Pub Date : 2022-03-31DOI: 10.24070/bjvp.1983-0246.v15i1p20-30
L. C. Nascimento-Hama, R. Vasconcelos, A. D. de Nardi, A. C. de Camargo, Larissa R. Marchini, F. D. L. Rocha, B. Firmo, C. V. Estrada, S. Artoni, N. Nunes, A. R. Panosso, L. Amoroso
Overweight and obesity are known risk factors that are involved in the development and aggressiveness of breast tumors in women. In situations of obesity, local and systemic inflammation may worsen the prognosis of oncological patients. Moreover, hypovitaminosis D increases the risk of breast tumors in women. In female dogs, low vitamin D levels have been found in cases of lymphoma, osteosarcoma and mast cell tumor. The present study aimed to make correlations between body fat composition and serum 25(OH)D concentration in female dogs with mammary tumors. Two experimental groups were formed: healthy female dogs (n = 12; control group) and female dogs with mammary tumors (n = 11). An analysis on body composition was performed using dual-energy X-ray absorptiometry (DXA) equipment. In the tumor group, multicentric nodules were most prevalent (63,6%), with diameters of up to 8.2 cm. The most frequent histopathological diagnosis was tubular carcinoma (45.5%), and 9.1% presented metastases in axillary lymph nodes. The mean 25(OH)D concentration in the female dogs with mammary tumors (37.6 ng mL-1) was lower than the level in the control group (65.4 ng mL-1). Multivariate statistical analysis showed that elderly female dogs with malignant mammary tumors and high body fat levels presented lower 25(OH)D concentrations than those of the control group. It was concluded that female dogs with higher body adiposity presented mammary tumors of higher aggressivity, and that the higher the fat percentage was in the female dogs with malignant mammary tumors, the lower their vitamin D concentration was.
超重和肥胖是已知的与女性乳腺肿瘤的发展和侵袭性有关的危险因素。在肥胖的情况下，局部和全身炎症可能会恶化肿瘤患者的预后。此外，维生素D缺乏症会增加女性患乳腺肿瘤的风险。在雌性犬中，在淋巴瘤、骨肉瘤和肥大细胞瘤的病例中发现维生素D水平低。本研究旨在探讨雌性乳腺肿瘤犬体脂组成与血清25(OH)D浓度的相关性。实验分为两组:健康母狗(n = 12);对照组)和乳腺肿瘤母犬(n = 11)。采用双能x射线吸收仪(DXA)设备进行体成分分析。在肿瘤组中，多中心结节最为常见(63.6%)，直径可达8.2 cm。最常见的组织病理学诊断为小管癌(45.5%)，9.1%为腋窝淋巴结转移。雌性乳腺肿瘤犬体内25(OH)D平均浓度(37.6 ng mL-1)低于对照组(65.4 ng mL-1)。多因素统计分析显示，患有恶性乳腺肿瘤、体脂水平较高的老年母犬25(OH)D浓度低于对照组。由此可见，体脂率高的母狗乳腺肿瘤具有较高的侵袭性，恶性乳腺肿瘤母狗脂肪率越高，其维生素D浓度越低。
{"title":"Association between vitamin D and malignant mammary tumors in obese female dogs","authors":"L. C. Nascimento-Hama, R. Vasconcelos, A. D. de Nardi, A. C. de Camargo, Larissa R. Marchini, F. D. L. Rocha, B. Firmo, C. V. Estrada, S. Artoni, N. Nunes, A. R. Panosso, L. Amoroso","doi":"10.24070/bjvp.1983-0246.v15i1p20-30","DOIUrl":"https://doi.org/10.24070/bjvp.1983-0246.v15i1p20-30","url":null,"abstract":"Overweight and obesity are known risk factors that are involved in the development and aggressiveness of breast tumors in women. In situations of obesity, local and systemic inflammation may worsen the prognosis of oncological patients. Moreover, hypovitaminosis D increases the risk of breast tumors in women. In female dogs, low vitamin D levels have been found in cases of lymphoma, osteosarcoma and mast cell tumor. The present study aimed to make correlations between body fat composition and serum 25(OH)D concentration in female dogs with mammary tumors. Two experimental groups were formed: healthy female dogs (n = 12; control group) and female dogs with mammary tumors (n = 11). An analysis on body composition was performed using dual-energy X-ray absorptiometry (DXA) equipment. In the tumor group, multicentric nodules were most prevalent (63,6%), with diameters of up to 8.2 cm. The most frequent histopathological diagnosis was tubular carcinoma (45.5%), and 9.1% presented metastases in axillary lymph nodes. The mean 25(OH)D concentration in the female dogs with mammary tumors (37.6 ng mL-1) was lower than the level in the control group (65.4 ng mL-1). Multivariate statistical analysis showed that elderly female dogs with malignant mammary tumors and high body fat levels presented lower 25(OH)D concentrations than those of the control group. It was concluded that female dogs with higher body adiposity presented mammary tumors of higher aggressivity, and that the higher the fat percentage was in the female dogs with malignant mammary tumors, the lower their vitamin D concentration was.","PeriodicalId":9223,"journal":{"name":"Brazilian Journal of Veterinary Pathology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45181279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-31DOI: 10.24070/bjvp.1983-0246.v15i1p62-64
D. B. Murillo, Tatiane Watanabe, S. Perry, Mark T. Mitchell, F. Del Piero
An adult of unknown age, intact female bearded dragon (Pogona sp.) had multiple ulcerative foci in the skin, especially noted in the ventral neck and along the inguinal area. Due to the severity and extension of the epidermal/dermal lesions, as well as, the deleterious animal condition, the owners elected humane euthanasia and postmortem examination was performed. Necropsy Findings: The skin at the level of the ventral mandible, neck, thorax, and inguinal areas was replaced by multifocal to coalescing ulcerative foci ranging from 1.5 x 2 x 0.3 cm to 2.5 x 2.5 x 0.3 cm associated with sloughed epithelium covered by a thin yellow to light brown friable material (Figure 1A-C). Similar material was noted above the right eye and the abdomen. No other significant alterations were noted.
一只年龄不详的成年雌性须龙（Pogona sp.）的皮肤上有多个溃疡灶，尤其是在腹侧颈部和腹股沟区域。由于表皮/真皮损伤的严重性和扩展性，以及有害的动物状况，主人选择了人道安乐死，并进行了尸检。尸检结果：下颌骨腹侧、颈部、胸部和腹股沟区域的皮肤被范围为1.5 x 2 x 0.3 cm至2.5 x 2.5 x 0.3 cm的多灶性至聚结性溃疡灶所取代，溃疡灶与由薄黄色至浅棕色脆性材料覆盖的脱落上皮有关（图1A-C）。右眼和腹部上方也发现了类似的物质。未发现其他显著变化。
{"title":"Yellow fungus disease in a bearded dragon","authors":"D. B. Murillo, Tatiane Watanabe, S. Perry, Mark T. Mitchell, F. Del Piero","doi":"10.24070/bjvp.1983-0246.v15i1p62-64","DOIUrl":"https://doi.org/10.24070/bjvp.1983-0246.v15i1p62-64","url":null,"abstract":"An adult of unknown age, intact female bearded dragon (Pogona sp.) had multiple ulcerative foci in the skin, especially noted in the ventral neck and along the inguinal area. Due to the severity and extension of the epidermal/dermal lesions, as well as, the deleterious animal condition, the owners elected humane euthanasia and postmortem examination was performed. Necropsy Findings: The skin at the level of the ventral mandible, neck, thorax, and inguinal areas was replaced by multifocal to coalescing ulcerative foci ranging from 1.5 x 2 x 0.3 cm to 2.5 x 2.5 x 0.3 cm associated with sloughed epithelium covered by a thin yellow to light brown friable material (Figure 1A-C). Similar material was noted above the right eye and the abdomen. No other significant alterations were noted.","PeriodicalId":9223,"journal":{"name":"Brazilian Journal of Veterinary Pathology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49130574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-31DOI: 10.24070/bjvp.1983-0246.v15i1p54-56
T. G. Bizari, B. F. Lautert, R. S. de Sousa
Animals in human care often exceed the life expectancy of animals in the wild when they have veterinarian follow-ups, no competition for space or food, and continuous care. Advanced age favors the development of mutations that often trigger cancer, which sometimes causes death. There are reports in the literature on neoplasms in lions in the liver, which are one of the main organs affected. A 20-year-old lion specimen was received for necropsy at the Federal University of Paraná, Curitiba, Brazil. Multiple cystic dilations were observed in the liver. Histologically, they were internally covered by a simple cuboidal epithelium, similar to that observed in the bile ducts, without cellular atypia. The adjacent liver parenchyma presented with mild disorganization of the hepatocyte cords. Biliary cystadenomas are benign growths formed by a thin opaque capsule filled with a slightly yellowish translucent fluid compressing the adjacent liver parenchyma, as highlighted in this case. The epithelium of the cysts was positive for anti-cytokeratin (CK) (EIA/A3E) and anti-CK7, confirming histogenesis in the bile ducts. This study reports a case of biliary cystadenoma in a Panthera leo specimen.
{"title":"Biliary cystadenoma in a lion (Panthera leo)","authors":"T. G. Bizari, B. F. Lautert, R. S. de Sousa","doi":"10.24070/bjvp.1983-0246.v15i1p54-56","DOIUrl":"https://doi.org/10.24070/bjvp.1983-0246.v15i1p54-56","url":null,"abstract":"Animals in human care often exceed the life expectancy of animals in the wild when they have veterinarian follow-ups, no competition for space or food, and continuous care. Advanced age favors the development of mutations that often trigger cancer, which sometimes causes death. There are reports in the literature on neoplasms in lions in the liver, which are one of the main organs affected. A 20-year-old lion specimen was received for necropsy at the Federal University of Paraná, Curitiba, Brazil. Multiple cystic dilations were observed in the liver. Histologically, they were internally covered by a simple cuboidal epithelium, similar to that observed in the bile ducts, without cellular atypia. The adjacent liver parenchyma presented with mild disorganization of the hepatocyte cords. Biliary cystadenomas are benign growths formed by a thin opaque capsule filled with a slightly yellowish translucent fluid compressing the adjacent liver parenchyma, as highlighted in this case. The epithelium of the cysts was positive for anti-cytokeratin (CK) (EIA/A3E) and anti-CK7, confirming histogenesis in the bile ducts. This study reports a case of biliary cystadenoma in a Panthera leo specimen.","PeriodicalId":9223,"journal":{"name":"Brazilian Journal of Veterinary Pathology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46072720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-31DOI: 10.24070/bjvp.1983-0246.v15i1p1-10
De Alves, Alexandre Matheus Baesso Cavalca, Carlos Eduardo Fonseca Alves
Squamous cell carcinoma (SCC) is a common neoplastic skin disease that is highly prevalent in tropical countries. As the skin has a variety of cells, overexposure to environmental factors, such as ultraviolet light, can affect this organ, resulting in malignancies, such as cutaneous SCC, hemangioma, and hemangiosarcoma. SCC arises from keratinocytes in the skin and is locally invasive with low metastatic rates, commonly affecting unpigmented skin in sites with high exposure to sunlight, such as ventral regions. SCC has a variable etiology that is not well understood. Therefore, literature review aimed to critically evaluate the risk factors involved in the SCC development.
{"title":"A Critical Review of the risk factors associated with Canine Squamous Cell Carcinoma development","authors":"De Alves, Alexandre Matheus Baesso Cavalca, Carlos Eduardo Fonseca Alves","doi":"10.24070/bjvp.1983-0246.v15i1p1-10","DOIUrl":"https://doi.org/10.24070/bjvp.1983-0246.v15i1p1-10","url":null,"abstract":"Squamous cell carcinoma (SCC) is a common neoplastic skin disease that is highly prevalent in tropical countries. As the skin has a variety of cells, overexposure to environmental factors, such as ultraviolet light, can affect this organ, resulting in malignancies, such as cutaneous SCC, hemangioma, and hemangiosarcoma. SCC arises from keratinocytes in the skin and is locally invasive with low metastatic rates, commonly affecting unpigmented skin in sites with high exposure to sunlight, such as ventral regions. SCC has a variable etiology that is not well understood. Therefore, literature review aimed to critically evaluate the risk factors involved in the SCC development.","PeriodicalId":9223,"journal":{"name":"Brazilian Journal of Veterinary Pathology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44448741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-31DOI: 10.24070/bjvp.1983-0246.v15i1p65-68
N. Streitenberger, J. Asín, M. Navarro, R. Poppenga, F. Uzal
Clinical History: Two 18-month-old female bison and a heifer died suddenly in the same ranch. The three animals were submitted for postmortem examination and diagnostic workup. The changes of one of the bison are presented here. Necropsy Findings: The carcass was in fair nutritional condition, with small amount of fat reserves, but still well fleshed, and in mild state of post-mortem decomposition. There was a small amount of clotted dark-red blood in the nostrils and anus. The heart presented extensive sub-endocardial hemorrhages in all four chambers. These lesions were most pronounced in both ventricles where they extended deep into the underlying myocardium (Figs. 1 and 2). The mucosa of the abomasum was diffusely and mildly congested, and the mucosa of the small and large intestine was diffusely and severely congested (Fig. 3). There was a moderate amount of red fluid in the lumen of the small intestine, cecum, and colon. Both lungs had a few, small, welldelineated, deep, firm, multifocal dark-red areas in all pulmonary lobes, but lung tissue samples floated when placed into formalin.
{"title":"Oleander (Nerium oleander) intoxication in a bison","authors":"N. Streitenberger, J. Asín, M. Navarro, R. Poppenga, F. Uzal","doi":"10.24070/bjvp.1983-0246.v15i1p65-68","DOIUrl":"https://doi.org/10.24070/bjvp.1983-0246.v15i1p65-68","url":null,"abstract":"Clinical History: Two 18-month-old female bison and a heifer died suddenly in the same ranch. The three animals were submitted for postmortem examination and diagnostic workup. The changes of one of the bison are presented here. Necropsy Findings: The carcass was in fair nutritional condition, with small amount of fat reserves, but still well fleshed, and in mild state of post-mortem decomposition. There was a small amount of clotted dark-red blood in the nostrils and anus. The heart presented extensive sub-endocardial hemorrhages in all four chambers. These lesions were most pronounced in both ventricles where they extended deep into the underlying myocardium (Figs. 1 and 2). The mucosa of the abomasum was diffusely and mildly congested, and the mucosa of the small and large intestine was diffusely and severely congested (Fig. 3). There was a moderate amount of red fluid in the lumen of the small intestine, cecum, and colon. Both lungs had a few, small, welldelineated, deep, firm, multifocal dark-red areas in all pulmonary lobes, but lung tissue samples floated when placed into formalin.","PeriodicalId":9223,"journal":{"name":"Brazilian Journal of Veterinary Pathology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42636145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-31DOI: 10.24070/bjvp.1983-0246.v15i1p69-72
Emily Hoskins, L. Stranahan, A. Blue-McLendon, R. Rech
Clinical History: A 25-year-old female emu (Dromaius novaehollandiae) presented with a 1-week history of lethargy, hyporexia, and recumbency. The bird had lived its entire life at the Winnie Carter Wildlife Center in Texas and had an unremarkable medical history, apart from bilateral congenital blindness. Necropsy Findings: Within the coelomic cavity, the serosal surface of the intestines was coated with a moderate amount of tan to green, mucoid, opaque, foul-smelling fluid (fibrinoheterophilic coelomitis) (Fig. 1). The large intestine was diffusely dilated and filled with dark red fluid and strands of yellow, friable material (fibrin). The mucosa of the small intestine, and most severely the colon, was diffusely roughened, thickened, dull, and covered by a thick yellow to green, opaque, friable diphtheritic membrane (Fig. 2). The distal colon was diffusely, markedly distended and focally contained a 50x7x5 cm, semi-firm accumulation of feces coated by a 4-5 mm diameter layer of tan, friable material (fibrin) located 21 cm from the opening of the cloaca. Gross evaluation of the eyes revealed bilateral aphakia.
{"title":"Clostridial enterocolitis in an emu (Dromaius novaehollandiae)","authors":"Emily Hoskins, L. Stranahan, A. Blue-McLendon, R. Rech","doi":"10.24070/bjvp.1983-0246.v15i1p69-72","DOIUrl":"https://doi.org/10.24070/bjvp.1983-0246.v15i1p69-72","url":null,"abstract":"Clinical History: A 25-year-old female emu (Dromaius novaehollandiae) presented with a 1-week history of lethargy, hyporexia, and recumbency. The bird had lived its entire life at the Winnie Carter Wildlife Center in Texas and had an unremarkable medical history, apart from bilateral congenital blindness. Necropsy Findings: Within the coelomic cavity, the serosal surface of the intestines was coated with a moderate amount of tan to green, mucoid, opaque, foul-smelling fluid (fibrinoheterophilic coelomitis) (Fig. 1). The large intestine was diffusely dilated and filled with dark red fluid and strands of yellow, friable material (fibrin). The mucosa of the small intestine, and most severely the colon, was diffusely roughened, thickened, dull, and covered by a thick yellow to green, opaque, friable diphtheritic membrane (Fig. 2). The distal colon was diffusely, markedly distended and focally contained a 50x7x5 cm, semi-firm accumulation of feces coated by a 4-5 mm diameter layer of tan, friable material (fibrin) located 21 cm from the opening of the cloaca. Gross evaluation of the eyes revealed bilateral aphakia.","PeriodicalId":9223,"journal":{"name":"Brazilian Journal of Veterinary Pathology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41969001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-31DOI: 10.24070/bjvp.1983-0246.v15i1p50-53
Lorena S. Bezerra, R. Eloi, André M. Santos, L. B. de Oliveira, José Araújo, G. Blume
Pericardial defects are considered rare in animals and humans. Pericardial agenesis is characterized by partial or total pericardial sac malformation. Here is reported a case of apical partial pericardial agenesis in an adult mixed-breed male dog referred for necropsy. The pericardial sac was absent from the apical region up to the middle area of the ventricles resulting in a bilateral ventricular compression by the remaining pericardium changed the organ conformation. Microscopically, there was evidence of neutrophilic and hemorrhagic myocarditis with cardiomyocyte atrophy and interstitial fibrosis. Agenesis is often a subclinical disorder, and it is an incidental postmortem finding in most cases; however, it can cause complications in cases of cardiac structure herniation.
{"title":"Partial pericardial agenesis in a dog","authors":"Lorena S. Bezerra, R. Eloi, André M. Santos, L. B. de Oliveira, José Araújo, G. Blume","doi":"10.24070/bjvp.1983-0246.v15i1p50-53","DOIUrl":"https://doi.org/10.24070/bjvp.1983-0246.v15i1p50-53","url":null,"abstract":"Pericardial defects are considered rare in animals and humans. Pericardial agenesis is characterized by partial or total pericardial sac malformation. Here is reported a case of apical partial pericardial agenesis in an adult mixed-breed male dog referred for necropsy. The pericardial sac was absent from the apical region up to the middle area of the ventricles resulting in a bilateral ventricular compression by the remaining pericardium changed the organ conformation. Microscopically, there was evidence of neutrophilic and hemorrhagic myocarditis with cardiomyocyte atrophy and interstitial fibrosis. Agenesis is often a subclinical disorder, and it is an incidental postmortem finding in most cases; however, it can cause complications in cases of cardiac structure herniation.","PeriodicalId":9223,"journal":{"name":"Brazilian Journal of Veterinary Pathology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41996339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-11-30DOI: 10.24070/bjvp.1983-0246.v14i3p180-187
T. Carvalho, D. D. Dos Santos, A. D. de Oliveira, S. Pimentel, H. Tinoco, C. Coelho, A. Gonçalves, R. Xavier, Rodrigo Silva, Renato Lima Santos
Trueperella pyogenes is an opportunistic pathogen, most commonly affecting ruminants and pigs. A female free-ranging gray brocket deer (Mazama gouazoubira) had an abscess in the masseter muscle associated with an osteolysis and osteomyelitis in the adjacent right mandibule, with a fistulous tract to the orbit and through the optic foramen into the skull, causing a suppurative meningitis. Histologically, the abscess was characterized by a neutrophilic and histiocytic inflammatory infiltrate with myriad of Gram-positive rod-shaped bacteria, and a focally extensive suppurative and histiocytic leptomeningitis of the ventral portions of the brain. Aerobic microbiologic culture, MALDI-ToF, and PCR identified T. pyogenes.
{"title":"Suppurative meningoencephalitis secondary to a Trueperella pyogenes-induced mandibular abscess in a free-ranging gray brocket deer (Mazama gouazoubira)","authors":"T. Carvalho, D. D. Dos Santos, A. D. de Oliveira, S. Pimentel, H. Tinoco, C. Coelho, A. Gonçalves, R. Xavier, Rodrigo Silva, Renato Lima Santos","doi":"10.24070/bjvp.1983-0246.v14i3p180-187","DOIUrl":"https://doi.org/10.24070/bjvp.1983-0246.v14i3p180-187","url":null,"abstract":"Trueperella pyogenes is an opportunistic pathogen, most commonly affecting ruminants and pigs. A female free-ranging gray brocket deer (Mazama gouazoubira) had an abscess in the masseter muscle associated with an osteolysis and osteomyelitis in the adjacent right mandibule, with a fistulous tract to the orbit and through the optic foramen into the skull, causing a suppurative meningitis. Histologically, the abscess was characterized by a neutrophilic and histiocytic inflammatory infiltrate with myriad of Gram-positive rod-shaped bacteria, and a focally extensive suppurative and histiocytic leptomeningitis of the ventral portions of the brain. Aerobic microbiologic culture, MALDI-ToF, and PCR identified T. pyogenes.","PeriodicalId":9223,"journal":{"name":"Brazilian Journal of Veterinary Pathology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41466813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-11-01DOI: 10.24070/bjvp.1983-0246.v14i3p145-150
L. Gomes, Ê. Ferreira, I. Oliveira, C. Campos, H. Gobbi, G. Cassali
Expression of cadherins has been correlated to the development and aggressiveness of epithelial neoplasms, however, in canine mammary tumors, their significance prognostic is uncertain. Due to this fact, the expression of the intracellular adhesion molecules E and P-cadherin and correlation with overall survival were analyzed in 25 canine mammary gland tumors. E-cadherin expression reduction was correlated with histological type, high histological grade, and overall survival rate. P-cadherin staining was higher in malignant tumors, unrelated to other clinicopathological features of aggressiveness. The results of this study suggest a relationship between lower expression of E and P-cadherin and worse prognostic in canine mammary tumors, including shorter overall survival.
{"title":"Prognostic impact of alterations in E-cadherin and P-cadherin expression in canine mammary tumors","authors":"L. Gomes, Ê. Ferreira, I. Oliveira, C. Campos, H. Gobbi, G. Cassali","doi":"10.24070/bjvp.1983-0246.v14i3p145-150","DOIUrl":"https://doi.org/10.24070/bjvp.1983-0246.v14i3p145-150","url":null,"abstract":"Expression of cadherins has been correlated to the development and aggressiveness of epithelial neoplasms, however, in canine mammary tumors, their significance prognostic is uncertain. Due to this fact, the expression of the intracellular adhesion molecules E and P-cadherin and correlation with overall survival were analyzed in 25 canine mammary gland tumors. E-cadherin expression reduction was correlated with histological type, high histological grade, and overall survival rate. P-cadherin staining was higher in malignant tumors, unrelated to other clinicopathological features of aggressiveness. The results of this study suggest a relationship between lower expression of E and P-cadherin and worse prognostic in canine mammary tumors, including shorter overall survival.","PeriodicalId":9223,"journal":{"name":"Brazilian Journal of Veterinary Pathology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42072589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-11-01DOI: 10.24070/bjvp.1983-0246.v14i3p151-158
E. Cavalcanti, L. Gorza, Bruna V. Sena, B. Sossai, Moacir Carreta Junior, M. Flecher, C. Marcolongo-Pereira, R. Horta
Soft-tissue sarcomas (STS) represent a heterogeneous group of tumours with similar histological characteristics and biological behaviour. This study aimed to describe the correlation between clinical, histopathological and histomorphometric features of STS in dogs. Medical records were reviewed to identify all dogs in which an STS was diagnosed between 2006-2017. Thirty cases were included, and tumour samples and medical records were recovered. Most of the dogs were mixed breed (40%) and 80% of the STS were located in the subcutaneous connective tissue. Histopathological classification showed that undifferentiated sarcoma (17%) and peripheral nerve sheath tumour (30%) were the most common STS. Grade I STS were obtained in 50% of cases (15/30), and grade II or III tumours compromised 43% (13/30) and 7% (2/30) respectively. The mitotic index ranged from zero to 26 (5.8 ± 7.5). Increased nucleus:cytoplasm ratio was moderately associated with higher tumour grade (p = 0.05; rS = 0.361) and mitotic index (p = 0.05; rS = 0.355), while the number of microvessels was positively correlated with degree of differentiation (p = 0.05; rS = 0.362) and nuclear pleomorphism (p = 0.036; rS = 0.384). Histomorphometry proved to be useful in the evaluation of STS, representing an additional tool correlated with well-established prognostic factors (histopathological grade, degree of differentiation, nuclear pleomorphism).
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