使我们排除了在随访第一年内死亡的患者[HRR 1.76 (95% CIs:1.42-2.18), p < 0.0001]：高度异形细胞增多是心房颤动患者预后不良的独立预测因素，即使在急性表现后的长期随访中也是如此。

引用次数: 0

RAP1-GTPase immunostaining is altered in human precancerous and cancerous cervical lesions. 人类癌前病变和癌症宫颈病变中的 RAP1-GTPase 免疫染色发生了改变。

IF 2.2 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Biomarkers in medicine

Pub Date : 2024-09-10 DOI: 10.1080/17520363.2024.2394384

Paula Cristina de Vasconcelos,Tulio Resende Freitas,Lara Verônica de Araújo Lopes,Larissa Rodrigues Peixoto,Marcelo Pascoal Xavier,Anna Carolina Cançado Figueiredo,Karolina Lopes Dias,Jaqueline Germano de Oliveira,Paulo Guilherme de Oliveira Salles,Annamaria Ravaro Vago,Adriano de Paula Sabino,Maria Gabrielle de Lima Rocha

Aim: This study investigated RAP1 immunostaining variation in different cell types during CC progression.Methods: Paraffin-embedded cervical tissues from 101 patients were categorized into control, pre-neoplastic and neoplastic groups. RAP1 immunolocalization, HPV detection and genotyping were performed. A semiquantitative immunoreactive score was employed to compare labeling intensity, cellular localization, nuclear labeling, percentage and distribution of reactive cells.Results: 73% (72/99) of cervical specimens were HPV+. RAP1 was localized in the nucleus and cytoplasm of all samples. Cytoplasmic RAP1 immunoscore was higher than nuclear score in all CC groups. RAP1 intensity increased with lesion severity. SCC samples exhibited predominantly intense RAP1 immunostaining.Conclusion: RAP1 is an efficient biomarker for detecting invasive CC lesions but has limited utility in distinguishing SCC grades.

目的：本研究探讨了RAP1免疫染色在CC进展过程中不同细胞类型中的变化：方法：101 例患者的石蜡包埋宫颈组织被分为对照组、肿瘤前组和肿瘤组。进行 RAP1 免疫定位、HPV 检测和基因分型。采用半定量免疫反应评分法比较标记强度、细胞定位、核标记、反应细胞的百分比和分布：73%（72/99）的宫颈标本为 HPV+。RAP1定位于所有样本的细胞核和细胞质中。在所有 CC 组中，细胞质 RAP1 免疫评分均高于细胞核评分。RAP1 的强度随病变严重程度而增加。SCC样本主要表现出强烈的RAP1免疫染色：结论：RAP1是检测浸润性CC病变的有效生物标记物，但在区分SCC等级方面作用有限。

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引用次数: 0

The association between HbA1c/C-peptide levels and short-term mortality in patients diagnosed with myocardial infarction. 确诊为心肌梗死患者的 HbA1c/C 肽水平与短期死亡率之间的关系。

IF 1.9 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Biomarkers in medicine

Pub Date : 2024-08-17 Epub Date: 2024-08-05 DOI: 10.1080/17520363.2024.2380248

Sefa Erdi Ömür, Emin Koyun, Gökhan Cabri, Çağri Zorlu

Introduction: In this study, we aimed to investigate the effect of HbA1C/C-peptide ratio on short-term mortality (this period is defined as 30 days after diagnosis) in the patients with myocardial infarction.Materials & Methods: Around 3245 patients who were admitted due to ST-elevation myocardial infarction (STEMI) and non-ST-elevation myocardial infarction underwent primary percutaneous coronary intervention between October 2020 and 2024 were included in this study.Results: In the receiver operating characteristic analysis, the predictive power of the HCR score for mortality in ST-elevation myocardial infarction patients was determined to be 83% sensitivity and 81% specificity. In non-ST-elevation myocardial infarction, this was determined to be 78% sensitivity and 75% specificity.Conclusion: The HbA1C/C-peptide ratio score can predict poor clinical outcomes early, reducing mortality and morbidity in patients with myocardial infarction.

简介本研究旨在探讨 HbA1C/C 肽比值对心肌梗死患者短期死亡率（诊断后 30 天）的影响。材料与方法：本研究纳入了 2020 年 10 月至 2024 年期间因 ST 段抬高型心肌梗死（STEMI）和非 ST 段抬高型心肌梗死而入院接受初次经皮冠状动脉介入治疗的约 3245 例患者。研究结果接受者操作特征分析显示，HCR评分对ST段抬高型心肌梗死患者死亡率的预测能力为83%的敏感性和81%的特异性。在非 ST 段抬高型心肌梗死患者中，灵敏度为 78%，特异度为 75%。结论HbA1C/C 肽比值评分可及早预测不良临床结果，降低心肌梗死患者的死亡率和发病率。

引用次数: 0

Diagnostic value of miR-200 family in non-small cell lung cancer: a meta-analysis miR-200 家族在非小细胞肺癌中的诊断价值：一项荟萃分析

IF 2.2 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Biomarkers in medicine

Pub Date : 2024-05-16 DOI: 10.2217/bmm-2024-0087

Zhen Ling, Lichang Yang

Aim: To investigate the diagnostic potential of the miR-200 family for early detection in non-small cell lung cancer (NSCLC). Materials & methods: A systematic search was conducted of PubMed, Embase and Web of Science databases to identify studies of the miR-200 family in NSCLC. Sixteen studies meeting the inclusion criteria were included in the analysis with a total of 20 cohorts. Results: The combined sensitivity and specificity reached 73% and 85%, with an area under the curve of 0.83. Notably, miR-200b introduced heterogeneity. Subgroup analysis highlighted miR-200a and miR-141 as more sensitive, while blood-derived miRNAs showed slightly lower accuracy. Conclusion: The miR-200 family, predominantly assessed in blood, exhibits significant diagnostic potential for NSCLC, especially in distinguishing it from benign diseases.

目的：研究 miR-200 家族在非小细胞肺癌（NSCLC）早期检测中的诊断潜力。材料与方法：对 PubMed、Embase 和 Web of Science 数据库进行了系统检索，以确定有关 miR-200 家族在非小细胞肺癌中应用的研究。符合纳入标准的 16 项研究被纳入分析，共有 20 个队列。结果显示综合灵敏度和特异性分别达到 73% 和 85%，曲线下面积为 0.83。值得注意的是，miR-200b 带来了异质性。亚组分析显示，miR-200a 和 miR-141 更为敏感，而血液来源的 miRNA 的准确性略低。结论主要在血液中评估的 miR-200 家族对 NSCLC 具有显著的诊断潜力，尤其是在区分 NSCLC 与良性疾病方面。

引用次数: 0

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