Nadir A. Aliyev, Teymur A. Qafarov, Agahasan R. Rasulov, Eldar R. Hagverdi, Zafar N. Aliyev
Objective: The purpose of this study was a retrospective study of the contingent of schizophrenia patients who were most infected with COVID-19. Materials and Methods: We study 350 patients schizophrenia who infected with COVID-19 impact on the clinical picture and therapy of the illness. The investigation ware carried out in psychiatric hospital Ministry of Health of the Republic of Azerbaijan. The hospital has a capacity of 2000 beds. Results: Patients with schizophrenia who infected with COVID-19 in these clinically observed following changes: the intensity of psychopathological symptoms decreases, psychosomatic balancing occurs, that is, during the COVID-19 illness, schizophrenic symptoms fade into the background, practically become invisible. Conclusion: Patients schizophrenia who infected with COVID-19 in these clinically observed shows an improvement in their mental health.
{"title":"Impact of COVID-19 on the Clinical Picture and Therapy of Schizophrenia","authors":"Nadir A. Aliyev, Teymur A. Qafarov, Agahasan R. Rasulov, Eldar R. Hagverdi, Zafar N. Aliyev","doi":"10.31579/2690-1919/229","DOIUrl":"https://doi.org/10.31579/2690-1919/229","url":null,"abstract":"Objective: The purpose of this study was a retrospective study of the contingent of schizophrenia patients who were most infected with COVID-19. Materials and Methods: We study 350 patients schizophrenia who infected with COVID-19 impact on the clinical picture and therapy of the illness. The investigation ware carried out in psychiatric hospital Ministry of Health of the Republic of Azerbaijan. The hospital has a capacity of 2000 beds. Results: Patients with schizophrenia who infected with COVID-19 in these clinically observed following changes: the intensity of psychopathological symptoms decreases, psychosomatic balancing occurs, that is, during the COVID-19 illness, schizophrenic symptoms fade into the background, practically become invisible. Conclusion: Patients schizophrenia who infected with COVID-19 in these clinically observed shows an improvement in their mental health.","PeriodicalId":93114,"journal":{"name":"Journal of clinical research and reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49073073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: The dysfunction in sexual ability has effects on the quality of life in men. Oxytocin plays a role in sexual and social behaviors. Hyperprolactemic males had erectile dysfunction. Endogenous estrogens in men, are not only important for health integrity but can additionally cause the promotion of many diseases. Objectives: The current review aimed to high light on the role of oxytocin, prolactin, and estrogen in male sexual functions. Oxytocin neurons have been heavily implicated in mediating sexual behavior in both humans and animals. Oxytocin hormone regulates social behaviors such as mating, maternal/paternal care, and bonding. Oxytocin levels rise during mating in females and males in humans and animals and may mediate anxiolytic/calming effects of sexual activity and antidepressant effects.Oxytocin’s role in regulating erection and ejaculation has been studied in mice and rats. Oxytocinergic projections from the paraventricular nucleus to the hippocampus, medulla oblongata, and spinal cord facilitate penile erection. Prolactin (PRL) serves a dual function both as a circulatory hormone and as a cytokine. PRL is known to be involved in the control of male copulatory behavior in humans, mice, rats, and other rodent models. It release during copulation in males and has a positive modulation for various aspects of testicular functions which hinting at the crucial role of prolactin in male reproduction. The lower concentration of prolactin was associated with reduced seminal vesicle volume and ejaculate in the infertile human male. Hypoprolactinemia has been associated with premature ejaculation and erectile dysfunction. Hyperprolactinemia can be caused by tumors, drugs, or idiopathic, leading to alterations in sexual behavior as loss of libido and erectile dysfunction. It is also reported that it can cause endocrine disturbances leading to abnormal levels of testosterone, FSH, and LH. Chronic hyperprolactinaemia suppresses copulatory behaviour in animal models and yields sexual dysfunction and other side effects in men. In men, testosterone acting via its action on androgen receptors may be dependent on the action of aromatase enzyme on of testosterone and converting it to estradiol (E2). Estrogens act through ERα and ERβ at the plasma membrane and in the nucleus to regulate functions of many organs in men. The role of estradiol action on libido is seen at various levels of regulation, starting with direct effects in the brain. Not only does estradiol modulate sexual behavior in the adult male, it also appears to organize the early brain to program sexual behavior. The exact role of estradiol in each area of male sexual function including libido, spermatogenesis, and erectile function is difficult to determine. A complex balance of testosterone, estradiol, aromatase, and estrogen receptors in brain, testes, and penis, confirmed the indispensable and highly regulated hormonal interaction of estrogen in the male. Conclusion: It can be co
{"title":"The Role of Oxytocin, Prolactin, and Estrogen in Male Sexual Functions","authors":"Azab Elsayed Azab","doi":"10.31579/2690-1919/228","DOIUrl":"https://doi.org/10.31579/2690-1919/228","url":null,"abstract":"Background: The dysfunction in sexual ability has effects on the quality of life in men. Oxytocin plays a role in sexual and social behaviors. Hyperprolactemic males had erectile dysfunction. Endogenous estrogens in men, are not only important for health integrity but can additionally cause the promotion of many diseases. Objectives: The current review aimed to high light on the role of oxytocin, prolactin, and estrogen in male sexual functions. Oxytocin neurons have been heavily implicated in mediating sexual behavior in both humans and animals. Oxytocin hormone regulates social behaviors such as mating, maternal/paternal care, and bonding. Oxytocin levels rise during mating in females and males in humans and animals and may mediate anxiolytic/calming effects of sexual activity and antidepressant effects.Oxytocin’s role in regulating erection and ejaculation has been studied in mice and rats. Oxytocinergic projections from the paraventricular nucleus to the hippocampus, medulla oblongata, and spinal cord facilitate penile erection. Prolactin (PRL) serves a dual function both as a circulatory hormone and as a cytokine. PRL is known to be involved in the control of male copulatory behavior in humans, mice, rats, and other rodent models. It release during copulation in males and has a positive modulation for various aspects of testicular functions which hinting at the crucial role of prolactin in male reproduction. The lower concentration of prolactin was associated with reduced seminal vesicle volume and ejaculate in the infertile human male. Hypoprolactinemia has been associated with premature ejaculation and erectile dysfunction. Hyperprolactinemia can be caused by tumors, drugs, or idiopathic, leading to alterations in sexual behavior as loss of libido and erectile dysfunction. It is also reported that it can cause endocrine disturbances leading to abnormal levels of testosterone, FSH, and LH. Chronic hyperprolactinaemia suppresses copulatory behaviour in animal models and yields sexual dysfunction and other side effects in men. In men, testosterone acting via its action on androgen receptors may be dependent on the action of aromatase enzyme on of testosterone and converting it to estradiol (E2). Estrogens act through ERα and ERβ at the plasma membrane and in the nucleus to regulate functions of many organs in men. The role of estradiol action on libido is seen at various levels of regulation, starting with direct effects in the brain. Not only does estradiol modulate sexual behavior in the adult male, it also appears to organize the early brain to program sexual behavior. The exact role of estradiol in each area of male sexual function including libido, spermatogenesis, and erectile function is difficult to determine. A complex balance of testosterone, estradiol, aromatase, and estrogen receptors in brain, testes, and penis, confirmed the indispensable and highly regulated hormonal interaction of estrogen in the male. Conclusion: It can be co","PeriodicalId":93114,"journal":{"name":"Journal of clinical research and reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43785062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sule Mb, Shamaki Amb, Umar Au, Gele Ih, Ribah Mm, Aliyu Az
Gallstones present as acute calculus cholecystitis in about 20% of individuals with symptomatic disease, having a wide range of symptom severity. The adult population is most often affected in about 10-15% within the developed countries. This is a 75-year-old man that was referred for a confirmatory ultrasonography from a peripheral health centre on account of an entertained ileocecal tumor following an abdominal ultrasound scan done in a local health care facility. The patient had an abdominal ultrasonography that showed an impacted calculus in the infundibulum of the gallbladder measuring about 30mm x 30mm in dimension with associated distended gall bladder; this shows thick and trabeculated wall, heterogenous content with circumferential hypoechoic halo of acute cholecystitis. The patient had percutaneous cholecystectomy in the peripheral care facility and was reported to have done considerably well for discharge. We report the ultrasonographic findings of acute calculus cholecystitis due to its peculiarity and presentations.
{"title":"Acute Calculus Cholecystitis Misdiagnosed As Ileocecal Tumor in an Elderly Male: Review of the Ultrasonographic Findings: A Case Report","authors":"Sule Mb, Shamaki Amb, Umar Au, Gele Ih, Ribah Mm, Aliyu Az","doi":"10.31579/2690-1919/223","DOIUrl":"https://doi.org/10.31579/2690-1919/223","url":null,"abstract":"Gallstones present as acute calculus cholecystitis in about 20% of individuals with symptomatic disease, having a wide range of symptom severity. The adult population is most often affected in about 10-15% within the developed countries. This is a 75-year-old man that was referred for a confirmatory ultrasonography from a peripheral health centre on account of an entertained ileocecal tumor following an abdominal ultrasound scan done in a local health care facility. The patient had an abdominal ultrasonography that showed an impacted calculus in the infundibulum of the gallbladder measuring about 30mm x 30mm in dimension with associated distended gall bladder; this shows thick and trabeculated wall, heterogenous content with circumferential hypoechoic halo of acute cholecystitis. The patient had percutaneous cholecystectomy in the peripheral care facility and was reported to have done considerably well for discharge. We report the ultrasonographic findings of acute calculus cholecystitis due to its peculiarity and presentations.","PeriodicalId":93114,"journal":{"name":"Journal of clinical research and reports","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70018429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. Panahi, Mania Khalilpour Darestani, M. Anbari, Keyhan Javanmardi
Background and Objective (s): Premenstrual syndrome (PMS) refers to a group of physical, behavioral, and mood symptoms that appear about a week or two before menstruation begins. Given the prevalence of this syndrome among adolescents and young women, this study was performed with the aim of determining the predictors of adoption of preventive behaviors of PMS using the Health Belief Model (HBM) among female teenagers. Materials and Methods: This cross-sectional-analytical study was conducted among 240 pre-university girl students of Tehran, Iran in 2016. The sampling was performed using multi-stage random sampling. The data collection tool was a demographic information, a valid and reliable questionnaire available including PMS preventive behaviors and all constructs of HBM. The data were collected and then entered into SPSS software version 16 and analyzed using Pearson correlation coefficient, multiple regression tests and descriptive statistics. Results: The participated students obtained 38.5% of the score for the adoption of preventive behaviors of PMS. The three constructs of perceived barriers, perceived susceptibility and self-efficacy were predictors of adoption of preventive behaviors of PMS. Overall, these constructs were able to predict 32.6% of the behavioral changes. Conclusion: According to the results of this study, in the design and implementation of educational interventions should emphasize the constructs of perceived susceptibility, perceived barriers and self-efficacy as the most important predictors of adoption of preventive behaviors of PMS among Female Teenagers.
{"title":"Predictors of Adoption of Preventive Behaviors of Premenstrual Syndrome Based on Health Belief Model among Female Teenagers","authors":"R. Panahi, Mania Khalilpour Darestani, M. Anbari, Keyhan Javanmardi","doi":"10.31579/2690-1919/225","DOIUrl":"https://doi.org/10.31579/2690-1919/225","url":null,"abstract":"Background and Objective (s): Premenstrual syndrome (PMS) refers to a group of physical, behavioral, and mood symptoms that appear about a week or two before menstruation begins. Given the prevalence of this syndrome among adolescents and young women, this study was performed with the aim of determining the predictors of adoption of preventive behaviors of PMS using the Health Belief Model (HBM) among female teenagers. Materials and Methods: This cross-sectional-analytical study was conducted among 240 pre-university girl students of Tehran, Iran in 2016. The sampling was performed using multi-stage random sampling. The data collection tool was a demographic information, a valid and reliable questionnaire available including PMS preventive behaviors and all constructs of HBM. The data were collected and then entered into SPSS software version 16 and analyzed using Pearson correlation coefficient, multiple regression tests and descriptive statistics. Results: The participated students obtained 38.5% of the score for the adoption of preventive behaviors of PMS. The three constructs of perceived barriers, perceived susceptibility and self-efficacy were predictors of adoption of preventive behaviors of PMS. Overall, these constructs were able to predict 32.6% of the behavioral changes. Conclusion: According to the results of this study, in the design and implementation of educational interventions should emphasize the constructs of perceived susceptibility, perceived barriers and self-efficacy as the most important predictors of adoption of preventive behaviors of PMS among Female Teenagers.","PeriodicalId":93114,"journal":{"name":"Journal of clinical research and reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46840787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Livedo is an ischemic dermopathy caused by vasculopathies or prothrombotic states, and characterized by the violaceous lace-like mottling of the skin. We report on a patient who developed livedo reticularis – livedo racemosa overlap syndrome as a late sequel of erysipelas, the livedo being restricted to the limb segment affected earlier by erysipelas and devoid of systemic vasculopathy. Though erysipelas and livedo are common disorders, we could not find in the literature reports of an occurrence like that observed in this patient. In this case a favorable prognosis of livedo could be predicted. In a different context, livedo may be the alarming signal of an undiagnosed systemic disease.
{"title":"Livedo of the Forearm in the Aftermath of Forearm Erysipelas","authors":"Jochanan E. Naschitz","doi":"10.31579/2690-1919/216","DOIUrl":"https://doi.org/10.31579/2690-1919/216","url":null,"abstract":"Livedo is an ischemic dermopathy caused by vasculopathies or prothrombotic states, and characterized by the violaceous lace-like mottling of the skin. We report on a patient who developed livedo reticularis – livedo racemosa overlap syndrome as a late sequel of erysipelas, the livedo being restricted to the limb segment affected earlier by erysipelas and devoid of systemic vasculopathy. Though erysipelas and livedo are common disorders, we could not find in the literature reports of an occurrence like that observed in this patient. In this case a favorable prognosis of livedo could be predicted. In a different context, livedo may be the alarming signal of an undiagnosed systemic disease.","PeriodicalId":93114,"journal":{"name":"Journal of clinical research and reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45316490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Cerebral palsy is a heterogeneous disorder that can cause a lifelong disability that is associated with a non-progressive damage in the brain. It is commonly caused by antenatal, perinatal, early postnatal and neonatal conditions. However, post-neonatal cases of acquired cerebral palsy have also been reported, and were commonly caused by infection. Patients and Methods: The family of a girl from Qatar, who developed severe cerebral palsy caused by submersion injury, consulted us about the possible therapies for her condition. Clinical picture and brain imaging abnormalities are described, and the relevant literatures were reviewed with the aim of suggesting possible evidence-based therapies. Results: At the age of 23 months, a previously healthy girl developed anoxic encephalopathy after experiencing submersion injury. MRI showed evidence of significant hypoxic ischemic injury primarily affecting the deep grey matter, hippocami, mid-brain and the posterior cortex. EEG showed diffuse slowness of cerebral activity and diffuse attenuation of the background without no epileptic abnormalities suggesting diffuse encephalopathy resulting from diffuse cortical injury. At the about age of three and half years, her family consulted us about her condition as she was still showing no awareness to the environment, showing no significant spontaneous movements. She had poor head control. Unable to sit or stand alone, and had a flexed posture. She was on levetiracetam (Keppra), diazepam, and baclofen 30 mg daily. She was still having tracheotomy, and was fed through gastrostomy tube. Conclusion: In this paper, the rare occurrence of severe post-infantile cerebral palsy is described. Emphasis is made on the possibility of using evidence-based multi-factorial therapies in cerebral palsy.
{"title":"A Girl from Qatar with Post-Infantile Acquired Cerebral Palsy Caused By Submersion Injury: A Rare Etiology and a Therapeutic-Challenge.","authors":"Aamir Jalal Al-Mosawi","doi":"10.31579/2690-1919/222","DOIUrl":"https://doi.org/10.31579/2690-1919/222","url":null,"abstract":"Background: Cerebral palsy is a heterogeneous disorder that can cause a lifelong disability that is associated with a non-progressive damage in the brain. It is commonly caused by antenatal, perinatal, early postnatal and neonatal conditions. However, post-neonatal cases of acquired cerebral palsy have also been reported, and were commonly caused by infection. Patients and Methods: The family of a girl from Qatar, who developed severe cerebral palsy caused by submersion injury, consulted us about the possible therapies for her condition. Clinical picture and brain imaging abnormalities are described, and the relevant literatures were reviewed with the aim of suggesting possible evidence-based therapies. Results: At the age of 23 months, a previously healthy girl developed anoxic encephalopathy after experiencing submersion injury. MRI showed evidence of significant hypoxic ischemic injury primarily affecting the deep grey matter, hippocami, mid-brain and the posterior cortex. EEG showed diffuse slowness of cerebral activity and diffuse attenuation of the background without no epileptic abnormalities suggesting diffuse encephalopathy resulting from diffuse cortical injury. At the about age of three and half years, her family consulted us about her condition as she was still showing no awareness to the environment, showing no significant spontaneous movements. She had poor head control. Unable to sit or stand alone, and had a flexed posture. She was on levetiracetam (Keppra), diazepam, and baclofen 30 mg daily. She was still having tracheotomy, and was fed through gastrostomy tube. Conclusion: In this paper, the rare occurrence of severe post-infantile cerebral palsy is described. Emphasis is made on the possibility of using evidence-based multi-factorial therapies in cerebral palsy.","PeriodicalId":93114,"journal":{"name":"Journal of clinical research and reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47662449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The modern technological advancements and facilities have made people welcome medical equipment to home. Most common home medical equipment include glucometer, automated external defibrillators, blood glucose monitors, blood pressure monitors, halter monitors, mobility devices, weighing scale and so on. These equipment can provide safe, convenient, cost-effective, and suitable treatments to patients at home.
{"title":"Home Medical Equipment is Highly Being Adopted in U.S. – Explore Why?","authors":"Ashish M. Gujrathi","doi":"10.31579/2690-1919/221","DOIUrl":"https://doi.org/10.31579/2690-1919/221","url":null,"abstract":"The modern technological advancements and facilities have made people welcome medical equipment to home. Most common home medical equipment include glucometer, automated external defibrillators, blood glucose monitors, blood pressure monitors, halter monitors, mobility devices, weighing scale and so on. These equipment can provide safe, convenient, cost-effective, and suitable treatments to patients at home.","PeriodicalId":93114,"journal":{"name":"Journal of clinical research and reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46414090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Pyar, S. Hlaing, A. Aung, Z. Aung, N. L. Maung, K. Myat, K. Lwin, L. Maung, Ye Min Hein, Lynn Htet Aung, Chan Pyae Aung, Moe Tun Zaw, M. Maung, A. Kyaw, Thurein Win, Kyaw Zay Ya, Myo Thant Kyaw, Z. Oo, Zay Phyo Aung, A. Thu
A young man presented with abdominal pain and vomiting after eating Naphthalene Mothball. He had dyspnea, central cyanosis (SaO2 on air was 67% on air), marked pallor, deep jaundice and dehydration. His urine color was black; and, his plasma in clotted blood sample was brownish. He was treated as methemoglobinemia due to suicidal Naphthalene Mothball poisoning with fluid and electrolyte replacement, ascorbic acid, N-acetylcystine and exchange transfusion twice with four units of whole blood. Dramatic improvement in central cyanosis immediately following exchange transfusion. Psychiatric consultation and counselling were done; he admitted the main reason for committing suicide was socioeconomic stress due to COVID-19.
{"title":"COVID-19 and Stress: A Young Male Presenting with Central Cyanosis, Dark Urine, Oliguria, Jaundice and Anemia due to Methemoglobinemia as a result of Suicidal Naphthalene Mothball Poisoning Recovered with Exchange Transfusion","authors":"K. Pyar, S. Hlaing, A. Aung, Z. Aung, N. L. Maung, K. Myat, K. Lwin, L. Maung, Ye Min Hein, Lynn Htet Aung, Chan Pyae Aung, Moe Tun Zaw, M. Maung, A. Kyaw, Thurein Win, Kyaw Zay Ya, Myo Thant Kyaw, Z. Oo, Zay Phyo Aung, A. Thu","doi":"10.31579/2690-1919/217","DOIUrl":"https://doi.org/10.31579/2690-1919/217","url":null,"abstract":"A young man presented with abdominal pain and vomiting after eating Naphthalene Mothball. He had dyspnea, central cyanosis (SaO2 on air was 67% on air), marked pallor, deep jaundice and dehydration. His urine color was black; and, his plasma in clotted blood sample was brownish. He was treated as methemoglobinemia due to suicidal Naphthalene Mothball poisoning with fluid and electrolyte replacement, ascorbic acid, N-acetylcystine and exchange transfusion twice with four units of whole blood. Dramatic improvement in central cyanosis immediately following exchange transfusion. Psychiatric consultation and counselling were done; he admitted the main reason for committing suicide was socioeconomic stress due to COVID-19.","PeriodicalId":93114,"journal":{"name":"Journal of clinical research and reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44775882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bacteria possess an EF-Tu-based cytoskeleton.This article presents a short review. A number of questions which are not discussed in the former publications can be asked, such as: all bacteria possess a ribosomal protein synthesis system and, hence, also EF-Tu. EF-Tu is produced in an amount that is higher than the need for a function as translation elogation factor in ribsomal protein synthesis. This article tries to answer the question regarding the surplus of EF-Tu: formation of a "cell-wide web" by self-assembly as a feafure that stabilizes cell integrity. An additional question can be asked: what is the origin of this bacterial cytoskeleton? This article contains a speculation on this topic. A third question regards the'ntteructjon of ribosomes in the process of protemsynthesis: does the EF-Tu protein move to the ribosome, or does the ribosome move to the EF-Tu intergated in a fibril of the bacterial cytoskeleton? The former publication depicts electron micrographs which show colocalizatton of botth entities. EF-Tu is an example for aprotein with two independent functions: participation in the ribosomal protein synthesis as a kanslation elongation factor, and component of a bacterial cytoskeleton. This situation can open up a discussion ofthe sequence of events and states of early cells during evolution.
{"title":"The Bacterial Cytoskeleton based on Bacterial Translation Elongation Factor EF-Tu: Novel Insights","authors":"F. Mayer","doi":"10.31579/2690-1919/224","DOIUrl":"https://doi.org/10.31579/2690-1919/224","url":null,"abstract":"Bacteria possess an EF-Tu-based cytoskeleton.This article presents a short review. A number of questions which are not discussed in the former publications can be asked, such as: all bacteria possess a ribosomal protein synthesis system and, hence, also EF-Tu. EF-Tu is produced in an amount that is higher than the need for a function as translation elogation factor in ribsomal protein synthesis. This article tries to answer the question regarding the surplus of EF-Tu: formation of a \"cell-wide web\" by self-assembly as a feafure that stabilizes cell integrity. An additional question can be asked: what is the origin of this bacterial cytoskeleton? This article contains a speculation on this topic. A third question regards the'ntteructjon of ribosomes in the process of protemsynthesis: does the EF-Tu protein move to the ribosome, or does the ribosome move to the EF-Tu intergated in a fibril of the bacterial cytoskeleton? The former publication depicts electron micrographs which show colocalizatton of botth entities. EF-Tu is an example for aprotein with two independent functions: participation in the ribosomal protein synthesis as a kanslation elongation factor, and component of a bacterial cytoskeleton. This situation can open up a discussion ofthe sequence of events and states of early cells during evolution.","PeriodicalId":93114,"journal":{"name":"Journal of clinical research and reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42512174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. Shrivastava, R. Shrivastava, Nathalie Maneby, G. Giroir, Marjorie Georges, A. Bhatt
Background: Pollution induced allergic rhinitis and respiratory symptoms is becoming a major health problem in the world for which still there is no safe and preventive treatment. Objectives: Conceive and evaluate the allergen preventive properties and clinical efficacy of an osmotic, polymeric, stable filmogen spray, called PCNS. Materials and Methods: Amb A 1 (ragweed), Der P 1 and 2 (dust mite), Bet v 1 (birch), Alt a 1 (Alternaria, fungus), and Fel d 1 (cat dander) allergens were exposed at a concentration of 5µg/ml (20 µl per tube) on the polymeric test product film (120 and 240µl layer) and the allergens crossing the barrier were quantified in the agar gel beneath the film. 0.40% HPMC and PBS solutions, tested identically, served as controls. Clinical efficacy of PCNS nasal spray was evaluated in patients suffering from allergic rhinitis and/or respiratory symptoms (29 in test product v/s 15 in saline controls) for 22 days. Nasal, ocular, respiratory symptoms and Rhino conjunctivitis Quality of Life Questionnaire (RQLQ) were measured. Statistical analyses: The normality of the populations was determined by the Shapiro-Wilk test, then statistical analysis was performed by two-tailed Student’s test for comparisons between two groups and the two-way ANOVA followed by the post hoc Bonferroni’s test for comparisons of multiple groups. p<0.05 was considered statistically significant. The analyses were performed with the software GraphPad Prism (version 8.4.2, La Jolla, USA). NS indicates not significant. Results: PCNS polymeric spray blocked the diffusion of all the allergens while 0.40% HPMC was able to prevent diffusion of only Alt a 1 and Fel d 1 allergens. Mean reflective total nasal symptom scores (rTNSS), reflective total ocular symptom score (rTOSS), and respiratory symptoms including effect on wheezing, cough, dyspnea, and chest tightness were moderately improved in the control saline group, but the improvements were nearly twice better in the PCNS group. RQLQ was improved by 23% in saline spray v/s 46% PCNS group. 4/15 patients in saline group v/s 1/29 in PCNS group required rescue medication during the study. PCNS was highly effective in reducing allergen and pollution induced respiratory symptoms. Conclusion: a polymeric, osmotic, and stable nasal barrier against pollutants and allergens represents an innovative approach against pollution induced respiratory symptoms.
{"title":"Conception and Clinical Efficacy of an Osmotic, Polymeric, Stable Nasal Filmogen Barrier for Preventive Treatment of Allergen and Pollution Induced Rhinitis and Respiratory Symptoms","authors":"R. Shrivastava, R. Shrivastava, Nathalie Maneby, G. Giroir, Marjorie Georges, A. Bhatt","doi":"10.31579/2690-1919/219","DOIUrl":"https://doi.org/10.31579/2690-1919/219","url":null,"abstract":"Background: Pollution induced allergic rhinitis and respiratory symptoms is becoming a major health problem in the world for which still there is no safe and preventive treatment. Objectives: Conceive and evaluate the allergen preventive properties and clinical efficacy of an osmotic, polymeric, stable filmogen spray, called PCNS. Materials and Methods: Amb A 1 (ragweed), Der P 1 and 2 (dust mite), Bet v 1 (birch), Alt a 1 (Alternaria, fungus), and Fel d 1 (cat dander) allergens were exposed at a concentration of 5µg/ml (20 µl per tube) on the polymeric test product film (120 and 240µl layer) and the allergens crossing the barrier were quantified in the agar gel beneath the film. 0.40% HPMC and PBS solutions, tested identically, served as controls. Clinical efficacy of PCNS nasal spray was evaluated in patients suffering from allergic rhinitis and/or respiratory symptoms (29 in test product v/s 15 in saline controls) for 22 days. Nasal, ocular, respiratory symptoms and Rhino conjunctivitis Quality of Life Questionnaire (RQLQ) were measured. Statistical analyses: The normality of the populations was determined by the Shapiro-Wilk test, then statistical analysis was performed by two-tailed Student’s test for comparisons between two groups and the two-way ANOVA followed by the post hoc Bonferroni’s test for comparisons of multiple groups. p<0.05 was considered statistically significant. The analyses were performed with the software GraphPad Prism (version 8.4.2, La Jolla, USA). NS indicates not significant. Results: PCNS polymeric spray blocked the diffusion of all the allergens while 0.40% HPMC was able to prevent diffusion of only Alt a 1 and Fel d 1 allergens. Mean reflective total nasal symptom scores (rTNSS), reflective total ocular symptom score (rTOSS), and respiratory symptoms including effect on wheezing, cough, dyspnea, and chest tightness were moderately improved in the control saline group, but the improvements were nearly twice better in the PCNS group. RQLQ was improved by 23% in saline spray v/s 46% PCNS group. 4/15 patients in saline group v/s 1/29 in PCNS group required rescue medication during the study. PCNS was highly effective in reducing allergen and pollution induced respiratory symptoms. Conclusion: a polymeric, osmotic, and stable nasal barrier against pollutants and allergens represents an innovative approach against pollution induced respiratory symptoms.","PeriodicalId":93114,"journal":{"name":"Journal of clinical research and reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46280927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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