Brain Stimulation最新文献_第8页

Approximating signal sources in stereo-EEG single pulse electrical stimulation using re-referencing and spectral analysis 用重参考和频谱分析逼近立体脑电单脉冲电刺激的信号源。

IF 8.4 1区医学 Q1 CLINICAL NEUROLOGY

Brain Stimulation

Pub Date : 2025-11-01 DOI: 10.1016/j.brs.2025.10.015

Michael A. Jensen , Harvey Huang , Nicholas M. Gregg , Klaus-Robert Müller , Dora Hermes , Kai J. Miller

引用次数: 0

Anodal M1 tDCS shapes frequency-specific functional connectivity and network topology in Parkinson's disease 阳极M1 tDCS在帕金森病中形成频率特异性功能连接和网络拓扑。

IF 8.4 1区医学 Q1 CLINICAL NEUROLOGY

Brain Stimulation

Pub Date : 2025-11-01 DOI: 10.1016/j.brs.2025.10.016

Clara Simonetta , Matteo Conti , Jacopo Bissacco , Valerio Ferrari , Chiara Salimei , Federico Carparelli , Silvio Bagetta , Davide Mascioli , Veronica Buttarazzi , Maria Mancini , Francesca Di Giuliano , Nicola Biagio Mercuri , Mariangela Pierantozzi , Alessandro Stefani , Tommaso Schirinzi

Background

Transcranial direct current stimulation (tDCS) is a promising non-invasive intervention for Parkinson's disease (PD), but its mechanisms of action remain unclear. Understanding its network-level effects may support its use as an adjunctive therapeutic option, particularly in intermediate-stage PD when symptoms begin to escape pharmacological control.

Objective

To evaluate the clinical efficacy and functional connectivity (FC) changes of anodal tDCS over the primary motor cortex (M1) in patients with intermediate-stage PD.

Methods

Twenty-five patients underwent a randomized, double-blind, sham-controlled, crossover protocol, receiving anodal and sham M1-tDCS. Clinical assessments were measured before and after each intervention, alongside high-density EEG (HD-EEG) recordings in the OFF-medication state. Band-specific FC was analyzed using network-based statistics (NBS), and network topology was examined through graph-theoretical measures. Thirty age-matched healthy controls were included for baseline comparisons.

Results

anodal tDCS significantly reduced motor symptoms in the OFF-state, especially bradykinesia, tremor, and gait. It also improved non-motor symptoms and cognitive performance. HD-EEG FC analyses revealed increased α-band FC and decreased pathological β-band hyperconnectivity, both correlating with clinical improvements. Notably, graph analyses showed reduced scale-free organization in both α- and β-band networks post-tDCS, likely reflecting the widespread and non-selective stimulation of multiple nodes. Sham stimulation induced no significant changes.

Conclusions

Therapeutic effects of anodal M1-tDCS appear to be mediated by frequency-specific modulation of cortical networks, enhancing α-band synchronization and reducing β-band hypersynchrony, alongside a topological reconfiguration of brain architecture. These network-level effects strengthen the rationale for using tDCS in PD, particularly as a potential therapeutic option in the intermediate stage.

背景：经颅直流电刺激（tDCS）是治疗帕金森病（PD）的一种很有前景的非侵入性干预手段，但其作用机制尚不清楚。了解其网络水平的作用可能支持其作为辅助治疗选择的使用，特别是在症状开始脱离药物控制的中期PD。目的：评价中期PD患者原发性运动皮质（M1）阳极tDCS的临床疗效及功能连通性（FC）变化。方法：25例患者采用随机、双盲、假对照、交叉方案，分别接受假M1-tDCS和假M1-tDCS治疗。在每次干预前后测量临床评估，并在off - drug状态下测量高密度脑电图（HD-EEG）记录。使用基于网络的统计（NBS）分析了特定频带的FC，并通过图理论测量检查了网络拓扑。30名年龄匹配的健康对照纳入基线比较。结果：阳极tDCS显著减轻了off状态下的运动症状，尤其是运动迟缓、震颤和步态。它还改善了非运动症状和认知表现。HD-EEG FC分析显示α带FC增加，病理性β带超连通性降低，两者均与临床改善相关。值得注意的是，图分析显示，tdcs后α-和β波段网络的无标度组织减少，可能反映了多个节点的广泛和非选择性刺激。假性刺激未引起明显变化。结论：阳极M1-tDCS的治疗效果似乎是由皮质网络的频率特异性调节介导的，增强α-带同步，减少β-带超同步，以及大脑结构的拓扑重构。这些网络层面的效应加强了在PD中使用tDCS的理论依据，特别是在中间阶段作为潜在的治疗选择。

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引用次数: 0

Hippocampal-network transcranial magnetic stimulation to target reactivated intrusive memories: A proof-of-concept study in PTSD treatment 海马体-网络经颅磁刺激靶重新激活侵入性记忆：PTSD治疗的概念验证研究。

IF 8.4 1区医学 Q1 CLINICAL NEUROLOGY

Brain Stimulation

Pub Date : 2025-11-01 DOI: 10.1016/j.brs.2025.10.019

Or Dezachyo , Noga Yair , Noga Mendelovich , Niv Tik , Daniel S. Pine , Haggai Sharon , Ido Tavor , Yair Bar-Haim , Nitzan Censor

引用次数: 0

Brain injury during focused ultrasound neuromodulation for substance use disorder 聚焦超声神经调节对物质使用障碍的脑损伤。

IF 8.4 1区医学 Q1 CLINICAL NEUROLOGY

Brain Stimulation

Pub Date : 2025-11-01 DOI: 10.1016/j.brs.2025.10.012

Ali Rezai, Manish Ranjan, Aniruddha Bhagwat, Tasneem Arsiwala, Jeffrey Carpenter, Mark Schafer, Geoffrey Adams, Jennifer Marton, Padmashree Tirumalai, Daniel Farmer, James Mahoney, Victor Finomore

引用次数: 0

Evidence for safety and tolerability of transcranial magnetic stimulation for substance use disorders 经颅磁刺激治疗物质使用障碍的安全性和耐受性证据。

IF 8.4 1区医学 Q1 CLINICAL NEUROLOGY

Brain Stimulation

Pub Date : 2025-11-01 DOI: 10.1016/j.brs.2025.11.002

Sophia H. Blyth , Rabee Haq , Sahit Menon , Benson King , Gabriela Torres Quesada , Darara Borodge , Benjamin Johnson , J. Mason Harding , Simon Vandekar , Heather Burrell Ward

Objective

Transcranial magnetic stimulation (TMS) is an exciting novel treatment for substance use disorders (SUDs). While TMS is safe and effective in the general population, there have been concerns about its safety with concurrent substance use. To date, guidelines on managing substance use during TMS have been vague – recommending caution and weighing risks and benefits – and solely based on expert opinion, rather than based on quantitative data on the prevalence of TMS side effects with concurrent substance use.

Methods

We performed a systematic review with meta-analysis of TMS studies for a SUD – a clinically impairing level of substance use where we would be more likely to detect adverse effects – to quantify the safety of TMS in the setting of substance use. We searched PubMed, Embase, PsycINFO, and the Cochrane Library for TMS studies for SUDs that reported adverse effects. We extracted adverse effects and tested the difference between the prevalence of events in the active and sham conditions.

Results

Forty-seven studies comprising 2865 participants with a SUD were included. The prevalence of neck pain and cognitive impairment was higher for sham compared to active TMS (p < .05). The prevalence of all other adverse effects, including seizure, was not significantly different between active and sham TMS.

Conclusions

TMS is safe and well-tolerated for people with SUDs. The prevalence of side effects from TMS in people with SUDs is comparable to that in the general population. TMS can be just as safely administered for SUDs as for any other psychiatric disorder.

目的：经颅磁刺激（TMS）是一种令人兴奋的治疗物质使用障碍（sud）的新方法。虽然经颅磁刺激在一般人群中是安全有效的，但人们一直担心同时使用药物的安全性。迄今为止，关于经颅磁刺激期间药物使用管理的指导方针一直很模糊——建议谨慎，权衡风险和收益——并且完全基于专家意见，而不是基于同时使用药物的经颅磁刺激副作用发生率的定量数据。方法：我们对经颅磁刺激对SUD的研究进行了系统回顾和荟萃分析，以量化经颅磁刺激在药物使用背景下的安全性。SUD是一种临床损害水平的药物使用，我们更有可能发现不良反应。我们检索了PubMed、Embase、PsycINFO和Cochrane图书馆中报道有不良反应的经颅磁刺激研究。我们提取了不良反应，并测试了活动和假手术条件下事件发生率的差异。结果：纳入47项研究，包括2,865名患有SUD的参与者。与主动经颅磁刺激相比，假手术组颈部疼痛和认知障碍的患病率更高(结论：经颅磁刺激对sud患者是安全且耐受性良好的。经颅磁刺激在sud患者中的副作用发生率与一般人群相当。经颅磁刺激可以像治疗其他精神疾病一样安全地应用于sud。

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引用次数: 0

Human applications of transcranial temporal interference stimulation: A systematic review 经颅颞叶干扰刺激的人体应用：系统综述。

IF 8.4 1区医学 Q1 CLINICAL NEUROLOGY

Brain Stimulation

Pub Date : 2025-11-01 DOI: 10.1016/j.brs.2025.10.023

Ilya Demchenko , Ishaan Tailor , Sina Chegini , Haochen Yu , Fatemeh Gholamali Nezhad , Alice Rueda , Anne Kever , Sridhar Krishnan , Abhishek Datta , Jed A. Meltzer , Simon J. Graham , Tom A. Schweizer , Sumientra Rampersad , Edward S. Boyden , Ines R. Violante , Robert Chen , Andres M. Lozano , Venkat Bhat

Background

Many neurological and psychiatric disorders involve dysregulation of subcortical structures. Transcranial temporal interference stimulation (tTIS) is a novel, non-invasive method developed to selectively modulate deep brain regions and associated neural circuits.

Methods

A systematic review was conducted to evaluate human applications of tTIS (PROSPERO ID: CRD42024559678). MEDLINE, Embase, APA PsycINFO, CENTRAL, ClinicalTrials.gov, and WHO ICTRP were searched up to December 12, 2024. Studies involving human applications of tTIS were eligible. Methodological quality was appraised using the National Institutes of Health and modified Oxford Centre for Evidence-Based Medicine tools.

Results

Forty-eight records were reviewed (20 published studies, 28 ongoing trials). Of published studies, 16 single-session and 4 multi-session studies assessed safety, mechanistic outcomes, or therapeutic effects of tTIS in 820 participants. Stimulation was most commonly delivered at beta (20 Hz) or gamma (30–130 Hz) envelope frequencies. Neuroimaging studies support target engagement of the motor cortex, basal ganglia, and hippocampus in humans, particularly when stimulation is paired with behavioural tasks. Preliminary clinical findings in small samples demonstrated acute symptom improvements in bradykinesia and tremor within 60 min following a single tTIS session in Parkinson's disease and essential tremor. Reported adverse events across studies were mild (e.g., tingling, itching). Emerging trials increasingly utilize multi-session protocols (2–40 sessions) and are extending tTIS to patients with neurological and psychiatric disorders, particularly epilepsy and depression.

Conclusions

Phase 1 studies demonstrate that tTIS is safe, well-tolerated, and capable of engaging deep brain targets in humans. Well-controlled Phase 2 trials are needed to assess its therapeutic potential in patient populations.

背景：许多神经和精神疾病涉及皮质下结构的失调。经颅颞叶干扰刺激（tTIS）是一种新的、非侵入性的方法，可以选择性地调节脑深部区域和相关的神经回路。方法：对tTIS （PROSPERO ID: CRD42024559678）的临床应用进行系统评价。MEDLINE, Embase, APA PsycINFO， CENTRAL, ClinicalTrials.gov和WHO ICTRP被检索到2024年12月12日。涉及tTIS人体应用的研究是合格的。采用美国国立卫生研究院和改良的牛津循证医学中心工具对方法学质量进行评价。结果：回顾了48项记录（20项已发表的研究，28项正在进行的试验）。在已发表的研究中，有16项单期研究和4项多期研究评估了820名参与者的tTIS的安全性、机制结局或治疗效果。刺激最常见的是在β（20赫兹）或γ（30-130赫兹）包络频率下进行。神经影像学研究支持人类运动皮层、基底神经节和海马体的目标参与，特别是当刺激与行为任务配对时。在小样本中的初步临床结果显示，帕金森病和原发性震颤患者在单次tTIS治疗后60分钟内，运动迟缓和震颤的急性症状得到改善。所有研究报告的不良事件都是轻微的（例如，刺痛，瘙痒）。新兴试验越来越多地采用多期治疗方案（2-40期），并将tTIS扩展到神经和精神疾病患者，特别是癫痫和抑郁症患者。结论：i期研究表明，tTIS是安全的，耐受性良好，并且能够作用于人类深部脑靶点。需要进行控制良好的2期试验来评估其在患者群体中的治疗潜力。

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引用次数: 0

Effects of cue-synchronized parietal cathodal tDCS on internet gaming disorder: A randomized double-blind sham-controlled trial 线索同步顶叶阴极tDCS对网络游戏障碍的影响：一项随机双盲假对照试验。

IF 8.4 1区医学 Q1 CLINICAL NEUROLOGY

Brain Stimulation

Pub Date : 2025-11-01 DOI: 10.1016/j.brs.2025.10.025

Yixuan Song , Yuchen Huang , Qihong Zheng , Xiaoqin Yang , Yang Guo , Yanan Geng , Huixing Gou , Junjie Bu , Tianye Jia , Guangdong Zhou , Lin Lu , Jie Shi , Yan Sun

Background and objectives

Internet Gaming Disorder (IGD) is prevalent with limited treatment efficacy. Targeting reducing craving triggered by gaming cues is a critical therapeutic objective. This study aimed to establish optimized electroencephalography (EEG) biomarkers for IGD and develop a novel targeted neuromodulation protocol.

Methods

In the exploratory study, the optimized EEG indicators of IGD diagnose were identified through machine learning models based on event-related potential (ERP) and band power during game cue exposure across two independent datasets (Dataset 1: twenty-five IGD, twenty-two Recreational Game Users, twenty-eight non-gaming Healthy Controls (HC); Dataset 2: twenty-three IGD and twenty-three HC). Subsequently, in the intervention study, a double-blind randomized trial was conducted on forty-six IGD participants to compare active and sham transcranial direct current stimulation (tDCS) targeting the region where the optimized EEG marker was located—central parietal lobe (Pz). Active stimulation (1.5 mA, 20 min, 2 days) was applied during cue exposure (cathode: Pz; anode: right trapezius).

Results

Parieto-occipital P300 (peaked at Pz, IGD > HC) during game reactivity emerged as novel optimized EEG indicators for IGD discrimination (accuracy>80 %), linked to craving. Then, Pz targeted cathodal tDCS synchronized with game cue exposure could significantly reduce craving (p < 0.001), gaming time (p < 0.001), and P300 alpha (p = 0.048) after intervention and at 1–4 weeks follow-ups, with concomitant improvement of decision-making in the active group. Importantly, these effects generalized to unpresented gaming cues. Besides, we identified baseline delta power at Pz during gaming cues as a significant predictor for treatment effects.

Conclusion

Our findings establish cue-synchronized tDCS as an effective intervention approach and position the Pz as a novel therapeutic target for IGD neuromodulation.

背景和目的：网络游戏障碍（IGD）普遍存在，但治疗效果有限。以减少由游戏线索引发的渴望为目标是一个关键的治疗目标。本研究旨在建立优化的IGD脑电图（EEG）生物标志物，并开发一种新的靶向神经调节方案。方法：在探索性研究中，通过基于事件相关电位（ERP）和游戏线索暴露时频带功率的机器学习模型，确定了两个独立数据集(数据集1:25名IGD， 22名休闲游戏用户，28名非游戏健康对照组；数据集2:23个IGD和23个HC)。随后，在干预研究中，对46名IGD参与者进行了双盲随机试验，比较针对优化EEG标记所在区域-中央顶叶（Pz）的主动和假性经颅直流电刺激（tDCS）。在提示暴露期间，施加主动刺激（1.5 mA， 20分钟，2天）（阴极：Pz；阳极：右斜方肌）。结果：在游戏反应期间，顶枕P300（峰值在Pz， IGD>HC）成为与渴望相关的IGD辨别（准确率>80%）的新的优化EEG指标。结论：我们的研究结果证实了线索同步tDCS是一种有效的干预方法，并将Pz定位为IGD神经调节的一种新的治疗靶点。

{"title":"Effects of cue-synchronized parietal cathodal tDCS on internet gaming disorder: A randomized double-blind sham-controlled trial","authors":"Yixuan Song , Yuchen Huang , Qihong Zheng , Xiaoqin Yang , Yang Guo , Yanan Geng , Huixing Gou , Junjie Bu , Tianye Jia , Guangdong Zhou , Lin Lu , Jie Shi , Yan Sun","doi":"10.1016/j.brs.2025.10.025","DOIUrl":"10.1016/j.brs.2025.10.025","url":null,"abstract":"<div><h3>Background and objectives</h3><div>Internet Gaming Disorder (IGD) is prevalent with limited treatment efficacy. Targeting reducing craving triggered by gaming cues is a critical therapeutic objective. This study aimed to establish optimized electroencephalography (EEG) biomarkers for IGD and develop a novel targeted neuromodulation protocol.</div></div><div><h3>Methods</h3><div>In the exploratory study, the optimized EEG indicators of IGD diagnose were identified through machine learning models based on event-related potential (ERP) and band power during game cue exposure across two independent datasets (Dataset 1: twenty-five IGD, twenty-two Recreational Game Users, twenty-eight non-gaming Healthy Controls (HC); Dataset 2: twenty-three IGD and twenty-three HC). Subsequently, in the intervention study, a double-blind randomized trial was conducted on forty-six IGD participants to compare active and sham transcranial direct current stimulation (tDCS) targeting the region where the optimized EEG marker was located—central parietal lobe (Pz). Active stimulation (1.5 mA, 20 min, 2 days) was applied during cue exposure (cathode: Pz; anode: right trapezius).</div></div><div><h3>Results</h3><div>Parieto-occipital P300 (peaked at Pz, IGD > HC) during game reactivity emerged as novel optimized EEG indicators for IGD discrimination (accuracy>80 %), linked to craving. Then, Pz targeted cathodal tDCS synchronized with game cue exposure could significantly reduce craving (<em>p</em> < 0.001), gaming time (<em>p</em> < 0.001), and P300 alpha (<em>p</em> = 0.048) after intervention and at 1–4 weeks follow-ups, with concomitant improvement of decision-making in the active group. Importantly, these effects generalized to unpresented gaming cues. Besides, we identified baseline delta power at Pz during gaming cues as a significant predictor for treatment effects.</div></div><div><h3>Conclusion</h3><div>Our findings establish cue-synchronized tDCS as an effective intervention approach and position the Pz as a novel therapeutic target for IGD neuromodulation.</div></div>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 6","pages":"Pages 2016-2027"},"PeriodicalIF":8.4,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145426492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of DBS computational modeling methodologies using in-vivo electrophysiology in Parkinson's disease 帕金森病患者体内电生理DBS计算建模方法的评估。

IF 8.4 1区医学 Q1 CLINICAL NEUROLOGY

Brain Stimulation

Pub Date : 2025-11-01 DOI: 10.1016/j.brs.2025.10.022

Seyyed Bahram Borgheai , Bryan Howell , Faical Isbaine , Angela M. Noecker , Enrico Opri , Benjamin B. Risk , Cameron C. McIntyre , Svjetlana Miocinovic

Background

Optimizing deep brain stimulation (DBS) parameter settings requires postoperative adjustments through a time-consuming trial-and-error process. As such, researchers have been developing computational models to guide DBS programming. Despite growing interest in image-guided DBS technology, and recent adoption into clinical practice, the direct validation of the prediction accuracy remains limited.

Objective

The objective of this study was to establish a comparative framework for validating the accuracy of various DBS computational modeling methodologies in predicting the activation of clinically relevant pathways using in vivo measurements from PD patients undergoing subthalamic (STN) DBS surgery.

Methods

In this study, we compared the accuracy of six computational modeling variations for predicting the activation of the corticospinal/bulbar tract (CSBT) and cortico-subthalamic hyperdirect pathway (HDP) using very short- (<2 ms) and short-latency (2–4 ms) cortical evoked potentials (cEPs). We constructed the variations using three key factors: modeling method (Driving Force [DF] vs. Volume of Tissue Activated [VTA]), imaging space (native vs. normative), and anatomical representation (pathway vs. structure). The model performances were quantified using the coefficient of determination (R²) between the cEP amplitudes and percent pathway or structure activation.

Results

We compared model accuracy for 11 PD patients. The DF-Native-Pathway model was the most accurate method for quantitatively predicting experimental subcortical pathway activations. Additionally, our analysis showed that using normative brain space significantly diminished the accuracy of model predictions.

Conclusion

The choice of methodology should depend on the specific application and the required level of precision for the intended analysis. However, model parameters should be optimized to accurately predict known experimental activation measures.

背景：优化脑深部刺激（DBS）的参数设置需要通过一个耗时的反复试验过程进行术后调整。因此，研究人员一直在开发计算模型来指导DBS编程。尽管人们对图像引导的DBS技术越来越感兴趣，并且最近应用于临床实践，但对预测准确性的直接验证仍然有限。目的：本研究的目的是建立一个比较框架，以验证各种DBS计算建模方法在预测临床相关通路激活方面的准确性，这些方法使用的是接受下丘脑（STN） DBS手术的PD患者的体内测量。方法：在这项研究中，我们比较了六种计算模型的准确性，用于预测皮质脊髓/球束（CSBT）和皮质-丘脑下超直接通路（HDP）的激活，使用cEP振幅和百分比通路或结构激活之间的极短间隔(2)。结果：我们比较了11例PD患者的模型准确性。DF-Native-Pathway模型是定量预测实验皮层下通路激活最准确的方法。此外，我们的分析表明，使用规范的大脑空间显著降低了模型预测的准确性。结论：方法学的选择应取决于具体应用和预期分析所需的精度水平。然而，为了准确预测已知的实验激活措施，需要对模型参数进行优化。

{"title":"Evaluation of DBS computational modeling methodologies using in-vivo electrophysiology in Parkinson's disease","authors":"Seyyed Bahram Borgheai , Bryan Howell , Faical Isbaine , Angela M. Noecker , Enrico Opri , Benjamin B. Risk , Cameron C. McIntyre , Svjetlana Miocinovic","doi":"10.1016/j.brs.2025.10.022","DOIUrl":"10.1016/j.brs.2025.10.022","url":null,"abstract":"<div><h3>Background</h3><div>Optimizing deep brain stimulation (DBS) parameter settings requires postoperative adjustments through a time-consuming trial-and-error process. As such, researchers have been developing computational models to guide DBS programming. Despite growing interest in image-guided DBS technology, and recent adoption into clinical practice, the direct validation of the prediction accuracy remains limited.</div></div><div><h3>Objective</h3><div>The objective of this study was to establish a comparative framework for validating the accuracy of various DBS computational modeling methodologies in predicting the activation of clinically relevant pathways using in vivo measurements from PD patients undergoing subthalamic (STN) DBS surgery.</div></div><div><h3>Methods</h3><div>In this study, we compared the accuracy of six computational modeling variations for predicting the activation of the corticospinal/bulbar tract (CSBT) and cortico-subthalamic hyperdirect pathway (HDP) using very short- (<2 ms) and short-latency (2–4 ms) cortical evoked potentials (cEPs). We constructed the variations using three key factors: modeling method (Driving Force [DF] vs. Volume of Tissue Activated [VTA]), imaging space (native vs. normative), and anatomical representation (pathway vs. structure). The model performances were quantified using the coefficient of determination (R<sup>2</sup>) between the cEP amplitudes and percent pathway or structure activation.</div></div><div><h3>Results</h3><div>We compared model accuracy for 11 PD patients. The DF-Native-Pathway model was the most accurate method for quantitatively predicting experimental subcortical pathway activations. Additionally, our analysis showed that using normative brain space significantly diminished the accuracy of model predictions.</div></div><div><h3>Conclusion</h3><div>The choice of methodology should depend on the specific application and the required level of precision for the intended analysis. However, model parameters should be optimized to accurately predict known experimental activation measures.</div></div>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 6","pages":"Pages 1996-2007"},"PeriodicalIF":8.4,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145399944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Letter to the Editor in response to “Brain injury during focused ultrasound neuromodulation for substance use disorder” 致编辑的回应“聚焦超声神经调节治疗物质使用障碍期间的脑损伤”的信。

IF 8.4 1区医学 Q1 CLINICAL NEUROLOGY

Brain Stimulation

Pub Date : 2025-11-01 DOI: 10.1016/j.brs.2025.11.004

Kim Butts Pauly

引用次数: 0

TMS-induced modulation of brain networks and its associations to rTMS treatment for depression: a concurrent fMRI-EEG-TMS study 经颅磁刺激诱导的脑网络调节及其与经颅磁刺激治疗抑郁症的关联：fMRI-EEG-TMS同步研究。

IF 8.4 1区医学 Q1 CLINICAL NEUROLOGY

Brain Stimulation

Pub Date : 2025-11-01 DOI: 10.1016/j.brs.2025.10.013

Hengda He , Xiaoxiao Sun , Jayce Doose , Josef Faller , James R. McIntosh , Golbarg T. Saber , Sarah Huffman , Linbi Hong , Spiro P. Pantazatos , Han Yuan , Lisa M. McTeague , Robin I. Goldman , Truman R. Brown , Mark S. George , Paul Sajda

Introduction

Transcranial magnetic stimulation (TMS) over the left dorsolateral prefrontal cortex (L-DLPFC) is an established intervention for treatment-resistant depression (TRD), yet the underlying therapeutic mechanisms remain not fully understood.

Methods

This study employs an integrative approach that combines TMS with concurrent functional magnetic resonance imaging (fMRI) and electroencephalography (EEG), aimed at assessing the acute/immediate effects of TMS on brain network dynamics and their correlation with clinical outcomes. Furthermore, this study explored the brain-state dependent effects of TMS, as the brain-state indexed by the phase of EEG prefrontal alpha oscillation.

Results

Our study demonstrates that TMS acutely modulates connectivity within vital brain circuits, particularly the cognitive control and default mode networks. We found that the baseline TMS-evoked responses in the cognitive control and limbic networks significantly predicted clinical improvement in patients receiving a novel EEG-synchronized repetitive TMS treatment. Clinical outcomes in this novel treatment were linked to state-specific TMS-modulated functional connectivity within a pivotal brain circuit of the L-DLPFC and the posterior subgenual anterior cingulate cortex within the limbic system.

Conclusions

These findings contribute to our understanding of the therapeutic effects underlying TMS treatment in depression and support the potential of assessing state-dependent TMS effects. This study emphasizes the importance of personalized timing of TMS for optimizing target engagement of specific clinically relevant brain circuits. Our results are crucial for future research into the development of personalized neuromodulation therapies for TRD patients.

导读：经颅磁刺激（TMS）在左背外侧前额叶皮层（L-DLPFC）是一种确定的治疗难治性抑郁症（TRD）的干预措施，但其潜在的治疗机制尚不完全清楚。方法：本研究采用经颅磁刺激与并发功能磁共振成像（fMRI）和脑电图（EEG）相结合的综合方法，旨在评估经颅磁刺激对脑网络动力学的急性/即时影响及其与临床结果的相关性。此外，本研究还探讨了经颅磁刺激的脑状态依赖效应，即通过脑电图前额叶α振荡的相位来指示脑状态。结果：我们的研究表明，经颅磁刺激可以显著调节重要脑回路的连通性，特别是认知控制和默认模式网络。我们发现，认知控制和边缘网络的基线TMS诱发反应显著预测了接受脑电图同步重复TMS治疗的患者的临床改善。我们发现，这种新疗法的临床结果与大脑边缘系统中L-DLPFC和后亚属前扣带皮层的关键脑回路中特定状态的tms调节的功能连接有关。结论：这些发现有助于我们理解经颅磁刺激治疗抑郁症的治疗效果，并支持评估状态依赖性经颅磁刺激效果的潜力。本研究强调了个性化的经颅磁刺激时间对于优化特定临床相关脑回路的目标参与的重要性。我们的结果对未来TRD患者个性化神经调节疗法的发展研究至关重要。

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引用次数: 0