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Investigational Study for the efficiency of Fe3O4@SiO2 nanoparticles in the Oil Recovery Process using glass micromodel 利用玻璃微模型研究Fe3O4@SiO2纳米颗粒在采油过程中的效率
Pub Date : 2021-10-20 DOI: 10.29117/quarfe.2021.0062
Wamda Elhaj, F. Almomani
Nanofluids have shown their potential in the oil recovery process through surface modification. Due to their surface characteristics, they can apply to improve the oil production from reservoirs by enabling different enhanced recovery mechanisms. The preparation and development of the Fe3O4@SiO2 nanoparticles for the oil recovery process is an innovative and novel approach that influences the oil generation from reservoirs. The performance of the Fe3O4@SiO2 and the other nanofluids (seawater, Fe3O4, and SiO2) in the enhanced oil recovery process is assessed and compared with other flooding scenarios. The Fe3O4@SiO2 NPs achieved the highest oil production rate of 90.2%, while Fe3O4 and SiO2 NPs achieved 70.8% and 55.3%, respectively. In contrast, the value achieved for the seawater injection was 76.5%. For the oil recovery process, the Fe3O4 was applied for the inhibition (i.e., decrease) of oil sedimentation, and the SiO2 NPs were applied for wettability alteration and IFT reduction. The experimental results showed that the produced Fe3O4@SiO2 NPs improved the oil recovery rates (90.2%) as well as the synergetic impact of the developed NPs by initiating several mechanisms corresponding to the use of the separate NPs in the micromodel. Moreover, the results exhibited that the reservoir conditions are a crucial function for increasing the oil recovery rates, improving the emulsion stability, and is a substantial step for the oil recovery method that applies this particular technique.
纳米流体通过表面改性在采油过程中显示出其潜力。由于其表面特性,它们可以通过实现不同的提高采收率机制来提高油藏的产油量。制备和开发用于采油过程的Fe3O4@SiO2纳米颗粒是一种影响油藏生油的创新方法。对Fe3O4@SiO2和其他纳米流体(海水、Fe3O4和SiO2)在提高采收率过程中的性能进行了评价,并与其他驱油场景进行了比较。Fe3O4@SiO2 NPs的产油率最高,为90.2%,Fe3O4和SiO2 NPs的产油率分别为70.8%和55.3%。相比之下,海水注入所达到的数值为76.5%。在采油过程中,使用Fe3O4来抑制(即减少)石油沉积,使用SiO2 NPs来改变润湿性和降低IFT。实验结果表明,通过启动与微观模型中单独NPs的使用相对应的几种机制,生产的Fe3O4@SiO2 NPs提高了石油采收率(90.2%),并提高了已开发NPs的协同影响。此外,研究结果表明,储层条件对提高采收率、改善乳状液稳定性起着至关重要的作用,是应用该技术采油方法的重要一步。
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引用次数: 0
The Efficacy of Two Household Cleaning and Disinfecting Agents on Lentil (Lens culinaris Medik) and Faba bean (Vicia faba) Seed Germination 两种家用清洁消毒剂对小扁豆(Lens culinaris Medik)和蚕豆种子发芽的影响
Pub Date : 2021-10-20 DOI: 10.29117/quarfe.2021.0023
Ahmed Helmy Hassan Abouelezz, T. Ahmed
A germination test of Vicia faba and Lens culinaris seeds under the effect of bleach and vinegar was conducted for seven days, and the observations were recorded daily. The completely randomized design (CRD) was used to examine the germination with three replicates at the lab conditions. Six germination parameters were measured, including germination percentage (GP), germination index (GI), mean germination time (MGT), mean germination rate (MGR), vigour index (VI), plus the fresh weight (FW) and dry weight (DW) of Vicia faba and Lens culinaris seeds. As a legume crop seeds model, the efficacy of four treatment levels from 0.005% to 0.5% of bleach and vinegar on the germination was tested. A chemical analysis was performed using the ion chromatography (IC) to evaluate the effect of chloride and acetate anions up-take on the seedling germination in addition to other essential nutrients. A significant inhibition in seedling growth was observed with increasing the treatment concentration. The maximum inhibition was recorded for both seeds at 0.5%, followed by 0.1% levels, while a positive effect was represented with the lower concentrations. The chemical analysis of the up-taking active ingredients was corroborated by the germination outputs.
用漂白剂和白醋对蚕豆和水杨花种子进行了为期7天的萌发试验,并每天记录试验结果。采用完全随机设计(CRD),在实验室条件下进行3个重复的发芽试验。测定了蚕豆种子的发芽率(GP)、发芽指数(GI)、平均发芽时间(MGT)、平均发芽率(MGR)、活力指数(VI)、鲜重(FW)和干重(DW) 6项萌发参数。以豆科作物种子为模型,试验了0.005% ~ 0.5%漂白剂和食醋4种处理水平对豆科作物种子萌发的影响。利用离子色谱法(ion chromatography, IC)分析了氯离子和醋酸离子吸收对幼苗萌发的影响。随着处理浓度的增加,对幼苗生长有明显的抑制作用。两种种子的抑菌效果均在0.5%时达到最大值,其次为0.1%,较低浓度的抑菌效果最好。发芽结果证实了吸收活性成分的化学分析。
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引用次数: 0
The Influence of Qatari Dust on the Element Composition of Marine Plankton 卡塔尔粉尘对海洋浮游生物元素组成的影响
Pub Date : 2021-10-20 DOI: 10.29117/quarfe.2021.0019
O. Yigiterhan, Jassem A. Al-Thani, S. Dib, H. Alsaadi, E. M. Al-Ansari
The Exclusive Economic Zone (EEZ) of Qatar is affected by extreme dust and extensive industrialization, making it an ideal location to examine influences of coastal processes on biological activity, which greatly affects marine biogeochemical cycling. In this study, the influence of dust on the trace element composition of plankton and how distance from shore effects elemental concentrations in marine plankton was investigated. Samples were collected using net tows with mesh sizes of 50 (bulkplankton) and 200 (zooplankton) mm size-fractions in 2012 and 2014 to examine temporal and spatial variabilities. The samples were strong acid digested and analyzed using ICP-OES. Trace metal clean techniques were used. The biogenic concentrations of trace metals were determined by correcting the bulk analyses for the lithogenic contribution using aluminum content of Qatari dust as a lithogenic tracer. The relative trace metal composition of plankton from EEZ of Qatar is Fe > Zn ≈ Cu > V ≈ Ni ≈ Cr ≈ As ≈ Mo > Cd ≈ Co. Small and large size planktonic compositions were similar, except for Ba, Mn, Pb, Mo which were higher in zooplankton than bulkplankton. It was not clear if the variability was due to differences in biology, proximity to the coast or interannual effects. The geochemical and statistical analysis suggested that the concentrations of Al, Fe, Cr, Co, Mn, Ni, Pb, Li in net-tow plankton samples were mostly of lithogenic (dust) and Cd, Cu, Mo, Zn, Ca are most likely of biogenic/anthropogenic origin. The excess concentrations relative to average dust from Qatar for most elements (except Cd) decreased with distance from shore. This may be due to contamination or uncertainties with the lithogenic correction or due to our sampling locations in a marginal sea, dominated by dust input. This is an aspect of this study that warrants more research.
卡塔尔的专属经济区(EEZ)受到极端粉尘和广泛工业化的影响,使其成为研究沿海过程对生物活动影响的理想地点,这极大地影响了海洋生物地球化学循环。本文研究了扬尘对浮游生物微量元素组成的影响,以及离岸距离对海洋浮游生物元素浓度的影响。2012年和2014年,采用网眼尺寸分别为50(散装浮游生物)和200(浮游动物)mm的网眼收集样本,以检验时空变化。样品经强酸消化,ICP-OES分析。采用微量金属清洁技术。微量金属的生物成因浓度是通过校正大块分析来确定的,以卡塔尔粉尘的铝含量为岩石成因示踪剂。卡塔尔专属经济区浮游生物的相对微量金属组成为Fe > Zn≈Cu > V≈Ni≈Cr≈As≈Mo > Cd≈Co,除Ba、Mn、Pb、Mo在浮游动物中高于整体浮游生物外,大小浮游动物的微量金属组成基本相同。目前尚不清楚这种变化是由于生物学的差异、靠近海岸还是年际影响。地球化学和统计分析表明,净拖浮游生物样品中Al、Fe、Cr、Co、Mn、Ni、Pb、Li的浓度主要为岩石质(粉尘)来源,Cd、Cu、Mo、Zn、Ca的浓度主要为生物/人为来源。相对于来自卡塔尔的平均粉尘,大多数元素(除Cd外)的过量浓度随着离海岸的距离而降低。这可能是由于污染或岩石校正的不确定性,或者由于我们的采样位置在边缘海,主要是灰尘输入。这是这项研究的一个值得进一步研究的方面。
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引用次数: 0
Additive Manufacturing of Smart Material and Complex Structures 智能材料和复杂结构的增材制造
Pub Date : 2021-10-20 DOI: 10.29117/quarfe.2021.0079
Sajeel N K, Muni Raj Maurya, Mohammed Houkan, K. K. Sadasivuni
Additive Manufacturing (AM), typically referred to as rapid prototyping or three-dimensional (3D) printing has rapidly emerged as a sustainable, highly efficient and intelligent tool. Moreover, recent developments in novel materials and software tools have synergistically expanded the stage for additive manufacturing. Here we present the fabricated 3D printed objects for application in biomedical, sensor, gas filter and fluid flow controllers. The fabricated CO2 gas sensor exhibited the sensitivity of as low as 10 ppm and offered high selectivity towards other gases.
增材制造(AM),通常被称为快速原型或三维(3D)打印,已迅速成为一种可持续、高效和智能的工具。此外,新材料和软件工具的最新发展协同扩大了增材制造的舞台。在这里,我们展示了用于生物医学,传感器,气体过滤器和流体流量控制器的3D打印对象。所制备的CO2气体传感器的灵敏度低至10ppm,对其他气体具有很高的选择性。
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引用次数: 0
Is curcumin at the threshold of therapeutic effectiveness on patients with colon cancer? – A systematic review 姜黄素对结肠癌患者有治疗效果吗?-系统检讨
Pub Date : 2021-10-20 DOI: 10.29117/quarfe.2021.0118
Laila Shafei, M. Izham, N. Billa
Curcumin, obtained from Curcuma longa, has been the subject of decades of scientific investigation on its therapeutic usefulness. It is reported to possess several therapeutic properties, of which anti-colon cancer is of interest in this review. Clinically, however, curcumin has yet to firm up its place among established anti-colon cancer therapeutic contenders. We aimed to systematically review the prevailing clinical evidence on the role of curcumin in colon cancer treatment. The review drawing from literature on clinical studies indicates fairly long-term tolerability. No regression of tumor was reported when curcumin was the sole intervention. An increase in p53 level expression was reported in a placebo-controlled study but no reduction in PGE2 or 5HETE. Pharmacokinetic data on healthy humans indicate that formulated curcumin delivery systems present significantly higher systemic bioavailability. It appears therefore that the clinical use of curcumin can potentially be realized only through appropriate formulation interventions
姜黄素,从姜黄中提取,已经对其治疗作用进行了几十年的科学研究。据报道,它具有几种治疗特性,其中抗结肠癌是本综述感兴趣的。然而,在临床上,姜黄素尚未在已建立的抗结肠癌治疗竞争者中站稳脚跟。我们旨在系统地回顾姜黄素在结肠癌治疗中的作用的主要临床证据。从临床研究文献中得出的综述表明,该药具有相当长的耐受性。当姜黄素是唯一的干预措施时,没有肿瘤消退的报道。在一项安慰剂对照研究中报告了p53水平表达的增加,但PGE2或5HETE没有减少。健康人体的药代动力学数据表明,配方姜黄素输送系统显着提高了系统生物利用度。因此,姜黄素的临床应用似乎只有通过适当的配方干预才能实现
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引用次数: 0
Reno-protective Effect of Angiotensin Receptor Blocker in Spontaneously Hypertensive Rat Models: A Systematic Review 血管紧张素受体阻滞剂对自发性高血压大鼠肾保护作用的系统综述
Pub Date : 2021-10-20 DOI: 10.29117/quarfe.2021.0111
Salma Mohammed AlDakhakhny, Mohamed Izham Mohamed Ibrahim, H. Rathore, M. Hamed
Background Chronic Kidney Disease (CKD) is highly prevalent among hypertensive population. Previous date from studies and experiments have confirmed the reno-protective effect and tolerability of angiotensin receptor blockers in diabetic nephropathy. However, clinical data are lacking in hypertensive population. Objectives This is the first meta-analysis to evaluate the surrogate outcomes of renal protection with ARBs in hypertensive rodents to serve as a baseline for further studies. Methods The systematic review was conducted following the PRISM checklist. Four different databases were searched including PubMed, EMBASE, ScienceDirect and SCOPUS. No restrictions were applied on dose, duration of follow up or ARBs used. Inclusion was restricted to experimental studies reporting means and SEM, published in English, addressing the PICO question and having a moderate to high quality. 37 total eligible articles were identified and Results: Of 25 reported primary outcomes in comparison to hypertensive untreated controls, 23 studies showed positive results supporting that ARBs induce reduction in proteinuria and/or albuminuria compared to hypertensive untreated controls. Similarly, in comparison to normotensive untreated controls, 9 of 12 studies showed positive results supporting that ARBs’ induced reduction in proteinuria and/or albuminuria can reach levels similar to normotensive controls. For the secondary outcomes, 12 of 18 reported outcomes showed significant improvement in CrCl or reduction in BUN compared to hypertensive untreated rats. Similarly, 10 of 17 outcomes reported showed that the improvement in secondary outcomes reached levels that are comparable to normotensive controls. Conclusion: Qualitative data from this systematic review support that ARBs have a Reno-protective effect in different hypertensive models and the effect is independent of BP lowering.
背景:慢性肾脏疾病(CKD)在高血压人群中非常普遍。先前的研究和实验证实了血管紧张素受体阻滞剂对糖尿病肾病的肾保护作用和耐受性。然而,高血压人群的临床资料缺乏。这是第一个评估arb对高血压啮齿动物肾脏保护替代结果的荟萃分析,可作为进一步研究的基线。方法按照PRISM检查表进行系统评价。检索了四个不同的数据库,包括PubMed、EMBASE、ScienceDirect和SCOPUS。对剂量、随访时间或使用的arb没有限制。纳入仅限于实验研究报告手段和扫描电镜,以英文发表,解决PICO问题,具有中等到高质量。结果:与未治疗的高血压对照组相比,25项报告的主要结果中,23项研究显示阳性结果,支持ARBs与未治疗的高血压对照组相比,可诱导蛋白尿和/或蛋白尿减少。同样,与血压正常的对照组相比,12项研究中有9项显示阳性结果,支持ARBs诱导的蛋白尿和/或蛋白尿减少可达到与血压正常对照组相似的水平。对于次要结果,18个报告的结果中有12个显示与未治疗的高血压大鼠相比,CrCl显著改善或BUN显著降低。同样,17个结果中有10个报告显示次要结果的改善达到了与正常对照组相当的水平。结论:本系统评价的定性数据支持ARBs在不同高血压模型中具有雷诺保护作用,且作用与降压无关。
{"title":"Reno-protective Effect of Angiotensin Receptor Blocker in Spontaneously Hypertensive Rat Models: A Systematic Review","authors":"Salma Mohammed AlDakhakhny, Mohamed Izham Mohamed Ibrahim, H. Rathore, M. Hamed","doi":"10.29117/quarfe.2021.0111","DOIUrl":"https://doi.org/10.29117/quarfe.2021.0111","url":null,"abstract":"Background Chronic Kidney Disease (CKD) is highly prevalent among hypertensive population. Previous date from studies and experiments have confirmed the reno-protective effect and tolerability of angiotensin receptor blockers in diabetic nephropathy. However, clinical data are lacking in hypertensive population. Objectives This is the first meta-analysis to evaluate the surrogate outcomes of renal protection with ARBs in hypertensive rodents to serve as a baseline for further studies. Methods The systematic review was conducted following the PRISM checklist. Four different databases were searched including PubMed, EMBASE, ScienceDirect and SCOPUS. No restrictions were applied on dose, duration of follow up or ARBs used. Inclusion was restricted to experimental studies reporting means and SEM, published in English, addressing the PICO question and having a moderate to high quality. 37 total eligible articles were identified and Results: Of 25 reported primary outcomes in comparison to hypertensive untreated controls, 23 studies showed positive results supporting that ARBs induce reduction in proteinuria and/or albuminuria compared to hypertensive untreated controls. Similarly, in comparison to normotensive untreated controls, 9 of 12 studies showed positive results supporting that ARBs’ induced reduction in proteinuria and/or albuminuria can reach levels similar to normotensive controls. For the secondary outcomes, 12 of 18 reported outcomes showed significant improvement in CrCl or reduction in BUN compared to hypertensive untreated rats. Similarly, 10 of 17 outcomes reported showed that the improvement in secondary outcomes reached levels that are comparable to normotensive controls. Conclusion: Qualitative data from this systematic review support that ARBs have a Reno-protective effect in different hypertensive models and the effect is independent of BP lowering.","PeriodicalId":9295,"journal":{"name":"Building Resilience at Universities: Role of Innovation and Entrepreneurship","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87318549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nurses’ Knowledge and Attitudes about Adult Post-operative Pain Assessment and Management: A Cross-Sectional Study in Qatar 卡塔尔护士对成人术后疼痛评估和处理的知识和态度:一项横断面研究
Pub Date : 2021-10-20 DOI: 10.29117/quarfe.2021.0101
Haya Samara, L. OHara
Background: Pain has been described by clinicians, patients, and researchers alike as a complex and challenging phenomenon. People have different experiences of pain. Nurses’ negative attitudes and lack of knowledge are major impediments to effective pain management. Methods: The study was a cross-sectional online survey using a validated self-administered questionnaire for post-operative registered nurses working in Hamad Medical Corporation in Qatar. The dependent outcome was the score on the Knowledge and Attitudes Survey Regarding Pain. Results: A total of 151 post-operative nurses participated in the study. The mean knowledge and attitudes (K&A) score was 19.6 (SD 4.5) out of 41 (48%), indicating a huge deficit in the nurses’ knowledge and attitudes about adult post-operative pain. No sociodemographic variables were associated with K&A scores. Neither the facility the nurses worked at nor hours of previous pain education were associated with K&A scores. Conclusions: There is a significant deficit in post-operative nurses’ knowledge and attitudes about pain in Hamad Medical Corporation, with no significant differences based on demographics or other characteristics. This suggests the deficit is widespread within the nursing workforce in Qatar. This deficit is potentially impacting significantly on pain assessment and management for adults in post-operative settings. Pragmatic research on evidence-based nursing educational courses focused on pain assessment and management is required to enhance nurses’ knowledge and attitudes and improve patient care. Key messages: Strategies to strengthen nurses’ knowledge and attitudes toward pain in Qatar must be developed and tested.
背景:临床医生、患者和研究人员都认为疼痛是一种复杂而具有挑战性的现象。人们对疼痛有不同的体验。护士的消极态度和缺乏知识是有效管理疼痛的主要障碍。方法:采用横断面在线调查方法,对卡塔尔哈马德医疗公司的术后注册护士进行问卷调查。依赖结果是关于疼痛的知识和态度调查的分数。结果:151名术后护理人员参与了本研究。在41分(48%)中,平均知识和态度(K&A)得分为19.6分(SD 4.5分),表明护士对成人术后疼痛的知识和态度存在巨大缺陷。没有社会人口学变量与K&A分数相关。护士工作的机构和先前疼痛教育的时间与K&A分数无关。结论:哈马德医疗公司术后护士对疼痛的知识和态度存在明显缺陷,在人口统计学和其他特征上无显著差异。这表明,在卡塔尔的护理人员队伍中,这种赤字很普遍。这一缺陷可能对成人术后疼痛评估和管理产生重大影响。需要对以疼痛评估和管理为重点的循证护理教育课程进行务实研究,以提高护士的知识和态度,改善患者护理。关键信息:必须制定和测试加强卡塔尔护士对疼痛的知识和态度的战略。
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引用次数: 3
Novel Prosopis Juliflora Leaf Ethanolic extract as natural Antifungal agent against Botrytis Cinerea: Application on Strawberries’ shelf-life extension 新型黄豆叶乙醇提取物作为天然抗葡萄孢菌剂在草莓保鲜期中的应用
Pub Date : 2021-10-20 DOI: 10.29117/quarfe.2021.0044
Iman Saleh, Mohammed H. Abu-Dieyeh
Spoilage from fresh produces is a worldwide concern that accompanies the global increase in food demand. Adverse human health and environmental effects of commercial pesticides is a major public concern. Botrytis cinerea is one of the top ten pathogens that affect fresh produce including strawberries’ shelf-life around the world. Botrytis cinerea can progress easily from infected fruits to healthy ones even at low storage temperatures, which can lead to spoilage of entire lots in few weeks. Strawberries are widely consumed raw berries, which are famous in their processed forms such as jam and juices. The delicate fruit has a very short postharvest life. It is susceptible to mechanical injuries, fast dehydration and fungal infection. Prosopis juliflora is an invasive tree in many countries including Qatar. In this report, the Prosopis juliflora water soluble leaves ethanolic (PJ-WS-LE) novel extraction method will be described with an evaluation of its effectiveness as antifungal agent and possible coating material for shelf-life extension. PJ-WS-LE extract showed total inhibition of Botrytis cinerea growth with a minimum inhibitory concentration of 1mg/ml. Exposure to the extract affected badly the structure of the hyphal fungi. The extract extended also strawberries’ shelf-life by 2.32X. PJ-WS-LE extract will be chemically described and its effectiveness in the extension of other fresh produces’ shelf-life will be evaluated.
随着全球粮食需求的增长,新鲜农产品的腐败问题已成为全球关注的问题。商业农药对人类健康和环境的不利影响是公众关注的一个主要问题。葡萄孢杆菌是影响包括草莓在内的世界各地新鲜农产品保质期的十大病原体之一。即使在较低的储存温度下,灰霉病菌也可以很容易地从受感染的水果发展到健康的水果,这可能导致整个批次在几周内变质。草莓是广泛食用的生浆果,其加工形式如果酱和果汁很有名。这种娇嫩的水果采后寿命很短。它容易受到机械损伤、快速脱水和真菌感染。黄豆豆是包括卡塔尔在内的许多国家的入侵树种。本文介绍了槐叶水溶性乙醇(PJ-WS-LE)的新提取方法,并对其作为抗真菌剂和延长保质期的包衣材料进行了评价。PJ-WS-LE提取物对灰霉病菌的生长具有完全抑制作用,最低抑制浓度为1mg/ml。暴露于提取物严重影响菌丝真菌的结构。该提取物还将草莓的保质期延长了2.32倍。将对PJ-WS-LE提取物进行化学描述,并对其延长其他生鲜产品保质期的有效性进行评价。
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引用次数: 0
Effective Smart Contracts for Supply Chain Contracts 有效的供应链智能合约
Pub Date : 2021-10-20 DOI: 10.29117/quarfe.2021.0160
Bajeela Aejas, Abdelaziz Bouras
Blockchain is in its way of revolutionizing different sectors with its decentralized peer-to-peer networking. Smart contracts are the piece of software that have written rules to be executed automatically to update the state of the block chain in a systematic way. One of the main use of Smart contract is in Supply Chain management. Supply Chain management deals with lot of legal contracts at a time. Contracts are agreements between two or more parties that define the duties and obligations for execution of any kind of activities. In this research, we are trying to automate the supply chain related contracts by identifying the important entities such as contract type, start date, end date etc., by using Natural Language Processing methods, then convert the contract to smart contract. This provides an efficient template for creation of smart contracts from natural language contracts and thereby offer best smart contract template for a given type of contract in Supply Chain.
区块链正以其去中心化的点对点网络来彻底改变不同的行业。智能合约是一种软件,它编写了自动执行的规则,以系统的方式更新区块链的状态。智能合约的主要用途之一是供应链管理。供应链管理同时处理大量的法律合同。合同是双方或多方之间的协议,定义了执行任何活动的责任和义务。在本研究中,我们试图通过使用自然语言处理方法识别合同类型、开始日期、结束日期等重要实体,然后将合同转换为智能合同,从而实现供应链相关合同的自动化。这为从自然语言合约创建智能合约提供了一个有效的模板,从而为供应链中给定类型的合约提供了最佳的智能合约模板。
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引用次数: 1
Genetic Susceptibility to Infectious Diseases in the Qatari Population 卡塔尔人口对传染病的遗传易感性
Pub Date : 2021-10-20 DOI: 10.29117/quarfe.2021.0092
M. Smatti, Y. Al-Sarraj, O. Albagha, H. Yassine
Background: Infectious diseases (IDs) account for 8% of deaths annually in Qatar, and therefore, represent a significant challenge for public health. Interestingly, the spread and severity of viral infections vary considerably between individuals and populations. The most recent example is SARS-CoV-2, which ranges from mild/asymptomatic to a severe respiratory syndrome. It has been previously reported that polymorphisms in genes linked to immunity can influence individuals’ responses to infections as observed in tuberculosis, influenza, and HIV; however, studies exploring causal host genetic variants in IDs are still limited and dramatically skewed with regard to population inclusion. In fact, the genetic susceptibility to IDs in the Qatari population is largely unknown. Aim: To perform a comprehensive genetic screening to investigate the presence and frequency of variants previously associated with various infections in the Qatari population. Methods: Whole-genome sequencing was previously performed for 18,000 QBB participants using Illumina HiSeq X Ten1 sequencers. The initial data processing and quality assessment of the raw data has also been performed and variant calling files (VCF) were created. We were granted the access to the VCF files of 6,218 sequenced samples. The genetic variant data was then converted to PLINK file format using PLINK-1.9. Standardized quality-assurance and quality control (QA/QC) methods were followed to generate high quality and confidence on both SNPs and sample levels. The final file used for calculating allele frequency contained 6,047 subjects. Additionally, list of infections-related SNPs that were previously reported in the literature and deposited in GWAS catalog was extracted and used to calculate and compare the allelic frequency in the Qatari genomes compared to other populations. Results: The frequency of infections-related SNPs in the Qatari population was significantly lower for most infections. Most variants (78%) showed negative fold change in the Qatari genomes. Only 22% of all variants were more prevalent in Qatari population compared to others. The most significant differences were observed in genes related to TB and HIV (200-940 and 160-710 fold change, respectively). Conclusion: This study reports a lower susceptibility of the Qatari population to IDs in general. Nonetheless, this might also indicate the presence of unknown Qatari-unique variants and hence, highlights the need for further investigation in future GWAS.
背景:传染病占卡塔尔每年死亡人数的8%,因此对公共卫生构成重大挑战。有趣的是,病毒感染的传播和严重程度在个人和人群之间差别很大。最近的例子是SARS-CoV-2,它的范围从轻度/无症状到严重的呼吸综合征。此前有报道称,在结核病、流感和艾滋病毒中观察到,与免疫相关的基因多态性可以影响个体对感染的反应;然而,在IDs中探索因果宿主遗传变异的研究仍然有限,并且在人群纳入方面显着偏斜。事实上,卡塔尔人群对id的遗传易感性在很大程度上是未知的。目的:进行全面的遗传筛查,以调查卡塔尔人群中与各种感染相关的变异的存在和频率。方法:先前使用Illumina HiSeq X Ten1测序仪对18,000名QBB参与者进行了全基因组测序。对原始数据进行了初始数据处理和质量评估,并创建了变量调用文件(VCF)。我们被允许访问6218个测序样本的VCF文件。然后使用PLINK-1.9将遗传变异数据转换为PLINK文件格式。采用标准化的质量保证和质量控制(QA/QC)方法,在snp和样品水平上产生高质量和置信度。用于计算等位基因频率的最终文件包含6047名受试者。此外,提取GWAS目录中已有文献报道的与感染相关的snp列表,用于计算和比较卡塔尔人基因组中与其他人群相比的等位基因频率。结果:卡塔尔人群中感染相关snp的频率在大多数感染中明显较低。大多数变异(78%)在卡塔尔基因组中显示负折叠变化。所有变异中只有22%在卡塔尔人群中比其他人群更普遍。最显著的差异是与结核病和艾滋病相关的基因(分别为200-940倍和160-710倍)。结论:本研究报告了卡塔尔人群对IDs的总体易感性较低。尽管如此,这也可能表明存在未知的卡塔尔独有变体,因此,强调了未来GWAS进一步研究的必要性。
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引用次数: 0
期刊
Building Resilience at Universities: Role of Innovation and Entrepreneurship
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