Pub Date : 2021-10-30DOI: 10.20473/bhsj.v4i2.26619
Putri Ayu Ika Setiyowati, Rofiatun Solekha, Srijaya Negara, R. Rosalina
Introduction: In humans, Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2) can damage some tissue when the immune systems was decrease. Natural product from the plant often used to improve immune response against microorganism including virus. This study aimed to determine the potential antioxidant of lemongrass extract (C . nardus) with various dosage that can provide immunomodulatory effects and find an optimal dosage to be used. Methods: The method used observasional analytic, using animal model of 30 male mice strain BALB/C, weight 25-30 gram, divided into 5 groups; the positive control group was given 0.05 mL of 0.05% CMC within 14 days, negative control group was given IMBOOST® tablet 200 mg/kg body weight (bw) within 14 days, treatment groups were given C. nardus extract with various doses 50 mg/kg bw, 150 mg/kg bw, and 300 mg/kg bw. In day 21 all group were injected with 0,2 ml of pathogen bacterial (S. aureus). Blood samples were taken three times: 7th day, 14th day, and 21th day. Results: The results showed that lemongrass extract (C. nardus) was able to influence the leukocyte and lymphocytes count with significant different (p<0.05). The optimal dose is 150 mg/kg body weight. Conclusion: The antioxidant compounds that contain in the C. nardus extract have an ability to increasing the immune system in the dose 150 mg/kg bw , but in the dose 300 mg/kg bw became toxic that can make a skin injury or death in animal test.
{"title":"Immunomodulator Effect of Lemongrass Extract (Cymbopogon nardus L.) to Increase Immune Cells as a Precaution Against SARS-CoV-2","authors":"Putri Ayu Ika Setiyowati, Rofiatun Solekha, Srijaya Negara, R. Rosalina","doi":"10.20473/bhsj.v4i2.26619","DOIUrl":"https://doi.org/10.20473/bhsj.v4i2.26619","url":null,"abstract":"Introduction: In humans, Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2) can damage some tissue when the immune systems was decrease. Natural product from the plant often used to improve immune response against microorganism including virus. This study aimed to determine the potential antioxidant of lemongrass extract (C . nardus) with various dosage that can provide immunomodulatory effects and find an optimal dosage to be used. Methods: The method used observasional analytic, using animal model of 30 male mice strain BALB/C, weight 25-30 gram, divided into 5 groups; the positive control group was given 0.05 mL of 0.05% CMC within 14 days, negative control group was given IMBOOST® tablet 200 mg/kg body weight (bw) within 14 days, treatment groups were given C. nardus extract with various doses 50 mg/kg bw, 150 mg/kg bw, and 300 mg/kg bw. In day 21 all group were injected with 0,2 ml of pathogen bacterial (S. aureus). Blood samples were taken three times: 7th day, 14th day, and 21th day. Results: The results showed that lemongrass extract (C. nardus) was able to influence the leukocyte and lymphocytes count with significant different (p<0.05). The optimal dose is 150 mg/kg body weight. Conclusion: The antioxidant compounds that contain in the C. nardus extract have an ability to increasing the immune system in the dose 150 mg/kg bw , but in the dose 300 mg/kg bw became toxic that can make a skin injury or death in animal test.","PeriodicalId":9324,"journal":{"name":"Biomolecular and Health Science Journal","volume":"120 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91473891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-30DOI: 10.20473/bhsj.v4i2.28933
H. M. Salim, Marinda Dwi Puspitarini, Yuani Setiwati, M. Shimabukuro
Introduction: Kratom (Mitragyna speciosa) is a tropical herbal plant native to the North Malay Peninsula, Malaysia and Thailand. In Indonesia, kratom us a typical plant of West Kalimantan, especially in Putussibau. Kratom leaf has many pharmacological effects, one of them is antioxidant. However, the antioxidant and antimicrobial activities of Mitragyna speciosa leaf extracts are lacking. This study was to examine the effect of the methanol extract of Mitragyna speciosa (Rubiaceae Family) leaves on microorganisms Escherichia coli and Strepococcus pneumoniae.Methods: Kratom leaves were extracted with methanol as solvent. In this study, S. pneumoniae and E. coli bacteria have been used. Antibacterial activity tests were carried out at concentrations of 0.78%, 1.56%, 3.125%, 6.25%, 12.5%, 25%, 50% and 100%. Insilico was used to search for secondary metabolites and metabolite interactions in Mytragina speciosa. Results: Mitragyna speciosa leaf methanol extract was effective in inhibiting the growth of E. coli and S. pneumoniae significantly (P<0.001). The growth of e.coli was not identified from a concentration of 25% to 100%. However, there was no bacterial growth in S. pneumoniae from a concentration of 6.25% to 100%. In the insilico study it was found that the secondary metabolite of Mitragyna speciosa is quercetin, which interacts with the ATP1 protein as a predictor in the mechanism of Mitragyna speciosa as an antibacterial. Conclusion: In conclusion, there is no correlation between nutritional status and remission outcome of patients with ALL in the induction phase of therapy. However, high percentage of underweight patients shows nutrition needs special attention to improve therapy outcomes.
{"title":"Antibacterial mechanism of Kratom (Mitragyna speciosa) methanol extract on Streptococcus pneumoniae and Eschericia coli bacteria","authors":"H. M. Salim, Marinda Dwi Puspitarini, Yuani Setiwati, M. Shimabukuro","doi":"10.20473/bhsj.v4i2.28933","DOIUrl":"https://doi.org/10.20473/bhsj.v4i2.28933","url":null,"abstract":"Introduction: Kratom (Mitragyna speciosa) is a tropical herbal plant native to the North Malay Peninsula, Malaysia and Thailand. In Indonesia, kratom us a typical plant of West Kalimantan, especially in Putussibau. Kratom leaf has many pharmacological effects, one of them is antioxidant. However, the antioxidant and antimicrobial activities of Mitragyna speciosa leaf extracts are lacking. This study was to examine the effect of the methanol extract of Mitragyna speciosa (Rubiaceae Family) leaves on microorganisms Escherichia coli and Strepococcus pneumoniae.Methods: Kratom leaves were extracted with methanol as solvent. In this study, S. pneumoniae and E. coli bacteria have been used. Antibacterial activity tests were carried out at concentrations of 0.78%, 1.56%, 3.125%, 6.25%, 12.5%, 25%, 50% and 100%. Insilico was used to search for secondary metabolites and metabolite interactions in Mytragina speciosa. Results: Mitragyna speciosa leaf methanol extract was effective in inhibiting the growth of E. coli and S. pneumoniae significantly (P<0.001). The growth of e.coli was not identified from a concentration of 25% to 100%. However, there was no bacterial growth in S. pneumoniae from a concentration of 6.25% to 100%. In the insilico study it was found that the secondary metabolite of Mitragyna speciosa is quercetin, which interacts with the ATP1 protein as a predictor in the mechanism of Mitragyna speciosa as an antibacterial. Conclusion: In conclusion, there is no correlation between nutritional status and remission outcome of patients with ALL in the induction phase of therapy. However, high percentage of underweight patients shows nutrition needs special attention to improve therapy outcomes.","PeriodicalId":9324,"journal":{"name":"Biomolecular and Health Science Journal","volume":"53 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85480085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-30DOI: 10.20473/bhsj.v4i2.30029
Dian Maharani, Hermina Novida
Diabetes mellitus (DM) is a chronic disease with an increasing frequency over the last decade. DM patient has higher risk of infection than people without diabetes. Several literatures suggest a strong positive correlation between hyperglycemia and skin infections. Skin and soft tissue infections (SSTIs), including abscess which commonly caused by Staphylococcus aureus, could lead to severe and life-threatening infections. The correct diagnosis and effective management therapy should be needed to prevent further complications and reduce morbidity and mortality. We report a case about facial abscess caused by S. aureus in diabetic patient that healed after got incision drainage and antibiotics.
{"title":"Facial Abscess due to Staphylococcus aureus in Patient with Type 2 Diabetes Mellitus: Case Report","authors":"Dian Maharani, Hermina Novida","doi":"10.20473/bhsj.v4i2.30029","DOIUrl":"https://doi.org/10.20473/bhsj.v4i2.30029","url":null,"abstract":"Diabetes mellitus (DM) is a chronic disease with an increasing frequency over the last decade. DM patient has higher risk of infection than people without diabetes. Several literatures suggest a strong positive correlation between hyperglycemia and skin infections. Skin and soft tissue infections (SSTIs), including abscess which commonly caused by Staphylococcus aureus, could lead to severe and life-threatening infections. The correct diagnosis and effective management therapy should be needed to prevent further complications and reduce morbidity and mortality. We report a case about facial abscess caused by S. aureus in diabetic patient that healed after got incision drainage and antibiotics.","PeriodicalId":9324,"journal":{"name":"Biomolecular and Health Science Journal","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88146497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-30DOI: 10.20473/bhsj.v4i1.24432
Rexel Kuatama, Louis Fabio Jonathan Jusni, Christa Karina
Background: Chronic Obstructive Pulmonary Disease (COPD) is the third highest leading cause of early death amongst other non-communicable diseases characterized by irreversible limitations of airflow. Current reliable classification relies on forced expiratory volume in the first second (FEV1) and forced vital capacity (FVC) measured on spirometry. In order to provide more effective and individualized management, new markers are needed. Accumulating studies has shown the role of miRNA in the pathogenesis of COPD and the progression of the disease. Aim: This review aims to provide overview of the diagnostic capabilities of miRNA and identify gaps of knowledge for further studies. Method: A review based on Preferred Reporting Items for Systematic Reviews and Meta Analyses (PRISMA) was conducted with the database from Pubmed, Science Direct, and Proquest. Outcome: A total of nine studies has reported diagnostic accuracies of miRNA in distinguishing COPD and normal, COPD and AECOPD, and other subtypes of COPD Conclusion: Retrospective diagnostic analyses of miRNAs have shown several promising AUC and need to be followed up with reliable prospective designs. Further diagnostics studies, in particular those with clinical values, need to be conducted.
{"title":"A review of miRNAs accuracy as a diagnostic biomarker in COPD patients","authors":"Rexel Kuatama, Louis Fabio Jonathan Jusni, Christa Karina","doi":"10.20473/bhsj.v4i1.24432","DOIUrl":"https://doi.org/10.20473/bhsj.v4i1.24432","url":null,"abstract":"Background: Chronic Obstructive Pulmonary Disease (COPD) is the third highest leading cause of early death amongst other non-communicable diseases characterized by irreversible limitations of airflow. Current reliable classification relies on forced expiratory volume in the first second (FEV1) and forced vital capacity (FVC) measured on spirometry. In order to provide more effective and individualized management, new markers are needed. Accumulating studies has shown the role of miRNA in the pathogenesis of COPD and the progression of the disease. Aim: This review aims to provide overview of the diagnostic capabilities of miRNA and identify gaps of knowledge for further studies. Method: A review based on Preferred Reporting Items for Systematic Reviews and Meta Analyses (PRISMA) was conducted with the database from Pubmed, Science Direct, and Proquest. Outcome: A total of nine studies has reported diagnostic accuracies of miRNA in distinguishing COPD and normal, COPD and AECOPD, and other subtypes of COPD Conclusion: Retrospective diagnostic analyses of miRNAs have shown several promising AUC and need to be followed up with reliable prospective designs. Further diagnostics studies, in particular those with clinical values, need to be conducted.","PeriodicalId":9324,"journal":{"name":"Biomolecular and Health Science Journal","volume":"61 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88796148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-30DOI: 10.20473/bhsj.v4i1.26914
Rizki Adrian Hakim, Stepanus Massora, Delfitri Lutfi, Hermina Novida
Graves’ Disease (GD) is the most common etiology of thyrotoxicosis, followed by toxic multinodular goiter and toxic adenoma. GD can be managed with anti-thyroid drugs (ATDs), surgery, or radioactive iodine (RAI). Thyroid-associated orbitopathy (TAO) or Graves’ Ophthalmopathy (GO) affects 25%-50% patients with GD, and its presence usually dissuade clinicians to use RAI in treating hyperthyroidism. The presence of GO is a relative contraindication use of RAI in patients with GD, as RAI can worsen existing GO. Corticosteroid prophylaxis can be given to such patients to reduce likelihood of worsening of GO. However, patient with moderate to severe active GO is currently advised against undergoing RAI. Established guidelines recommend the use of corticosteroid prophylaxis in these patients. We reported a patients with GD and orbitopathy who was treated with RAI and was given steroid prophylaxis to prevent worsening of GO.
{"title":"A Patient With Graves’ Disease And Thyroid-Associated Orbitopathy Undergoing Radioactive Iodine in Dr. Soetomo General Academic Hospital, Surabaya","authors":"Rizki Adrian Hakim, Stepanus Massora, Delfitri Lutfi, Hermina Novida","doi":"10.20473/bhsj.v4i1.26914","DOIUrl":"https://doi.org/10.20473/bhsj.v4i1.26914","url":null,"abstract":"Graves’ Disease (GD) is the most common etiology of thyrotoxicosis, followed by toxic multinodular goiter and toxic adenoma. GD can be managed with anti-thyroid drugs (ATDs), surgery, or radioactive iodine (RAI). Thyroid-associated orbitopathy (TAO) or Graves’ Ophthalmopathy (GO) affects 25%-50% patients with GD, and its presence usually dissuade clinicians to use RAI in treating hyperthyroidism. The presence of GO is a relative contraindication use of RAI in patients with GD, as RAI can worsen existing GO. Corticosteroid prophylaxis can be given to such patients to reduce likelihood of worsening of GO. However, patient with moderate to severe active GO is currently advised against undergoing RAI. Established guidelines recommend the use of corticosteroid prophylaxis in these patients. We reported a patients with GD and orbitopathy who was treated with RAI and was given steroid prophylaxis to prevent worsening of GO.","PeriodicalId":9324,"journal":{"name":"Biomolecular and Health Science Journal","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88827670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-30DOI: 10.20473/bhsj.v4i1.26250
Gondo Mastutik, A. Rahniayu, Dwi Murtiastutik, A. Arista, T. Setyaningrum, N. Missaoui, S. Putra
Introduction: Condyloma acuminata that is also known as genital warts are one of the most common sexually transmitted that caused by infection of Human papillomavirus (HPV). Persistent infection of Low Risk (LR) or High risk (HR) HPV is a risk factor for progress into benign or malignant cancer. The objective is to analyze distribution of genotype LR-HPV and HR-HPV at condyloma acuminata in anogenital region. Methods: A cross sectional study using were 36 lesions from men and women of condyloma acuminata patients. All subject signed the informed consent and ethic obtained from our institution, number 382/Panke.KKE/V/2016. The specimen was used to histopathological examination and to identified 40 genotypes of HPV using a reverse line blot assay.Results: The All patients were diagnosed as condyloma acuminata, some with focus dysplasia and koilocytosis. All patients were positive for HPV, including LR-HPV were HPV 6, 11, 42, 54, 61, 81,87,89 and HR-HPV were HPV 18, 26, 45, 51, 52, 66, 67, 68B, 69, 82. The single infection of LR-HPV was 44.4%, multiple infection LR/LR-HPV was 13,9% and the multiple infection of LR/HR-HPV was 41.7%. The LR-HPV infected 70,6% and HR-HPV infected 29,4%. Conclusion: LR-HPV is the major infection of condyloma acuminata, in single infection or multiple infection with HR-HPV. The most common infections were HPV 11, followed by HPV 6, HPV 18, HPV 51, and HPV 82. The determination of genotype of HPV can be used to predict the malignant transformation.
{"title":"Distribution Genotype High Risk (HR) And Low Risk (LR) Human Papillomavirus (HPV) at Condyloma Acuminata","authors":"Gondo Mastutik, A. Rahniayu, Dwi Murtiastutik, A. Arista, T. Setyaningrum, N. Missaoui, S. Putra","doi":"10.20473/bhsj.v4i1.26250","DOIUrl":"https://doi.org/10.20473/bhsj.v4i1.26250","url":null,"abstract":"Introduction: Condyloma acuminata that is also known as genital warts are one of the most common sexually transmitted that caused by infection of Human papillomavirus (HPV). Persistent infection of Low Risk (LR) or High risk (HR) HPV is a risk factor for progress into benign or malignant cancer. The objective is to analyze distribution of genotype LR-HPV and HR-HPV at condyloma acuminata in anogenital region. Methods: A cross sectional study using were 36 lesions from men and women of condyloma acuminata patients. All subject signed the informed consent and ethic obtained from our institution, number 382/Panke.KKE/V/2016. The specimen was used to histopathological examination and to identified 40 genotypes of HPV using a reverse line blot assay.Results: The All patients were diagnosed as condyloma acuminata, some with focus dysplasia and koilocytosis. All patients were positive for HPV, including LR-HPV were HPV 6, 11, 42, 54, 61, 81,87,89 and HR-HPV were HPV 18, 26, 45, 51, 52, 66, 67, 68B, 69, 82. The single infection of LR-HPV was 44.4%, multiple infection LR/LR-HPV was 13,9% and the multiple infection of LR/HR-HPV was 41.7%. The LR-HPV infected 70,6% and HR-HPV infected 29,4%. Conclusion: LR-HPV is the major infection of condyloma acuminata, in single infection or multiple infection with HR-HPV. The most common infections were HPV 11, followed by HPV 6, HPV 18, HPV 51, and HPV 82. The determination of genotype of HPV can be used to predict the malignant transformation.","PeriodicalId":9324,"journal":{"name":"Biomolecular and Health Science Journal","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85211593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-30DOI: 10.20473/bhsj.v4i1.26723
B. Ariobimo, M. D. Wibowo, A. Abdurachman
Introduction: Maxillofacial fractures can be caused by blunt trauma or sharp trauma. The purpose of this study was to identify the characteristics in patients with maxillofacial fractures who were treated in the Head and Neck Surgery Division of Dr. Soetomo General Academic Hospital, Surabaya during 2016.Methods: The research design was cross-sectional from patients with maxillofacial fractures. Those variables were evaluated are gender, age, type of etiology, site of maxillofacial fracture, gender and type of etiology based incidence, age and type of etiology based incidence. Data presented descriptively.Results: From 68 patients, consisted of 57 (83.82%) male, average age of 30.1 years old. The most common type of etiology was traffic accidents (92.64%), most common site of fractures were mandibular (33.33%), gender associated with the type of etiology was men who experienced traffic accidents (79.41%), and the age associated with the most types of events was ages 26-45 years with traffic accidents (47.05%).Conclusion: Maxillofacial fractures still become the problem that mainly cause is traffic accidents which occurred mostly in male and mandibular fracture as the most common site of fracture.
{"title":"Profile of Maxillofacial Fracture Patients at General Hospital in Surabaya","authors":"B. Ariobimo, M. D. Wibowo, A. Abdurachman","doi":"10.20473/bhsj.v4i1.26723","DOIUrl":"https://doi.org/10.20473/bhsj.v4i1.26723","url":null,"abstract":"Introduction: Maxillofacial fractures can be caused by blunt trauma or sharp trauma. The purpose of this study was to identify the characteristics in patients with maxillofacial fractures who were treated in the Head and Neck Surgery Division of Dr. Soetomo General Academic Hospital, Surabaya during 2016.Methods: The research design was cross-sectional from patients with maxillofacial fractures. Those variables were evaluated are gender, age, type of etiology, site of maxillofacial fracture, gender and type of etiology based incidence, age and type of etiology based incidence. Data presented descriptively.Results: From 68 patients, consisted of 57 (83.82%) male, average age of 30.1 years old. The most common type of etiology was traffic accidents (92.64%), most common site of fractures were mandibular (33.33%), gender associated with the type of etiology was men who experienced traffic accidents (79.41%), and the age associated with the most types of events was ages 26-45 years with traffic accidents (47.05%).Conclusion: Maxillofacial fractures still become the problem that mainly cause is traffic accidents which occurred mostly in male and mandibular fracture as the most common site of fracture.","PeriodicalId":9324,"journal":{"name":"Biomolecular and Health Science Journal","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90050055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-30DOI: 10.20473/bhsj.v4i1.26910
Astri Dewayani, Euvanggelia Dwilda Ferdinandus, R. P. Prastio, Indah Fahmiyah, A. Sofiah, Rodik Wahyu Indrawan, Mochammad Nurul, G. Aji, N. Gofur, Siti Khaerunnisa, Dewi Sriani, Yankel Sena
Introduction: Since the outbreak of Corona Disease-19 (COVID-19) spreads all over the world, various ways of health attempts have been conducted. However, overflowed information intertwines with mis/disinformation could raise public anxiety and stigma-related diseases. We aimed to assess the help of the young generation of millennials and Gen-Z whom are active college students in debunking hoaxes and myths of COVID-19 into their community.Method: The selected students were given a short course on COVID-19 basic information, prevention, and circulated myths. Later, they become ambassadors and actively educated via offline and online platforms. The impact of outspread information on audiences was investigated through a qualitative survey.Result: The knowledge of students were measured by pre- and post-test within the short course. Prior knowledge showed the least understanding part was prevention and myth of COVID-19. There was a significant improvement of knowledge in post-test after receiving seminar (p=0.0002). There were 97 respondents who filled the online survey that predominantly in young adulthood age. Respondent's insight was enhanced and they likely intend to spread the actual information to their surroundings.Conclusion: Appointing student as the spokesperson for health education can raise their social responsibility. Clarifying misinformation and health behaviour could be more influential within the same sharing community. In addition, the use of various online platforms could efficiently reach massive target, especially young ages.
{"title":"Maximizing Millennial Students Role in Combating COVID-19 Hoaxes and Myths","authors":"Astri Dewayani, Euvanggelia Dwilda Ferdinandus, R. P. Prastio, Indah Fahmiyah, A. Sofiah, Rodik Wahyu Indrawan, Mochammad Nurul, G. Aji, N. Gofur, Siti Khaerunnisa, Dewi Sriani, Yankel Sena","doi":"10.20473/bhsj.v4i1.26910","DOIUrl":"https://doi.org/10.20473/bhsj.v4i1.26910","url":null,"abstract":"Introduction: Since the outbreak of Corona Disease-19 (COVID-19) spreads all over the world, various ways of health attempts have been conducted. However, overflowed information intertwines with mis/disinformation could raise public anxiety and stigma-related diseases. We aimed to assess the help of the young generation of millennials and Gen-Z whom are active college students in debunking hoaxes and myths of COVID-19 into their community.Method: The selected students were given a short course on COVID-19 basic information, prevention, and circulated myths. Later, they become ambassadors and actively educated via offline and online platforms. The impact of outspread information on audiences was investigated through a qualitative survey.Result: The knowledge of students were measured by pre- and post-test within the short course. Prior knowledge showed the least understanding part was prevention and myth of COVID-19. There was a significant improvement of knowledge in post-test after receiving seminar (p=0.0002). There were 97 respondents who filled the online survey that predominantly in young adulthood age. Respondent's insight was enhanced and they likely intend to spread the actual information to their surroundings.Conclusion: Appointing student as the spokesperson for health education can raise their social responsibility. Clarifying misinformation and health behaviour could be more influential within the same sharing community. In addition, the use of various online platforms could efficiently reach massive target, especially young ages.","PeriodicalId":9324,"journal":{"name":"Biomolecular and Health Science Journal","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83232768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-30DOI: 10.20473/bhsj.v4i1.27427
Agung Sosiawan, D. Wahjuningrum, A. Bhardwaj, Kratika Mishra, Sheetal Khandelwal, Amit Bhardwaj, Shivani Bhardwaj
In December 2019, an outbreak in the city of Wuhan, Hubei China occurred and was named COVID- 19 by the World Health Organization and declared as a pandemic on January 30, 2020. The etiologic agent of acute respiratory disease is the novel corona virus 2019 (2019-nCoV) or the extreme acute respiratory syndrome corona virus 2 (SARS-CoV-2). During many dental operations, aerosols are produced and these aerosol methods, which are major problems for dentists, have become the main area of concern in dentistry. Dentists are at greatest risk since they are located close to the oropharynx. This study summarizes the effect of coronavirus disease 2019 (COVID-19) on dental care, administration, and emergency dental treatment service. It also identifies COVID-19 and explains about six commandments for dental practitioners during the treatment process to be practiced during the pandemic.
{"title":"Six Commandments of Treatment Protocols During Covid-19 Pandemic in Dentistry","authors":"Agung Sosiawan, D. Wahjuningrum, A. Bhardwaj, Kratika Mishra, Sheetal Khandelwal, Amit Bhardwaj, Shivani Bhardwaj","doi":"10.20473/bhsj.v4i1.27427","DOIUrl":"https://doi.org/10.20473/bhsj.v4i1.27427","url":null,"abstract":"In December 2019, an outbreak in the city of Wuhan, Hubei China occurred and was named COVID- 19 by the World Health Organization and declared as a pandemic on January 30, 2020. The etiologic agent of acute respiratory disease is the novel corona virus 2019 (2019-nCoV) or the extreme acute respiratory syndrome corona virus 2 (SARS-CoV-2). During many dental operations, aerosols are produced and these aerosol methods, which are major problems for dentists, have become the main area of concern in dentistry. Dentists are at greatest risk since they are located close to the oropharynx. This study summarizes the effect of coronavirus disease 2019 (COVID-19) on dental care, administration, and emergency dental treatment service. It also identifies COVID-19 and explains about six commandments for dental practitioners during the treatment process to be practiced during the pandemic.","PeriodicalId":9324,"journal":{"name":"Biomolecular and Health Science Journal","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82462979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-30DOI: 10.20473/bhsj.v4i1.25392
Ida Fitriawati, M. Wahyunitisari, R. Prasetyo, Dwiyanti Puspitasari
Introduction: Urinary tract infection (UTI) by extended-spectrum beta-lactamase-producing bacteria often results in a delay in obtaining appropriate antibiotics. The information on patients’ clinical characteristics is necessary for early recognition and the selection of empiric antibiotic therapy. This study aims to investigate the clinical characteristics and the length of therapy of patients with urinary tract infections by those resistant bacteria.Method: This study utilizes a cross-sectional design. Medical records of hospitalized children aged 1-18 months with UTI due to ESBL-producing bacteria at Dr. Soetomo general hospital between January 1, 2017 - July 20, 2020, were reviewed retrospectively. Variables of interest were the demographic data, underlying diseases, causative organism, clinical presentation, maximal body temperature, and length of antibiotic therapy.Results: Among 37 patients enrolled, 25 patients were female. The incidence of urinary tract infection in children was dominated by age 1-12 months old (37.8%). Urological abnormalities were presented in 62.2% of patients. ESBL-producing Escherichia coli was the most common isolated uropathogen (62.2%). High fever was found in 10/28 patients (35.7%). In 17 patients (45.9%), the total duration of antibiotic therapy was 8-14 days.Conclusion: In children with UTI, especially in the infant group, who had urological abnormality or present with a high fever, and who do not respond to empiric therapy should be suspected of developing UTI due to ESBL-producing bacteria.
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