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Evaluation of coumarin and their derivatives as Janus Kinase-3 inhibitors using a theoretical model 用理论模型评价香豆素及其衍生物作为Janus Kinase-3抑制剂的作用
IF 1.1 4区 农林科学 Q3 AGRICULTURE, DAIRY & ANIMAL SCIENCE Pub Date : 2023-06-30 DOI: 10.14295/bjs.v2i12.423
L. Figueroa-Valverde, López-Ramos Maria, Alvarez-Ramirez Magdalena, Rosas-Nexticapa Marcela, D. Francisco, M. Virginia, Lopez-Gutierrez Tomas
For several years, cancer has increased in the population, being one of the main causes of death worldwide. This clinical pathology is associated with the activation/release of various biomolecules, including the Janus kinase family (JAKs). It is important to mention that some studies indicate that some JAK inhibitors (ruxolitinib and tofacitinib) may have a significant effect on some autoimmune diseases and cancer; however, some of these drugs can produce secondary effects such as herpes zoster, infectious, acute respiratory distress and others. The aim of this study was to evaluate the interaction of coumarin and its derivatives (compounds 2 to 24) with the JAK-3 surface. In this way, the Interaction of coumarin and their derivatives with JAK-3 was determined using the 3pjc protein and either decernotinib or tofacitinib drugs as theoretical tools on DockinServer program. The results showed differences in the aminoacid residues involved in the interaction of coumarin and their derivatives with 3pjc protein surface compared with decernotinib and tofacitinib. Besides, the inhibition constant (Ki) for coumarin derivatives 7, 9 and 10 was lower compared with tofacitinib. However, Ki was lower for 2, 5, 7, 8, 9, 10, and 24 compared with decernotinib. In conclusion, the coumarin derivatives 2, 5, 7, 8, 9, 10, and 24 could be good alternatives as JAK-3 inhibitors to decrease cancer cells growth.  
几年来,癌症在人口中有所增加,成为世界范围内死亡的主要原因之一。这种临床病理与各种生物分子的激活/释放有关,包括Janus激酶家族(JAKs)。值得一提的是,一些研究表明,一些JAK抑制剂(ruxolitinib和tofacitinib)可能对某些自身免疫性疾病和癌症有显著影响;然而,其中一些药物会产生继发性影响,如带状疱疹、传染性、急性呼吸窘迫等。本研究的目的是评价香豆素及其衍生物(化合物2 ~ 24)与JAK-3表面的相互作用。这样,在DockinServer程序上,以3pjc蛋白和decernotinib或tofacitinib药物为理论工具,确定香豆素及其衍生物与JAK-3的相互作用。结果表明,与decernotinib和tofacitinib相比,香豆素及其衍生物与3pjc蛋白表面相互作用所涉及的氨基酸残基存在差异。与托法替尼相比,香豆素衍生物7、9和10的抑制常数(Ki)更低。然而,与decernotinib相比,Ki在2、5、7、8、9、10和24时较低。总之,香豆素衍生物2、5、7、8、9、10和24可作为JAK-3抑制剂的良好替代品,抑制癌细胞的生长。
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引用次数: 0
Assistive technology for autism spectrum disorder children that experiences stress and anxiety 自闭症谱系障碍儿童的辅助技术,经历压力和焦虑
IF 1.1 4区 农林科学 Q3 AGRICULTURE, DAIRY & ANIMAL SCIENCE Pub Date : 2023-06-30 DOI: 10.14295/bjs.v2i12.426
Pantelis Pergantis, A. Drigas
With the development of current technology and influences that have been made by the Industry 4.0 utilizing ICTs, IoT, smart systems and products and many others, Assistive Technology (AT) is an important and integral part of the daily life of many people who experience disabilities. Autism Spectrum Disorder (ASD) is a special category of disorder that can greatly benefit from its use. The purpose of this research is to collect data of Assistive Technology aimed at the detection, prevention and improvement of anxiety and stress (a characteristic of which has been proven to exist and is expressed in various ways in people with ASD). In the introduction, basic definitions regarding the neurobiology of stress and ASD are analyzed. In the main part AT, stress and anxiety correlations are made with ASD and AT devices are described and documented regarding their use for anxiety and stress in children and adolescents with ASD. The Assistive equipment and devices are divided into 2 main categories, 1) Low-tech and 2) Mid-High tech. The results of the research reveal a significant research gap in the use of AT to combat stress and anxiety and the difficulty of many promising options (especially in the domain of Mid-High tech) to be an easy and economical solution in integrating them into the daily life of people with ASD.
随着当前技术的发展以及工业4.0利用信息通信技术、物联网、智能系统和产品等带来的影响,辅助技术(AT)已成为许多残疾人日常生活中重要而不可或缺的一部分。自闭症谱系障碍(ASD)是一种特殊类型的障碍,可以从它的使用中受益匪浅。本研究的目的是收集辅助技术的数据,旨在检测、预防和改善焦虑和压力(这是一种已被证明存在的特征,并在ASD患者中以各种方式表达)。在引言部分,对应激和ASD的神经生物学基本定义进行了分析。在主要部分,压力和焦虑与ASD之间的相关性,以及AT设备在ASD儿童和青少年中用于焦虑和压力的描述和记录。辅助设备和装置分为两大类,1)低技术和2)中高技术。研究结果表明,在使用辅助设备来对抗压力和焦虑方面存在显著的研究差距,许多有前途的选择(特别是在中高技术领域)很难成为一种简单而经济的解决方案,将它们融入ASD患者的日常生活。
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引用次数: 1
Sensory integration therapy as enabler for developing emotional intelligence in children with autism spectrum disorder and the ICT’s role 感觉统合疗法对自闭症谱系障碍儿童情绪智力发展的促进作用及其作用
IF 1.1 4区 农林科学 Q3 AGRICULTURE, DAIRY & ANIMAL SCIENCE Pub Date : 2023-06-29 DOI: 10.14295/bjs.v2i12.422
Pantelis Pergantis, A. Drigas
Sensory Integration Therapy (SIT) is a widely known and used intervention by a lot of professionals and practitioners in the field of special education as being an enabler of functionality of the child. Through intervention, the sensory processing components that have been affected are targeted. Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder that is highly affected by sensory modulation disorder (SMD), a special subcategory of sensory processing disorder (SPD) that is expressed in various ways causing activation of Autonomic Nervous System (ANS) leading to biological and physiological stress. Emotional Intelligence (EI) is a complex set of skills that drive us to higher mental states. According to theorists the basis of these skills is the ability to manage and regulate stimulus. The purpose of this literature review is to investigate the connections between SIT and EI in children with ASD. In the introduction basic definitions and concepts of ASD and SIT are analyzed and in the main part correlations between EI and SMD are made, discussing the effectiveness of SIT in ASD children.
感觉统合疗法(SIT)是一种广为人知的干预方法,被许多特殊教育领域的专业人士和从业者使用,作为儿童功能的推动者。通过干预,已经受到影响的感觉处理组件是有针对性的。自闭症谱系障碍(ASD)是一种高度受感觉调节障碍(SMD)影响的神经发育障碍,SMD是感觉加工障碍(SPD)的一个特殊子类,以各种方式表达,引起自主神经系统(ANS)的激活,导致生物和生理应激。情商(EI)是一套复杂的技能,它驱使我们进入更高的精神状态。根据理论家的说法,这些技能的基础是管理和调节刺激的能力。本文献综述的目的是探讨自闭症儿童的SIT和EI之间的联系。在引言部分分析了ASD和SIT的基本定义和概念,并在正文部分分析了EI和SMD之间的相关性,讨论了SIT在ASD儿童中的有效性。
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引用次数: 1
Effects of logic glitch and (area-power dissipation) leakage on cryptosystems using clock gating technique to enhance web etiquette 利用时钟门控技术提高网络礼仪的逻辑故障和(面积功耗)泄漏对密码系统的影响
IF 1.1 4区 农林科学 Q3 AGRICULTURE, DAIRY & ANIMAL SCIENCE Pub Date : 2023-06-29 DOI: 10.14295/bjs.v2i12.364
Akhigbe-mudu Thursday Ehis
The last century has seen an evolution in technology that has improved communication systems and, in general, made life easier for people. Our communication systems have become faster and more dependable as a result of the explosion of gadgets and services. But, these upgrades come at a price. The power consumption is one of the most worrying costs. In recent years, the solution involved installing larger, more powerful batteries—so long as doing so did not limit mobility. Today's economic and environmental problems compel us to consider alternative solutions, like methods for lowering the power consumption of digital devices. This study focuses on using digital circuits, which promise to deliver good energy efficiency and desirable performance at very low voltage savings. Certain digital switches are allegedly redundant and not required for the circuit to function properly, yet they continue to use energy. So, one of the primary issues for low power design is reducing such redundant switches. Subthreshold conduction in digital circuits is typically seen as a “parasitic” leakage in a condition where there should ideally be no conduction. Sub-threshold activities thereby reduce the problem of lowering power consumption, but do so at the expense of system throughput deterioration, fluctuations in system stability and functionality, temperature variations, and most critically, design space utilization. In order to minimize some of these redundant switches and to make circuits more energy-efficient while maintaining functionality, this study suggests two novel techniques. It uses an optimization method based on threshold voltage change to reduce glitch power. A glitch-free circuit netlist is created using an algorithm, while still maintaining the requisite delay performance. Using this approach results in a 6.14% overall reduction in energy consumption.
上个世纪见证了技术的发展,它改善了通信系统,总体上使人们的生活更加便利。由于电子设备和服务的爆炸式增长,我们的通信系统变得更快、更可靠。但是,这些升级是有代价的。电力消耗是最令人担忧的成本之一。近年来,解决方案包括安装更大、更强大的电池——只要这样做不会限制移动性。当今的经济和环境问题迫使我们考虑其他解决方案,比如降低数字设备功耗的方法。这项研究的重点是使用数字电路,它有望在非常低的电压节约下提供良好的能源效率和理想的性能。据称,某些数字开关是冗余的,不需要电路正常工作,但它们继续使用能量。因此,低功耗设计的主要问题之一是减少冗余开关。在数字电路中,阈下传导通常被视为“寄生”漏,在理想情况下,应该没有传导。亚阈值活动因此减少了降低功耗的问题,但这样做的代价是系统吞吐量下降、系统稳定性和功能波动、温度变化,以及最关键的设计空间利用率。为了尽量减少这些冗余开关,并在保持功能的同时使电路更节能,这项研究提出了两种新技术。采用基于阈值电压变化的优化方法来降低故障功率。使用算法创建无故障电路网表,同时仍然保持必要的延迟性能。使用这种方法可以减少6.14%的能源消耗。
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引用次数: 0
Identification of research gaps and systematization of trends on surface treatment in dental implants based on indexed data in the Scopus database 基于Scopus数据库的索引数据,确定牙种植体表面处理的研究差距和趋势的系统化
IF 1.1 4区 农林科学 Q3 AGRICULTURE, DAIRY & ANIMAL SCIENCE Pub Date : 2023-06-29 DOI: 10.14295/bjs.v2i12.437
Talita Rodrigues de Almeida, Rubens Guimarães Filho
The installation of dental implants brings significant improvements in patient's quality of life, causing the demand for these procedures to increase. This growth results from the increasing use of innovative technologies in oral care. Since the 1970s, dental implants have continuously evolved, both in terms of shape and surface treatments. This evolution aims to improve osseointegration, an essential process for implant success, and prevent complications such as peri-implantitis. A necessary part of this evolutionary process is surface treatment on dental implants. This treatment improves implant surfaces' physical and chemical properties, promoting a more efficient interaction between the implant and surrounding tissues. To achieve this goal, modifications are made to the texture, composition, and characteristics of the implant surface. In this context, this study aims to identify the research gaps related to surface treatment on dental implants. To this end, a literature review was performed in the Scopus database using specific search terms related to this topic. The 20 most cited articles from 2017 to 2023, which address the main research trends in this area, were selected for analysis. The theoretical contribution of this study is to systematize the current research trends on the surface treatment of dental implants. This provides a better understanding of existing treatments and their limitations and presents ongoing studies that aim to overcome them. Furthermore, the research highlights studies under development, both in vitro and in vivo, that seek to apply scientific advances in clinical practice to improve implant outcomes. This applied contribution is relevant, as it can positively impact clinical practice and benefit patients.
种植牙的安装给患者的生活质量带来了显著的改善,导致对这些手术的需求增加。这种增长是由于在口腔护理中越来越多地使用创新技术。自20世纪70年代以来,牙种植体在形状和表面处理方面不断发展。这种进化旨在改善骨整合,这是种植体成功的重要过程,并预防并发症,如种植体周围炎。这一进化过程的一个必要部分是牙种植体的表面处理。这种处理改善了种植体表面的物理和化学性质,促进了种植体与周围组织之间更有效的相互作用。为了实现这一目标,对植入体表面的纹理、组成和特性进行修改。在此背景下,本研究旨在确定与种植体表面处理相关的研究空白。为此,我们使用与该主题相关的特定搜索词在Scopus数据库中进行了文献综述。选取2017年至2023年被引用次数最多的20篇文章进行分析,这些文章阐述了该领域的主要研究趋势。本研究的理论贡献是将目前种植体表面处理的研究趋势系统化。这提供了对现有治疗方法及其局限性的更好理解,并提出了旨在克服它们的正在进行的研究。此外,该研究还强调了正在进行的体外和体内研究,这些研究试图将科学进步应用于临床实践,以改善植入物的效果。这种应用贡献是相关的,因为它可以积极影响临床实践并使患者受益。
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引用次数: 0
Phosphate solubilizing microorganisms in organomineral fertilizers to increase the productivity of Vigna unguiculata (L.) Walp. 有机肥中增磷微生物提高马蹄铁产量的研究Walp。
IF 1.1 4区 农林科学 Q3 AGRICULTURE, DAIRY & ANIMAL SCIENCE Pub Date : 2023-06-28 DOI: 10.14295/bjs.v2i12.379
M. V. A. Ventura, E. M. Costa, L. S. Pereira, Rodrigo Braghiroli, Hellen Regina Fernandes Batista-Ventura, E. Souchie
This work aimed to evaluate the interaction between P-solubilizing microorganisms and organomineral fertilizers in order to increase the cowpea nutrition and yield under field conditions. One field trial was carried out in a randomized complete block design arranged in subdivided plots (7 x 3) with four replicates. The organominerals (poultry litter, swine manure, filter cake and soot from chimneys) as well as triple superphosphate (TSP) with and without sulfur and the control treatment (no fertilizer addition), were considered the primary factor. The secondary factor was constituted by inoculation of Bradyrhizobium sp. SEMIA 6462 (Simbiose Nod Caupi®), one P-solubilizing bacteria (MBSF2) as well as no inoculation treatment. The MBSF2 inoculation combined to the soot organomineral increased the shoot length at 50 DAE. The stem diameter, shoot and root dry matter at 50 DAE were increased by Bradyrhizobium spp. inoculation and poultry litter. Also, the stem diameter was increased using filter cake organomineral and both inoculants. The nodules number was also increased by use of that organomineral combined to Bradyrhizobium spp.
本研究旨在探讨溶磷微生物与有机肥的相互作用,以期在田间条件下提高豇豆的营养和产量。1个田间试验采用随机完全区组设计,按细分样地(7 × 3)进行,共4个重复。有机矿物(禽畜粪便、猪粪、滤饼和烟囱烟尘)、含硫和不含硫的三元过磷酸酯(TSP)以及对照处理(不添加肥料)被认为是主要影响因素。次要因子为接种缓生根瘤菌SEMIA 6462 (Simbiose Nod Caupi®)和一种p溶菌(MBSF2),不接种处理。在50 DAE时,接种MBSF2与烟灰有机化合物结合可使苗长增加。接种缓生根瘤菌和家禽凋落物均可增加50 DAE时的茎粗、茎部和根干物质。同时,添加滤饼有机化合物和两种接种剂均可增加茎粗。该有机肥与缓生根瘤菌配伍后,根瘤数也增加。
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引用次数: 0
Agricultural fungicidal effect of floral extracts of Bauhinia variegata, B. forficata and B. purpurea 紫荆、紫荆和紫荆花提取物的农业杀真菌效果
IF 1.1 4区 农林科学 Q3 AGRICULTURE, DAIRY & ANIMAL SCIENCE Pub Date : 2023-06-25 DOI: 10.14295/bjs.v2i12.392
Charles Henrique de Marques Lima, Porshia Sharma, M. V. A. Ventura, A. C. P. M. Menezes Filho, C. F. S. Castro, Elizabete Nunes da Rocha
Bauhinia is a botanical genus widely distributed in parts of Asia and South America. The plant bears beautiful and aromatic flowers that add ornamental beauty to parks and gardens, in addition to being used in medicine and ayurverda. This study aimed to evaluate the floral ethanolic extract of B. variegata, B. forficata and B. purpurea in fungal inhibition against Sclerotinia sclerotiorum, Colletotrichum gloeosporioides and Colletotrichum acutatum. Flowers were harvested in 2021 and 2022. The floral ethanolic extract was produced by the static maceration method. The antifungal activity was performed by the agar diffusion method at different extract s;concentrations. Bauhinia floral extracts showed a potential fungicidal effect on fungal species evaluated in particular for Sclerotinia sclerotiorum, followed by Colletotrichum gloeosporioides and Colletotrichum acutatum.
紫荆花是一个广泛分布于亚洲和南美洲部分地区的植物属。这种植物长着美丽芳香的花朵,除了用于医药和印度草药之外,还为公园和花园增添了装饰性。摘要本研究旨在评价花青花、forficata花和purpurea花乙醇提取物对菌核菌、gloeosporioides炭疽菌和actuatum炭疽菌的抑菌作用。花在2021年和2022年收获。采用静态浸渍法制备花乙醇提取物。采用琼脂扩散法测定不同浓度提取物的抑菌活性。紫荆花提取物对菌核菌(Sclerotinia sclerotiorum)、gloeosporioides和actuatum炭疽菌(Colletotrichum acutatum)具有潜在的杀真菌作用。
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引用次数: 0
Hospitality management program evaluations: Bases for curriculum enhancement 酒店管理课程评估:课程改进的基础
IF 1.1 4区 农林科学 Q3 AGRICULTURE, DAIRY & ANIMAL SCIENCE Pub Date : 2023-06-24 DOI: 10.14295/bjs.v2i12.386
Leahlou E. Narvios, Hubert Quiñones, F. Gabuya
Global standards in Hospitality Management in terms of academic learning and practical skills are very stiff competition in the industry. Interns' level of performance due to the individual KSA (Knowledge, Skill, and Attitude) evaluation CTU-Main HM collected. However, the internship performance of the Trainee depends individually in terms of KSA. A quantitative method structured questionnaire and distributed to evaluate how the individual factors of interns that would help determine the curriculum enhancement based on the results. Essential insights that advance understanding of the efficient design and informed management of internship programs based on evaluations among students can be invaluable in measuring outcomes from the internship program and the entire professional instruction program for future Hospitality Management professionals. It provides perspectives on coursework, activities, and suggested curriculum changes. Integrating program and internship assessment is appropriate since internships are part of the program. It attempted to explore the academic performance and internship performance in terms of KSA and personality of hospitality management students by examining their capacity before the internship and their skills enhancement needed for the internship experience following its completion. It reveals that an interaction that influence the individual factors is essential in shaping student expectations of the internship. Individual and organizational factors regarded as influencers on interns' experience, training factors about the transition of environment that regulate interns' experience and characteristics serve as mediators to the internship experience.
酒店管理在学术学习和实践技能方面的全球标准是非常激烈的行业竞争。根据CTU-Main HM收集的个人KSA(知识、技能和态度)评估,实习生的表现水平。然而,实习生的实习表现取决于个人的KSA。采用定量方法编制问卷并分发,以评估实习生的个人因素如何有助于根据结果确定课程的改进。在学生评估的基础上,对实习项目的有效设计和知情管理进行深入了解,这些基本见解对于衡量实习项目和未来酒店管理专业人员的整个专业指导项目的成果是非常宝贵的。它提供了对课程作业、活动和建议的课程改革的观点。由于实习是项目的一部分,因此整合项目和实习评估是合适的。它试图通过考察酒店管理专业学生实习前的能力和实习结束后实习经验所需的技能提高,来探讨他们在KSA和个性方面的学习成绩和实习表现。它揭示了影响个体因素的相互作用在塑造学生对实习的期望中是必不可少的。个体因素和组织因素是实习生体验的影响因素,调节实习生体验的环境转变的培训因素和实习生特征是实习生体验的中介因素。
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引用次数: 0
Pollen quality assessment of Tetragonisca angustula, Melipona quadrifasciata and Apis mellifera 大角田鼠、四趾田鼠和蜜蜂花粉质量评价
IF 1.1 4区 农林科学 Q3 AGRICULTURE, DAIRY & ANIMAL SCIENCE Pub Date : 2023-06-24 DOI: 10.14295/bjs.v2i12.389
Auriane Nascimento Barroso, A. C. P. M. Menezes Filho, Aparecida Sofia Taques, M. V. A. Ventura
Pollen is a product originating from the anthers of flowers. Members of the Apidae group feed on this floristic product, which is metabolized and stored in the hives. It is known that the pollen metabolized by stingless and stingless bees has medicinal and nutritional characteristics. This study aimed to evaluate the physicochemical and microbiological quality of pollen collected by Tetragonisca angustula, Melipona quadrifasciata and Apis mellifera. Pollen was collected between January 2021 and January 2023 in a conservation area in Goiás, Brazil. The pollen was characterized by physicalchemical analysis for moisture, ash, proteins, lipids, total sugars and pH, and microbiological analysis on Escherichia coli and Salmonella spp. The obtained results characterize the pollens of indigenous bees as suitable for consumption, since they presented good physicochemical characteristics for most of the analyzed parameters and free of pathogens.
花粉是源自花的花药的产物。蜜蜂科的成员以这种植物产品为食,这些产品被代谢并储存在蜂箱中。已知无刺蜂和无刺蜂代谢的花粉具有药用和营养特性。本研究旨在评价四角鼠、四趾鼠和蜜蜂采集的花粉的理化和微生物品质。花粉于2021年1月至2023年1月在巴西Goiás的一个保护区收集。对土蜂花粉进行了水分、灰分、蛋白质、脂质、总糖和pH等理化分析,并对大肠杆菌和沙门氏菌进行了微生物学分析,结果表明土蜂花粉具有良好的理化特性,且不含致病菌,适合食用。
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引用次数: 0
Agricultural fungicidal effect of Tetragonisca angustula Latreille, 1811 propolis extract 1811蜂胶提取物的农业杀菌剂作用
IF 1.1 4区 农林科学 Q3 AGRICULTURE, DAIRY & ANIMAL SCIENCE Pub Date : 2023-06-21 DOI: 10.14295/bjs.v2i11.411
Lucas Pereira Macedo, A. C. P. M. Menezes Filho, C. F. S. Castro, M. V. A. Ventura
Propolis is a resinous product rich in phenolic compounds and flavonoids produced by bees. This study aimed to evaluate the propolis of Tetragonisca angustula regarding its classification group, ultraviolet and visible spectroscopy (UV-Vis) and its antifungal biological activity against Sclerotinia sclerotiorum, Colletotrichum gloeosporioides and Colletotrichum acutatum phytopathogens of grains and fruits of interest commercial. Propolis was collected from T. angustula hives in a permanent preservation area. The ethanolic extract was produced by static maceration. The classification group according to the dermal color, the determination of the bands were obtained in a UV-Vis spectrophotometer between 450-800 nm, the antifungal activity carried out in in vitro PDA medium at different concentrations on S. sclerotiorum, C. gloeosporioides and C. acutatum and expressed as a percentage (%). The group in which T. angustula propolis extract fits is the 12 SP12 group, UV-Vis bands identified the presence of flavonoids and phenolic compounds and the antifungal activity demonstrated that S. sclerotiorum is more sensitive when comparing the two species Colletotrichum fungi evaluated.
蜂胶是一种富含酚类化合物和类黄酮的树脂产品,由蜜蜂生产。本研究旨在从分类类群、紫外-可见光谱(UV-Vis)、抗菌核菌(Sclerotinia sclerotiorum)、炭疽菌(Colletotrichum gloeosporioides)和尖锐炭疽菌(Colletotrichum acutatum)的生物活性等方面进行评价。蜂胶是在永久保存区内采集的。采用静态浸渍法制备乙醇提取物。根据皮肤颜色进行分类,紫外可见分光光度计在450 ~ 800 nm范围内测定,在不同浓度的PDA体外培养基中对菌丝体、gloeosporioides和acutatum的抑菌活性均以百分比(%)表示。蜂胶提取物适用于12 SP12组,紫外-可见光谱鉴定出黄酮类化合物和酚类化合物的存在,抗真菌活性表明S. sclerotiorum对两种炭黑菌更敏感。
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引用次数: 1
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Brazilian Journal of Poultry Science
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