Brain Stimulation最新文献

英文中文

Effects of cue-synchronized parietal cathodal tDCS on internet gaming disorder: A randomized double-blind sham-controlled trial 线索同步顶叶阴极tDCS对网络游戏障碍的影响：一项随机双盲假对照试验。

IF 8.4 1区医学 Q1 CLINICAL NEUROLOGY

Brain Stimulation

Pub Date : 2025-11-01 DOI: 10.1016/j.brs.2025.10.025

Yixuan Song , Yuchen Huang , Qihong Zheng , Xiaoqin Yang , Yang Guo , Yanan Geng , Huixing Gou , Junjie Bu , Tianye Jia , Guangdong Zhou , Lin Lu , Jie Shi , Yan Sun

Background and objectives

Internet Gaming Disorder (IGD) is prevalent with limited treatment efficacy. Targeting reducing craving triggered by gaming cues is a critical therapeutic objective. This study aimed to establish optimized electroencephalography (EEG) biomarkers for IGD and develop a novel targeted neuromodulation protocol.

Methods

In the exploratory study, the optimized EEG indicators of IGD diagnose were identified through machine learning models based on event-related potential (ERP) and band power during game cue exposure across two independent datasets (Dataset 1: twenty-five IGD, twenty-two Recreational Game Users, twenty-eight non-gaming Healthy Controls (HC); Dataset 2: twenty-three IGD and twenty-three HC). Subsequently, in the intervention study, a double-blind randomized trial was conducted on forty-six IGD participants to compare active and sham transcranial direct current stimulation (tDCS) targeting the region where the optimized EEG marker was located—central parietal lobe (Pz). Active stimulation (1.5 mA, 20 min, 2 days) was applied during cue exposure (cathode: Pz; anode: right trapezius).

Results

Parieto-occipital P300 (peaked at Pz, IGD > HC) during game reactivity emerged as novel optimized EEG indicators for IGD discrimination (accuracy>80 %), linked to craving. Then, Pz targeted cathodal tDCS synchronized with game cue exposure could significantly reduce craving (p < 0.001), gaming time (p < 0.001), and P300 alpha (p = 0.048) after intervention and at 1–4 weeks follow-ups, with concomitant improvement of decision-making in the active group. Importantly, these effects generalized to unpresented gaming cues. Besides, we identified baseline delta power at Pz during gaming cues as a significant predictor for treatment effects.

Conclusion

Our findings establish cue-synchronized tDCS as an effective intervention approach and position the Pz as a novel therapeutic target for IGD neuromodulation.

背景和目的：网络游戏障碍（IGD）普遍存在，但治疗效果有限。以减少由游戏线索引发的渴望为目标是一个关键的治疗目标。本研究旨在建立优化的IGD脑电图（EEG）生物标志物，并开发一种新的靶向神经调节方案。方法：在探索性研究中，通过基于事件相关电位（ERP）和游戏线索暴露时频带功率的机器学习模型，确定了两个独立数据集(数据集1:25名IGD， 22名休闲游戏用户，28名非游戏健康对照组；数据集2:23个IGD和23个HC)。随后，在干预研究中，对46名IGD参与者进行了双盲随机试验，比较针对优化EEG标记所在区域-中央顶叶（Pz）的主动和假性经颅直流电刺激（tDCS）。在提示暴露期间，施加主动刺激（1.5 mA， 20分钟，2天）（阴极：Pz；阳极：右斜方肌）。结果：在游戏反应期间，顶枕P300（峰值在Pz， IGD>HC）成为与渴望相关的IGD辨别（准确率>80%）的新的优化EEG指标。结论：我们的研究结果证实了线索同步tDCS是一种有效的干预方法，并将Pz定位为IGD神经调节的一种新的治疗靶点。

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引用次数: 0

Evaluation of DBS computational modeling methodologies using in-vivo electrophysiology in Parkinson's disease 帕金森病患者体内电生理DBS计算建模方法的评估。

IF 8.4 1区医学 Q1 CLINICAL NEUROLOGY

Brain Stimulation

Pub Date : 2025-11-01 DOI: 10.1016/j.brs.2025.10.022

Seyyed Bahram Borgheai , Bryan Howell , Faical Isbaine , Angela M. Noecker , Enrico Opri , Benjamin B. Risk , Cameron C. McIntyre , Svjetlana Miocinovic

Background

Optimizing deep brain stimulation (DBS) parameter settings requires postoperative adjustments through a time-consuming trial-and-error process. As such, researchers have been developing computational models to guide DBS programming. Despite growing interest in image-guided DBS technology, and recent adoption into clinical practice, the direct validation of the prediction accuracy remains limited.

Objective

The objective of this study was to establish a comparative framework for validating the accuracy of various DBS computational modeling methodologies in predicting the activation of clinically relevant pathways using in vivo measurements from PD patients undergoing subthalamic (STN) DBS surgery.

Methods

In this study, we compared the accuracy of six computational modeling variations for predicting the activation of the corticospinal/bulbar tract (CSBT) and cortico-subthalamic hyperdirect pathway (HDP) using very short- (<2 ms) and short-latency (2–4 ms) cortical evoked potentials (cEPs). We constructed the variations using three key factors: modeling method (Driving Force [DF] vs. Volume of Tissue Activated [VTA]), imaging space (native vs. normative), and anatomical representation (pathway vs. structure). The model performances were quantified using the coefficient of determination (R²) between the cEP amplitudes and percent pathway or structure activation.

Results

We compared model accuracy for 11 PD patients. The DF-Native-Pathway model was the most accurate method for quantitatively predicting experimental subcortical pathway activations. Additionally, our analysis showed that using normative brain space significantly diminished the accuracy of model predictions.

Conclusion

The choice of methodology should depend on the specific application and the required level of precision for the intended analysis. However, model parameters should be optimized to accurately predict known experimental activation measures.

背景：优化脑深部刺激（DBS）的参数设置需要通过一个耗时的反复试验过程进行术后调整。因此，研究人员一直在开发计算模型来指导DBS编程。尽管人们对图像引导的DBS技术越来越感兴趣，并且最近应用于临床实践，但对预测准确性的直接验证仍然有限。目的：本研究的目的是建立一个比较框架，以验证各种DBS计算建模方法在预测临床相关通路激活方面的准确性，这些方法使用的是接受下丘脑（STN） DBS手术的PD患者的体内测量。方法：在这项研究中，我们比较了六种计算模型的准确性，用于预测皮质脊髓/球束（CSBT）和皮质-丘脑下超直接通路（HDP）的激活，使用cEP振幅和百分比通路或结构激活之间的极短间隔(2)。结果：我们比较了11例PD患者的模型准确性。DF-Native-Pathway模型是定量预测实验皮层下通路激活最准确的方法。此外，我们的分析表明，使用规范的大脑空间显著降低了模型预测的准确性。结论：方法学的选择应取决于具体应用和预期分析所需的精度水平。然而，为了准确预测已知的实验激活措施，需要对模型参数进行优化。

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引用次数: 0

Letter to the Editor in response to “Brain injury during focused ultrasound neuromodulation for substance use disorder” 致编辑的回应“聚焦超声神经调节治疗物质使用障碍期间的脑损伤”的信。

IF 8.4 1区医学 Q1 CLINICAL NEUROLOGY

Brain Stimulation

Pub Date : 2025-11-01 DOI: 10.1016/j.brs.2025.11.004

Kim Butts Pauly

引用次数: 0

TMS-induced modulation of brain networks and its associations to rTMS treatment for depression: a concurrent fMRI-EEG-TMS study 经颅磁刺激诱导的脑网络调节及其与经颅磁刺激治疗抑郁症的关联：fMRI-EEG-TMS同步研究。

IF 8.4 1区医学 Q1 CLINICAL NEUROLOGY

Brain Stimulation

Pub Date : 2025-11-01 DOI: 10.1016/j.brs.2025.10.013

Hengda He , Xiaoxiao Sun , Jayce Doose , Josef Faller , James R. McIntosh , Golbarg T. Saber , Sarah Huffman , Linbi Hong , Spiro P. Pantazatos , Han Yuan , Lisa M. McTeague , Robin I. Goldman , Truman R. Brown , Mark S. George , Paul Sajda

Introduction

Transcranial magnetic stimulation (TMS) over the left dorsolateral prefrontal cortex (L-DLPFC) is an established intervention for treatment-resistant depression (TRD), yet the underlying therapeutic mechanisms remain not fully understood.

Methods

This study employs an integrative approach that combines TMS with concurrent functional magnetic resonance imaging (fMRI) and electroencephalography (EEG), aimed at assessing the acute/immediate effects of TMS on brain network dynamics and their correlation with clinical outcomes. Furthermore, this study explored the brain-state dependent effects of TMS, as the brain-state indexed by the phase of EEG prefrontal alpha oscillation.

Results

Our study demonstrates that TMS acutely modulates connectivity within vital brain circuits, particularly the cognitive control and default mode networks. We found that the baseline TMS-evoked responses in the cognitive control and limbic networks significantly predicted clinical improvement in patients receiving a novel EEG-synchronized repetitive TMS treatment. Clinical outcomes in this novel treatment were linked to state-specific TMS-modulated functional connectivity within a pivotal brain circuit of the L-DLPFC and the posterior subgenual anterior cingulate cortex within the limbic system.

Conclusions

These findings contribute to our understanding of the therapeutic effects underlying TMS treatment in depression and support the potential of assessing state-dependent TMS effects. This study emphasizes the importance of personalized timing of TMS for optimizing target engagement of specific clinically relevant brain circuits. Our results are crucial for future research into the development of personalized neuromodulation therapies for TRD patients.

导读：经颅磁刺激（TMS）在左背外侧前额叶皮层（L-DLPFC）是一种确定的治疗难治性抑郁症（TRD）的干预措施，但其潜在的治疗机制尚不完全清楚。方法：本研究采用经颅磁刺激与并发功能磁共振成像（fMRI）和脑电图（EEG）相结合的综合方法，旨在评估经颅磁刺激对脑网络动力学的急性/即时影响及其与临床结果的相关性。此外，本研究还探讨了经颅磁刺激的脑状态依赖效应，即通过脑电图前额叶α振荡的相位来指示脑状态。结果：我们的研究表明，经颅磁刺激可以显著调节重要脑回路的连通性，特别是认知控制和默认模式网络。我们发现，认知控制和边缘网络的基线TMS诱发反应显著预测了接受脑电图同步重复TMS治疗的患者的临床改善。我们发现，这种新疗法的临床结果与大脑边缘系统中L-DLPFC和后亚属前扣带皮层的关键脑回路中特定状态的tms调节的功能连接有关。结论：这些发现有助于我们理解经颅磁刺激治疗抑郁症的治疗效果，并支持评估状态依赖性经颅磁刺激效果的潜力。本研究强调了个性化的经颅磁刺激时间对于优化特定临床相关脑回路的目标参与的重要性。我们的结果对未来TRD患者个性化神经调节疗法的发展研究至关重要。

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引用次数: 0

An in vivo model for transcranial direct current stimulation of the motor cortex in awake mice 清醒小鼠经颅直流电刺激运动皮质的体内模型

IF 8.4 1区医学 Q1 CLINICAL NEUROLOGY

Brain Stimulation

Pub Date : 2025-11-01 DOI: 10.1016/j.brs.2025.10.018

Carlos Andrés Sánchez-León , Pablo Alejandro Reyes-Velasquez , Christoph van Thriel , Michael A. Nitsche

Background

Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique mainly used in humans, in which weak direct currents are applied over the scalp to alter cortical excitability and induce neuroplasticity. Previous studies have demonstrated the value of tDCS for modulating sensory, motor, and cognitive functions, nevertheless, knowledge about how externally applied electric fields affect different components of neuronal networks is still incomplete, and in vivo animal models, which are required for a deeper understanding, are not fully developed. To evaluate the impact of tDCS on cortical excitability, many human experiments assess motor evoked potentials elicited by motor cortex (M1) stimulation.

Methods

To develop a related in vivo animal model, we recorded electrical activity in M1 of alert mice during and after administration of tDCS over M1. M1 excitability was chronically recorded from layers 2–3, layer 5 and layer 6, evoked by stimulation of the ventral lateral nucleus of the thalamus (VAL). M1-tDCS was applied at 100 and 200 μA for 5 s to test the acute effects on neuronal excitability, and for 15 min to induce after-effects.

Results

Acute M1-tDCS increased and decreased the amplitude of VAL-evoked potentials in a polarity-, layer- and intensity-dependent manner. For 15 min of anodal or cathodal tDCS, a similar polarity- and intensity-dependent modulation of VAL-evoked potential amplitudes during the 15 min of stimulation was observed. After tDCS was switched off, the highest intensity of anodal stimulation induced a significant excitability enhancement during at least 2 h after stimulation, whereas the after-effects of cathodal tDCS were less pronounced.

Conclusions

The current study demonstrates the feasibility of a mouse model of M1-tDCS to accomplish similar modulatory effects of tDCS on cortical excitability as observed in human experiments. A proper adjustment of tDCS parameters, as compared to application in humans, is however required to obtain these translational effects since a higher density current was necessary in this study to obtain effects comparable to those achieved in humans.

经颅直流电刺激（tDCS）是一种主要用于人类的非侵入性脑刺激技术，通过在头皮上施加微弱的直流电来改变皮层的兴奋性并诱导神经可塑性。先前的研究已经证明了tDCS在调节感觉、运动和认知功能方面的价值，然而，关于外电场如何影响神经元网络的不同组成部分的知识仍然不完整，并且需要更深入了解的体内动物模型尚未完全开发。为了评估tDCS对皮层兴奋性的影响，许多人体实验评估了运动皮层（M1）刺激引发的运动诱发电位。方法建立相应的体内动物模型，记录tDCS对M1的作用期间和作用后，清醒小鼠M1的电活动。通过刺激丘脑腹侧核（VAL），从第2-3层、第5层和第6层长期记录M1兴奋性。M1-tDCS分别在100和200 μA下作用5 s，观察其对神经元兴奋性的急性影响，15 min诱导后效。结果急性M1-tDCS使val诱发电位呈极性依赖性、层依赖性和强度依赖性增加和减少。对于15分钟的阳极或阴极tDCS，在15分钟的刺激期间观察到类似的极性和强度依赖性的val诱发电位振幅调制。在tDCS关闭后，最高强度的阳极刺激在刺激后至少2小时内诱导了显著的兴奋性增强，而阴极tDCS的后效则不那么明显。结论小鼠M1-tDCS模型可以实现与人体实验相似的tDCS对皮质兴奋性的调节作用。然而，与在人类中的应用相比，需要适当调整tDCS参数才能获得这些转化效应，因为在本研究中需要更高密度的电流才能获得与在人类中获得的效果相当的效果。

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引用次数: 0

Reducing artifacts during human intracranial electrical stimulation by separating current return from recording ground 通过从记录地分离电流返回来减少人颅内电刺激时的伪影。

IF 8.4 1区医学 Q1 CLINICAL NEUROLOGY

Brain Stimulation

Pub Date : 2025-11-01 DOI: 10.1016/j.brs.2025.10.017

Denise Oswalt, Michael S. Beauchamp, Han-Chiao Isaac Chen, Daniel Yoshor

引用次数: 0

Longitudinal evaluation of laryngeal motor-evoked potentials following vagus nerve stimulation in patients with drug-refractory epilepsy 药物难治性癫痫患者迷走神经刺激后喉运动诱发电位的纵向评价。

IF 8.4 1区医学 Q1 CLINICAL NEUROLOGY

Brain Stimulation

Pub Date : 2025-11-01 DOI: 10.1016/j.brs.2025.10.014

Venethia Danthine , Enrique Ignacio Germany Morrison , Inci Cakiroglu , Najoua Boughaba , Jean Delbeke , Antoine Nonclercq , Riëm El Tahry

引用次数: 0

Dual-target theta burst rTMS for the treatment of methamphetamine use disorder: An open-label pilot clinical trial 双靶点θ波爆发rTMS治疗甲基苯丙胺使用障碍：一项开放标签的试点临床试验

IF 8.4 1区医学 Q1 CLINICAL NEUROLOGY

Brain Stimulation

Pub Date : 2025-10-23 DOI: 10.1016/j.brs.2025.10.011

Jackson R. Richards , Benjamin D. Pace , Alison C. Lynch , Andrea N. Weber , Joel E. Bruss , Jatin G. Vaidya , Rana Jawish , Keith G. Jones , Brian J. Mickey , Ryan M. Carnahan , Nicholas T. Trapp

引用次数: 0

Corrigendum to “Decoding auditory working memory content from EEG responses to auditory-cortical TMS” [Brain Stimulation 18 3 (2025) 649–658] “从脑电图对听觉皮层TMS的反应中解码听觉工作记忆内容”的勘误表[脑刺激18(2025)649-658]。

IF 8.4 1区医学 Q1 CLINICAL NEUROLOGY

Brain Stimulation

Pub Date : 2025-10-17 DOI: 10.1016/j.brs.2025.10.009

Işıl Uluç , Mohammad Daneshzand , Mainak Jas , Parker Kotlarz , Kaisu Lankinen , Jennifer L. Fiedler , Fahimeh Mamashli , Netri Pajankar , Tori Turpin , Lucia Navarro de Lara , Padmavathi Sundaram , Tommi Raij , Aapo Nummenmaa , Jyrki Ahveninen

引用次数: 0

Asymmetric modular pulse synthesizer as a high-fidelity solution for transcranial magnetic stimulation with practically any pulse shape 不对称模块脉冲合成器作为一个高保真的解决方案，经颅磁刺激与几乎任何脉冲形状。

IF 8.4 1区医学 Q1 CLINICAL NEUROLOGY

Brain Stimulation

Pub Date : 2025-10-13 DOI: 10.1016/j.brs.2025.10.010

Jinshui Zhang, Angel V. Peterchev, Stefan M. Goetz

引用次数: 0

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