BACKGROUNDPerioperative myocardial injury has often been attributed to type 2 myocardial infarction, but acute systemic inflammation could also contribute. We examined the role of systemic inflammation in myocardial injury after abdominal surgery using a murine model.METHODSMale C57BL/6 mice underwent standardised abdominal surgery or anaesthesia alone. Myocardial injury (serum cardiac troponin I [cTnI]) and systemic inflammation (serum interleukin-6 [IL-6]) were quantified (enzyme-linked immunoassay) at 1 h to 7 days after surgery with anaesthesia or anaesthesia alone. Transcriptomic changes in myocardial tissue were analysed by RNA sequencing, with protein level confirmation by immuno blotting and immunostaining. Data are presented as mean (sd).RESULTSSurgery induced an early elevation in cTnI, peaking at 277.8 (69.0) pg ml-1 within 3 h after surgery, compared with 6.8 (1.6) pg ml-1 in anaesthesia-only controls (P<0.001). Higher cTnI levels were paralleled by serum IL-6 peaking at 3 h. Perioperative heart rate was similar between each group. RNA sequencing of myocardial tissue showed an acute inflammatory-stress response, with marked upregulated transcription of members of the pro-inflammatory S100 calcium-binding protein family, S100A8 and S100A9. Protein expression of S100A9 was predominantly increased in cardiac macrophages after surgery. Pharmacological inhibition of S100A8/A9 with the potent S100A8/A9 antagonist ABR-238901 (30 mg kg-1, i.p.) administered 60 min before surgery, reduced myocardial injury as indicated by lower cTnI 3 h after surgery. ABR-238901 had no effect on circulating IL-6 levels.CONCLUSIONSMyocardial injury after abdominal surgery in mice involves a local, macrophage-mediated inflammatory response, the inhibition of which reduces postoperative cTnI elevation.
{"title":"Myocardial injury mediated by acute inflammation after abdominal surgery in mice: mechanistic translational laboratory study.","authors":"Makishi Maeda,Yusuke Yoshikawa,Sho Ohno,Yasuaki Sawashita,Koki Nakamura,Masatoshi Kanda,Naoyuki Hirata,Michiaki Yamakage","doi":"10.1016/j.bja.2025.12.028","DOIUrl":"https://doi.org/10.1016/j.bja.2025.12.028","url":null,"abstract":"BACKGROUNDPerioperative myocardial injury has often been attributed to type 2 myocardial infarction, but acute systemic inflammation could also contribute. We examined the role of systemic inflammation in myocardial injury after abdominal surgery using a murine model.METHODSMale C57BL/6 mice underwent standardised abdominal surgery or anaesthesia alone. Myocardial injury (serum cardiac troponin I [cTnI]) and systemic inflammation (serum interleukin-6 [IL-6]) were quantified (enzyme-linked immunoassay) at 1 h to 7 days after surgery with anaesthesia or anaesthesia alone. Transcriptomic changes in myocardial tissue were analysed by RNA sequencing, with protein level confirmation by immuno blotting and immunostaining. Data are presented as mean (sd).RESULTSSurgery induced an early elevation in cTnI, peaking at 277.8 (69.0) pg ml-1 within 3 h after surgery, compared with 6.8 (1.6) pg ml-1 in anaesthesia-only controls (P<0.001). Higher cTnI levels were paralleled by serum IL-6 peaking at 3 h. Perioperative heart rate was similar between each group. RNA sequencing of myocardial tissue showed an acute inflammatory-stress response, with marked upregulated transcription of members of the pro-inflammatory S100 calcium-binding protein family, S100A8 and S100A9. Protein expression of S100A9 was predominantly increased in cardiac macrophages after surgery. Pharmacological inhibition of S100A8/A9 with the potent S100A8/A9 antagonist ABR-238901 (30 mg kg-1, i.p.) administered 60 min before surgery, reduced myocardial injury as indicated by lower cTnI 3 h after surgery. ABR-238901 had no effect on circulating IL-6 levels.CONCLUSIONSMyocardial injury after abdominal surgery in mice involves a local, macrophage-mediated inflammatory response, the inhibition of which reduces postoperative cTnI elevation.","PeriodicalId":9250,"journal":{"name":"British journal of anaesthesia","volume":"39 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2026-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146042486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-23DOI: 10.1016/j.bja.2025.12.022
David L. Hepner, Adriana D. Oprea, Bobbie Jean Sweitzer
{"title":"Perioperative management of patients taking glucagon-like peptide-1 receptor agonists: implementation of complex fasting recommendations. Response to Br J Anaesth 2025; 136: 375-6","authors":"David L. Hepner, Adriana D. Oprea, Bobbie Jean Sweitzer","doi":"10.1016/j.bja.2025.12.022","DOIUrl":"https://doi.org/10.1016/j.bja.2025.12.022","url":null,"abstract":"","PeriodicalId":9250,"journal":{"name":"British journal of anaesthesia","volume":"43 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2026-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146032855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-23DOI: 10.1016/j.bja.2025.12.049
Anna Maria Bombardieri,Miles Berger,Kristin Schreiber
{"title":"Effect of perioperative autonomic nervous system imbalance on surgical outcomes: role of regional sympathetic block. Comment on Br J Anaesth 2025; 135: 608-22.","authors":"Anna Maria Bombardieri,Miles Berger,Kristin Schreiber","doi":"10.1016/j.bja.2025.12.049","DOIUrl":"https://doi.org/10.1016/j.bja.2025.12.049","url":null,"abstract":"","PeriodicalId":9250,"journal":{"name":"British journal of anaesthesia","volume":"117 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2026-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146042459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-23DOI: 10.1016/j.bja.2025.12.017
Alexandra Bolger,Katie Smith,Benjamin J Blaise
{"title":"Driving change in fasting guidelines in a risk-averse environment: survey of current UK approaches and the infant milk fasting initiative.","authors":"Alexandra Bolger,Katie Smith,Benjamin J Blaise","doi":"10.1016/j.bja.2025.12.017","DOIUrl":"https://doi.org/10.1016/j.bja.2025.12.017","url":null,"abstract":"","PeriodicalId":9250,"journal":{"name":"British journal of anaesthesia","volume":"13 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2026-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146042458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-22DOI: 10.1016/j.bja.2026.01.001
Tomas Janulevicius, Nick Barrett
{"title":"Effect of blue operating theatre lighting on the recognition of colour-coded anaesthesia drug labels","authors":"Tomas Janulevicius, Nick Barrett","doi":"10.1016/j.bja.2026.01.001","DOIUrl":"https://doi.org/10.1016/j.bja.2026.01.001","url":null,"abstract":"","PeriodicalId":9250,"journal":{"name":"British journal of anaesthesia","volume":"49 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2026-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146032862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-22DOI: 10.1016/j.bja.2025.12.008
Marla B. Ferschl, Sarah Chen, Sophia Collis, Adam Jacobson, Kerstin Kolodzie
{"title":"Association between preoperative tropospheric ozone exposure and adverse perioperative respiratory events in paediatric patients: a single-centre retrospective cohort study","authors":"Marla B. Ferschl, Sarah Chen, Sophia Collis, Adam Jacobson, Kerstin Kolodzie","doi":"10.1016/j.bja.2025.12.008","DOIUrl":"https://doi.org/10.1016/j.bja.2025.12.008","url":null,"abstract":"","PeriodicalId":9250,"journal":{"name":"British journal of anaesthesia","volume":"16 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2026-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146032858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-22DOI: 10.1016/j.bja.2025.12.031
Francisco Reinoso-Barbero, Laura Lopez-Garcia, Mercedes Prieto-Alonso, Pascual Sanabria-Carretero
{"title":"Impact of desflurane removal from the operating room on carbon dioxide emissions at a tertiary academic medical centre: potential impact on anaesthesia time. Comment on Br J Anaesth 2025; 135: 1635–44","authors":"Francisco Reinoso-Barbero, Laura Lopez-Garcia, Mercedes Prieto-Alonso, Pascual Sanabria-Carretero","doi":"10.1016/j.bja.2025.12.031","DOIUrl":"https://doi.org/10.1016/j.bja.2025.12.031","url":null,"abstract":"","PeriodicalId":9250,"journal":{"name":"British journal of anaesthesia","volume":"69 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2026-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146032861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：