Pub Date : 2021-10-20DOI: 10.29117/quarfe.2021.0159
Mutaz Oshi, Emad AbuShanab
Unmanaged project risks can jeopardize the project's success and outcome. To assist project managers in overcoming or reducing the impact of project risk, several risk management models and standards have been established. This study is aimed to assess the impact of identified IT project risk factors on project delivery (satisfaction) in Qatar’s public sector. A questionnaire consisting of identified risk factors was developed by reviewing related literature. Data were collected from the target sample and analyzed using SPSS and SmartPLS. The results demonstrated the impact of each of the nine identified risk factors with the dependent variable project delivery (satisfaction). The hypotheses analysis showed five hypotheses H1, H2, H5, H6, and H8 supporting the literature with a positive impact on project delivery (satisfaction). Those factors are namely, the Stakeholders, Business Process, Organizational, Technical, and Schedule with significant P-values of 0.030, 0.002, 0.028, 0.023, and 0.001, respectively. The other four hypotheses H3, H4, H7, and H9 are inconsistent with the literature, with (insignificant) high P-values resulting in a negative impact on project delivery (satisfaction). Those factors are namely, Project Management, Human resources, Budget, and External with P-values 0.164, 0.605, 0.096, 0.225, respectively. The researcher recommends that project management professionals consider the five identified risk factors with a positive impact as the most critical IT risk factors; the research findings serve as a foundation and guideline to help the project management community avoid project pitfalls commonly associated with poor risk management and project failure.
{"title":"The impact of Risk Identification on IT Project Delivery in Qatar Public Sector","authors":"Mutaz Oshi, Emad AbuShanab","doi":"10.29117/quarfe.2021.0159","DOIUrl":"https://doi.org/10.29117/quarfe.2021.0159","url":null,"abstract":"Unmanaged project risks can jeopardize the project's success and outcome. To assist project managers in overcoming or reducing the impact of project risk, several risk management models and standards have been established. This study is aimed to assess the impact of identified IT project risk factors on project delivery (satisfaction) in Qatar’s public sector. A questionnaire consisting of identified risk factors was developed by reviewing related literature. Data were collected from the target sample and analyzed using SPSS and SmartPLS. The results demonstrated the impact of each of the nine identified risk factors with the dependent variable project delivery (satisfaction). The hypotheses analysis showed five hypotheses H1, H2, H5, H6, and H8 supporting the literature with a positive impact on project delivery (satisfaction). Those factors are namely, the Stakeholders, Business Process, Organizational, Technical, and Schedule with significant P-values of 0.030, 0.002, 0.028, 0.023, and 0.001, respectively. The other four hypotheses H3, H4, H7, and H9 are inconsistent with the literature, with (insignificant) high P-values resulting in a negative impact on project delivery (satisfaction). Those factors are namely, Project Management, Human resources, Budget, and External with P-values 0.164, 0.605, 0.096, 0.225, respectively. The researcher recommends that project management professionals consider the five identified risk factors with a positive impact as the most critical IT risk factors; the research findings serve as a foundation and guideline to help the project management community avoid project pitfalls commonly associated with poor risk management and project failure.","PeriodicalId":9295,"journal":{"name":"Building Resilience at Universities: Role of Innovation and Entrepreneurship","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87599819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-20DOI: 10.29117/quarfe.2021.0157
Q. Hussain, Wael K. M. Alhajyaseen, Mohamed Kharbeche
Pedestrians are the most vulnerable group in the traffic. Every year approximately 40,000 pedestrians are killed in the world due to road traffic crashes. In the state of Qatar, the situations are even worse with around one-third of the total road traffic deaths coming from pedestrians. The main aim of this driving simulator study was to investigate the impact of different measures on driving behavior. To this end, five different treatments were tested and compared with the untreated condition. The treatment conditions included two detection-based measures (i.e., Variable Message Sign VMS and LED), two different road-marking conditions (i.e., Zigzag marking and road narrowing marking) and a physical road narrowing condition. Each condition was tested with a yield/stop controlled marked crosswalk for two situations. In the first situation (Situation PA) there was no pedestrian at the crosswalk, while the second situation was based on the presence of a pedestrian (Situation PP). The experiment was conducted using the driving simulator at Qatar University. Sixty-one volunteers possessing a valid Qatari driving license participated in the study. The collected data was analyzed for drivers’ yielding rates, vehicle-pedestrian interactions, and driving speed. The results showed that the three conditions, i.e., VMS, Narrowing and Physical were effective in improving drivers’ yielding rate up to 98.2%. In addition, we found that all the treatment conditions were effective in reducing drivers’ travel speed in Situation PP. Nevertheless, in the situation with no pedestrian present, the physical road narrowing outperformed the other conditions in terms of reducing travel speed. Taking into account the results from this study, we recommend Physical condition as a potentially effective and low-cost treatment for improving safety at yield/stop controlled crosswalks.
{"title":"Enhancing Pedestrian Safety through the Development of Advanced Operational Strategies for Crosswalks in Residential Areas","authors":"Q. Hussain, Wael K. M. Alhajyaseen, Mohamed Kharbeche","doi":"10.29117/quarfe.2021.0157","DOIUrl":"https://doi.org/10.29117/quarfe.2021.0157","url":null,"abstract":"Pedestrians are the most vulnerable group in the traffic. Every year approximately 40,000 pedestrians are killed in the world due to road traffic crashes. In the state of Qatar, the situations are even worse with around one-third of the total road traffic deaths coming from pedestrians. The main aim of this driving simulator study was to investigate the impact of different measures on driving behavior. To this end, five different treatments were tested and compared with the untreated condition. The treatment conditions included two detection-based measures (i.e., Variable Message Sign VMS and LED), two different road-marking conditions (i.e., Zigzag marking and road narrowing marking) and a physical road narrowing condition. Each condition was tested with a yield/stop controlled marked crosswalk for two situations. In the first situation (Situation PA) there was no pedestrian at the crosswalk, while the second situation was based on the presence of a pedestrian (Situation PP). The experiment was conducted using the driving simulator at Qatar University. Sixty-one volunteers possessing a valid Qatari driving license participated in the study. The collected data was analyzed for drivers’ yielding rates, vehicle-pedestrian interactions, and driving speed. The results showed that the three conditions, i.e., VMS, Narrowing and Physical were effective in improving drivers’ yielding rate up to 98.2%. In addition, we found that all the treatment conditions were effective in reducing drivers’ travel speed in Situation PP. Nevertheless, in the situation with no pedestrian present, the physical road narrowing outperformed the other conditions in terms of reducing travel speed. Taking into account the results from this study, we recommend Physical condition as a potentially effective and low-cost treatment for improving safety at yield/stop controlled crosswalks.","PeriodicalId":9295,"journal":{"name":"Building Resilience at Universities: Role of Innovation and Entrepreneurship","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87739172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-20DOI: 10.29117/quarfe.2021.0202
S. Al-Thani, Lolwa Al-Mohannadi, Meera Al-Khulifi, Doha Elsaman, Mark David, H. Osama
The BCR Corridors at QU are notorious for wayfinding difficulties of end-users in the building complex. These navigation problems appear to arise due to the repetitive similarity of individual parts in its modular design, highly localized impediments to readability and visibility such as shading device screens and temporary installations, and the relationship of those different parts composing the collective whole of the BCR Corridors to the immediate surrounding context of the QU campus (Figure 1). The purpose of the “Complexity and Use in Building Evaluation” research project (CUBE2: QUST-2-CENG-2019-12) is to build on the research success of the post-occupancy cluster in the first demonstration project (CUBE1: QUST-2-CENG-2018-9). It includes continuing to develop a detailed post-occupancy dataset of movement and space use in buildings at QU. The goal is to contribute positively to future design refinements, alterations, and design of new university buildings at QU. We want to help create a world-class center of education and research where space use, interaction, and innovation are tactically ‘woven’ into the design and planning of the campus at various scales of the built environment. In the CUBE1 study, Major et al. (2019) were able to graphically illustrate building program/use and movement/space use patterns. It included quantifying the relationship between movement and spatial layout, and the significance of other end-user activities such as sitting and interacting in the common areas of the QU Women’s Engineering Building. It also included identifying adaptive re-use of classrooms and storage spaces for laboratory and office uses, leading to a shortage of storage spaces in the building. There was a consistent relationship (R^2=0.68, p < 0.001) between sitting and interacting unrelated to accessibility or metric area, i.e., the availability of seating was the dominant factor for casual encounter, mostly of students. Finally, there was a weak but consistent relationship (R^2=0.38, p < 0.001) between spatial layout and movement flows using space syntax modeling when allowing for the strongly programmatic differences (classrooms versus faculty offices) in different wings of the building (Major et al., 2019) (Figure 2). The post-occupancy evaluation findings in the CUBE1 project were largely consistent with previous results of space syntax research over the last 30 years for generative layouts such as office buildings, colleges, and research laboratories. Those results include the generative role of spatial layout for movement and casual encounter in buildings, the prescriptive effects of strong programmatic aspects (in this case, classroom location and course schedules) in causing some spaces to over-perform/underperform for some types of uses, most usually movement, and the singular importance for the provision of seating to facilitate consistent and robust use of spaces whether at the building or urban level (Hillier and Penn, 1991; Hilli
位于中区的BCR走廊，对大楼内的最终使用者来说，找路困难是出了名的。这些导航问题似乎是由于其模块化设计中单个部分的重复相似性，高度本地化的可读性和可视性障碍，如遮光设备屏幕和临时安装，以及组成BCR走廊集体整体的不同部分与QU校园周围环境的关系(图1)。在首个示范项目(CUBE1: QUST-2-CENG-2018-9)入驻后集群研究成功的基础上，开展QUST-2-CENG-2019-12研究。它包括继续开发一个详细的占用后建筑运动和空间使用数据集。目标是为QU未来的设计改进、改造和新大学建筑的设计做出积极贡献。我们希望帮助创建一个世界级的教育和研究中心，在这个中心，空间使用、互动和创新在不同规模的建筑环境中策略性地“编织”到校园的设计和规划中。在CUBE1研究中，Major等人(2019)能够图形化地说明建筑程序/使用和运动/空间使用模式。它包括量化运动和空间布局之间的关系，以及其他终端用户活动的重要性，例如在曲区妇女工程大楼的公共区域坐着和互动。它还包括确定实验室和办公室使用的教室和存储空间的适应性再利用，导致建筑中存储空间的短缺。与可达性或度量面积无关的座位和互动之间存在一致的关系(R^2=0.68, p < 0.001)，即座位的可用性是偶然相遇的主要因素，大多数是学生。最后，当考虑到建筑不同侧翼的强烈程序性差异(教室与教师办公室)时，空间布局和使用空间语法建模的运动流之间存在微弱但一致的关系(R^2=0.38, p < 0.001)。CUBE1项目的使用后评估结果与过去30年对办公楼、大学和研究实验室等生成式布局的空间句法研究结果基本一致。这些结果包括空间布局对建筑中运动和偶然相遇的生成作用，强大的程序性方面(在这种情况下，教室位置和课程安排)的规定作用，导致一些空间在某些类型的用途中表现过度/表现不佳，最常见的是运动，以及提供座位以促进建筑物或城市层面上空间的一致和强大使用的单一重要性(Hillier和Penn, 1991;希利尔,1996;Hillier et al.， 1996;Major等人，2019;Sailer et al.， 2016)。
{"title":"Complexity and Use in Building Evaluation (CUBE2): The Modular Case of the BCR Corridors at Qatar University","authors":"S. Al-Thani, Lolwa Al-Mohannadi, Meera Al-Khulifi, Doha Elsaman, Mark David, H. Osama","doi":"10.29117/quarfe.2021.0202","DOIUrl":"https://doi.org/10.29117/quarfe.2021.0202","url":null,"abstract":"The BCR Corridors at QU are notorious for wayfinding difficulties of end-users in the building complex. These navigation problems appear to arise due to the repetitive similarity of individual parts in its modular design, highly localized impediments to readability and visibility such as shading device screens and temporary installations, and the relationship of those different parts composing the collective whole of the BCR Corridors to the immediate surrounding context of the QU campus (Figure 1). The purpose of the “Complexity and Use in Building Evaluation” research project (CUBE2: QUST-2-CENG-2019-12) is to build on the research success of the post-occupancy cluster in the first demonstration project (CUBE1: QUST-2-CENG-2018-9). It includes continuing to develop a detailed post-occupancy dataset of movement and space use in buildings at QU. The goal is to contribute positively to future design refinements, alterations, and design of new university buildings at QU. We want to help create a world-class center of education and research where space use, interaction, and innovation are tactically ‘woven’ into the design and planning of the campus at various scales of the built environment. In the CUBE1 study, Major et al. (2019) were able to graphically illustrate building program/use and movement/space use patterns. It included quantifying the relationship between movement and spatial layout, and the significance of other end-user activities such as sitting and interacting in the common areas of the QU Women’s Engineering Building. It also included identifying adaptive re-use of classrooms and storage spaces for laboratory and office uses, leading to a shortage of storage spaces in the building. There was a consistent relationship (R^2=0.68, p < 0.001) between sitting and interacting unrelated to accessibility or metric area, i.e., the availability of seating was the dominant factor for casual encounter, mostly of students. Finally, there was a weak but consistent relationship (R^2=0.38, p < 0.001) between spatial layout and movement flows using space syntax modeling when allowing for the strongly programmatic differences (classrooms versus faculty offices) in different wings of the building (Major et al., 2019) (Figure 2). The post-occupancy evaluation findings in the CUBE1 project were largely consistent with previous results of space syntax research over the last 30 years for generative layouts such as office buildings, colleges, and research laboratories. Those results include the generative role of spatial layout for movement and casual encounter in buildings, the prescriptive effects of strong programmatic aspects (in this case, classroom location and course schedules) in causing some spaces to over-perform/underperform for some types of uses, most usually movement, and the singular importance for the provision of seating to facilitate consistent and robust use of spaces whether at the building or urban level (Hillier and Penn, 1991; Hilli","PeriodicalId":9295,"journal":{"name":"Building Resilience at Universities: Role of Innovation and Entrepreneurship","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86144952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-20DOI: 10.29117/quarfe.2021.0088
H. Yalcin, Hissa F. Al-Thani, S. Shurbaji
Tyrosine kinase inhibitors (TKIs) are new generation of anti-cancer drugs with very high efficiency against cancer cells. However, TKIs are associated with severe cardiotoxicity limiting their clinical benefits. One TKI that has been developed recently but not explored much is Ponatinib. The use of nanoparticles as a better therapeutic agent to deliver anti-cancer drugs and reduce their cardiotoxicity has been recently considered. In this study, PLGA-PEG-PLGA nanoparticles were synthesized to deliver Ponatinib while reducing its cardiotoxicity for treatment of chronic myeloid leukemia. Shape, size, surface charge and drug uptake ability of these nanoparticles were assessed using transmission electron microscopy (TEM), ZetaSIZER NANO and high-performance liquid chromatography (HPLC). Cardiotoxicity of Ponatinib, unloaded and loaded PLGA-PEG-PLGA nanoparticles were studied on zebrafish model through measuring the survival rate and cardiac function parameters, to optimize efficient drug concentrations in an in vivo setting. These particles were tested on zebrafish cancer xenograft model in which, K562 cell line, was transplanted into zebrafish embryos. We showed that, at an optimal concentration (0.0025mg/ml), Ponatinib loaded PLGA-PEG-PLGA particles are non-toxic/non-cardio-toxic and are very efficient against cancer growth and metastasis. Zebrafish is a good animal model for investigating the cardiotoxicity associated with the anti-cancer drugs such as TKIs, to determine the optimum concentration of smart nanoparticles with the least side effects and to generate xenograft model of several cancer types. Also, PLGA-PEG-PLGA NPs could be good candidate for CML treatment, but their cellular internalization should be enhanced. This could be achieved by coating and labeling the surface of PLGA-PEG-PLGA NPs with specific ligands that are unique to CML cells.
{"title":"Development and In Vivo Testing of Smart Nanoparticles for Enhanced Anti-Cancer Activity and Reduced Cardiotoxicity Associated with Tyrosine Kinase Inhibitors","authors":"H. Yalcin, Hissa F. Al-Thani, S. Shurbaji","doi":"10.29117/quarfe.2021.0088","DOIUrl":"https://doi.org/10.29117/quarfe.2021.0088","url":null,"abstract":"Tyrosine kinase inhibitors (TKIs) are new generation of anti-cancer drugs with very high efficiency against cancer cells. However, TKIs are associated with severe cardiotoxicity limiting their clinical benefits. One TKI that has been developed recently but not explored much is Ponatinib. The use of nanoparticles as a better therapeutic agent to deliver anti-cancer drugs and reduce their cardiotoxicity has been recently considered. In this study, PLGA-PEG-PLGA nanoparticles were synthesized to deliver Ponatinib while reducing its cardiotoxicity for treatment of chronic myeloid leukemia. Shape, size, surface charge and drug uptake ability of these nanoparticles were assessed using transmission electron microscopy (TEM), ZetaSIZER NANO and high-performance liquid chromatography (HPLC). Cardiotoxicity of Ponatinib, unloaded and loaded PLGA-PEG-PLGA nanoparticles were studied on zebrafish model through measuring the survival rate and cardiac function parameters, to optimize efficient drug concentrations in an in vivo setting. These particles were tested on zebrafish cancer xenograft model in which, K562 cell line, was transplanted into zebrafish embryos. We showed that, at an optimal concentration (0.0025mg/ml), Ponatinib loaded PLGA-PEG-PLGA particles are non-toxic/non-cardio-toxic and are very efficient against cancer growth and metastasis. Zebrafish is a good animal model for investigating the cardiotoxicity associated with the anti-cancer drugs such as TKIs, to determine the optimum concentration of smart nanoparticles with the least side effects and to generate xenograft model of several cancer types. Also, PLGA-PEG-PLGA NPs could be good candidate for CML treatment, but their cellular internalization should be enhanced. This could be achieved by coating and labeling the surface of PLGA-PEG-PLGA NPs with specific ligands that are unique to CML cells.","PeriodicalId":9295,"journal":{"name":"Building Resilience at Universities: Role of Innovation and Entrepreneurship","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86224409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-20DOI: 10.29117/quarfe.2021.0187
Maryam Hussain Abal-Seqan, S. Pokharel, K. Naji
This thesis focuses on developing an understanding of factors that can help in increasing the project performance in Qatar and elsewhere. The understanding leads to focus on factors in the design, development and operation of the project. This research identifies 23 critical success factors in four different groups: top management support, project manager’s skills, project team’s skills, and stakeholder management knowledge. The work also identifies four main project success criteria: project delivery on time, within the budget, with the expected quality, and meeting stakeholder's satisfaction.
{"title":"Influence of Critical Success Factors over the Performance of Infrastructure Projects in Qatar","authors":"Maryam Hussain Abal-Seqan, S. Pokharel, K. Naji","doi":"10.29117/quarfe.2021.0187","DOIUrl":"https://doi.org/10.29117/quarfe.2021.0187","url":null,"abstract":"This thesis focuses on developing an understanding of factors that can help in increasing the project performance in Qatar and elsewhere. The understanding leads to focus on factors in the design, development and operation of the project. This research identifies 23 critical success factors in four different groups: top management support, project manager’s skills, project team’s skills, and stakeholder management knowledge. The work also identifies four main project success criteria: project delivery on time, within the budget, with the expected quality, and meeting stakeholder's satisfaction.","PeriodicalId":9295,"journal":{"name":"Building Resilience at Universities: Role of Innovation and Entrepreneurship","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82942614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-20DOI: 10.29117/quarfe.2021.0047
Thaer M. I. Syam, Asan Gani Bin Abdul Muthalif
Magnetorheological Elastomer (MRE) is a type of smart composite material consisting of a polymer matrix embedded with ferromagnetic particles. In the presence of an external magnetic field, its mechanical properties, such as stiffness, changes make it attractive in vibration isolation applications. Unwanted vibration in machines can cause severe damage and machine breakdown. In Qatar, the extraction of the natural gas from the ground requires sophisticated drilling machines. In this work, a semi-active vibration isolator using MRE is proposed for a potential application in a drilling system to isolate the torsional vibration. MRE was fabricated with a 35% mass fraction (MF) consisting of silicon rubber and iron particles. It was fitted with aluminum couplers and attached to the shaft (drill string) to study its efficiency in vibration isolation under a magnetic field. Two tests were conducted on the drilling prototype setup used in this work; the first test was a hammer impact test. The torsional transfer function TTF analysis showed that the system's natural frequency has shifted from 13.9 Hz to 17.5 Hz by the influence of increasing magnetic field around the MRE. The results showed that the continuous rotational vibration amplitude of the prototype is attenuated by more than 40%.
{"title":"Magnetorheological Elastomer (MRE) based Torsional Vibration Isolator for application in a Prototype Drilling Shaft","authors":"Thaer M. I. Syam, Asan Gani Bin Abdul Muthalif","doi":"10.29117/quarfe.2021.0047","DOIUrl":"https://doi.org/10.29117/quarfe.2021.0047","url":null,"abstract":"Magnetorheological Elastomer (MRE) is a type of smart composite material consisting of a polymer matrix embedded with ferromagnetic particles. In the presence of an external magnetic field, its mechanical properties, such as stiffness, changes make it attractive in vibration isolation applications. Unwanted vibration in machines can cause severe damage and machine breakdown. In Qatar, the extraction of the natural gas from the ground requires sophisticated drilling machines. In this work, a semi-active vibration isolator using MRE is proposed for a potential application in a drilling system to isolate the torsional vibration. MRE was fabricated with a 35% mass fraction (MF) consisting of silicon rubber and iron particles. It was fitted with aluminum couplers and attached to the shaft (drill string) to study its efficiency in vibration isolation under a magnetic field. Two tests were conducted on the drilling prototype setup used in this work; the first test was a hammer impact test. The torsional transfer function TTF analysis showed that the system's natural frequency has shifted from 13.9 Hz to 17.5 Hz by the influence of increasing magnetic field around the MRE. The results showed that the continuous rotational vibration amplitude of the prototype is attenuated by more than 40%.","PeriodicalId":9295,"journal":{"name":"Building Resilience at Universities: Role of Innovation and Entrepreneurship","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82915640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-20DOI: 10.29117/quarfe.2021.0034
Touria Bounnit, I. Saadaoui, R. Rasheed, Hareb Al jabri, S. Sayadi, A. Ayesh
Oxide nanoparticles are among the most used nanomaterials and have received considerable attention over their potential ecological effects. Increasing investigations report toxicity of certain oxide nanoparticles, however, there are also studies showing opposite results, highlighting the fact that these nanoparticles may differ in their toxicological effects, which depend on particle variety and size, test organism species, and test method. The current study investigates the ecotoxicity of SnO2 nanoparticles on a local marine algae isolate. Five different concentrations (1, 5, 25, 50 and 100mg/L) were tested and the culture was followed for 72h. Algae growth, morphology and metabolites were followed each 24h. The obtained data showed that the SnO2 presented a toxicity on the algae growth that was decreasing with the dose, with lower doses presenting more negative impacts than the higher doses. In parallel, the slow growth observed at 1-5 mg/L was explained by the dramatic damages caused by the SnO2 on the cell morphology, which was detected using the scanning electronic microscopy. Indeed, this low negative impact of higher concentrations of SnO2 (50-100mg/L) is explained by the high agglomeration of ten particles leading to reduced effect on the cell morphology and health. Furthermore, and in accordance with the morphological data, the metabolites analysis data revealed that SnO2 nanoparticles induced stress, which was manifested by an increase in the lipid content and decrease in the proteins, a metabolite that is involved in the algal growth.
{"title":"Assessment of SnO2 Nanoparticles’ Impact on local Pichoclorum Atomus Growth Performance, Cell Morphology and Metabolites Content","authors":"Touria Bounnit, I. Saadaoui, R. Rasheed, Hareb Al jabri, S. Sayadi, A. Ayesh","doi":"10.29117/quarfe.2021.0034","DOIUrl":"https://doi.org/10.29117/quarfe.2021.0034","url":null,"abstract":"Oxide nanoparticles are among the most used nanomaterials and have received considerable attention over their potential ecological effects. Increasing investigations report toxicity of certain oxide nanoparticles, however, there are also studies showing opposite results, highlighting the fact that these nanoparticles may differ in their toxicological effects, which depend on particle variety and size, test organism species, and test method. The current study investigates the ecotoxicity of SnO2 nanoparticles on a local marine algae isolate. Five different concentrations (1, 5, 25, 50 and 100mg/L) were tested and the culture was followed for 72h. Algae growth, morphology and metabolites were followed each 24h. The obtained data showed that the SnO2 presented a toxicity on the algae growth that was decreasing with the dose, with lower doses presenting more negative impacts than the higher doses. In parallel, the slow growth observed at 1-5 mg/L was explained by the dramatic damages caused by the SnO2 on the cell morphology, which was detected using the scanning electronic microscopy. Indeed, this low negative impact of higher concentrations of SnO2 (50-100mg/L) is explained by the high agglomeration of ten particles leading to reduced effect on the cell morphology and health. Furthermore, and in accordance with the morphological data, the metabolites analysis data revealed that SnO2 nanoparticles induced stress, which was manifested by an increase in the lipid content and decrease in the proteins, a metabolite that is involved in the algal growth.","PeriodicalId":9295,"journal":{"name":"Building Resilience at Universities: Role of Innovation and Entrepreneurship","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88823456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-20DOI: 10.29117/quarfe.2021.0002
Mohammed Alsafran, Mohammed Akkbik, A. Ahmadi, Mohammad I. Ahmad
Honey produced by bees from nectar in flowers and plants, is an aqueous supersaturated sugar solution, mainly monosaccharide (fructose and glucose) (70%–80%) and water (10%–20%). 5-Hydroxymethylfurfural (5-HMF) content in honey bee is an indicator of the purity. High concentration of 5-HMF in honey bee indicates overheating and poor storage conditions (The chemical properties of honey, free acids and total acids) significantly in correlation with the HMF content and provides parameters that are used to make quick assessments of honey quality (Khalil et al., 2010). The recommended value of 5-HMF (Alinorm 01/25, 2000) and the European Union (Directive 110/2001) in honey usually should not exceed 80 or 40 mg/kg, respectively. This work aims to examine the concentration of 5-Hydroxymethylfurfural (5-HMF) content in different Qatari honey bee samples as an indicator of the honey bee quality by using the reference White Method.
蜜蜂从花卉和植物的花蜜中提取蜂蜜，是一种含水过饱和糖溶液，主要是单糖(果糖和葡萄糖)(70%-80%)和水(10%-20%)。蜜蜂体内5-羟甲基糠醛(5-HMF)的含量是衡量蜂蜜纯度的一个指标。蜜蜂体内高浓度的5-羟甲基糠醛表明过热和储存条件差(蜂蜜的化学性质、游离酸和总酸)与羟甲基糠醛含量显著相关，并为快速评估蜂蜜质量提供了参数(Khalil et al.， 2010)。蜂蜜中5-羟甲基糠醛的推荐值(Alinorm 01/ 25,2000)和欧盟(Directive 110/2001)通常不应分别超过80或40毫克/公斤。本研究旨在利用参考白法检测不同卡塔尔蜜蜂样品中5-羟甲基糠醛(5-HMF)含量的浓度作为蜜蜂质量的指标。
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Pub Date : 2021-10-20DOI: 10.29117/quarfe.2021.0106
S. Kuttikrishnan, K. Prabhu, T. Elimat, Ashraf Khalil, N. Oberlies, F. Alali, S. Uddin
Cancer is one of the most life threatening diseases, causing nearly 13% death in the worldwide. Leukemia, cancer of the hematopoetic cells is the main cause of cancer death in adults and children. Therapeutic agents used in treatment of cancer are known to have narrow therapeutic window and tendency to develop resistance against some cancer cell lines thus, proposing a need to discover some novel agents to treat cancer. In the present study we investigated the anticancer activity of Neosetophomone B(NSP-B), an aquatic fungal metabolite isolated from Neosetophoma sp against leukemic cells (K562 and U937). MTT results demonstrated a dose dependent inhibition of cell proliferation in K562 and U937 cell lines. Annexin staining using flow cytometry indicated that NSP-B treatment cause a dose dependent apoptosis in leukemic cells.Western blot analysis showed that NSP-B mediated apoptosis involves sequential activation of caspase 9, 3 and poly (ADP-ribose) polymerase (PARP) cleavage. Furthermore NSP-B treatment of leukemic cells resulted in upregulation of pro-apoptotic proteins (Bax) with downregulation of anti-apoptotic proteins ( Bcl-2 ).Thus, present study focuses on exploring the mechanism of anticancer activity of NSP-B on leukemic cells, raising the possibility of its use as a novel therapeutic agent for hematological malignancies. Results: We sought to determine whether NSP-B suppresses the growth of leukemic cell lines. We tested a panel of leukemic cell lines with different doses of NSP-B. Cell viability decreased in a concentration-dependent manner in K562 and U937 cell lines. NSP-B induced apoptosis in K562 and U937 cell lines via downregulation of anti-apoptotic proteins and enhancement of pro-apoptotic proteins. NSP-B induced the activation of caspase cascade signaling pathway. Altogether our results suggest that the NSP-B plays an important role in apoptosis in leukemic cell lines .Conclusions: Our data provides insight on anticancer activities of NSP-B in leukemic cell lines (K562 and U937). NSP-B inhibit cell viability via inducing apoptosis. The NSP-B mediated apoptosis occurs via downregulation of anti-apoptotic proteins and enhancement of pro-apototic proteins, thereby activating the caspase-cascade signaling. Further studies are required to elicit role of NSP-B in regulating molecular pathway involved in the progression of cancer. Taken together, above results suggest that NSP-B may have a future therapeutic role in leukemia and possibly other hematological malignancies.
{"title":"Anticancer Activity of Neosetophomone B, An Aquatic Fungal Secondary Metabolite, Against Hematological Malignancie S","authors":"S. Kuttikrishnan, K. Prabhu, T. Elimat, Ashraf Khalil, N. Oberlies, F. Alali, S. Uddin","doi":"10.29117/quarfe.2021.0106","DOIUrl":"https://doi.org/10.29117/quarfe.2021.0106","url":null,"abstract":"Cancer is one of the most life threatening diseases, causing nearly 13% death in the worldwide. Leukemia, cancer of the hematopoetic cells is the main cause of cancer death in adults and children. Therapeutic agents used in treatment of cancer are known to have narrow therapeutic window and tendency to develop resistance against some cancer cell lines thus, proposing a need to discover some novel agents to treat cancer. In the present study we investigated the anticancer activity of Neosetophomone B(NSP-B), an aquatic fungal metabolite isolated from Neosetophoma sp against leukemic cells (K562 and U937). MTT results demonstrated a dose dependent inhibition of cell proliferation in K562 and U937 cell lines. Annexin staining using flow cytometry indicated that NSP-B treatment cause a dose dependent apoptosis in leukemic cells.Western blot analysis showed that NSP-B mediated apoptosis involves sequential activation of caspase 9, 3 and poly (ADP-ribose) polymerase (PARP) cleavage. Furthermore NSP-B treatment of leukemic cells resulted in upregulation of pro-apoptotic proteins (Bax) with downregulation of anti-apoptotic proteins ( Bcl-2 ).Thus, present study focuses on exploring the mechanism of anticancer activity of NSP-B on leukemic cells, raising the possibility of its use as a novel therapeutic agent for hematological malignancies. Results: We sought to determine whether NSP-B suppresses the growth of leukemic cell lines. We tested a panel of leukemic cell lines with different doses of NSP-B. Cell viability decreased in a concentration-dependent manner in K562 and U937 cell lines. NSP-B induced apoptosis in K562 and U937 cell lines via downregulation of anti-apoptotic proteins and enhancement of pro-apoptotic proteins. NSP-B induced the activation of caspase cascade signaling pathway. Altogether our results suggest that the NSP-B plays an important role in apoptosis in leukemic cell lines .Conclusions: Our data provides insight on anticancer activities of NSP-B in leukemic cell lines (K562 and U937). NSP-B inhibit cell viability via inducing apoptosis. The NSP-B mediated apoptosis occurs via downregulation of anti-apoptotic proteins and enhancement of pro-apototic proteins, thereby activating the caspase-cascade signaling. Further studies are required to elicit role of NSP-B in regulating molecular pathway involved in the progression of cancer. Taken together, above results suggest that NSP-B may have a future therapeutic role in leukemia and possibly other hematological malignancies.","PeriodicalId":9295,"journal":{"name":"Building Resilience at Universities: Role of Innovation and Entrepreneurship","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80665860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-20DOI: 10.29117/quarfe.2021.0124
M. Mustafa, Najlaa Al-Qahtani, K. Yusuff
Automated systems have been crucial to reducing medication errors and improving patient safety. However, their use has increased medication-errors associated with other factors:socio-technical interactions, automation bias, workarounds, and overrides. This comprehensive systematic review was conducted to identify types and severity of medication-errors associated with the use of automated system in all stages of the medication use process. This provides new perspectives that contribute significantly to global knowledge in the research area. Three databases were searched to include English-language observational and experimental studies(from 2000-2019) focused on types and severity of medication errors. A data-extraction form was developed, and quality was assessed using Hoy-et-al tool. The search yielded 860 articles after deduplication and thirteen were eligible. The bias risk was low for eight studies(62%) and moderate for five(38%). The medication-error types, and prevalence were omitted information(4-61%), wrong dose(4-30%), incorrect medication(1-18%), incorrect administration time(3-18%), and incorrect frequency(0.6%-21%) and occurred in the prescribing(62%) and administration(69%) stage. The error severity assessment used was NCC-MERP-index(46%), other(23%), or not conducted(31%). Omitted information and incorrect dose were the most common errors associated with automated systems in the prescribing and administration stages. However, the error severity and classification was inconclusive due to differences in study design and assessment criteria.
{"title":"Types and Severity of Medication-Errors with Automated Systems within Medication-Use Process: Systematic-Review","authors":"M. Mustafa, Najlaa Al-Qahtani, K. Yusuff","doi":"10.29117/quarfe.2021.0124","DOIUrl":"https://doi.org/10.29117/quarfe.2021.0124","url":null,"abstract":"Automated systems have been crucial to reducing medication errors and improving patient safety. However, their use has increased medication-errors associated with other factors:socio-technical interactions, automation bias, workarounds, and overrides. This comprehensive systematic review was conducted to identify types and severity of medication-errors associated with the use of automated system in all stages of the medication use process. This provides new perspectives that contribute significantly to global knowledge in the research area. Three databases were searched to include English-language observational and experimental studies(from 2000-2019) focused on types and severity of medication errors. A data-extraction form was developed, and quality was assessed using Hoy-et-al tool. The search yielded 860 articles after deduplication and thirteen were eligible. The bias risk was low for eight studies(62%) and moderate for five(38%). The medication-error types, and prevalence were omitted information(4-61%), wrong dose(4-30%), incorrect medication(1-18%), incorrect administration time(3-18%), and incorrect frequency(0.6%-21%) and occurred in the prescribing(62%) and administration(69%) stage. The error severity assessment used was NCC-MERP-index(46%), other(23%), or not conducted(31%). Omitted information and incorrect dose were the most common errors associated with automated systems in the prescribing and administration stages. However, the error severity and classification was inconclusive due to differences in study design and assessment criteria.","PeriodicalId":9295,"journal":{"name":"Building Resilience at Universities: Role of Innovation and Entrepreneurship","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86960546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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