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Hydatid Cyst of the kidney and Ureter: A Review and Update of the Literature 肾脏和输尿管的棘球蚴病:文献回顾和更新
Pub Date : 2021-08-28 DOI: 10.31579/2690-1919/188
A. Venyo
Echinococcal (Hydatid) cyst of the kidney is a very uncommon disease which is sporadically reported in Echinococcal endemic areas of the world as well it tends to be reported in non-endemic areas in view of global travel on extremely rare occasions. Hydatid cyst of the kidney could manifest with non-specific symptoms including: loin/flank pain or discomfort; abdominal pain; a mass within the loin or abdomen; hydatiduria; abdominal distension; weight loss; other non-specific symptoms. A history of residence in or having travelled from an echinococcal endemic area and having been in contact with animals including dogs does play an important role in alerting the clinician regarding the possibility of Echinococcal disease is useful. The general and systematic examinations could be normal but tenderness within the loin and tenderness in the upper abdomen could be found which may or may not be associated with a palpable mass within the loin or upper abdomen. The results of routine haematology and biochemistry blood tests could be normal except at times there could be eosinophilia. Urinalysis could show hydatiduria. A positive Casoni intradermal test results or a positive Echinococcal serology test would tend to alert clinicians about Echinococcal disease. Radiology imaging of the abdomen and renal tract including ultrasound scan, computed tomography scan and magnetic resonance scan, of the abdomen would show the cyst (most commonly) or cysts, (occasionally) within the kidney as well the size of the cyst and the amount of normal looking renal parenchyma and presence of daughter cysts could be demonstrated. Furthermore, if there is hydronephrosis or hydroureter the radiology images would reveal it. Treatment of hydatid cyst of the kidney does entail treatment with a combination of: Cycles of anti-scolicidal medications of which albendazole is the commonest used medicament and. Surgical treatment could include: Laparoscopic Drainage of the hydatid cyst and peri-cystectomy. Laparoscopic partial nephrectomy. Laparoscopic nephrectomy excising the entire kidney on rare occasions. Laparoscopic nephroureterectomy when the ureter is also involved by hydatid cyst. Open surgical drainage of the hydatid cyst and peri-cystectomy. Open drainage of the hydatid cyst and partial nephrectomy. Open drainage of the hydatid cyst and full nephrectomy. Open drainage of the hydatid cyst and nephroureterectomy if there is an associated hydatid cyst of the ureter. If there is an associated hydatid cyst elsewhere for example in the liver that cyst would also be carefully excised. Utilization of antiscolicidal medicaments alone without surgery had yielded poor results and recurrence of cysts with the exception of one reported case in which utilization of albendazole alone was associated with a good outcome. Aspiration alone of the hydatid cyst has not emanated in good results therefore it is not an option of treatment generally used. With regard to outcome a combination of treatme
肾棘球蚴(棘球蚴)囊肿是一种非常罕见的疾病,在世界棘球蚴流行地区偶尔有报道,鉴于极为罕见的全球旅行,它往往在非流行地区有报道。肾脏棘球蚴囊肿可表现为非特异性症状,包括:腰/侧疼痛或不适;腹痛;腰部或腹部的肿块;棘球蚴病;腹胀;减肥;其他非特异性症状。在棘球蚴病流行区居住或旅行过的历史,以及与包括狗在内的动物接触过的历史确实在提醒临床医生棘球蚴疾病的可能性方面发挥了重要作用,这是有用的。一般和系统检查可能是正常的,但可以发现腰部压痛和上腹部压痛,这可能与腰部或上腹部可触摸的肿块有关,也可能与此无关。常规血液学和生物化学血液检查的结果可能是正常的,但有时可能有嗜酸性粒细胞增多。尿液分析可显示棘球蚴尿。Casoni皮内试验结果呈阳性或棘球蚴血清学试验呈阳性,往往会提醒临床医生注意棘球蚴病。腹部和肾道的放射学成像,包括腹部的超声扫描、计算机断层扫描和磁共振扫描,将显示肾脏内的囊肿(最常见)或囊肿(偶尔),以及囊肿的大小和看起来正常的肾实质的数量,以及子囊肿的存在。此外,如果有肾积水或输尿管积水,放射学图像会显示出来。肾棘球蚴囊肿的治疗确实需要结合以下药物进行治疗:抗scolicidal药物周期,其中阿苯达唑是最常用的药物和。手术治疗可能包括:腹腔镜下棘球蚴引流术和囊肿周围切除术。腹腔镜肾部分切除术。腹腔镜肾切除术在极少数情况下切除整个肾脏。腹腔镜肾输尿管切除术,当输尿管也有棘球蚴时。棘球蚴囊肿的开放性外科引流和囊肿周围切除术。棘球蚴开放引流和部分肾切除术。棘球蚴开放引流和全肾切除术。如果有相关的输尿管棘球蚴囊肿,则进行棘球蚴开放引流和肾输尿管切除术。如果在其他地方(例如肝脏)有相关的棘球蚴囊肿,也会小心地切除该囊肿。除一例报告的单独使用阿苯达唑治疗效果良好外,未经手术单独使用抗绞痛药物治疗效果不佳,囊肿复发。单纯的棘球蚴抽吸并没有产生良好的效果,因此它不是通常使用的治疗方法。就结果而言,联合阿苯达唑治疗和完全切除肾棘球蚴而不从囊肿中溢出,确实可以获得良好的结果,并且不会复发。据报道,肾棘球蚴偶尔复发,这可能是由于囊肿切除不完全或囊肿内容物溢出,加上或减去没有服用足够的抗Scolicida药物,尽管一些患者在没有抗绞痛药物的情况下成功地单独切除了棘球蚴。
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引用次数: 0
A Future Life Requires a Super Immune System 未来的生活需要超级免疫系统
Pub Date : 2021-08-28 DOI: 10.31579/2690-1919/197
M. Mahmood
Despite the capabilities of the immune system to qualify for saving the host through its adaptive and performance capabilities, many disease-causing organisms have adapted in ways that ensure their persistence. This necessitates developing immune system enhancements which may require fundamental modifications that aren't limited to routine procedures.
尽管免疫系统有能力通过其适应能力和表现能力来拯救宿主,但许多致病生物已经以确保其持久性的方式进行了适应。这就需要开发免疫系统增强功能,这可能需要基本的修改,而不仅仅局限于常规程序。
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引用次数: 0
Cytotoxic Activities in Vitro of Flower Extracts of Three Species of Aloe Growing in Yemen: Aloe Rubroviolaceae, Aloe Vera and Aloe Sabaea, against Eleven Types of Cancer Cell Lines 叶门三种芦荟花提取物对11种癌细胞的体外细胞毒活性研究(英文
Pub Date : 2021-08-28 DOI: 10.31579/2690-1919/187
H. Al-Shamahy
Background and aims: Natural products, especially plant extracts, have opened up great opportunities in the field of drug progress due to their chemical variety. The genus Aloe has long been used for medicinal uses in countless parts of the world. This study was designed to investigate the phytochemicals and anti-cancer capabilities of Aloe rubroviolaceae, Aloe vera and Aloe sabaea flowers. Materials and Methods: The methanolic extracts of three types of plants traditionally used in Yemen to treat a variety of diseases have been tested in vitro for their potential anticancer activity on different human cancer cell lines. The cytotoxic activity of the methanolic extracts of tested plants was determined using eleven strains of human cancer cells, namely: MCF-7 (breast cancer), PC-3 (prostate cancer), HEP-2 (human epithelial carcinoma), MNFS-60 (myelogenous leukemia), CACO (intestinal cancer), A-549 (lung adenocarcinoma), HeLa (cervical cancer), RD (rhabdomyosarcoma),HepG2 (hepatocellular carcinoma), HCT-116 (colon cancer), and CHO-K1 (Chinese hamster ovary). A colorimetric sulforhodamine B assay was used to evaluate the in vitro cytotoxic activity of different extracts. Growth inhibition of 50% (IC50) for each extract was calculated from the optical density of treated and untreated cells. Doxorubicin, a broad-spectrum anticancer drug was used as a positive control. Results: More interesting cytotoxic activity was observed for Aloe vera extract more than Aloe sabaea and Aloe rubroviolaceae, extract. Conclusions: This study provides a preliminary screening for anti-proliferative activity of various Aloe species flowers extracts on different cancer cell lines. Different extracts of Aloe species significantly inhibit the growth of various cancer cell lines in a concentration-dependent manner. Further investigations are required to understand the possible mechanism(s) of action of these extract on various cancer cells and isolation of active phyto-chemicals.
背景和目的:天然产物,特别是植物提取物,由于其化学多样性,在药物开发领域开辟了巨大的机遇。芦荟属植物长期以来在世界各地被用于药用。本研究旨在研究红毛芦荟科、库拉索芦荟和sabaea芦荟花的植物化学成分和抗癌能力。材料和方法:也门传统上用于治疗多种疾病的三种植物的甲醇提取物已在体外测试其对不同人类癌症细胞系的潜在抗癌活性。使用11株人癌症细胞,即MCF-7(癌症)、PC-3(癌症)、HEP-2(人上皮癌)、MNFS-60(髓性白血病)、CACO(癌症肠)、A-549(肺腺癌)、HeLa(癌症子宫颈癌)、RD(横纹肌肉瘤)、HepG2(肝细胞癌)、,HCT-116(结肠癌)和CHO-K1(中国仓鼠卵巢)。采用磺基罗丹明B比色法测定不同提取物的体外细胞毒性活性。根据经处理和未经处理的细胞的光密度计算每种提取物50%的生长抑制(IC50)。阿霉素,一种广谱抗癌药物被用作阳性对照。结果:芦荟提取物的细胞毒活性比紫苏芦荟和红毛芦荟科的提取物更强。结论:本研究初步筛选了芦荟花提取物对不同癌症细胞株的抗增殖活性。芦荟的不同提取物以浓度依赖的方式显著抑制各种癌症细胞系的生长。需要进一步的研究来了解这些提取物对各种癌症细胞的可能作用机制和活性植物化学物质的分离。
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引用次数: 0
Neonatal Gallstones 新生儿胆结石
Pub Date : 2021-07-31 DOI: 10.31579/2690-1919/181
L. Mazur
A term male infant was born by spontaneous vaginal delivery to a 23 year old gravida 2 para 2 mother. His weight, length, and head circumference were 2720g (8%), 47cm (6%) and 31.5cm (1%) respectively; the remainder of his physical examination was unremarkable. The pregnancy was complicated by intra-uterine growth retardation, gestational diabetes controlled with glyburide, and gestational thrombocytopenia. The mother had a past medical history of obesity, BMI of 32 (>95%), HPV infection, and atypical squamous cells of the cervix. A fetal ultrasound at 38 weeks gestational age showed echogenic foci consistent with cholelithiasis (Figure 1); a previous US at 37 weeks gestational age was normal. On routine laboratory testing the mother’s blood type was O positive and the infant’s was A+ (positive). His transcutaneous bilirubin was 4.3 mg/dL at 36 hours of life. Both mother and son were discharged after two days without problem.
一名足月男婴由一名23岁的2段孕妇自然阴道分娩而生。他的体重、身长和头围分别为2720克(8%)、47厘米(6%)和31.5厘米(1%);他身体检查的剩余部分并不起眼。妊娠合并子宫内生长迟缓,妊娠期糖尿病用格列本脲控制,妊娠期血小板减少症。该母亲既往有肥胖、BMI为32(>95%)、HPV感染和宫颈非典型鳞状细胞病史。胎龄38周时的胎儿超声显示回声灶与胆结石一致(图1);孕龄37周时的既往超声检查是正常的。在常规实验室检测中,母亲的血型为O阳性,婴儿的血型为A+(阳性)。他的经皮胆红素在36小时时为4.3 mg/dL。两天后,母子俩都顺利出院。
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引用次数: 1
Yasser's COVID-19 Discrepancy Phenomenon; A Novel Phenomenon And Effective Regimen; Retrospective-Observational Study Yasser的COVID-19差异现象;一种新的现象和有效的治疗方案回顾性观察研究
Pub Date : 2021-07-31 DOI: 10.31579/2690-1919/185
Y. Elsayed
Aim of the study: Clarification for the time of the clinical improvement after management COVID-19 pneumonia versus normal gradation of common workup is the target for the current study. Background: COVID-19 pneumonia is a current serious international pandemic infection. Generally, in medical diseases, the clinical response is commonly parallel to laboratory and radiological improvement. This rule may be different in COVID-19 pneumonia. Method of study and patients: The author reported retrospective-observational 47-case report series. The study was conducted in a physician outpatient clinic thorough nearly 12-months, starting from Jun 9, 2020, and, ended on May 8, 2021. All included cases were COVID-19 pneumonia and treated with conventional antibiotics, anticoagulants, and steroids. Results: The mean ±SD age was: 50.08 (14.9) years, with male sex predominance (55.32%). The mean days of clinical versus leukocytosis, neutrophilia, and lymphopenia improvement (0.84 ±0.49, 13.05 ±6.44, 13.05 ±7.01, 13.05 ±7.01).The mean ±SD days of clinical versus CRP, D-dimer, s. ferritin, and LDH improvement (0.84 ±0.49, 12.2 ±3.25, 12.2 ±6.21, 12.3 ±5.46, 20.92± 9.48). The mean days of clinical versus radiological and electrocardiographic improvement (0.84 ±0.49, 15.74 ±5.25, 11.45 ±5.45). The test was statistically significant in all the above tests (p-value is < .00001) Conclusions: Yasser’s COVID-19 Discrepancy phenomenon is a novel descriptive phenomenon that is always seen in all COVID-19 pneumonia. Initial dramatic improvement of the clinical status of COVID-19 pneumonic patient, not a simultaneously after the management, not a coincide with laboratory, radiological, and electrocardiographic workup. Further larger studies for the study medical regimen with considering of “Yasser’s COVID-19 Discrepancy phenomenon” is recommended.
研究目的:澄清新冠肺炎肺炎治疗后临床改善的时间与普通检查的正常分级是当前研究的目标。背景:新冠肺炎肺炎是目前国际上一种严重的大流行性感染。一般来说,在医疗疾病中,临床反应通常与实验室和放射学改善平行。这一规则在新冠肺炎肺炎中可能有所不同。研究方法和患者:作者报告了47例回顾性观察病例报告系列。这项研究在一家医生门诊进行了近12个月,从2020年6月9日开始,到2021年5月8日结束。所有纳入病例均为新冠肺炎肺炎,并使用常规抗生素、抗凝血剂和类固醇进行治疗。结果:平均±SD年龄为:50.08(14.9)岁,男性占主导地位(55.32%)。临床与白细胞增多症、中性粒细胞增多症和淋巴细胞减少症改善的平均天数为(0.84±0.49、13.05±6.44、13.05士7.01、13.05徒7.01),和LDH改善(0.84±0.49,12.2±3.25,12.2±6.21,12.3±5.46,20.92±9.48总是在所有新冠肺炎肺炎中看到。新冠肺炎肺炎患者临床状况的初步显著改善,不是在管理后同时进行,也不是与实验室、放射学和心电图检查同时进行。考虑到“Yasser的新冠肺炎差异现象”,建议对研究医疗方案进行进一步的更大规模研究。
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引用次数: 0
Classical Soliton Theory for Studying the Dynamics and Evolution of in Network 研究网络动力学和进化的经典孤子理论
Pub Date : 2021-07-31 DOI: 10.31579/2690-1919/186
S. Belyakin
This paper presents the dynamic model ofthe soliton. Based on this model, it is supposed to study the state of the network. The term neural networks refersto the networks of neurons in the mammalian brain. Neurons are its main units of computation. In the brain, they are connected together in a network to process data. This can be a very complex task, and so the dynamics of neural networks in the mammalian brain in response to external stimuli can be quite complex. The inputs and outputs of each neuron change as a function of time, in the form of so-called spike chains, but the network itself also changes. We learn and improve our data processing capabilities by establishing reconnections between neurons.
本文给出了孤子的动力学模型。基于这个模型,它应该研究网络的状态。神经网络是指哺乳动物大脑中的神经元网络。神经元是它的主要计算单位。在大脑中,它们在一个网络中连接在一起,以处理数据。这可能是一项非常复杂的任务,因此哺乳动物大脑中神经网络对外部刺激的反应可能非常复杂。每个神经元的输入和输出都是时间的函数,以所谓的尖峰链的形式发生变化,但网络本身也会发生变化。我们通过在神经元之间建立重新连接来学习和提高我们的数据处理能力。
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引用次数: 0
Impact of COVID-19 on several industries in context with the Impact OF Covid-19 on Several Industries in Context with the Sperm Bank Industry 新冠肺炎对几个行业的影响与新冠肺炎对几个行业和精子库行业的影响
Pub Date : 2021-07-31 DOI: 10.31579/2690-1919/183
Ashish M. Gujrathi
COVID-19 is an infectious disease that originated in Hubei province of the Wuhan city in China in late December. The highly contagious disease, caused by a virus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is transmitted from humans to humans. After the first case in Wuhan, the disease rapidly spread to other parts of the globe. On March 11, 2020, the World Health Organization (WHO) made an assessment that COVID-19 can be characterized as a pandemic. Thus, social-distancing became an important measure to stop the spread of this disease. Various countries across the world adopted nationwide lockdown. This led to a completely new scenario for the world, where every business in each industry faced new challenges and witnessed new opportunities.
新冠肺炎是12月下旬起源于中国湖北武汉市的一种传染病。这种高度传染性疾病是由一种病毒引起的,即严重急性呼吸综合征冠状病毒2型(SARS-CoV-2),由人类传播给人类。在武汉出现首例病例后,这种疾病迅速蔓延到全球其他地区。2020年3月11日,世界卫生组织(世界卫生组织)作出评估,认为新冠肺炎可以被定性为大流行。因此,保持社交距离成为阻止这种疾病传播的重要措施。世界各地的国家都实行了全国封锁。这为世界带来了一个全新的场景,每个行业的每一家企业都面临着新的挑战,也见证了新的机遇。
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引用次数: 0
Ovarian Cystadenocarcinoma with an Osteosarcoma Component 卵巢囊腺癌伴骨肉瘤成分
Pub Date : 2021-07-24 DOI: 10.15520/ARJMCS.V7I07.347
Pr S. Sakhri esp Boulhart
Ovarian cystadenocarcinoma with an osteosarcoma component, is a very rare tumor. We aimed to describe a case of an osteosarcoma arising in an ovarian squamous cell carcinoma.
卵巢囊腺癌伴骨肉瘤,是一种非常罕见的肿瘤。我们的目的是描述一个病例骨肉瘤引起卵巢鳞状细胞癌。
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引用次数: 0
An Obstructive Prostatic Urethral Calculus in a Patient with Urethral Strictures: A Case Report 一例尿道狭窄患者的梗阻性前列腺尿道结石病例报告
Pub Date : 2021-06-24 DOI: 10.31579/2690-1919/178
Sule Mb
Urinary calculi are the third most common affliction of the urinary tract only exceeded by urinary tract infections and pathologies of the prostate gland. Urinary tract calculi contribute to a major concern encountered in the practice of urology, it affects about 10-12% of the population with a variable incidence with respect to sex, age, occupation, geographical area, climate, dietary fluid intake, social class and race. Urethral calculus is always found on the site of prostatic urethra, bulbar and fossa navicularis. Primary urethral calculi are usually associated with urethral strictures, posterior urethral valve and a diverticulum. Urethral calculi represent 1-2% of all calculi in the urinary tract. This is a case of a 32-year-old farmer and fisherman who had a retrograde urethrocystography (RUCG) that showed an obstructive prostatic calculus, bladder wall calcification and thickening with contrast refluxing into the seminal vesicles bilaterally.
尿路结石是尿路第三常见的疾病,仅次于尿路感染和前列腺病变。尿路结石是泌尿外科实践中遇到的一个主要问题,它影响着约10-12%的人口,其发病率因性别、年龄、职业、地理区域、气候、饮食液体摄入、社会阶层和种族而异。尿道结石常见于前列腺尿道、延髓和舟状窝。原发性尿道结石通常与尿道狭窄、尿道后瓣膜和憩室有关。尿道结石占尿路结石总数的1-2%。这是一个32岁的农民和渔民的病例,他进行了逆行尿道膀胱造影术(RUCG),显示梗阻性前列腺结石、膀胱壁钙化和增厚,造影剂回流到双侧精囊中。
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引用次数: 0
A Limit on Logic 逻辑的一个极限
Pub Date : 2021-06-24 DOI: 10.31579/2690-1919/176
James F. Welles
One of the problems with logic is that it cannot be self-refuting–if it is, it is not logical. This make logic its own sacred cow. It likewise makes the expression “By logical extension” irrelevant or at least suspect in a curved universe. One may extend logic, but even after one step, its use is dubious at best.
逻辑的一个问题是,它不能自我反驳——如果是,那就不符合逻辑。这使逻辑成为其神圣的奶牛。它同样使“通过逻辑延伸”这一表述在弯曲的宇宙中变得无关紧要,或者至少令人怀疑。人们可以扩展逻辑,但即使经过一步,它的使用充其量也是可疑的。
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引用次数: 0
期刊
Journal of clinical research and reports
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