Pub Date : 2023-01-01DOI: 10.24070/bjvp.1983-0246.v16i2p144-147
Clarissa Helena Santana, Ayisa Rodrigues Oliveira, Lucas dos Reis de Souza, Thaynara Parente de Carvalho, Fernanda Mara Aragão Macedo Pereira, Laice Alves da Silva, Samantha Pinheiro Pimentel, Daniel Oliveira dos Santos, Lauro Leite Soares-, Andressa Quinalia Courbilly, Jéssica Magalhães da Silva, Tatiane Alves da Paixão, Renato Lima Santos
Lafora’s disease is a genetic disease associated to mutations in genes that encodes laforin and malin, which results in intracellular polyglucan storage. The present report describes a case of Lafora’s disease in a toco toucan with episodes of incoordination and myoclonus that resulted in traumatic lesions and fracture of the left hindlimb. The bird was euthanized and submitted to necropsy. Microscopically there were abundant PAS-positive and diastasis-resistant Lafora’s inclusion bodies in neurons in the cerebellum, supporting the diagnosis of Lafora’s disease.
{"title":"Lafora’s disease in a free-ranging toco toucan (Ramphastos toco) with neurologic disease","authors":"Clarissa Helena Santana, Ayisa Rodrigues Oliveira, Lucas dos Reis de Souza, Thaynara Parente de Carvalho, Fernanda Mara Aragão Macedo Pereira, Laice Alves da Silva, Samantha Pinheiro Pimentel, Daniel Oliveira dos Santos, Lauro Leite Soares-, Andressa Quinalia Courbilly, Jéssica Magalhães da Silva, Tatiane Alves da Paixão, Renato Lima Santos","doi":"10.24070/bjvp.1983-0246.v16i2p144-147","DOIUrl":"https://doi.org/10.24070/bjvp.1983-0246.v16i2p144-147","url":null,"abstract":"Lafora’s disease is a genetic disease associated to mutations in genes that encodes laforin and malin, which results in intracellular polyglucan storage. The present report describes a case of Lafora’s disease in a toco toucan with episodes of incoordination and myoclonus that resulted in traumatic lesions and fracture of the left hindlimb. The bird was euthanized and submitted to necropsy. Microscopically there were abundant PAS-positive and diastasis-resistant Lafora’s inclusion bodies in neurons in the cerebellum, supporting the diagnosis of Lafora’s disease.","PeriodicalId":9223,"journal":{"name":"Brazilian Journal of Veterinary Pathology","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135442387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.24070/bjvp.1983-0246.v16i2p112-116
Fabíola Cardoso Vieira, Ives Feitosa Duarte, Uila Silveira de Medeiros, Guilherme Albuquerque de Oliveira Cavalcanti, Jéssica Line Farias de Lima, Silvia Regina Legal Ladeira, Mauro Pereira Soares, Amanda Andersson Pereira Stark, Raqueli Teresinha França
The purpose of this manuscript is to describe the clinical-pathological aspects of cardiac hypertrophy related to the presence of Corynebacterium spp. in three Didelphis albiventris cubs. In necropsy, macroscopically, in the heart, cardiomegaly, concentric hypertrophy of the ventricles and the ventricular septum were observed, with consequent reduction of the chamber. Microscopically, the primary lesions found in the heart were cardiomyocyte hypertrophy and necrosis, myocytolysis, and the presence of myriad basophilic bacteria. Liver fragments and endocardial swabs were sent for bacterial culture, in which pleomorphic Gram-positive rods grew, forming small and hemolytic colonies. Chemical tests demonstrated characteristics compatible with Corynebacterium spp. Thus, this report represents the first description of cardiac hypertrophy associated with Corynebacterium spp. in white-eared opossums cubs, representing an essential contribution to studying diseases in wild animals.
{"title":"Cardiac hypertrophy associated with Corynebacterium spp. in Didelphis albiventris cubs","authors":"Fabíola Cardoso Vieira, Ives Feitosa Duarte, Uila Silveira de Medeiros, Guilherme Albuquerque de Oliveira Cavalcanti, Jéssica Line Farias de Lima, Silvia Regina Legal Ladeira, Mauro Pereira Soares, Amanda Andersson Pereira Stark, Raqueli Teresinha França","doi":"10.24070/bjvp.1983-0246.v16i2p112-116","DOIUrl":"https://doi.org/10.24070/bjvp.1983-0246.v16i2p112-116","url":null,"abstract":"The purpose of this manuscript is to describe the clinical-pathological aspects of cardiac hypertrophy related to the presence of Corynebacterium spp. in three Didelphis albiventris cubs. In necropsy, macroscopically, in the heart, cardiomegaly, concentric hypertrophy of the ventricles and the ventricular septum were observed, with consequent reduction of the chamber. Microscopically, the primary lesions found in the heart were cardiomyocyte hypertrophy and necrosis, myocytolysis, and the presence of myriad basophilic bacteria. Liver fragments and endocardial swabs were sent for bacterial culture, in which pleomorphic Gram-positive rods grew, forming small and hemolytic colonies. Chemical tests demonstrated characteristics compatible with Corynebacterium spp. Thus, this report represents the first description of cardiac hypertrophy associated with Corynebacterium spp. in white-eared opossums cubs, representing an essential contribution to studying diseases in wild animals.","PeriodicalId":9223,"journal":{"name":"Brazilian Journal of Veterinary Pathology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135445794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.24070/bjvp.1983-0246.v16i3p188-191
Isabeli Joaquim Contel, Pedro Pol Ximenes, Fernando Carmona Dinau, Fernanda Barthelson Carvalho de Moura, Giovanna Gati de Souza, Iolanda Simões Braga, Isadora Fernanda Pelaquim, Rafael Torres, Noeme Sousa Rocha
Canine insulinoma is a common non-specific neoplasm with high metastasizing ability. Its epidemiology, diagnosis, and treatment are well described. However, its long-term prognosis is considered poor. We report a rare case of insulinoma in a small-size, mixed-breed adult dog, which presented with a circling walk, seizures, weakness, depressed mental state, and hypoglycemia. Glucose continuous rate infusion, diazepam, and phenobarbital were initiated to stabilize the glycemia and control the convulsion. Blood tests, fine needle aspiration cytology, ultrasound and radiological tests, and histology and immunohistochemical analysis confirmed the diagnosis of insulinoma, emphasizing the relevance of considering it as a differential diagnosis for small canine breeds and younger animals. Further, dogs can be regarded as an experimental animal model for human insulinoma research as they share characteristics.
{"title":"Clinicopathological and immunohistochemical features of insulinoma in an adult mixed breed dog","authors":"Isabeli Joaquim Contel, Pedro Pol Ximenes, Fernando Carmona Dinau, Fernanda Barthelson Carvalho de Moura, Giovanna Gati de Souza, Iolanda Simões Braga, Isadora Fernanda Pelaquim, Rafael Torres, Noeme Sousa Rocha","doi":"10.24070/bjvp.1983-0246.v16i3p188-191","DOIUrl":"https://doi.org/10.24070/bjvp.1983-0246.v16i3p188-191","url":null,"abstract":"Canine insulinoma is a common non-specific neoplasm with high metastasizing ability. Its epidemiology, diagnosis, and treatment are well described. However, its long-term prognosis is considered poor. We report a rare case of insulinoma in a small-size, mixed-breed adult dog, which presented with a circling walk, seizures, weakness, depressed mental state, and hypoglycemia. Glucose continuous rate infusion, diazepam, and phenobarbital were initiated to stabilize the glycemia and control the convulsion. Blood tests, fine needle aspiration cytology, ultrasound and radiological tests, and histology and immunohistochemical analysis confirmed the diagnosis of insulinoma, emphasizing the relevance of considering it as a differential diagnosis for small canine breeds and younger animals. Further, dogs can be regarded as an experimental animal model for human insulinoma research as they share characteristics.","PeriodicalId":9223,"journal":{"name":"Brazilian Journal of Veterinary Pathology","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135448212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.24070/bjvp.1983-0246.v16i3p159-166
Ronaldo José Piccoli, Leonardo Gruchouskei, André Luis Vriesman Beninca, Marina Maurente Béron, Arthur Colombari Cheng, Joice Aparecida de Andrade, Mayane Faccin, Aline Patrícia Grzegozevski, Geórgia Carolina Rohden da Silva, Jaqueline Coelho França, Nelson Luis Mello Fernandes, Anderson Luiz de Carvalho, Aline de Marco Viott
Chlamydiosis is a zoonotic disease that affects several animal species. Therefore, reliable detection techniques are essential for efficient control of the disease. Fluorescence in situ hybridization (FISH) for Chlamydia sp. was applied to 137 formalin-fixed, paraffin-embedded liver sections from native and exotic birds. The samples were divided into two groups: retrospective (n=57) and prospective (n=80). The probe was designed based on an annealing sequence that targets the Major Outer Membrane Protein coding gene. Livers previously confirmed for Chlamydia psittaci by polymerase chain reaction (PCR) and immunohistochemistry (IHC) were used as positive controls. Also, 47 randomly selected samples from the prospective group were submitted to PCR for Chlamydia psittaci for confirmation. From all 137 samples, 67% (92/137) were positive for Chlamydia sp. through FISH, from which 39% (36/57) and 61% (56/80) were from the retrospective and prospective groups, respectively. From the samples of the prospective group submitted for PCR confirmation, 83% (39/47) of them had a positive correlation with FISH results. When considering the number of targeted microorganisms per 400x field, 42,39% (39/92) of the samples had up to five microorganisms, 14,13% (13/92) had from six to ten, and 43,47% (40/92) of the samples had 11 or more microorganisms per field. FISH is a specific and reliable method to identify Chlamydia sp. in histologic sections of the liver, providing an additional tool for detecting avian chlamydiosis.
{"title":"Detection of Chlamydia sp. by fluorescence in situ hybridization (FISH) in histologic sections of the liver from exotic and native avian species","authors":"Ronaldo José Piccoli, Leonardo Gruchouskei, André Luis Vriesman Beninca, Marina Maurente Béron, Arthur Colombari Cheng, Joice Aparecida de Andrade, Mayane Faccin, Aline Patrícia Grzegozevski, Geórgia Carolina Rohden da Silva, Jaqueline Coelho França, Nelson Luis Mello Fernandes, Anderson Luiz de Carvalho, Aline de Marco Viott","doi":"10.24070/bjvp.1983-0246.v16i3p159-166","DOIUrl":"https://doi.org/10.24070/bjvp.1983-0246.v16i3p159-166","url":null,"abstract":"Chlamydiosis is a zoonotic disease that affects several animal species. Therefore, reliable detection techniques are essential for efficient control of the disease. Fluorescence in situ hybridization (FISH) for Chlamydia sp. was applied to 137 formalin-fixed, paraffin-embedded liver sections from native and exotic birds. The samples were divided into two groups: retrospective (n=57) and prospective (n=80). The probe was designed based on an annealing sequence that targets the Major Outer Membrane Protein coding gene. Livers previously confirmed for Chlamydia psittaci by polymerase chain reaction (PCR) and immunohistochemistry (IHC) were used as positive controls. Also, 47 randomly selected samples from the prospective group were submitted to PCR for Chlamydia psittaci for confirmation. From all 137 samples, 67% (92/137) were positive for Chlamydia sp. through FISH, from which 39% (36/57) and 61% (56/80) were from the retrospective and prospective groups, respectively. From the samples of the prospective group submitted for PCR confirmation, 83% (39/47) of them had a positive correlation with FISH results. When considering the number of targeted microorganisms per 400x field, 42,39% (39/92) of the samples had up to five microorganisms, 14,13% (13/92) had from six to ten, and 43,47% (40/92) of the samples had 11 or more microorganisms per field. FISH is a specific and reliable method to identify Chlamydia sp. in histologic sections of the liver, providing an additional tool for detecting avian chlamydiosis.","PeriodicalId":9223,"journal":{"name":"Brazilian Journal of Veterinary Pathology","volume":"365 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135448520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.24070/bjvp.1983-0246.v16i2p108-111
Rafael Rocha Mello Emboaba da Costa, Júlio Edward Hough Monteiro, Claudia de Souza Silva, Fernanda Ramalho Ramos, Bethânia Almeida Gouveia, Paulo Henrique Leal Bertolo, Rosemeri de Oliveira Vasconcelos
Gurltia paralysans is a nematode first described in 1933 in Chile, causing a syndrome called feline crural parasitic paraplegia. Insects, mollusks, frogs, lizards, and rodents are paratenic hosts of this nematode, and cats probably become infected by ingesting them. This report aims to discuss the main anatomopathological findings of gurltiosis in a cat submitted to necropsy in a laboratory in Ribeirão Preto city, São Paulo state, southeastern Brazil, being the first case reported in this state. The main necroscopic findings were extramedullary reddened areas below the leptomeninges in the cervical and lumbar segments of the spinal cord. The histopathological examination showed marked thickening of the leptomeninges in the lumbar segment of the spinal cord, with marked neovascularization and fibrosis associated with eosinophilic and mononuclear inflammatory infiltration, as well as the presence of intravascular nematodes. The diagnosis of this lesion was chronic segmental meningomyelitis associated with intralesional parasites. Although uncommon, feline gurltiosis is a neglected parasitic disease that should be included as a differential diagnosis of paraparesis in domestic cats.
{"title":"Gurltia paralysans infection in a domestic cat in the São Paulo state, southeastern Brazil","authors":"Rafael Rocha Mello Emboaba da Costa, Júlio Edward Hough Monteiro, Claudia de Souza Silva, Fernanda Ramalho Ramos, Bethânia Almeida Gouveia, Paulo Henrique Leal Bertolo, Rosemeri de Oliveira Vasconcelos","doi":"10.24070/bjvp.1983-0246.v16i2p108-111","DOIUrl":"https://doi.org/10.24070/bjvp.1983-0246.v16i2p108-111","url":null,"abstract":"Gurltia paralysans is a nematode first described in 1933 in Chile, causing a syndrome called feline crural parasitic paraplegia. Insects, mollusks, frogs, lizards, and rodents are paratenic hosts of this nematode, and cats probably become infected by ingesting them. This report aims to discuss the main anatomopathological findings of gurltiosis in a cat submitted to necropsy in a laboratory in Ribeirão Preto city, São Paulo state, southeastern Brazil, being the first case reported in this state. The main necroscopic findings were extramedullary reddened areas below the leptomeninges in the cervical and lumbar segments of the spinal cord. The histopathological examination showed marked thickening of the leptomeninges in the lumbar segment of the spinal cord, with marked neovascularization and fibrosis associated with eosinophilic and mononuclear inflammatory infiltration, as well as the presence of intravascular nematodes. The diagnosis of this lesion was chronic segmental meningomyelitis associated with intralesional parasites. Although uncommon, feline gurltiosis is a neglected parasitic disease that should be included as a differential diagnosis of paraparesis in domestic cats.","PeriodicalId":9223,"journal":{"name":"Brazilian Journal of Veterinary Pathology","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135403660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.24070/bjvp.1983-0246.v16i2p100-102
Daniel R. Rissi
Apocrine neoplasms are rare in goats. This report describes an apocrine adenocarcinoma in a 5-year-old female Boer goat with an ulcerated, exophytic, multilobulated mass on the left dorsolateral cervical area. Histologically, the dermis was effaced and expanded by a poorly demarcated epithelial neoplasm with desmoplasia. Neoplastic cells were arranged in acini with papillary projections into the lumen and had cuboidal or columnar, eosinophilic, occasionally vacuolated cytoplasm. Nuclei were round and had finely stippled chromatin with one nucleolus. Neoplastic cells contained periodic acid-Schiff (PAS)–positive and diastase–resistant, alcian blue–positive cytoplasmic granules. There were 6 mitoses in 2.37 mm2 (equivalent to 10 FN22/40X fields). Histologic and histochemical features in the current case were consistent with a cutaneous apocrine gland adenocarcinoma.
{"title":"Cutaneous apocrine adenocarcinoma in a goat","authors":"Daniel R. Rissi","doi":"10.24070/bjvp.1983-0246.v16i2p100-102","DOIUrl":"https://doi.org/10.24070/bjvp.1983-0246.v16i2p100-102","url":null,"abstract":"Apocrine neoplasms are rare in goats. This report describes an apocrine adenocarcinoma in a 5-year-old female Boer goat with an ulcerated, exophytic, multilobulated mass on the left dorsolateral cervical area. Histologically, the dermis was effaced and expanded by a poorly demarcated epithelial neoplasm with desmoplasia. Neoplastic cells were arranged in acini with papillary projections into the lumen and had cuboidal or columnar, eosinophilic, occasionally vacuolated cytoplasm. Nuclei were round and had finely stippled chromatin with one nucleolus. Neoplastic cells contained periodic acid-Schiff (PAS)–positive and diastase–resistant, alcian blue–positive cytoplasmic granules. There were 6 mitoses in 2.37 mm2 (equivalent to 10 FN22/40X fields). Histologic and histochemical features in the current case were consistent with a cutaneous apocrine gland adenocarcinoma.","PeriodicalId":9223,"journal":{"name":"Brazilian Journal of Veterinary Pathology","volume":"51-52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135403695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.24070/bjvp.1983-0246.v16i2p139-143
Damián Jesús Castro, Guillermo Alberto Mattioli, Carlos Augusto Margineda
Bone fractures are a frequent cause of limp in cattle, being pre-existing bone lesions among the predisposing factors. However, there is scant information about the natural occurrence of bone disease. This report aimed to describe an outbreak of spontaneous fractures associated with hypocuprosis in pen-backgrounded calves. Hind limp and irreversible recumbency were noticed in 9-month-old calves of a dairy farm from Córdoba province (Argentina). The issue was only evident in males fed a diet composed (DM) of 57% wet corn, 24% dry corn distiller grains, and 19% corn silage. No mineral mix was supplied. Accumulated morbidity and fatality rates were 5.8 and 100%, respectively. Two autopsies were performed, observing multiple femoral and rib fractures. Severe hypocupremia, very low copper levels in the liver and plasma, deficient dietary copper levels, normocalcemia, marginal hypophosphatemia, and high sulfate concentrations in the water supply were determined. Except for the decreased bone quantity and the multiple fractures, no bone lesion was observed, confirming osteoporosis as the pathological diagnosis, and hypocuprosis as the etiology.
{"title":"Spontaneous fractures and hypocuprosis in pen-backgrounded Holstein calves","authors":"Damián Jesús Castro, Guillermo Alberto Mattioli, Carlos Augusto Margineda","doi":"10.24070/bjvp.1983-0246.v16i2p139-143","DOIUrl":"https://doi.org/10.24070/bjvp.1983-0246.v16i2p139-143","url":null,"abstract":"Bone fractures are a frequent cause of limp in cattle, being pre-existing bone lesions among the predisposing factors. However, there is scant information about the natural occurrence of bone disease. This report aimed to describe an outbreak of spontaneous fractures associated with hypocuprosis in pen-backgrounded calves. Hind limp and irreversible recumbency were noticed in 9-month-old calves of a dairy farm from Córdoba province (Argentina). The issue was only evident in males fed a diet composed (DM) of 57% wet corn, 24% dry corn distiller grains, and 19% corn silage. No mineral mix was supplied. Accumulated morbidity and fatality rates were 5.8 and 100%, respectively. Two autopsies were performed, observing multiple femoral and rib fractures. Severe hypocupremia, very low copper levels in the liver and plasma, deficient dietary copper levels, normocalcemia, marginal hypophosphatemia, and high sulfate concentrations in the water supply were determined. Except for the decreased bone quantity and the multiple fractures, no bone lesion was observed, confirming osteoporosis as the pathological diagnosis, and hypocuprosis as the etiology.","PeriodicalId":9223,"journal":{"name":"Brazilian Journal of Veterinary Pathology","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135442085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The African pygmy hedgehog is increasingly being kept as a pet, and studies regarding the primary diseases that affect this species are essential for advancing medicine in these animals. This report aims to describe a case of an adult male hedgehog living in captivity. The hedgehog presented progressive weight loss and lethargy. An abdominal ultrasound examination was performed, revealing a splenic mass. Therefore, symptomatic treatment was chosen. After three months, with no clinical improvement, the animal was euthanized. The cadaver underwent necropsy, and histopathological evaluation with Hematoxylin and Eosin staining revealed two distinct neoplasms in different organs: pulmonary adenocarcinoma and round cell neoplasm in the spleen. Additionally, non-neoplastic lesions were observed in other organs. The splenic tissue was subjected to an immunohistochemical diagnostic panel using IBA1, CD3, PAX5, MUM1, and AE1AE3 markers. Positive staining for IBA1 was observed, favoring the diagnosis of histiocytic sarcoma. We emphasize the importance of preventive veterinary medicine in assessing these animals' health status and detecting possible neoplastic processes. Tumors are commonly described in this species, and clinical signs usually are nonspecific, leading to the animal's death or euthanasia.
{"title":"Lung adenocarcinoma and splenic histiocytic sarcoma in an African pygmy hedgehog (Atelerix albiventris)","authors":"Isabela Coelho Zanoti, Bethânia Almeida Gouveia, Alessandra Loureiro Morales dos Santos, Fernanda Ramalho Ramos, Claudia Momo","doi":"10.24070/bjvp.1983-0246.v16i3p208-212","DOIUrl":"https://doi.org/10.24070/bjvp.1983-0246.v16i3p208-212","url":null,"abstract":"The African pygmy hedgehog is increasingly being kept as a pet, and studies regarding the primary diseases that affect this species are essential for advancing medicine in these animals. This report aims to describe a case of an adult male hedgehog living in captivity. The hedgehog presented progressive weight loss and lethargy. An abdominal ultrasound examination was performed, revealing a splenic mass. Therefore, symptomatic treatment was chosen. After three months, with no clinical improvement, the animal was euthanized. The cadaver underwent necropsy, and histopathological evaluation with Hematoxylin and Eosin staining revealed two distinct neoplasms in different organs: pulmonary adenocarcinoma and round cell neoplasm in the spleen. Additionally, non-neoplastic lesions were observed in other organs. The splenic tissue was subjected to an immunohistochemical diagnostic panel using IBA1, CD3, PAX5, MUM1, and AE1AE3 markers. Positive staining for IBA1 was observed, favoring the diagnosis of histiocytic sarcoma. We emphasize the importance of preventive veterinary medicine in assessing these animals' health status and detecting possible neoplastic processes. Tumors are commonly described in this species, and clinical signs usually are nonspecific, leading to the animal's death or euthanasia.","PeriodicalId":9223,"journal":{"name":"Brazilian Journal of Veterinary Pathology","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135448513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.24070/bjvp.1983-0246.v16i2p117-121
Gustavo Willian Pandolfo, Marcela Bruggemann de Souza Teixeira, Thierry Grima de Cristo, Taís Gaspar, Felipe Carniel, Renata Assis Casagrande
Biliary neoplasms are uncommon in cats and affect older animals. A 12-year-old female crossbreed cat showed prostration, lethargy, apathy, and severe jaundice. Ultrasonography showed distention of the gallbladder associated with severe obstruction of the bile ducts with thickening of the biliary wall, forming amorphous masses of irregular contour and heterogeneous appearance directed to the lumen measuring up to 2 cm. Necropsy showed a gallbladder with a yellowish and soft nodule measuring 3 × 3 cm, compressing the extrahepatic bile duct, occluding the passage of bile. There were also firm, yellowish multifocal to coalescing nodules in the liver, ranging from 0.5 to 1 cm, affecting 10% of the organ, in addition to lungs with firm, yellowish multifocal nodules ranging from 0.2 to 0.5 cm, affecting 20% of the organ. Histologically, gallbladder and bile ducts had malignant epithelial neoplastic proliferation, which was organized into multiple papillary and ductal projections, separated by moderate fibrovascular stroma compatible with gallbladder adenocarcinoma. The liver and lungs also contained neoplastic structures with a ductal appearance and papilliform projections identical to those observed in the gallbladder. The immunohistochemical examination (IHC) showed intense positive staining of epithelial neoplastic cells for pan-cytokeratin (AE1/AE3) and no staining for vimentin (Clone V9). The diagnosis of gallbladder adenocarcinoma with metastasis in the liver and lungs was established based on the clinical, macroscopic, histopathological, and immunohistochemical findings.
{"title":"Metastatic gallbladder adenocarcinoma in a cat","authors":"Gustavo Willian Pandolfo, Marcela Bruggemann de Souza Teixeira, Thierry Grima de Cristo, Taís Gaspar, Felipe Carniel, Renata Assis Casagrande","doi":"10.24070/bjvp.1983-0246.v16i2p117-121","DOIUrl":"https://doi.org/10.24070/bjvp.1983-0246.v16i2p117-121","url":null,"abstract":"Biliary neoplasms are uncommon in cats and affect older animals. A 12-year-old female crossbreed cat showed prostration, lethargy, apathy, and severe jaundice. Ultrasonography showed distention of the gallbladder associated with severe obstruction of the bile ducts with thickening of the biliary wall, forming amorphous masses of irregular contour and heterogeneous appearance directed to the lumen measuring up to 2 cm. Necropsy showed a gallbladder with a yellowish and soft nodule measuring 3 × 3 cm, compressing the extrahepatic bile duct, occluding the passage of bile. There were also firm, yellowish multifocal to coalescing nodules in the liver, ranging from 0.5 to 1 cm, affecting 10% of the organ, in addition to lungs with firm, yellowish multifocal nodules ranging from 0.2 to 0.5 cm, affecting 20% of the organ. Histologically, gallbladder and bile ducts had malignant epithelial neoplastic proliferation, which was organized into multiple papillary and ductal projections, separated by moderate fibrovascular stroma compatible with gallbladder adenocarcinoma. The liver and lungs also contained neoplastic structures with a ductal appearance and papilliform projections identical to those observed in the gallbladder. The immunohistochemical examination (IHC) showed intense positive staining of epithelial neoplastic cells for pan-cytokeratin (AE1/AE3) and no staining for vimentin (Clone V9). The diagnosis of gallbladder adenocarcinoma with metastasis in the liver and lungs was established based on the clinical, macroscopic, histopathological, and immunohistochemical findings.","PeriodicalId":9223,"journal":{"name":"Brazilian Journal of Veterinary Pathology","volume":"121 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135445790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.24070/bjvp.1983-0246.v16i3p225-227
Jamile M Garcia, Luiz A S Silva, Nathalia S R Elias, Andressa G C Nitrini, Ticiana B Ervedosa, Maria Lucia Z Dagli, Claudia Momo
Sialocele is a lesion characterized by a cavity filled with saliva and delimited by granulation tissue and is the most commonly observed condition in dogs' salivary glands. A cervical swelling was observed in a male, mixed breed, 12-year-old dog. When punctured, the local was filled with saliva. The animal was referred for sialoadenectomy, and bilateral involvement was observed, with stony material delimiting the sialoceles on both sides. Samples were sent for histopathological examination, which showed cavity areas without epithelial delimitation, with osseous metaplasia and chronic inflammation. Such characteristics allowed the diagnosis of bilateral sialocele associated with osseous metaplasia. The presence of osseous metaplasia in sialoceles is extremely rare, with only four other cases described, which makes it difficult to reach conclusions related to epidemiology and pathogenesis.
{"title":"Bilateral sialocele associated with osseous metaplasia in a dog","authors":"Jamile M Garcia, Luiz A S Silva, Nathalia S R Elias, Andressa G C Nitrini, Ticiana B Ervedosa, Maria Lucia Z Dagli, Claudia Momo","doi":"10.24070/bjvp.1983-0246.v16i3p225-227","DOIUrl":"https://doi.org/10.24070/bjvp.1983-0246.v16i3p225-227","url":null,"abstract":"Sialocele is a lesion characterized by a cavity filled with saliva and delimited by granulation tissue and is the most commonly observed condition in dogs' salivary glands. A cervical swelling was observed in a male, mixed breed, 12-year-old dog. When punctured, the local was filled with saliva. The animal was referred for sialoadenectomy, and bilateral involvement was observed, with stony material delimiting the sialoceles on both sides. Samples were sent for histopathological examination, which showed cavity areas without epithelial delimitation, with osseous metaplasia and chronic inflammation. Such characteristics allowed the diagnosis of bilateral sialocele associated with osseous metaplasia. The presence of osseous metaplasia in sialoceles is extremely rare, with only four other cases described, which makes it difficult to reach conclusions related to epidemiology and pathogenesis.","PeriodicalId":9223,"journal":{"name":"Brazilian Journal of Veterinary Pathology","volume":"157 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135448514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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